Maria Rescigno

Summary

Affiliation: European Institute of Oncology
Country: Italy

Publications

  1. doi The intestinal epithelial barrier in the control of homeostasis and immunity
    Maria Rescigno
    European Institute of Oncology, Department of Experimental Oncology, Milan, Italy
    Trends Immunol 32:256-64. 2011
  2. doi Interactions among dendritic cells, macrophages, and epithelial cells in the gut: implications for immune tolerance
    Maria Rescigno
    Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
    Curr Opin Immunol 20:669-75. 2008
  3. pmc The yin and yang of intestinal epithelial cells in controlling dendritic cell function
    Iliyan D Iliev
    Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy
    J Exp Med 204:2253-7. 2007
  4. pmc Comparison of the immunomodulatory properties of three probiotic strains of Lactobacilli using complex culture systems: prediction for in vivo efficacy
    Erika Mileti
    Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
    PLoS ONE 4:e7056. 2009
  5. pmc Contrasting roles of SPARC-related granuloma in bacterial containment and in the induction of anti-Salmonella typhimurium immunity
    Gianluca Rotta
    Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy
    J Exp Med 205:657-67. 2008
  6. ncbi Challenges and prospects of immunotherapy as cancer treatment
    Maria Rescigno
    Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti, 435, 20141, Milan, Italy
    Biochim Biophys Acta 1776:108-23. 2007
  7. doi Dendritic cells in tolerance induction for the treatment of autoimmune diseases
    Maria Rescigno
    Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
    Eur J Immunol 40:2119-23. 2010
  8. doi Before they were gut dendritic cells
    Maria Rescigno
    Department of Experimental Oncology, European Institute of Oncology, I 20141 Milan, Italy
    Immunity 31:454-6. 2009
  9. doi Functional specialization of antigen presenting cells in the gastrointestinal tract
    Maria Rescigno
    European Institute of Oncology, Department of Experimental Oncology, Via Adamello 16, 20139 Milan, Italy
    Curr Opin Immunol 22:131-6. 2010
  10. ncbi The role of altered microbial signaling via mutant NODs in intestinal inflammation
    Maria Rescigno
    Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
    Curr Opin Gastroenterol 23:21-6. 2007

Detail Information

Publications62

  1. doi The intestinal epithelial barrier in the control of homeostasis and immunity
    Maria Rescigno
    European Institute of Oncology, Department of Experimental Oncology, Milan, Italy
    Trends Immunol 32:256-64. 2011
    ..If dysregulated, this immunomodulatory function of epithelial cells might contribute to the development of intestinal inflammation...
  2. doi Interactions among dendritic cells, macrophages, and epithelial cells in the gut: implications for immune tolerance
    Maria Rescigno
    Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
    Curr Opin Immunol 20:669-75. 2008
    ..Understanding how tolerance is achieved at mucosal sites may thus be exploited to re-establish tissue homeostasis...
  3. pmc The yin and yang of intestinal epithelial cells in controlling dendritic cell function
    Iliyan D Iliev
    Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy
    J Exp Med 204:2253-7. 2007
    ..Differential epithelial cell (EC) responses to commensals and pathogens may control these two tolorogenic and immunogenic functions of DCs...
  4. pmc Comparison of the immunomodulatory properties of three probiotic strains of Lactobacilli using complex culture systems: prediction for in vivo efficacy
    Erika Mileti
    Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
    PLoS ONE 4:e7056. 2009
    ..In this report we analyzed the immunological activity of three strains of Lactobacillus to predict their in vivo efficacy in protecting against experimental colitis...
  5. pmc Contrasting roles of SPARC-related granuloma in bacterial containment and in the induction of anti-Salmonella typhimurium immunity
    Gianluca Rotta
    Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy
    J Exp Med 205:657-67. 2008
    ..typhimurium immunity. This highlights a new function of matricellular proteins in bacterial infection and suggests that initial containment of bacteria can have drawbacks...
  6. ncbi Challenges and prospects of immunotherapy as cancer treatment
    Maria Rescigno
    Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti, 435, 20141, Milan, Italy
    Biochim Biophys Acta 1776:108-23. 2007
    ....
  7. doi Dendritic cells in tolerance induction for the treatment of autoimmune diseases
    Maria Rescigno
    Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
    Eur J Immunol 40:2119-23. 2010
    ..This Viewpoint analyzes the potential use of DC for induction of antigen-specific tolerance in autoimmune disease settings...
  8. doi Before they were gut dendritic cells
    Maria Rescigno
    Department of Experimental Oncology, European Institute of Oncology, I 20141 Milan, Italy
    Immunity 31:454-6. 2009
    ..Gut lamina propria dendritic cell (DC) subsets have specialized functions. In this issue of Immunity, Varol et al. (2009) and Bogunovic et al. (2009) describe the different blood precursors for CD103(+) and CD103(-) DC subsets...
  9. doi Functional specialization of antigen presenting cells in the gastrointestinal tract
    Maria Rescigno
    European Institute of Oncology, Department of Experimental Oncology, Via Adamello 16, 20139 Milan, Italy
    Curr Opin Immunol 22:131-6. 2010
    ..The interaction between these cell types is required for the dynamic regulation of the immune response...
  10. ncbi The role of altered microbial signaling via mutant NODs in intestinal inflammation
    Maria Rescigno
    Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
    Curr Opin Gastroenterol 23:21-6. 2007
    ..These proteins are involved in recognizing bacterial components or their degradation constituents that are delivered within the cytoplasm. In this review we will analyze the role of NOD proteins in regulating immune homeostasis...
  11. ncbi Dendritic cells in oral tolerance in the gut
    Maria Rescigno
    Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
    Cell Microbiol 13:1312-8. 2011
    ..Hence specialized functions are associated to different subsets of antigen presenting cells and different organs...
  12. doi Dendritic cells in bacteria handling in the gut
    Maria Rescigno
    Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
    J Leukoc Biol 90:669-72. 2011
    ..Here, we summarize the characteristics of two major subtypes of phagocytes in the gut (CX3CR1(+) and CD103(+)) and pDCs and analyze their possible involvement in bacterial handling...
  13. pmc Dendritic cells in intestinal homeostasis and disease
    Maria Rescigno
    Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
    J Clin Invest 119:2441-50. 2009
    ....
  14. ncbi The pathogenic role of intestinal flora in IBD and colon cancer
    Maria Rescigno
    Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
    Curr Drug Targets 9:395-403. 2008
    ..In this review we will analyze how the microflora interacts with the host and how deregulation of this interaction can lead to inflammatory disorders and eventually also to cancer...
  15. doi Lamina propria dendritic cells: for whom the bell TOLLs?
    Maria Rescigno
    Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
    Eur J Immunol 38:1483-6. 2008
    ..DC either do not express TLR or they express them but respond in a non-inflammatory mode. In this commentary, these findings are discussed in the context of available knowledge on lamina propria DC...
  16. doi Gut CD103+ dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction
    Gianluca Matteoli
    Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, Milan, Italy
    Gut 59:595-604. 2010
    ..IDO-expressing DCs sustain and differentiate Tregs. The aim of this study was to investigate the expression and the possible physiological role of IDO in the tolerogenic properties of intestinal DCs...
  17. ncbi Accelerated dendritic-cell migration and T-cell priming in SPARC-deficient mice
    Sabina Sangaletti
    Immunotherapy and Gene Therapy Unit, Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, 20133 Milano, Italy
    J Cell Sci 118:3685-94. 2005
    ....
  18. ncbi Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells
    Monica Rimoldi
    Department of Experimental Oncology, European Institute of Oncology, I 20141 Milan, Italy
    Nat Immunol 6:507-14. 2005
    ..This control of immune responses seemed to be lost in patients with Crohn disease. Thus, the intimate interplay between intestinal epithelial cells and dendritic cells may help to maintain gut immune homeostasis...
  19. ncbi Oral tolerance can be established via gap junction transfer of fed antigens from CX3CR1⁺ macrophages to CD103⁺ dendritic cells
    Elisa Mazzini
    Department of Experimental Oncology, European Institute of Oncology, I 20139 Milan, Italy
    Immunity 40:248-61. 2014
    ..This functional cooperation between intestinal phagocytes might be a mechanism to avoid the exposure of tolerogenic DCs to the intestinal microbiota...
  20. ncbi Monocyte-derived dendritic cells activated by bacteria or by bacteria-stimulated epithelial cells are functionally different
    Monica Rimoldi
    Department of Experimental Oncology, European Institute of Oncology, Istituto di Ricerche Farmacologiche, Mario Negri, Milan, Italy
    Blood 106:2818-26. 2005
    ..These results suggest that ECs are not simply a barrier to bacteria entering via the oral route, but they actively influence the activating properties of DCs...
  21. doi Bacteria-induced gap junctions in tumors favor antigen cross-presentation and antitumor immunity
    Fabiana Saccheri
    Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, Milan 20141, Italy
    Sci Transl Med 2:44ra57. 2010
    ..In conclusion, we exploited an antimicrobial response present in tumor cells to activate cytotoxic CD8 T cells specific for tumor-generated peptides that could directly recognize and kill tumor cells...
  22. pmc The adhesion molecule L1 regulates transendothelial migration and trafficking of dendritic cells
    Luigi Maddaluno
    The FIRC Institute of Molecular Oncology, 20139 Milan, Italy
    J Exp Med 206:623-35. 2009
    ..These observations might offer novel therapeutic perspectives for the treatment of certain immunological disorders...
  23. doi Probiotic and postbiotic activity in health and disease: comparison on a novel polarised ex-vivo organ culture model
    Katerina Tsilingiri
    Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
    Gut 61:1007-15. 2012
    ..This may be due to the lack of reliable preclinical models for testing the efficacy of different strains...
  24. pmc Lipopolysaccharide or whole bacteria block the conversion of inflammatory monocytes into dendritic cells in vivo
    Gianluca Rotta
    Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti, 435, 20141 Milano, Italy
    J Exp Med 198:1253-63. 2003
    ....
  25. doi Bacterial sensor triggering receptor expressed on myeloid cells-2 regulates the mucosal inflammatory response
    Carmen Correale
    Division of Gastroenterology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy
    Gastroenterology 144:346-356.e3. 2013
    ..We investigated the expression of TREM-2 in the intestinal lamina propria and its role in the development of colonic inflammation...
  26. doi Intestinal epithelial cells control dendritic cell function
    Maria Rescigno
    European Institute of Oncology, Milan, Italy
    J Pediatr Gastroenterol Nutr 46:E17-9. 2008
  27. doi Intra-tumoral Salmonella typhimurium induces a systemic anti-tumor immune response that is directed by low-dose radiation to treat distal disease
    Francesca Avogadri
    Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, Milan, Italy
    Eur J Immunol 38:1937-47. 2008
    ..We demonstrate that Salmonella-based therapy coupled to low-dose radiotherapy dampens tumor immune escape mechanisms at different levels and allows controlling systemic disease in a CD8+ T cell-dependent manner...
  28. ncbi Cancer immunotherapy based on killing of Salmonella-infected tumor cells
    Francesca Avogadri
    Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
    Cancer Res 65:3920-7. 2005
    ..This is effective in retarding the growth of untreated established distant tumors and in protecting the mice from subsequent tumor challenges...
  29. ncbi CCR6(+) dendritic cells: the gut tactical-response unit
    Maria Rescigno
    Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti, 435, 20141 Milano, Italy
    Immunity 24:508-10. 2006
    ..In this issue of Immunity, it has been found that a distinct subset of CCR6-expressing dendritic cells are absolutely required to activate anti-Salmonella-specific T cells...
  30. doi Monocyte-derived dendritic cells from Crohn patients show differential NOD2/CARD15-dependent immune responses to bacteria
    Valentina Salucci
    Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
    Inflamm Bowel Dis 14:812-8. 2008
    ..NOD2 is an intracellular receptor of muramyl dipeptide (MDP), a component of peptidoglycan present in the cell wall of gram-positive (G+) and gram-negative (G-) bacteria...
  31. ncbi Intestinal epithelial cells control dendritic cell function
    Monica Rimoldi
    European Institute of Oncology, Department of Experimental Oncology, Via Ripamonti 435, 20141 Milano, Italy
    Ann N Y Acad Sci 1029:66-74. 2004
    ..In conclusion, epithelial cells are not simply a barrier to bacteria entering via the oral route, but actively influence the activating properties of bystander DC...
  32. ncbi Should probiotics be tested on ex vivo organ culture models?
    Katerina Tsilingiri
    Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
    Gut Microbes 3:442-8. 2012
    ..We used the new set-up to test three different Lactobacilli strains, none of which appeared to be benign on inflamed IBD mucosa...
  33. pmc The signaling adaptor Eps8 is an essential actin capping protein for dendritic cell migration
    Emanuela Frittoli
    IFOM, FIRC Institute of Molecular Oncology Foundation at IFOM IEO Campus, Via Adamello 16, 20139 Milan, Italy
    Immunity 35:388-99. 2011
    ..Yet, Eps8 is not necessary for antigen uptake, processing, and presentation. Thus, we have identified Eps8 as a unique actin capping protein specifically required for DC migration...
  34. doi Inactivation of junctional adhesion molecule-A enhances antitumoral immune response by promoting dendritic cell and T lymphocyte infiltration
    Masato Murakami
    FIRC Institute of Molecular Oncology, Milan, Italy
    Cancer Res 70:1759-65. 2010
    ..These findings support the idea that, in the Rip1Tag2 tumor model, abrogation of JAM-A reduces cancer development by increasing antitumor immune response...
  35. pmc R5 HIV-1 envelope attracts dendritic cells to cross the human intestinal epithelium and sample luminal virions via engagement of the CCR5
    Mariangela Cavarelli
    Unit of Viral Evolution and Transmission, DITID, San Raffaele Scientific Institute, Milan, Italy
    EMBO Mol Med 5:776-94. 2013
    ..Our findings indicate that HIV-1 translocation across the intestinal mucosa occurs through the selective engagement of DCs by R5 viruses, and may guide the design of new prevention strategies...
  36. ncbi Uptake and presentation of orally administered antigens
    Monica Rimoldi
    Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milano, Italy
    Vaccine 23:1793-6. 2005
    ....
  37. doi Host-bacteria interactions in the intestine: homeostasis to chronic inflammation
    Theolis Barbosa
    Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
    Wiley Interdiscip Rev Syst Biol Med 2:80-97. 2010
    ..In this review, we seek to collect the state-of-the-art knowledge about how host and microbiota interact to promote gut homeostasis and provide evidences of malfunctioning of the described mechanisms in human inflammatory bowel disease...
  38. ncbi Immunology and breast cancer: therapeutic cancer vaccines
    Giuseppe Curigliano
    Department of Medicine, Division of Medical Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milano, Italy
    Breast 16:S20-6. 2007
    ....
  39. pmc TLR4-mediated skin carcinogenesis is dependent on immune and radioresistant cells
    Deepak Mittal
    Department of Experimental Oncology, European Institute of Oncology, Milano, Italy
    EMBO J 29:2242-52. 2010
    ..Together, our results suggest that the initial release of HMGB1 triggers a TLR4-dependent inflammatory response that leads to tumour development...
  40. ncbi Novel Tn antigen-containing neoglycopeptides: synthesis and evaluation as anti tumor vaccines
    Laura Cipolla
    Department of Biotechnology and Biosciences, Universita degli Studi di Milano Bicocca, P za della Scienza 2, 20126, Milan, Italy
    Bioorg Med Chem 10:1639-46. 2002
    ..Neoglycopeptides 1--3 could be presented to and recognized by the T cell receptor; neoglycopeptide 3, bearing two B-epitopes, was presented to the TCR with higher efficiency, compared to neoglycopeptide 2, having only one B-epitope...
  41. doi Mucosal immunology and bacterial handling in the intestine
    Maria Rescigno
    Department of Experimental Oncology, European Institute of Oncology, Via Adamello, 16, 20139 Milan, Italy
    Best Pract Res Clin Gastroenterol 27:17-24. 2013
    ..When these two activities are not coordinated, inflammatory conditions may arise. In this review I will summarize the characteristic features of the mucosal immune system and its interaction with the microbiota...
  42. doi Vaccines in non-small cell lung cancer: rationale, combination strategies and update on clinical trials
    Tommaso De Pas
    Medical Oncology Unit of Respiratory Tract and Sarcomas, New Drugs Development Division, European Institute of Oncology, Milan, Italy
    Crit Rev Oncol Hematol 83:432-43. 2012
    ..We will review the key points for effective active immunotherapies and combination therapies, giving an update on the most promising vaccines developed in NSCLC...
  43. doi How the interplay between antigen presenting cells and microbiota tunes host immune responses in the gut
    Bartlomiej Swiatczak
    Scuola Europea di Medicina Molecolare, Milan, Italy
    Semin Immunol 24:43-9. 2012
    ..Here, we review how various functions of DCs depend on microbial stimuli and how these stimuli influence the course of immune activation...
  44. doi Intestinal dendritic cells
    Maria Rescigno
    Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
    Adv Immunol 107:109-38. 2010
    ....
  45. ncbi Entry route of Salmonella typhimurium directs the type of induced immune response
    Chiara Martinoli
    Department of Experimental Oncology, European Institute of Oncology, I 20124 Milan, Italy
    Immunity 27:975-84. 2007
    ..This compartmentalization could allow the fast generation of both mucosal and systemic acquired immunity to pathogens...
  46. ncbi Lactobacillus paracasei CBA L74 Metabolic Products and Fermented Milk for Infant Formula Have Anti-Inflammatory Activity on Dendritic Cells In Vitro and Protective Effects against Colitis and an Enteric Pathogen In Vivo
    Elena Zagato
    Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
    PLoS ONE 9:e87615. 2014
    ..paracasei CBA L74 fermented formula can provide immune benefits to formula-fed infants, without carrying live bacteria that may be potentially dangerous to an immature infant immune system. ..
  47. doi Plasmacytoid DCs are gentle guardians of tonsillar epithelium
    Maria Rescigno
    Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
    Eur J Immunol 43:1142-6. 2013
    ..These findings support a mechanism by which intraepithelial pDCs, which are exposed to the microbiota colonizing the upper respiratory tract, remain capable of initiating immunity without overreacting to microbial stimulation...
  48. doi Systemic features of immune recognition in the gut
    Bartlomiej Swiatczak
    Scuola Europea di Medicina Molecolare SEMM, Campus IFOM IEO, Via Adamello 16, 20139 Milan, Italy
    Microbes Infect 13:983-91. 2011
    ....
  49. doi Salmonella engineered to express CD20-targeting antibodies and a drug-converting enzyme can eradicate human lymphomas
    Paul E Massa
    European Institute of Oncology, Department of Experimental Oncology, Italian Foundation for Cancer Research Institute for Molecular Oncology, European Institute of Oncology Campus, Milan, Italy
    Blood 122:705-14. 2013
    ..Altogether, antibody-displaying Salmonella vectors can mediate a tumor-specific response and rejection with few detectable adverse effects while specifically delivering cytotoxic payloads...
  50. ncbi What is new in melanoma research? Vaccines, Basic and Translational Research in 2003: report of a workshop at the Third Research Meeting on Melanoma, Milan, Italy, May 2003
    Maria Rescigno
    Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
    Melanoma Res 14:241-3. 2004
    ..This report briefly summarizes some of the highlights and themes of this session...
  51. ncbi Dendritic cells and the complexity of microbial infection
    Maria Rescigno
    Dept of Experimental Oncology, European Institute of Oncology, Via Ripamonti, 435, 20141, Milano, Italy
    Trends Microbiol 10:425-61. 2002
    ..These interactions can determine the success or failure of the immune response induced against pathogens...
  52. pmc The biology of intestinal immunoglobulin A responses
    Andrea Cerutti
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, and Weill Graduate School of Medical Sciences of Cornell University, 1300 York Avenue, New York, NY 10065, USA
    Immunity 28:740-50. 2008
    ..Here we discuss the role of intestinal IgA in host-commensal mutualism, immune protection, and tolerance and summarize recent advances on the role of innate immune cells in intestinal IgA production...
  53. ncbi Mucosal dendritic cells in immunity and inflammation
    Brian L Kelsall
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 5:1091-5. 2004
  54. ncbi Gut-level decisions in peace and war
    Maria Rescigno
    Nat Med 11:254-5. 2005
  55. ncbi The role of molecular imaging in the development of dendritic cell-based cancer vaccines
    Giovanni Lucignani
    Eur J Nucl Med Mol Imaging 32:725-30. 2005
  56. ncbi Intestinal bacteria trigger T cell-independent immunoglobulin A(2) class switching by inducing epithelial-cell secretion of the cytokine APRIL
    Bing He
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Immunity 26:812-26. 2007
    ..Thus, mucosal vaccines should activate IECs to induce more effective IgA(2) responses...
  57. doi Unique role of junctional adhesion molecule-a in maintaining mucosal homeostasis in inflammatory bowel disease
    Stefania Vetrano
    Division of Gastroenterology, Istituto di Ricerca e Cura a Carattere Scientifico Istituto Clinico Humanitas, University of Milan, Rozzano, Italy
    Gastroenterology 135:173-84. 2008
    ..Junctional adhesion molecule-A (JAM-A) is localized at the tight junctions and controls leukocyte migration into the tissues. However, its functional role in inflammatory bowel disease (IBD) is unexplored...
  58. pmc Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement
    Marcello Chieppa
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 203:2841-52. 2006
    ..Collectively, these findings support a model in which epithelial cell TLR signaling upon exposure to microbial stimuli induces active DC sampling of the gut lumen at sites distant from organized lymphoid tissues...
  59. ncbi Molecular imaging of cell-mediated cancer immunotherapy
    Giovanni Lucignani
    Institute of Radiological Sciences, University of Milan, Via di Rudini 8, 20142 Milan, Italy
    Trends Biotechnol 24:410-8. 2006
    ..The general concepts of noninvasive imaging of targeted cells as well as the technology and probes applied to cell-mediated cancer immunotherapy imaging are outlined in this review...
  60. ncbi Toll-like receptor 4 is not required for the full maturation of dendritic cells or for the degradation of Gram-negative bacteria
    Maria Rescigno
    Department of Biotechnology and Bioscience, University of Milano Bicocca, Piazza della Scienza 2, I 20126 Milan, Italy
    Eur J Immunol 32:2800-6. 2002
    ..However, the bacteria killing property of BM-Mphi is completely restored by pretreating the cells with IFN-gamma. Hence, TLR4 plays different roles in DC versus Mphi...
  61. ncbi In vivo receptor-mediated delivery of a recombinant invasive bacterial toxoid to CD11c + CD8 alpha -CD11bhigh dendritic cells
    Pierre Guermonprez
    Unit of Biology of Immune Regulations, Institut Pasteur, Paris, France
    Eur J Immunol 32:3071-81. 2002
    ....