Raffaele Capasso

Summary

Affiliation: Federico II University
Country: Italy

Publications

  1. ncbi request reprint Effect of the flavonoid galangin on urinary bladder rat contractility in-vitro
    Raffaele Capasso
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    J Pharm Pharmacol 54:1147-50. 2002
  2. ncbi request reprint Inhibition of rat vas deferens contractions by flavonoids in-vitro
    Raffaele Capasso
    Dipartimento di Farmacologia Sperimentale, Universita degli Studi di Napoli Federico II, via D Montesano 49, 80131 Naples, Italy
    J Pharm Pharmacol 58:381-4. 2006
  3. ncbi request reprint Effects of the herbal formulation ColiMil on upper gastrointestinal transit in mice in vivo
    Raffaele Capasso
    Department of Experimental Pharmacology, University of Naples Federico II, 80131 Naples Italy
    Phytother Res 21:999-1101. 2007
  4. pmc Inhibitory effect of salvinorin A, from Salvia divinorum, on ileitis-induced hypermotility: cross-talk between kappa-opioid and cannabinoid CB(1) receptors
    R Capasso
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Br J Pharmacol 155:681-9. 2008
  5. ncbi request reprint The hallucinogenic herb Salvia divinorum and its active ingredient salvinorin A reduce inflammation-induced hypermotility in mice
    R Capasso
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Neurogastroenterol Motil 20:142-8. 2008
  6. doi request reprint Inhibitory effect of quercetin on rat trachea contractility in vitro
    Raffaele Capasso
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    J Pharm Pharmacol 61:115-9. 2009
  7. ncbi request reprint The hallucinogenic herb Salvia divinorum and its active ingredient salvinorin A inhibit enteric cholinergic transmission in the guinea-pig ileum
    R Capasso
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Neurogastroenterol Motil 18:69-75. 2006
  8. ncbi request reprint Inhibitory effect of the plant flavonoid galangin on rat vas deferens in vitro
    Raffaele Capasso
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131, Naples, Italy
    Life Sci 72:2993-3001. 2003
  9. doi request reprint Inhibitory effect of the herbal antidepressant St. John's wort (Hypericum perforatum) on rat gastric motility
    Raffaele Capasso
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    Naunyn Schmiedebergs Arch Pharmacol 376:407-14. 2008
  10. pmc Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice
    Angelo A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Br J Pharmacol 166:1444-60. 2012

Collaborators

Detail Information

Publications61

  1. ncbi request reprint Effect of the flavonoid galangin on urinary bladder rat contractility in-vitro
    Raffaele Capasso
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    J Pharm Pharmacol 54:1147-50. 2002
    ..It is concluded that the galangin inhibits EFS-induced contractions of the rat urinary bladder by acting on L-type calcium channels on presynaptic nerves...
  2. ncbi request reprint Inhibition of rat vas deferens contractions by flavonoids in-vitro
    Raffaele Capasso
    Dipartimento di Farmacologia Sperimentale, Universita degli Studi di Napoli Federico II, via D Montesano 49, 80131 Naples, Italy
    J Pharm Pharmacol 58:381-4. 2006
    ..Analysis of the chemical structures showed that the saturation of C-2-C-3 double bond and the presence of hydroxyl groups on the flavonoidic scaffold play an important role in the activity of flavonoids...
  3. ncbi request reprint Effects of the herbal formulation ColiMil on upper gastrointestinal transit in mice in vivo
    Raffaele Capasso
    Department of Experimental Pharmacology, University of Naples Federico II, 80131 Naples Italy
    Phytother Res 21:999-1101. 2007
    ..These experimental data may be important to better understand the observation that the herbal formulation ColiMil improves colic in breastfed infants...
  4. pmc Inhibitory effect of salvinorin A, from Salvia divinorum, on ileitis-induced hypermotility: cross-talk between kappa-opioid and cannabinoid CB(1) receptors
    R Capasso
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Br J Pharmacol 155:681-9. 2008
    ....
  5. ncbi request reprint The hallucinogenic herb Salvia divinorum and its active ingredient salvinorin A reduce inflammation-induced hypermotility in mice
    R Capasso
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Neurogastroenterol Motil 20:142-8. 2008
    ..Gut inflammation increased the potency of salvinorin A; this effect was mediated by KOR, but it was not shared by U-50488, thus suggesting that salvinorin A may have target(s) other than KOR in the inflamed gut...
  6. doi request reprint Inhibitory effect of quercetin on rat trachea contractility in vitro
    Raffaele Capasso
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    J Pharm Pharmacol 61:115-9. 2009
    ....
  7. ncbi request reprint The hallucinogenic herb Salvia divinorum and its active ingredient salvinorin A inhibit enteric cholinergic transmission in the guinea-pig ileum
    R Capasso
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Neurogastroenterol Motil 18:69-75. 2006
    ..Salvinorin A might be the chemical ingredient responsible for this activity...
  8. ncbi request reprint Inhibitory effect of the plant flavonoid galangin on rat vas deferens in vitro
    Raffaele Capasso
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131, Naples, Italy
    Life Sci 72:2993-3001. 2003
    ..It is concluded that the galangin inhibits excitatory transmission of the rat vas deferens with a mechanism involving, at least in part, vanilloid receptors...
  9. doi request reprint Inhibitory effect of the herbal antidepressant St. John's wort (Hypericum perforatum) on rat gastric motility
    Raffaele Capasso
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    Naunyn Schmiedebergs Arch Pharmacol 376:407-14. 2008
    ..If extended to humans, the inhibitory effect of SJW extract on gastric emptying in vivo could contribute, at least in part, to the clinical pharmacokinetic interactions between conventional medicines and this herbal antidepressant...
  10. pmc Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice
    Angelo A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Br J Pharmacol 166:1444-60. 2012
    ..Both endocannabinoids and TRPA1 may modulate gastrointestinal motility. Here, we investigated the effect of CBC on mouse intestinal motility in physiological and pathological states...
  11. ncbi request reprint Inhibitory effect of the antidepressant St. John's wort (hypericum perforatum) on rat bladder contractility in vitro
    Raffaele Capasso
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Urology 64:168-72. 2004
    ..To evaluate the effect of St. John's wort (SJW), an effective and safe herbal antidepressant, on rat bladder contractility. Recent data have suggested a strong association between depression and urinary incontinence...
  12. doi request reprint Potent relaxant effect of a Celastrus paniculatus extract in the rat and human ileum
    Francesca Borrelli
    Dipartimento di Farmacologia Sperimentale, Universita degli Studi di Napoli Federico II, Napoli, Italy
    J Ethnopharmacol 122:434-8. 2009
    ..Celastrus paniculatus Willd. (Celastraceae) is an Ayurvedic remedy used for the treatment of a number of diseases, including bowel spasms...
  13. doi request reprint Antispasmodic effects and structure-activity relationships of labdane diterpenoids from Marrubium globosum ssp. libanoticum
    Daniela Rigano
    Department of Chemistry of Natural Products, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    J Nat Prod 72:1477-81. 2009
    ..Compound 9, which exerted antispasmodic activity, is likely the active ingredient of the extract. Preliminary structure-activity relationships for this class of compounds are suggested...
  14. pmc Effect of Boswellia serrata on intestinal motility in rodents: inhibition of diarrhoea without constipation
    Francesca Borrelli
    Department of Experimental Pharmacology, University of Naples Federico II, Italy
    Br J Pharmacol 148:553-60. 2006
    ..These results could explain, at least in part, the clinical efficacy of this Ayurvedic remedy in reducing diarrhoea in patients with inflammatory bowel disease...
  15. doi request reprint Basal and fasting/refeeding-regulated tissue levels of endogenous PPAR-alpha ligands in Zucker rats
    Angelo A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Obesity (Silver Spring) 18:55-62. 2010
    ..Changes in PEA levels might be relevant to the inflammatory state of Zucker rats...
  16. ncbi request reprint Identification of a new sesquiterpene polyol ester from Celastrus paniculatus
    Nicola Borbone
    Dipartimento di Chimica delle Sostanze Naturali, Universita degli Studi di Napoli Federico II, Napoli, Italy
    Planta Med 73:792-4. 2007
    ..All four compounds produce at a concentration of 1 microg/mL a relaxant effect on the isolated rat ileum of 31.4 +/- 7.5, 24.3 +/- 9.6, 24.4 +/- 4.9, and 16.2 +/- 7.2 %, respectively...
  17. doi request reprint Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in a murine model of colitis
    Francesca Borrelli
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    J Mol Med (Berl) 87:1111-21. 2009
    ..In Caco-2 cells, cannabidiol reduced reactive oxygen species production and lipid peroxidation. In conclusion, cannabidiol, a likely safe compound, prevents experimental colitis in mice...
  18. pmc Potent antioxidant and genoprotective effects of boeravinone G, a rotenoid isolated from Boerhaavia diffusa
    Gabriella Aviello
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    PLoS ONE 6:e19628. 2011
    ..e. boeravinones) isolated from the roots of Boerhaavia diffusa, a plant used in the Ayurvedic medicine for the treatment of diseases affecting the gastrointestinal tract...
  19. doi request reprint Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease
    Francesca Borrelli
    Department of Pharmacy, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    Biochem Pharmacol 85:1306-16. 2013
    ..CBG could be considered for clinical experimentation in IBD patients...
  20. pmc Increased endocannabinoid levels reduce the development of precancerous lesions in the mouse colon
    Angelo A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    J Mol Med (Berl) 86:89-98. 2008
    ..The protective effect appears to involve caspase-3 (but not caspase-9) activation...
  21. ncbi request reprint A diterpenoid from Salvia cinnabarina inhibits mouse intestinal motility in vivo
    Raffaele Capasso
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    Planta Med 70:375-7. 2004
    ..p.) significantly reduced the antimotility effect of compound 1 (50 mg/kg). These results suggest that compound 1 inhibits gastrointestinal motility in mice. The effect could involve, at least in part, L-type Ca (2+) channels...
  22. doi request reprint Inhibitory effect of caffeic acid phenethyl ester, a plant-derived polyphenolic compound, on rat intestinal contractility
    Gabriella Aviello
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    Eur J Pharmacol 640:163-7. 2010
    ..In conclusion our study shows that (i) CAPE relaxed myogenic contractions of rat ileum and that (ii) this effect occurs, at least in part, throughout a mechanism involving L-type Ca2+ channels...
  23. ncbi request reprint Inhibitory effect of ginger (Zingiber officinale) on rat ileal motility in vitro
    Francesca Borrelli
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    Life Sci 74:2889-96. 2004
    ....
  24. doi request reprint Inhibitory effect of the anorexic compound oleoylethanolamide on gastric emptying in control and overweight mice
    Gabriella Aviello
    Endocannabinoid Research Group, Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    J Mol Med (Berl) 86:413-22. 2008
    ..The inhibitory effect of OEA on gastric emptying here observed might underlie part of the anorexic effects of this compound previously reported...
  25. ncbi request reprint A secoisopimarane diterpenoid from Salvia cinnabarina inhibits rat urinary bladder contractility in vitro
    Raffaele Capasso
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Planta Med 70:185-8. 2004
    ..It is concluded that compound 1 inhibits rat bladder contractility with a mechanism involving, at least in part, NO production...
  26. ncbi request reprint Fatty acid amide hydrolase controls mouse intestinal motility in vivo
    Raffaele Capasso
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Gastroenterology 129:941-51. 2005
    ..The physiologic role of FAAH in the gut is largely unexplored. In the present study, we evaluated the possible role of FAAH in regulating intestinal motility in mice in vivo...
  27. pmc Peripheral endocannabinoid dysregulation in obesity: relation to intestinal motility and energy processing induced by food deprivation and re-feeding
    Angelo A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Br J Pharmacol 158:451-61. 2009
    ..Here we evaluate endocannabinoid dysregulation in the small intestine of mice with diet-induced obesity (DIO) and in peripheral tissues of Zucker and lean rats following food deprivation and re-feeding...
  28. doi request reprint Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer
    Gabriella Aviello
    Department of Experimental Pharmacology, Endocannabinoid Research Group, University of Naples Federico II, Naples, Italy
    J Mol Med (Berl) 90:925-34. 2012
    ..It is concluded that cannabidiol exerts chemopreventive effect in vivo and reduces cell proliferation through multiple mechanisms...
  29. pmc Modulation of mouse gastrointestinal motility by allyl isothiocyanate, a constituent of cruciferous vegetables (Brassicaceae): evidence for TRPA1-independent effects
    Raffaele Capasso
    Department of Experimental Pharmacology, Endocannabinoid Research Group, University of Naples Federico II, Naples, Italy
    Br J Pharmacol 165:1966-77. 2012
    ..In this study, we have investigated the effect of AITC on intestinal motility...
  30. ncbi request reprint Spasmolytic effects of nonprenylated rotenoid constituents of Boerhaavia diffusa roots
    Francesca Borrelli
    Dipartimento di Farmacologia Sperimentale, Universita di Napoli Federico II, via D Montesano 49, 80131 Napoli, Italy
    J Nat Prod 69:903-6. 2006
    ..Preliminary structure-activity relationships for this class of compounds are suggested...
  31. doi request reprint Inhibitory effect of standardized cannabis sativa extract and its ingredient cannabidiol on rat and human bladder contractility
    Raffaele Capasso
    Department of Experimental Pharmacology and Endocannabinoid Research Group, University of Naples Federico II, Naples, Italy
    Urology 77:1006.e9-1006.e15. 2011
    ..Cannabis based-medicines, including CBD-enriched extracts, have been shown to reduce urinary urgency, incontinence episodes, frequency, and nocturia in patients with multiple sclerosis...
  32. ncbi request reprint Relaxant effect of capsazepine in the isolated rat ileum
    Emilia Nocerino
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    Naunyn Schmiedebergs Arch Pharmacol 365:187-92. 2002
    ..We found no evidence to suggest that capsazepine is antagonizing an endogenous vanilloid...
  33. ncbi request reprint Vascular effects of caffeic acid phenethyl ester (CAPE) on isolated rat thoracic aorta
    Carla Cicala
    Dipartimento di Farmacologia Sperimentale, Universita degli Studi di Napoli Federico II, via D Montesano 49, 80131 Napoli, Italy
    Life Sci 73:73-80. 2003
    ..Indeed, at high concentrations, CAPE vasorelaxant effect occurs also in absence of endothelium and it is likely due to an inhibitory effect on calcium movements through cell membranes...
  34. ncbi request reprint Isolation of new rotenoids from Boerhaavia diffusa and evaluation of their effect on intestinal motility
    Francesca Borrelli
    Dipartimento di Farmacologia Sperimentale, Universita di Napoli Federico II, via D Montesano 49, 80131 Naples, Italy
    Planta Med 71:928-32. 2005
    ..Three of them (boeravinone G, boeravinone E and compound 5) exhibited spasmolytic activity. Preliminary structure-activity relationships have been established highlighting the effect of substitutions on rings B and D...
  35. ncbi request reprint Garlic: empiricism or science?
    Gabriella Aviello
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Nat Prod Commun 4:1785-96. 2009
    ..However, the clinical evidence is far from compelling. Garlic appears to be generally safe although allergic reactions may occur...
  36. ncbi request reprint Effect of caffeic acid phenethyl ester on gastric acid secretion in vitro
    Francesca Borrelli
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131, Naples, Italy
    Eur J Pharmacol 521:139-43. 2005
    ..Our results show that CAPE increases gastric acid secretion stimulated by an acetylcholine agonist receptor likely through inhibition of acetylcholinesterase activity...
  37. doi request reprint Ultrapotent effects of salvinorin A, a hallucinogenic compound from Salvia divinorum, on LPS-stimulated murine macrophages and its anti-inflammatory action in vivo
    Gabriella Aviello
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano, 49, 80131 Naples, Italy
    J Mol Med (Berl) 89:891-902. 2011
    ..It is concluded that salvinorin A-via KORs and CB1 receptors-exerts ultrapotent actions on macrophages and also shows moderate antinflammatory effects in vivo...
  38. ncbi request reprint An endogenous cannabinoid tone attenuates cholera toxin-induced fluid accumulation in mice
    Angelo A Izzo
    Department of Experimental Pharmacology, University of Naples, Frederico II, Naples, Italy
    Gastroenterology 125:765-74. 2003
    ..In this study, we investigated the role of the endogenous cannabinoid system (i.e., the cannabinoid receptors and their endogenous ligands) in CT-induced fluid accumulation in the mouse small intestine...
  39. doi request reprint Silymarin BIO-C, an extract from Silybum marianum fruits, induces hyperprolactinemia in intact female rats
    Raffaele Capasso
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Phytomedicine 16:839-44. 2009
    ..In conclusion, we have shown that an extract from S. marianum fruits significantly increases circulating prolactin levels in female rats; this effect seems to involve, at least in part, dopamine D(2) receptors...
  40. ncbi request reprint New sesquiterpenes with intestinal relaxant effect from Celastrus paniculatus
    Francesca Borrelli
    Dipartimento di Farmacologia Sperimentale, Universita degli Studi di Napoli Federico II, via D Montesano 49, 80131 Naples, Italy
    Planta Med 70:652-6. 2004
    ..6 +/- 12.2 %, 26.9 +/- 4.7 % and 7.27 +/- 1.7 %, respectively...
  41. ncbi request reprint Phytochemical and pharmacological studies on the acetonic extract of Marrubium globosum ssp. libanoticum
    Daniela Rigano
    Department of Chemistry of Natural Products, University of Naples Federico II, Naples, Italy
    Planta Med 72:575-8. 2006
    ..globosum exerts anti-inflammatory effects in the rat paw oedema induced by carrageenin resulting in reduced paw swelling. This activity, which seems due to marrulibanoside, is a consequence of iNOS and COX-2 activities inhibition...
  42. pmc Salvinorin A reduces mechanical allodynia and spinal neuronal hyperexcitability induced by peripheral formalin injection
    Francesca Guida
    Department of Experimental Medicine, Section of Pharmacology, The Second University of Naples, Naples, Italy
    Mol Pain 8:60. 2012
    ..Moreover, the involvement of microglial and glial cells in formalin-induced chronic pain condition and in SA-mediated effects has been evaluated...
  43. ncbi request reprint Effectiveness and safety of ginger in the treatment of pregnancy-induced nausea and vomiting
    Francesca Borrelli
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Obstet Gynecol 105:849-56. 2005
    ..This systematic review was aimed at assessing the evidence for or against the efficacy and safety of ginger (Zingiber officinale) therapy for nausea and vomiting during pregnancy...
  44. doi request reprint Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb
    Angelo A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Trends Pharmacol Sci 30:515-27. 2009
    ....
  45. ncbi request reprint Garlic (Allium sativum L.): adverse effects and drug interactions in humans
    Francesca Borrelli
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Mol Nutr Food Res 51:1386-97. 2007
    ..Finally, garlic may enhance the pharmacological effect of anticoagulants (e. g. warfarin, fluindione) and reduce the efficacy of anti-AIDS drugs (i. e. saquinavir)...
  46. doi request reprint Anti-proliferative effect of rhein, an anthraquinone isolated from Cassia species, on Caco-2 human adenocarcinoma cells
    Gabriella Aviello
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    J Cell Mol Med 14:2006-14. 2010
    ..Finally, rhein prevents the DNA damage probably via an anti-oxidant mechanism...
  47. ncbi request reprint Modulation of apoptosis in mice treated with Echinacea and St. John's wort
    Giulia Di Carlo
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    Pharmacol Res 48:273-7. 2003
    ....
  48. ncbi request reprint Natural products of mineral origin
    Massimiliano Laudato
    Department of Pharmacy, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    Nat Prod Commun 8:419-23. 2013
    ..Some evidence still suggests potential benefit of these substances. Therefore, this paper reviews the characteristic features of the respective minerals and their salts along the course of studies on these products...
  49. ncbi request reprint Effect of piperine, the active ingredient of black pepper, on intestinal secretion in mice
    Raffaele Capasso
    Department of Pharmaceutical Science, University of Salerno, Italy
    Life Sci 71:2311-7. 2002
    ..p.). These results suggest that piperine reduces castor oil-induced fluid secretion with a mechanism involving capsaicin-sensitive neurons, but not capsazepine-sensitive vanilloid receptors...
  50. ncbi request reprint Minor diterpenoids from cascarilla (Croton eluteria Bennet) and evaluation of the cascarilla extract and cascarillin effects on gastric acid secretion
    Giovanni Appendino
    Dipartimento di Chimica delle Sostanze Naturali, Universita di Napoli Federico II, via D Montesano 49, 80131 Napoli, Italy
    J Agric Food Chem 51:6970-4. 2003
    ..These preliminary results provide the first rationale for the use of cascarilla in bitter preparations aimed at improving digestion...
  51. ncbi request reprint Conicamin, a novel histamine antagonist from the mediterranean tunicate Aplidium conicum
    Anna Aiello
    Dipartimento di Chimica delle Sostanze Naturali, via D Montesano, 49, I 80131 Napoli, Italy
    Bioorg Med Chem Lett 13:4481-3. 2003
    ....
  52. ncbi request reprint Nonprenylated rotenoids, a new class of potent breast cancer resistance protein inhibitors
    Abdelhakim Ahmed-Belkacem
    Institut de Biologie et Chimie des Proteines, UMR 5086 CNRS Université Lyon 1, IFR 128 Biosciences Gerland Lyon Sud, 7 passage du Vercors, 69367 Lyon, France
    J Med Chem 50:1933-8. 2007
    ..The present study provides the first data on the BCRP-inhibiting activity of rotenoid derivatives, indicating boeravinones as a new class of interesting BCRP inhibitors...
  53. ncbi request reprint Effects of the antidepressant St. John's wort (Hypericum perforatum) on rat and human vas deferens contractility
    Raffaele Capasso
    Departments of Experimental Pharmacology and Urology, University of Naples Federico II, Naples Italy
    J Urol 173:2194-7. 2005
    ..John's wort (SJW) (Hypericum perforatum) we evaluated the effect of this herbal antidepressant on rat and human vas deferens contractility...
  54. ncbi request reprint Synthesis by microwave irradiation and antidiarrhoeal activity of benzotriazinone and saccharine derivatives
    Ferdinando Fiorino
    Dipartimento di Chimica Farmaceutica e Tossicologica, Universita Degli Studi Di Napoli, Federico II, Napoli, Italy
    Arch Pharm (Weinheim) 338:548-55. 2005
    ..Good yields and short reaction times are the main advantages of our synthetic route. Among the tested compounds, compound 12 inhibited motility both in in-vitro and in-vivo tests...
  55. ncbi request reprint Structure-activity relationships for saponins from Allium hirtifolium and Allium elburzense and their antispasmodic activity
    Elisa Barile
    DISTAAM, Università degli Studi del Molise, Campobasso, Italy
    Planta Med 71:1010-8. 2005
    ..The observed effect therefore contributes to the explanation of the traditional use of onion and garlic in the treatment of disturbances of the gastrointestinal tract...
  56. ncbi request reprint The sapogenin atroviolacegenin and its diglycoside atroviolaceoside from Allium atroviolaceum
    Behzad Zolfaghari
    Department of Pharmacognosy, Isfahan University of Medical Sciences, Hezar Jerib Avenue, 73461 Isfahan, Iran
    J Nat Prod 69:191-5. 2006
    ..The absence of activity for both atroviolacegenin and atroviolaceoside highlighted the key role of the furostanol-type aglycone moiety for antispasmodic activity...
  57. ncbi request reprint Antispasmodic saponins from bulbs of red onion, Allium cepa L. var. Tropea
    Gabriella Corea
    Dipartimento di Chimica delle Sostanze Naturali, Universita di Napoli Federico II, via D Montesano 49, I 80131 Napoli, Italy
    J Agric Food Chem 53:935-40. 2005
    ..The new saponins were found to possess antispasmodic activity in the guinea pig isolated ileum; such an effect might contribute to explaining the traditional use of onion in the treatment of disturbances of the gastrointestinal tract...
  58. ncbi request reprint Synthesis and pharmacological activity of 2-(substituted)-3-{2-[(4-phenyl-4-cyano)piperidino]ethyl}-1,3-thiazolidin-4-ones
    Orazio Mazzoni
    Dipartimento di Chimica Farmaceutica e Tossicologica, Universita di Napoli Federico II, via D Montesano 49, 80131 Napoli, Italia
    Chem Biol Drug Des 67:432-6. 2006
    ..The results obtained by this study, suggest that the antidiarrhoeal activity of this series of thiazolidinone derivatives could involve the opioid receptors...
  59. ncbi request reprint Herbal medicine: the dangers of drug interaction
    Angelo A Izzo
    Trends Pharmacol Sci 23:358-91; author reply 359. 2002
  60. doi request reprint Endocannabinoid dysregulation in the pancreas and adipose tissue of mice fed with a high-fat diet
    Katarzyna M Starowicz
    Endocannabinoid Research Group, Consiglio Nazionale delle Ricerche, Pozzuoli, Italy
    Obesity (Silver Spring) 16:553-65. 2008
    ..Their pancreatic and adipose tissue levels are elevated during hyperglycemia and obesity, but the mechanisms underlying these alterations are not understood...
  61. doi request reprint Dysregulation of peripheral endocannabinoid levels in hyperglycemia and obesity: Effect of high fat diets
    Isabel Matias
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Pozzuoli NA, Italy
    Mol Cell Endocrinol 286:S66-78. 2008
    ..The potential implications of these and previous findings in the general framework of the proposed roles of the EC system in the control of metabolic, endocrine and cardiovascular and renal functions are discussed...