Nadia Rosenthal

Summary

Affiliation: European Molecular Biology Laboratory
Country: Italy

Publications

  1. ncbi request reprint The future of regenerative therapy in patients with chronic heart failure
    Magdi Yacoub
    Harefield Heart Science Centre, National Heart and Lung Institute, Imperial College London, Harefield, Middlesex, UK
    Nat Clin Pract Cardiovasc Med 3:S133-5. 2006
  2. pmc Targeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regeneration
    Foteini Mourkioti
    European Molecular Biology Laboratory EMBL Mouse Biology Unit, Campus A Buzzati Traverso, Monterotondo Scalo, Italy
    J Clin Invest 116:2945-54. 2006
  3. ncbi request reprint Taking stock of our models: the function and future of stock centres
    Nadia Rosenthal
    Mouse Biology Programme, European Molecular Biology Laboratory, Via Ramarini 32, 00016 Monterotondo, Rome, Italy
    Nat Rev Genet 3:711-7. 2002
  4. pmc Youthful prospects for human stem-cell therapy. In another few decades, revised attitudes toward stem cells could lead to disease prevention and life extension
    Nadia Rosenthal
    Mouse Biology Unit, EMBL Monterotondo Outstation, Italy
    EMBO Rep 6:S30-4. 2005
  5. ncbi request reprint Growth factor enhancement of cardiac regeneration
    Nadia Rosenthal
    Mouse Biology Unit, EMBL Monterotondo Outstation, Monterotondo Rome 00016, Italy
    Cell Transplant 15:S41-5. 2006
  6. ncbi request reprint Gene therapy for cardiac cachexia?
    Nadia Rosenthal
    Mouse Biology Programme, European Molecular Biology Laboratory EMBL, Monterotondo, Rome, Italy
    Int J Cardiol 85:185-91. 2002
  7. ncbi request reprint Prometheus's vulture and the stem-cell promise
    Nadia Rosenthal
    Mouse Biology Programme, European Molecular Biology Laboratory Mouse Biology Programme, Rome, Italy
    N Engl J Med 349:267-74. 2003
  8. doi request reprint Distinct roles for cell-autonomous Notch signaling in cardiomyocytes of the embryonic and adult heart
    Paschalis Kratsios
    Mouse Biology Unit, European Molecular Biology Laboratory, Campus A Buzzati Traverso, Rome, Italy
    Circ Res 106:559-72. 2010
  9. pmc A naturally occurring calcineurin variant inhibits FoxO activity and enhances skeletal muscle regeneration
    Enrique Lara-Pezzi
    European Molecular Biology Laboratory EMBL, Mouse Biology Unit, Campus Buzzatti Traverso, Monterotondo Scalo, 00016 Rome, Italy
    J Cell Biol 179:1205-18. 2007
  10. pmc Revealing new mouse epicardial cell markers through transcriptomics
    Lars Bochmann
    Mouse Biology Unit, European Molecular Biology Laboratory, Monterotondo, Italy
    PLoS ONE 5:e11429. 2010

Collaborators

Detail Information

Publications46

  1. ncbi request reprint The future of regenerative therapy in patients with chronic heart failure
    Magdi Yacoub
    Harefield Heart Science Centre, National Heart and Lung Institute, Imperial College London, Harefield, Middlesex, UK
    Nat Clin Pract Cardiovasc Med 3:S133-5. 2006
    ....
  2. pmc Targeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regeneration
    Foteini Mourkioti
    European Molecular Biology Laboratory EMBL Mouse Biology Unit, Campus A Buzzati Traverso, Monterotondo Scalo, Italy
    J Clin Invest 116:2945-54. 2006
    ..Our results establish IKK2/NF-kappaB signaling as an important modulator of muscle homeostasis and suggest a combined role for IKK inhibitors and growth factors in the therapy of muscle diseases...
  3. ncbi request reprint Taking stock of our models: the function and future of stock centres
    Nadia Rosenthal
    Mouse Biology Programme, European Molecular Biology Laboratory, Via Ramarini 32, 00016 Monterotondo, Rome, Italy
    Nat Rev Genet 3:711-7. 2002
    ..But they need forward planning, international cooperation and secure funding to keep pace with the explosion in functional genomics that relies so heavily on them...
  4. pmc Youthful prospects for human stem-cell therapy. In another few decades, revised attitudes toward stem cells could lead to disease prevention and life extension
    Nadia Rosenthal
    Mouse Biology Unit, EMBL Monterotondo Outstation, Italy
    EMBO Rep 6:S30-4. 2005
  5. ncbi request reprint Growth factor enhancement of cardiac regeneration
    Nadia Rosenthal
    Mouse Biology Unit, EMBL Monterotondo Outstation, Monterotondo Rome 00016, Italy
    Cell Transplant 15:S41-5. 2006
    ....
  6. ncbi request reprint Gene therapy for cardiac cachexia?
    Nadia Rosenthal
    Mouse Biology Programme, European Molecular Biology Laboratory EMBL, Monterotondo, Rome, Italy
    Int J Cardiol 85:185-91. 2002
    ..The potential therapeutic role of locally expressed IGF-1 is discussed in the context of current strategies for the attenuation of cardiac cachexia...
  7. ncbi request reprint Prometheus's vulture and the stem-cell promise
    Nadia Rosenthal
    Mouse Biology Programme, European Molecular Biology Laboratory Mouse Biology Programme, Rome, Italy
    N Engl J Med 349:267-74. 2003
  8. doi request reprint Distinct roles for cell-autonomous Notch signaling in cardiomyocytes of the embryonic and adult heart
    Paschalis Kratsios
    Mouse Biology Unit, European Molecular Biology Laboratory, Campus A Buzzati Traverso, Rome, Italy
    Circ Res 106:559-72. 2010
    ....
  9. pmc A naturally occurring calcineurin variant inhibits FoxO activity and enhances skeletal muscle regeneration
    Enrique Lara-Pezzi
    European Molecular Biology Laboratory EMBL, Mouse Biology Unit, Campus Buzzatti Traverso, Monterotondo Scalo, 00016 Rome, Italy
    J Cell Biol 179:1205-18. 2007
    ..This unique mode of action distinguishes the CnAbeta1 isoform as a candidate for interventional strategies in muscle wasting treatment...
  10. pmc Revealing new mouse epicardial cell markers through transcriptomics
    Lars Bochmann
    Mouse Biology Unit, European Molecular Biology Laboratory, Monterotondo, Italy
    PLoS ONE 5:e11429. 2010
    ..Although some genes involved in epicardial function have been identified, a detailed molecular profile of epicardial gene expression has not been available...
  11. ncbi request reprint Signalling pathways in cardiac regeneration
    Maria Paola Santini
    Mouse Biology Unit, EMBL Monterotondo Outstation, Via Ramarini 32, 00016 Monterotondo, Rome, Italy
    Novartis Found Symp 274:228-38; discussion 239-43, 272-6. 2006
    ..In both models, novel signalling pathways are employed, suggesting specific mechanisms through which mIGF1 improves regeneration and providing potential targets for clinical intervention...
  12. pmc A CREB-C/EBPbeta cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair
    Daniela Ruffell
    Mouse Biology Unit, European Molecular Biology Laboratory, Via Ramarini 32, 00015 Monterotondo, Italy
    Proc Natl Acad Sci U S A 106:17475-80. 2009
    ..CREB-mediated induction of Cebpb expression is therefore required in infiltrating macrophages for upregulation of M2-specific genes and muscle regeneration, providing a direct genetic link between these two processes...
  13. pmc E-peptides control bioavailability of IGF-1
    Marianne Smedegaard Hede
    European Molecular Biology Laboratory EMBL Mouse Biology Unit, Monterotondo, Rome, Italy
    PLoS ONE 7:e51152. 2012
    ..Thus, the E-peptides control IGF-1 bioavailability by preventing systemic circulation, offering a potentially powerful way to tether IGF-1 and other therapeutic proteins to the site of synthesis and/or administration...
  14. pmc Enhancing repair of the mammalian heart
    Maria Paola Santini
    European Molecular Biology Laboratory, Mouse Biology Unit Monterotondo, Rome, Italy
    Circ Res 100:1732-40. 2007
    ..The robust response achieved with the mIGF-1 isoform provides a mechanistic basis for clinically feasible therapeutic strategies for improving the outcome of heart disease...
  15. ncbi request reprint IGF-1, inflammation and stem cells: interactions during muscle regeneration
    Foteini Mourkioti
    EMBL Mouse Biology Unit Campus A Buzzati Traverso, Via Ramarini 32, 00016 Monterotondo Scalo RM, Italy
    Trends Immunol 26:535-42. 2005
    ..Recent studies on the role of IGF-1 in the promotion of cell recruitment to the injured muscle and the subsequent resolution of the inflammatory response have unveiled new perspectives into local repair mechanisms...
  16. ncbi request reprint The mouse ascending: perspectives for human-disease models
    Nadia Rosenthal
    Mouse Biology Unit, EMBL Monterotondo Outstation, Via Ramarini 32, 00016, Monterotondo, Rome, Italy
    Nat Cell Biol 9:993-9. 2007
    ....
  17. pmc NF-kappaB signaling in skeletal muscle: prospects for intervention in muscle diseases
    Foteini Mourkioti
    EMBL Mouse Biology Unit, Campus A Buzzati Traverso, 00015, Monterotondo Scalo, Italy
    J Mol Med (Berl) 86:747-59. 2008
    ..Understanding the exact role of NF-kappaB in muscle cells will allow better therapeutic manipulations in the setting of human muscle diseases...
  18. ncbi request reprint Regulation of muscle atrophy in aging and disease
    Manlio Vinciguerra
    Mouse Biology Unit, European Molecular Biology Laboratory, Via Ramarini, 32, 00015 Monterotondo Rome, Italy
    Adv Exp Med Biol 694:211-33. 2010
    ....
  19. pmc ROCK2 and its alternatively spliced isoform ROCK2m positively control the maturation of the myogenic program
    Michele Pelosi
    EMBL Mouse Biology Unit, Campus Buzzati Traverso, Via Ramarini 32, 00016 Monterotondo Scalo, Roma, Italy
    Mol Cell Biol 27:6163-76. 2007
    ....
  20. ncbi request reprint Human hepatocytes in mice receiving pre-immune injection with human cord blood cells
    Paolo Turrini
    Pharmacology Department, Istituto di Ricerca di Biologia Molecolare P Angeletti, Merck Sharp and Dohme Research Laboratories, Rome, Italy
    Biochem Biophys Res Commun 326:66-73. 2005
    ..The current report, besides providing new evidence of the potential of hCBCD34(+) cells to generate human hepatocyte-like cells, suggests novel strategies for generating immunocompetent mice harboring humanized liver...
  21. pmc Multiple congenital malformations of Wolf-Hirschhorn syndrome are recapitulated in Fgfrl1 null mice
    Catarina Catela
    European Molecular Biology Laboratory, Mouse Biology Unit, Monterotondo, Italy
    Dis Model Mech 2:283-94. 2009
    ..Together, these data support a wider role for Fgfrl1 in development, implicate FGFRL1 insufficiency in WHS, and provide a novel animal model to dissect the complex aetiology of this human disease...
  22. pmc Different modes of hypertrophy in skeletal muscle fibers
    Angelika C Paul
    Mouse Biology Program, European Molecular Biology Laboratory, 00016 Monterotondo Scalo, Rome, Italy
    J Cell Biol 156:751-60. 2002
    ..Different modes of muscle hypertrophy in domestic and laboratory animals have important implications for building appropriate models of human neuromuscular disease...
  23. pmc SirT1 in muscle physiology and disease: lessons from mouse models
    Manlio Vinciguerra
    Mouse Biology Unit, European Molecular Biology Laboratory, Campus A Buzzati Traverso, Monterotondo Scalo, Rome, Italy
    Dis Model Mech 3:298-303. 2010
    ....
  24. pmc Identification of novel peptide hormones in the human proteome by hidden Markov model screening
    Olivier Mirabeau
    Mouse Biology Unit, EMBL, 00016 Monterotondo, Italy
    Genome Res 17:320-7. 2007
    ..Peptide hormones and their receptors are important diagnostic and therapeutic targets, and our results suggest that spexin and augurin are novel peptide hormones likely to be involved in physiological homeostasis...
  25. pmc Machinations of the marrow
    Nadia Rosenthal
    European Molecular Biology Laboratory, Mouse Biology Programme, Monterotondo, Rome, Italy
    J Clin Invest 111:29-30. 2003
  26. ncbi request reprint Phenostat: visualization and statistical tool for analysis of phenotyping data
    Eli Reuveni
    Mouse Biology Unit, European Molecular Biology Laboratory EMBL, 00016, Monterotondo, Italy
    Mamm Genome 18:677-81. 2007
    ..Phenostat is freely available to academic institutions and nonprofit organizations and can be used from our website at: (http://www.bioinfo.embl.it/phenostat/)...
  27. pmc Overexpression of mIGF-1 in keratinocytes improves wound healing and accelerates hair follicle formation and cycling in mice
    Ekaterina Semenova
    European Molecular Biology Laboratory EMBL Mouse Biology Unit, Campus A Buzzati Traverso, Monterotondo Scalo, Roma, Italy
    Am J Pathol 173:1295-310. 2008
    ..Our analysis supports the use of mIGF-1 for skin and hair regeneration and describes a potential cell type-restricted action...
  28. pmc Vasopressin-dependent myogenic cell differentiation is mediated by both Ca2+/calmodulin-dependent kinase and calcineurin pathways
    Bianca Maria Scicchitano
    Department of Histology and Medical Embryology, University of Rome La Sapienza, 00161 Roma, Italy
    Mol Biol Cell 16:3632-41. 2005
    ..Although MEF2-NFATc1 complexes appear to regulate the expression of an early muscle-specific gene product (myogenin), the activation of late muscle-specific gene expression (MCK) involves the formation of complexes including GATA2...
  29. ncbi request reprint The stem cell challenge
    Robert Lanza
    Institute of Regenerative Medicine, Wake Forest University School of Medicine, USA
    Sci Am 290:92-9. 2004
  30. ncbi request reprint The role of stem cells in skeletal and cardiac muscle repair
    Miranda D Grounds
    Department of Anatomy and Human Biology, The University of Western Australia, Crawley, Western Australia
    J Histochem Cytochem 50:589-610. 2002
    ..For heart muscle, experiments showing the participation of bone marrow-derived stem cells and endothelial cells in the repair of damaged cardiac muscle are encouraging...
  31. ncbi request reprint Targeted expression of insulin-like growth factor-I reduces early myofiber necrosis in dystrophic mdx mice
    Thea Shavlakadze
    School of Anatomy and Human Biology, University of Western Australia, Crawley, Perth, Western Australia 6009, Australia
    Mol Ther 10:829-43. 2004
    ..This mechanism of action can account for the long-term reduced severity of the dystropathology in mdx mice that overexpress mIGF-1 and provides promising opportunities for therapeutic strategies...
  32. pmc Muscle-specific expression of IGF-1 blocks angiotensin II-induced skeletal muscle wasting
    Yao Hua Song
    Tulane University Health Sciences Center, New Orleans, Louisiana 70112 2699, USA
    J Clin Invest 115:451-8. 2005
    ..Because the renin-angiotensin system is activated in many catabolic conditions, our findings have broad implications for understanding mechanisms of skeletal muscle wasting and provide a rationale for new therapeutic approaches...
  33. pmc Muscle expression of a local Igf-1 isoform protects motor neurons in an ALS mouse model
    Gabriella Dobrowolny
    Department of Histology and Medical Embryology, CE BEMM and Interuniversity Institute of Myology, University of Rome La Sapienza, 14 00161 Rome, Italy
    J Cell Biol 168:193-9. 2005
    ..These studies establish skeletal muscle as a primary target for the dominant action of inherited SOD1 mutation and suggest that muscle fibers provide appropriate factors, such as mIgf-1, for neuron survival...
  34. pmc Muscle-specific expression of insulin-like growth factor I counters muscle decline in mdx mice
    Elisabeth R Barton
    Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Biol 157:137-48. 2002
    ..These results suggest that a combination of promoting muscle regenerative capacity and preventing muscle necrosis could be an effective treatment for the secondary symptoms caused by the primary loss of dystrophin...
  35. ncbi request reprint Local expression of IGF-1 accelerates muscle regeneration by rapidly modulating inflammatory cytokines and chemokines
    Laura Pelosi
    Department of Histology and Medical Embryology, University of Rome La Sapienza, Via A Scarpa, 14 Rome 00161, Italy
    FASEB J 21:1393-402. 2007
    ..By modulating the inflammatory response and reducing fibrosis, supplemental mIGF-1 creates a qualitatively different environment for sustaining more efficient muscle regeneration and repair...
  36. ncbi request reprint Reconciling data from transgenic mice that overexpress IGF-I specifically in skeletal muscle
    Thea Shavlakadze
    School of Anatomy and Human Biology, The University of Western Australia, Crawley, Perth, Western Australia 6009, Australia
    Growth Horm IGF Res 15:4-18. 2005
    ..Full understanding of these complex in vivo issues is essential, not only for skeletal muscle but for many other tissues, in order to effectively extend observations derived from transgenic studies into potential clinical situations...
  37. pmc Insulin-like growth factor I-mediated skeletal muscle hypertrophy is characterized by increased mTOR-p70S6K signaling without increased Akt phosphorylation
    Yao Hua Song
    Department of Medicine, Section of Cardiology, Tulane University School of Medicine, New Orleans, LA 70112 2699, USA
    J Investig Med 53:135-42. 2005
    ..Insulin-like growth factor I (IGF-I) is an anabolic hormone that is known to induce skeletal muscle hypertrophy. However, the signaling pathways mediating IGF-I's hypertrophic effect in vivo are unknown...
  38. ncbi request reprint Transgenic overexpression of locally acting insulin-like growth factor-1 inhibits ubiquitin-mediated muscle atrophy in chronic left-ventricular dysfunction
    P Christian Schulze
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Circ Res 97:418-26. 2005
    ....
  39. pmc Stem cell-mediated muscle regeneration is enhanced by local isoform of insulin-like growth factor 1
    Antonio Musaro
    Department of Histology and Medical Embryology and Centro Eccellenza Biologia e Medicina Molecolare, University of Rome La Sapienza, 00161 Rome, Italy
    Proc Natl Acad Sci U S A 101:1206-10. 2004
    ..These data implicate mIGF-1 as a powerful enhancer of the regeneration response, mediating the recruitment of bone marrow cells to sites of tissue damage and augmenting local repair mechanisms...
  40. ncbi request reprint A caudorostral wave of RALDH2 conveys anteroposterior information to the cardiac field
    Tatiana Hochgreb
    Laboratório de Genética e Cardiologia Molecular InCor HC FMUSP 05403 900 São Paulo SP, Brazil
    Development 130:5363-74. 2003
    ..Identification of the caudorostral wave of RALDH2 as the endogenous source of RA establishing cardiac AP fates provides a useful model to approach the mechanisms whereby the vertebrate embryo confers axial information on its organs...
  41. doi request reprint Analysis of CRE-mediated recombination driven by myosin light chain 1/3 regulatory elements in embryonic and adult skeletal muscle: a tool to study fiber specification
    Foteini Mourkioti
    Genesis 46:424-30. 2008
    ..The MLC-Cre transgenic mouse can be used in conjunction with conditional alleles to study both developmental patterning and maintenance of fast fiber-type phenotypes...
  42. doi request reprint Interleukin-10 from transplanted bone marrow mononuclear cells contributes to cardiac protection after myocardial infarction
    Jana S Burchfield
    Department of Molecular Cardiology, Internal Medicine III, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Circ Res 103:203-11. 2008
    ..These results suggest that BM-MNCs mediate cardiac protection after myocardial infarction and this is, at least in part, dependent on IL-10...
  43. pmc The European dimension for the mouse genome mutagenesis program
    Johan Auwerx
    Mouse Clinical Institute MCI, Illkirch, Strasbourg, France corrected
    Nat Genet 36:925-7. 2004
    ..The combined efforts will accelerate our understanding of gene function and of human health and disease...
  44. ncbi request reprint Derive and conquer: sourcing and differentiating stem cells for therapeutic applications
    Irina Klimanskaya
    Advanced Cell Technology, 381 Plantation Street, Worcester, Massachusetts 01605, USA
    Nat Rev Drug Discov 7:131-42. 2008
    ..Here, we address some of the problems associated with the sourcing of human ESCs and discuss the current status of stem-cell differentiation technology...
  45. ncbi request reprint The neuroprotective effects of a locally acting IGF-1 isoform
    Antonio Musaro
    Department of Histology and Medical Embryology, CE BEMM and Interuniversity Institute of Myology, University of Rome La Sapienza, Italy
    Exp Gerontol 42:76-80. 2007
    ..In this review, we will discuss the role of IGF-1 isoforms in neuromuscular diseases and the contribution of muscle-produced IGF-1 (mIGF-1) to motor neuron survival and activity...
  46. ncbi request reprint Targeted deletion of the MLC1f/3f downstream enhancer results in precocious MLC expression and mesoderm ablation
    Ping Jiang
    Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Dev Biol 243:281-93. 2002
    ....