Walter Witke

Summary

Affiliation: European Molecular Biology Laboratory
Country: Italy

Publications

  1. ncbi request reprint The role of profilin complexes in cell motility and other cellular processes
    Walter Witke
    EMBL, Program for Mouse Biology, Campus Adriano Buzzati Traverso, 00016 Monterotondo, Italy
    Trends Cell Biol 14:461-9. 2004
  2. ncbi request reprint HuGE, a novel GFP-actin-expressing mouse line for studying cytoskeletal dynamics
    Christine B Gurniak
    EMBL Mouse Biology Unit, Campus Adriano Buzzati Traverso, Via Ramarini 32, I 00016 Monterotondo, Italy
    Eur J Cell Biol 86:3-12. 2007
  3. pmc Profilin2 contributes to synaptic vesicle exocytosis, neuronal excitability, and novelty-seeking behavior
    Pietro Pilo Boyl
    EMBL, Mouse Biology Unit, Adriano Buzzati Traverso Campus, Via Ramarini 32, 00015 Monterotondo, Italy
    EMBO J 26:2991-3002. 2007
  4. ncbi request reprint Mouse profilin 2 regulates endocytosis and competes with SH3 ligand binding to dynamin 1
    Ralph Gareus
    Mouse Biology Unit, European Molecular Biology Laboratory EMBL, Campus Adriano Buzzati Traverso, 00016 Monterotondo, Italy
    J Biol Chem 281:2803-11. 2006
  5. ncbi request reprint The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migration
    Christine B Gurniak
    European Molecular Biology Laboratory, Mouse Biology Programme, Adriano Buzzati Traverso Campus, Via Ramarini 32, 00016 Monterotondo, Italy
    Dev Biol 278:231-41. 2005
  6. ncbi request reprint High-resolution structural analysis of mammalian profilin 2a complex formation with two physiological ligands: the formin homology 1 domain of mDia1 and the proline-rich domain of VASP
    Petri Kursula
    EMBL Hamburg Outstation, DESY, Notkestrasse 85, D 22607 Hamburg, Germany
    J Mol Biol 375:270-90. 2008
  7. pmc RhoA/ROCK regulation of neuritogenesis via profilin IIa-mediated control of actin stability
    Jorge Santos Da Silva
    Cavalieri Ottolenghi Scientific Institute, University of Turin, 10043 Orbassano, Torino, Italy
    J Cell Biol 162:1267-79. 2003
  8. ncbi request reprint The actin-binding protein profilin I is localized at synaptic sites in an activity-regulated manner
    Henrike Neuhoff
    Zentrum fur Molekulare Neurobiologie Hamburg, ZMNH, University of Hamburg, Falkenried 94, D 20251 Hamburg, Germany
    Eur J Neurosci 21:15-25. 2005
  9. pmc N-cofilin is associated with neuronal migration disorders and cell cycle control in the cerebral cortex
    Gian Carlo Bellenchi
    Mouse Biology Unit, European Molecular Biology Laboratory EMBL, 00015, Monterotondo, Italy
    Genes Dev 21:2347-57. 2007

Collaborators

  • Matthias Kneussel
  • Marco Sasso√®-Pognetto
  • P Kursula
  • Will A Stanley
  • Christine B Gurniak
  • Emerald Perlas
  • Alessia Di Nardo
  • Pietro Pilo Boyl
  • Gian Carlo Bellenchi
  • Patrizia Panzanelli
  • Ralph Gareus
  • Henrike Neuhoff
  • Jorge Santos Da Silva
  • Vivian Costantini
  • Christophe Mulle
  • Martine Ammassari-Teule
  • Maurizio Giustetto
  • Hugo Vara
  • Marzia Massimi
  • Silvia Middei
  • Andrea Mele
  • Vladimir Rybin
  • Christoph Maas
  • Carlos G Dotti
  • Cecilia Zuliani
  • Miguel Medina

Detail Information

Publications9

  1. ncbi request reprint The role of profilin complexes in cell motility and other cellular processes
    Walter Witke
    EMBL, Program for Mouse Biology, Campus Adriano Buzzati Traverso, 00016 Monterotondo, Italy
    Trends Cell Biol 14:461-9. 2004
    ....
  2. ncbi request reprint HuGE, a novel GFP-actin-expressing mouse line for studying cytoskeletal dynamics
    Christine B Gurniak
    EMBL Mouse Biology Unit, Campus Adriano Buzzati Traverso, Via Ramarini 32, I 00016 Monterotondo, Italy
    Eur J Cell Biol 86:3-12. 2007
    ..Therefore, the huGE mouse line provides a novel tool to monitor actin dynamics in mouse embryos and a wide range of organs...
  3. pmc Profilin2 contributes to synaptic vesicle exocytosis, neuronal excitability, and novelty-seeking behavior
    Pietro Pilo Boyl
    EMBL, Mouse Biology Unit, Adriano Buzzati Traverso Campus, Via Ramarini 32, 00015 Monterotondo, Italy
    EMBO J 26:2991-3002. 2007
    ..Our results highlight a novel, profilin2-dependent pathway, regulating synaptic physiology, neuronal excitability, and complex behavior...
  4. ncbi request reprint Mouse profilin 2 regulates endocytosis and competes with SH3 ligand binding to dynamin 1
    Ralph Gareus
    Mouse Biology Unit, European Molecular Biology Laboratory EMBL, Campus Adriano Buzzati Traverso, 00016 Monterotondo, Italy
    J Biol Chem 281:2803-11. 2006
    ....
  5. ncbi request reprint The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migration
    Christine B Gurniak
    European Molecular Biology Laboratory, Mouse Biology Programme, Adriano Buzzati Traverso Campus, Via Ramarini 32, 00016 Monterotondo, Italy
    Dev Biol 278:231-41. 2005
    ..Our data suggest that in mammalian development, regulation of the actin cytoskeleton by the F-actin depolymerizing factor n-cofilin is critical for epithelial-mesenchymal type of cell shape changes as well as cell proliferation...
  6. ncbi request reprint High-resolution structural analysis of mammalian profilin 2a complex formation with two physiological ligands: the formin homology 1 domain of mDia1 and the proline-rich domain of VASP
    Petri Kursula
    EMBL Hamburg Outstation, DESY, Notkestrasse 85, D 22607 Hamburg, Germany
    J Mol Biol 375:270-90. 2008
    ..Our data provide structural insights into the mechanisms of mDia1 and VASP regulated actin polymerisation...
  7. pmc RhoA/ROCK regulation of neuritogenesis via profilin IIa-mediated control of actin stability
    Jorge Santos Da Silva
    Cavalieri Ottolenghi Scientific Institute, University of Turin, 10043 Orbassano, Torino, Italy
    J Cell Biol 162:1267-79. 2003
    ..We propose that RhoA/ROCK/PIIa-mediated regulation of actin stability, shown to be essential for neuritogenesis, may constitute a central mechanism throughout neuronal differentiation...
  8. ncbi request reprint The actin-binding protein profilin I is localized at synaptic sites in an activity-regulated manner
    Henrike Neuhoff
    Zentrum fur Molekulare Neurobiologie Hamburg, ZMNH, University of Hamburg, Falkenried 94, D 20251 Hamburg, Germany
    Eur J Neurosci 21:15-25. 2005
    ..These results show that profilin I can be present at both pre- and postsynaptic sites and suggest a role for this actin-binding protein in activity-dependent remodelling of synaptic structure...
  9. pmc N-cofilin is associated with neuronal migration disorders and cell cycle control in the cerebral cortex
    Gian Carlo Bellenchi
    Mouse Biology Unit, European Molecular Biology Laboratory EMBL, 00015, Monterotondo, Italy
    Genes Dev 21:2347-57. 2007
    ..These results demonstrate that mutations affecting regulators of the actin cytoskeleton contribute to the pathology of cortex development...