Research Topics
Genomes and Genes
| Simona PoloSummaryAffiliation: European Institute of Oncology Country: Italy Publications
| Collaborators
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Detail Information
Publications
Signaling-mediated control of ubiquitin ligases in endocytosisSimona Polo
IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139, Milan, Italy
BMC Biol 10:25. 2012....
Finding the right partner: science or ART?Simona Polo
IFOM, Istituto FIRC di Oncologia Molecolare, Milano, Italy
Cell 135:590-2. 2008....
Endocytosis conducts the cell signaling orchestraSimona Polo
IFOM, Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20134 Milan, Italy
Cell 124:897-900. 2006..In this way, endocytosis and cell signaling are intertwined in many biological processes, such as cell motility and cell fate determination...- Molecular mechanisms of coupled monoubiquitinationTanja Woelk
IFOM, The FIRC Institute for Molecular Oncology, Via Adamello 16, 20139, Milan, Italy
Nat Cell Biol 8:1246-54. 2006..Thus, our results clarify the mechanism of coupled monoubiquitination and identify the ubiquitination of E3 ligases as a critical determinant in this process... - Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradationSara Sigismund
IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139 Milan, Italy
Dev Cell 15:209-19. 2008..Thus, CME of the EGFR unexpectedly has a greater impact on receptor signaling than on receptor degradation... - Ubiquitin in trafficking: the network at workFilippo Acconcia
IFOM Foundation, The FIRC Institute for Molecular Oncology, Via Adamello 16, 20139 Milan, Italy
Exp Cell Res 315:1610-8. 2009..Here, we present an overview of ubiquitin's role as a 'signal' for intracellular trafficking and give examples of the multifaced mechanisms of ubiquitin-regulated RTK endocytosis... - EH and UIM: endocytosis and moreSimona Polo
Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139 Milan, Italy
Sci STKE 2003:re17. 2003..The focus of this review is to integrate available knowledge of the EH- and mUb networks with predictions of genetic and physical interactions stemming from functional genomics approaches... - Clathrin-independent endocytosis of ubiquitinated cargosSara Sigismund
Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139 Milan, Italy
Proc Natl Acad Sci U S A 102:2760-5. 2005..Thus, eps15s and epsin perform an important function in coupling ubiquitinated cargo to clathrin-independent internalization... - Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitinLorenza Penengo
IFOM, the FIRC Institute for Molecular Oncology Foundation, Via Adamello 16, 20139 Milan, Italy
Cell 124:1183-95. 2006..The two binding surfaces allow Ub to interact simultaneously with different UBDs, thus opening new perspectives in Ub-mediated signaling... - Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongationElena Maspero
IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Istituto Europeo di Oncologia, Via Adamello 16, Milan 20139, Italy
EMBO Rep 12:342-9. 2011..Mutational analysis highlights differences between the processes of substrate polyubiquitination and self-ubiquitination... - Characterization of human constitutive photomorphogenesis protein 1, a RING finger ubiquitin ligase that interacts with Jun transcription factors and modulates their transcriptional activityElisabetta Bianchi
Laboratory of Leukocyte Biology, DIBIT and Universita Vita Salute San Raffaele, Via Olgettina 58, 20132, Milan, Italy
J Biol Chem 278:19682-90. 2003..Our findings indicate that huCOP1 is a novel regulator of AP-1-dependent transcription sharing the important properties of Arabidopsis COP1 in the control of gene expression... - Endocytosis and signaling: cell logistics shape the eukaryotic cell planSara Sigismund
IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy
Physiol Rev 92:273-366. 2012.... - Proteomic snapshot of the EGF-induced ubiquitin networkElisabetta Argenzio
IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy
Mol Syst Biol 7:462. 2011.... - When ubiquitin meets ubiquitin receptors: a signalling connectionPier Paolo Di Fiore
Istituto Europeo di Oncologia, Via Ripamonti 435, 20141, Milan, Italy
Nat Rev Mol Cell Biol 4:491-7. 2003..We also put forward speculative models for the regulation of monoubiquitylation versus polyubiquitylation... - Endocytosis and cancerSimona Polo
IFOM, Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139, Milan, Italy
Curr Opin Cell Biol 16:156-61. 2004..Subversion of endocytic control is thus predicted to play a causative role in hyperproliferative conditions, first and foremost cancer... - Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processesMetello Innocenti
IFOM, Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20134, Milan, Italy
Nat Cell Biol 7:969-76. 2005..Thus, Abi1 is a dual regulator of WAVE and N-WASP activities in specific processes that are dependent on actin dynamics... - A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteinsSimona Polo
Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy
Nature 416:451-5. 2002..In addition, through their own ubiquitination, they may further contribute to the amplification of this network in the endocytic pathway... - Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradationKaisa Haglund
Ludwig Institute for Cancer Research, Husargatan 3, SE 75 124 Uppsala, Sweden
Nat Cell Biol 5:461-6. 2003..Thus, monoubiquitination is the principal signal responsible for the movement of RTKs from the plasma membrane to the lysosome... - N-WASP deficiency impairs EGF internalization and actin assembly at clathrin-coated pitsStefanie Benesch
Cytoskeleton Dynamics Group, German Research Centre for Biotechnology (GBF, Mascheroder Weg 1, 38124 Braunschweig, Germany
J Cell Sci 118:3103-15. 2005....