Umberto Veronesi

Summary

Affiliation: European Institute of Oncology
Country: Italy

Publications

  1. doi request reprint Unavoidable mastectomy for ipsilateral breast tumour recurrence after conservative surgery: patient outcome
    E Botteri
    Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy
    Ann Oncol 20:1008-12. 2009
  2. ncbi request reprint Chemoprevention of breast cancer with fenretinide (4-HPR): study of long-term visual and ophthalmologic tolerability
    L Mariani
    Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Tumori 82:444-9. 1996
  3. ncbi request reprint Radiation survey around a Liac mobile electron linear accelerator for intraoperative radiation therapy
    Mario Ciocca
    Unit of Medical Physics, European Institute of Oncology, Via Ripamonti 435, 20141 Milano, Italy
    J Appl Clin Med Phys 10:2950. 2009
  4. doi request reprint Ductal intraepithelial neoplasia: postsurgical outcome for 1,267 women cared for in one single institution over 10 years
    Aliana Guerrieri-Gonzaga
    Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy
    Oncologist 14:201-12. 2009
  5. doi request reprint Axillary metastases in breast cancer patients with negative sentinel nodes: a follow-up of 3548 cases
    Umberto Veronesi
    Scientific Director European Institute of Oncology, Via G Ripamonti 435, I 20141 Milan, Italy
    Eur J Cancer 45:1381-8. 2009
  6. doi request reprint Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): a randomised controlled equivalence trial
    Umberto Veronesi
    Scientific Directorate, European Institute of Oncology, Milan, Italy Electronic address
    Lancet Oncol 14:1269-77. 2013
  7. doi request reprint Conservative mastectomy: extending the idea of breast conservation
    Umberto Veronesi
    Scientific Direction, European Institute of Oncology, Milan, Italy
    Lancet Oncol 13:e311-7. 2012
  8. doi request reprint Rethinking TNM: a breast cancer classification to guide to treatment and facilitate research
    Umberto Veronesi
    Scientific Director European Institute of Oncology, Milan, Italy
    Breast J 15:291-5. 2009
  9. ncbi request reprint Fifteen-year results of a randomized phase III trial of fenretinide to prevent second breast cancer
    U Veronesi
    European Institute of Oncology, Milan, Italy
    Ann Oncol 17:1065-71. 2006
  10. ncbi request reprint Radiotherapy after breast-conserving surgery in small breast carcinoma: long-term results of a randomized trial
    U Veronesi
    Department of Senology, European Institute of Oncology, Milano, Italy
    Ann Oncol 12:997-1003. 2001

Detail Information

Publications132 found, 100 shown here

  1. doi request reprint Unavoidable mastectomy for ipsilateral breast tumour recurrence after conservative surgery: patient outcome
    E Botteri
    Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy
    Ann Oncol 20:1008-12. 2009
    ..In the case of ipsilateral breast tumour recurrence (IBTR) after breast-conserving surgery (BCS), a second conservative surgical approach maybe considered in some motivated patients whereas in others mastectomy is unavoidable...
  2. ncbi request reprint Chemoprevention of breast cancer with fenretinide (4-HPR): study of long-term visual and ophthalmologic tolerability
    L Mariani
    Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Tumori 82:444-9. 1996
    ..However, the pattern of occurrence over time and the underlying mechanisms of these two types of complaints seem different...
  3. ncbi request reprint Radiation survey around a Liac mobile electron linear accelerator for intraoperative radiation therapy
    Mario Ciocca
    Unit of Medical Physics, European Institute of Oncology, Via Ripamonti 435, 20141 Milano, Italy
    J Appl Clin Med Phys 10:2950. 2009
    ..Our data can be useful for centers planning to implement an IORT program using a mobile linear accelerator, permitting radiation safety personnel to estimate in advance the shielding required for a particular workload...
  4. doi request reprint Ductal intraepithelial neoplasia: postsurgical outcome for 1,267 women cared for in one single institution over 10 years
    Aliana Guerrieri-Gonzaga
    Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy
    Oncologist 14:201-12. 2009
    ..We analyzed risk factors and treatment outcome in a large series of women treated at one institution...
  5. doi request reprint Axillary metastases in breast cancer patients with negative sentinel nodes: a follow-up of 3548 cases
    Umberto Veronesi
    Scientific Director European Institute of Oncology, Via G Ripamonti 435, I 20141 Milan, Italy
    Eur J Cancer 45:1381-8. 2009
    ..PREMISES: Sentinel node biopsy (SNB) in patients with breast carcinoma accurately predicts the axillary node status. However, in some 4-7% of patients with negative sentinel nodes, the remaining axillary nodes harbour cancer cells...
  6. doi request reprint Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): a randomised controlled equivalence trial
    Umberto Veronesi
    Scientific Directorate, European Institute of Oncology, Milan, Italy Electronic address
    Lancet Oncol 14:1269-77. 2013
    ..However, its ability to control for recurrence of local disease required confirmation in a randomised controlled trial...
  7. doi request reprint Conservative mastectomy: extending the idea of breast conservation
    Umberto Veronesi
    Scientific Direction, European Institute of Oncology, Milan, Italy
    Lancet Oncol 13:e311-7. 2012
    ..A complication, however infrequent, is nipple necrosis, which can be treated successfully by local excision. Several breast reconstructive techniques are used during conservative mastectomy and aesthetic results are good in most cases...
  8. doi request reprint Rethinking TNM: a breast cancer classification to guide to treatment and facilitate research
    Umberto Veronesi
    Scientific Director European Institute of Oncology, Milan, Italy
    Breast J 15:291-5. 2009
    ....
  9. ncbi request reprint Fifteen-year results of a randomized phase III trial of fenretinide to prevent second breast cancer
    U Veronesi
    European Institute of Oncology, Milan, Italy
    Ann Oncol 17:1065-71. 2006
    ..We conducted a long-term analysis in a subgroup of women who were regularly followed up in a single center...
  10. ncbi request reprint Radiotherapy after breast-conserving surgery in small breast carcinoma: long-term results of a randomized trial
    U Veronesi
    Department of Senology, European Institute of Oncology, Milano, Italy
    Ann Oncol 12:997-1003. 2001
    ..Breast-conserving surgery followed by radiotherapy is a widely accepted form of treatment in patients with breast cancer of limited extent. Many attempts have been made to identify subgroups of patients who might avoid radiotherapy...
  11. ncbi request reprint A preliminary report of intraoperative radiotherapy (IORT) in limited-stage breast cancers that are conservatively treated
    U Veronesi
    Radiotherapy Division, Istituto Europeo di Oncologia, University of Milan, Via G Ripamonti 435, 20141 Milan, Italy
    Eur J Cancer 37:2178-83. 2001
    ..However, a longer follow-up is needed for a better evaluation of the possible late side-effects...
  12. ncbi request reprint A randomized comparison of sentinel-node biopsy with routine axillary dissection in breast cancer
    Umberto Veronesi
    Division of Senology, European Institute of Oncology, Milan, Italy
    N Engl J Med 349:546-53. 2003
    ..Although numerous studies have shown that the status of the sentinel node is an accurate predictor of the status of the axillary nodes in breast cancer, the efficacy and safety of sentinel-node biopsy require validation...
  13. ncbi request reprint Paradigm changes in medical science
    Umberto Veronesi
    European Institute of Oncology Milan, Italy
    Tumori 94:141-2. 2008
  14. ncbi request reprint Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer
    Umberto Veronesi
    Department of Senology, European Institute of Oncology, Milan, Italy
    N Engl J Med 347:1227-32. 2002
    ..We conducted 20 years of follow-up of women enrolled in a randomized trial to compare the efficacy of radical (Halsted) mastectomy with that of breast-conserving surgery...
  15. doi request reprint The value of radiotherapy on metastatic internal mammary nodes in breast cancer. Results on a large series
    U Veronesi
    European Institute of Oncology, Milan, Italy
    Ann Oncol 19:1553-60. 2008
    ..We assume that this excellent result is due to radiotherapy to internal mammary nodes and we propose that exploration of internal mammary nodes should be part of the staging process of carcinomas of the medial part of the breast...
  16. ncbi request reprint Sentinel-lymph-node biopsy as a staging procedure in breast cancer: update of a randomised controlled study
    Umberto Veronesi
    Scientific Direction, European Institute of Oncology, Milan, Italy
    Lancet Oncol 7:983-90. 2006
    ..Results of our previous trial showed that SLNB accurately screens the ALN for metastasis in breast cancers of diameter 2 mm or less. We aimed to update this trial with results from longer follow-up...
  17. ncbi request reprint A comparative study on the value of FDG-PET and sentinel node biopsy to identify occult axillary metastases
    U Veronesi
    Division of Senology, European Institute of Oncology, Milan, Italy
    Ann Oncol 18:473-8. 2007
    ..The aim of this study was to compare SNB and -positron emission tomography (-PET) imaging, to assess their values in detecting occult axillary metastases...
  18. ncbi request reprint Breast conservation: current results and future perspectives at the European Institute of Oncology
    Umberto Veronesi
    Senology Department, European Institute of Oncology, Milan, Italy
    Int J Cancer 120:1381-6. 2007
    ..There are still near horizons to reach: modern neo-adjuvant and adjuvant treatments are going quickly from the laboratory to patient's bed...
  19. ncbi request reprint Tamoxifen for the prevention of breast cancer: late results of the Italian Randomized Tamoxifen Prevention Trial among women with hysterectomy
    Umberto Veronesi
    Scientific Directorate, European Institute of Oncology, Milan, Italy
    J Natl Cancer Inst 99:727-37. 2007
    ..Here we present an extended follow-up of the Italian trial...
  20. ncbi request reprint Full-dose intraoperative radiotherapy with electrons during breast-conserving surgery
    Umberto Veronesi
    Office of the Scientific Director, Milan, Italy
    Arch Surg 138:1253-6. 2003
    ..Intraoperative RT delivered with electrons at the total isodose of 2100 rad (21 Gy) could in principle substitute the currently used radiation course of external RT after breast-conserving surgery in selected cases...
  21. ncbi request reprint Sentinel lymph node biopsy as an indicator for axillary dissection in early breast cancer
    U Veronesi
    Senology Department, Istituto Europeo di Oncologia, Via G Ripamonti 435, I 20141, Milan, Italy
    Eur J Cancer 37:454-8. 2001
    ..These findings provide further confirmation of the validity of SNB and prompt us to suggest that it should become the method of choice for axillary staging in small-sized breast cancer...
  22. ncbi request reprint Rethinking TNM: breast cancer TNM classification for treatment decision-making and research
    Umberto Veronesi
    European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Breast 15:3-8. 2006
    ..The significant changes we propose are:..
  23. ncbi request reprint Chemoprevention: from research to clinical oncology
    Umberto Veronesi
    European Institute of Oncology, Via G Ripamonti, 435, 20141 Milan, Italy
    Eur J Cancer 41:1833-41. 2005
    ..Combination chemoprevention and the use of agents with multiple effects are other particularly promising chemoprevention strategies...
  24. pmc Full-dose intraoperative radiotherapy with electrons during breast-conserving surgery: experience with 590 cases
    Umberto Veronesi
    Istituto Europeo di Oncologia, Division of Radiotherapy, Istituto Europeo di Oncologia, Milan, Italy
    Ann Surg 242:101-6. 2005
    ..The new mobile linear accelerators easily moved close to the operating table to allow the full-dose irradiation during surgery...
  25. ncbi request reprint Breast cancer
    Umberto Veronesi
    European Institute of Oncology, Milan, Italy
    Lancet 365:1727-41. 2005
    ..Assessment of potential molecular targets is now important in primary diagnosis. Tyrosine-kinase inhibitors and other drugs with anti-angiogenesis properties are currently undergoing preclinical investigations...
  26. ncbi request reprint Avoiding axillary dissection in breast cancer surgery: a randomized trial to assess the role of axillary radiotherapy
    U Veronesi
    Division of Senology, European Institute of Oncology, Via G Ripamonti 435, 20141 Milan, Italy
    Ann Oncol 16:383-8. 2005
    ..The aim of the study was to assess the role of axillary radiotherapy (RT) in reducing axillary metastases in patients with early breast cancer who did not receive axillary dissection...
  27. pmc Nonpalpable breast carcinomas: long-term evaluation of 1,258 cases
    Umberto Veronesi
    IEO European Institute of Oncology, Milan, Italy
    Oncologist 15:1248-52. 2010
    ..At present in our institution some 20% of the cases are treated when nonpalpable. The aim of the present study is to analyze the characteristics and prognosis of such tumors treated in a single institution...
  28. doi request reprint Intraoperative radiotherapy during breast conserving surgery: a study on 1,822 cases treated with electrons
    Umberto Veronesi
    European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Breast Cancer Res Treat 124:141-51. 2010
    ..4 and 89.7%. ELIOT appears a promising feature in early breast cancer treated with breast conserving surgery, reducing the exposure of normal tissues to radiations and shortening the radiation course from 6 weeks to one single session...
  29. doi request reprint Sentinel lymph node biopsy in breast cancer: ten-year results of a randomized controlled study
    Umberto Veronesi
    European Institute of Oncology, Milan, Italy
    Ann Surg 251:595-600. 2010
    ..We present 10-year follow-up of our single-institute trial designed to compare outcomes in patients who received no axillary dissection if the sentinel node was negative, with patients who received complete axillary dissection...
  30. ncbi request reprint Sentinel node biopsy in breast cancer: early results in 953 patients with negative sentinel node biopsy and no axillary dissection
    Umberto Veronesi
    European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Eur J Cancer 41:231-7. 2005
    ..The 5 year overall survival rate of the whole series was 98%. Patients with negative sentinel node biopsies not submitted to axillary dissection show during follow-up a rate of overt axillary metastases that is lower than that expected...
  31. ncbi request reprint Intraoperative avidination for radionuclide therapy: a prospective new development to accelerate radiotherapy in breast cancer
    Giovanni Paganelli
    Division of Nuclear Medicine, European Institute of Oncology, Milan, Italy
    Clin Cancer Res 13:5646s-5651s. 2007
    ..In a continuous effort to seek for anticancer treatments with minimal side effects, we aim at proving the feasibility of the Intraoperative Avidination for Radionuclide Therapy, a new procedure for partial breast irradiation...
  32. doi request reprint Local therapy for breast cancer in malignant lymphoma survivors
    Mattia Intra
    Division of Breast Surgery, European Institute of Oncology, Milan, Italy
    Breast 20:S99-103. 2011
    ..We performed a retrospective review to assess the potential of performing breast conservative surgery and intraoperative radiotherapy with electrons (ELIOT), in these patients...
  33. ncbi request reprint Conservative treatment of breast cancer: its evolution
    Alberto Luini
    Division of Breast Surgery, European Institute of Oncology, Milan, Italy
    Breast Cancer Res Treat 94:195-8. 2005
    ..From an oncological perspective, outcome was found to be equally effective, and this key observation provided us with significant impetus to investigate the effects of reducing the radiotherapy field...
  34. ncbi request reprint Sentinel lymph node biopsy is feasible even after total mastectomy
    Mattia Intra
    Division of Breast Surgery, European Institute of Oncology, Milan, Italy
    J Surg Oncol 95:175-9. 2007
    ..Previous mastectomy is unanimously considered to represent an absolute technical contraindication to sentinel lymph node biopsy (SLNB)...
  35. doi request reprint Preliminary results of electron intraoperative therapy boost and hypofractionated external beam radiotherapy after breast-conserving surgery in premenopausal women
    Giovanni Battista Ivaldi
    Department of Radiation Oncology, European Institute of Oncology, Milan, Italy
    Int J Radiat Oncol Biol Phys 72:485-93. 2008
    ..To report the acute and preliminary data on late toxicity of a pilot study of boost with electron intraoperative therapy followed by hypofractionated external beam radiotherapy (HEBRT) of the whole breast...
  36. ncbi request reprint Italian randomized trial among women with hysterectomy: tamoxifen and hormone-dependent breast cancer in high-risk women
    Umberto Veronesi
    European Institute of Oncology, Milan, Italy
    J Natl Cancer Inst 95:160-5. 2003
    ..Such a strategy would greatly reduce the numbers of women who would need to take tamoxifen to obtain the same absolute reduction in breast cancer. These findings are exploratory and need to be confirmed in other randomized trials...
  37. doi request reprint Repeating conservative surgery after ipsilateral breast tumor reappearance: criteria for selecting the best candidates
    Oreste Gentilini
    Division of Breast Surgery, European Institute of Oncology, Milan, Italy
    Ann Surg Oncol 19:3771-6. 2012
    ..Mastectomy is still considered the treatment of first choice in patients with ipsilateral breast tumor recurrence (IBTR) after breast-conserving surgery (BCS) and whole-breast radiotherapy...
  38. doi request reprint Positive axillary sentinel lymph node: is axillary dissection always necessary?
    Viviana Galimberti
    Division ofSenology, European Institute of Oncology, Milan, Italy
    Breast 20:S96-8. 2011
    ..Ancillary analyses of the IBCSG 23-01 and AMAROS trials, still in follow-up, may be able to do this...
  39. doi request reprint Can we avoid axillary dissection in the micrometastatic sentinel node in breast cancer?
    Viviana Galimberti
    Division of Senology, Unit of Molecular Senology, European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy
    Breast Cancer Res Treat 131:819-25. 2012
    ..Nevertheless, a subset of patients might be at high risk of developing overt axillary disease and efforts should be made to identify such patients by ancillary analyses of the results of ongoing or recently published clinical trials...
  40. ncbi request reprint Nipple-sparing mastectomy in association with intra operative radiotherapy (ELIOT): A new type of mastectomy for breast cancer treatment
    Jean Yves Petit
    Division of Plastic Surgery, European Institute of Oncology, Milan, Italy
    Breast Cancer Res Treat 96:47-51. 2006
    ..In fact, although removal of the NAC greatly increases the patient's sensation of mutilation, and the risk of tumor involvement of the areola is reported as a very variable percentage, NAC excision still remains the standard treatment...
  41. ncbi request reprint Sentinel lymph node biopsy in male patients with early breast cancer
    Oreste Gentilini
    Division of Breast Surgery, European Institute of Oncology, 20141, Milan, Italy
    Oncologist 12:512-5. 2007
    ..After a median follow-up of 30 months (range, 1-63) no axillary reappearance of the disease occurred. As with women, we recommend SLNB in male patients with breast cancer and clinically negative axilla...
  42. ncbi request reprint Real-time in vivo dosimetry using micro-MOSFET detectors during intraoperative electron beam radiation therapy in early-stage breast cancer
    Mario Ciocca
    Department of Medical Physics, European Institute of Oncology, Milano, Italy
    Radiother Oncol 78:213-6. 2006
    ..In the present study, a further step was made, aiming at the improvement of the effectiveness of in vivo dosimetry, based on a real-time check of the dose...
  43. ncbi request reprint Clinicopathologic characteristics of 143 patients with synchronous bilateral invasive breast carcinomas treated in a single institution
    Mattia Intra
    Division of Breast Surgery, European Institute of Oncology, Milan, Italy
    Cancer 101:905-12. 2004
    ..Synchronous bilateral invasive breast carcinoma (SBIBC) ranged in incidence from 0.3% to as high as 12%...
  44. ncbi request reprint Can axillary and supraclavicular radiotherapy be avoided after breast-conserving surgery and axillary dissection in women with multiple involved axillary nodes? Experience at the European Institute of Oncology
    Viviana Galimberti
    Department of Senology, European Institute of Oncology, Milan, Italy
    Tumori 94:52-8. 2008
    ..We performed a retrospective analysis of patients with 4 or more axillary nodes involved and sufficient follow-up to provide indications as to whether our current treatment is adequate...
  45. doi request reprint Sentinel node biopsy is not a standard procedure in ductal carcinoma in situ of the breast: the experience of the European institute of oncology on 854 patients in 10 years
    Mattia Intra
    Division of Breast Surgery, European Institute of Oncology, Milan, Italy
    Ann Surg 247:315-9. 2008
    ....
  46. ncbi request reprint Second biopsy of axillary sentinel lymph node for reappearing breast cancer after previous sentinel lymph node biopsy
    Mattia Intra
    Division of Breast Surgery, European Institute of Oncology, Via Ripamonti, 435, 20141, Milan, Italy
    Ann Surg Oncol 12:895-9. 2005
    ..Although a previous SLNB is often considered a contraindication for a subsequent SLNB, few data support this concern...
  47. ncbi request reprint Unnecessary axillary node dissections in the sentinel lymph node era
    Mattia Intra
    Division of Breast Surgery, European Institute of Oncology, Via Ripamonti, 435, 20141 Milan, Italy
    Eur J Cancer 43:2664-8. 2007
    ..As the clinical indications to SNB are progressively extending to encompass most breast cancer patients with non-metastatic disease who were previously excluded, great effort should be made to avoid 'unnecessary ALNDs'...
  48. pmc A new option for early breast cancer patients previously irradiated for Hodgkin's disease: intraoperative radiotherapy with electrons (ELIOT)
    Mattia Intra
    Department of Breast Surgery, European Institute of Oncology, Milan, Italy
    Breast Cancer Res 7:R828-32. 2005
    ..Mastectomy is therefore recommended as the first option treatment in these women...
  49. doi request reprint Breast-conserving surgery in 201 very young patients (<35 years)
    Oreste Gentilini
    Division of Breast Surgery, European Institute of Oncology, Via Ripamonti 435, Milan, Italy
    Breast 19:55-8. 2010
    ..Surgical treatment of breast cancer in very young patients (<35 years) is still a matter of debate, since age is a predictive factor of local recurrence after breast conservation...
  50. ncbi request reprint When sentinel lymph node is intramammary
    Mattia Intra
    Breast Surgery Department, European Institute of Oncology, Via Ripamonti 435, Milan, MI 20141, Italy
    Ann Surg Oncol 15:1304-8. 2008
    ..Little attention has been placed to the presence of intramammary sentinel lymph nodes (intraMSLNs) on preoperative lymphoscintigraphy...
  51. doi request reprint Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23-01): a phase 3 randomised controlled trial
    Viviana Galimberti
    Molecular Senology Unit, Senology Division, European Institute of Oncology, Milan, Italy
    Lancet Oncol 14:297-305. 2013
    ..We designed IBCSG trial 23-01 to determine whether no axillary dissection was non-inferior to axillary dissection in patients with one or more micrometastatic (≤2 mm) sentinel nodes and tumour of maximum 5 cm...
  52. doi request reprint Influence of margin status on outcomes in lobular carcinoma: experience of the European Institute of Oncology
    Viviana Galimberti
    Division of Senology, European Institute of Oncology, University of Milan, Milan, Italy
    Ann Surg 253:580-4. 2011
    ..Our aim was to evaluate the influence of margin status on outcomes with a view assessing the appropriateness of conservative surgery in this breast cancer subtype...
  53. ncbi request reprint Predicting the status of axillary sentinel lymph nodes in 4351 patients with invasive breast carcinoma treated in a single institution
    Giuseppe Viale
    Department of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan, Milan, Italy
    Cancer 103:492-500. 2005
    ....
  54. ncbi request reprint Relationships between plasma insulin-like growth factor-I and insulin-like growth factor binding protein-3 and second breast cancer risk in a prevention trial of fenretinide
    Andrea Decensi
    Division of Chemoprevention, European Institute of Oncology, Milan 20141, Italy
    Clin Cancer Res 9:4722-9. 2003
    ..We determined whether IGF-I and IGFBP-3 predict second breast cancer risk, and whether their changes during fenretinide explain observed reductions in second breast cancer in women </=50 years of age...
  55. ncbi request reprint Surgical technique of intraoperative radiation therapy with electrons (ELIOT) in breast cancer: a lesson learned by over 1000 procedures
    Mattia Intra
    Division of Breast Surgery, European Institute of Oncology, University of Milan, Milan, Italy
    Surgery 140:467-71. 2006
  56. doi request reprint Long-term side effects and cosmetic outcome in a pool of breast cancer patients treated with intraoperative radiotherapy with electrons as sole treatment
    Maria Cristina Leonardi
    Division of Radiation Oncology, European Institute of Oncology, Milan, Italy
    Tumori 98:324-30. 2012
    ..To evaluate late toxicity and cosmetic outcome after intraoperative radiotherapy using electrons (ELIOT) as sole treatment modality in early breast cancer patients...
  57. doi request reprint Sentinel lymph node biopsy in pregnant patients with breast cancer
    Oreste Gentilini
    Division of Senology, European Institute of Oncology, Milan, Italy
    Eur J Nucl Med Mol Imaging 37:78-83. 2010
    ..Sentinel lymph node biopsy (SLNB) is currently not recommended in pregnant patients with breast cancer due to radiation concerns...
  58. doi request reprint Sentinel lymph node biopsy in multicentric breast cancer: five-year results in a large series from a single institution
    Oreste Gentilini
    Division of Senology, European Institute of Oncology, Milano, Italy
    Ann Surg Oncol 18:2879-84. 2011
    ..This study was designed to present the 5-year results of patients with multicentric breast cancer who underwent sentinel lymph node biopsy (SLNB) in a single institution...
  59. ncbi request reprint IART: intraoperative avidination for radionuclide treatment. A new way of partial breast irradiation
    Giovanni Paganelli
    Division of Nuclear Medicine, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Breast 16:17-26. 2007
    ..7 GBq 90Y-biotin (100mCi). A further large clinical trial facing IART in combination with reduced external-beam radiotherapy is, in our opinion, fully justified...
  60. doi request reprint Is electron beam intraoperative radiotherapy (ELIOT) safe in pregnant women with early breast cancer? In vivo dosimetry to assess fetal dose
    Viviana Galimberti
    Unit of Molecular Senology, Senology Department, European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy
    Ann Surg Oncol 16:100-5. 2009
    ..We conclude that studies on the use of ELIOT in pregnant women treated with conservative breast surgery are justified...
  61. ncbi request reprint The pilot trial on intraoperative radiotherapy with electrons (ELIOT): update on the results
    Alberto Luini
    Division of Breast Surgery, University of Milan, Milan, Italy
    Breast Cancer Res Treat 93:55-9. 2005
    ..At the European Institute of Oncology we started our study on ELIOT in 1999; the first step has been a phase I-II trial to test feasibility and tolerance of ELIOT in patients candidate to breast conserving surgery...
  62. ncbi request reprint Ipsilateral breast tumor reappearance in patients treated with conservative surgery after primary chemotherapy. The role of surgical margins on outcome
    Oreste Gentilini
    Division of Breast Surgery, European Institute of Oncology, Milan, Italy
    J Surg Oncol 94:375-9. 2006
    ..To evaluate the ipsilateral breast tumor reappearance (IBTR) rate after breast conservative surgery (BCS) following primary chemotherapy (PC) and to assess whether positive margins affects IBTR rate and overall survival (OS)...
  63. ncbi request reprint The evolution of the conservative approach to breast cancer
    Alberto Luini
    Division of Breast Surgery, European Institute of Oncology, Via Ripamonti 435, Milan, Italy
    Breast 16:120-9. 2007
    ..For this reason in our Institute we are now evaluating the feasibility of a reduction of the radiation field and the sensibility and sensitivity of new diagnostic approaches for axillary staging...
  64. ncbi request reprint Sentinel lymph node biopsy performed with local anesthesia in patients with early-stage breast carcinoma
    Alberto Luini
    Senology Division, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Arch Surg 137:1157-60. 2002
    ..This method represents an interesting development in breast-conserving surgery...
  65. ncbi request reprint Intraoperative radiation therapy for breast cancer: technical notes
    Umberto Veronesi
    Breast Department, European Institute of Oncology, Milan, Italy
    Breast J 9:106-12. 2003
    ..Here we report the two different techniques in use in these trials...
  66. ncbi request reprint Sentinel lymph node metastasis in microinvasive breast cancer
    Mattia Intra
    Department of Surgery, Breast Unit, University of Milan School of Medicine, Milan, Italy
    Ann Surg Oncol 10:1160-5. 2003
    ..Sentinel lymph node biopsy (SLNB) may obviate the need for CAD in these patients without compromising the staging of the axilla and the important prognostic information...
  67. ncbi request reprint Intraoperative radiotherapy during breast conserving surgery in patients previously treated with radiotherapy for Hodgkin's disease
    Mattia Intra
    Department of Breast Surgery, University of Milan, Italy
    Tumori 90:13-6. 2004
    ..Mastectomy is therefore recommended as the preferred treatment option in these women...
  68. ncbi request reprint Axillary radiotherapy instead of axillary dissection: a randomized trial. Italian Oncological Senology Group
    Stefano Zurrida
    Department of Senology, European Institute of Oncology, Milan, Italy
    Ann Surg Oncol 9:156-60. 2002
    ..We evaluated disease-free and overall survival in patients with early breast cancer treated by breast-conservation surgery without dissection of axillary lymph nodes, receiving or not receiving axillary radiotherapy (RT)...
  69. doi request reprint No more axillary dissection in patients with ductal intraepithelial neoplasia (DIN)
    Gabriel Farante
    Division of Senology, European Institute of Oncology, 20141 Milan, Italy
    Eur J Cancer 46:476-8. 2010
    ..Even if the SLNB is positive, AD should not be performed immediately but only in cases where an invasive component is found on definitive pathological examination of the DIN lesions...
  70. ncbi request reprint Sentinel node biopsy in elderly breast cancer patients
    Roberto Gennari
    Department of Surgery, European Institute of Oncology, Via Ripamonti Milano 435 20141, Italy
    Surg Oncol 13:193-6. 2004
    ..The aim of this study therefore was to assess the safety of the procedure as well as the rate of axillary recurrences after sentinel node biopsy in this older population...
  71. ncbi request reprint Stage migration after biopsy of internal mammary chain lymph nodes in breast cancer patients
    Viviana Galimberti
    Divisions of Senology, European Institute of Oncology, Milan, Italy
    Ann Surg Oncol 9:924-8. 2002
    ..Use of lymphoscintigraphy to visualize sentinel nodes reveals that IMNs often receive lymph from the area containing the tumor...
  72. ncbi request reprint Surgical technique of intraoperative radiotherapy in conservative treatment of limited-stage breast cancer
    Mattia Intra
    Breast Division, University of Milan, Italy
    Arch Surg 137:737-40. 2002
    ..In our experience, IORT for limited-stage breast carcinoma is easy to perform and only briefly prolongs the duration of the surgical procedure...
  73. ncbi request reprint Effect of tamoxifen on venous thromboembolic events in a breast cancer prevention trial
    Andrea Decensi
    Divisions of Chemoprevention, European Institute of Oncology, Milan, Italy
    Circulation 111:650-6. 2005
    ..Atherosclerosis may induce VTE, or the 2 conditions may share common risk factors. We assessed the effect of tamoxifen on VTE in a breast cancer prevention trial and studied its association with risk factors for VTE...
  74. ncbi request reprint Full-dose intraoperative radiotherapy with electrons in breast surgery: broadening the indications
    Mattia Intra
    Division of Breast Surgery, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Arch Surg 140:936-9. 2005
    ....
  75. ncbi request reprint [Intraoperative radiotherapy (IORT) in treatment of breast carcinoma--a new therapeutic alternative within the scope of breast-saving therapy? Current status and future prospects. Report of experiences from the European Institute of Oncology (EIO), Mailan
    W Gatzemeier
    Division of Senology, European Institute of Oncology, Milan, Italy
    Strahlenther Onkol 177:330-7. 2001
    ..In published series it has been demonstrated that the external boost can be replaced by intraoperative radiotherapy (IORT) where irradiation at a single dose from 10 up to 15 Gy was safely delivered directly to the tumor bed...
  76. pmc Immunodetection of bone marrow micrometastases in breast carcinoma patients and its correlation with primary tumour prognostic features
    S Menard
    Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Br J Cancer 69:1126-9. 1994
    ..Thus, the presence of immunoreactive cells in bone marrow correlates with the expression in the primary tumour of a marker of the metastatic potential of the tumour, the 67 kDa laminin receptor...
  77. pmc Prognosis based on primary breast carcinoma instead of pathological nodal status
    S Menard
    Department of Experimental Oncology E, Istituto Nazionale Tumori, Milan, Italy
    Br J Cancer 70:709-12. 1994
    ..Our data suggest that the primary tumour score provides more reliable prognostic information than pathological nodal status, and that axillary dissection can be avoided in a large number of patients...
  78. ncbi request reprint Sentinel lymph node biopsy and axillary dissection in breast cancer: results in a large series
    U Veronesi
    Senology Division, Istituto Europeo di Oncologia, Milan, Italy
    J Natl Cancer Inst 91:368-73. 1999
    ....
  79. ncbi request reprint Intraoperative radiotherapy: the debate continues
    Mattia Intra
    Division of Breast Surgery, European Institute of Oncology, Milan, Italy
    Lancet Oncol 5:340. 2004
  80. ncbi request reprint Prognostic factors for metachronous contralateral breast cancer: a comparison of the linear Cox regression model and its artificial neural network extension
    L Mariani
    Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Breast Cancer Res Treat 44:167-78. 1997
    ..Research for better prognostic variables should therefore continue...
  81. ncbi request reprint Effect of fenretinide on ovarian carcinoma occurrence
    Giuseppe De Palo
    Unit of Preventive Medicine and Cancer Family Clinic, Istituto Nazionale Tumori, Milan, Italy
    Gynecol Oncol 86:24-7. 2002
    ..The aim of this study was to update the effect of fenretinide, a synthetic vitamin A analogue proposed for chemoprevention, on the occurrence of ovarian carcinoma...
  82. ncbi request reprint Intraoperative electrons
    Roberto Orecchia
    Department of Radiation Oncology, European Institute of Oncology, University of Milan, Italy
    Semin Radiat Oncol 15:76-83. 2005
    ..In our opinion, ELIOT may be an excellent alternative to EBRT for the treatment of patients with early-stage breast cancer. However, intensive long-term follow-up is needed to fully evaluate local control and possible side effects...
  83. ncbi request reprint Synthetic retinoid fenretinide in breast cancer chemoprevention
    Bernardo Bonanni
    Division of Cancer Prevention and Genetics, European Institute of Oncology, Milano, Italy
    Expert Rev Anticancer Ther 7:423-32. 2007
    ..This review will highlight the role of fenretinide in breast cancer chemoprevention...
  84. ncbi request reprint A randomized trial of low-dose tamoxifen on breast cancer proliferation and blood estrogenic biomarkers
    Andrea Decensi
    Division of Chemoprevention, European Institute of Oncology, and University of Milan School of Medicine, Milan, Italy
    J Natl Cancer Inst 95:779-90. 2003
    ....
  85. ncbi request reprint Randomized trial of fenretinide (4-HPR) to prevent recurrences, new localizations and carcinomas in patients operated on for oral leukoplakia: long-term results
    Fausto Chiesa
    Head and Neck Division, European Institute of Oncology, Milan, Italy
    Int J Cancer 115:625-9. 2005
    ..The trial had to be stopped prematurely for very low recruitment and had insufficient power to reveal any protective effect against oral carcinoma; nevertheless, continuing studies on this promising chemopreventive are justified...
  86. ncbi request reprint Male breast cancer: a special therapeutic problem. Anything new? (Review)
    Roberto Gennari
    Department of Surgery, European Institute of Oncology, 20141 Milano, Italy
    Int J Oncol 24:663-70. 2004
    ....
  87. ncbi request reprint Axillary sentinel lymph node biopsy in patients with pure ductal carcinoma in situ of the breast
    Mattia Intra
    Department of Breast Surgery, European Institute of Oncology, Milan, Italy
    Arch Surg 138:309-13. 2003
    ....
  88. ncbi request reprint The nipple-sparing mastectomy: early results of a feasibility study of a new application of perioperative radiotherapy (ELIOT) in the treatment of breast cancer when mastectomy is indicated
    Jean Yves Petit
    Plastic Surgery Division, European Institute of Oncology, Milan, Italy
    Tumori 89:288-91. 2003
    ..The nipple-sparing mastectomy is performed leaving 5 mm of glandular tissue behind the nipple areola complex to preserve its blood supply. The reconstruction is immediately performed with a prosthesis or an autologous flap...
  89. doi request reprint High-intensity focused ultrasound ablation: effective and safe therapy for solid tumors in difficult locations
    Franco Orsi
    Interventional Radiology Unit, European Institute of Oncology, 435 Via Ripamonti, 20141 Milan, Italy
    AJR Am J Roentgenol 195:W245-52. 2010
    ..The aim of this study was to evaluate the safety and efficacy of ultrasound-guided high-intensity focused ultrasound therapeutic ablation of solid tumors in difficult locations...
  90. ncbi request reprint Innovation in care and research: meeting highlights from the seventh Milan Breast Cancer Conference (Milan, 15-17 June, 2005)
    Saverio Cinieri
    European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Breast 15:232-45. 2006
    ..This meeting report summarizes the highlights of the 12 sessions...
  91. ncbi request reprint Internal mammary node lymphoscintigraphy and biopsy in breast cancer
    G Paganelli
    Divisions of Nuclear Medicine, European Institute of Oncology, Milan, Italy
    Q J Nucl Med 46:138-44. 2002
    ..We investigated whether deep injection of tracer visualized internal mammary chain lymph (IMC) nodes more often, and assessed the impact of IMC status on disease staging...
  92. ncbi request reprint Histologic detection and clinical implications of micrometastases in axillary sentinel lymph nodes for patients with breast carcinoma
    G Viale
    Division of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
    Cancer 92:1378-84. 2001
    ....
  93. ncbi request reprint Tamoxifen for breast cancer among hysterectomised women
    U Veronesi
    Divisions of Senology, European Institute of Oncology, Milan, Italy
    Lancet 359:1122-4. 2002
    ..So far, no woman has died from breast cancer in this study. Decisions about introduction of tamoxifen to reduce risk of breast cancer remain important and open questions...
  94. doi request reprint Nipple sparing mastectomy with nipple areola intraoperative radiotherapy: one thousand and one cases of a five years experience at the European institute of oncology of Milan (EIO)
    J Y Petit
    Plastic Surgery Department, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Breast Cancer Res Treat 117:333-8. 2009
    ..Overall, 36 cases of metastases and 4 deaths were observed. No significant outcome difference was observed between the 800 patients receiving intraoperative radiotherapy (ELIOT) and the 201 patients receiving delayed irradiation...
  95. ncbi request reprint Extensive frozen section examination of axillary sentinel nodes to determine selective axillary dissection
    U Veronesi
    Senology Department, Istituto Europeo di Oncologia, Via G Ripamonti 435, 20141 Milano, Italy
    World J Surg 25:806-8. 2001
    ..Immunocytochemical staining for cytokeratins or other epithelial markers may be helpful for reducing the risk of missing micrometastatic foci...
  96. ncbi request reprint Chemoprevention trial of contralateral breast cancer with fenretinide. Rationale, design, methodology, organization, data management, statistics and accrual
    G De Palo
    Istituto Nazionale Tumori, University of Milan, Italy
    Tumori 83:884-94. 1997
    ..This paper describes the rationale, design, methodology, organization, data management, statistics and accrual of the participating population...
  97. ncbi request reprint Biologic activity of tamoxifen at low doses in healthy women
    A Decensi
    Chemoprevention Unit, European Institute of Oncology, Milan, Italy
    J Natl Cancer Inst 90:1461-7. 1998
    ..Since these adverse effects may be dose related, we investigated the effect of tamoxifen on several biomarkers when the drug was given at doses lower than those currently in use...
  98. pmc The effect of endocrine responsiveness on high-risk breast cancer treated with dose-intensive chemotherapy: results of International Breast Cancer Study Group Trial 15-95 after prolonged follow-up
    M Colleoni
    Department of Medicine, Research Unit in Medical Senology, European Institute of Oncology, Milan, Italy
    Ann Oncol 20:1344-51. 2009
    ..The role of adjuvant dose-intensive chemotherapy and its efficacy according to baseline features has not yet been established...
  99. doi request reprint Analysis of local and regional recurrences in breast cancer after conservative surgery
    E Botteri
    Division of Epidemiology and Biostatistics, European Institute of Oncology, Via Ripamonti 435, Milan, Italy
    Ann Oncol 21:723-8. 2010
    ..A minority of patients treated conservatively for breast cancer will develop local or regional recurrences. Our aim was to determine how their occurrence may be linked to the evolution of the disease...
  100. ncbi request reprint Primary chemotherapy in operable breast cancer with favorable prognostic factors: a pilot study evaluating the efficacy of a regimen with a low subjective toxic burden containing vinorelbine, 5-fluorouracil and folinic acid (FLN)
    F Nole
    Division of Medical Oncology, European Institute of Oncology, Milan, Italy
    Ann Oncol 10:993-6. 1999
    ....
  101. ncbi request reprint Chemoprevention of breast cancer: the Italian experience
    A Decensi
    Chemoprevention Unit, European Institute of Oncology, Milan, Italy
    J Cell Biochem Suppl 34:84-96. 2000
    ..Moreover, updated results of the secondary prevention trial of 4-H PR and of the primary prevention trial of tamoxifen are presented. Finally, the rationale for a reduction of tamoxifen dose in future prevention trials is provided...