G Pelosi

Summary

Affiliation: European Institute of Oncology
Country: Italy

Publications

  1. ncbi Successful chemotherapy and 90Y-DOTATOC in a patient with mediastinal highly aggressive neuroendocrine carcinoma
    Nicola Fazio
    Acta Oncol 45:627-9. 2006
  2. ncbi The classification of lung carcinoma: time to change the morphology-based approach?
    Giuseppe Pelosi
    Divisione di Anatomia Patologica e Medicina di Laboratorio, European Institute of Oncology, Milan, Italy
    Int J Surg Pathol 18:161-72. 2010
  3. ncbi CD117 immunoreactivity in stage I adenocarcinoma and squamous cell carcinoma of the lung: relevance to prognosis in a subset of adenocarcinoma patients
    Giuseppe Pelosi
    Department of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
    Mod Pathol 17:711-21. 2004
  4. ncbi Lack of prognostic implications of HER-2/neu abnormalities in 345 stage I non-small cell carcinomas (NSCLC) and 207 stage I-III neuroendocrine tumours (NET) of the lung
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
    Int J Cancer 113:101-8. 2005
  5. ncbi Typical and atypical pulmonary carcinoid tumor overdiagnosed as small-cell carcinoma on biopsy specimens: a major pitfall in the management of lung cancer patients
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology, University of Milan School of Medicine, Milan, Italy
    Am J Surg Pathol 29:179-87. 2005
  6. ncbi Alteration of the E-cadherin/beta-catenin cell adhesion system is common in pulmonary neuroendocrine tumors and is an independent predictor of lymph node metastasis in atypical carcinoids
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology, University of Milan School of Medicine, Milan, Italy
    Cancer 103:1154-64. 2005
  7. ncbi 3q26 Amplification and polysomy of chromosome 3 in squamous cell lesions of the lung: a fluorescence in situ hybridization study
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology, University of Milan School of Medicine and Cancer Genetic Unit, IFOM Foundation FIRC Institute of Molecular Oncology Foundation, Milan, Italy
    Clin Cancer Res 13:1995-2004. 2007
  8. ncbi Detecting cell-free circulating hTERT mRNA in the plasma may identify a subset of nonsmall cell lung cancer patients
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
    Virchows Arch 448:7-15. 2006
  9. ncbi Salivary gland-type tumors with myoepithelial differentiation arising in pulmonary hamartoma: report of 2 cases of a hitherto unrecognized association
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
    Am J Surg Pathol 30:375-87. 2006
  10. ncbi Immunoreactivity for sex steroid hormone receptors in pulmonary hamartomas
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Voa G Ripamonti 435, I 20141 Milan, Italy
    Am J Surg Pathol 30:819-27. 2006

Detail Information

Publications98

  1. ncbi Successful chemotherapy and 90Y-DOTATOC in a patient with mediastinal highly aggressive neuroendocrine carcinoma
    Nicola Fazio
    Acta Oncol 45:627-9. 2006
  2. ncbi The classification of lung carcinoma: time to change the morphology-based approach?
    Giuseppe Pelosi
    Divisione di Anatomia Patologica e Medicina di Laboratorio, European Institute of Oncology, Milan, Italy
    Int J Surg Pathol 18:161-72. 2010
    ....
  3. ncbi CD117 immunoreactivity in stage I adenocarcinoma and squamous cell carcinoma of the lung: relevance to prognosis in a subset of adenocarcinoma patients
    Giuseppe Pelosi
    Department of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
    Mod Pathol 17:711-21. 2004
    ..Targeting the CD117 pathway could be a novel therapeutic strategy in a subset of pulmonary carcinomas...
  4. ncbi Lack of prognostic implications of HER-2/neu abnormalities in 345 stage I non-small cell carcinomas (NSCLC) and 207 stage I-III neuroendocrine tumours (NET) of the lung
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
    Int J Cancer 113:101-8. 2005
    ..Among neuroendocrine tumours, LCNEC show a slightly higher prevalence of either HER-2/neu gene amplification or protein overexpression...
  5. ncbi Typical and atypical pulmonary carcinoid tumor overdiagnosed as small-cell carcinoma on biopsy specimens: a major pitfall in the management of lung cancer patients
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology, University of Milan School of Medicine, Milan, Italy
    Am J Surg Pathol 29:179-87. 2005
    ....
  6. ncbi Alteration of the E-cadherin/beta-catenin cell adhesion system is common in pulmonary neuroendocrine tumors and is an independent predictor of lymph node metastasis in atypical carcinoids
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology, University of Milan School of Medicine, Milan, Italy
    Cancer 103:1154-64. 2005
    ..To the authors' knowledge, little is known regarding the role of E-cadherin/beta-catenin system dysregulation in pulmonary neuroendocrine tumors...
  7. ncbi 3q26 Amplification and polysomy of chromosome 3 in squamous cell lesions of the lung: a fluorescence in situ hybridization study
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology, University of Milan School of Medicine and Cancer Genetic Unit, IFOM Foundation FIRC Institute of Molecular Oncology Foundation, Milan, Italy
    Clin Cancer Res 13:1995-2004. 2007
    ....
  8. ncbi Detecting cell-free circulating hTERT mRNA in the plasma may identify a subset of nonsmall cell lung cancer patients
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
    Virchows Arch 448:7-15. 2006
    ..It can be added to the panel of multiple genetic tracers to detect lung cancer in the plasma of patients, although, per se, it is not specific for this tumor...
  9. ncbi Salivary gland-type tumors with myoepithelial differentiation arising in pulmonary hamartoma: report of 2 cases of a hitherto unrecognized association
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
    Am J Surg Pathol 30:375-87. 2006
    ....
  10. ncbi Immunoreactivity for sex steroid hormone receptors in pulmonary hamartomas
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Voa G Ripamonti 435, I 20141 Milan, Italy
    Am J Surg Pathol 30:819-27. 2006
    ..In conclusion, sex steroid hormone receptor expression is a nonrandom event in pulmonary hamartoma, and may be related to the development and growth of this tumor...
  11. ncbi A primary pure yolk sac tumor of the lung exhibiting CDX-2 immunoreactivity and increased serum levels of alkaline phosphatase intestinal isoenzyme
    Giuseppe Pelosi
    Division of Pathology, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
    Int J Surg Pathol 14:247-51. 2006
    ..The pathologist should be aware of yolk sac tumor arising in the lung and that alkaline phosphatase intestinal isoform could become an additional serum marker for such a tumor...
  12. ncbi Peptide receptors in neuroendocrine tumors of the lung as potential tools for radionuclide diagnosis and therapy
    G Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology, University of Milan School of Medicine, Milan, Italy
    Q J Nucl Med Mol Imaging 50:272-87. 2006
    ....
  13. ncbi Invited commentary
    Giuseppe Pelosi
    Istituto Europeo di Oncologia, Via G Ripamonti 435, Milan, I-20141 Italy
    Ann Thorac Surg 83:214-5. 2007
  14. ncbi Decreased immunoreactivity of CD99 is an independent predictor of regional lymph node metastases in pulmonary carcinoid tumors
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology, Milan, Italy
    J Thorac Oncol 1:468-77. 2006
    ..Few data are available on the prevalence and clinicopathological meaning of CD99, the transmembrane product of the pseudoautosomal MIC2 gene, in pulmonary neuroendocrine tumors...
  15. ncbi Images in pathology. Benign hyperplastic mesothelial cells in lymph node
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
    Int J Surg Pathol 15:297-9. 2007
  16. ncbi Intravascular papillary endothelial hyperplasia of the renal vein
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
    Int J Surg Pathol 19:518-20. 2011
    ....
  17. ncbi Pathologic and molecular features of screening low-dose computed tomography (LDCT)-detected lung cancer: a baseline and 2-year repeat study
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology, Milan, Italy
    Lung Cancer 62:202-14. 2008
    ..Repeat cancers are potentially aggressive tumors. K-ras mutation analysis supports the impression that multifocal tumors at baseline are separate synchronous primaries...
  18. ncbi Invited commentary
    Giuseppe Pelosi
    , Via G. Ripamonti, 435, Milan, Italy
    Ann Thorac Surg 86:1090-1. 2008
  19. ncbi Review article: pulmonary sarcomatoid carcinomas: a practical overview
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, University of Milan School of Medicine, Milan
    Int J Surg Pathol 18:103-20. 2010
    ..Conceivably, targeting the epithelial-mesenchymal transition program could become a valid therapeutic strategy for these life-threatening tumors, whose sensitivity to current medical manipulation is disappointing...
  20. ncbi K-ras gene mutational analysis supports a monoclonal origin of biphasic pleomorphic carcinoma of the lung
    Giuseppe Pelosi
    Department of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
    Mod Pathol 17:538-46. 2004
    ....
  21. ncbi Pulmonary epithelial-myoepithelial tumor of unproven malignant potential: report of a case and review of the literature
    G Pelosi
    Department of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Italy
    Mod Pathol 14:521-6. 2001
    ..In addition, we first introduce p63 as a novel marker for highlighting the myoepithelial cells of the respiratory tract and speculate on the role of these cells in the development of this unusual tumor...
  22. ncbi Immunoreactivity for thyroid transcription factor-1 in stage I non-small cell carcinomas of the lung
    G Pelosi
    Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
    Am J Surg Pathol 25:363-72. 2001
    ..Our findings suggest that TTF-1 could be involved in the development of small pulmonary adenocarcinomas, but it has not prognostic implications in patients with stage I NSCLC...
  23. ncbi Progesterone receptor immunoreactivity in minute meningothelioid nodules of the lung
    Giuseppe Pelosi
    Department of Pathology and Laboratory Medicine, European Institute of Oncology, University of Milan School of Medicine, Via G Ripamonti 435, 20141 Milan, Italy
    Virchows Arch 440:543-6. 2002
    ..This finding corroborates the view that these proliferations exhibit arachnoid cell-like differentiation and suggests a role for sex-steroid hormones in the control of their growth...
  24. ncbi CD117 immunoreactivity in high-grade neuroendocrine tumors of the lung: a comparative study of 39 large-cell neuroendocrine carcinomas and 27 surgically resected small-cell carcinomas
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology, Via G Ripamonti 435, 20141 Milan, Italy
    Virchows Arch 445:449-55. 2004
    ..There was no association between CD117 immunoreactivity and survival in either small-cell carcinoma or large-cell neuroendocrine carcinoma patients...
  25. ncbi Pleomorphic carcinomas of the lung show a selective distribution of gene products involved in cell differentiation, cell cycle control, tumor growth, and tumor cell motility: a clinicopathologic and immunohistochemical study of 31 cases
    Giuseppe Pelosi
    Department of Pathology and Laboratory Medicine, Institute of European Oncology and University of Milan School of Medicine, Italy
    Am J Surg Pathol 27:1203-15. 2003
    ....
  26. ncbi p63 immunoreactivity in lung cancer: yet another player in the development of squamous cell carcinomas?
    Giuseppe Pelosi
    Department of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
    J Pathol 198:100-9. 2002
    ..Although p63 is likely to be involved in the development of pulmonary squamous cell carcinoma, it does not carry any prognostic implication for NSCLC patients...
  27. ncbi Prognostic implications of neuroendocrine differentiation and hormone production in patients with Stage I nonsmall cell lung carcinoma
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
    Cancer 97:2487-97. 2003
    ..However, little is known regarding the prevalence and clinical implications of NE differentiation in patients with Stage I NSCLC...
  28. ncbi CD99 immunoreactivity in gastrointestinal and pulmonary neuroendocrine tumours
    G Pelosi
    Divisione di Anatomia Patologica e Medicina di Laboratorio, Istituto Europeo di Oncologia, Milano, Italy
    Virchows Arch 437:270-4. 2000
    ....
  29. ncbi Fluorodeoxyglucose positron emission tomography improves preoperative staging of resectable lung metastasis
    U Pastorino
    Department of Thoracic Surgery, Istituto Nazionale Tumori, Milan, Italy
    J Thorac Cardiovasc Surg 126:1906-10. 2003
    ..This study evaluated the role of PET in the preoperative assessment of resectable lung metastases...
  30. ncbi Expression of gemcitabine- and cisplatin-related genes in non-small-cell lung cancer
    F Toffalorio
    Clinical Pharmacology and New Drug Development Unit, European Institute of Oncology, Milan, Italy
    Pharmacogenomics J 10:180-90. 2010
    ..These data suggest a similar genetic susceptibility to gemcitabine-cisplatin regimens for squamous cell and adenocarcinoma and support the use of both lymph node and primary tumor for the expression profiling of NSCLC...
  31. ncbi Independent prognostic value of fascin immunoreactivity in stage I nonsmall cell lung cancer
    G Pelosi
    Department of Pathology and Laboratory Medicine, University of Milan School of Medicine, Italy
    Br J Cancer 88:537-47. 2003
    ..Targetting the fascin pathway could be a novel therapeutic strategy of NSCLC...
  32. ncbi Independent prognostic value of fascin immunoreactivity in stage III-IV colonic adenocarcinoma
    G Puppa
    Division of Pathology, CRO National Cancer Institute, Aviano, Italy
    Br J Cancer 96:1118-26. 2007
    ..Our findings suggest that fascin is a useful prognostic marker for colonic adenocarcinomas...
  33. ncbi Fluoro-deoxi-glucose uptake and angiogenesis are independent biological features in lung metastases
    G Veronesi
    Department of Thoracic Surgery, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Br J Cancer 86:1391-5. 2002
    ..Glucose uptake and angiogenesis appear to be independent biological features in lung metastasis. This observation may have implications for future antiangiogenic therapies...
  34. ncbi Early lung-cancer detection with spiral CT and positron emission tomography in heavy smokers: 2-year results
    Ugo Pastorino
    Division of Thoracic Surgery, Istituto Nazionale Tumori, Milan, Italy
    Lancet 362:593-7. 2003
    ..We investigated the efficacy of repeated yearly spiral CT and selective use of positron emission tomography (PET) in a large cohort of high-risk volunteers...
  35. ncbi Imaging of lung hamartomas by multidetector computed tomography and positron emission tomography
    Concetta De Cicco
    Division of Nuclear Medicine, European Institute of Oncology, Milan, Italy
    Ann Thorac Surg 86:1769-72. 2008
    ..Most are discovered on routine x-ray film and require further evaluation. Computed tomography (CT) is insufficient for a benign versus malignant diagnosis in about 30% of cases...
  36. ncbi Low morbidity of bronchoplastic procedures after chemotherapy for lung cancer
    G Veronesi
    Division of Thoracic Surgery, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Lung Cancer 36:91-7. 2002
    ..To evaluate if induction chemotherapy, with or without irradiation, represents an additional risk factor for early and late morbidity and perioperative mortality in bronchoplastic procedures for lung cancers...
  37. ncbi Immunocytochemical assessment of bone marrow aspirates for monitoring response to chemotherapy in small-cell lung cancer patients
    G Pelosi
    Department of Pathology and Laboratory Medicine, European Institute of Oncology, Milan, Italy
    Br J Cancer 81:1213-21. 1999
    ....
  38. ncbi Genomic characterization of asymptomatic CT-detected lung cancers
    E Belloni
    Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
    Oncogene 30:1117-26. 2011
    ....
  39. ncbi A subset of high-grade pulmonary neuroendocrine carcinomas shows up-regulation of matrix metalloproteinase-7 associated with nuclear beta-catenin immunoreactivity, independent of EGFR and HER-2 gene amplification or expression
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
    Virchows Arch 447:969-77. 2005
    ..A minor subset of these tumors shows beta-catenin nuclear accumulation in association with increased expression of MMP-7, but not of cyclin D1, independent of EGFR and HER-2 gene amplification or expression...
  40. ncbi Alterations of the Notch pathway in lung cancer
    Britta Westhoff
    IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy
    Proc Natl Acad Sci U S A 106:22293-8. 2009
    ..Our results show that the deregulation of the Notch pathway is a relatively frequent event in NSCLCs and suggest that it might represent a possible target for molecular therapies in these tumors...
  41. ncbi Quantification of free circulating DNA as a diagnostic marker in lung cancer
    Gabriella Sozzi
    Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy
    J Clin Oncol 21:3902-8. 2003
    ..Levels of plasma DNA could also identify higher-risk individuals for lung cancer screening and chemoprevention trials...
  42. ncbi Dual role of RASSF1 as a tumor suppressor and an oncogene in neuroendocrine tumors of the lung
    Giuseppe Pelosi
    Division of Pathology and Laboratory MedicineEuropean Institute of Oncology and National Cancer Institute, Milan, Italy
    Anticancer Res 30:4269-81. 2010
    ..Little is known about the dual role of RAS-association domain family 1 (RASSF1) gene at 3p21.3 in neuroendocrine tumors (NET) of the lung...
  43. ncbi Synchronous pleuro - renal solitary fibrous tumors: a new clinical-pathological finding
    F Petrella
    Department of Thoracic Surgery, European Institute of Oncology, Milan, Italy
    Minerva Chir 64:669-71. 2009
    ..After a one-year follow-up no recurrence was detected in the left hemithorax and the renal lesion remained stable...
  44. ncbi Images in pathology: micronodular epithelial hyperplasia in ectopic thymus
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
    Int J Surg Pathol 14:73-4. 2006
  45. ncbi Randomized biomarker trial of anastrozole or low-dose tamoxifen or their combination in subjects with breast intraepithelial neoplasia
    Bernardo Bonanni
    Divisions of Cancer Prevention and Genetics, European Institute of Oncology, Milan, University of Milan School of Medicine, Milan, Italy
    Clin Cancer Res 15:7053-60. 2009
    ..The influence of CYP2D6 genotype on tamoxifen effects was also determined...
  46. ncbi Alterations of ubiquitin ligases in human cancer and their association with the natural history of the tumor
    S Confalonieri
    IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy
    Oncogene 28:2959-68. 2009
    ..Our findings show that the alteration of Ub ligases is a frequent event in cancer and identify candidate targets for molecular therapies...
  47. ncbi Genetic alterations in combined neuroendocrine neoplasms of the lung
    Tiziana D'Adda
    Department of Pathology and Laboratory Medicine, Section of Pathological Anatomy, University of Parma, Parma, Italy
    Mod Pathol 21:414-22. 2008
    ..The genetic differences observed provide the basis for the divergent differentiation and parallel the morphological differences in the two components of these combined neuroendocrine neoplasms...
  48. ncbi Tumour CEA as predictor of better outcome in squamous cell carcinoma of the lung
    Giulia Veronesi
    Thoracic Surgery Division, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Lung Cancer 48:233-40. 2005
    ..In SCC patients, the magnitude of the hazard ratio was confirmed even if the precision of the estimate is decreased (p=0.06). In conclusion, T-CEA expression appears to be an important prognostic factor in early stage SSC of the lung...
  49. ncbi Malignancy-associated X chromosome allelic losses in foregut endocrine neoplasms: further evidence from lung tumors
    Lorena Bottarelli
    Department of Pathology and Laboratory Medicine, Section of Pathological Anatomy, University of Parma, Parma, Italy
    Mod Pathol 18:795-805. 2005
    ....
  50. ncbi Sebaceous lymphadenoma of salivary gland: a case report and a review of the literature
    F Maffini
    Department of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan, School of Medicine, Milan, Italy
    Acta Otorhinolaryngol Ital 27:147-50. 2007
    ....
  51. ncbi Pathological assessment of pericolonic tumor deposits in advanced colonic carcinoma: relevance to prognosis and tumor staging
    Giacomo Puppa
    Division of Pathology, CRO National Cancer Institute, Aviano, Italy
    Mod Pathol 20:843-55. 2007
    ..Our findings suggest that pericolonic tumor deposits are a destructive type of venous invasion different from other types of vessel involvement, and that these lesions may rather be included in the M category for staging purposes...
  52. ncbi Randomized dose-ranging trial of tamoxifen at low doses in hormone replacement therapy users
    Andrea Decensi
    Division of Chemoprevention, European Institute of Oncology, Milan, Italy
    J Clin Oncol 25:4201-9. 2007
    ..We assessed the optimal biologic dose and schedule of tamoxifen in HRT users using surrogate end point biomarkers and menopausal symptoms...
  53. ncbi Adjuvant surgery after carboplatin and VP16 in resectable small cell lung cancer
    Giulia Veronesi
    Division of Thoracic Surgery, European Institute of Oncology, Milan, Italy
    J Thorac Oncol 2:131-4. 2007
    ....
  54. ncbi Randomized phase II trial of inhaled budesonide versus placebo in high-risk individuals with CT screen-detected lung nodules
    Giulia Veronesi
    Division of Thoracic Surgery, European Institute of Oncology, Via Ripamonti 435, I 20141 Milan, Italy
    Cancer Prev Res (Phila) 4:34-42. 2011
    ..There was a trend toward regression of nonsolid and partially solid nodules after budesonide treatment. Because a subset of these nodules is more likely to represent precursors of adenocarcinoma, additional follow-up is needed...
  55. ncbi Computer-assisted image analysis of breast fine needle aspiration in a randomized chemoprevention trial of fenretinide vs. placebo in HRT users
    Davide Serrano
    Division of Chemoprevention, European Institute of Oncology, Milan, Italy
    Breast 17:91-7. 2008
    ..Digital nuclear morphometric analysis can capture subtle differences along neoplastic progression. Studies showed different profiles from normal to cancer lesions. Our goal is to utilize this method as biomarker in chemoprevention trials...
  56. ncbi A critical appraisal of the adjuvant chemotherapy guidelines for patients with completely resected T3N0 non-small-cell lung cancer
    Tommaso De Pas
    New Drugs Development and Clinical Pharmacology Unit, Department of Medicine, European Institute of Oncology, Milan, Italy
    Acta Oncol 49:480-4. 2010
    ..However, these two tumor subgroups should be considered as different entities. While the efficacy of adjuvant chemotherapy has been established in patients with T1-2N1 NSCLC, its benefit in patients with T3N0 tumor remains questionable...
  57. ncbi Difficulties encountered managing nodules detected during a computed tomography lung cancer screening program
    Giulia Veronesi
    Department of Thoracic Surgery, European Institute of Oncology, Milan, Italy
    J Thorac Cardiovasc Surg 136:611-7. 2008
    ..We evaluated the pitfalls, difficulties, and sources of mistakes in the management of lung nodules detected in volunteers in the Cosmos single-center screening trial...
  58. ncbi Lung cancer screening with low-dose computed tomography: a non-invasive diagnostic protocol for baseline lung nodules
    Giulia Veronesi
    Department of Thoracic Surgery, European Institute of Oncology, Milan, Italy
    Lung Cancer 61:340-9. 2008
    ..We assessed the diagnostic utility of a non-invasive work-up protocol for nodules detected at baseline in volunteers enrolled in our single-centre screening trial, and followed for at least 1 year...
  59. ncbi Brief report: activity of imatinib in a patient with platelet-derived-growth-factor receptor positive malignant solitary fibrous tumor of the pleura
    Tommaso De Pas
    New Drugs Development Unit, European Institute of Oncology, Milan, Italy
    J Thorac Oncol 3:938-41. 2008
    ..Treatment with imatinib should be considered for patients with recurrent or unresectable MSFTs with PDGFR expression...
  60. ncbi Structural lung damage after chemotherapy fact or fiction?
    Francesco Leo
    Division of Thoracic Surgery, European Institute of Oncology, Via Ripamonti 435, 20100 Milan, Italy
    Lung Cancer 67:306-10. 2010
    ..The hypothesis of the study is that patients who received preoperative chemotherapy may have subclinical parenchymal damage, increasing their risk of respiratory complications...
  61. ncbi Role of positron emission tomography scanning in the management of lung nodules detected at baseline computed tomography screening
    Giulia Veronesi
    Department of Thoracic Surgery, European Institute of Oncology, Milan, Italy
    Ann Thorac Surg 84:959-65; discussion 965-6. 2007
    ..We present results using positron tomography scanning (CT-PET) to evaluate LD-CT-detected lung nodules during the first year of the Continuing Observation of Smoking Subjects (COSMOS) early detection trial for lung cancer...
  62. ncbi Prognostic role of lymph node involvement in lung metastasectomy
    Giulia Veronesi
    Division of Thoracic Surgery, European Institute of Oncology, Milan, Italy
    J Thorac Cardiovasc Surg 133:967-72. 2007
    ..We assessed the prognostic value of lymph node status in lung metastasectomy and the prevalence of unexpected mediastinal lymph node involvement after lymph node sampling or dissection...
  63. ncbi Extended pneumonectomy with partial resection of the left atrium, without cardiopulmonary bypass, for lung cancer
    Lorenzo Spaggiari
    Department of Thoracic Surgery European Institute of Oncology, Milan, Italy
    Ann Thorac Surg 79:234-40. 2005
    ..The present study analyzed a single center's experience with this extended surgery, highlighting the surgery's technical aspects, postoperative outcomes, and oncologic results...
  64. ncbi Large cell neuroendocrine carcinoma of the lung: a retrospective analysis of 144 surgical cases
    Giulia Veronesi
    Division of Thoracic Surgery, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Lung Cancer 53:111-5. 2006
    ..We retrospectively evaluated outcomes in a series of patients with a pathological diagnosis of large cell neuroendocrine lung carcinoma, who underwent lung resection. We also assessed the utility of chemotherapy in a small subgroup...
  65. ncbi Langerhans' cell histiocytosis
    Nicola Fazio
    European Institute of Oncology, 20141 Milan, Italy
    Lancet 365:598. 2005
  66. ncbi Independent value of fascin immunoreactivity for predicting lymph node metastases in typical and atypical pulmonary carcinoids
    Giuseppe Pelosi
    Department of Pathology and Laboratory Medicine, European Institute of Oncology, University of Milan School of Medicine, Via G Ripamonti, 435, I 20141 Milan, Italy
    Lung Cancer 42:203-13. 2003
    ..Targeting the fascin pathway could be a novel therapeutic strategy of pulmonary carcinoids...
  67. ncbi Erlotinib-induced breast cancer regression
    Chiara Catania
    Medical Care Unit, Department of Medicine, European Institute of Oncology, Milan, Italy
    Ann Pharmacother 40:2043-7. 2006
    ..To report a case of erlotinib-induced breast cancer regression...
  68. ncbi Detecting lung cancer in plasma with the use of multiple genetic markers
    Francesca Andriani
    Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy
    Int J Cancer 108:91-6. 2004
    ..2%) of stage I patients whose tumors had an alteration. These results provide the proof of principle that plasma DNA alterations are tumor-specific in most cases and support blood testing as a noninvasive strategy for early detection...
  69. ncbi Subclavicular recurrence of breast cancer: does surgery play a role?
    Giulia Veronesi
    Division of Thoracic Surgery, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Breast 15:649-53. 2006
    ..We conclude that the technique may be useful, in selected cases, for palliation only...
  70. ncbi Absence of epidermal growth factor receptor gene mutations in patients with hormone refractory prostate cancer not responding to gefitinib
    Giuseppe Curigliano
    Division of Medical Oncology, Clinical Pharmacology and New Drugs Development Unit, European Institute of Oncology and University of Milan School of Medicine, Milano, Italy
    Prostate 67:603-4. 2007
    ..To our knowledge no data have been reported on EGFR gene mutations in hormone refractory prostate cancer (HRPC)...
  71. ncbi Superior vena cava replacement for lung cancer using a heterologous (bovine) prosthesis: preliminary results
    Lorenzo Spaggiari
    Department of Thoracic Surgery, European Institute of Oncology, Milan, Italy
    J Thorac Cardiovasc Surg 131:490-1. 2006
  72. ncbi Results of chest wall resection for recurrent or locally advanced breast malignancies
    Giulia Veronesi
    Division of Thoracic Surgery, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Breast 16:297-302. 2007
    ....
  73. ncbi Modulation of epidermal growth factor receptor status by chemotherapy in patients with locally advanced non-small-cell lung cancer is rare
    Tommaso De Pas
    Division of Medical Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    J Clin Oncol 22:4966-70. 2004
    ....
  74. ncbi A randomized trial of low-dose tamoxifen on breast cancer proliferation and blood estrogenic biomarkers
    Andrea Decensi
    Division of Chemoprevention, European Institute of Oncology, and University of Milan School of Medicine, Milan, Italy
    J Natl Cancer Inst 95:779-90. 2003
    ....
  75. ncbi Long-term endoscopic and clinical follow-up of untreated type 1 gastric neuroendocrine tumours
    D Ravizza
    European Institute of Oncology, Division of Endoscopy, Via Ripamonti 435, Milan, Italy
    Dig Liver Dis 39:537-43. 2007
    ..Based on the favourable behaviour of this neoplasm, we performed an endoscopic and clinical follow-up in 11 patients affected by type 1 gastric neuroendocrine tumours, avoiding any specific treatment...
  76. ncbi Peptide receptor radiotherapy: a new option for the management of aggressive fibromatosis on behalf of the Italian Sarcoma Group
    T De Pas
    Division of Medical Oncology, European of Oncology, Via Ripamonti, Milan, Italy
    Br J Cancer 88:645-7. 2003
    ..We report on two patients with fast-growing recurrences of AF resistant to EBRT who obtained protracted clinical benefits with (90)Y-DOTATOC. (90)Y-DOTATOC should be further investigated in this setting...
  77. ncbi Preliminary results on safety and activity of a randomized, double-blind, 2 x 2 trial of low-dose tamoxifen and fenretinide for breast cancer prevention in premenopausal women
    Aliana Guerrieri-Gonzaga
    Division of Chemoprevention, European Institute of Oncology, Milan, Italy
    J Clin Oncol 24:129-35. 2006
    ..CONCLUSION: The combination of low-dose tamoxifen and fenretinide is safe but not synergistic in lowering IGF-I levels in premenopausal women. The clinical implications require further follow-up...
  78. ncbi Metastasis to the right stellate ganglion and vagal nerve: pathological alterations causing sudden death. A case report
    F Maffini
    Division of Pathology and Laboratory Medicine, European Institute of Oncology and
    Acta Otorhinolaryngol Ital 32:263-5. 2012
    ....
  79. ncbi Neuroendocrine tumour arising inside a retro-rectal tailgut cyst: report of two cases and a review of the literature
    F Spada
    Department of Medicine, European Institute of Oncology IEO, Milan, Italy
    Ecancermedicalscience 5:201. 2011
    ..We here describe two different clinical histories of well- and moderately differentiated neuroendocrine tumours (NETs) arising from tailgut cysts in the prerectal space together with a review of the relevant literature...
  80. ncbi Challenging diagnosis of an unusual solitary pulmonary nodule
    D Galetta
    Division of Thoracic Surgery, European Institute of Oncology, Milan, Italy
    Thorac Cardiovasc Surg 55:123-5. 2007
    ..It is important not to confuse these two diseases as this will prevent inappropriate medical treatment. Limited surgery is indicated for the treatment of these circumscribed lesions...
  81. ncbi Treatment of pulmonary metastases from primary intraosseous odontogenic carcinoma
    Domenico Galetta
    Division of Thoracic Surgery, European Institute of Oncology, Milan, Italy
    Lancet Oncol 7:272-3. 2006
  82. ncbi Pulsed dose-rate perioperative interstitial brachytherapy for soft tissue sarcomas of the extremities and skeletal muscles of the trunk
    Gianluca Lazzaro
    Melonoma Unit, European Institute of Oncology, University of Milan, Via Ripamonti 435, 20141 Milan, Italy
    Ann Surg Oncol 12:935-42. 2005
    ....
  83. ncbi Tumor deposits are encountered in advanced colorectal cancer and other adenocarcinomas: an expanded classification with implications for colorectal cancer staging system including a unifying concept of in-transit metastases
    Giacomo Puppa
    Division of Pathology, G Fracastoro City Hospital, Verona, Italy
    Mod Pathol 22:410-5. 2009
    ..Furthermore, we show that tumor deposits are not limited to colorectal cancer, but they are common to different adenocarcinoma types...
  84. ncbi Surgical 'damage control' treatment of a large retroperitoneal liposarcoma encasing a horseshoe kidney
    B Andreoni
    Department of General Surgery, European Institute of Oncology, Milan, Italy
    Ecancermedicalscience 2:77. 2008
    ..We report on the use of such therapeutic strategy in a patient affected by a retroperitoneal sarcoma concomitant to a horseshoe kidney, a relatively rare anatomical malformation...
  85. ncbi Mediastinal-like growing teratoma syndrome
    Giulia Veronesi
    Division of Thoracic Surgery, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    J Thorac Cardiovasc Surg 130:228-9. 2005
  86. ncbi Target-treatment and patients' selection: can we still neglect the timing of tissue collection?
    Tommaso De Pas
    J Clin Oncol 23:6274-5; author reply 6275-6. 2005
  87. ncbi Complex engagement of DNA damage response pathways in human cancer and in lung tumor progression
    Paolo Giovanni Nuciforo
    FIRC Institute of Molecular Oncology Foundation, Via Adamello 16, 20139 Milan, Italy
    Carcinogenesis 28:2082-8. 2007
    ....
  88. ncbi Expression of p63 in thymomas and normal thymus
    Jorge Dotto
    Department of Pathology, Yale New Haven Hospital, Yale University School of Medicine, New Haven, CT, USA
    Am J Clin Pathol 127:415-20. 2007
    ..All thymomas (including thymic carcinomas) were positive for p63 regardless of type. Most of the epithelial cells of the normal thymus were also positive for this marker...
  89. ncbi Late events and clinical prognostic factors in stage I non small cell lung cancer
    Felice Pasini
    Cattedra di Oncologia Medica, , Verona, Italy
    Lung Cancer 37:171-7. 2002
    ..In conclusion: this study found a non-negligible proportion of late events and identified some prognostic factors (PS, presence of symptoms and large cell histology) using information obtained from routine data...
  90. ncbi High-dose chemotherapy in small cell lung cancer
    Felice Pasini
    Cattedra di Oncologia Medica, , Italy
    Tumori 88:179-86. 2002
    ..Nowadays, some interest is emerging again due to the improvements in supportive care such as the availability of hematopoietic growth factors and the peripheral blood progenitor cells (PBPC)...
  91. ncbi Tamoxifen and metabolite concentrations in serum and breast cancer tissue during three dose regimens in a randomized preoperative trial
    Elton R Kisanga
    Hormone Laboratory, Haukeland University Hospital, Department of Medicine, and Centre for International Health, University of Bergen, Bergen, Norway
    Clin Cancer Res 10:2336-43. 2004
    ..Furthermore we studied tamoxifen effects on the cancer proliferation marker Ki-67, and on sex hormone-binding globulin (SHBG)...
  92. ncbi Lung cancers detected by screening with spiral computed tomography have a malignant phenotype when analyzed by cDNA microarray
    Fabrizio Bianchi
    Cancer Research UK Tumor Pathology Group, Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, United Kingdom
    Clin Cancer Res 10:6023-8. 2004
    ..Spiral computed tomography (CT) can detect lung cancer at an early stage, but the malignant potential is unknown. The question is, as follows: do these small lesions have the same lethal potential as do symptomatic tumors?..
  93. ncbi Immunohistochemical detection of HER1/HER2 can be considered a predictive marker of gefitinib activity in non-small-cell lung cancer?
    Cristina Noberasco
    J Clin Oncol 23:921-2; author reply 922. 2005
  94. ncbi Cetuximab for colorectal cancer
    Filippo Fraggetta
    N Engl J Med 358:1196; author reply 1196-7. 2008
  95. ncbi Microallelotyping defines the monoclonal or the polyclonal origin of mixed and collision endocrine-exocrine tumors of the gut
    Daniela Furlan
    Department of Clinical and Biological Sciences, University of Insubria, Varese, Italy
    Lab Invest 83:963-71. 2003
    ....
  96. ncbi Re: Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer
    Filippo De Braud
    J Natl Cancer Inst 97:461-2; author reply 462-3. 2005
  97. ncbi Expression of amino acid sequences of the chromogranin A molecule and synaptic vesicle protein 2 in neuroendocrine tumors of the lung
    Guida Maria Portela-Gomes
    Unit of Pathology, Department of Genetics and Pathology, University Hospital, 751 85 Uppsala, Sweden
    Virchows Arch 446:604-12. 2005
    ..The expression of CgA epitopes and SV2 occurs in all NE tumors, differing between better differentiated and poorly differentiated tumors but not within the respective groups...
  98. ncbi Frequent mutations in the neurotrophic tyrosine receptor kinase gene family in large cell neuroendocrine carcinoma of the lung
    Antonio Marchetti
    Clinical Research Center, Center of Excellence on Aging, University Foundation, Chieti, Italy
    Hum Mutat 29:609-16. 2008
    ..Such mutational events could represent an important step in the cancerogenesis of these tumors and may have potential implications for the selection of patients for targeted therapy...