M Pasparakis

Summary

Affiliation: European Molecular Biology Laboratory
Country: Italy

Publications

  1. ncbi request reprint Dissection of the NF-kappaB signalling cascade in transgenic and knockout mice
    M Pasparakis
    European Molecular Biology Laboratory, Mouse Biology Unit, Via Ramarini 32, Monterotondo Scalo, Rome 00016, Italy
    Cell Death Differ 13:861-72. 2006
  2. ncbi request reprint TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2
    Manolis Pasparakis
    Institute for Genetics, University of Cologne, Weyertal 121, D 50931 Cologne, Germany
    Nature 417:861-6. 2002
  3. ncbi request reprint NEMO/IKK gamma-deficient mice model incontinentia pigmenti
    M Schmidt-Supprian
    Institute for Genetics, University of Cologne, Federal Republic of Germany
    Mol Cell 5:981-92. 2000
  4. ncbi request reprint IKK/NF-kappaB signaling in intestinal epithelial cells controls immune homeostasis in the gut
    M Pasparakis
    Institute for Genetics, University of Cologne, Cologne, Germany
    Mucosal Immunol 1:S54-7. 2008
  5. pmc IkappaB kinase signaling is essential for maintenance of mature B cells
    Manolis Pasparakis
    Institute for Genetics, University of Cologne, D 50931 Cologne, Germany
    J Exp Med 196:743-52. 2002
  6. pmc Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation
    Athanasios Stratis
    Department of Dermatology and Center for Molecular Medicine, University of Cologne CMMC, Cologne, Germany
    J Clin Invest 116:2094-104. 2006
  7. ncbi request reprint Inhibition of transcription factor NF-kappaB in the central nervous system ameliorates autoimmune encephalomyelitis in mice
    Geert Van Loo
    European Molecular Biology Laboratory Mouse Biology Unit, I 00016 Monterotondo, Italy
    Nat Immunol 7:954-61. 2006
  8. pmc Targeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regeneration
    Foteini Mourkioti
    European Molecular Biology Laboratory EMBL Mouse Biology Unit, Campus A Buzzati Traverso, Monterotondo Scalo, Italy
    J Clin Invest 116:2945-54. 2006
  9. ncbi request reprint Deletion of NEMO/IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma
    Tom Luedde
    Institute for Genetics, University of Cologne, Zulpicher Strasse 47, 50674 Cologne, Germany
    Cancer Cell 11:119-32. 2007
  10. ncbi request reprint Normal epidermal differentiation but impaired skin-barrier formation upon keratinocyte-restricted IKK1 ablation
    Ralph Gareus
    Institute for Genetics, Department of Mouse Genetics and Inflammation, University of Cologne, Zülpicher Str 47, 50674 Cologne, Germany
    Nat Cell Biol 9:461-9. 2007

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Dissection of the NF-kappaB signalling cascade in transgenic and knockout mice
    M Pasparakis
    European Molecular Biology Laboratory, Mouse Biology Unit, Via Ramarini 32, Monterotondo Scalo, Rome 00016, Italy
    Cell Death Differ 13:861-72. 2006
    ..Furthermore, inhibition or enforced activation of NF-kappaB in transgenic mice has uncovered the critical roles that NF-kappaB plays in the pathogenesis of various diseases such as liver failure, diabetes and cancer...
  2. ncbi request reprint TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2
    Manolis Pasparakis
    Institute for Genetics, University of Cologne, Weyertal 121, D 50931 Cologne, Germany
    Nature 417:861-6. 2002
    ..Our results suggest that the critical function of IKK2-mediated NF-kappa B activity in epidermal keratinocytes is to regulate mechanisms that maintain the immune homeostasis of the skin...
  3. ncbi request reprint NEMO/IKK gamma-deficient mice model incontinentia pigmenti
    M Schmidt-Supprian
    Institute for Genetics, University of Cologne, Federal Republic of Germany
    Mol Cell 5:981-92. 2000
    ..Together with the recent discovery that mutations in the human NEMO gene cause IP, our results indicate that we have created a mouse model for that disease...
  4. ncbi request reprint IKK/NF-kappaB signaling in intestinal epithelial cells controls immune homeostasis in the gut
    M Pasparakis
    Institute for Genetics, University of Cologne, Cologne, Germany
    Mucosal Immunol 1:S54-7. 2008
    ..These findings identify IKK/NF-kappaB signaling in intestinal epithelial cells as an important factor for the maintenance of epithelial integrity and immune homeostasis in the gut...
  5. pmc IkappaB kinase signaling is essential for maintenance of mature B cells
    Manolis Pasparakis
    Institute for Genetics, University of Cologne, D 50931 Cologne, Germany
    J Exp Med 196:743-52. 2002
    ..We conclude that maintenance of mature B cells depends on IKK-mediated activation of NF-kappaB...
  6. pmc Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation
    Athanasios Stratis
    Department of Dermatology and Center for Molecular Medicine, University of Cologne CMMC, Cologne, Germany
    J Clin Invest 116:2094-104. 2006
    ....
  7. ncbi request reprint Inhibition of transcription factor NF-kappaB in the central nervous system ameliorates autoimmune encephalomyelitis in mice
    Geert Van Loo
    European Molecular Biology Laboratory Mouse Biology Unit, I 00016 Monterotondo, Italy
    Nat Immunol 7:954-61. 2006
    ..Thus, NF-kappaB-dependent gene expression in non-microglial cells of the CNS provides a permissive proinflammatory milieu that is critical for CNS inflammation and tissue damage in autoimmune demyelinating disease...
  8. pmc Targeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regeneration
    Foteini Mourkioti
    European Molecular Biology Laboratory EMBL Mouse Biology Unit, Campus A Buzzati Traverso, Monterotondo Scalo, Italy
    J Clin Invest 116:2945-54. 2006
    ..Our results establish IKK2/NF-kappaB signaling as an important modulator of muscle homeostasis and suggest a combined role for IKK inhibitors and growth factors in the therapy of muscle diseases...
  9. ncbi request reprint Deletion of NEMO/IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma
    Tom Luedde
    Institute for Genetics, University of Cologne, Zulpicher Strasse 47, 50674 Cologne, Germany
    Cancer Cell 11:119-32. 2007
    ....
  10. ncbi request reprint Normal epidermal differentiation but impaired skin-barrier formation upon keratinocyte-restricted IKK1 ablation
    Ralph Gareus
    Institute for Genetics, Department of Mouse Genetics and Inflammation, University of Cologne, Zülpicher Str 47, 50674 Cologne, Germany
    Nat Cell Biol 9:461-9. 2007
    ....
  11. pmc Hepatic NF-kappa B essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis
    F Thomas Wunderlich
    Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne and Center of Molecular Medicine Cologne, D 50674 Cologne, Germany
    Proc Natl Acad Sci U S A 105:1297-302. 2008
    ..These data directly demonstrate the interaction of hepatic inflammation, dietary composition, and metabolism in the development of liver tumorigenesis...
  12. pmc Defective osteoclastogenesis by IKKbeta-null precursors is a result of receptor activator of NF-kappaB ligand (RANKL)-induced JNK-dependent apoptosis and impaired differentiation
    Jesse E Otero
    Department of Orthedic Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 283:24546-53. 2008
    ..Our data highlight the pro-osteoclastogenic and anti-apoptotic roles of IKKbeta in OCPs and identify a pro-apoptotic mechanism activated within the RANK signalosome...
  13. pmc IKK1 and IKK2 cooperate to maintain bile duct integrity in the liver
    Tom Luedde
    Institute for Genetics, Centre for Molecular Medicine CMMC, and Cologne Excellence Cluster on Cellular Stress Responses in Aging associated Diseases CECAD, University of Cologne, Zulpicher Strasse 47, 50674 Cologne, Germany
    Proc Natl Acad Sci U S A 105:9733-8. 2008
    ..These results reveal a novel function of the two IkappaB kinases in cooperatively regulating liver immune homeostasis and bile duct integrity and suggest that IKK signaling may be implicated in human biliary diseases...
  14. ncbi request reprint Skin lesion development in a mouse model of incontinentia pigmenti is triggered by NEMO deficiency in epidermal keratinocytes and requires TNF signaling
    Arianna Nenci
    Mouse Biology Unit, European Molecular Biology Laboratory, Via Ramarini 32, 00016 Monterotondo Scalo, Rome, Italy
    Hum Mol Genet 15:531-42. 2006
    ..These results identify the NEMO-deficient keratinocyte as a potent initiator of skin inflammation and provide novel insights into the mechanism leading to the pathogenesis of IP...
  15. ncbi request reprint Localized inflammatory skin disease following inducible ablation of I kappa B kinase 2 in murine epidermis
    Athanasios Stratis
    Department of Dermatology, University of Cologne and Center for Molecular Medicine, University of Cologne CMMC, Cologne, Germany
    J Invest Dermatol 126:614-20. 2006
    ..Our results identify a primary role for IKK2 in the development of skin inflammation and confirm its requirement for the maintenance of skin homeostasis...
  16. pmc Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice
    Edwin Kanters
    Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Clin Invest 112:1176-85. 2003
    ..Our data show that inhibition of the NF-kappaB pathway in macrophages leads to more severe atherosclerosis in mice, possibly by affecting the pro- and anti-inflammatory balance that controls the development of atherosclerosis...
  17. pmc Conditional disruption of IkappaB kinase 2 fails to prevent obesity-induced insulin resistance
    Mathias Röhl
    Klinik II und Poliklinik für Innere Medizin der Universität zu Köln and Center for Molecular Medicine Cologne, Germany
    J Clin Invest 113:474-81. 2004
    ..These data argue against a substantial role for muscular IKK2 in mediating obesity-induced insulin resistance in these models in vivo...
  18. pmc Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation
    Marc Schmidt-Supprian
    CBR Institute for Biomedical Research, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:4566-71. 2004
    ..NKT cells, on the other hand, require PKCtheta for thymic development, whereas absence of Bcl10 leads primarily to the reduction of peripheral NKT cell numbers...
  19. ncbi request reprint Mature T cells depend on signaling through the IKK complex
    Marc Schmidt-Supprian
    Center for Blood Research, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Immunity 19:377-89. 2003
    ..Thus, IKK-induced NF-kappaB activation, mediated by either IKK1 or IKK2, is essential for the generation and survival of mature T cells, and IKK2 has an additional role in regulatory and memory T cell development...
  20. ncbi request reprint I kappa B kinase 2 deficiency in T cells leads to defects in priming, B cell help, germinal center reactions, and homeostatic expansion
    Marc Schmidt-Supprian
    CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 173:1612-9. 2004
    ..Finally, IKK2 is essential for homeostatic expansion of naive T cells, reflected by the inability of IKK2-deficient T cells to induce colitis in lymphopenic hosts...
  21. ncbi request reprint Genetically modified mice as a tool to study inflammatory skin diseases
    Ingo Haase
    Department of Dermatology and Centre for Molecular Medicine, University of Cologne CMMC, Joseph Stelzmann Strasse 9, 50924 Cologne, Germany
    J Dermatol 31:704-19. 2004
    ....
  22. pmc Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury
    Tom Luedde
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    J Clin Invest 115:849-59. 2005
    ....
  23. pmc Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases
    Sofia Xanthoulea
    Institute of Immunology, Biomedical Sciences Research Centre Al Fleming, 34 Al Fleming St, Vari 166 72, Greece
    J Exp Med 200:367-76. 2004
    ..Assessment of p55TNFR shedding may thus be of prognostic value in infectious, inflammatory, and autoimmune diseases...
  24. ncbi request reprint Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses
    Maria A Ermolaeva
    Institute for Genetics, Centre for Molecular Medicine, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, University of Cologne, 50674 Cologne, Germany
    Nat Immunol 9:1037-46. 2008
    ..Thus, TRADD is an essential component of TNFR1 signaling and has a critical but apparently cell type-specific function in TRIF-dependent TLR responses...
  25. ncbi request reprint FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses
    Panayiotis Victoratos
    Institute of Immunology, Biomedical Sciences Research Center Al Fleming, Vari 166 72, Greece
    Immunity 24:65-77. 2006
    ....
  26. ncbi request reprint IKK mediates ischemia-induced neuronal death
    Oliver Herrmann
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Nat Med 11:1322-9. 2005
    ..5 h. These data indicate a key function of IKK in ischemic brain damage and suggest a potential role for IKK inhibitors in stroke therapy...
  27. doi request reprint TRADD protein is an essential component of the RIG-like helicase antiviral pathway
    Marie Cecile Michallet
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Immunity 28:651-61. 2008
    ..Thus, TRADD is not only an essential component of proinflammatory TNFRI signaling, but is also required for RLH-Cardif-dependent antiviral immune responses...
  28. ncbi request reprint Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury
    Yumiko Imai
    IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohrgasse 3, A 1030 Vienna, Austria
    Cell 133:235-49. 2008
    ..Moreover, deletion of ncf1, which controls ROS production, improves the severity of H5N1-mediated ALI. Our data identify oxidative stress and innate immunity as key lung injury pathways that control the severity of ALI...
  29. pmc M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice
    Dominik Schenten
    CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
    Blood 107:4849-56. 2006
    ..Thus, M17 is dispensable for the GC reaction, and its potential function in the pathogenesis of DLBCL remains elusive...
  30. ncbi request reprint p38alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation
    Juan Jose Ventura
    CNIO Spanish National Cancer Center, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Nat Genet 39:750-8. 2007
    ..Our results indicate that by coordinating proliferation and differentiation signals in lung stem and progenitor cells, p38alpha has a key role in the regulation of lung cell renewal and tumorigenesis...
  31. ncbi request reprint Epithelial NEMO links innate immunity to chronic intestinal inflammation
    Arianna Nenci
    Institute for Genetics, University of Cologne, Zulpicher Strasse 47, 50674 Cologne, Germany
    Nature 446:557-61. 2007
    ....
  32. ncbi request reprint IKKbeta/2 induces TWEAK and apoptosis in mammary epithelial cells
    Fiona O Baxter
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Development 133:3485-94. 2006
    ..This unexpected function of the IKK2/NF-kappaB pathway as a regulator of TWEAK expression and inducer of apoptosis has significant consequences for future therapeutic approaches for cancer and inflammatory diseases...
  33. ncbi request reprint Keratin 14 Cre transgenic mice authenticate keratin 14 as an oocyte-expressed protein
    Martin Hafner
    Genesis 38:176-81. 2004
    ....