Giuseppe Borzacchiello

Summary

Affiliation: Federico II University
Country: Italy

Publications

  1. ncbi request reprint Presence of bovine papillomavirus type 2 DNA and expression of the viral oncoprotein E5 in naturally occurring urinary bladder tumours in cows
    Giuseppe Borzacchiello
    Department of Pathology and Animal Health, Faculty of Veterinary medicine FEDERICO II Naples University, Via F Delpino, 1 80137 Naples, Italy
    J Gen Virol 84:2921-6. 2003
  2. pmc BAG3 protects Bovine Papillomavirus type 1-transformed equine fibroblasts against pro-death signals
    Roberta Cotugno
    Department of Pharmacy, University of Salerno, Via Giovanni Paolo II n, 132, 84084, Fisciano, Salerno, Italy
    Vet Res 44:61. 2013
  3. pmc Bovine papillomavirus E5 and E7 oncoproteins in naturally occurring tumors: are two better than one?
    Annunziata Corteggio
    Department of Pathology and Animal Health, University of Naples Federico II, Via Veterinaria, Napoli 1 80137, Italy
    Infect Agent Cancer 8:1. 2013
  4. ncbi request reprint Immunohistochemical expression of cyclooxygenase-2 in canine ovarian carcinomas
    G Borzacchiello
    Department of Pathology and Animal Health, General Pathology and Anatomic Pathology Division, Faculty of Veterinary Medicine, University of Naples Federico II Via F Delpino, 1 80137 Naples, Italy
    J Vet Med A Physiol Pathol Clin Med 54:247-9. 2007
  5. doi request reprint Co-expression of bovine papillomavirus E5 and E7 oncoproteins in naturally occurring carcinomas of the urinary bladder in cattle
    G Borzacchiello
    Department of Pathology and Animal Health, Faculty of Veterinary Medicine, Naples University Federico II, Naples, Italy
    J Comp Pathol 141:84-8. 2009
  6. doi request reprint Bovine papillomaviruses, papillomas and cancer in cattle
    Giuseppe Borzacchiello
    Department of Pathology and Animal Health, Faculty of Veterinary Medicine, Naples University Federico II, Via F Delpino, 1 80137, Naples, Italy
    Vet Res 39:45. 2008
  7. doi request reprint Activated platelet-derived growth factor beta receptor expression, PI3K-AKT pathway molecular analysis, and transforming signals in equine sarcoids
    G Borzacchiello
    Department of Pathology and Animal Health, Faculty of Veterinary Medicine, University of Naples Federico II, Via F Delpino, 1 80137, Naples, Italy
    Vet Pathol 46:589-97. 2009
  8. doi request reprint Expression of endothelin-1 and endothelin receptor a in canine ovarian tumours
    G Borzacchiello
    Department of Pathology and Animal Health, General Pathology and Anatomic Pathology Division, Naples, Italy
    Reprod Domest Anim 45:e465-8. 2010
  9. ncbi request reprint Bovine papillomavirus type-2 DNA and expression of E5 and E7 oncoproteins in vascular tumours of the urinary bladder in cattle
    Giuseppe Borzacchiello
    Department of Pathology and Animal Health, University of Naples Federico II, Via F Delpino, 1, 80137, Naples, Italy
    Cancer Lett 250:82-91. 2007
  10. doi request reprint Expression of platelet-derived growth factor-beta receptor and bovine papillomavirus E5 and E7 oncoproteins in equine sarcoid
    G Borzacchiello
    Department of Pathology and Animal Health, Faculty of Veterinary Medicine, Naples University Federico II, Via F Delpino 1, 80137 Naples
    J Comp Pathol 139:231-7. 2008

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Presence of bovine papillomavirus type 2 DNA and expression of the viral oncoprotein E5 in naturally occurring urinary bladder tumours in cows
    Giuseppe Borzacchiello
    Department of Pathology and Animal Health, Faculty of Veterinary medicine FEDERICO II Naples University, Via F Delpino, 1 80137 Naples, Italy
    J Gen Virol 84:2921-6. 2003
    ..Taken together, these data on naturally occurring bovine bladder tumours corroborate the hypothesis of their virus origin...
  2. pmc BAG3 protects Bovine Papillomavirus type 1-transformed equine fibroblasts against pro-death signals
    Roberta Cotugno
    Department of Pharmacy, University of Salerno, Via Giovanni Paolo II n, 132, 84084, Fisciano, Salerno, Italy
    Vet Res 44:61. 2013
    ..Derm cells, an equine BPV-negative fibroblast cell line taken as a normal counterpart. Altogether our findings might suggest a mutual cooperation between BAG3 and viral oncoproteins to sustain cell survival. ..
  3. pmc Bovine papillomavirus E5 and E7 oncoproteins in naturally occurring tumors: are two better than one?
    Annunziata Corteggio
    Department of Pathology and Animal Health, University of Naples Federico II, Via Veterinaria, Napoli 1 80137, Italy
    Infect Agent Cancer 8:1. 2013
    ..Studies on the role of BPV E5 and E7 oncoproteins in naturally occurring tumours are of scientific value, as they may shed new light on the biological role of these two oncogenes in cell transformation...
  4. ncbi request reprint Immunohistochemical expression of cyclooxygenase-2 in canine ovarian carcinomas
    G Borzacchiello
    Department of Pathology and Animal Health, General Pathology and Anatomic Pathology Division, Faculty of Veterinary Medicine, University of Naples Federico II Via F Delpino, 1 80137 Naples, Italy
    J Vet Med A Physiol Pathol Clin Med 54:247-9. 2007
    ..Our results show that COX-2 is expressed in canine ovarian carcinoma, suggesting a potential role of COX-2 in canine ovarian carcinogenesis...
  5. doi request reprint Co-expression of bovine papillomavirus E5 and E7 oncoproteins in naturally occurring carcinomas of the urinary bladder in cattle
    G Borzacchiello
    Department of Pathology and Animal Health, Faculty of Veterinary Medicine, Naples University Federico II, Naples, Italy
    J Comp Pathol 141:84-8. 2009
    ..This is the first report of co-expression of these two oncoproteins in bovine urinary bladder carcinomas. The results suggest that the E7 oncogene has a role in urothelial carcinogenesis...
  6. doi request reprint Bovine papillomaviruses, papillomas and cancer in cattle
    Giuseppe Borzacchiello
    Department of Pathology and Animal Health, Faculty of Veterinary Medicine, Naples University Federico II, Via F Delpino, 1 80137, Naples, Italy
    Vet Res 39:45. 2008
    ....
  7. doi request reprint Activated platelet-derived growth factor beta receptor expression, PI3K-AKT pathway molecular analysis, and transforming signals in equine sarcoids
    G Borzacchiello
    Department of Pathology and Animal Health, Faculty of Veterinary Medicine, University of Naples Federico II, Via F Delpino, 1 80137, Naples, Italy
    Vet Pathol 46:589-97. 2009
    ..Our results provide new insights into the pathogenesis of equine sarcoids and support the validity of this in-vivo model to further characterize the molecular pathways underlying BPV E5-induced carcinogenesis...
  8. doi request reprint Expression of endothelin-1 and endothelin receptor a in canine ovarian tumours
    G Borzacchiello
    Department of Pathology and Animal Health, General Pathology and Anatomic Pathology Division, Naples, Italy
    Reprod Domest Anim 45:e465-8. 2010
    ..Our results show that ET-1 and ET-A are overexpressed in canine ovarian tumours, suggesting a potential role of these two molecules in canine ovarian carcinogenesis...
  9. ncbi request reprint Bovine papillomavirus type-2 DNA and expression of E5 and E7 oncoproteins in vascular tumours of the urinary bladder in cattle
    Giuseppe Borzacchiello
    Department of Pathology and Animal Health, University of Naples Federico II, Via F Delpino, 1, 80137, Naples, Italy
    Cancer Lett 250:82-91. 2007
    ..Furthermore, the expression of the two viral oncoproteins confirm that the virus may have a causative role in the neoplastic process...
  10. doi request reprint Expression of platelet-derived growth factor-beta receptor and bovine papillomavirus E5 and E7 oncoproteins in equine sarcoid
    G Borzacchiello
    Department of Pathology and Animal Health, Faculty of Veterinary Medicine, Naples University Federico II, Via F Delpino 1, 80137 Naples
    J Comp Pathol 139:231-7. 2008
    ..These findings add further weight to the theory that BPV and the PDGF-betaR may have a role in the pathogenesis of this disease...
  11. ncbi request reprint Bovine papillomavirus E5 oncoprotein binds to the activated form of the platelet-derived growth factor beta receptor in naturally occurring bovine urinary bladder tumours
    G Borzacchiello
    Department of Pathology and Animal Health, Faculty of Veterinary Medicine, Naples University Federico II, Naples, Italy
    Oncogene 25:1251-60. 2006
    ..Successful bladder tumour regression would provide a valuable model for therapeutic vaccination against papillomavirus-associated tumours...
  12. pmc O(6)-methylguanine-DNA methyltransferase in equine sarcoids: molecular and epigenetic analysis
    Gennaro Altamura
    Department of Pathology and Animal Health, University of Naples Federico II, Via Veterinaria, 1 80137, Napoli, Italy
    BMC Vet Res 8:218. 2012
    ..The expression of the oncosuppressor protein was assessed in normal and sarcoid cells and tissues. In addition, the DNA methylation profile was analysed to assess the role of epigenetic mechanism in regulation of MGMT expression...
  13. doi request reprint Bacterial isolates from the urine of cattle affected by urothelial tumors of the urinary bladder
    Sante Roperto
    Department of Pathology and Animal Health, Division of Infectious Diseases, Faculty of Veterinary Medicine, University of Naples Federico II, Via Delpino, 1 80137 Naples, Italy
    Res Vet Sci 93:1361-6. 2012
    ..As in man, therefore, bacteria could play both a direct and an indirect role in bovine bladder carcinogenesis...
  14. doi request reprint Detection of bovine papillomavirus type 2 in the peripheral blood of cattle with urinary bladder tumours: possible biological role
    Sante Roperto
    Department of Pathology and Animal Health, Faculty of Veterinary Medicine, Naples University Federico II, Naples, Italy
    J Gen Virol 89:3027-33. 2008
    ....
  15. pmc Molecular and epigenetic analysis of the fragile histidine triad tumour suppressor gene in equine sarcoids
    Maria Strazzullo
    Department of Pathology and Animal Health, University of Naples Federico II, Via Veterinaria, Naples, Italy
    BMC Vet Res 8:30. 2012
    ..The expression of the oncosuppressor protein was assessed in normal and sarcoid cells and tissue...
  16. pmc Productive infection of bovine papillomavirus type 2 in the placenta of pregnant cows affected with urinary bladder tumors
    Sante Roperto
    Department of Pathology and Animal Health, Naples University Federico II, Naples, Italy
    PLoS ONE 7:e33569. 2012
    ..Electron microscopic investigations detected viral particles in nuclei of uterine and chorionic epithelium. This study shows that both active and productive infections by BPV-2 in the placenta of pregnant cows can occur in vivo...
  17. pmc Bovine papillomavirus type 2 infection and a series of mesenchymal tumors of the urinary bladder in cattle
    Manuela Martano
    Department of Veterinary Medicine and Animal Productions, Naples University Federico II, Naples, Italy
    Biomed Res Int 2013:814635. 2013
    ..Furthermore, these findings demonstrate that BPV-2 infects both epithelial and mesenchymal cells. ..
  18. doi request reprint Bovine papillomavirus E7 oncoprotein binds to p600 in naturally occurring equine sarcoids
    Annunziata Corteggio
    Department of Pathology and Animal Health, Faculty of Veterinary Medicine, University of Naples Federico II, Via Veterinaria 1, 80137 Naples, Italy
    J Gen Virol 92:378-82. 2011
    ..Finally, the system provides a suitable animal model of papillomavirus-associated cancer to test therapeutic vaccination against E7...
  19. pmc Papillomavirus E5: the smallest oncoprotein with many functions
    Aldo Venuti
    Department of Pathology and Animal Health, University of Naples Federico II, Naples, Italy
    Mol Cancer 10:140. 2011
    ..This review will highlight the differences between HPV-16 E5 (16E5) and E5 from other PVs, primarily from BPV. It will discuss the targeting of E5 as a possible therapeutic agent...
  20. doi request reprint Activated platelet-derived growth factor β receptor and Ras-mitogen-activated protein kinase pathway in natural bovine urinary bladder carcinomas
    Annunziata Corteggio
    Department of Pathology and Animal Health, Faculty of Veterinary Medicine, University of Naples Federico II, Via F Delpino, 1, 80137 Napoli, Italy
    Vet J 191:393-5. 2012
    ....
  21. pmc Bovine papillomavirus type 2 infection and microscopic patterns of urothelial tumors of the urinary bladder in water buffaloes
    Paola Maiolino
    Department of Veterinary Medicine and Animal Productions, Naples University Federico II, Via Delpino 1, 80137 Naples, Italy
    Biomed Res Int 2013:937918. 2013
    ..Morphological and molecular findings show that BPV-2 infection contributes to the development of urothelial bladder carcinogenesis also in water buffaloes...
  22. pmc Expression of heat shock proteins in premalignant and malignant urothelial lesions of bovine urinary bladder
    Mariarita Romanucci
    Department of Comparative Biomedical Sciences, Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy
    Cell Stress Chaperones 17:683-92. 2012
    ....
  23. pmc Calpain3 is expressed in a proteolitically active form in papillomavirus-associated urothelial tumors of the urinary bladder in cattle
    Sante Roperto
    Department of Pathology and Animal Health, Division of Infectious Diseases, Naples University Federico II, Naples, Italy
    PLoS ONE 5:e10299. 2010
    ..So far the link between calpain3 and tumors comes from in vitro studies. The objective of this study was to describe Capn3 activation in naturally occurring urothelial tumors of the urinary bladder in cattle...
  24. ncbi request reprint Expression of beta-catenin, E-cadherin and APC in canine mammary tumors
    Brunella Restucci
    Departments of Pathology and Animal Health, Faculty of Veterinary Medicine, University Federico II, Naples, Italy
    Anticancer Res 27:3083-9. 2007
    ..Recently, a pathway named Wnt-1, involving beta-catenin and APC protein, has emerged as an important player in many human tumor types, including mammary neoplasms...
  25. doi request reprint 1st International Workshop on Papillomavirus E5 Oncogene-a report
    Giuseppe Borzacchiello
    Department of Pathology and Animal Health, Faculty of Veterinary Medicine, University of Naples Federico II, Naples, Italy
    Virology 408:135-7. 2010
    ..The 1st International Workshop on Papillomavirus E5 Oncogene was held in Capri, Italy, 27-28 May 2010. Here we present a brief report of the various lectures which addressed the multiple facets of the E5 protein...
  26. pmc Analysis of Activated Platelet-Derived Growth Factor β Receptor and Ras-MAP Kinase Pathway in Equine Sarcoid Fibroblasts
    Gennaro Altamura
    Department of Veterinary Medicine and Animal Production, University of Naples Federico II, Via Veterinaria, 180137 Napoli, Italy
    Biomed Res Int 2013:283985. 2013
    ..This study contributes to a better understanding of the molecular mechanisms involved in the pathology of sarcoids and paves the way to a new therapeutic approach for the treatment of this common equine skin neoplasm. ..
  27. doi request reprint PBMCs are additional sites of productive infection of bovine papillomavirus type 2
    Sante Roperto
    Dipartimento di Patologia e Sanita Animale, Universita di Napoli Federico II, Napoli, Italy
    J Gen Virol 92:1787-94. 2011
    ..In light of these observations, the life cycle of PVs needs to be revisited to gain novel insights into the epidemiology of BPV infection and the pathogenesis of related diseases...
  28. ncbi request reprint Expression of Major Histocompatibility Complex class I and II in a case of Neospora caninum myositis in a dog
    O Paciello
    Dipartimento di Patologia e Sanita Animale, Settore di Anatomia Patologica, Facolta di Medicina Veterinaria, Universita di Napoli Federico II, Napoli, Italy
    Acta Myol 23:151-3. 2004
    ..A possible role of these glycoproteins in the pathogenesis of Neospora-associated myositis is discussed...
  29. doi request reprint Multiple glomus tumors of the urinary bladder in a cow associated with bovine papillomavirus type 2 (BPV-2) infection
    S Roperto
    Department of Pathology and Animal Health, Faculty of Veterinary Medicine, Naples University Federico II, Naples, Italy
    Vet Pathol 45:39-42. 2008
    ..Finally, the microscopic pattern of tumor described here shares striking morphologic and immunohistochemical similarities with the angiomatous form of glomus tumor known to occur in man...
  30. doi request reprint Ferritin heavy chain (FHC) is up-regulated in papillomavirus-associated urothelial tumours of the urinary bladder in cattle
    S Roperto
    Department of Veterinary Pathology and Animal Health, Naples University Federico II, Naples, Italy
    J Comp Pathol 142:9-18. 2010
    ..These findings suggest that FHC up-regulation may be mediated by activation of NF-kappaB and that in turn this may be related to the resistance of bovine papillomavirus type-2 (BPV-2) infected urothelial cells to apoptosis...
  31. ncbi request reprint Cyclooxygenase-1 and -2 expression in urothelial carcinomas of the urinary bladder in cows
    G Borzacchiello
    Department of Pathology and Animal Health, General Pathology Division, Faculty of Veterinary Medicine, Federico II University of Naples, Via Veterinaria 1, 80137 Naples, Italy
    Vet Pathol 40:455-9. 2003
    ..Coexpression of both enzyme isoforms was also revealed by confocal laser scanning microscopic investigations. This study indicates that COX-2 is overexpressed in naturally occurring urothelial carcinomas of cows...
  32. ncbi request reprint Bovine papillomavirus type-2 (BPV-2) infection and expression of uroplakin IIIb, a novel urothelial cell marker, in urinary bladder tumors of cows
    S Roperto
    Department of Pathology and Animal Health, Division of General Pathology, Faculty of Veterinary Medicine, Via Delpino 1, 80137 Naples, Italy
    Vet Pathol 42:812-8. 2005
    ..Although UP IIIb expression does not seem to correlate with the biological behavior of urothelial tumors, it appears to be a highly sensitive marker for bovine urothelial tumors...
  33. ncbi request reprint Neurotrophin 3 and its receptor TrkC immunoreactivity in glucagon cells of buffalo pancreas
    C Lucini
    Dip Strutture, Funzioni e Tecnologie Biologiche, Universita di Napoli Federico II, Italy
    Anat Histol Embryol 32:253-6. 2003
    ..By double immunohistochemical staining, NT3- and TrkC-IR resulted to be colocalized in glucagon immunoreactive cells. These findings suggest endocrine and/or autocrine roles of NT3 in pancreatic A cells...
  34. doi request reprint A review of bovine urothelial tumours and tumour-like lesions of the urinary bladder
    S Roperto
    Department of Pathology and Animal Health, Naples University Federico II, Naples, Italy
    J Comp Pathol 142:95-108. 2010
    ..High-grade carcinomas, and low and high-grade invasive tumours, are less commonly seen. Bovine papillomavirus (BPV) infection and ingestion of bracken fern both play a central role in carcinogenesis of these lesions...
  35. doi request reprint Cryopreservation of feline epididymal spermatozoa from dead and alive animals and its use in assisted reproduction
    N Cocchia
    Department of Veterinary Clinic Sciences, University of the Studies of Naples Federico II, Naples, Italy
    Zygote 18:1-8. 2010
    ..0% glycerol in 0.25 ml straws. The procedure used in the present study for epididymal cat sperm cryopreservation may be applied to bank the genetic resources of wild felid species...
  36. ncbi request reprint Sialic acid and GM3 ganglioside expression in papillomavirus-associated urinary bladder tumours of cattle with chronic enzootic haematuria
    S Roperto
    Department of Pathology and Animal Health, Faculty of Veterinary Medicine, Naples University Federico II, Via Delpino 1, 80137 Naples, Itatly
    J Comp Pathol 137:87-93. 2007
    ..GM1, GM2, GD1a, GD3 and FucGM1 were found as minor components. The study suggested that GM3 ganglioside may have a crucial role in "downregulation" of the metastatic potential of bovine urothelial cancers...
  37. ncbi request reprint Expression of peroxisome proliferator-activated receptor gamma (PPAR-gamma) in canine nasal carcinomas
    O Paciello
    Division of Pathology, Department of Pathology and Animal Health, Faculty of Veterinary Medicine, University of Naples Federico II, Via Delpino, 1, 80137 Naples, Italy
    J Vet Med A Physiol Pathol Clin Med 54:406-10. 2007
    ..The importance of this transcription factor in the pathophysiology of several different tumours has stimulated much research in this field and has opened new opportunities for the treatment of the tumours...
  38. ncbi request reprint Bovine papillomavirus type 4 in oesophageal papillomas of cattle from the south of Italy
    G Borzacchiello
    Department of Pathology and Animal Health, General Pathology and Infectious Diseases Division, Faculty of Veterinary Medicine, Naples University Federico II, Rome, Italy
    J Comp Pathol 128:203-6. 2003
    ..Nucleotide sequencing of the PCR amplicons confirmed the presence of BPV-4 in the papillomas. This is the first report of such infections in a European country other than Britain...
  39. ncbi request reprint First report of morphological variants of urothelial carcinoma in the dog
    G Borzacchiello
    Department of Pathology and Animal Health, General Pathology Division, Faculty of Veterinary Medicine, Naples University Federico II, Naples, Italy
    Vet Res Commun 27:327-30. 2003
  40. ncbi request reprint Uroplakin expression in the urothelial tumors of cows
    V Ambrosio
    Department of Pathology and Animal Health, Faculty of Veterinary Medicine, Naples University Federico II, Italy
    Vet Pathol 38:657-60. 2001
    ..Although UP expression is remarkably changed in bladder carcinogenesis of cattle, the UP gene(s) remains expressed during cell transformation and tumor progression...
  41. doi request reprint Bilateral ovarian malignant mixed Mullerian tumor in a dog
    E Antuofermo
    Department of Pathology and Veterinary Clinic, Section of General Pathology and Anatomic Pathology, Faculty of Veterinary Medicine, Sassari University, Via Vienna 2, 07100 Sassari, Italy
    Vet Pathol 46:453-6. 2009
    ..Chondrocytes also expressed S-100 protein. On the basis of similarities to human ovarian MMMT, the diagnosis was heterologous malignant mixed Müllerian tumor of the ovary...
  42. doi request reprint Lymphoepithelioma-like carcinoma of the urinary bladder in a cow associated with bovine papillomavirus type-2
    R Brun
    Department of Pathology and Animal Health, Divisions of General Pathology and Infectious Diseases, Faculty of Veterinary Medicine, Via Delpino 1, Naples University Federico II, Naples, Italy
    J Comp Pathol 139:121-5. 2008
    ..This report extends the spectrum of neoplastic urothelial lesions described in cattle and provides further evidence that some features of these tumours are similar to human counterparts...
  43. doi request reprint Phosphatidylinositol-3-kinase-AKT pathway, phospho-JUN and phospho-JNK expression in spontaneously arising bovine urinary bladder tumours
    A Corteggio
    Division of Anatomic Pathology and General Pathology, Department of Pathology and Animal Health, Faculty of Veterinary Medicine, University of Naples Federico II, Napoli, Italy
    J Comp Pathol 143:173-8. 2010
    ..These findings provide new insights into the aetiopathogenic mechanisms underlying naturally occurring bovine urothelial carcinogenesis and contribute to understanding of the role of E5 oncoprotein in naturally occurring tumorigenesis...
  44. doi request reprint Melanosis of the urinary bladder in a cow
    V Russo
    Department of Pathology and Animal Health, Faculty of Veterinary Medicine, Naples University Federico II, Naples, Italy
    Vet Pathol 45:46-50. 2008
    ..Finally, virologic examination revealed the presence of bovine papillomavirus type 2...