R Squitti

Summary

Affiliation: Fatebenefratelli Hospital
Country: Italy

Publications

  1. ncbi Excess of serum copper not related to ceruloplasmin in Alzheimer disease
    R Squitti
    Department of Neuroscience, AFaR Osp Fatebenefratelli, 00186, Rome, Italy
    Neurology 64:1040-6. 2005
  2. ncbi Low-copper diet as a preventive strategy for Alzheimer's disease
    Rosanna Squitti
    Fatebenefratelli Foundation for Health Research and Education, AFaR Division, San Giovanni Calibita Fatebenefratelli Hospital, Rome, Italy Laboratorio di Neurodegenerazione, IRCCS San Raffaele Pisana, Rome, Italy Electronic address
    Neurobiol Aging 35:S40-50. 2014
  3. pmc Ceruloplasmin/Transferrin ratio changes in Alzheimer's disease
    Rosanna Squitti
    Department of Neuroscience, AFaR Fatebenefratelli Hospital, 00186 Rome, Italy
    Int J Alzheimers Dis 2011:231595. 2010
  4. pmc Ceruloplasmin (2-D PAGE) Pattern and Copper Content in Serum and Brain of Alzheimer Disease Patients
    Rosanna Squitti
    AFaR, Dept of Neuroscience, Fatebenefratelli Hospital, Rome, Italy
    Biomark Insights 1:205-13. 2007
  5. ncbi ATP7B variants as modulators of copper dyshomeostasis in Alzheimer's disease
    Rosanna Squitti
    Department of Neuroscience, AFaR Ospedale Fatebenefratelli Hospital, 00186, Rome, Italy
    Neuromolecular Med 15:515-22. 2013
  6. ncbi Metal-score as a potential non-invasive diagnostic test for Alzheimer's disease
    Rosanna Squitti
    Department of Neuroscience, AFaR Ospedale Fatebenefratelli, 00186, Rome, Italy
    Curr Alzheimer Res 10:191-8. 2013
  7. doi Copper dysfunction in Alzheimer's disease: from meta-analysis of biochemical studies to new insight into genetics
    Rosanna Squitti
    Department of Neuroscience, AFaR Osp Fatebenefratelli, Rome, Italy
    J Trace Elem Med Biol 26:93-6. 2012
  8. ncbi Metals in Alzheimer's disease: a systemic perspective
    Rosanna Squitti
    Department of Neuroscience, AFaR, Fatebenefratelli Hospital, Rome, Italy
    Front Biosci (Landmark Ed) 17:451-72. 2012
  9. ncbi Excess of nonceruloplasmin serum copper in AD correlates with MMSE, CSF [beta]-amyloid, and h-tau
    R Squitti
    AFaR Department of Neuroscience, Hospital Fatebenefratelli, Rome, Italy
    Neurology 67:76-82. 2006
  10. ncbi Anti-copper therapies in Alzheimer's disease: new concepts
    Rosanna Squitti
    Department of Neuroscience, AFaR Ospedale Fatebenefratelli, Isola Tiberina, Rome, Italy
    Recent Pat CNS Drug Discov 4:209-19. 2009

Detail Information

Publications29

  1. ncbi Excess of serum copper not related to ceruloplasmin in Alzheimer disease
    R Squitti
    Department of Neuroscience, AFaR Osp Fatebenefratelli, 00186, Rome, Italy
    Neurology 64:1040-6. 2005
    ..To assess the role of serum copper in relation to ceruloplasmin and other peripheral markers of inflammation in Alzheimer disease (AD)...
  2. ncbi Low-copper diet as a preventive strategy for Alzheimer's disease
    Rosanna Squitti
    Fatebenefratelli Foundation for Health Research and Education, AFaR Division, San Giovanni Calibita Fatebenefratelli Hospital, Rome, Italy Laboratorio di Neurodegenerazione, IRCCS San Raffaele Pisana, Rome, Italy Electronic address
    Neurobiol Aging 35:S40-50. 2014
    ....
  3. pmc Ceruloplasmin/Transferrin ratio changes in Alzheimer's disease
    Rosanna Squitti
    Department of Neuroscience, AFaR Fatebenefratelli Hospital, 00186 Rome, Italy
    Int J Alzheimers Dis 2011:231595. 2010
    ..All these findings indicate that the local iron accumulation found in brain areas critical for AD should be viewed in the frame of iron systemic alterations...
  4. pmc Ceruloplasmin (2-D PAGE) Pattern and Copper Content in Serum and Brain of Alzheimer Disease Patients
    Rosanna Squitti
    AFaR, Dept of Neuroscience, Fatebenefratelli Hospital, Rome, Italy
    Biomark Insights 1:205-13. 2007
    ..These data suggest a ceruloplasmin fragmentation in the serum of AD patients. Some clues in this direction have been found also in the AD brain...
  5. ncbi ATP7B variants as modulators of copper dyshomeostasis in Alzheimer's disease
    Rosanna Squitti
    Department of Neuroscience, AFaR Ospedale Fatebenefratelli Hospital, 00186, Rome, Italy
    Neuromolecular Med 15:515-22. 2013
    ..They also suggest that free copper is a risk factor for this disorder, modulating additional pathways leading to the disease cascade...
  6. ncbi Metal-score as a potential non-invasive diagnostic test for Alzheimer's disease
    Rosanna Squitti
    Department of Neuroscience, AFaR Ospedale Fatebenefratelli, 00186, Rome, Italy
    Curr Alzheimer Res 10:191-8. 2013
    ..In conclusion, we confirm the link between biometals and AD and suggest its potential as diagnostic tool. Further studies may elucidate its potential role as reliable diagnostic test...
  7. doi Copper dysfunction in Alzheimer's disease: from meta-analysis of biochemical studies to new insight into genetics
    Rosanna Squitti
    Department of Neuroscience, AFaR Osp Fatebenefratelli, Rome, Italy
    J Trace Elem Med Biol 26:93-6. 2012
    ..Even though copper dysfunction cannot be assumed as a determinant of the disease, its causative, rather than associated, role in AD pathology as risk factor can be claimed...
  8. ncbi Metals in Alzheimer's disease: a systemic perspective
    Rosanna Squitti
    Department of Neuroscience, AFaR, Fatebenefratelli Hospital, Rome, Italy
    Front Biosci (Landmark Ed) 17:451-72. 2012
    ..These findings clearly suggest that local metals accumulation in brain areas critical for AD should be viewed within a wider framework of metals systemic alteration...
  9. ncbi Excess of nonceruloplasmin serum copper in AD correlates with MMSE, CSF [beta]-amyloid, and h-tau
    R Squitti
    AFaR Department of Neuroscience, Hospital Fatebenefratelli, Rome, Italy
    Neurology 67:76-82. 2006
    ..To assess whether serum copper in Alzheimer disease (AD) correlates with cognitive scores, beta-amyloid, and other CSF markers of neurodegeneration...
  10. ncbi Anti-copper therapies in Alzheimer's disease: new concepts
    Rosanna Squitti
    Department of Neuroscience, AFaR Ospedale Fatebenefratelli, Isola Tiberina, Rome, Italy
    Recent Pat CNS Drug Discov 4:209-19. 2009
    ....
  11. ncbi Agents complexing copper as a therapeutic strategy for the treatment of Alzheimer's disease
    Rosanna Squitti
    Department of Neuroscienze, AFaR Ospedale Fatebenefratelli, Isola Tiberina, 00186 Rome, Italy
    Curr Alzheimer Res 6:476-87. 2009
    ..This review summarizes these clinical studies and provides an overview of those in progress and in preparation...
  12. doi Implications of metal exposure and liver function in Parkinsonian patients resident in the vicinities of ferroalloy plants
    Rosanna Squitti
    AFaR Department of Neuroscience, AFaR Fatebenefratelli Hospital, Isola Tiberina, 00186, Rome, Italy
    J Neural Transm 116:1281-7. 2009
    ....
  13. pmc Ceruloplasmin fragmentation is implicated in 'free' copper deregulation of Alzheimer's disease
    Rosanna Squitti
    AFaR, Department of Neuroscience, Fatebenefratelli Hospital, Isola Tiberina, Rome, Italy
    Prion 2:23-7. 2008
    ..029). Our data indicate a ceruloplasmin fragmentation in the serum of AD patients, possibly related to 'free' copper deregulation in this disease...
  14. doi Longitudinal prognostic value of serum "free" copper in patients with Alzheimer disease
    R Squitti
    Department of Neuroscience, AFaR Osp Fatebenefratelli, 00186, Rome, Italy
    Neurology 72:50-5. 2009
    ..Serum copper not bound to ceruloplasmin ("free") appears slightly elevated in patients with Alzheimer disease (AD). We explored whether a deregulation of the free copper pool can predict AD clinical worsening...
  15. ncbi 'Free' copper in serum of Alzheimer's disease patients correlates with markers of liver function
    R Squitti
    Department of Neuroscience, AFaR Ospedale Fatebenefratelli, Rome, Italy
    J Neural Transm 114:1589-94. 2007
    ..43, p = 0.004), and positively with direct bilirubin. Copper and 'free' copper were higher in the APOE4 carriers. These results suggest that abnormalities in copper metabolism might have an effect on liver function in AD...
  16. doi Free copper distinguishes mild cognitive impairment subjects from healthy elderly individuals
    Rosanna Squitti
    Department of Neuroscience, AFaR Osp Fatebenefratelli, Isola Tiberina, Rome, Italy
    J Alzheimers Dis 23:239-48. 2011
    ..APOE4 and free copper appeared associated to MMSE worsening, as did age and gender. These results suggest that free copper can help in discriminating MCI subjects from healthy controls, but not on an individual basis...
  17. ncbi Elevation of serum copper levels in Alzheimer's disease
    R Squitti
    Department of Neuroscience, AFaR Ospedale Fatebenefratelli, 00186, Rome, Italy
    Neurology 59:1153-61. 2002
    ..To determine whether serum trace metals and oxidative species are related to abnormal cognition in AD...
  18. ncbi Elevation of serum copper levels discriminates Alzheimer's disease from vascular dementia
    R Squitti
    Department of Neuroscience, AFaR Ospedale Fatebenefratelli, Rome, Italy
    Neurology 60:2013-4. 2003
  19. ncbi d-penicillamine reduces serum oxidative stress in Alzheimer's disease patients
    R Squitti
    AFaR, Ospedale Fatebenefratelli, Rome, Italy
    Eur J Clin Invest 32:51-9. 2002
    ..Here, we present a pilot study examining the efficacy of the copper-chelating agent d-penicillamine in reducing oxidative stress in AD patients...
  20. ncbi What is the relationship among atherosclerosis markers, apolipoprotein E polymorphism and dementia?
    C Altamura
    Department of Neuroscience, Università Campus Bio Medico, Rome, Italy
    Eur J Neurol 14:679-82. 2007
    ..The epsilon4 APOE allele may promote intima-media thickening, interacting with other factors contributing to AD development...
  21. ncbi Homocysteine and electroencephalographic rhythms in Alzheimer disease: a multicentric study
    C Babiloni
    Dipartimento di Fisiologia Umana e Farmacologia, Universita degli Studi di Roma La Sapienza, Rome, Italy
    Neuroscience 145:942-54. 2007
    ....
  22. ncbi Inflammation and iron metabolism in adult patients with epilepsy: does a link exist?
    M Tombini
    Neurology, Campus Bio Medico University, Rome, Italy Electronic address
    Epilepsy Res 107:244-52. 2013
    ..Inflammation has been shown to play a key role in epilepsy, and may also affect both the iron status and metabolism. Consequently, a relationship between iron metabolism and neuronal excitability and seizures could be expected...
  23. ncbi Age dependence of primary motor cortex plasticity induced by paired associative stimulation
    F Tecchio
    ISTC CNR, Franca Tecchio, Unità MEG, Fatebenefratelli Hospital, Isola Tiberina, 00186 Roma, Italy Casa di Cura San Raffaele Cassino e IRCCS San Raffaele Pisana, Italy
    Clin Neurophysiol 119:675-82. 2008
    ..Aim of the present study was to characterize LTP-like plasticity dependence on age and gender...
  24. ncbi Understanding the implications of the PAX9 gene in tooth development
    C Arcuri
    Department of Dentistry, University of Rome Tor Vergata, Rome, Italy
    Eur J Paediatr Dent 12:245-8. 2011
    ..Tooth agenesis is characterised by the congenital absence of one or more teeth. The Pax9 gene has been associated with nonsyndromic forms...
  25. ncbi Alteration of peripheral markers of copper homeostasis in Alzheimer's disease patients: implications in aetiology and therapy
    L Rossi
    Department of Biology Tor Vergata University of Rome, Via della Ricerca Scientifica, 00133 Rome, Italy
    J Nutr Health Aging 11:408-17. 2007
    ....
  26. ncbi [Metals and oxidative stress in Parkinson's disease from industrial areas with exposition to environmental toxins or metal pollution]
    R Squitti
    Dipartimento di Neuroscienze, AFaR FBF Ospedale Fatebenefratelli, Italia
    G Ital Med Lav Ergon 29:294-6. 2007
    ..PD is a complex disease, in which and environmental factors, as exposure to toxins or metals coul be involved...