Affiliation: European Institute of Oncology
Pelosi G, Fraggetta F, Pasini F, Maisonneuve P, Sonzogni A, Iannucci A, et al
. Immunoreactivity for thyroid transcription factor-1 in stage I non-small cell carcinomas of the lung. Am J Surg Pathol. 2001;25:363-72 pubmed
..Our findings suggest that TTF-1 could be involved in the development of small pulmonary adenocarcinomas, but it has not prognostic implications in patients with stage I NSCLC. ..
Pelosi G, Pasini F, Olsen Stenholm C, Pastorino U, Maisonneuve P, Sonzogni A, et al
. p63 immunoreactivity in lung cancer: yet another player in the development of squamous cell carcinomas?. J Pathol. 2002;198:100-9 pubmed
..Although p63 is likely to be involved in the development of pulmonary squamous cell carcinoma, it does not carry any prognostic implication for NSCLC patients. ..
Pelosi G, Pasini F, Sonzogni A, Maffini F, Maisonneuve P, Iannucci A, et al
. Prognostic implications of neuroendocrine differentiation and hormone production in patients with Stage I nonsmall cell lung carcinoma. Cancer. 2003;97:2487-97 pubmed
..Hormone production identifies a more fully developed neuroendocrine phenotype but is not relevant to prognosis. The identification of NE-differentiated cells in patients with NSCLC may have clinical relevance. ..
Pelosi G, Scarpa A, Manzotti M, Veronesi G, Spaggiari L, Fraggetta F, et al
. K-ras gene mutational analysis supports a monoclonal origin of biphasic pleomorphic carcinoma of the lung. Mod Pathol. 2004;17:538-46 pubmed
Pelosi G, Scarpa A, Puppa G, Veronesi G, Spaggiari L, Pasini F, et al
. Alteration of the E-cadherin/beta-catenin cell adhesion system is common in pulmonary neuroendocrine tumors and is an independent predictor of lymph node metastasis in atypical carcinoids. Cancer. 2005;103:1154-64 pubmed
..This likely affects the tumor growth pattern and cell motility of ACT and was correlated with the occurrence of lymph node metastases. ..
Pelosi G, Sonzogni A, De Pas T, Galetta D, Veronesi G, Spaggiari L, et al
. Review article: pulmonary sarcomatoid carcinomas: a practical overview. Int J Surg Pathol. 2010;18:103-20 pubmed publisher
..Conceivably, targeting the epithelial-mesenchymal transition program could become a valid therapeutic strategy for these life-threatening tumors, whose sensitivity to current medical manipulation is disappointing. ..
Pelosi G, Petrella F, Sandri M, Spaggiari L, Galetta D, Viale G. A primary pure yolk sac tumor of the lung exhibiting CDX-2 immunoreactivity and increased serum levels of alkaline phosphatase intestinal isoenzyme. Int J Surg Pathol. 2006;14:247-51 pubmed
..The pathologist should be aware of yolk sac tumor arising in the lung and that alkaline phosphatase intestinal isoform could become an additional serum marker for such a tumor. ..
Pelosi G, Fraggetta F, Maffini F, Solli P, Cavallon A, Viale G. Pulmonary epithelial-myoepithelial tumor of unproven malignant potential: report of a case and review of the literature. Mod Pathol. 2001;14:521-6 pubmed
..In addition, we first introduce p63 as a novel marker for highlighting the myoepithelial cells of the respiratory tract and speculate on the role of these cells in the development of this unusual tumor...
Pelosi G, Maffini F, Decarli N, Viale G. Progesterone receptor immunoreactivity in minute meningothelioid nodules of the lung. Virchows Arch. 2002;440:543-6 pubmed
..This finding corroborates the view that these proliferations exhibit arachnoid cell-like differentiation and suggests a role for sex-steroid hormones in the control of their growth. ..