Sergio Cocozza

Summary

Affiliation: Federico II University
Country: Italy

Publications

  1. pmc Uncoupling protein 2 G(-866)A polymorphism: a new gene polymorphism associated with C-reactive protein in type 2 diabetic patients
    Emanuela Lapice
    Department of Clinical and Experimental Medicine, University of Naples Federico II, Napoli, Italy
    Cardiovasc Diabetol 9:68. 2010
  2. ncbi request reprint Methodological aspects of the assessment of gene-nutrient interactions at the population level
    Sergio Cocozza
    Complex Disease Genetics Unit, Department of Cellular and Molecular Biology and Pathology, University Federico II, IEOS CNR, Via S Pansini 5, 80136 Naples, Italy
    Nutr Metab Cardiovasc Dis 17:82-8. 2007
  3. pmc CpG islands undermethylation in human genomic regions under selective pressure
    Sergio Cocozza
    Gruppo Interdipartimentale di Bioinformatica e Biologia Computazionale, Università di Napoli Federico II Università di Salerno, Naples, Italy
    PLoS ONE 6:e23156. 2011
  4. ncbi request reprint Pro12Ala polymorphism of the PPARgamma2 locus modulates the relationship between energy intake and body weight in type 2 diabetic patients
    Olga Vaccaro
    Department of Clinical and Experimental Medicine, University of Naples, Federico II, Via S Pansini 5, 80131 Naples, Italy
    Diabetes Care 30:1156-61. 2007
  5. doi request reprint Epoetin alfa increases frataxin production in Friedreich's ataxia without affecting hematocrit
    Francesco Saccà
    Department of Neurological Sciences, University Federico II, Napoli, NA, Italy
    Mov Disord 26:739-42. 2011
  6. pmc Can telomere shortening in human peripheral blood leukocytes serve as a disease biomarker of Friedreich's ataxia?
    Imma Castaldo
    Department of Cellular and Molecular Biology and Pathology, University of Naples Federico II, Naples, Italy
    Antioxid Redox Signal 18:1303-6. 2013
  7. pmc Simulating gene-gene and gene-environment interactions in complex diseases: Gene-Environment iNteraction Simulator 2
    Michele Pinelli
    Gruppo Interdipartimentale di Bioinformatica e Biologia Computazionale, Università di Napoli Federico II Università di Salerno, Italy
    BMC Bioinformatics 13:132. 2012
  8. pmc Schizophrenia and vitamin D related genes could have been subject to latitude-driven adaptation
    Roberto Amato
    Gruppo Interdipartimentale di Bioinformatica e Biologia Computazionale, Università di Napoli Federico II Università di Salerno, Naples, Italy
    BMC Evol Biol 10:351. 2010
  9. pmc Genome-wide scan for signatures of human population differentiation and their relationship with natural selection, functional pathways and diseases
    Roberto Amato
    Gruppo Interdipartimentale di Bioinformatica e Biologia Computazionale, Università di Napoli Federico II Università di Salerno, Naples, Italy
    PLoS ONE 4:e7927. 2009
  10. doi request reprint PPAR-gamma agonist Azelaoyl PAF increases frataxin protein and mRNA expression: new implications for the Friedreich's ataxia therapy
    Daniele Marmolino
    Department of Cellular and Molecular Biology, IEOS CNR, University of Naples Federico II, Naples, Italy
    Cerebellum 8:98-103. 2009

Collaborators

Detail Information

Publications19

  1. pmc Uncoupling protein 2 G(-866)A polymorphism: a new gene polymorphism associated with C-reactive protein in type 2 diabetic patients
    Emanuela Lapice
    Department of Clinical and Experimental Medicine, University of Naples Federico II, Napoli, Italy
    Cardiovasc Diabetol 9:68. 2010
    ..This study evaluated the relationship between the G(-866)A polymorphism of the uncoupling protein 2 (UCP2) gene and high-sensitivity C reactive protein (hs-CRP) plasma levels in diabetic patients...
  2. ncbi request reprint Methodological aspects of the assessment of gene-nutrient interactions at the population level
    Sergio Cocozza
    Complex Disease Genetics Unit, Department of Cellular and Molecular Biology and Pathology, University Federico II, IEOS CNR, Via S Pansini 5, 80136 Naples, Italy
    Nutr Metab Cardiovasc Dis 17:82-8. 2007
    ..A synergy between traditional and nontraditional statistical approaches could be useful...
  3. pmc CpG islands undermethylation in human genomic regions under selective pressure
    Sergio Cocozza
    Gruppo Interdipartimentale di Bioinformatica e Biologia Computazionale, Università di Napoli Federico II Università di Salerno, Naples, Italy
    PLoS ONE 6:e23156. 2011
    ..Our findings suggest that the CpG islands in regions under selective pressure seem to be somehow more "protected" from methylation when compared with other regions of the genome...
  4. ncbi request reprint Pro12Ala polymorphism of the PPARgamma2 locus modulates the relationship between energy intake and body weight in type 2 diabetic patients
    Olga Vaccaro
    Department of Clinical and Experimental Medicine, University of Naples, Federico II, Via S Pansini 5, 80131 Naples, Italy
    Diabetes Care 30:1156-61. 2007
    ..We explore the relationship among BMI, habitual diet, and the Pro12Ala polymorphism in the peroxisome proliferator-activated receptor (PPAR)gamma2...
  5. doi request reprint Epoetin alfa increases frataxin production in Friedreich's ataxia without affecting hematocrit
    Francesco Saccà
    Department of Neurological Sciences, University Federico II, Napoli, NA, Italy
    Mov Disord 26:739-42. 2011
    ..In addition, no hemoglobin increase was observed, and none of our patients required phlebotomy, indicating lack of erythropoietic effect of single high dose of erythropoietin...
  6. pmc Can telomere shortening in human peripheral blood leukocytes serve as a disease biomarker of Friedreich's ataxia?
    Imma Castaldo
    Department of Cellular and Molecular Biology and Pathology, University of Naples Federico II, Naples, Italy
    Antioxid Redox Signal 18:1303-6. 2013
    ..001). Our observations lead to the hypothesis that the TL of human peripheral blood leukocytes may serve as a biomarker of Friedreich's ataxia that could be used as an outcome measure in clinical trials...
  7. pmc Simulating gene-gene and gene-environment interactions in complex diseases: Gene-Environment iNteraction Simulator 2
    Michele Pinelli
    Gruppo Interdipartimentale di Bioinformatica e Biologia Computazionale, Università di Napoli Federico II Università di Salerno, Italy
    BMC Bioinformatics 13:132. 2012
    ....
  8. pmc Schizophrenia and vitamin D related genes could have been subject to latitude-driven adaptation
    Roberto Amato
    Gruppo Interdipartimentale di Bioinformatica e Biologia Computazionale, Università di Napoli Federico II Università di Salerno, Naples, Italy
    BMC Evol Biol 10:351. 2010
    ..Nevertheless, also several diseases show latitudinal clinals such as hypertension, cancer, dismetabolic conditions, schizophrenia, Parkinson's disease and many more...
  9. pmc Genome-wide scan for signatures of human population differentiation and their relationship with natural selection, functional pathways and diseases
    Roberto Amato
    Gruppo Interdipartimentale di Bioinformatica e Biologia Computazionale, Università di Napoli Federico II Università di Salerno, Naples, Italy
    PLoS ONE 4:e7927. 2009
    ..These results can help to identify which process occurred during human evolution and adaptation to different environments. They also support the hypothesis that common diseases could have a genetic background shaped by human evolution...
  10. doi request reprint PPAR-gamma agonist Azelaoyl PAF increases frataxin protein and mRNA expression: new implications for the Friedreich's ataxia therapy
    Daniele Marmolino
    Department of Cellular and Molecular Biology, IEOS CNR, University of Naples Federico II, Naples, Italy
    Cerebellum 8:98-103. 2009
    ..We hypothesize that PPAR-gamma agonists could play a role in the treatment of FRDA, and our results offer the logical bases to further investigate the usefulness of this group of agents for the treatment of the FRDA...
  11. pmc CpG islands under selective pressure are enriched with H3K4me3, H3K27ac and H3K36me3 histone modifications
    Most Mauluda Akhtar
    Gruppo Interdipartimentale di Bioinformatica e Biologia Computazionale, Università di Napoli Federico II Università di Salerno, Naples, Italy
    BMC Evol Biol 13:145. 2013
    ..In particular, histone modifications in CpG islands (CGIs) are associated with different chromatin states and with transcription activity. Changes in gene expression play a crucial role in adaptation and evolution...
  12. pmc Signs of selective pressure on genetic variants affecting human height
    Roberto Amato
    Gruppo Interdipartimentale di Bioinformatica e Biologia Computazionale, Università di Napoli Federico II Università di Salerno, Naples, Italy
    PLoS ONE 6:e27588. 2011
    ....
  13. pmc A novel approach to simulate gene-environment interactions in complex diseases
    Roberto Amato
    Gruppo Interdipartimentale di Bioinformatica e Biologia Computazionale, Università di Napoli Federico II Università di Salerno, Italy
    BMC Bioinformatics 11:8. 2010
    ..To this aim, a possible strategy is to challenge the different statistical methods against data sets where the underlying phenomenon is completely known and fully controllable, for example simulated ones...
  14. pmc A combined nucleic acid and protein analysis in Friedreich ataxia: implications for diagnosis, pathogenesis and clinical trial design
    Francesco Saccà
    Department of Neurological Sciences, University Federico II, Naples, Italy
    PLoS ONE 6:e17627. 2011
    ..No studies have yet reported frataxin protein and mRNA levels in a large cohort of FRDA patients, carriers and controls...
  15. pmc Improving the estimation of celiac disease sibling risk by non-HLA genes
    Valentina Izzo
    Department of Pediatrics, University of Naples Federico II, Naples, Italy
    PLoS ONE 6:e26920. 2011
    ....
  16. pmc Beta2-adrenergic receptor and UCP3 variants modulate the relationship between age and type 2 diabetes mellitus
    Michele Pinelli
    Department of Cellular and Molecular Biology and Pathology A, Califano, University Federico II, Naples, Italy
    BMC Med Genet 7:85. 2006
    ..To achieve this aim we exploited a multianalytical approach also using dimensionality reduction strategy and conservative significance correction strategies...
  17. doi request reprint Increased BDNF promoter methylation in the Wernicke area of suicide subjects
    Simona Keller
    Dipartimento di Biologia e Patologia Cellulare e Molecolare and Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Naples, Italy
    Arch Gen Psychiatry 67:258-67. 2010
    ..So far, the mechanisms leading to downregulation of BDNF expression are poorly understood...
  18. ncbi request reprint Extra-mitochondrial localisation of frataxin and its association with IscU1 during enterocyte-like differentiation of the human colon adenocarcinoma cell line Caco-2
    Fabio Acquaviva
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Via S Pansini 5, Istituto di Endocrinologia ed Oncologia Sperimentale Centro Nazionale delle Ricerche, Universita Federico II, Napoli, Italy
    J Cell Sci 118:3917-24. 2005
    ..These findings might be of relevance for the understanding of both the pathogenesis of Friedreich's ataxia and the basic mechanism of Fe/S cluster biosynthesis...
  19. ncbi request reprint New clues on the origin of the Friedreich ataxia expanded alleles from the analysis of new polymorphisms closely linked to the mutation
    Antonella Monticelli
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, L Califano Università Federico II, Via S Pansini 5, 80131 Naples, Italy
    Hum Genet 114:458-63. 2004
    ..The long normal alleles more frequently showed the 17A haplotype. Our data seem to suggest that all the E alleles come from LN alleles, while LN alleles come from a defined subclass of SN alleles...