G Brevetti

Summary

Affiliation: Federico II University
Country: Italy

Publications

  1. ncbi Concomitant coronary and peripheral arterial disease: relationship between the inflammatory status of the affected limb and the severity of coronary artery disease
    Gregorio Brevetti
    Department of Clinical Medicine, Cardiovascular, and Immunological Sciences, University of Naples Federico II, Naples, Italy
    J Vasc Surg 49:1465-71. 2009
  2. ncbi Cellular adhesion molecules and peripheral arterial disease
    Gregorio Brevetti
    Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University Federico II, Napoli, Italy
    Vasc Med 11:39-47. 2006
  3. ncbi Metabolic syndrome in peripheral arterial disease: relationship with severity of peripheral circulatory insufficiency, inflammatory status, and cardiovascular comorbidity
    Gregorio Brevetti
    Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Naples Federico II, Naples, Italy
    J Vasc Surg 44:101-7; discussion 107. 2006
  4. ncbi Peripheral arterial disease and cardiovascular risk in Italy. Results of the Peripheral Arteriopathy and Cardiovascular Events (PACE) study
    Gregorio Brevetti
    Department of Clinical Medicine and Cardiovascular and Immunological Sciences, Federico II University of Naples, Italy
    J Cardiovasc Med (Hagerstown) 7:608-13. 2006
  5. doi Metabolic syndrome and cardiovascular risk prediction in peripheral arterial disease
    G Brevetti
    Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Naples Federico II, Italy
    Nutr Metab Cardiovasc Dis 20:676-82. 2010
  6. pmc Mortality in peripheral arterial disease: a comparison of patients managed by vascular specialists and general practitioners
    Gregorio Brevetti
    Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Napoli Federico II, Naples, Italy
    J Gen Intern Med 22:639-44. 2007
  7. ncbi [Intermittent claudication in Italy. The Peripheral Arteriopathy and Cardiovascular Events (PACE) study]
    Gregorio Brevetti
    Dipartimento di Medicina Clinica, Scienze Cardiovascolari e Immunologiche, Universita degli Studi Federico II, Napoli
    G Ital Cardiol (Rome) 8:34-42. 2007
  8. ncbi [Infrarenal abdominal aortic aneurysms]
    Gregorio Brevetti
    Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Universita degli Studi Federico II, Napoli
    G Ital Cardiol (Rome) 8:543-51. 2007
  9. ncbi Endothelial dysfunction: a key to the pathophysiology and natural history of peripheral arterial disease?
    Gregorio Brevetti
    Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Naples Federico II, Via G Iannelli 45 A, 80131 Napoli, Italy
    Atherosclerosis 197:1-11. 2008
  10. ncbi The prevalence of hypoechoic carotid plaques is greater in peripheral than in coronary artery disease and is related to the neutrophil count
    Gregorio Brevetti
    Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Napoli Federico II, Napoli, Italy
    J Vasc Surg 47:523-9. 2008

Collaborators

Detail Information

Publications47

  1. ncbi Concomitant coronary and peripheral arterial disease: relationship between the inflammatory status of the affected limb and the severity of coronary artery disease
    Gregorio Brevetti
    Department of Clinical Medicine, Cardiovascular, and Immunological Sciences, University of Naples Federico II, Naples, Italy
    J Vasc Surg 49:1465-71. 2009
    ..We investigated the relationship between the inflammatory status in the affected limb and CAD severity...
  2. ncbi Cellular adhesion molecules and peripheral arterial disease
    Gregorio Brevetti
    Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University Federico II, Napoli, Italy
    Vasc Med 11:39-47. 2006
    ....
  3. ncbi Metabolic syndrome in peripheral arterial disease: relationship with severity of peripheral circulatory insufficiency, inflammatory status, and cardiovascular comorbidity
    Gregorio Brevetti
    Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Naples Federico II, Naples, Italy
    J Vasc Surg 44:101-7; discussion 107. 2006
    ..In patients with peripheral arterial disease (PAD), we investigated the prevalence of metabolic syndrome and its relationship with the severity of peripheral circulatory insufficiency, inflammatory status, and cardiovascular comorbidity...
  4. ncbi Peripheral arterial disease and cardiovascular risk in Italy. Results of the Peripheral Arteriopathy and Cardiovascular Events (PACE) study
    Gregorio Brevetti
    Department of Clinical Medicine and Cardiovascular and Immunological Sciences, Federico II University of Naples, Italy
    J Cardiovasc Med (Hagerstown) 7:608-13. 2006
    ..This study was aimed at defining mortality and cardiovascular morbidity of PAD patients in Italy...
  5. doi Metabolic syndrome and cardiovascular risk prediction in peripheral arterial disease
    G Brevetti
    Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Naples Federico II, Italy
    Nutr Metab Cardiovasc Dis 20:676-82. 2010
    ..Metabolic syndrome (MetS) was reported to be associated with increased cardiovascular risk in various settings, however its prognostic impact in peripheral arterial disease (PAD) is scanty...
  6. pmc Mortality in peripheral arterial disease: a comparison of patients managed by vascular specialists and general practitioners
    Gregorio Brevetti
    Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Napoli Federico II, Naples, Italy
    J Gen Intern Med 22:639-44. 2007
    ..Peripheral arterial disease (PAD) is undertreated by general practitioners (GPs). However, the impact of the suboptimal clinical management is unknown...
  7. ncbi [Intermittent claudication in Italy. The Peripheral Arteriopathy and Cardiovascular Events (PACE) study]
    Gregorio Brevetti
    Dipartimento di Medicina Clinica, Scienze Cardiovascolari e Immunologiche, Universita degli Studi Federico II, Napoli
    G Ital Cardiol (Rome) 8:34-42. 2007
    ....
  8. ncbi [Infrarenal abdominal aortic aneurysms]
    Gregorio Brevetti
    Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Universita degli Studi Federico II, Napoli
    G Ital Cardiol (Rome) 8:543-51. 2007
    ..Symptomatic aneurysms present with back, abdominal, or leg pain and require urgent surgical attention. Rupture of an AAA involves complete loss of aortic wall integrity and is a surgical emergency requiring immediate repair...
  9. ncbi Endothelial dysfunction: a key to the pathophysiology and natural history of peripheral arterial disease?
    Gregorio Brevetti
    Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Naples Federico II, Via G Iannelli 45 A, 80131 Napoli, Italy
    Atherosclerosis 197:1-11. 2008
    ..Large clinical trials are needed to verify whether affected individuals with depressed endothelial function benefit from specific treatments...
  10. ncbi The prevalence of hypoechoic carotid plaques is greater in peripheral than in coronary artery disease and is related to the neutrophil count
    Gregorio Brevetti
    Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Napoli Federico II, Napoli, Italy
    J Vasc Surg 47:523-9. 2008
    ..To date, no study has compared these two populations with respect to plaque echogenicity, which is an independent risk factor for cerebrovascular events...
  11. doi Women and peripheral arterial disease: same disease, different issues
    Gregorio Brevetti
    Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Naples Federico II, Naples, Italy
    J Cardiovasc Med (Hagerstown) 9:382-8. 2008
    ..The present study aimed to examine sex differences in peripheral arterial disease (PAD) and its clinical correlates...
  12. doi In concomitant coronary and peripheral arterial disease, inflammation of the affected limbs predicts coronary artery endothelial dysfunction
    Gregorio Brevetti
    Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Naples Federico II, Naples, Italy
    Atherosclerosis 201:440-6. 2008
    ..We investigated whether the inflammatory status of affected limbs impairs coronary artery endothelial function (CAEF)...
  13. doi IGF system and peripheral arterial disease: relationship with disease severity and inflammatory status of the affected limb
    Gregorio Brevetti
    Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Naples Federico II, Naples, Italy
    Clin Endocrinol (Oxf) 69:894-900. 2008
    ..IGF-1 and its binding proteins are involved in the pathogenesis of atherosclerosis. We designed this study to unravel the relationship of the IGF system with peripheral arterial disease (PAD)...
  14. doi The impact of comorbidity burden on the cardiovascular risk in the Peripheral Arteriopathy and Cardiovascular Events study
    G Brevetti
    Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Naples Federico II, Naples, Italy
    QJM 101:575-82. 2008
    ..A comprehensive evaluation of comorbidity is important in predicting outcome of patients affected by a chronic disease because of the role of competing risk...
  15. doi Prevalence of hypoechoic carotid plaques in coronary artery disease: relationship with coexistent peripheral arterial disease and leukocyte number
    Gregorio Brevetti
    Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Naples Federico II, Naples, Italy
    Vasc Med 14:13-9. 2009
    ..Thus, our data suggest that in CAD+PAD, evaluation of carotid plaque echogenicity could contribute to improve clinical decision-making and differentiate treatments for individual patients...
  16. ncbi Myeloperoxidase, but not C-reactive protein, predicts cardiovascular risk in peripheral arterial disease
    Gregorio Brevetti
    Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Naples Federico II, Via Pansini 5, Naples, Italy
    Eur Heart J 29:224-30. 2008
    ..Accordingly, in these patients we investigated the impact of myeloperoxidase (MPOx) and C-reactive protein on the incidence of myocardial infarction and stroke...
  17. ncbi [A new questionnaire for assessing the quality of life of patients with intermittent claudication]
    A Silvestro
    Dipartimento di Medicina Clinica e Scienze Cardiovascolari ed Immunologiche, Universita degli Studi Federico II, Napoli
    Minerva Cardioangiol 48:455-65. 2000
    ..At present, however, no generic scale fits all criteria for the ideal quality of life measuring in intermittent claudication...
  18. ncbi High levels of adhesion molecules are associated with impaired endothelium-dependent vasodilation in patients with peripheral arterial disease
    G Brevetti
    Department of Medicine, University Federico II, Napoli, Italy
    Thromb Haemost 85:63-6. 2001
    ....
  19. ncbi European multicenter study on propionyl-L-carnitine in intermittent claudication
    G Brevetti
    Department of Medicine, University Federico II, Napoli, Italy
    J Am Coll Cardiol 34:1618-24. 1999
    ..This study was performed to identify a target population of claudicants for propionyl-L-carnitine treatment...
  20. ncbi Exercise increases soluble adhesion molecules ICAM-1 and VCAM-1 in patients with intermittent claudication
    G Brevetti
    Department of Medicine, University FedericoII, Naples, Italy
    Clin Hemorheol Microcirc 24:193-9. 2001
    ..These findings indicate that, in claudicants, exercise is associated with increase in plasma levels of sICAM-1 and sVCAM-1...
  21. ncbi Increased inflammatory status and higher prevalence of three-vessel coronary artery disease in patients with concomitant coronary and peripheral atherosclerosis
    Gregorio Brevetti
    Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University Federico II, Naples, Italy
    Thromb Haemost 89:1058-63. 2003
    ..These results could help to explain the high cardiovascular risk of patients with concomitant CAD and PAD and suggest that PAD be included among the variables used to identify CAD patients for further diagnostic evaluation...
  22. ncbi Intermittent claudication: pharmacoeconomic and quality-of-life aspects of treatment
    Gregorio Brevetti
    Department of Medicine, University Federico II, Naples, Italy
    Pharmacoeconomics 20:169-81. 2002
    ....
  23. ncbi Early vascular alterations in acromegaly
    Gregorio Brevetti
    Department of Medicine, University Federico II, Via G Iannelli 45 A, 80131 Naples, Italy
    J Clin Endocrinol Metab 87:3174-9. 2002
    ..No difference in IMT was observed between active and cured patients. In conclusion, patients with acromegaly have functional and morphological vascular alteration that seems, at least in part, dependent on the GH excess itself...
  24. ncbi Microcirculation and tissue metabolism in peripheral arterial disease
    G Brevetti
    Department of Medicine, University Federico II, Naples, Italy
    Clin Hemorheol Microcirc 21:245-54. 1999
    ....
  25. ncbi Endothelial dysfunction in peripheral arterial disease is related to increase in plasma markers of inflammation and severity of peripheral circulatory impairment but not to classic risk factors and atherosclerotic burden
    Gregorio Brevetti
    Department of Clinical Medicine, University Federico II, Via G Iannelli 45 A, 80131 Naples, Italy
    J Vasc Surg 38:374-9. 2003
    ....
  26. ncbi Endothelial dysfunction and cardiovascular risk prediction in peripheral arterial disease: additive value of flow-mediated dilation to ankle-brachial pressure index
    Gregorio Brevetti
    Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University Federico II, Naples, Italy
    Circulation 108:2093-8. 2003
    ..The study was specially aimed at assessing whether brachial artery flow-mediated dilation (FMD) added to the predictive value of ankle-brachial pressure index (ABPI)...
  27. ncbi Prevalence, risk factors and cardiovascular comorbidity of symptomatic peripheral arterial disease in Italy
    Gregorio Brevetti
    Departments of Clinical Medicine and Cardiovascular and Immunological Sciences, Via G Iannelli 45 A, Naples 80313, Italy
    Atherosclerosis 175:131-8. 2004
    ..Thus, there is need to alert general practitioners to this topic...
  28. ncbi Peripheral arterial disease: the magnitude of the problem and its socioeconomic impact
    Gregorio Brevetti
    Department of Medicine and Cardiovascular and Immunological Sciences, University Federico II, Napoli, Italy
    Curr Drug Targets Cardiovasc Haematol Disord 4:199-208. 2004
    ..e. those related to lost productivity, and reduced quality of life, respectively) could be reduced if the condition were to be recognized and correctly treated at an early stage...
  29. ncbi Relationship between insulin-like growth factor-1 system and exercise tolerance in patients with intermittent claudication
    E Laurenzano
    Department of Clinical Medicine, University of Naples Federico II, Naples, Italy
    Int Angiol 28:202-8. 2009
    ..We aimed the present study at assessing whether IGF-1 system and its changes with exercise are related to walking capacity in intermittent claudication (IC)...
  30. ncbi Inflammatory status and endothelial function in asymptomatic and symptomatic peripheral arterial disease
    Antonio Silvestro
    Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University Federico II, Naples Italy
    Vasc Med 8:225-32. 2003
    ..05). Thus, in PAD, endothelial function and inflammatory status are related to the severity of the circulatory impairment. This finding may contribute to the explanation of the increasingly poor prognosis with increased PAD severity...
  31. doi Omega-3 polyunsaturated fatty acid in peripheral arterial disease: effect on lipid pattern, disease severity, inflammation profile, and endothelial function
    Vittorio Schiano
    Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Naples Federico II, Naples, Italy
    Clin Nutr 27:241-7. 2008
    ..Accordingly, we investigated the effects of omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation on endothelial function and inflammatory status in affected individuals...
  32. doi The prognostic impact of general and abdominal obesity in peripheral arterial disease
    G Giugliano
    Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Naples Federico II, Naples, Italy
    Int J Obes (Lond) 34:280-6. 2010
    ..Accordingly, we assessed the impact of body mass index (BMI) and waist circumference (WC) on cardiovascular risk in a homogeneous cohort of PAD patients...
  33. ncbi Functional status measured by walking impairment questionnaire and cardiovascular risk prediction in peripheral arterial disease: results of the Peripheral Arteriopathy and Cardiovascular Events (PACE) study
    Vittorio Schiano
    Department of Clinical Medicine, University of Naples Federico II, Naples, Italy
    Vasc Med 11:147-54. 2006
    ..26, p = 0.019). In intermittent claudication, a worse functional status entails a greater risk of ischemic events versus low functional impairment...
  34. ncbi Effect of propionylcarnitine on changes in endothelial function and plasma levels of adhesion molecules induced by acute exercise in patients with intermittent claudication
    Antonio Silvestro
    Department of Clinical Medicine, University of Naples Federico II, Naples, Italy
    Angiology 57:145-54. 2006
    ....
  35. ncbi Adhesion molecules and cardiovascular risk in peripheral arterial disease. Soluble vascular cell adhesion molecule-1 improves risk stratification
    Antonio Silvestro
    Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University Federico II, Naples, Italy
    Thromb Haemost 93:559-63. 2005
    ..308 to 9.573, p=0.013). In conclusion, increased plasma levels of sVCAM-1 have a negative prognostic impact in PAD and improve the predictive value of ABI, which is currently the most powerful risk indicator in these patients...
  36. ncbi The treatment with growth hormone receptor antagonist in acromegaly: effect on vascular structure and function in patients resistant to somatostatin analogues
    M C De Martino
    Departments of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Via S Pansini 5, Naples, Italy
    J Endocrinol Invest 33:663-70. 2010
    ..Acromegaly is known to be associated to vascular damage characterized by an increase of vascular wall thickness and an impairment of vascular function...
  37. ncbi Vitamin C prevents endothelial dysfunction induced by acute exercise in patients with intermittent claudication
    Antonio Silvestro
    Department of Medicine, University of Naples Federico II, Naples, Italy
    Atherosclerosis 165:277-83. 2002
    ..This finding provides a rationale for trials investigating antioxidant therapy and cardiovascular risk in patients with intermittent claudication...
  38. ncbi Aortic valve sclerosis in patients with peripheral and/or coronary arterial disease
    Maria Angela Losi
    Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University School of Medicine, Naples, Italy
    Echocardiography 27:608-12. 2010
    ..There are no data available in patients with peripheral arterial disease (PAD) and with both CAD and PAD...
  39. ncbi Effects of AT1 receptor antagonism with candesartan on endothelial function in patients with hypertension and coronary artery disease
    Pasquale Perrone-Filardi
    Department of Internal Medicine, Cardiovascular and Immunological Sciences, Federico II University, Naples, Italy
    J Clin Hypertens (Greenwich) 11:260-5. 2009
    ..01) but remained unchanged in the placebo group (from 4.49% +/- 1.97% to 5.88% +/- 2.30%; P=ns). AT1 receptor antagonism with candesartan, in addition to b-blocker therapy, improves endothelial function in high-risk hypertensive patients...
  40. ncbi Effects of Ile164 polymorphism of beta2-adrenergic receptor gene on coronary artery disease
    Federico Piscione
    Department of Clinical Medicine, Cardiovascular and Immunology Sciences, Federico II University School of Medicine, Naples, Italy
    J Am Coll Cardiol 52:1381-8. 2008
    ..This study investigated the relationship between beta(2)-adrenergic receptor (B2AR) Ile164 polymorphism and coronary artery disease (CAD)...
  41. doi Leukocyte count in peripheral arterial disease: A simple, reliable, inexpensive approach to cardiovascular risk prediction
    Giuseppe Giugliano
    Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Naples Federico II, Via Pansini 5, 80131 Naples, Italy
    Atherosclerosis 210:288-93. 2010
    ..An elevated leukocyte count is widely proven to predict cardiovascular risk in healthy subjects and coronary patients, but its prognostic role in peripheral arterial disease (PAD) has received scarce attention...
  42. ncbi Relation of brachial artery flow-mediated vasodilation to significant coronary artery disease in patients with peripheral arterial disease
    Pasquale Perrone-Filardi
    Department of Internal Medicine, Cardiovascular and Immunological Sciences, Federico II University and I B B CNR, Naples, Italy
    Am J Cardiol 96:1337-41. 2005
    ..Thus, it may represent a valuable screening test to rule out significant CAD in these patients...
  43. ncbi Inhibition of platelet-activating factor synthesis in human neutrophils and platelets by propionyl-L-carnitine
    M Triggiani
    Division of Clinical Immunology, University of Naples Federico II, Italy
    Biochem Pharmacol 58:1341-8. 1999
    ..This effect of PrC might represent an additional mechanism by which this molecule can exert protective effects in tissue ischemia and in other inflammatory diseases associated with neutrophil and platelet activation...
  44. ncbi Muscle carnitine deficiency in patients with severe peripheral vascular disease
    G Brevetti
    Department of Medicine, University of Naples Federico II, Italy
    Circulation 84:1490-5. 1991
    ..Furthermore, the feasibility of restoring carnitine homeostasis with L-propionylcarnitine provides the basis for clinical trials aimed at assessing the efficacy of this carnitine ester in the treatment of peripheral vascular disease...
  45. ncbi Chronic aortic dissection: still a challenge
    Giuseppe Giugliano
    Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Naples Federico II, Naples, Italy
    Acta Cardiol 64:653-63. 2009
    ..In this regard, serial imaging of the aorta is crucial to detect unstable lesions requiring surgery or an endovascular intervention. As endograft technologies improve endovascular approach may become the future standard of care...
  46. ncbi Relationship between brachial artery flow-mediated dilation and coronary flow reserve in patients with peripheral artery disease
    Teresa Pellegrino
    Department of Biomorphological and Functional Sciences, University Federico II, Napoli, Italy
    J Nucl Med 46:1997-2002. 2005
    ..The aim of this study was to assess the relationship between brachial artery flow-mediated dilation (FMD) and coronary flow reserve (CFR) in patients with peripheral artery disease (PAD)...
  47. ncbi Carotid artery disease and stroke in patients with peripheral arterial disease. The role of inflammation
    Giusy Sirico
    Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Naples Federico II
    Monaldi Arch Chest Dis 72:10-7. 2009
    ..The greater prevalence of hypoechoic unstable carotid plaques could explain why peripheral arterial disease portends higher risk of stroke than coronary artery disease...