Research Topics
Genomes and GenesSpecies | Marina C MioneSummaryAffiliation: European Institute of Oncology Country: Italy Publications
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Detail Information
Publications
The zebrafish as a model for cancerMarina C Mione
IFOM Foundation FIRC Institute of Molecular Oncology Foundation, Via Adamello, Milan, Italy
Dis Model Mech 3:517-23. 2010..The overarching goal of the article is aimed at raising the awareness of basic researchers, as well as clinicians, to the versatility of this emerging alternative animal model of cancer...
How neuronal migration contributes to the morphogenesis of the CNS: insights from the zebrafishMarina Mione
IFOM, FIRC Institute of Molecular Oncology, Milan, Italy
Dev Neurosci 30:65-81. 2008..These examples reinforce the concept that migratory events contribute to the distribution of cell types with diverse identities through the CNS and that zebrafish transgenic lines represent excellent tools to study these events...- Expression of pcp4a in subpopulations of CNS neurons in zebrafishMarina Mione
Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
J Comp Neurol 495:769-87. 2006..The analysis of pcp4a expression and localization in the zebrafish brain suggests that pcp4a may be a useful marker for sensory and some motor neuronal circuitries and for telencephalic areas processing sensory inputs... - Conserved and divergent patterns of Reelin expression in the zebrafish central nervous systemArianna Costagli
Department of Anatomy and Developmental Biology, University College London, WC1E 6BT London, United Kingdom
J Comp Neurol 450:73-93. 2002..Thus, the differences in the telencephalic expression of reelin between teleosts and tetrapods are likely to be due to different roles for Reelin during eversion, a process that is specific for the teleost telencephalon... 
How to create the vascular tree? (Latest) help from the zebrafishDanila Baldessari
IFOM IEO Campus FIRC Institute of Molecular Oncology Foundation European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy
Pharmacol Ther 118:206-30. 2008..This information contributes to the prospective of drug discovery to cure human diseases linked to angiogenesis, not last tumours...- Identification of alternatively spliced dab1 isoforms in zebrafishArianna Costagli
Department of Anatomy and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK
Dev Genes Evol 216:291-9. 2006.... - The tumor suppressor PRDM5 regulates Wnt signaling at early stages of zebrafish developmentNatalia Meani
Department on Experimental Oncology, European Institute of Oncology, Milan, Italy
PLoS ONE 4:e4273. 2009..Our data demonstrate that PRDM5 regulates the expression of components of both canonical and non canonical wnt pathways and negatively modulates wnt signaling in vivo... - Stable vascular connections and remodeling require full expression of VE-cadherin in zebrafish embryosMercedes Montero-Balaguer
FIRC Institute of Molecular Oncology, Milan, Italy
PLoS ONE 4:e5772. 2009..However, the mechanism of action of VE-cadherin is complex and, in the mouse embryo, it is difficult to define the specific steps of vascular development in which this protein is involved... - Endocytic trafficking of Rac is required for the spatial restriction of signaling in cell migrationAndrea Palamidessi
IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139 Milan, Italy
Cell 134:135-47. 2008.... - Global repression of cancer gene expression in a zebrafish model of melanoma is linked to epigenetic regulationViviana Anelli
IFOM Foundation FIRC Italian Foundation for Cancer Research Institute of Molecular Oncology, Milan, Italy
Zebrafish 6:417-24. 2009..Although the outcome of these changes is still unknown, they could be responsible for the global repression of gene expression through epigenetic regulation shown in this study... - Monoclonal antibodies isolated by large-scale screening are suitable for labeling adult zebrafish (Danio rerio) tissues and cell structuresGianluca Deflorian
Fondazione IFOM Istituto FIRC di Oncologia Molecolare, Milan, Italy
J Immunol Methods 346:9-17. 2009..Such selection alternative is simpler to organize and could contribute to limit the costs of antibody screening and production... - Disease modeling in zebrafish: cancer and immune responses--a report on a workshop held in Spoleto, Italy, July 20-22, 2009Marina Mione
IFOM Foundation FIRC Italian Foundation for Cancer Research Institute of Molecular Oncology, Milan, Italy
Zebrafish 6:445-51. 2009..The success of this workshop and the rapidly growing field of cancer and the immune response in zebrafish have spawned follow-up meetings in Boston (June 2010) and Edinburgh (2011)... - Expression of H-RASV12 in a zebrafish model of Costello syndrome causes cellular senescence in adult proliferating cellsCristina Santoriello
IFOM, the FIRC Institute for Molecular Oncology Foundation, Milan, Italy
Dis Model Mech 2:56-67. 2009.... - Neuronal function of Tbx20 conserved from nematodes to vertebratesRoger Pocock
Genetics Unit, Biochemistry Department, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
Dev Biol 317:671-85. 2008..We also demonstrate the functional equivalence of human and C. elegans Tbx20 T-box domains for regulating male tail development in the nematode even though these genes play highly diverged roles in organogenesis... - SIRT1 controls endothelial angiogenic functions during vascular growthMichael Potente
Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, 60590 Frankfurt, Germany
Genes Dev 21:2644-58. 2007..These findings uncover a novel and unexpected role for SIRT1 as a critical modulator of endothelial gene expression governing postnatal vascular growth... - Differentiation of cerebellar cell identities in absence of Fgf signalling in zebrafish Otx morphantsIsabelle Foucher
MRC Centre for Developmental Neurobiology, New Hunt s House, King s College London, London SE1 9RT, UK
Development 133:1891-900. 2006..This maintenance is enough to allow cerebellar differentiation... - Neurogenin1 is a determinant of zebrafish basal forebrain dopaminergic neurons and is regulated by the conserved zinc finger protein Tof/FezlJae Yeon Jeong
Department of Biopharmaceutical Sciences, Program in Human Genetics, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 103:5143-8. 2006..These findings identify Ngn1 as a determinant of brain DA neurons and provide insights into how Tof/Fezl regulates the development of these clinically important neuronal types... - Zebrafish BarH-like genes define discrete neural domains in the early embryoAlicia Colombo
Anatomy and Developmental Biology Program, Faculty of Medicine, Institute of Biomedical Sciences, Universidad de Chile, Independencia 1027, Santiago, Chile
Gene Expr Patterns 6:347-52. 2006.... - Pax2.1 is required for the development of thyroid follicles in zebrafishThomas Wendl
Institute for Developmental Biology, University of Cologne, Gyrhofstrasse 17, D 50923 Köln, Germany
Development 129:3751-60. 2002..Thus, in zebrafish, some remaining thyroid hormone synthesis takes place independent of the pathway leading to thyroid follicle formation. We suggest that the noi(-/-) mutant serves as a new zebrafish model for hypothyroidism... - Views on four key questions about zebrafish researchKeith C Cheng
Jake Gittlen Cancer Research Foundation, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
Zebrafish 5:9-24. 2008 - Early development of functional spatial maps in the zebrafish olfactory bulbJun Li
Department of Biomedical Optics, Max-Planck-Institute for Medical Research, 69120 Heidelberg, Germany
J Neurosci 25:5784-95. 2005....