Research Topics
Species | G BrevettiSummaryAffiliation: Federico II University Country: Italy Publications
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Publications
Concomitant coronary and peripheral arterial disease: relationship between the inflammatory status of the affected limb and the severity of coronary artery diseaseGregorio Brevetti
Department of Clinical Medicine, Cardiovascular, and Immunological Sciences, University of Naples Federico II, Naples, Italy
J Vasc Surg 49:1465-71. 2009..We investigated the relationship between the inflammatory status in the affected limb and CAD severity...
Cellular adhesion molecules and peripheral arterial diseaseGregorio Brevetti
Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University Federico II, Napoli, Italy
Vasc Med 11:39-47. 2006....- Metabolic syndrome in peripheral arterial disease: relationship with severity of peripheral circulatory insufficiency, inflammatory status, and cardiovascular comorbidityGregorio Brevetti
Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Naples Federico II, Naples, Italy
J Vasc Surg 44:101-7; discussion 107. 2006..In patients with peripheral arterial disease (PAD), we investigated the prevalence of metabolic syndrome and its relationship with the severity of peripheral circulatory insufficiency, inflammatory status, and cardiovascular comorbidity... - Peripheral arterial disease and cardiovascular risk in Italy. Results of the Peripheral Arteriopathy and Cardiovascular Events (PACE) studyGregorio Brevetti
Department of Clinical Medicine and Cardiovascular and Immunological Sciences, Federico II University of Naples, Italy
J Cardiovasc Med (Hagerstown) 7:608-13. 2006..This study was aimed at defining mortality and cardiovascular morbidity of PAD patients in Italy... - Metabolic syndrome and cardiovascular risk prediction in peripheral arterial diseaseG Brevetti
Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Naples Federico II, Italy
Nutr Metab Cardiovasc Dis 20:676-82. 2010..Metabolic syndrome (MetS) was reported to be associated with increased cardiovascular risk in various settings, however its prognostic impact in peripheral arterial disease (PAD) is scanty... 
Mortality in peripheral arterial disease: a comparison of patients managed by vascular specialists and general practitionersGregorio Brevetti
Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Napoli Federico II, Naples, Italy
J Gen Intern Med 22:639-44. 2007..Peripheral arterial disease (PAD) is undertreated by general practitioners (GPs). However, the impact of the suboptimal clinical management is unknown...- [Intermittent claudication in Italy. The Peripheral Arteriopathy and Cardiovascular Events (PACE) study]Gregorio Brevetti
Dipartimento di Medicina Clinica, Scienze Cardiovascolari e Immunologiche, Universita degli Studi Federico II, Napoli
G Ital Cardiol (Rome) 8:34-42. 2007.... - [Infrarenal abdominal aortic aneurysms]Gregorio Brevetti
Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Universita degli Studi Federico II, Napoli
G Ital Cardiol (Rome) 8:543-51. 2007..Symptomatic aneurysms present with back, abdominal, or leg pain and require urgent surgical attention. Rupture of an AAA involves complete loss of aortic wall integrity and is a surgical emergency requiring immediate repair... - Endothelial dysfunction: a key to the pathophysiology and natural history of peripheral arterial disease?Gregorio Brevetti
Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Naples Federico II, Via G Iannelli 45 A, 80131 Napoli, Italy
Atherosclerosis 197:1-11. 2008..Large clinical trials are needed to verify whether affected individuals with depressed endothelial function benefit from specific treatments... - The prevalence of hypoechoic carotid plaques is greater in peripheral than in coronary artery disease and is related to the neutrophil countGregorio Brevetti
Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Napoli Federico II, Napoli, Italy
J Vasc Surg 47:523-9. 2008..To date, no study has compared these two populations with respect to plaque echogenicity, which is an independent risk factor for cerebrovascular events... - Women and peripheral arterial disease: same disease, different issuesGregorio Brevetti
Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Naples Federico II, Naples, Italy
J Cardiovasc Med (Hagerstown) 9:382-8. 2008..The present study aimed to examine sex differences in peripheral arterial disease (PAD) and its clinical correlates... - In concomitant coronary and peripheral arterial disease, inflammation of the affected limbs predicts coronary artery endothelial dysfunctionGregorio Brevetti
Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Naples Federico II, Naples, Italy
Atherosclerosis 201:440-6. 2008..We investigated whether the inflammatory status of affected limbs impairs coronary artery endothelial function (CAEF)... - IGF system and peripheral arterial disease: relationship with disease severity and inflammatory status of the affected limbGregorio Brevetti
Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Naples Federico II, Naples, Italy
Clin Endocrinol (Oxf) 69:894-900. 2008..IGF-1 and its binding proteins are involved in the pathogenesis of atherosclerosis. We designed this study to unravel the relationship of the IGF system with peripheral arterial disease (PAD)... - The impact of comorbidity burden on the cardiovascular risk in the Peripheral Arteriopathy and Cardiovascular Events studyG Brevetti
Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Naples Federico II, Naples, Italy
QJM 101:575-82. 2008..A comprehensive evaluation of comorbidity is important in predicting outcome of patients affected by a chronic disease because of the role of competing risk... - Prevalence of hypoechoic carotid plaques in coronary artery disease: relationship with coexistent peripheral arterial disease and leukocyte numberGregorio Brevetti
Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Naples Federico II, Naples, Italy
Vasc Med 14:13-9. 2009..Thus, our data suggest that in CAD+PAD, evaluation of carotid plaque echogenicity could contribute to improve clinical decision-making and differentiate treatments for individual patients... - Myeloperoxidase, but not C-reactive protein, predicts cardiovascular risk in peripheral arterial diseaseGregorio Brevetti
Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Naples Federico II, Via Pansini 5, Naples, Italy
Eur Heart J 29:224-30. 2008..Accordingly, in these patients we investigated the impact of myeloperoxidase (MPOx) and C-reactive protein on the incidence of myocardial infarction and stroke... - [A new questionnaire for assessing the quality of life of patients with intermittent claudication]A Silvestro
Dipartimento di Medicina Clinica e Scienze Cardiovascolari ed Immunologiche, Universita degli Studi Federico II, Napoli
Minerva Cardioangiol 48:455-65. 2000..At present, however, no generic scale fits all criteria for the ideal quality of life measuring in intermittent claudication... - High levels of adhesion molecules are associated with impaired endothelium-dependent vasodilation in patients with peripheral arterial diseaseG Brevetti
Department of Medicine, University Federico II, Napoli, Italy
Thromb Haemost 85:63-6. 2001.... - European multicenter study on propionyl-L-carnitine in intermittent claudicationG Brevetti
Department of Medicine, University Federico II, Napoli, Italy
J Am Coll Cardiol 34:1618-24. 1999..This study was performed to identify a target population of claudicants for propionyl-L-carnitine treatment... - Exercise increases soluble adhesion molecules ICAM-1 and VCAM-1 in patients with intermittent claudicationG Brevetti
Department of Medicine, University FedericoII, Naples, Italy
Clin Hemorheol Microcirc 24:193-9. 2001..These findings indicate that, in claudicants, exercise is associated with increase in plasma levels of sICAM-1 and sVCAM-1... - Increased inflammatory status and higher prevalence of three-vessel coronary artery disease in patients with concomitant coronary and peripheral atherosclerosisGregorio Brevetti
Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University Federico II, Naples, Italy
Thromb Haemost 89:1058-63. 2003..These results could help to explain the high cardiovascular risk of patients with concomitant CAD and PAD and suggest that PAD be included among the variables used to identify CAD patients for further diagnostic evaluation... - Intermittent claudication: pharmacoeconomic and quality-of-life aspects of treatmentGregorio Brevetti
Department of Medicine, University Federico II, Naples, Italy
Pharmacoeconomics 20:169-81. 2002.... - Early vascular alterations in acromegalyGregorio Brevetti
Department of Medicine, University Federico II, Via G Iannelli 45 A, 80131 Naples, Italy
J Clin Endocrinol Metab 87:3174-9. 2002..No difference in IMT was observed between active and cured patients. In conclusion, patients with acromegaly have functional and morphological vascular alteration that seems, at least in part, dependent on the GH excess itself... - Microcirculation and tissue metabolism in peripheral arterial diseaseG Brevetti
Department of Medicine, University Federico II, Naples, Italy
Clin Hemorheol Microcirc 21:245-54. 1999.... - Endothelial dysfunction in peripheral arterial disease is related to increase in plasma markers of inflammation and severity of peripheral circulatory impairment but not to classic risk factors and atherosclerotic burdenGregorio Brevetti
Department of Clinical Medicine, University Federico II, Via G Iannelli 45 A, 80131 Naples, Italy
J Vasc Surg 38:374-9. 2003.... - Endothelial dysfunction and cardiovascular risk prediction in peripheral arterial disease: additive value of flow-mediated dilation to ankle-brachial pressure indexGregorio Brevetti
Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University Federico II, Naples, Italy
Circulation 108:2093-8. 2003..The study was specially aimed at assessing whether brachial artery flow-mediated dilation (FMD) added to the predictive value of ankle-brachial pressure index (ABPI)... - Prevalence, risk factors and cardiovascular comorbidity of symptomatic peripheral arterial disease in ItalyGregorio Brevetti
Departments of Clinical Medicine and Cardiovascular and Immunological Sciences, Via G Iannelli 45 A, Naples 80313, Italy
Atherosclerosis 175:131-8. 2004..Thus, there is need to alert general practitioners to this topic... - Peripheral arterial disease: the magnitude of the problem and its socioeconomic impactGregorio Brevetti
Department of Medicine and Cardiovascular and Immunological Sciences, University Federico II, Napoli, Italy
Curr Drug Targets Cardiovasc Haematol Disord 4:199-208. 2004..e. those related to lost productivity, and reduced quality of life, respectively) could be reduced if the condition were to be recognized and correctly treated at an early stage... - Relationship between insulin-like growth factor-1 system and exercise tolerance in patients with intermittent claudicationE Laurenzano
Department of Clinical Medicine, University of Naples Federico II, Naples, Italy
Int Angiol 28:202-8. 2009..We aimed the present study at assessing whether IGF-1 system and its changes with exercise are related to walking capacity in intermittent claudication (IC)... - Inflammatory status and endothelial function in asymptomatic and symptomatic peripheral arterial diseaseAntonio Silvestro
Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University Federico II, Naples Italy
Vasc Med 8:225-32. 2003..05). Thus, in PAD, endothelial function and inflammatory status are related to the severity of the circulatory impairment. This finding may contribute to the explanation of the increasingly poor prognosis with increased PAD severity... - Omega-3 polyunsaturated fatty acid in peripheral arterial disease: effect on lipid pattern, disease severity, inflammation profile, and endothelial functionVittorio Schiano
Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Naples Federico II, Naples, Italy
Clin Nutr 27:241-7. 2008..Accordingly, we investigated the effects of omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation on endothelial function and inflammatory status in affected individuals... - The prognostic impact of general and abdominal obesity in peripheral arterial diseaseG Giugliano
Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Naples Federico II, Naples, Italy
Int J Obes (Lond) 34:280-6. 2010..Accordingly, we assessed the impact of body mass index (BMI) and waist circumference (WC) on cardiovascular risk in a homogeneous cohort of PAD patients... - Functional status measured by walking impairment questionnaire and cardiovascular risk prediction in peripheral arterial disease: results of the Peripheral Arteriopathy and Cardiovascular Events (PACE) studyVittorio Schiano
Department of Clinical Medicine, University of Naples Federico II, Naples, Italy
Vasc Med 11:147-54. 2006..26, p = 0.019). In intermittent claudication, a worse functional status entails a greater risk of ischemic events versus low functional impairment... - Effect of propionylcarnitine on changes in endothelial function and plasma levels of adhesion molecules induced by acute exercise in patients with intermittent claudicationAntonio Silvestro
Department of Clinical Medicine, University of Naples Federico II, Naples, Italy
Angiology 57:145-54. 2006.... - Adhesion molecules and cardiovascular risk in peripheral arterial disease. Soluble vascular cell adhesion molecule-1 improves risk stratificationAntonio Silvestro
Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University Federico II, Naples, Italy
Thromb Haemost 93:559-63. 2005..308 to 9.573, p=0.013). In conclusion, increased plasma levels of sVCAM-1 have a negative prognostic impact in PAD and improve the predictive value of ABI, which is currently the most powerful risk indicator in these patients... - The treatment with growth hormone receptor antagonist in acromegaly: effect on vascular structure and function in patients resistant to somatostatin analoguesM C De Martino
Departments of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Via S Pansini 5, Naples, Italy
J Endocrinol Invest 33:663-70. 2010..Acromegaly is known to be associated to vascular damage characterized by an increase of vascular wall thickness and an impairment of vascular function... - Vitamin C prevents endothelial dysfunction induced by acute exercise in patients with intermittent claudicationAntonio Silvestro
Department of Medicine, University of Naples Federico II, Naples, Italy
Atherosclerosis 165:277-83. 2002..This finding provides a rationale for trials investigating antioxidant therapy and cardiovascular risk in patients with intermittent claudication... - Aortic valve sclerosis in patients with peripheral and/or coronary arterial diseaseMaria Angela Losi
Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University School of Medicine, Naples, Italy
Echocardiography 27:608-12. 2010..There are no data available in patients with peripheral arterial disease (PAD) and with both CAD and PAD... - Effects of AT1 receptor antagonism with candesartan on endothelial function in patients with hypertension and coronary artery diseasePasquale Perrone-Filardi
Department of Internal Medicine, Cardiovascular and Immunological Sciences, Federico II University, Naples, Italy
J Clin Hypertens (Greenwich) 11:260-5. 2009..01) but remained unchanged in the placebo group (from 4.49% +/- 1.97% to 5.88% +/- 2.30%; P=ns). AT1 receptor antagonism with candesartan, in addition to b-blocker therapy, improves endothelial function in high-risk hypertensive patients... - Effects of Ile164 polymorphism of beta2-adrenergic receptor gene on coronary artery diseaseFederico Piscione
Department of Clinical Medicine, Cardiovascular and Immunology Sciences, Federico II University School of Medicine, Naples, Italy
J Am Coll Cardiol 52:1381-8. 2008..This study investigated the relationship between beta(2)-adrenergic receptor (B2AR) Ile164 polymorphism and coronary artery disease (CAD)... - Leukocyte count in peripheral arterial disease: A simple, reliable, inexpensive approach to cardiovascular risk predictionGiuseppe Giugliano
Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Naples Federico II, Via Pansini 5, 80131 Naples, Italy
Atherosclerosis 210:288-93. 2010..An elevated leukocyte count is widely proven to predict cardiovascular risk in healthy subjects and coronary patients, but its prognostic role in peripheral arterial disease (PAD) has received scarce attention... - Relation of brachial artery flow-mediated vasodilation to significant coronary artery disease in patients with peripheral arterial diseasePasquale Perrone-Filardi
Department of Internal Medicine, Cardiovascular and Immunological Sciences, Federico II University and I B B CNR, Naples, Italy
Am J Cardiol 96:1337-41. 2005..Thus, it may represent a valuable screening test to rule out significant CAD in these patients... - Inhibition of platelet-activating factor synthesis in human neutrophils and platelets by propionyl-L-carnitineM Triggiani
Division of Clinical Immunology, University of Naples Federico II, Italy
Biochem Pharmacol 58:1341-8. 1999..This effect of PrC might represent an additional mechanism by which this molecule can exert protective effects in tissue ischemia and in other inflammatory diseases associated with neutrophil and platelet activation... - Muscle carnitine deficiency in patients with severe peripheral vascular diseaseG Brevetti
Department of Medicine, University of Naples Federico II, Italy
Circulation 84:1490-5. 1991..Furthermore, the feasibility of restoring carnitine homeostasis with L-propionylcarnitine provides the basis for clinical trials aimed at assessing the efficacy of this carnitine ester in the treatment of peripheral vascular disease... - Chronic aortic dissection: still a challengeGiuseppe Giugliano
Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Naples Federico II, Naples, Italy
Acta Cardiol 64:653-63. 2009..In this regard, serial imaging of the aorta is crucial to detect unstable lesions requiring surgery or an endovascular intervention. As endograft technologies improve endovascular approach may become the future standard of care... - Relationship between brachial artery flow-mediated dilation and coronary flow reserve in patients with peripheral artery diseaseTeresa Pellegrino
Department of Biomorphological and Functional Sciences, University Federico II, Napoli, Italy
J Nucl Med 46:1997-2002. 2005..56, P<0.005). CONCLUSION: Estimated CFR is significantly lower in patients with PAD than in control subjects, and CFR impairment correlates with the degree of peripheral endothelial dysfunction... - Carotid artery disease and stroke in patients with peripheral arterial disease. The role of inflammationGiusy Sirico
Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Naples Federico II
Monaldi Arch Chest Dis 72:10-7. 2009..The greater prevalence of hypoechoic unstable carotid plaques could explain why peripheral arterial disease portends higher risk of stroke than coronary artery disease...