Andrea Viale

Summary

Affiliation: European Institute of Oncology
Country: Italy

Publications

  1. doi Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells
    Andrea Viale
    Department of Experimental Oncology at the IFOM IEO Campus, European Institute of Oncology, IEO, 20141 Milan, Italy
    Nature 457:51-6. 2009
  2. pmc Awaking stem cells from dormancy: growing old and fighting cancer
    Andrea Viale
    European Institute of Oncology at the IFOM IEO Campus, Milan, Italy
    EMBO Mol Med 1:88-91. 2009
  3. pmc DNA damage in stem cells activates p21, inhibits p53, and induces symmetric self-renewing divisions
    Alessandra Insinga
    Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy
    Proc Natl Acad Sci U S A 110:3931-6. 2013
  4. pmc Spontaneous cell fusion of acute leukemia cells and macrophages observed in cells with leukemic potential
    Ines Martin-Padura
    Laboratory of Hematology Oncology, European Institute of Oncology, Milan, Italy
    Neoplasia 14:1057-66. 2012
  5. ncbi Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway
    Alessandra Insinga
    Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Nat Med 11:71-6. 2005

Collaborators

Detail Information

Publications5

  1. doi Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells
    Andrea Viale
    Department of Experimental Oncology at the IFOM IEO Campus, European Institute of Oncology, IEO, 20141 Milan, Italy
    Nature 457:51-6. 2009
    ..These data unravel the oncogenic potential of p21 and suggest that inhibition of DNA repair mechanisms might function as potent strategy for the eradication of the slowly proliferating leukaemia stem cells...
  2. pmc Awaking stem cells from dormancy: growing old and fighting cancer
    Andrea Viale
    European Institute of Oncology at the IFOM IEO Campus, Milan, Italy
    EMBO Mol Med 1:88-91. 2009
    ..As regards hematopoietic stem cells (HSC), their resistance to antiproliferative drugs supports this notion. Maintenance of quiescence is thought to be critical for the preservation of HSCs' function...
  3. pmc DNA damage in stem cells activates p21, inhibits p53, and induces symmetric self-renewing divisions
    Alessandra Insinga
    Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy
    Proc Natl Acad Sci U S A 110:3931-6. 2013
    ..These findings suggest that stem cells have evolved a unique, p21-dependent response to DNA damage that leads to their immediate expansion and limits their long-term survival...
  4. pmc Spontaneous cell fusion of acute leukemia cells and macrophages observed in cells with leukemic potential
    Ines Martin-Padura
    Laboratory of Hematology Oncology, European Institute of Oncology, Milan, Italy
    Neoplasia 14:1057-66. 2012
    ....
  5. ncbi Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway
    Alessandra Insinga
    Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Nat Med 11:71-6. 2005
    ..These results show that sensitivity to HDACIs in leukemias is a property of the fully transformed phenotype and depends on activation of a specific death pathway...