Simona Polo

Summary

Affiliation: European Institute of Oncology
Country: Italy

Publications

  1. pmc Signaling-mediated control of ubiquitin ligases in endocytosis
    Simona Polo
    IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139, Milan, Italy
    BMC Biol 10:25. 2012
  2. ncbi Endocytosis conducts the cell signaling orchestra
    Simona Polo
    IFOM, Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20134 Milan, Italy
    Cell 124:897-900. 2006
  3. doi Finding the right partner: science or ART?
    Simona Polo
    IFOM, Istituto FIRC di Oncologia Molecolare, Milano, Italy
    Cell 135:590-2. 2008
  4. ncbi Molecular mechanisms of coupled monoubiquitination
    Tanja Woelk
    IFOM, The FIRC Institute for Molecular Oncology, Via Adamello 16, 20139, Milan, Italy
    Nat Cell Biol 8:1246-54. 2006
  5. doi Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming
    Elena Maspero
    Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy
    Nat Struct Mol Biol 20:696-701. 2013
  6. doi Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradation
    Sara Sigismund
    IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139 Milan, Italy
    Dev Cell 15:209-19. 2008
  7. pmc Threshold-controlled ubiquitination of the EGFR directs receptor fate
    Sara Sigismund
    IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy
    EMBO J 32:2140-57. 2013
  8. ncbi EH and UIM: endocytosis and more
    Simona Polo
    Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139 Milan, Italy
    Sci STKE 2003:re17. 2003
  9. pmc Clathrin-independent endocytosis of ubiquitinated cargos
    Sara Sigismund
    Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139 Milan, Italy
    Proc Natl Acad Sci U S A 102:2760-5. 2005
  10. doi Ubiquitin in trafficking: the network at work
    Filippo Acconcia
    IFOM Foundation, The FIRC Institute for Molecular Oncology, Via Adamello 16, 20139 Milan, Italy
    Exp Cell Res 315:1610-8. 2009

Collaborators

Detail Information

Publications21

  1. pmc Signaling-mediated control of ubiquitin ligases in endocytosis
    Simona Polo
    IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139, Milan, Italy
    BMC Biol 10:25. 2012
    ....
  2. ncbi Endocytosis conducts the cell signaling orchestra
    Simona Polo
    IFOM, Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20134 Milan, Italy
    Cell 124:897-900. 2006
    ..In this way, endocytosis and cell signaling are intertwined in many biological processes, such as cell motility and cell fate determination...
  3. doi Finding the right partner: science or ART?
    Simona Polo
    IFOM, Istituto FIRC di Oncologia Molecolare, Milano, Italy
    Cell 135:590-2. 2008
    ....
  4. ncbi Molecular mechanisms of coupled monoubiquitination
    Tanja Woelk
    IFOM, The FIRC Institute for Molecular Oncology, Via Adamello 16, 20139, Milan, Italy
    Nat Cell Biol 8:1246-54. 2006
    ..Thus, our results clarify the mechanism of coupled monoubiquitination and identify the ubiquitination of E3 ligases as a critical determinant in this process...
  5. doi Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming
    Elena Maspero
    Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy
    Nat Struct Mol Biol 20:696-701. 2013
    ..We provide evidence that the Nedd4-family members are Lys63-specific enzymes whose catalysis is mediated by an essential C-terminal acidic residue...
  6. doi Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradation
    Sara Sigismund
    IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139 Milan, Italy
    Dev Cell 15:209-19. 2008
    ..Thus, CME of the EGFR unexpectedly has a greater impact on receptor signaling than on receptor degradation...
  7. pmc Threshold-controlled ubiquitination of the EGFR directs receptor fate
    Sara Sigismund
    IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy
    EMBO J 32:2140-57. 2013
    ..Since NCE controls the degradation of the EGFR, our findings have implications for how the cell responds to increasing levels of EGFR signalling, by varying the balance of receptor signalling and degradation/attenuation. ..
  8. ncbi EH and UIM: endocytosis and more
    Simona Polo
    Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139 Milan, Italy
    Sci STKE 2003:re17. 2003
    ..The focus of this review is to integrate available knowledge of the EH- and mUb networks with predictions of genetic and physical interactions stemming from functional genomics approaches...
  9. pmc Clathrin-independent endocytosis of ubiquitinated cargos
    Sara Sigismund
    Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139 Milan, Italy
    Proc Natl Acad Sci U S A 102:2760-5. 2005
    ..Thus, eps15s and epsin perform an important function in coupling ubiquitinated cargo to clathrin-independent internalization...
  10. doi Ubiquitin in trafficking: the network at work
    Filippo Acconcia
    IFOM Foundation, The FIRC Institute for Molecular Oncology, Via Adamello 16, 20139 Milan, Italy
    Exp Cell Res 315:1610-8. 2009
    ..Here, we present an overview of ubiquitin's role as a 'signal' for intracellular trafficking and give examples of the multifaced mechanisms of ubiquitin-regulated RTK endocytosis...
  11. ncbi Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin
    Lorenza Penengo
    IFOM, the FIRC Institute for Molecular Oncology Foundation, Via Adamello 16, 20139 Milan, Italy
    Cell 124:1183-95. 2006
    ..The two binding surfaces allow Ub to interact simultaneously with different UBDs, thus opening new perspectives in Ub-mediated signaling...
  12. pmc Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation
    Elena Maspero
    IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Istituto Europeo di Oncologia, Via Adamello 16, Milan 20139, Italy
    EMBO Rep 12:342-9. 2011
    ..Mutational analysis highlights differences between the processes of substrate polyubiquitination and self-ubiquitination...
  13. ncbi Characterization of human constitutive photomorphogenesis protein 1, a RING finger ubiquitin ligase that interacts with Jun transcription factors and modulates their transcriptional activity
    Elisabetta Bianchi
    Laboratory of Leukocyte Biology, DIBIT and Universita Vita Salute San Raffaele, Via Olgettina 58, 20132, Milan, Italy
    J Biol Chem 278:19682-90. 2003
    ..Our findings indicate that huCOP1 is a novel regulator of AP-1-dependent transcription sharing the important properties of Arabidopsis COP1 in the control of gene expression...
  14. pmc Proteomic snapshot of the EGF-induced ubiquitin network
    Elisabetta Argenzio
    IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy
    Mol Syst Biol 7:462. 2011
    ....
  15. doi Endocytosis and signaling: cell logistics shape the eukaryotic cell plan
    Sara Sigismund
    IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy
    Physiol Rev 92:273-366. 2012
    ....
  16. ncbi When ubiquitin meets ubiquitin receptors: a signalling connection
    Pier Paolo Di Fiore
    Istituto Europeo di Oncologia, Via Ripamonti 435, 20141, Milan, Italy
    Nat Rev Mol Cell Biol 4:491-7. 2003
    ..We also put forward speculative models for the regulation of monoubiquitylation versus polyubiquitylation...
  17. ncbi Endocytosis and cancer
    Simona Polo
    IFOM, Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139, Milan, Italy
    Curr Opin Cell Biol 16:156-61. 2004
    ..Subversion of endocytic control is thus predicted to play a causative role in hyperproliferative conditions, first and foremost cancer...
  18. ncbi Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes
    Metello Innocenti
    IFOM, Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20134, Milan, Italy
    Nat Cell Biol 7:969-76. 2005
    ..Thus, Abi1 is a dual regulator of WAVE and N-WASP activities in specific processes that are dependent on actin dynamics...
  19. ncbi A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins
    Simona Polo
    Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy
    Nature 416:451-5. 2002
    ..In addition, through their own ubiquitination, they may further contribute to the amplification of this network in the endocytic pathway...
  20. ncbi Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation
    Kaisa Haglund
    Ludwig Institute for Cancer Research, Husargatan 3, SE 75 124 Uppsala, Sweden
    Nat Cell Biol 5:461-6. 2003
    ..Thus, monoubiquitination is the principal signal responsible for the movement of RTKs from the plasma membrane to the lysosome...
  21. ncbi N-WASP deficiency impairs EGF internalization and actin assembly at clathrin-coated pits
    Stefanie Benesch
    Cytoskeleton Dynamics Group, German Research Centre for Biotechnology GBF, Mascheroder Weg 1, 38124 Braunschweig, Germany
    J Cell Sci 118:3103-15. 2005
    ....