Savino Bruno

Summary

Affiliation: Fatebenefratelli e Oftalmico Hospital
Country: Italy

Publications

  1. doi request reprint Futility of antiviral treatments for hepatitis C: an evolving concept entering the direct antiviral agents era
    Savino Bruno
    A O Fatebenefratelli e Oftalmico, Milan, Italy
    Dig Liver Dis 45:356-61. 2013
  2. doi request reprint Efficacy and safety of boceprevir plus peginterferon-ribavirin in patients with HCV G1 infection and advanced fibrosis/cirrhosis
    Savino Bruno
    Department of Internal Medicine, AO Fatebenefratelli e Oftalmico, Milan, Italy
    J Hepatol 58:479-87. 2013
  3. ncbi request reprint Hepatitis C virus genotype 1b as a major risk factor associated with hepatocellular carcinoma in patients with cirrhosis: a seventeen-year prospective cohort study
    Savino Bruno
    Liver Unit, Department of Medicine, Azienda Ospedaliera Fatebenefratelli e Oftalmico, Milan, Italy
    Hepatology 46:1350-6. 2007
  4. doi request reprint Efficacy and safety of peginterferon alfa-2a (40KD) plus ribavirin in hepatitis C patients with advanced fibrosis and cirrhosis
    Savino Bruno
    AO Fatebenefratelli e Oftalmico, Milan, Italy
    Hepatology 51:388-97. 2010
  5. doi request reprint Predicting mortality risk in patients with compensated HCV-induced cirrhosis: a long-term prospective study
    Savino Bruno
    Department of Internal Medicine, AO Fatebenefratelli e Oftalmico, Milan, Italy
    Am J Gastroenterol 104:1147-58. 2009
  6. pmc Incidence and risk factors for non-alcoholic steatohepatitis: prospective study of 5408 women enrolled in Italian tamoxifen chemoprevention trial
    Savino Bruno
    Liver Unit, Azienda Ospedaliera Fatebenefratelli e Oftalmico, Corso di Porta Nuova 23, 20121 Milan, Italy
    BMJ 330:932. 2005
  7. doi request reprint Sustained virologic response prevents the development of esophageal varices in compensated, Child-Pugh class A hepatitis C virus-induced cirrhosis. A 12-year prospective follow-up study
    Savino Bruno
    Department of Internal Medicine, A O Fatebenefratelli e Oftalmico, Milan, Italy
    Hepatology 51:2069-76. 2010
  8. ncbi request reprint The natural course of HCV infection and the need for treatment
    Savino Bruno
    Department of Internal Medicine, Liver Unit, Azienda Ospedaliera Fatebenefratelli e Oftalmico, Milano, Italy
    Ann Hepatol 7:114-9. 2008
  9. doi request reprint Unusual B cell morphology in inflammatory bowel disease
    Caterina Defendenti
    Laboratory Unit, Fatebenefratelli Hospital, Milan, Italy
    Pathol Res Pract 208:387-91. 2012
  10. doi request reprint Recurrent hepatocellular carcinoma successfully treated with laparoscopic thermal ablation
    Roberto Santambrogio
    UOC di Chirurgia 2, A O San Paolo, Dipartimento di Medicina, Chirurgia ed Odontoiatria, Universita degli Studi di Milano, Via A Di Rudini 8, 20142, Milan, Italy
    Surg Endosc 26:1108-15. 2012

Detail Information

Publications30

  1. doi request reprint Futility of antiviral treatments for hepatitis C: an evolving concept entering the direct antiviral agents era
    Savino Bruno
    A O Fatebenefratelli e Oftalmico, Milan, Italy
    Dig Liver Dis 45:356-61. 2013
    ....
  2. doi request reprint Efficacy and safety of boceprevir plus peginterferon-ribavirin in patients with HCV G1 infection and advanced fibrosis/cirrhosis
    Savino Bruno
    Department of Internal Medicine, AO Fatebenefratelli e Oftalmico, Milan, Italy
    J Hepatol 58:479-87. 2013
    ..We assessed the safety and efficacy of boceprevir (BOC) plus peginterferon-ribavirin (PR) in patients with HCV-G1 infection and advanced fibrosis/cirrhosis (Metavir F3/F4)...
  3. ncbi request reprint Hepatitis C virus genotype 1b as a major risk factor associated with hepatocellular carcinoma in patients with cirrhosis: a seventeen-year prospective cohort study
    Savino Bruno
    Liver Unit, Department of Medicine, Azienda Ospedaliera Fatebenefratelli e Oftalmico, Milan, Italy
    Hepatology 46:1350-6. 2007
    ..Patients with cirrhosis that are infected with this genotype require more intensive surveillance for the early detection and aggressive management of neoplasia...
  4. doi request reprint Efficacy and safety of peginterferon alfa-2a (40KD) plus ribavirin in hepatitis C patients with advanced fibrosis and cirrhosis
    Savino Bruno
    AO Fatebenefratelli e Oftalmico, Milan, Italy
    Hepatology 51:388-97. 2010
    ..However, irrespective of genotype and degree of fibrosis, the time to become hepatitis C virus (HCV) RNA undetectable was the strongest predictor of SVR...
  5. doi request reprint Predicting mortality risk in patients with compensated HCV-induced cirrhosis: a long-term prospective study
    Savino Bruno
    Department of Internal Medicine, AO Fatebenefratelli e Oftalmico, Milan, Italy
    Am J Gastroenterol 104:1147-58. 2009
    ..The identification of prognostic factors associated with mortality is crucial in any clinical setting...
  6. pmc Incidence and risk factors for non-alcoholic steatohepatitis: prospective study of 5408 women enrolled in Italian tamoxifen chemoprevention trial
    Savino Bruno
    Liver Unit, Azienda Ospedaliera Fatebenefratelli e Oftalmico, Corso di Porta Nuova 23, 20121 Milan, Italy
    BMJ 330:932. 2005
    ..To assess the incidence, cofactors, and excess risk of development of non-alcoholic fatty liver disease, including non-alcoholic steatohepatitis, attributable to tamoxifen in women...
  7. doi request reprint Sustained virologic response prevents the development of esophageal varices in compensated, Child-Pugh class A hepatitis C virus-induced cirrhosis. A 12-year prospective follow-up study
    Savino Bruno
    Department of Internal Medicine, A O Fatebenefratelli e Oftalmico, Milan, Italy
    Hepatology 51:2069-76. 2010
    ..40; 95% confidence interval [CI] 1.17-4.90) and baseline model for end-stage liver disease (MELD) score (HR 1.20; 95% CI 1.07-1.35 for 1 point increase) were independent predictors of EV...
  8. ncbi request reprint The natural course of HCV infection and the need for treatment
    Savino Bruno
    Department of Internal Medicine, Liver Unit, Azienda Ospedaliera Fatebenefratelli e Oftalmico, Milano, Italy
    Ann Hepatol 7:114-9. 2008
    ....
  9. doi request reprint Unusual B cell morphology in inflammatory bowel disease
    Caterina Defendenti
    Laboratory Unit, Fatebenefratelli Hospital, Milan, Italy
    Pathol Res Pract 208:387-91. 2012
    ....
  10. doi request reprint Recurrent hepatocellular carcinoma successfully treated with laparoscopic thermal ablation
    Roberto Santambrogio
    UOC di Chirurgia 2, A O San Paolo, Dipartimento di Medicina, Chirurgia ed Odontoiatria, Universita degli Studi di Milano, Via A Di Rudini 8, 20142, Milan, Italy
    Surg Endosc 26:1108-15. 2012
    ..Aggressive treatment of intrahepatic recurrence of hepatocellular carcinoma (HCC) increases patients' survival. This study aimed to evaluate laparoscopic thermal ablation (TA) in the treatment of intrahepatic HCC recurrences...
  11. ncbi request reprint Sustained virological response to interferon-alpha is associated with improved outcome in HCV-related cirrhosis: a retrospective study
    Savino Bruno
    Liver Unit, Department of Medicine, AO Fatebenefratelli e Oftalmico, Milan, Italy
    Hepatology 45:579-87. 2007
    ..Irrespective of SVR achievement, all patients should continue surveillance because the risk of occurrence of HCC was not entirely avoided...
  12. ncbi request reprint Pegylated interferon-alpha2b plus ribavirin: an efficacious and well-tolerated treatment regimen for patients with hepatitis C virus related histologically proven cirrhosis
    Luigi Roffi
    Department of Internal Medicine, Azienda Ospedaliera della Valtellina e della Valchiavenna, Sondrio, Italy
    Antivir Ther 13:663-73. 2008
    ..We aimed here to evaluate the safety of this regimen in such patients and to identify baseline and on-treatment predictors of a sustained virological response (SVR)...
  13. pmc Morphological distribution of μ chains and cd15 receptors in colorectal polyp and adenocarcinoma specimens
    Caterina Defendenti
    Laboratory Unit and Divisions of Fatebenefratelli Hospital, Milan, Italy
    BMC Clin Pathol 13:8. 2013
    ..The aim of the study was to analyse variations in IPCs and CD15+ cell morphology or distribution in bowel biopsy specimens taken from patients with pre-malignant polyps or adenocarcinomas...
  14. doi request reprint Is response to antiviral treatment influenced by hepatitis B virus genotype?
    Sara Raimondi
    Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy
    J Hepatol 52:441-9. 2010
    ....
  15. pmc B lymphocyte intestinal homing in inflammatory bowel disease
    Caterina Defendenti
    Laboratory Unit, Fatebenefratelli Hospital, Milan, Italy
    BMC Immunol 12:71. 2011
    ..The objective is to investigate the localisation of immunoglobulin-producing cells (IPCs) in samples of inflamed intestinal tissue taken from patients with IBD, and their possible relationship with clinical features...
  16. doi request reprint Recommendations for the management of mixed cryoglobulinemia syndrome in hepatitis C virus-infected patients
    Maurizio Pietrogrande
    Medicina Interna, Department of Medicine, Surgery and Dentistry, Policlinico San Marco of Zingonia, University of Milan, Italy
    Autoimmun Rev 10:444-54. 2011
    ..The objective of this review was to define a core set of recommendations for the treatment of HCV-associated mixed cryoglobulinemia syndrome (MCS) by combining current evidence from clinical trials and expert opinion...
  17. ncbi request reprint Peginterferon alfa-2b plus ribavirin for naïve patients with genotype 1 chronic hepatitis C: a randomized controlled trial
    Savino Bruno
    Clinica Medica, Ospedale San Paolo and Liver Unit, Ospedale Fatebenefratelli e Oftalmico, Milano, Italy
    J Hepatol 41:474-81. 2004
    ..We assessed the effectiveness and safety of an induction dose of peginterferon alfa-2b (PEG-IFN) plus ribavirin for initial treatment of patients with genotype 1 chronic HCV infection in a randomized, controlled, multicenter trial...
  18. ncbi request reprint [Anti-PR3 positive inflammatory bowel disease. Description of a case]
    Caterina Defendenti
    Laboratorio Analisi, Ospedale Fatebenefratelli, Milano
    Recenti Prog Med 100:253-6. 2009
    ..The patient was exposed to two different bacteria: salmonellosis was reported in patient history, while Staphylococcus aureus infection was diagnosed during the present hospital stay. Antibiotics and steroids are effective...
  19. doi request reprint Assessment of anti-prothrombin antibodies in thrombosis complicating inflammatory bowel diseases
    Simone Saibeni
    Unit of Internal Medicine and Hepatology, Azienda Ospedaliera Fatebenefratelli and Oftalmico, Milan, Italy
    Int J Colorectal Dis 28:1281-6. 2013
    ..The aim of the study is to evaluate the prevalence of aPT antibodies in IBD patients, with and without thrombosis...
  20. doi request reprint The use of methotrexate for treatment of inflammatory bowel disease in clinical practice
    Simone Saibeni
    Azienda Ospedaliera Fatebenefratelli e Oftalmico, Milan, Italy
    Dig Liver Dis 44:123-7. 2012
    ..Methotrexate is considered a treatment for Crohn's disease, whilst few data in ulcerative colitis are available...
  21. doi request reprint Hepatic resection for "BCLC stage A" hepatocellular carcinoma. The prognostic role of alpha-fetoprotein
    Roberto Santambrogio
    UOC di Chirurgia 2 Chirurgia Epato bilio pancreatica e Digestiva, A O San Paolo, Dipartimento di Medicina, Chirurgia ed Odontoiatria, Universita degli Studi di Milano, Milan, Italy
    Ann Surg Oncol 19:426-34. 2012
    ..Our aim was to assess the capability of Barcelona Clinic Liver Cancer (BCLC) staging system in allocating stage A patients to hepatic resection (HR) and the effect on survival...
  22. doi request reprint Liver stiffness, a non-invasive marker of liver disease: a core study group report
    Ferruccio Bonino
    Digestive and Liver Disease Unit, Department of Internal Medicine, University of Pisa, Pisa, Italy
    Antivir Ther 15:69-78. 2010
    ..The group concluded that FibroScan(®) is a valuable, non-invasive technique and have developed a consensus report form for registering transient elastography results. In this article, we report the findings of the study group...
  23. doi request reprint Mortality risk according to different clinical characteristics of first episode of liver decompensation in cirrhotic patients: a nationwide, prospective, 3-year follow-up study in Italy
    Savino Bruno
    Dipartimento di Medicina Interna, A O Fatebenefratelli e Oftalmico, Milano, Italy
    Am J Gastroenterol 108:1112-22. 2013
    ..The purpose of this study was to assess the risk of mortality according to the clinical characteristics of first decompensation, considering also the impact of acute-on-chronic liver failure (AoCLF)...
  24. doi request reprint Increased thrombin generation in inflammatory bowel diseases
    Simone Saibeni
    Department of Internal Medicine and Hepatology, Azienda Ospedaliera Fatebenefratelli e Oftalmico, Milan, Italy
    Thromb Res 125:278-82. 2010
    ..Endogenous thrombin potential (ETP), a parameter of the thrombin generation curve, represents a new tool in the evaluation of thrombotic and bleeding disorders...
  25. doi request reprint Lack of correlation between serum anti-HBcore detectability and hepatocellular carcinoma in patients with HCV-related cirrhosis
    Tommaso Stroffolini
    Department of Gastroenterology, Ospedale San Giacomo, Roma, Italy
    Am J Gastroenterol 103:1966-72. 2008
    ....
  26. ncbi request reprint Insulin resistance is associated with steatosis in nondiabetic patients with genotype 1 chronic hepatitis C
    Calogero Cammà
    Unità Operativa di Gastroenterologia, University of Palermo, Italy
    Hepatology 43:64-71. 2006
    ..IR is a risk factor for moderate/severe steatosis, especially in men. Moderate/severe steatosis has clinical relevance, being associated with advanced fibrosis and hyporesponsiveness to antiviral therapy...
  27. ncbi request reprint Sustained response to combination therapy in patients with chronic hepatitis C who failed to respond to interferon
    Silvia Fargion
    Dipartimento di Medicina Interna, Ospedale Maggiore IRCCS, Universita di Milano, Pad Granelli, Via F Sforza 35, 20122 Milan, Italy
    J Hepatol 38:499-505. 2003
    ..The best treatment for chronic hepatitis C patients who do not respond to interferon is still unknown. Reported rates of response to treatment vary as the result of heterogeneous definitions of non-responders and small study size...
  28. ncbi request reprint A 15-Yr Prospective Histological Follow-Up Study in Patients With Persistently Normal Aminotransferase Levels (PNAL) Carrying HCV Infection
    Sonia Rossi
    Am J Gastroenterol 102:2604-6. 2007
  29. ncbi request reprint Natural history of a randomized trial comparing distal spleno-renal shunt with endoscopic sclerotherapy in the prevention of variceal rebleeding: a lesson from the past
    Roberto Santambrogio
    Unità di Chirurgia Bilio pancreatica, Azienda Ospedaliera San Paolo Università degli Studi di Milano, Italy
    World J Gastroenterol 12:6331-8. 2006
    ..To compare endoscopic sclerotherapy (ES) with distal splenorenal shunt (DSRS) in the prevention of recurrent variceal bleeding in cirrhotic patients during a long-term follow-up period...
  30. ncbi request reprint Interleukin-10 - 1082 GG polymorphism influences the occurrence and the clinical characteristics of hepatitis C virus infection
    Marcello Persico
    Cattedra di Medicina Interna, Seconda Universita di Napoli, Italy
    J Hepatol 45:779-85. 2006
    ....