Bernadette Biondi

Summary

Affiliation: Federico II University
Country: Italy

Publications

  1. ncbi request reprint Subclinical hyperthyroidism: clinical features and treatment options
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, 80131 Naples, Italy
    Eur J Endocrinol 152:1-9. 2005
  2. ncbi request reprint Thyroid-hormone therapy and thyroid cancer: a reassessment
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Naples, Italy
    Nat Clin Pract Endocrinol Metab 1:32-40. 2005
  3. doi request reprint Benefits of thyrotropin suppression versus the risks of adverse effects in differentiated thyroid cancer
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Naples, Italy
    Thyroid 20:135-46. 2010
  4. doi request reprint Combination treatment with T4 and T3: toward personalized replacement therapy in hypothyroidism?
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 97:2256-71. 2012
  5. doi request reprint Mechanisms in endocrinology: Heart failure and thyroid dysfunction
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Italy
    Eur J Endocrinol 167:609-18. 2012
  6. doi request reprint How could we improve the increased cardiovascular mortality in patients with overt and subclinical hyperthyroidism?
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    Eur J Endocrinol 167:295-9. 2012
  7. doi request reprint Natural history, diagnosis and management of subclinical thyroid dysfunction
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    Best Pract Res Clin Endocrinol Metab 26:431-46. 2012
  8. ncbi request reprint The clinical significance of subclinical thyroid dysfunction
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    Endocr Rev 29:76-131. 2008
  9. doi request reprint Endothelial-mediated coronary flow reserve in patients with mild thyroid hormone deficiency
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    Eur J Endocrinol 161:323-9. 2009
  10. ncbi request reprint Cardiovascular effects of mild hypothyroidism
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Naples, Italy
    Thyroid 17:625-30. 2007

Detail Information

Publications32

  1. ncbi request reprint Subclinical hyperthyroidism: clinical features and treatment options
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, 80131 Naples, Italy
    Eur J Endocrinol 152:1-9. 2005
    ..Subclinical hyperthyroidism and its related clinical manifestations are reversible and may be prevented by timely treatment...
  2. ncbi request reprint Thyroid-hormone therapy and thyroid cancer: a reassessment
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Naples, Italy
    Nat Clin Pract Endocrinol Metab 1:32-40. 2005
    ..5 mU/l). Only selected patients with high-risk papillary and follicular thyroid cancer require long-term TSH-suppressive doses of L-T(4). In these patients, careful monitoring is necessary to avoid undesirable effects on bone and heart...
  3. doi request reprint Benefits of thyrotropin suppression versus the risks of adverse effects in differentiated thyroid cancer
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Naples, Italy
    Thyroid 20:135-46. 2010
    ....
  4. doi request reprint Combination treatment with T4 and T3: toward personalized replacement therapy in hypothyroidism?
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 97:2256-71. 2012
    ..The aim of this review is to assess the physiological basis and the results of current studies on this topic...
  5. doi request reprint Mechanisms in endocrinology: Heart failure and thyroid dysfunction
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Italy
    Eur J Endocrinol 167:609-18. 2012
    ..The aim of this review article was to assess the results of the prospective studies that evaluated the risk of HF in patients with overt and subclinical thyroid disease and discuss the mechanism of this dysfunction...
  6. doi request reprint How could we improve the increased cardiovascular mortality in patients with overt and subclinical hyperthyroidism?
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    Eur J Endocrinol 167:295-9. 2012
    ..Randomized controlled clinical trials are needed to assess the benefits of treatment to improve the cardiovascular mortality and morbidity of mild and overt hyperthyroidism...
  7. doi request reprint Natural history, diagnosis and management of subclinical thyroid dysfunction
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    Best Pract Res Clin Endocrinol Metab 26:431-46. 2012
    ..Mild SHypo should be treated in infertile and pregnant women...
  8. ncbi request reprint The clinical significance of subclinical thyroid dysfunction
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    Endocr Rev 29:76-131. 2008
    ..Lastly, we address the issue of the need to treat slight thyroid hormone deficiency or excess in relation to the patient's age...
  9. doi request reprint Endothelial-mediated coronary flow reserve in patients with mild thyroid hormone deficiency
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    Eur J Endocrinol 161:323-9. 2009
    ..Although coronary flow reserve (CFR) is reduced in patients with subclinical hypothyroidism (SHypo), the endothelial response of coronary vasomotion has never been explored in this clinical setting...
  10. ncbi request reprint Cardiovascular effects of mild hypothyroidism
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Naples, Italy
    Thyroid 17:625-30. 2007
    ....
  11. ncbi request reprint Effects of subclinical thyroid dysfunction on the heart
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II School of Medicine, 80131 Naples, Italy
    Ann Intern Med 137:904-14. 2002
    ..Mounting evidence indicates that subclinical thyroid dysfunction has important clinical effects and prognostic implications, supporting the view that it is not a compensated biochemical change sensu strictu...
  12. ncbi request reprint Effects of thyroid hormone on the cardiovascular system
    Serafino Fazio
    Department of Clinical Medicine and Cardiovascular Sciences, University of Naples Federico II School of Medicine, 80131, Naples, Italy
    Recent Prog Horm Res 59:31-50. 2004
    ....
  13. ncbi request reprint Cardiovascular safety of acute recombinant human thyrotropin administration to patients monitored for differentiated thyroid cancer
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II School of Medicine, 80131 Naples, Italy
    J Clin Endocrinol Metab 88:211-4. 2003
    ..Our data demonstrate that rhTSH does not alter cardiovascular function acutely. Consequently, it can safely be used in the routine staging of patients affected by differentiated thyroid cancer...
  14. ncbi request reprint Subclinical hypothyroidism and cardiac function
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II School of Medicine, Naples, Italy
    Thyroid 12:505-10. 2002
    ..Therefore, it would seem appropriate to initiate timely treatment of patients with mild thyroid failure to prevent cardiac involvement...
  15. ncbi request reprint Subclinical hypothyroidism and cardiovascular risk: a reason to treat?
    Emiliano A Palmieri
    Department of Clinical Medicine, Cardiovascular and Immunological Science, University Federico II School of Medicine, Naples, Italy
    Treat Endocrinol 3:233-44. 2004
    ....
  16. doi request reprint Impact of resistance to thyroid hormone on the cardiovascular system in adults
    Melania Pulcrano
    Department of Clinical and Molecular Endocrinology and Oncology, University Federico II of Naples, Via S Pansini 5, Naples, Italy
    J Clin Endocrinol Metab 94:2812-6. 2009
    ..The clinical manifestations of resistance to thyroid hormone (RTH) are highly variable, and the impact of RTH on the cardiovascular system has been poorly investigated...
  17. ncbi request reprint Flow cytometry phenotypization of thyroidal lymphoid infiltrate and functional status in Hashimoto's thyroiditis
    Pio Zeppa
    Department of Anatomic Pathology and Cytopathology, Faculty of Medicine and Surgery, Universita di Napoli Federico II, Naples, Italy
    Anal Quant Cytol Histol 28:148-56. 2006
    ..To evaluate the thyroidal lymphoid infiltrate (TLI) in thyroidal functional status (TFS) for differences among patients with Hashimoto's thyroiditis (HT)...
  18. ncbi request reprint Effects of thyroid hormone on cardiac function: the relative importance of heart rate, loading conditions, and myocardial contractility in the regulation of cardiac performance in human hyperthyroidism
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University Federico II School of Medicine, 80131 Naples, Italy
    J Clin Endocrinol Metab 87:968-74. 2002
  19. ncbi request reprint Patients with subclinical Cushing's syndrome due to adrenal adenoma have increased cardiovascular risk
    Libuse Tauchmanova
    Department of Molecular and Clinical Endocrinology and Oncology, University Federico II, Via S Pansini n 5, 801 31 Naples, Italy
    J Clin Endocrinol Metab 87:4872-8. 2002
    ..This finding supports the concept that chronic mild endogenous cortisol excess may have important systemic effects on the human body...
  20. doi request reprint Cardiovascular involvement in patients with different causes of hyperthyroidism
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    Nat Rev Endocrinol 6:431-43. 2010
    ..Consequently, the etiology of hyperthyroidism must be established to enable correct treatment of the disease and the cardiovascular complications...
  21. pmc Adjuvant treatment with thyrotropin alpha for remnant ablation in thyroid cancer
    Bernadette Biondi
    Department of Clinical and Molecular, Endocrinology and Oncology, University of Naples Federico II, Naples, Italy
    Biologics 3:9-13. 2009
    ..More studies are required to establish the amount of radioiodine to be administered especially in high-risk patients...
  22. ncbi request reprint Recombinant human TSH modulates in vivo C-telopeptides of type-1 collagen and bone alkaline phosphatase, but not osteoprotegerin production in postmenopausal women monitored for differentiated thyroid carcinoma
    Gherardo Mazziotti
    Department of Clinical and Experimental Medicine, F Magrassi and A Lanzara, Second University of Naples, Naples, Italy
    J Bone Miner Res 20:480-6. 2005
    ..The inhibitory effect of TSH on bone resorption occurred only in postmenopausal women who showed low BMD and a high bone turnover rate as an effect of L-thyroxine suppressive therapy...
  23. doi request reprint Enhancement of vascular endothelial function by recombinant human thyrotropin
    Raffaele Napoli
    Department of Internal Medicine and Cardiovascular Sciences, University Federico II, Via Pansini 5, Naples, Italy
    J Clin Endocrinol Metab 93:1959-63. 2008
    ..The possibility that TSH also affects the cardiovascular system has been poorly explored. Endothelial cells and vascular smooth muscle cells possess TSH receptors...
  24. ncbi request reprint Hypothyroidism as a risk factor for cardiovascular disease
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II School of Medicine, Via S Pansini 5, 80131, Naples, Italy
    Endocrine 24:1-13. 2004
    ..This constellation of reversible cardiovascular abnormalities in patient with TSH levels <10 mU/L indicate that the benefits of treatment of mild thyroid failure with appropriate doses of L-thyroxine outweigh the risk...
  25. doi request reprint Invited commentary: Cardiovascular mortality in subclinical hyperthyroidism: an ongoing dilemma
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    Eur J Endocrinol 162:587-9. 2010
    ....
  26. ncbi request reprint Should we treat all subjects with subclinical thyroid disease the same way?
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    Eur J Endocrinol 159:343-5. 2008
  27. ncbi request reprint Gender differences in the prevalence, clinical features and response to cabergoline in hyperprolactinemia
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology, Federico II University of Naples, Via S Pansini 5, Italy
    Eur J Endocrinol 148:325-31. 2003
    ..Whether this reflects only a delay in diagnosis in men or a true gender difference in tumor pathogenesis is still unclear...
  28. ncbi request reprint The importance of using strict inclusion criteria in subclinical hypothyroid studies
    Bernadette Biondi
    Am J Med 114:76; author reply 77. 2003
  29. ncbi request reprint Recombinant human thyrotropin reduces serum vascular endothelial growth factor levels in patients monitored for thyroid carcinoma even in the absence of thyroid tissue
    Francesca Sorvillo
    Department of Clinical and Experimental Medicine F Magrassi and A Lanzara, Second University of Naples, Italy
    J Clin Endocrinol Metab 88:4818-22. 2003
    ..This result would suggest that TSH may be able in vivo to regulate VEGF production from tissues other than the thyroid gland...
  30. ncbi request reprint Screening and treatment for subclinical thyroid disease
    Bernadette Biondi
    JAMA 291:1562; author reply 1562-3. 2004
  31. ncbi request reprint Short-term hypothyroidism after Levothyroxine-withdrawal in patients with differentiated thyroid cancer: clinical and quality of life consequences
    Leonidas H Duntas
    Endocrine Unit, Evgenidion Hospital, University of Athens, 20 Papadiamantopoulou St, 11528 Athens, Greece
    Eur J Endocrinol 156:13-9. 2007
    ....
  32. pmc Thyroid B-flow twinkling sign: a new feature of papillary cancer
    Luca Brunese
    Department of Health Science, Chair of Radiology, University of Molise, Campobasso, Italy
    Eur J Endocrinol 159:447-51. 2008
    ..Using B-flow imaging (BFI), we identified a new sign (the twinkling sign; BFI-TS) in 'suspect' PTC nodules, which appeared to be generated by microcalcifications...