Marina C Mione

Summary

Affiliation: European Institute of Oncology
Country: Italy

Publications

  1. pmc The zebrafish as a model for cancer
    Marina C Mione
    IFOM Foundation FIRC Institute of Molecular Oncology Foundation, Via Adamello, Milan, Italy
    Dis Model Mech 3:517-23. 2010
  2. pmc The tumor suppressor PRDM5 regulates Wnt signaling at early stages of zebrafish development
    Natalia Meani
    Department on Experimental Oncology, European Institute of Oncology, Milan, Italy
    PLoS ONE 4:e4273. 2009
  3. pmc Live imaging of innate immune cell sensing of transformed cells in zebrafish larvae: parallels between tumor initiation and wound inflammation
    Yi Feng
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
    PLoS Biol 8:e1000562. 2010
  4. pmc Kita driven expression of oncogenic HRAS leads to early onset and highly penetrant melanoma in zebrafish
    Cristina Santoriello
    IFOM Foundation FIRC Institute of Molecular Oncology, Milan, Italy
    PLoS ONE 5:e15170. 2010
  5. ncbi Expression of pcp4a in subpopulations of CNS neurons in zebrafish
    Marina Mione
    Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
    J Comp Neurol 495:769-87. 2006
  6. ncbi How neuronal migration contributes to the morphogenesis of the CNS: insights from the zebrafish
    Marina Mione
    IFOM, FIRC Institute of Molecular Oncology, Milan, Italy
    Dev Neurosci 30:65-81. 2008
  7. ncbi Conserved and divergent patterns of Reelin expression in the zebrafish central nervous system
    Arianna Costagli
    Department of Anatomy and Developmental Biology, University College London, WC1E 6BT London, United Kingdom
    J Comp Neurol 450:73-93. 2002
  8. doi How to create the vascular tree? (Latest) help from the zebrafish
    Danila Baldessari
    IFOM IEO Campus FIRC Institute of Molecular Oncology Foundation European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy
    Pharmacol Ther 118:206-30. 2008
  9. pmc Identification of alternatively spliced dab1 isoforms in zebrafish
    Arianna Costagli
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK
    Dev Genes Evol 216:291-9. 2006
  10. pmc Stable vascular connections and remodeling require full expression of VE-cadherin in zebrafish embryos
    Mercedes Montero-Balaguer
    FIRC Institute of Molecular Oncology, Milan, Italy
    PLoS ONE 4:e5772. 2009

Collaborators

Detail Information

Publications23

  1. pmc The zebrafish as a model for cancer
    Marina C Mione
    IFOM Foundation FIRC Institute of Molecular Oncology Foundation, Via Adamello, Milan, Italy
    Dis Model Mech 3:517-23. 2010
    ..The overarching goal of the article is aimed at raising the awareness of basic researchers, as well as clinicians, to the versatility of this emerging alternative animal model of cancer...
  2. pmc The tumor suppressor PRDM5 regulates Wnt signaling at early stages of zebrafish development
    Natalia Meani
    Department on Experimental Oncology, European Institute of Oncology, Milan, Italy
    PLoS ONE 4:e4273. 2009
    ..Our data demonstrate that PRDM5 regulates the expression of components of both canonical and non canonical wnt pathways and negatively modulates wnt signaling in vivo...
  3. pmc Live imaging of innate immune cell sensing of transformed cells in zebrafish larvae: parallels between tumor initiation and wound inflammation
    Yi Feng
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
    PLoS Biol 8:e1000562. 2010
    ..These parallels between the inflammatory responses to transformed cells and to wounds reinforce the suggestion by others that cancers resemble non-healing wounds...
  4. pmc Kita driven expression of oncogenic HRAS leads to early onset and highly penetrant melanoma in zebrafish
    Cristina Santoriello
    IFOM Foundation FIRC Institute of Molecular Oncology, Milan, Italy
    PLoS ONE 5:e15170. 2010
    ..Because of the increasing incidence and high lethality of melanoma, animal models for continuously observing melanoma formation and progression as well as for testing pharmacological agents are needed...
  5. ncbi Expression of pcp4a in subpopulations of CNS neurons in zebrafish
    Marina Mione
    Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
    J Comp Neurol 495:769-87. 2006
    ..The analysis of pcp4a expression and localization in the zebrafish brain suggests that pcp4a may be a useful marker for sensory and some motor neuronal circuitries and for telencephalic areas processing sensory inputs...
  6. ncbi How neuronal migration contributes to the morphogenesis of the CNS: insights from the zebrafish
    Marina Mione
    IFOM, FIRC Institute of Molecular Oncology, Milan, Italy
    Dev Neurosci 30:65-81. 2008
    ..These examples reinforce the concept that migratory events contribute to the distribution of cell types with diverse identities through the CNS and that zebrafish transgenic lines represent excellent tools to study these events...
  7. ncbi Conserved and divergent patterns of Reelin expression in the zebrafish central nervous system
    Arianna Costagli
    Department of Anatomy and Developmental Biology, University College London, WC1E 6BT London, United Kingdom
    J Comp Neurol 450:73-93. 2002
    ..Thus, the differences in the telencephalic expression of reelin between teleosts and tetrapods are likely to be due to different roles for Reelin during eversion, a process that is specific for the teleost telencephalon...
  8. doi How to create the vascular tree? (Latest) help from the zebrafish
    Danila Baldessari
    IFOM IEO Campus FIRC Institute of Molecular Oncology Foundation European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy
    Pharmacol Ther 118:206-30. 2008
    ..This information contributes to the prospective of drug discovery to cure human diseases linked to angiogenesis, not last tumours...
  9. pmc Identification of alternatively spliced dab1 isoforms in zebrafish
    Arianna Costagli
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK
    Dev Genes Evol 216:291-9. 2006
    ....
  10. pmc Stable vascular connections and remodeling require full expression of VE-cadherin in zebrafish embryos
    Mercedes Montero-Balaguer
    FIRC Institute of Molecular Oncology, Milan, Italy
    PLoS ONE 4:e5772. 2009
    ..However, the mechanism of action of VE-cadherin is complex and, in the mouse embryo, it is difficult to define the specific steps of vascular development in which this protein is involved...
  11. doi Endocytic trafficking of Rac is required for the spatial restriction of signaling in cell migration
    Andrea Palamidessi
    IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139 Milan, Italy
    Cell 134:135-47. 2008
    ....
  12. ncbi Monoclonal antibodies isolated by large-scale screening are suitable for labeling adult zebrafish (Danio rerio) tissues and cell structures
    Gianluca Deflorian
    Fondazione IFOM Istituto FIRC di Oncologia Molecolare, Milan, Italy
    J Immunol Methods 346:9-17. 2009
    ..Such selection alternative is simpler to organize and could contribute to limit the costs of antibody screening and production...
  13. doi Global repression of cancer gene expression in a zebrafish model of melanoma is linked to epigenetic regulation
    Viviana Anelli
    IFOM Foundation FIRC Italian Foundation for Cancer Research Institute of Molecular Oncology, Milan, Italy
    Zebrafish 6:417-24. 2009
    ..Although the outcome of these changes is still unknown, they could be responsible for the global repression of gene expression through epigenetic regulation shown in this study...
  14. pmc Disease modeling in zebrafish: cancer and immune responses--a report on a workshop held in Spoleto, Italy, July 20-22, 2009
    Marina Mione
    IFOM Foundation FIRC Italian Foundation for Cancer Research Institute of Molecular Oncology, Milan, Italy
    Zebrafish 6:445-51. 2009
    ..The success of this workshop and the rapidly growing field of cancer and the immune response in zebrafish have spawned follow-up meetings in Boston (June 2010) and Edinburgh (2011)...
  15. pmc Expression of H-RASV12 in a zebrafish model of Costello syndrome causes cellular senescence in adult proliferating cells
    Cristina Santoriello
    IFOM, the FIRC Institute for Molecular Oncology Foundation, Milan, Italy
    Dis Model Mech 2:56-67. 2009
    ....
  16. ncbi Pax2.1 is required for the development of thyroid follicles in zebrafish
    Thomas Wendl
    Institute for Developmental Biology, University of Cologne, Gyrhofstrasse 17, D 50923 Köln, Germany
    Development 129:3751-60. 2002
    ..Thus, in zebrafish, some remaining thyroid hormone synthesis takes place independent of the pathway leading to thyroid follicle formation. We suggest that the noi(-/-) mutant serves as a new zebrafish model for hypothyroidism...
  17. doi Neuronal function of Tbx20 conserved from nematodes to vertebrates
    Roger Pocock
    Genetics Unit, Biochemistry Department, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Dev Biol 317:671-85. 2008
    ..We also demonstrate the functional equivalence of human and C. elegans Tbx20 T-box domains for regulating male tail development in the nematode even though these genes play highly diverged roles in organogenesis...
  18. pmc SIRT1 controls endothelial angiogenic functions during vascular growth
    Michael Potente
    Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, 60590 Frankfurt, Germany
    Genes Dev 21:2644-58. 2007
    ..These findings uncover a novel and unexpected role for SIRT1 as a critical modulator of endothelial gene expression governing postnatal vascular growth...
  19. ncbi Differentiation of cerebellar cell identities in absence of Fgf signalling in zebrafish Otx morphants
    Isabelle Foucher
    MRC Centre for Developmental Neurobiology, New Hunt s House, King s College London, London SE1 9RT, UK
    Development 133:1891-900. 2006
    ..This maintenance is enough to allow cerebellar differentiation...
  20. pmc Neurogenin1 is a determinant of zebrafish basal forebrain dopaminergic neurons and is regulated by the conserved zinc finger protein Tof/Fezl
    Jae Yeon Jeong
    Department of Biopharmaceutical Sciences, Program in Human Genetics, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 103:5143-8. 2006
    ..These findings identify Ngn1 as a determinant of brain DA neurons and provide insights into how Tof/Fezl regulates the development of these clinically important neuronal types...
  21. ncbi Zebrafish BarH-like genes define discrete neural domains in the early embryo
    Alicia Colombo
    Anatomy and Developmental Biology Program, Faculty of Medicine, Institute of Biomedical Sciences, Universidad de Chile, Independencia 1027, Santiago, Chile
    Gene Expr Patterns 6:347-52. 2006
    ....
  22. ncbi Early development of functional spatial maps in the zebrafish olfactory bulb
    Jun Li
    Department of Biomedical Optics, Max Planck Institute for Medical Research, 69120 Heidelberg, Germany
    J Neurosci 25:5784-95. 2005
    ....
  23. doi Views on four key questions about zebrafish research
    Keith C Cheng
    Jake Gittlen Cancer Research Foundation, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    Zebrafish 5:9-24. 2008