M Bifulco

Summary

Affiliation: Federico II University
Country: Italy

Publications

  1. ncbi Targeting the endocannabinoid system in cancer therapy: a call for further research
    Maurizio Bifulco
    Dipartimento di Scienze Farmaceutiche, Universita di Salerno, Fisciano, Salerno, Italy
    Nat Med 8:547-50. 2002
  2. pmc 2',3'-Cyclic nucleotide 3'-phosphodiesterase: a membrane-bound, microtubule-associated protein and membrane anchor for tubulin
    Maurizio Bifulco
    Dipartimento di Scienze Farmaceutiche, Universita di Salerno, 84084 Fisciano, Salerno, Italy
    Proc Natl Acad Sci U S A 99:1807-12. 2002
  3. ncbi Control by the endogenous cannabinoid system of ras oncogene-dependent tumor growth
    M Bifulco
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano, Salerno, Italy
    FASEB J 15:2745-7. 2001
  4. ncbi A new strategy to block tumor growth by inhibiting endocannabinoid inactivation
    Maurizio Bifulco
    Istituto di Endocrinologia ed Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, and Dipartimento di Biologia e Patologia Cellulare e Molecolare L Califano, Universita di Napoli Federico II, Italy
    FASEB J 18:1606-8. 2004
  5. ncbi [The endocannabinoid system as a target for the development of new drugs for cancer therapy]
    Maurizio Bifulco
    Dipartimento di Scienze Farmaceutiche, Universita di Salerno, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita Federico II, Napoli
    Recenti Prog Med 94:194-8. 2003
  6. ncbi Role of the isoprenoid pathway in ras transforming activity, cytoskeleton organization, cell proliferation and apoptosis
    Maurizio Bifulco
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Salerno, via Ponte Don Melillo 84084, Fisciano, Salerno, Italy
    Life Sci 77:1740-9. 2005
  7. pmc Cannabinoids and cancer: pros and cons of an antitumour strategy
    Maurizio Bifulco
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Salerno, Via Ponte Don Melillo, Fisciano 84084, Salerno, Italy
    Br J Pharmacol 148:123-35. 2006
  8. ncbi Endocannabinoids as emerging suppressors of angiogenesis and tumor invasion (review)
    Maurizio Bifulco
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Salerno, 84084 Fisciano SA, Italy
    Oncol Rep 17:813-6. 2007
  9. pmc Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells
    V Di Marzo
    Istituto per la Chimica di Molecole di Interesse Biologico, Via Toiano 6, 80072, Arco Felice, Napoli, Italy
    Biochem J 358:249-55. 2001
  10. ncbi Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation
    D Melck
    Istituto per la Chimica di Molecole di Interesse Biologico, Consiglio Nazionale delle Ricerche, Arco Felice Na, Italy
    Endocrinology 141:118-26. 2000

Collaborators

Detail Information

Publications63

  1. ncbi Targeting the endocannabinoid system in cancer therapy: a call for further research
    Maurizio Bifulco
    Dipartimento di Scienze Farmaceutiche, Universita di Salerno, Fisciano, Salerno, Italy
    Nat Med 8:547-50. 2002
  2. pmc 2',3'-Cyclic nucleotide 3'-phosphodiesterase: a membrane-bound, microtubule-associated protein and membrane anchor for tubulin
    Maurizio Bifulco
    Dipartimento di Scienze Farmaceutiche, Universita di Salerno, 84084 Fisciano, Salerno, Italy
    Proc Natl Acad Sci U S A 99:1807-12. 2002
    ....
  3. ncbi Control by the endogenous cannabinoid system of ras oncogene-dependent tumor growth
    M Bifulco
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano, Salerno, Italy
    FASEB J 15:2745-7. 2001
    ....
  4. ncbi A new strategy to block tumor growth by inhibiting endocannabinoid inactivation
    Maurizio Bifulco
    Istituto di Endocrinologia ed Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, and Dipartimento di Biologia e Patologia Cellulare e Molecolare L Califano, Universita di Napoli Federico II, Italy
    FASEB J 18:1606-8. 2004
    ....
  5. ncbi [The endocannabinoid system as a target for the development of new drugs for cancer therapy]
    Maurizio Bifulco
    Dipartimento di Scienze Farmaceutiche, Universita di Salerno, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita Federico II, Napoli
    Recenti Prog Med 94:194-8. 2003
    ..This evidence is reviewed here and suggests that future anti-cancer therapy might be developed from our knowledge of how the endocannabinoid system controls the growth and metastasis of malignant cells...
  6. ncbi Role of the isoprenoid pathway in ras transforming activity, cytoskeleton organization, cell proliferation and apoptosis
    Maurizio Bifulco
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Salerno, via Ponte Don Melillo 84084, Fisciano, Salerno, Italy
    Life Sci 77:1740-9. 2005
    ....
  7. pmc Cannabinoids and cancer: pros and cons of an antitumour strategy
    Maurizio Bifulco
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Salerno, Via Ponte Don Melillo, Fisciano 84084, Salerno, Italy
    Br J Pharmacol 148:123-35. 2006
    ..In this article, we will review the principal molecular pathways modulated by cannabinoids on cancer and summarize pros and cons evidence on the possible future use of endocannabinoid-based drugs in cancer therapy...
  8. ncbi Endocannabinoids as emerging suppressors of angiogenesis and tumor invasion (review)
    Maurizio Bifulco
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Salerno, 84084 Fisciano SA, Italy
    Oncol Rep 17:813-6. 2007
    ....
  9. pmc Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells
    V Di Marzo
    Istituto per la Chimica di Molecole di Interesse Biologico, Via Toiano 6, 80072, Arco Felice, Napoli, Italy
    Biochem J 358:249-55. 2001
    ..We suggest that long-term PEA treatment of cells may positively affect the pharmacological activity of AEA, in part by inhibiting FAAH expression...
  10. ncbi Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation
    D Melck
    Istituto per la Chimica di Molecole di Interesse Biologico, Consiglio Nazionale delle Ricerche, Arco Felice Na, Italy
    Endocrinology 141:118-26. 2000
    ..These findings suggest that endogenous cannabinoids and CB1 receptor agonists are potential negative effectors of PRL- and NGF-induced biological responses, at least in some cancer cells...
  11. pmc The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation
    L De Petrocellis
    Istituto di Cibernetica, Consiglio Nazionale delle Ricerche, Consiglio Nazionale delle Ricerche, Via Toiano 6, 80072 Arco Felice, Naples, Italy
    Proc Natl Acad Sci U S A 95:8375-80. 1998
    ..These data suggest that anandamide blocks human breast cancer cell proliferation through CB1-like receptor-mediated inhibition of endogenous prolactin action at the level of prolactin receptor...
  12. ncbi Unsaturated long-chain N-acyl-vanillyl-amides (N-AVAMs): vanilloid receptor ligands that inhibit anandamide-facilitated transport and bind to CB1 cannabinoid receptors
    D Melck
    Istituto per la Chimica di Molecole di Interesse Biologico, , 80131, Napoli, Italy
    Biochem Biophys Res Commun 262:275-84. 1999
    ..e., the inhibition of human breast cancer cell (HBCC) proliferation, arvanil was shown to behave as a "hybrid" activator of cannabinoid and vanilloid receptors...
  13. ncbi Inhibitory effects of cannabinoid CB1 receptor stimulation on tumor growth and metastatic spreading: actions on signals involved in angiogenesis and metastasis
    Giuseppe Portella
    Endocannabinoid Research Group, Istituto di Endocrinologia ed Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, and Dipartimento di Biologia e Patologia Cellulare e Molecolare L Califano, Universita di Napoli Federico II, Italy
    FASEB J 17:1771-3. 2003
    ..Our findings indicate that CB1 receptor agonists might be used therapeutically to retard tumor growth in vivo by inhibiting at once tumor growth, angiogenesis, and metastasis...
  14. ncbi Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene expression in FRTL-5 cells. II. Down-regulation by v-K-ras oncogene
    B Perillo
    Dipartimento di Biologia e Patologia Cellulare e Molecolare L Califano, Universita Federico II, Napoli, Italy
    J Biol Chem 270:15237-41. 1995
    ..This is the first demonstration that active v-K-ras down-regulates HMG-CoA reductase expression...
  15. ncbi Apoptosis induced by denied adhesion to extracellular matrix (anoikis) in thyroid epithelial cells is p53 dependent but fails to correlate with modulation of p53 expression
    M Vitale
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita Federico II, Via S Pansini 5, 80131, Naples, Italy
    FEBS Lett 462:57-60. 1999
    ..The phosphatase inhibitor sodium orthovanadate opposed anoikis when added to the cells within 6 h, suggesting a role for phosphorylated proteins...
  16. pmc Rimonabant (SR141716) exerts anti-proliferative and immunomodulatory effects in human peripheral blood mononuclear cells
    A M Malfitano
    Dipartimento di Scienze Farmaceutiche, Universita di Salerno, Fisciano SA, Italy
    Br J Pharmacol 153:1003-10. 2008
    ..In this study we have investigated the anti-proliferative and immunomodulatory effects of SR141716 in human peripheral blood mononuclear cells (PBMCs)...
  17. ncbi Anandamide inhibits adhesion and migration of breast cancer cells
    Claudia Grimaldi
    Dipartimento di Scienze Farmaceutiche, Endocannabinoid Research Group, , Fisciano SA, Italy
    Exp Cell Res 312:363-73. 2006
    ....
  18. ncbi Dietary and hypothyroid hypercholesterolemia induces hepatic apolipoprotein E expression in the rat: direct role of cholesterol
    M Santillo
    Dipartimento di Neuroscienze e della Comunicazione Interumana Sezione di Fisiologia, Universita di Napoli Federico II, Napoli, Italy
    FEBS Lett 463:83-6. 1999
    ..Our data demonstrate that hypercholesterolemia, apart of the cause (diet or hypothyroidism) induces liver apo E expression in the rat and that this effect can be directly related, via cAMP, to cholesterol...
  19. doi The anandamide analog, Met-F-AEA, controls human breast cancer cell migration via the RHOA/RHO kinase signaling pathway
    Chiara Laezza
    Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Napoli, Italy
    Endocr Relat Cancer 15:965-74. 2008
    ..We suggest that the inhibitory effect of Met-F-AEA on tumor cell migration could be related to RHOA-ROCK-dependent signaling pathway...
  20. ncbi Antiangiogenic activity of the endocannabinoid anandamide: correlation to its tumor-suppressor efficacy
    Simona Pisanti
    Department of Pharmaceutical Sciences, University of Salerno, Fisciano, Salerno, Italy
    J Cell Physiol 211:495-503. 2007
    ..Thus, our results suggest that anandamide could be involved in the control of cancer growth targeting both tumor cell proliferation and the angiogenic stimulation of the vasculature...
  21. doi Rimonabant inhibits human colon cancer cell growth and reduces the formation of precancerous lesions in the mouse colon
    Antonietta Santoro
    Department of Pharmaceutical Sciences, University of Salerno, Fisciano, Italy
    Int J Cancer 125:996-1003. 2009
    ..Our findings suggest that rimonabant is able to inhibit colorectal cancer cell growth at different stages of colon cancer pathogenesis inducing mitotic catastrophe in vitro...
  22. ncbi Inhibitors of Ras farnesylation revert the increased resistance to oxidative stress in K-Ras transformed NIH 3T3 cells
    M Santillo
    Dipartimento di Neuroscienze, Sezione Fisiologia, Universita degli Studi di Napoli Federico II, Napoli, Italy
    Biochem Biophys Res Commun 229:739-45. 1996
    ..These results suggest that farnesylation inhibitors could be used as an adjuvant therapy to improve the tumoricidal effect of cancer treatment based upon free-radical production in ras-dependent tumors...
  23. ncbi Effect on cancer cell proliferation of palmitoylethanolamide, a fatty acid amide interacting with both the cannabinoid and vanilloid signalling systems
    Luciano De Petrocellis
    Istituto di Cibernetica Eduardo Caianiello, Consiglio Nazionale delle Ricerche, Comprensorio Olivetti, Pozzuoli, Napoli, Italy
    Fundam Clin Pharmacol 16:297-302. 2002
    ..These 'entourage' effects of PEA might be attributable to modulation of VR1 activity, and could underlie the enhancement by PEA, described here for the first time, of the antiproliferative effects of VR1 receptor agonists...
  24. ncbi Presence of CuZn superoxide dismutase in human serum lipoproteins
    P Mondola
    Dipartimento di Neuroscienze e della Comunicazione Interumana Sez Fisiologia, Via S Pansini 5, 80131, Naples, Italy
    FEBS Lett 467:57-60. 2000
    ..The CuZn-SOD bound to LDL and HDL could exert a physiological protective role against oxidative damage of these lipoprotein classes that carry out a crucial role in the cholesterol transport...
  25. ncbi Effect of Cu,Zn superoxide dismutase on cholesterol metabolism in human hepatocarcinoma (HepG2) cells
    Paolo Mondola
    Dipartimento di Neuroscienze e Scienze del Comportamento, Sezione di Fisiologia, Universita Degli Studi Di Napoli, Federico II, Via S Pansini, 5, 80131 Naples, Italy
    Biochem Biophys Res Commun 295:603-9. 2002
    ....
  26. ncbi Arvanil inhibits T lymphocyte activation and ameliorates autoimmune encephalomyelitis
    Anna Maria Malfitano
    Dipartimento di Scienze Farmaceutiche, Universita di Salerno, via Ponte Don Melillo 84084 Fisciano Salerno, Italy
    J Neuroimmunol 171:110-9. 2006
    ..Our findings have relevance for the use of arvanil and related compounds as a novel immunotherapeutic approach in the treatment of multiple sclerosis...
  27. ncbi Lovastatin-induced apoptosis in thyroid cells: involvement of cytochrome c and lamin B
    T Di Matola
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita Federico II, Via S Pansini 5, 80131, Naples, Italy
    Eur J Endocrinol 145:645-50. 2001
    ..CONCLUSIONS: These data demonstrate that, in TAD-2 thyroid cells, lovastatin induces lamin B proteolysis and inhibits its nuclear localization and induces cytochrome c release from mitochondria into the cytosol...
  28. ncbi Plasma membrane and lysosomal localization of CB1 cannabinoid receptor are dependent on lipid rafts and regulated by anandamide in human breast cancer cells
    Daniela Sarnataro
    Dip di Scienze Farmaceutiche, Universita degli Studi di Salerno, Italy
    FEBS Lett 579:6343-9. 2005
    ..Indeed MCD completely blocked the clustering of CB1R at the plasma membrane. On the contrary the lysosomal localization of CB1R was impaired by this treatment only after AEA binding...
  29. ncbi The cannabinoid CB1 receptor antagonist rimonabant (SR141716) inhibits human breast cancer cell proliferation through a lipid raft-mediated mechanism
    Daniela Sarnataro
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano Salerno, Italy
    Mol Pharmacol 70:1298-306. 2006
    ..Taken together, our results suggest that SR141716 inhibits human breast cancer cell growth via a CB1R lipid raft/caveolae-mediated mechanism...
  30. ncbi HMG-CoA reductase inhibitors inhibit rat propylthiouracil-induced goiter by modulating the ras-MAPK pathway
    Chiara Laezza
    Dipartimento di Scienze Farmaceutiche, Universita di Salerno, Via Ponte Don Melillo, 84084, Fisciano, Salerno, Italy
    J Mol Med (Berl) 84:967-73. 2006
    ..Our data suggest that lovastatin is an efficient inhibitor of goitrogenesis and provide a rationale for innovative therapeutic strategies employing statins in the treatment of nodular goiter in humans...
  31. ncbi Synergistic inhibition of human colon cancer cell growth by the cannabinoid CB1 receptor antagonist rimonabant and oxaliplatin
    Patrizia Gazzerro
    Dipartimento di Scienze Farmaceutiche, Universita di Salerno, Fisciano Salerno, Italy
    Oncol Rep 23:171-5. 2010
    ..Our findings suggest that the combined synergic effect of SR141716 and oxaliplatin improves the blocking of colon cancer cell proliferation. Therefore, this combination merits further explorations in preclinical and clinical settings...
  32. ncbi Protection of human endothelial cells from oxidative stress: role of Ras-ERK1/2 signaling
    Giovanni Cuda
    Dipartimento di Medicina Sperimentale e Clinica G Salvatore, Università di Catanzaro Magna Graecia, Napoli, Italy
    Circulation 105:968-74. 2002
    ..Moreover, ERK1/2 signaling has been involved in both protection and induction of apoptosis...
  33. ncbi Lovastatin enhances the replication of the oncolytic adenovirus dl1520 and its antineoplastic activity against anaplastic thyroid carcinoma cells
    Silvana Libertini
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Via S Pansini 5, 80131, Napoli, Italy
    Endocrinology 148:5186-94. 2007
    ..Lovastatin treatment could be exploited to increase the efficacy of oncolytic adenoviruses, and further studies are warranted to confirm the feasibility of the approach in ATC patients...
  34. ncbi Metabolically labile cannabinoid esters: a 'soft drug' approach for the development of cannabinoid-based therapeutic drugs
    F Minutolo
    Dipartimento di Scienze Farmaceutiche, Universita di Pisa, Via Bonanno 6, 56126, Pisa, Italy
    Bioorg Med Chem Lett 17:4878-81. 2007
    ..This may constitute a possible solution to the psychotropic side effects encountered when cannabinoids are therapeutically employed as local analgesic or antiglaucoma agents...
  35. ncbi Biological and pharmacological roles of N6-isopentenyladenosine: an emerging anticancer drug
    Maurizio Bifulco
    Dipartmento di Scienze Farmaceutiche, Universita di Salerno, 84084 Fisciano, SA, Italy
    Anticancer Agents Med Chem 8:200-4. 2008
    ..In addition, preliminary clinical observation seems to indicate a possible use of N6-Isopentenyladenosine as anticancer drug...
  36. doi Rimonabant-induced apoptosis in leukemia cell lines: activation of caspase-dependent and -independent pathways
    Dario Gallotta
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano SA, Italy
    Biochem Pharmacol 80:370-80. 2010
    ..Moreover, SR141716 negatively modulated, especially in U937, the PI3K/AKT pathways. In conclusion, our data indicate that SR141716 elicits alternative response and/or cell death pathways depending on the cell type affected...
  37. doi N6-isopentenyladenosine inhibits cell proliferation and induces apoptosis in a human colon cancer cell line DLD1
    Chiara Laezza
    Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Naples, Italy
    Int J Cancer 124:1322-9. 2009
    ..Overall, our data show that JNK, could play an important role in i6A-mediated apoptosis in DLD1 human colon cancer cells...
  38. doi Cannabinoid receptor CB1 antagonists state of the art and challenges
    Maurizio Bifulco
    Dipartimento di Scienze Farmaceutiche, Universita di Salerno, Fisciano, Salerno, Italy
    Vitam Horm 81:159-89. 2009
    ....
  39. ncbi Rimonabant: just an antiobesity drug? Current evidence on its pleiotropic effects
    Maurizio Bifulco
    Department of Pharmaceutical Sciences, University of Salerno, Fisciano, Salerno, Italy
    Mol Pharmacol 71:1445-56. 2007
    ..Here we review recent data from the literature and discuss the full pharmacological potential of this drug...
  40. ncbi Anandamide inhibits Cdk2 and activates Chk1 leading to cell cycle arrest in human breast cancer cells
    Chiara Laezza
    IEOS CNR, Napoli, Italy
    FEBS Lett 580:6076-82. 2006
    ..The observed mechanism of action, already reported for well-known chemotherapeutic drugs, provides strong evidence for a direct role of anandamide related compounds in the activation of cell cycle checkpoints...
  41. ncbi The endocannabinoid system and its therapeutic exploitation
    Vincenzo Di Marzo
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, National Research Council, Via Campi Flegrei 34, Comprensorio Olivetti, 80078 Pozzuoli, Napoli, Italy
    Nat Rev Drug Discov 3:771-84. 2004
    ..We explore the conditions under which the potential of targeting the endocannabinoid system might be realized in the years to come...
  42. doi Involvement of Akt/NF-κB pathway in N6-isopentenyladenosine-induced apoptosis in human breast cancer cells
    Chiara Laezza
    Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Naples, Italy
    Mol Carcinog 49:892-901. 2010
    ..The results of this study indicate that i6A decreases cell proliferation and induces apoptotic cell death in human breast cancer cells, possibly by decreasing signal transduction through the Akt/NF-κB cell survival pathway...
  43. doi The cannabinoid CB1 receptor antagonist rimonabant stimulates 2-deoxyglucose uptake in skeletal muscle cells by regulating the expression of phosphatidylinositol-3-kinase
    Iolanda Esposito
    Dipartimento di Biologia e Patologia Cellulare e Molecolare and Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Universita degli Studi di Napoli Federico II, Napoli, Italy
    Mol Pharmacol 74:1678-86. 2008
    ..Thus, modulation of CB1 regulates glucose uptake at the level of the PI3K signaling system in skeletal muscle cells. Interfering with CB1 signaling may therefore ameliorate glucoregulatory functions in peripheral tissues...
  44. doi Therapeutic potential of statins in thyroid proliferative disease
    Maurizio Bifulco
    Department of Pharmaceutical Sciences, University of Salerno, Via Ponte Don Melillo, 84084 Fisciano Salerno, Italy
    Nat Clin Pract Endocrinol Metab 4:242-3. 2008
  45. ncbi Effect of unsaturated fat intake from Mediterranean diet on rat liver mRNA expression profile: selective modulation of genes involved in lipid metabolism
    Davide Eletto
    Dipartimento di Scienze Farmaceutiche, Universita di Salerno, Via Ponte Don Melillo, I 84084 Fisciano SA, Italy
    Nutr Metab Cardiovasc Dis 15:13-23. 2005
    ..We investigated whether the short term nutritional effect of a fat quota mainly derived from olive and fish oil affects liver mRNA expression profile in rats...
  46. doi Endocannabinoids in endocrine and related tumours
    Maurizio Bifulco
    Dipartimento di Scienze Farmaceutiche, Universita di Salerno, 84084 Fisciano Salerno, Italy IEOS, CNR Napoli, 80131 Napoli, Italy
    Endocr Relat Cancer 15:391-408. 2008
    ....
  47. doi Verminoside- and verbascoside-induced genotoxicity on human lymphocytes: involvement of PARP-1 and p53 proteins
    Antonietta Santoro
    Department of Pharmaceutical Sciences, University of Salerno, Via Ponte Don Melillo, 84084 Fisciano, Salerno, Italy
    Toxicol Lett 178:71-6. 2008
    ....
  48. ncbi From cannabis to endocannabinoids in multiple sclerosis: a paradigm of central nervous system autoimmune diseases
    Anna Maria Malfitano
    Dipartimento di Scienze Farmaceutiche, Universita di Salerno, Fisciano SA, Italy
    Curr Drug Targets CNS Neurol Disord 4:667-75. 2005
    ....
  49. ncbi The N-terminal domain of 2',3'-cyclic nucleotide 3'-phosphodiesterase harbors a GTP/ATP binding site
    Stefania Stingo
    Dipartimento di Scienze Farmaceutiche, Universita di Salerno, Via Ponte Don Melillo, Fisciano SA 84084, Italy
    Chem Biol Drug Des 70:502-10. 2007
    ..Therefore, our findings suggest new functional and structural property of the N-terminal domain of CNPase...
  50. ncbi Arvanil and anandamide up-regulate CD36 expression in human peripheral blood mononuclear cells
    Anna Maria Malfitano
    Dipartimento di Scienze Farmaceutiche, Universita di Salerno, Fisciano SA, Italy
    Immunol Lett 109:145-54. 2007
    ..We showed a transcriptional control of the CD36 gene by arvanil and anandamide associated with an increased protein expression, thus suggesting a possible role of CD36 in anandamide and arvanil anti-inflammatory pattern...
  51. ncbi Structures and micelle locations of the nonlipidated and lipidated C-terminal membrane anchor of 2',3'-cyclic nucleotide-3'-phosphodiesterase
    Cinzia Esposito
    Department of Pharmaceutical Sciences, University of Salerno, I 84084 Fisciano, Italy
    Biochemistry 47:308-19. 2008
    ..A general model is proposed in which the post-translational lipidation is an important biomolecular trick to enlarge the hydrophobic surface and to enable the contact of the protein with membrane...
  52. ncbi Arvanil-induced inhibition of spasticity and persistent pain: evidence for therapeutic sites of action different from the vanilloid VR1 receptor and cannabinoid CB(1)/CB(2) receptors
    Jason W Brooks
    Pain Research Group, Department of Anaesthetics, Faculty of Medicine, Imperial College, Chelsea and Westminster Hospital Campus, London, UK
    Eur J Pharmacol 439:83-92. 2002
    ..These findings suggest that activation by arvanil of sites of action different from cannabinoid CB(1)/CB(2) receptors and vanilloid VR1 receptors leads to anti-spastic/analgesic effects that might be exploited therapeutically...
  53. ncbi Possible endocannabinoid control of colorectal cancer growth
    Alessia Ligresti
    Endovannabinoid Research Group, Institute of Biomolecular Chemistry, Pozzuoli, Italy
    Gastroenterology 125:677-87. 2003
    ..the effects of endocannabinoids, and of inhibitors of their inactivation, on human CRC cell proliferation...
  54. ncbi Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma
    Alessia Ligresti
    Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche Pozzuoli, Italy
    J Pharmacol Exp Ther 318:1375-87. 2006
    ..Our data support the further testing of cannabidiol and cannabidiol-rich extracts for the potential treatment of cancer...
  55. ncbi Estrogenic regulation of cholesterol biosynthesis and cell growth in DLD-1 human colon cancer cells
    Caterina Messa
    Laboratory of Biochemistry, National Institute for Digestive Diseases, S de Bellis, Bari, Italy
    Scand J Gastroenterol 40:1454-61. 2005
    ..The effect of 17beta-estradiol on both cell growth and apoptosis in this cell line was also investigated...
  56. ncbi N6-isopentenyladenosine arrests tumor cell proliferation by inhibiting farnesyl diphosphate synthase and protein prenylation
    Chiara Laezza
    Istituto di Endocrinologia e Oncologia Sperimentale I E O S, CNR, Bari, Italy
    FASEB J 20:412-8. 2006
    ..Our findings indicate that this isoprenoid end product might be used for antineoplastic therapy, an application emulating that of the lovastatin and/or farnesyl-transferase inhibitors..
  57. doi Reply to the letter to the editor "Long-term cannabinoid receptor (CB1) blockade in obesity: implications for the development of colorectal cancer"
    Antonietta Santoro
    Int J Cancer 123:243-4. 2008
  58. ncbi Estrogenic induction of cannabinoid CB1 receptor in human colon cancer cell lines
    Maria Notarnicola
    Laboratory of Biochemistry, National Institute for Digestive Diseases S de Bellis, Castellana Grotte, Bari, Italy
    Scand J Gastroenterol 43:66-72. 2008
    ....
  59. ncbi Higher farnesyl diphosphate synthase activity in human colorectal cancer inhibition of cellular apoptosis
    Maria Notarnicola
    Laboratory of Biochemistry, National Institute for Digestive Diseases, Castellana Grotte, Bari, Italy
    Oncology 67:351-8. 2004
    ....
  60. ncbi In vivo pharmacological actions of two novel inhibitors of anandamide cellular uptake
    Eva de Lago
    Departamento de Bioquimica y Biologia Molecular III, Facultad de Medicina, Universidad Complutense, Ciudad Universitaria s n, Madrid 28040, Spain
    Eur J Pharmacol 484:249-57. 2004
    ....
  61. ncbi Possible relationship between statin use and decreased prevalence, number, and volume of thyroid nodules: a new indication for these drugs?
    Maurizio Bifulco
    Thyroid 17:903. 2007
  62. doi In memory of Nino Salvatore: tenth anniversary
    Maurizio Bifulco
    Thyroid 18:91-2. 2008
  63. ncbi Helicobacter pylori has stimulatory effects on naive T cells
    Anna Maria Malfitano
    Department of Infectious Diseases and Microbiology, Hammersmith Campus, Imperial College London, London, UK
    Helicobacter 11:21-30. 2006
    ..Unexpectedly, T cells from apparently uninfected individuals respond to H. pylori antigen by proliferating. Also, the T-cell proliferative response appears to be less in infected compared with uninfected individuals...