Annamaria Colao

Summary

Affiliation: Federico II University
Country: Italy

Publications

  1. ncbi Prevalence of the metabolic syndrome in moderately-severely obese subjects with and without growth hormone deficiency
    C Di Somma
    IRCCS SDN Foundation, Naples, Italy
    J Endocrinol Invest 33:171-7. 2010
  2. ncbi Results of a single-center observational 10-year survey study on recurrence of hyperprolactinemia after pregnancy and lactation
    Renata S Auriemma
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Via S Pansini 5, I 80131 Napoli, Italy
    J Clin Endocrinol Metab 98:372-9. 2013
  3. ncbi Serum 25-Hydroxyvitamin D Levels, phosphoprotein enriched in diabetes gene product (PED/PEA-15) and leptin-to-adiponectin ratio in women with PCOS
    Silvia Savastano
    Department of Molecular and Clinical Endocrinology and Oncology, Division of Endocrinology, University Federico II of Naples, Via S, Pansini 5, Naples, 80131, Italy
    Nutr Metab (Lond) 8:84. 2011
  4. ncbi The endocrine tumor summit 2008: appraising therapeutic approaches for acromegaly and carcinoid syndrome
    Anne Klibanski
    Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Pituitary 13:266-86. 2010
  5. ncbi Relationship between heart rate recovery and inflammatory markers in patients with polycystic ovary syndrome: a cross-sectional study
    Francesco Giallauria
    Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Cardiac Rehabilitation Unit, University of Naples Federico II, Naples, Italy
    J Ovarian Res 2:3. 2009
  6. ncbi Prolactinomas, Cushing's disease and acromegaly: debating the role of medical therapy for secretory pituitary adenomas
    Beverly Mk Biller
    Neuroendocrine Clinical Center, Massachusetts General Hospital, Boston, USA
    BMC Endocr Disord 10:10. 2010
  7. ncbi Prolactin and prostate hypertrophy: a pilot observational, prospective, case-control study in men with prolactinoma
    Annamaria Colao
    Department of Clinical and Molecular Endocrinology and Oncology, University Federico II of Naples, 80131 Naples, Italy
    J Clin Endocrinol Metab 89:2770-5. 2004
  8. ncbi Effect of gender and gonadal status on the long-term response to somatostatin analogue treatment in acromegaly
    Annamaria Colao
    Departments of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Naples, Italy
    Clin Endocrinol (Oxf) 63:342-9. 2005
  9. ncbi Partial surgical removal of growth hormone-secreting pituitary tumors enhances the response to somatostatin analogs in acromegaly
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 91:85-92. 2006
  10. ncbi The acromegalic arthropathy
    A Colao
    Section of Endocrinology, Department of Molecular and Clinical Endocrinology, Federico II, University of Naples, Naples, Italy
    J Endocrinol Invest 28:24-31. 2005

Detail Information

Publications172 found, 100 shown here

  1. ncbi Prevalence of the metabolic syndrome in moderately-severely obese subjects with and without growth hormone deficiency
    C Di Somma
    IRCCS SDN Foundation, Naples, Italy
    J Endocrinol Invest 33:171-7. 2010
    ....
  2. ncbi Results of a single-center observational 10-year survey study on recurrence of hyperprolactinemia after pregnancy and lactation
    Renata S Auriemma
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Via S Pansini 5, I 80131 Napoli, Italy
    J Clin Endocrinol Metab 98:372-9. 2013
    ..The current survey study investigated the recurrence rate of hyperprolactinemia after cabergoline (CAB)-induced pregnancy and after lactation as well as safety of CAB exposure during early gestation...
  3. ncbi Serum 25-Hydroxyvitamin D Levels, phosphoprotein enriched in diabetes gene product (PED/PEA-15) and leptin-to-adiponectin ratio in women with PCOS
    Silvia Savastano
    Department of Molecular and Clinical Endocrinology and Oncology, Division of Endocrinology, University Federico II of Naples, Via S, Pansini 5, Naples, 80131, Italy
    Nutr Metab (Lond) 8:84. 2011
    ..abstract:..
  4. ncbi The endocrine tumor summit 2008: appraising therapeutic approaches for acromegaly and carcinoid syndrome
    Anne Klibanski
    Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Pituitary 13:266-86. 2010
    ..Panel opinions, based on the level of available scientific evidence, were polled. Finally, their views were compared with those of surveyed community-based endocrinologists and neurosurgeons...
  5. ncbi Relationship between heart rate recovery and inflammatory markers in patients with polycystic ovary syndrome: a cross-sectional study
    Francesco Giallauria
    Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Cardiac Rehabilitation Unit, University of Naples Federico II, Naples, Italy
    J Ovarian Res 2:3. 2009
    ..A subclinical increase of the inflammation markers has been also observed in the PCOS. This study was designed to study the relationships between HRR and inflammatory markers in PCOS women...
  6. ncbi Prolactinomas, Cushing's disease and acromegaly: debating the role of medical therapy for secretory pituitary adenomas
    Beverly Mk Biller
    Neuroendocrine Clinical Center, Massachusetts General Hospital, Boston, USA
    BMC Endocr Disord 10:10. 2010
    ....
  7. ncbi Prolactin and prostate hypertrophy: a pilot observational, prospective, case-control study in men with prolactinoma
    Annamaria Colao
    Department of Clinical and Molecular Endocrinology and Oncology, University Federico II of Naples, 80131 Naples, Italy
    J Clin Endocrinol Metab 89:2770-5. 2004
    ..In conclusion, in young men with prolactinoma PRL excess is unlikely to have effects on the prostate per se, because it is accompanied by low testosterone and DHT levels that produce the major effects...
  8. ncbi Effect of gender and gonadal status on the long-term response to somatostatin analogue treatment in acromegaly
    Annamaria Colao
    Departments of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Naples, Italy
    Clin Endocrinol (Oxf) 63:342-9. 2005
    ..GH and IGF-I secretion is related to gender and age...
  9. ncbi Partial surgical removal of growth hormone-secreting pituitary tumors enhances the response to somatostatin analogs in acromegaly
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 91:85-92. 2006
    ..Surgery is a cornerstone in the treatment of acromegaly, but its efficacy in large, invasive tumors is scant...
  10. ncbi The acromegalic arthropathy
    A Colao
    Section of Endocrinology, Department of Molecular and Clinical Endocrinology, Federico II, University of Naples, Naples, Italy
    J Endocrinol Invest 28:24-31. 2005
    ..Arthropathy can be reversed by normalizing GH and IGF-I levels only at the initial stage. If the disease is left untreated for long time, the osteo-articular sequelae cannot be modified by any treatment of acromegaly...
  11. ncbi Efficacy of 12-month treatment with the GH receptor antagonist pegvisomant in patients with acromegaly resistant to long-term, high-dose somatostatin analog treatment: effect on IGF-I levels, tumor mass, hypertension and glucose tolerance
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Section of Endocrinology, Federico II University of Naples, Italy
    Eur J Endocrinol 154:467-77. 2006
    ..We aimed to investigate the efficacy of pegvisomant in patients with acromegaly resistant to long-term (> or = 24-month), high-dose treatment with octreotide-LAR (40 mg/month) or lanreotide (120 mg/month)...
  12. ncbi The natural history of partial growth hormone deficiency in adults: a prospective study on the cardiovascular risk and atherosclerosis
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Via S Pansini 5, 80131 Napoli, Italy
    J Clin Endocrinol Metab 91:2191-200. 2006
    ..Partial GH deficiency (GHD) in adults is poorly studied...
  13. ncbi Somatostatin analogs in treatment of non-growth hormone-secreting pituitary adenomas
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
    Endocrine 20:279-83. 2003
    ..No evident effect of tumor shrinkage has been reported. At present, the use of somatostatin analogs in clinically nonfunctioning adenomas is questioned...
  14. ncbi New perspectives in the medical treatment of acromegaly
    A Colao
    Section of Endocrinology, Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy
    J Endocrinol Invest 28:58-66. 2005
    ..These drugs have been also shown to possess strong GH-inhibitory activity in primary cultures from GH-secreting adenomas. These drugs are the future perspectives in the treatment of patients with GH-secreting or GH/PRL-secreting tumors...
  15. ncbi Beginning to end: cardiovascular implications of growth hormone (GH) deficiency and GH therapy
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, University Federico II of Naples, Via S Pansini 5, 80123 Naples, Italy
    Growth Horm IGF Res 16:S41-8. 2006
    ..This review discusses the roles of GHD and GH replacement therapy in the development of cardiovascular disease...
  16. ncbi Circulating insulin-like growth factor-I levels are correlated with the atherosclerotic profile in healthy subjects independently of age
    A Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
    J Endocrinol Invest 28:440-8. 2005
    ..Our results support a role of the IGF/IGFBP-3 axis in the pathogenesis of atherosclerosis...
  17. ncbi Does a gender-related effect of growth hormone (GH) replacement exist on cardiovascular risk factors, cardiac morphology, and performance and atherosclerosis? Results of a two-year open, prospective study in young adult men and women with severe GH defici
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 90:5146-55. 2005
    ..GH secretion and response to GH replacement are gender-related...
  18. ncbi Influence of growth hormone on cardiovascular health and disease
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
    Treat Endocrinol 2:347-56. 2003
    ..Although these data need to be confirmed in more extensive studies, such promising results open new perspectives for somatropin therapy. The role of GH secretagogues in heart failure is still unknown...
  19. ncbi The treatment algorithm of acromegaly
    A Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Section of Endocrinology, Federico II University, Naples, Italy
    J Endocrinol Invest 26:39-45. 2003
  20. ncbi Hypothalamic-pituitary-gonadal axis function after successful kidney transplantation in men and women
    Libuse Tauchmanova
    Department of Molecular and Clinical Endocrinology and Oncology, University Federico II of Naples, Cantazaro, Italy
    Hum Reprod 19:867-73. 2004
    ..Renal transplantation (RT) is the most common solid organ transplant procedure. Several studies have reported on gonadal function in male and female RT recipients with controversial results...
  21. ncbi The heart: an end-organ of GH action
    A Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Via S Pansini 5, 80131 Naples, Italy
    Eur J Endocrinol 151:S93-101. 2004
    ..These beneficial effects appear earlier in young patients with short disease duration than in elderly patients. In conclusion, GH and IGF-I play a main role in the regulation of cardiac development and performance...
  22. ncbi Insulin-like growth factor-1 deficiency determines increased intima-media thickness at common carotid arteries in adult patients with growth hormone deficiency
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy
    Clin Endocrinol (Oxf) 61:360-6. 2004
    ..To investigate the role of IGF-1 on intima-media thickness (IMT) at common carotid arteries by Doppler ultrasonography...
  23. ncbi The severity of growth hormone deficiency correlates with the severity of cardiac impairment in 100 adult patients with hypopituitarism: an observational, case-control study
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, 80131 Napoli, Italy
    J Clin Endocrinol Metab 89:5998-6004. 2004
    ..5% of non-GHD, and 90% of controls. In conclusion, cardiac performance is correlated with the GH status because significant impairment was found in patients with severe and partial GHD but not in non-GHD hypopituitary patients...
  24. ncbi Growth hormone/insulin-like growth factor-I system and connective tissues: basic aspects and clinical implications
    Annamaria Colao
    Unit of Neuroendocrinology, Department of Molecular and Clinical Endocrinology and Oncology, University Federico II of Naples, Via S Pancini C, Naples 80131, Italy
    Rheum Dis Clin North Am 31:29-42, viii. 2005
    ..This article reviews basic and clinical aspects of the effects of growth hormone and insulin-like growth factor-I on the connective tissues...
  25. ncbi Short-term effects of growth hormone (GH) treatment or deprivation on cardiovascular risk parameters and intima-media thickness at carotid arteries in patients with severe GH deficiency
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 90:2056-62. 2005
    ..These findings support the indication for GH replacement in severe GH deficiency adult patients...
  26. ncbi Systemic complications of acromegaly: epidemiology, pathogenesis, and management
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, 80131 Naples, Italy
    Endocr Rev 25:102-52. 2004
    ..Finally, the most important cause of morbidity and functional disability of the disease is arthropathy, which can be reversed at an initial stage, but not if the disease is left untreated for several years...
  27. ncbi Drug insight: Cabergoline and bromocriptine in the treatment of hyperprolactinemia in men and women
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, University Federico II, Naples, Italy
    Nat Clin Pract Endocrinol Metab 2:200-10. 2006
    ..Fewer results are available for men than for women, but there is no evidence that men are less responsive to dopamine agonists than are women...
  28. ncbi The role of somatostatin and dopamine receptors as molecular targets for the treatment of patients with pituitary adenomas
    A Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
    Eur J Endocrinol 156:S1. 2007
  29. ncbi Combined therapy of somatostatin analogues and dopamine agonists in the treatment of pituitary tumours
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Via S Pansini 5, 80131 Naples, Italy
    Eur J Endocrinol 156:S57-63. 2007
    ..No data are available in other pituitary tumour histotypes. Preliminary observations in patients with clinically non-functioning adenomas are very promising...
  30. ncbi GH and IGF-I excess control contributes to blood pressure control: results of an observational, retrospective, multicentre study in 105 hypertensive acromegalic patients on hypertensive treatment
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Naples, Italy
    Clin Endocrinol (Oxf) 69:613-20. 2008
    ..Approximately one-third of patients with acromegaly have concomitant hypertension. The outcome of hypertension after treatment of acromegaly is unknown...
  31. ncbi Effects of initial therapy for five years with somatostatin analogs for acromegaly on growth hormone and insulin-like growth factor-I levels, tumor shrinkage, and cardiovascular disease: a prospective study
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, 80131 Naples, Italy
    J Clin Endocrinol Metab 94:3746-56. 2009
    ..The objective of the study was to evaluate the efficacy of 5 yr of depot somatostatin analogs (SSAs) as first-line therapy in acromegaly...
  32. ncbi A reappraisal of diagnosing GH deficiency in adults: role of gender, age, waist circumference, and body mass index
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology, Section of Endocrinology, University of Naples Federico II, Italy, 80131 Naples, Italy
    J Clin Endocrinol Metab 94:4414-22. 2009
    ..The objective of the study was to reevaluate the diagnostic accuracy of GH peak after GHRH plus arginine test (GHRH+ARG) according to patients' age, body mass index (BMI), and waist circumference to diagnose GH deficiency (GHD)...
  33. ncbi Prolactinomas in children and adolescents
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
    Endocr Dev 17:146-59. 2010
    ..Radiotherapy should be limited to the cases with aggressive tumors, nonresponsive to dopamine agonists, because of the risk of neurological damage and hypopituitarism later in the lives of these patients...
  34. ncbi 5 Long-term acromegaly and associated cardiovascular complications: a case-based review
    Annamaria Colao
    Universita degli Studi di Napoli Federico II, Department of Molecular and Clinical Endocrinology and Oncology, Via S Pansini 5, 80131 Napoli, Italy
    Best Pract Res Clin Endocrinol Metab 23:S31-8. 2009
    ..The roles of surgery and medical treatment are discussed in the context of using optimal treatment strategies to help reverse cardiac hypertrophy and normalize other cardiac risk factors...
  35. ncbi Somatostatin analogues: treatment of pituitary and neuroendocrine tumors
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Naples, Italy
    Prog Brain Res 182:281-94. 2010
    ..A recent study has also demonstrated a beneficial effect of OCT long-acting release in patients with non-functioning NETs independently from their progression status. These data open the treatment with SSAs in all NET patients...
  36. ncbi Pituitary carcinomas
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology, Federico II University of Naples, Naples, Italy
    Front Horm Res 38:94-108. 2010
    ....
  37. ncbi Growth hormone nadir during oral glucose load depends on waist circumference, gender and age: normative data in 231 healthy subjects
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Section of Endocrinology, University Federico II of Naples, Naples, Italy
    Clin Endocrinol (Oxf) 74:234-40. 2011
    ..Design  Analytical, retrospective...
  38. ncbi Glucose tolerance and somatostatin analog treatment in acromegaly: a 12-month study
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Via S Pansini 5, Naples, Italy
    J Clin Endocrinol Metab 94:2907-14. 2009
    ..The objective of the study was to investigate the impact of first-line somatostatin analogs (SSAs) on glucose tolerance (GT) in acromegaly...
  39. ncbi Octreotide LAR vs. surgery in newly diagnosed patients with acromegaly: a randomized, open-label, multicentre study
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Section of Endocrinology, Federico II University of Naples, Naples, Italy
    Clin Endocrinol (Oxf) 70:757-68. 2009
    ..This prospective randomized study evaluated the efficacy and safety of octreotide LAR vs. surgery in newly diagnosed acromegalic patients...
  40. ncbi Significant tumour shrinkage after 12 months of lanreotide Autogel-120 mg treatment given first-line in acromegaly
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology, University Federico II of Naples, Naples, Italy
    Clin Endocrinol (Oxf) 71:237-45. 2009
    ..To evaluate GH and IGF-I control and tumour shrinkage in newly diagnosed patients with acromegaly treated first-line with lanreotide-Autogel (ATG) 120 mg. Design Open, prospective...
  41. ncbi Pregnancy outcomes following cabergoline treatment: extended results from a 12-year observational study
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Section of Endocrinology, University Federico II of Naples, Naples, Italy
    Clin Endocrinol (Oxf) 68:66-71. 2008
    ..Although cabergoline has been used to treat hyperprolactinaemia since the mid-1990s, safety data related to maternal and foetal exposure to this agent are still limited...
  42. ncbi No greater incidence or worsening of cardiac valve regurgitation with somatostatin analog treatment of acromegaly
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Via S Pansini 5, Naples, Italy
    J Clin Endocrinol Metab 93:2243-8. 2008
    ..Excess GH and IGF-I in acromegaly are associated with reduced life expectancy due to cardiovascular complications...
  43. ncbi Impact of treating acromegaly first with surgery or somatostatin analogs on cardiomyopathy
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Via S Pansini 5, Naples, Italy
    J Clin Endocrinol Metab 93:2639-46. 2008
    ..The objective of the study was to investigate whether first-line surgery or somatostatin analogs (SSA) have a different outcome on cardiomyopathy after 12 months...
  44. ncbi Growth hormone-secreting tumor shrinkage after 3 months of octreotide-long-acting release therapy predicts the response at 12 months
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 93:3436-42. 2008
    ..The objective of the study was to evaluate whether tumor shrinkage or GH and IGF-I levels achieved after 3 months predicted tumor shrinkage after 12 months of octreotide-long-acting release (LAR) treatment...
  45. ncbi Growth hormone treatment on atherosclerosis: results of a 5-year open, prospective, controlled study in male patients with severe growth hormone deficiency
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 93:3416-24. 2008
    ..Severe GH deficiency (GHD) is associated with, increased cardiovascular risk and intima-media thickness (IMT) at major arteries...
  46. ncbi Increased prevalence of tricuspid regurgitation in patients with prolactinomas chronically treated with cabergoline
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Via S Pansini 5, 80131 Napoli, Italy
    J Clin Endocrinol Metab 93:3777-84. 2008
    ..Cabergoline, a dopamine receptor-2 agonist used to treat prolactinomas, was associated with increased risk of cardiac valve disease in Parkinson's disease...
  47. ncbi Medical therapy of pituitary adenomas: effects on tumor shrinkage
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Naples, Italy
    Rev Endocr Metab Disord 10:111-23. 2009
    ..NFA respond very scantly to both DA and SSA even if receptors targeting these drugs are present. Whether this is due to limited receptor number or alterations of post-receptor pathway is still unknown...
  48. ncbi Impact of somatostatin analogs versus surgery on glucose metabolism in acromegaly: results of a 5-year observational, open, prospective study
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Section of Endocrinology, University Federico II of Naples, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 94:528-37. 2009
    ..The aim of the study was to investigate the 5-yr impact of surgery and somatostatin analogs (SSA) on glucose metabolism in acromegaly...
  49. ncbi Determinants of cardiac disease in newly diagnosed patients with acromegaly: results of a 10 year survey study
    Annamaria Colao
    Section of Endocrinology, Department of Molecular and Clinical Endocrinology and Oncology, University Federico II of Naples, Via S Pansini 5, 80131 Naples, Italy
    Eur J Endocrinol 165:713-21. 2011
    ..The most frequent cause of death in acromegaly is cardiomyopathy...
  50. ncbi Gender- and age-related differences in the endocrine parameters of acromegaly
    A Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy
    J Endocrinol Invest 25:532-8. 2002
    ..Women have lower IGF-I levels but higher GH nadir after glucose load than men. These age and gender differences should be considered to appropriately evaluate the activity of acromegaly throughout a life-span...
  51. ncbi The growth hormone (GH) response to the arginine plus GH-releasing hormone test is correlated to the severity of lipid profile abnormalities in adult patients with GH deficiency
    A Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy
    J Clin Endocrinol Metab 84:1277-82. 1999
    ....
  52. ncbi Dopamine receptor agonists for treating prolactinomas
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Via S Pansini 5, 80131 Naples, Italy
    Expert Opin Investig Drugs 11:787-800. 2002
    ..The great efficacy of this compound together with its excellent tolerability makes this drug the current treatment of choice for the majority of patients with hyperprolactinaemic disorders...
  53. ncbi Bone loss is correlated to the severity of growth hormone deficiency in adult patients with hypopituitarism
    A Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy
    J Clin Endocrinol Metab 84:1919-24. 1999
    ..These abnormalities were consistently present in all patients with GHD regardless of the presence of additional hormone deficits, suggesting that GHD plays a central role in the development of osteopenia in hypopituitary patients...
  54. ncbi The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: a 12-month prospective study
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, 80131 Naples, Italy
    J Clin Endocrinol Metab 87:1088-93. 2002
    ..A similar period of GH deprivation induced a further impairment of lipid profile and cardiac performance. This finding strongly supports the need of GH replacement in adult GHD patients...
  55. ncbi Cardiovascular effects of depot long-acting somatostatin analog Sandostatin LAR in acromegaly
    A Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy
    J Clin Endocrinol Metab 85:3132-40. 2000
    ..The sustained suppression of IGF-I levels was followed by a significant reduction of LVMi in all patients already after 3 months of treatment, with recovery of LV hypertrophy in 6 of 11 patients. (ABSTRACT TRUN..
  56. ncbi Effect of a six-month treatment with lanreotide on cardiovascular risk factors and arterial intima-media thickness in patients with acromegaly
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Via Sergio Pansini 5, 80131, Naples, Italy
    Eur J Endocrinol 146:303-9. 2002
    ..4 +/- 12.6 mU/l, IGF--I=866.0 +/- 55.8 microg/l) and 24 healthy subjects sex-, age- and body mass index-matched with the patients (as controls)...
  57. ncbi Cabergoline
    A Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy
    Expert Opin Pharmacother 1:555-74. 2000
    ..CAB was also reported to have some efficacy in patients with Nelson's syndrome and Cushing's disease although these data are available only for limited case reports...
  58. ncbi Hormone levels and tumour size response to quinagolide and cabergoline in patients with prolactin-secreting and clinically non-functioning pituitary adenomas: predictive value of pituitary scintigraphy with 123I-methoxybenzamide
    A Colao
    Departments of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples Nuclear Medicine, National Cancer Institute, Fondazione G Pascale, Naples, Italy
    Clin Endocrinol (Oxf) 52:437-45. 2000
    ..Dopamine agonists are indicated as primary therapy for PRL-secreting pituitary adenomas, while controversial results have been reported in nonfunctioning adenomas (NFA)...
  59. ncbi Persistence of increased cardiovascular risk in patients with Cushing's disease after five years of successful cure
    A Colao
    Department of Molecular and Clinical Endocrinology, Federico II University, Naples, Italy
    J Clin Endocrinol Metab 84:2664-72. 1999
    ....
  60. ncbi Macroprolactinoma shrinkage during cabergoline treatment is greater in naive patients than in patients pretreated with other dopamine agonists: a prospective study in 110 patients
    A Colao
    Department of Molecular and Clinical Endocrinology, Federico II University of Naples, Italy
    J Clin Endocrinol Metab 85:2247-52. 2000
    ..In conclusion, the prevalence of macroprolactinoma shrinkage after CAB treatment at standard doses for 1-3 yr was higher in naive patients (92.3%) than in intolerant (42.1%), resistant (30.3%), and responsive patients (38.4%). Thus, C..
  61. ncbi Ultrasonographic evidence of joint thickening reversibility in acromegalic patients treated with lanreotide for 12 months
    A Colao
    Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy
    Clin Endocrinol (Oxf) 51:611-8. 1999
    ..A major cause of morbidity and functional disability in acromegaly is represented by axial and peripheral arthropathy...
  62. ncbi Impaired cardiac performance in elderly patients with growth hormone deficiency
    A Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy
    J Clin Endocrinol Metab 84:3950-5. 1999
    ..614; P < 0.05) and with systolic and diastolic blood pressures both at rest (r = 0.745; P < 0.01 and r = 0.650; P < 0.05) and at peak exercise (r = 0.684; P < 0.05 and r =..
  63. ncbi Effect of two years of growth hormone and insulin-like growth factor-I suppression on prostate diseases in acromegalic patients
    A Colao
    Department of Clinical and Molecular Endocrinology and Oncology, Federico II University of Naples, Italy
    J Clin Endocrinol Metab 85:3754-61. 2000
    ..These data suggest that hyperplasia, but not cancer, is frequent in acromegalic men, and that the GH-IGF axis and age are independently associated with the development of this process...
  64. ncbi Effect of growth hormone (GH) and/or testosterone replacement on the prostate in GH-deficient adult patients
    Annamaria Colao
    Department of Clinical and Molecular Endocrinology and Oncology, Federico II University of Naples, Italy
    J Clin Endocrinol Metab 88:88-94. 2003
    ..In these cases, GH replacement might be performed sequentially to reduce the hypertrophic effect of combining GH and testosterone...
  65. ncbi Increased arterial intima-media thickness by B-M mode echodoppler ultrasonography in acromegaly
    A Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Naples, Italy
    Clin Endocrinol (Oxf) 54:515-24. 2001
    ..Despite the increasing evidence for the existence of a specific cardiomyopathy in acromegaly, the presence of vascular abnormalities has been never investigated...
  66. ncbi Growth hormone and the heart
    A Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
    Clin Endocrinol (Oxf) 54:137-54. 2001
    ..Although these data need to be confirmed in more extensive studies, such promising results seem to open new perspectives for GH treatment in humans...
  67. ncbi Cardiovascular consequences of early-onset growth hormone excess
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 87:3097-104. 2002
    ..These deleterious effects of early-onset acromegaly are ameliorated by suppressing GH/IGF-I levels for 6 months...
  68. ncbi (99m)Technetium pentavalent dimercaptosuccinic acid scintigraphy in the follow-up of clinically nonfunctioning pituitary adenomas after radiotherapy
    Annamaria Colao
    Department of Clinical and Molecular Endocrinology and Oncology, University Federico II of Naples, Italy
    Clin Endocrinol (Oxf) 56:713-21. 2002
    ....
  69. ncbi In vivo and in vitro effects of octreotide, quinagolide and cabergoline in four hyperprolactinaemic acromegalics: correlation with somatostatin and dopamine D2 receptor scintigraphy
    D Ferone
    Department of Molecular and Clinical Endocrinology, Federico II, University of Naples, Italy
    Clin Endocrinol (Oxf) 54:469-77. 2001
    ..The new potent DA might be primarily considered in the medical treatment of hyperprolactinemic acromegalics, while SA alone or in combination with DA in case of ineffective hormone suppression...
  70. ncbi Visceral fat is associated with cardiovascular risk in women with polycystic ovary syndrome
    Teresa Cascella
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Naples 80131, Italy
    Hum Reprod 23:153-9. 2008
    ..The aim of this study was to evaluate the relationship between visceral fat (VF) and early markers of CVD in PCOS women...
  71. ncbi The treatment with cabergoline for 24 month normalizes the quality of seminal fluid in hyperprolactinaemic males
    Michele De Rosa
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy
    Clin Endocrinol (Oxf) 64:307-13. 2006
    ..3-53% of the patients. CONCLUSIONS: Twenty-four months of cabergoline treatment restored gonadal function in 66.7% of men with hyperprolactinaemia...
  72. ncbi GH release after GHRH plus arginine administration in obese and overweight women with polycystic ovary syndrome
    F Orio
    Department of Molecular and Clinical Endocrinology, University of Naples Federico II, Naples, Italy
    J Endocrinol Invest 26:117-22. 2003
    ..In conclusion, in PCOS women there is a BMI-independent alteration of the GH levels. Further investigations will be necessary to establish the real cause of these data...
  73. ncbi Left ventricular diastolic function and cardiac performance during exercise in patients with acromegaly
    Letizia Spinelli
    Department of Internal Medicine, Federico II University, 80131 Naples, Italy
    J Clin Endocrinol Metab 88:4105-9. 2003
    ..Combined analysis of pulmonary vein and mitral flow velocity curves allows the identification of impaired LV diastolic function in such patients...
  74. ncbi PRL secreting adenomas in male patients
    Antonio Ciccarelli
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Via S. Pansini 5, 80131, Naples, Italy
    Pituitary 8:39-42. 2005
    ....
  75. ncbi The growth hormone-insulin-like growth factor axis in glycogen storage disease type 1: evidence of different growth patterns and insulin-like growth factor levels in patients with glycogen storage disease type 1a and 1b
    Daniela Melis
    Department of Pediatrics, Federico II University, Naples, Italy
    J Pediatr 156:663-70.e1. 2010
    ..To investigate the growth hormone (GH)-insulin-like growth factor (IGF) system in patients with glycogen storage disease type 1 (GSD1)...
  76. ncbi Cardiopulmonary impairment in young women with polycystic ovary syndrome
    Francesco Orio
    Department of Molecular, Clinical Endocrinology, and Oncology, University Federico II of Naples, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 91:2967-71. 2006
    ..At the moment, no evaluation of cardiopulmonary functional capacity in young patients with PCOS has been performed...
  77. ncbi Resistance to cabergoline as compared with bromocriptine in hyperprolactinemia: prevalence, clinical definition, and therapeutic strategy
    A Di Sarno
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, 80131 Naples, Italy
    J Clin Endocrinol Metab 86:5256-61. 2001
    ..Therefore, an absence of tumor shrinkage cannot be considered as end point to indicate resistance to CAB, and increasing the dose of CAB higher than 3 mg/wk does not seem to be helpful in controlling PRL hypersecretion...
  78. ncbi Prevalence and determinants of left ventricular hypertrophy in acromegaly: impact of different methods of indexing left ventricular mass
    Giovanni Vitale
    Department of Molecular Endocrinology, Federico II School of Medicine, University of Naples, Italy
    Clin Endocrinol (Oxf) 60:343-9. 2004
    ..7. CONCLUSIONS: LVM indexed for height2.7 appears to be the most appropriate method to identify LVH in acromegaly, particularly in overweight patients and those with shorter disease duration...
  79. ncbi Bone demineralization and vertebral fractures in endogenous cortisol excess: role of disease etiology and gonadal status
    Libuse Tauchmanova
    Department of Molecular, Clinical Endocrinology, and Oncology, Federico II University of Naples, via Sergia Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 91:1779-84. 2006
    ..e. Cushing's disease and adrenal and ectopic Cushing's syndrome...
  80. ncbi Expression and function of somatostatin receptor subtype 1 in human growth hormone secreting pituitary tumors deriving from patients partially responsive or resistant to long-term treatment with somatostatin analogs
    C Matrone
    Division of Pharmacology, Department of Neuroscience, Federico II University, Naples, Italy
    Neuroendocrinology 79:142-8. 2004
    ....
  81. ncbi Bone density and turnover in young adult patients with growth hormone deficiency after 2-year growth hormone replacement according with gender
    F Rota
    Department of Molecular and Clinical Endocrinology, Federico II University of Naples, 80131 Naples, Italy
    J Endocrinol Invest 31:94-102. 2008
    ..In particular, GH replacement dose, to be successful on bone mass and turnover, depends on gender in hypopituitary patients aged below 50 yr...
  82. ncbi Prolactinomas in children and adolescents. Clinical presentation and long-term follow-up
    A Colao
    Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Universita Federico II di Napoli, Naples, Italy
    J Clin Endocrinol Metab 83:2777-80. 1998
    ..In conclusion, the medical treatment with dopaminergic compounds is effective and safe in patients with prolactinoma with onset in childhood, allowing preservation of the anterior pituitary function...
  83. ncbi Beneficial effects of a three-month structured exercise training program on cardiopulmonary functional capacity in young women with polycystic ovary syndrome
    Carlo Vigorito
    Department of Clinical Medicine, University Federico II of Naples, Italy
    J Clin Endocrinol Metab 92:1379-84. 2007
    ..An impaired cardiopulmonary functional capacity was previously demonstrated in PCOS women. No data regarding the effects of a structured exercise training (ET) program on cardiopulmonary functional capacity in PCOS women are available...
  84. ncbi Severe impairment of bone mass and turnover in Cushing's disease: comparison between childhood-onset and adulthood-onset disease
    Carolina Di Somma
    Department of Molecular and Clinical Endocrinology and Oncology, CNR Biomorphological and Functional Sciences, Federico II' University of Naples and Servizio di Endocrinologia Pediatrica, Ospedale Regionale per le Microcitemie, Cagliari, Italy
    Clin Endocrinol (Oxf) 56:153-8. 2002
    ..A strict follow-up of bone mass and turnover is mandatory in all patients with Cushing's disease to prevent fractures later in life and specific treatment for bone loss is strongly suggested...
  85. ncbi The cardiovascular risk of young women with polycystic ovary syndrome: an observational, analytical, prospective case-control study
    Francesco Orio
    Department of Molecular and Clinical Endocrinology and Oncology, University Federico II, Naples, Italy
    J Clin Endocrinol Metab 89:3696-701. 2004
    ..In conclusion, our data show the detrimental effect of PCOS on the cardiovascular system even in young women asymptomatic for cardiac disease...
  86. ncbi Growth hormone treatment prevents loss of lean mass after bariatric surgery in morbidly obese patients: results of a pilot, open, prospective, randomized, controlled study
    Silvia Savastano
    Department of Molecular and Clinical Endocrinology and Oncology, Division of Endocrinology, University Federico II of Naples, 80131 Naples, Italy
    J Clin Endocrinol Metab 94:817-26. 2009
    ..The loss of lean body mass (LBM) negatively influences the outcome in bariatric surgery. Impaired GH secretion is frequent in obese patients...
  87. ncbi Cardiovascular risk in women with polycystic ovary syndrome
    Francesco Giallauria
    Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Naples, Italy
    J Cardiovasc Med (Hagerstown) 9:987-92. 2008
    ....
  88. ncbi Treatment with growth hormone receptor antagonist in acromegaly: effect on cardiac structure and performance
    Rosario Pivonello
    Department of Molecular and Clinical Endocrinology, Federico II University of Naples, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 92:476-82. 2007
    ..The aim of the current study was to evaluate the effect of short-term (6 months) and long-term (18 months) treatment with pegvisomant on cardiac structure and performance in patients with acromegaly...
  89. ncbi Beneficial treatment with risedronate in long-term survivors after allogeneic stem cell transplantation for hematological malignancies
    L Tauchmanova
    Department of Molecular and Clinical Endocrinology and Oncology, University Federico II of Naples, Via S Pansini 5, 80131, Naples, Italy
    Osteoporos Int 14:1013-9. 2003
    ..In conclusion, treatment with risedronate for 12 months increased BMD significantly at the lumbar spine and prevented further bone loss at the femoral neck in long-term survivors after allo-SCT...
  90. ncbi Androgens in polycystic ovary syndrome: the role of exercise and diet
    Francesco Giallauria
    Department of Clinical Medicine, Cardiovascular and Immunological Sciences, University of Naples Federico II, Naples, Italy
    Semin Reprod Med 27:306-15. 2009
    ....
  91. ncbi Six months of treatment with cabergoline restores sexual potency in hyperprolactinemic males: an open longitudinal study monitoring nocturnal penile tumescence
    Michele De Rosa
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, 80131 Naples, Italy
    J Clin Endocrinol Metab 89:621-5. 2004
    ..7% of controls. Six months of treatment with cabergoline normalized testosterone levels in most cases, thus restoring and maintaining during treatment the capability of normal sexual activity in hyperprolactinemic males...
  92. ncbi Metabolic and cardiopulmonary effects of detraining after a structured exercise training programme in young PCOS women
    Francesco Orio
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Naples, Italy
    Clin Endocrinol (Oxf) 68:976-81. 2008
    ..The aim of the present study was to determine if the favourable cardiopulmonary and metabolic benefits induced by exercise training (ET) programme are maintained after its cessation...
  93. ncbi Impairment of bone status in patients with central diabetes insipidus
    R Pivonello
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
    J Clin Endocrinol Metab 83:2275-80. 1998
    ..These findings suggest that, in patients with central diabetes insipidus, bone status analysis is mandatory; and a bone-loss preventing treatment might be beneficial...
  94. ncbi Predictive value of pentagastrin test for preoperative differential diagnosis between C-cell hyperplasia and medullary thyroid carcinoma in patients with moderately elevated basal calcitonin levels
    F Milone
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Via S Pansini 5, Naples, Italy
    Clin Endocrinol (Oxf) 73:85-8. 2010
    ..The objective of this study was to investigate the utility of the PG test for CT in distinguishing CCH from MTC before surgery...
  95. ncbi Evaluation of circulating levels and renal clearance of natural amino acids in patients with Cushing's disease
    A Faggiano
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy
    J Endocrinol Invest 25:142-51. 2002
    ..Normalization of cortisol levels restored the amino acid profile...
  96. ncbi Growth-hormone and prolactin excess
    A Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
    Lancet 352:1455-61. 1998
    ..Moreover, the improvement in the management of acromegaly has enabled the reversal, at least partly, of cardiomyopathy and sleep apnoea, two important risk factors for morbidity and mortality in these patients...
  97. ncbi Exercise training improves autonomic function and inflammatory pattern in women with polycystic ovary syndrome (PCOS)
    Francesco Giallauria
    Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University of Naples, Naples, Italy
    Clin Endocrinol (Oxf) 69:792-8. 2008
    ..Exercise training (ET) favourably modulates cardiopulmonary function and insulin-sensitivity markers in PCOS women. The present study investigated the effects of ET on autonomic function and inflammatory pattern in PCOS women...
  98. ncbi Dopamine receptor expression and function in clinically nonfunctioning pituitary tumors: comparison with the effectiveness of cabergoline treatment
    Rosario Pivonello
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Via Sergio Pansini, 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 89:1674-83. 2004
    ..In conclusion, this study demonstrates D(2) receptor expression and function in nearly 70% of cases, suggesting a role of this drug in the treatment schedule of clinically nonfunctioning pituitary tumors...
  99. ncbi Effect of 2 years of cortisol normalization on the impaired bone mass and turnover in adolescent and adult patients with Cushing's disease: a prospective study
    Carolina Di Somma
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University Naples, Italy
    Clin Endocrinol (Oxf) 58:302-8. 2003
    ..Longer recovery times or additive therapeutic approaches are necessary to maximize peak bone mass in children and restore bone mass in adults with Cushing's disease...
  100. ncbi Nephrolithiasis in Cushing's disease: prevalence, etiopathogenesis, and modification after disease cure
    Antongiulio Faggiano
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
    J Clin Endocrinol Metab 88:2076-80. 2003
    ....
  101. ncbi Early impairment of endothelial structure and function in young normal-weight women with polycystic ovary syndrome
    Francesco Orio
    Department of Molecular and Clinical Endocrinology and Oncology, University Federico II of Naples, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 89:4588-93. 2004
    ..0.5 +/- 0.2 pmol/liter for PCOS patients and controls, respectively).In conclusion, our data show that young, normal-weight, nondyslipidemic, nonhypertensive women with PCOS have an early impairment of endothelial structure and function...