Affiliation: Experimental Pharmacology Unit
Pignata S, De Placido S, Biamonte R, Scambia G, Di Vagno G, Colucci G, et al
. Residual neurotoxicity in ovarian cancer patients in clinical remission after first-line chemotherapy with carboplatin and paclitaxel: the Multicenter Italian Trial in Ovarian cancer (MITO-4) retrospective study. BMC Cancer. 2006;6:5 pubmed
..This issue should be carefully taken into account before considering re-treatment with the same agents in sensitive recurrent disease. ..
Pignata S, Scambia G, Savarese A, Breda E, Scollo P, De Vivo R, et al
. Safety of a 3-weekly schedule of carboplatin plus pegylated liposomal doxorubicin as first line chemotherapy in patients with ovarian cancer: preliminary results of the MITO-2 randomized trial. BMC Cancer. 2006;6:202 pubmed
..Toxicities that are common with standard combination of carboplatin plus paclitaxel (neurotoxicity and hair loss) are infrequent with this experimental schedule, and skin toxicity appears manageable. ..
Pignata S, Scambia G, Pisano C, Breda E, Di Maio M, Greggi S, et al
. A multicentre phase II study of carboplatin plus pegylated liposomal doxorubicin as first-line chemotherapy for patients with advanced or recurrent endometrial carcinoma: the END-1 study of the MITO (Multicentre Italian Trials in Ovarian Cancer and G. Br J Cancer. 2007;96:1639-43 pubmed
..Hair loss: complete 5%, partial 12%. The combination of carboplatin and PLD shows good activity and favourable toxicity as first-line chemotherapy of patients with AEC, deserving further studies in this setting. ..
Pignata S, Ferrandina G, Scarfone G, Scollo P, Odicino F, Selvaggi L, et al
. Extending the platinum-free interval with a non-platinum therapy in platinum-sensitive recurrent ovarian cancer. Results from the SOCRATES Retrospective Study. Oncology. 2006;71:320-6 pubmed
Pignata S, Scambia G, Savarese A, Breda E, Sorio R, Pisano C, et al
. Carboplatin and pegylated liposomal doxorubicin for advanced ovarian cancer: preliminary activity results of the MITO-2 phase III trial. Oncology. 2009;76:49-54 pubmed publisher
..Stable disease was reported in an additional 10 patients (20%). The adopted schedule of PLD plus carboplatin demonstrates activity as a first-line treatment for advanced ovarian cancer. ..
Pignata S, Ferrandina G, Scarfone G, Scollo P, Odicino F, Cormio G, et al
. Activity of chemotherapy in mucinous ovarian cancer with a recurrence free interval of more than 6 months: results from the SOCRATES retrospective study. BMC Cancer. 2008;8:252 pubmed publisher
..The aim of this study was to evaluate, retrospectively, the activity of chemotherapy in patients with platinum sensitive recurrent mucinous ovarian cancer...