P Barone

Summary

Affiliation: Federico II University
Country: Italy

Publications

  1. ncbi Paradoxical response to apomorphine in a case of atypical parkinsonism
    Giulio Cicarelli
    Department of Neurological Sciences, Universita Federico II, Napoli, Italy
    Mov Disord 17:604-6. 2002
  2. ncbi Sumanirole versus placebo or ropinirole for the adjunctive treatment of patients with advanced Parkinson's disease
    Paolo Barone
    Department of Neurological Sciences, University Federico II, Napoli, Italy
    Mov Disord 22:483-9. 2007
  3. pmc Depression rating scales in Parkinson's disease: critique and recommendations
    Anette Schrag
    University Department of Clinical Neurosciences, Royal Free and University College Medical School, London, UK
    Mov Disord 22:1077-92. 2007
  4. doi Neurotransmission in Parkinson's disease: beyond dopamine
    P Barone
    Dipartimento di Scienze Neurologiche and IDC Hermitage Capodimonte, Naples, Italy
    Eur J Neurol 17:364-76. 2010
  5. ncbi Pramipexole versus sertraline in the treatment of depression in Parkinson's disease: a national multicenter parallel-group randomized study
    Paolo Barone
    Department of Neurological Sciences, University of Naples Federico II, Via Pansini 5, 80131, Napoli, Italy
    J Neurol 253:601-7. 2006
  6. ncbi Pramipexole for the treatment of depressive symptoms in patients with Parkinson's disease: a randomised, double-blind, placebo-controlled trial
    Paolo Barone
    Department of Neurological Sciences, University of Naples Federico II and IDC Hermitage Capodimonte, Naples, Italy
    Lancet Neurol 9:573-80. 2010
  7. ncbi Clinical presentation and treatment of Wilson's disease: a single-centre experience
    M T Pellecchia
    Department of Neurological Sciences, University Federico II, Naples, Italy
    Eur Neurol 50:48-52. 2003
  8. doi Cognitive impairment in nondemented Parkinson's disease
    Paolo Barone
    Department of Neurological Sciences, University Federico II ICD Hermitage, Capodimonte, Naples, Italy
    Mov Disord 26:2483-95. 2011
  9. doi Rivastigmine versus placebo in hyperhomocysteinemic Parkinson's disease dementia patients
    Paolo Barone
    Dipartimento di Scienze Neurologiche, Universita Federico II di Napoli, Naples, Italy
    Mov Disord 23:1532-40. 2008
  10. doi Treatment of depressive symptoms in Parkinson's disease
    P Barone
    Department of Neurological Sciences, University of Napoli Federico II IDC Hermitage Capodimonte, Naples, Italy
    Eur J Neurol 18:11-5. 2011

Detail Information

Publications65

  1. ncbi Paradoxical response to apomorphine in a case of atypical parkinsonism
    Giulio Cicarelli
    Department of Neurological Sciences, Universita Federico II, Napoli, Italy
    Mov Disord 17:604-6. 2002
    ..We discuss possible pathogenetic mechanisms with regard to the literature and suggest the diagnosis of a striatonigral degeneration at an early stage...
  2. ncbi Sumanirole versus placebo or ropinirole for the adjunctive treatment of patients with advanced Parkinson's disease
    Paolo Barone
    Department of Neurological Sciences, University Federico II, Napoli, Italy
    Mov Disord 22:483-9. 2007
    ..Noninferiority of sumanirole to ropinirole was established, with comparable tolerability profiles...
  3. pmc Depression rating scales in Parkinson's disease: critique and recommendations
    Anette Schrag
    University Department of Clinical Neurosciences, Royal Free and University College Medical School, London, UK
    Mov Disord 22:1077-92. 2007
    ..The complex and time-consuming task of developing a new scale to measure depression specifically for patients with PD is currently not warranted...
  4. doi Neurotransmission in Parkinson's disease: beyond dopamine
    P Barone
    Dipartimento di Scienze Neurologiche and IDC Hermitage Capodimonte, Naples, Italy
    Eur J Neurol 17:364-76. 2010
    ..The development of agents that interact with several of the affected neurotransmission systems could prove invaluable for the treatment of this disease...
  5. ncbi Pramipexole versus sertraline in the treatment of depression in Parkinson's disease: a national multicenter parallel-group randomized study
    Paolo Barone
    Department of Neurological Sciences, University of Naples Federico II, Via Pansini 5, 80131, Napoli, Italy
    J Neurol 253:601-7. 2006
    ..We conclude that dopamine agonists may be an alternative to antidepressants in Parkinson's disease...
  6. ncbi Pramipexole for the treatment of depressive symptoms in patients with Parkinson's disease: a randomised, double-blind, placebo-controlled trial
    Paolo Barone
    Department of Neurological Sciences, University of Naples Federico II and IDC Hermitage Capodimonte, Naples, Italy
    Lancet Neurol 9:573-80. 2010
    ....
  7. ncbi Clinical presentation and treatment of Wilson's disease: a single-centre experience
    M T Pellecchia
    Department of Neurological Sciences, University Federico II, Naples, Italy
    Eur Neurol 50:48-52. 2003
    ..Our results suggest that D-penicillamine or a combination of D-penicillamine and zinc sulphate is a safe and effective long-term treatment in patients with WD...
  8. doi Cognitive impairment in nondemented Parkinson's disease
    Paolo Barone
    Department of Neurological Sciences, University Federico II ICD Hermitage, Capodimonte, Naples, Italy
    Mov Disord 26:2483-95. 2011
    ..We focus on questions that should be addressed in future studies to achieve consensus on its characteristics and definition, pathophysiology, epidemiology, diagnosis and assessment, and treatment and management...
  9. doi Rivastigmine versus placebo in hyperhomocysteinemic Parkinson's disease dementia patients
    Paolo Barone
    Dipartimento di Scienze Neurologiche, Universita Federico II di Napoli, Naples, Italy
    Mov Disord 23:1532-40. 2008
    ..1 on ADCS-CGIC, both P = ns); 16.7% and 10.3% rivastigmine- and placebo-treated patients discontinued because of AEs. Elevated homocysteine was associated with greater rivastigmine treatment differences than normal/low homocysteine...
  10. doi Treatment of depressive symptoms in Parkinson's disease
    P Barone
    Department of Neurological Sciences, University of Napoli Federico II IDC Hermitage Capodimonte, Naples, Italy
    Eur J Neurol 18:11-5. 2011
    ..These data suggest that pramipexole might represent an alternative to antidepressant drugs to treat depressive symptoms in PD without adding the risk of antidepressant adverse events, and avoid polypharmacy...
  11. ncbi Stimulation of growth hormone release in multiple system atrophy, Parkinson's disease and idiopathic cerebellar ataxia
    M T Pellecchia
    Department of Neurological Sciences, University Federico II, Naples, Italy
    Neurol Sci 22:79-80. 2001
    ..We suggest that stimulation of GH release with GHRH-Arg rather than clonidine could differentiate MSA from IPD and ILOCA, but this hypothesis would need to be confirmed by further investigations...
  12. doi Observational study of sleep-related disorders in Italian patients with Parkinson's disease: usefulness of the Italian version of Parkinson's disease sleep scale
    M T Pellecchia
    Department of Neurological Sciences, University of Naples, Federico II, Naples, Italy
    Neurol Sci 33:689-94. 2012
    ..Daytime sleepiness, depressive symptoms and disease severity correlate with sleep disturbances in Italian PD patients. The PDSS is a valid and reliable tool to evaluate sleep disturbances in Italian patients...
  13. doi Mild cognitive impairment in drug-naive patients with PD is associated with cerebral hypometabolism
    Sabina Pappata
    Institute of Biostructure and Bioimaging, CNR, Naples, Italy
    Neurology 77:1357-62. 2011
    ..To characterize brain metabolic changes associated with mild cognitive impairment (MCI) in drug-naive patients with Parkinson disease (PD) using (18)F-fluorodeoxyglucose (FDG) and PET (FDG-PET)...
  14. ncbi Physical therapy in Parkinson's disease: an open long-term rehabilitation trial
    M T Pellecchia
    Department of Neurological Sciences, University Federico II, Ed 17, Via Pansini 5, 80131, Naples, Italy
    J Neurol 251:595-8. 2004
    ..At 3-month follow-up clinical improvements were largely maintained. A sustained improvement of motor skills in PD patients can be achieved with a long-term comprehensive rehabilitation program...
  15. ncbi Unawareness of dyskinesias in Parkinson's and Huntington's diseases
    C Vitale
    Department of Neurological Sciences, University Federico II, Naples, Italy
    Neurol Sci 22:105-6. 2001
    ..In PD the unawareness seems to be inversely related with severity of dyskinesias, while in HD it is directly related to disease duration and severity...
  16. doi Subthreshold depression and subjective cognitive complaints in Parkinson's disease
    G Santangelo
    Department of Psychology, Second University of Naples, Caserta, Italy IDC Hermitage Capodimonte, Naples, Italy
    Eur J Neurol 21:541-4. 2014
    ..The possible association of SubD with subjective cognitive complaints and/or objective cognitive impairments was investigated in a sample of consecutive, non-demented Parkinson's disease (PD) outpatients...
  17. doi Regional gray matter atrophy in patients with Parkinson disease and freezing of gait
    A Tessitore
    Department of Neurological Sciences, Second University of Naples, Naples, Italy
    AJNR Am J Neuroradiol 33:1804-9. 2012
    ..FOG is a troublesome symptom of PD. Despite growing evidence suggesting that FOG in PD may be associated with cognitive dysfunction, the relationship between regional brain atrophy and FOG has been poorly investigated...
  18. ncbi Imaging of dopaminergic dysfunction with [123I]FP-CIT SPECT in early-onset parkin disease
    A Varrone
    Biostructure and Bioimaging Institute, National Research Council, Via S Pansini, 5, 80131, Napoli, Italy
    Neurology 63:2097-103. 2004
    ..To investigate whether the presence of parkin gene mutations is associated with different nigrostriatal impairment than other early-onset parkinsonism...
  19. ncbi The diverse phenotype and genotype of pantothenate kinase-associated neurodegeneration
    M T Pellecchia
    Department of Neurological Sciences, University Federico II, Naples, Italy
    Neurology 64:1810-2. 2005
    ..Only nine patients could be classified as classic or atypical PKAN, and intermediate phenotypes are described. Two patients presented with motor tics and obsessive-compulsive behavior suggestive of Tourette syndrome...
  20. doi Patient-reported convenience of once-daily versus three-times-daily dosing during long-term studies of pramipexole in early and advanced Parkinson's disease
    A H V Schapira
    Department of Clinical Neurosciences, University College London Institute of Neurology, London, UK Università di Napoli Federico II IDC Hermitage Capodimonte, Napoli, Italy
    Eur J Neurol 20:50-6. 2013
    ..However, blinded clinical-trial designs preclude direct comparisons of adherence to various schedules...
  21. ncbi The GH-IGF system in amyotrophic lateral sclerosis: correlations between pituitary GH secretion capacity, insulin-like growth factors and clinical features
    M T Pellecchia
    Department of Neurological Sciences and Molecular, Federico II University, Naples, Italy
    Eur J Neurol 17:666-71. 2010
    ..Our aim was to investigate the GH-IGF axis in patients with ALS and evaluate correlations between this endocrine system and clinical features...
  22. doi DRD3 Ser9Gly variant is not associated with essential tremor in a series of Italian patients
    C Vitale
    Department of Neurological Sciences, Institute of Diagnosis e Therapy, University Federico II, Naples
    Eur J Neurol 15:985-7. 2008
    ..Three susceptibility loci on chromosomes 3q13, 2p24.1, and 6p23 have been reported, but no causative genes were found. The Ser9Gly variant of dopamine D3 receptor (DRD3) receptor was found associated to ET in a French and US population...
  23. ncbi Clinical and neurological abnormalities in adult celiac disease
    G Cicarelli
    Department of Neurological Sciences, Federico II University of Naples, Via S Pansini 5, I 80131 Naples, Italy
    Neurol Sci 24:311-7. 2003
    ..Neurological signs and symptoms are associated with celiac disease and can be ameliorated by a gluten-free diet...
  24. ncbi Clinical strategies to prevent and delay motor complications
    Paolo Barone
    Department of Neurological Sciences, University Federico II, Naples, Italy
    Neurology 61:S12-6. 2003
    ....
  25. doi Anhedonia and cognitive impairment in Parkinson's disease: Italian validation of the Snaith-Hamilton Pleasure Scale and its application in the clinical routine practice during the PRIAMO study
    G Santangelo
    Universita Federico II, Napoli, Napoli, Italy
    Parkinsonism Relat Disord 15:576-81. 2009
    ..To assess the psychometric properties of the Italian version of the Snaith-Hamilton Pleasure Scale (SHAPS) and to study the relationship between anhedonia, depression and cognitive impairment in patients with Parkinson's disease (PD)...
  26. ncbi Pure unilateral hyperhidrosis after pontine infarct
    M T Pellecchia
    Department of Neurological Sciences, University Federico II, Naples, Italy
    Neurology 61:1305. 2003
  27. ncbi Freezing of gait and executive functions in patients with Parkinson's disease
    Marianna Amboni
    Department of Neurological Sciences, University Federico II, Naples, Italy
    Mov Disord 23:395-400. 2008
    ..008; phonemic verbal fluency: P = 0.011; TPCT: P = 0.024). FOG correlated with lower scores at frontal tests in patients with early-stage PD...
  28. doi Dopamine receptor agonists and depression in Parkinson's disease
    Marina Picillo
    Department of Neurological Sciences, University of Naples Federico II, Naples, Italy
    Parkinsonism Relat Disord 15:S81-4. 2009
    ..Treatment strategies for depressive symptoms in PD should include optimization of dopaminergic treatment prior to the addition of classic antidepressant drugs, thus reducing the risk of side-effects associated with multi-drug therapies...
  29. ncbi Treatment of nocturnal disturbances and excessive daytime sleepiness in Parkinson's disease
    Paolo Barone
    Department of Neurological Sciences, University of Napoli Federico II, Via Pansini 5, 80131 Naples, Italy
    Neurology 63:S35-8. 2004
    ..Some sleep disorders, such as RLS and PLMS, may be controlled by DA agents, and others, such as insomnia and EDS, may be improved by reducing dopaminergic stimulation...
  30. ncbi Frontal dysfunction contributes to the genesis of hallucinations in non-demented Parkinsonian patients
    Dario Grossi
    Department of Psychology, Second University, Naples, Italy
    Int J Geriatr Psychiatry 20:668-73. 2005
    ..Hallucinations are significantly associated with dementia in PD, but little is known about possible distinctive cognitive features of non-demented PD patients who develop hallucinations...
  31. ncbi Multiple system atrophy is distinguished from idiopathic Parkinson's disease by the arginine growth hormone stimulation test
    Maria Teresa Pellecchia
    Department of Neurological Sciences, University of Naples Federico II, Naples, Italy
    Ann Neurol 60:611-5. 2006
    ..Our aim was to evaluate the accuracy of the arginine growth hormone (GH) stimulation test in distinguishing between MSA and PD in large populations of patients...
  32. ncbi Ropinirole as a treatment of restless legs syndrome in patients on chronic hemodialysis: an open randomized crossover trial versus levodopa sustained release
    Maria Teresa Pellecchia
    Department of Neurological Sciences, University Federico II, Naples, Italy
    Clin Neuropharmacol 27:178-81. 2004
    ..RLS is present in 20-40% of patients with renal failure. This study was a 14-week open, randomized, crossover trial of ropinirole vs. levodopa sustained release (SR) in 11 patients with RLS on chronic hemodialysis...
  33. ncbi Short-term continuous infusion of apomorphine hydrochloride for treatment of Huntington's chorea: A double blind, randomized cross-over trial
    Carmine Vitale
    Department of Neurological Sciences, University Federico II, Naples, Italy
    Mov Disord 22:2359-64. 2007
    ..No serious adverse events were reported by either group during the study. Our results suggest that continuous infusion of apomorphine might be considered for the treatment of involuntary movements in some HD patients...
  34. ncbi Possible gluten sensitivity in multiple system atrophy
    M T Pellecchia
    Department of Neurological Sciences, University Federico II, Naples, Italy
    Neurology 59:1114-5. 2002
  35. doi Relationship between depression and cognitive dysfunctions in Parkinson's disease without dementia
    Gabriella Santangelo
    Dept of Neurological Sciences, University of Naples Federico II, Via S Pansini 5, 80131, Naples, Italy
    J Neurol 256:632-8. 2009
    ..Since such patients are diagnosed to be affected by depression according to clinical DSM-IV criteria, we suggest that DSM-IV criteria may not distinguish an affective from a cognitive disorder in PD...
  36. ncbi A neuropsychological longitudinal study in Parkinson's patients with and without hallucinations
    Gabriella Santangelo
    Dipartimento di Scienze Neurologiche, Universita di Napoli Federico II, Naples, Italy
    Mov Disord 22:2418-25. 2007
    ..We concluded that reduced verbal fluency scores may predict the onset of hallucinations, while hallucinations and poor phonological fluency may predict development of dementia in PD patients...
  37. doi The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease
    Paolo Barone
    Università Federico II and IDC Hermitage Capodimonte, Napoli, Italy
    Mov Disord 24:1641-9. 2009
    ..These findings further support a key role for NMS in the clinical frame of PD and the need to address them specifically in clinical trials using dedicated scales...
  38. doi Cognitive dysfunctions and pathological gambling in patients with Parkinson's disease
    Gabriella Santangelo
    Dipartimento di Scienze Neurologiche, Universita di Napoli Federico II, Via S Pansini 5, Naples, Italy
    Mov Disord 24:899-905. 2009
    ..9; 95% CI: 2.82-277.95, P = 0.004). The results indicate an association between PG and frontal lobe dysfunctions in nondemented patients with PD. Low scores on the FAB indicate patients with PD at high risk for PG...
  39. doi Diffusion-weighted imaging in multiple system atrophy: a comparison between clinical subtypes
    Maria Teresa Pellecchia
    Department of Neurological Sciences, University Federico II, Naples, Italy
    Mov Disord 24:689-96. 2009
    ..Based on our findings, Trace (D) measurements in the putamen and pons in MSA-P patients and in the cerebellum and MCP in MSA-C patients could serve as quantitative markers for microstructural damage in the course of disease...
  40. ncbi The arginine growth hormone stimulation test in bradykinetic-rigid parkinsonisms
    Maria Teresa Pellecchia
    Department of Neurological Sciences, University of Naples Federico II, Naples, Italy
    Mov Disord 23:190-4. 2008
    ..Our results suggest that the impairment of the central mechanisms modulating GH release differs between PSP and MSA-P...
  41. pmc Functional involvement of central cholinergic circuits and visual hallucinations in Parkinson's disease
    Fiore Manganelli
    Department of Neurological Sciences, University Federico II of Naples, Naples, Italy
    Brain 132:2350-5. 2009
    ..A follow-up study of our patients is required to verify whether SAI abnormalities can predict a future severe cognitive decline. Moreover, SAI can also be very useful to follow-up the efficacy of anti-cholinesterase therapies...
  42. doi HOMER1 promoter analysis in Parkinson's disease: association study with psychotic symptoms
    Vincenzo De Luca
    Department of Neuroscience and Behavioural Sciences, Section of Psychiatry, Naples, Italy
    Neuropsychobiology 59:239-45. 2009
    ..Approximately 25-40% of patients with idiopathic PD experience hallucinations. Genetic variability within different candidate genes has been implicated in the clinical severity of sporadic PD in many populations. Materials and..
  43. ncbi Growth hormone response to arginine test distinguishes multiple system atrophy from Parkinson's disease and idiopathic late-onset cerebellar ataxia
    Maria Teresa Pellecchia
    Department of Neurological Sciences, Federico II University, 80131 Naples, Italy
    Clin Endocrinol (Oxf) 62:428-33. 2005
    ..This study aimed to evaluate GH response to three different GH stimulation tests in order to establish a reliable test to differentiate these degenerative disorders...
  44. doi Differential neuropsychological profiles in Parkinsonian patients with or without vascular lesions
    Gabriella Santangelo
    Department of Neurological Sciences, University of Naples Federico II, 80131 Naples, Italy
    Mov Disord 25:50-6. 2010
    ....
  45. ncbi Identification by [99mTc]ECD SPECT of anterior cingulate hypoperfusion in progressive supranuclear palsy, in comparison with Parkinson's disease
    Andrea Varrone
    Biostructure and Bioimaging Institute, National Research Council Department of Biomorphological and Functional Sciences, University Federico II, Napoli, Italy
    Eur J Nucl Med Mol Imaging 34:1071-81. 2007
    ....
  46. pmc Growth hormone stimulation tests in the differential diagnosis of Parkinson's disease
    Maria Teresa Pellecchia
    Department of Neurological Sciences, University Federico II, Via Pansini 5, 80131 Naples, Italy
    Clin Med Res 4:322-5. 2006
    ..This review summarizes the results of several studies and discusses the validity of these tests in the differential diagnosis of parkinsonisms...
  47. ncbi Comparison between a dual-head and a brain-dedicated SPECT system in the measurement of the loss of dopamine transporters with [123I]FP-CIT
    Andrea Varrone
    Biostructure and Bioimaging Institute, National Research Council Department of Biomorphological and Functional Sciences, University Federico II, Napoli, Italy
    Eur J Nucl Med Mol Imaging 35:1343-9. 2008
    ..There are limited data comparing the capability of the two types of system to measure dopamine transporter (DAT) loss in vivo...
  48. ncbi Randomized study of sertraline and low-dose amitriptyline in patients with Parkinson's disease and depression: effect on quality of life
    Angelo Antonini
    Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy
    Mov Disord 21:1119-22. 2006
    ..However, the improvement in specific PDQ-39 subscores (mobility, activities of daily living, and stigma) suggests that depression affects patient self-perception of motor function and further emphasizes the need for its treatment...
  49. ncbi MR imaging of middle cerebellar peduncle width: differentiation of multiple system atrophy from Parkinson disease
    Giuseppe Nicoletti
    Institute of Neurological Sciences, National Research Council, Mangone, Cosenza, Italy
    Radiology 239:825-30. 2006
    ..To prospectively assess if middle cerebellar peduncle (MCP) atrophy, evaluated at magnetic resonance (MR) imaging, can help differentiate multiple system atrophy (MSA) from Parkinson disease (PD)...
  50. ncbi A functional polymorphism regulating dopamine beta-hydroxylase influences against Parkinson's disease
    Daniel G Healy
    Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom
    Ann Neurol 55:443-6. 2004
    ..46 (CI = 0.27-0.8). Rather than identifying a haplotype, or a marker in linkage disequilibrium with the risk variant, this to our knowledge is the first report directly linking PD susceptibility with a proven functional variant...
  51. ncbi Apparent diffusion coefficient measurements of the middle cerebellar peduncle differentiate the Parkinson variant of MSA from Parkinson's disease and progressive supranuclear palsy
    Giuseppe Nicoletti
    Institute of Neurological Sciences, National Research Council, Mangone, Cosenza, Italy
    Brain 129:2679-87. 2006
    ..Our findings indicate that, in order to substantially contribute to the in vivo differential diagnosis of MSA-P, PSP and Parkinson's disease, rADC measurements should not be limited to the basal ganglia but should also include the MCP...
  52. ncbi Essential tremor is not associated with alpha-synuclein gene haplotypes
    Simona Pigullo
    Department of Neurosciences, Ophthalmology and Genetics Section of Medical Genetics, University of Genova, Genova, Italy
    Mov Disord 18:823-6. 2003
    ..Our results did not confirm the association reported previously and failed to identify a alpha-synuclein specific haplotype as susceptibility factor for essential tremor...
  53. ncbi Frequency and phenotypes of LRRK2 G2019S mutation in Italian patients with Parkinson's disease
    Roberta Marongiu
    IRCCS CSS, Mendel Institute, Rome
    Mov Disord 21:1232-5. 2006
    ..2%. All presented a typical phenotype with variable onset and shared the common ancestral haplotype. Mutation frequency raised from 1.2% in early onset PD to 4.0% in late onset PD...
  54. ncbi International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease: the NMSQuest study
    Kallol Ray Chaudhuri
    Movement Disorders Unit, Kings College Hospital, University Hospital Lewisham, Guy s King s and St Thomas School of Medicine, London, United Kingdom
    Mov Disord 21:916-23. 2006
    ..Furthermore, frequently, problems such as diplopia, dribbling, apathy, blues, taste and smell problems were never previously disclosed to the health professionals...
  55. ncbi Progression of multiple system atrophy (MSA): a prospective natural history study by the European MSA Study Group (EMSA SG)
    Felix Geser
    Clinical Department of Neurology, Innsbruck Medical University, Austria
    Mov Disord 21:179-86. 2006
    ..Our data contribute to the ongoing validation process of UMSARS, and they facilitate the planning and implementation of future neuroprotective intervention trials...
  56. ncbi Health-related quality of life in multiple system atrophy
    Anette Schrag
    Department of Clinical Neurosciences, Royal Free and University College Medical School, London, United Kingdom
    Mov Disord 21:809-15. 2006
    ....
  57. doi Red flags for multiple system atrophy
    Martin Köllensperger
    Section for Clinical Neurobiology, Department of Neurology, Innsbruck Medical University, Austria
    Mov Disord 23:1093-9. 2008
    ..9 (+/-7.0) months earlier than with the Consensus criteria alone. We propose a combination of two out of six red flag categories as additional diagnostic criteria for probable MSA-P...
  58. doi Pain as a nonmotor symptom of Parkinson disease: evidence from a case-control study
    Giovanni Defazio
    Department of Neurology and Psychiatry, University of Bari, Piazza Giulio Cesare 11, I 70124 Bari, Italy
    Arch Neurol 65:1191-4. 2008
    ..To determine whether pain is more frequent among people with Parkinson disease (PD) than among age-matched controls...
  59. doi PINK1 heterozygous rare variants: prevalence, significance and phenotypic spectrum
    Roberta Marongiu
    IRCCS CSS Mendel Institute, Rome, Italy
    Hum Mutat 29:565. 2008
    ..Hence, their significance should be kept distinct from that of homozygous/compound heterozygous mutations, that cause parkinsonism inherited in a mendelian fashion...
  60. ncbi Apoptotic mechanisms in mutant LRRK2-mediated cell death
    Ciro Iaccarino
    Department of Physiological, Biochemical, and Cell Science, University of Sassari, Via Muroni 25, 07100 Sassari, Italy
    Hum Mol Genet 16:1319-26. 2007
    ..Moreover, we explored the function of two protein domains in LRRK2 (LRR and WD40) and demonstrate that the lack of these protein domains has a protective effect on mitochondria dysfunctions induced by mutant LRRK2...
  61. ncbi Mitochondrial DNA haplogroup K is associated with a lower risk of Parkinson's disease in Italians
    Daniele Ghezzi
    Unit of Molecular Neurogenetics, National Neurological Institute, Carlo Besta, Milan, Italy
    Eur J Hum Genet 13:748-52. 2005
    ..Our study suggests that haplogroup K might confer a lower risk for PD in Italians, corroborating the idea that the mitochondrial oxidative phosphorylation pathway is involved in the susceptibility to idiopathic PD...
  62. ncbi MR imaging index for differentiation of progressive supranuclear palsy from Parkinson disease and the Parkinson variant of multiple system atrophy
    Aldo Quattrone
    Institute of Neurology, Magna Graecia University of Catanzaro, Catanzaro, Calabria, Italy
    Radiology 246:214-21. 2008
    ....
  63. ncbi The metric properties of a novel non-motor symptoms scale for Parkinson's disease: Results from an international pilot study
    Kallol Ray Chaudhuri
    National Parkinson Foundation Centre of Excellence, Kings College Hospital, London, United Kingdom
    Mov Disord 22:1901-11. 2007
    ..70). In conclusion, NMSS can be used to assess the frequency and severity of NMS in PD patients across all stages in conjunction with the recently validated non-motor questionnaire...
  64. ncbi Prevalence of nonmotor symptoms in Parkinson's disease in an international setting; study using nonmotor symptoms questionnaire in 545 patients
    Pablo Martinez-Martin
    Unit of Neuroepidemiology, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain
    Mov Disord 22:1623-9. 2007
    ....
  65. ncbi Reduced striatal [123 I]FP-CIT binding in SCA2 patients without parkinsonism
    Andrea Varrone
    Biostructure and Bioimaging Institute, National Research Council, Via S Pansini 5, 80131 Naples, Italy
    Ann Neurol 55:426-30. 2004
    ..Striatal DAT density of SCA2 patients correlated with the severity of cerebellar ataxia...