Affiliation: Federico II University
Caliendo G, Fiorino F, Perissutti E, Severino B, Scolaro D, Gessi S, et al
. A convenient synthesis by microwave heating and pharmacological evaluation of novel benzoyltriazole and saccharine derivatives as 5-HT(1A) receptor ligands. Eur J Pharm Sci. 2002;16:15-28 pubmed
..All compounds displayed moderate affinity for 5-HT(1A) receptor. The most interesting compound 33 showed a high affinity (K(i)=93 nM) which was combined with no affinity on the other receptors considered. ..
Caliendo G, Santagada V, Perissutti E, Fiorino F. Derivatives as 5HT1A receptor ligands--past and present. Curr Med Chem. 2005;12:1721-53 pubmed
..In this review, we report an overview of the 5-HT1A receptor ligands, belonging to different chemical classes. ..
Caliendo G, Santagada V, Perissutti E, Severino B, Fiorino F, Frecentese F, et al
. Kallikrein protease activated receptor (PAR) axis: an attractive target for drug development. J Med Chem. 2012;55:6669-86 pubmed publisher
Caliendo G, Cirino G, Santagada V, Wallace J. Synthesis and biological effects of hydrogen sulfide (H2S): development of H2S-releasing drugs as pharmaceuticals. J Med Chem. 2010;53:6275-86 pubmed publisher
Corvino A, Rosa R, Incisivo G, Fiorino F, Frecentese F, Magli E, et al
. Development of 1,2,3-Triazole-Based Sphingosine Kinase Inhibitors and Their Evaluation as Antiproliferative Agents. Int J Mol Sci. 2017;18: pubmed publisher
..Compounds 5h and 8f, identified as the most efficient antiproliferative agents, showed a different selectivity profile, with 8f being selective for SphK1. ..