S Minucci

Summary

Affiliation: European Institute of Oncology
Country: Italy

Publications

  1. ncbi request reprint PML-RAR induces promyelocytic leukemias with high efficiency following retroviral gene transfer into purified murine hematopoietic progenitors
    Saverio Minucci
    European Institute of Oncology, Department of Experimental Oncology, Milan, Italy
    Blood 100:2989-95. 2002
  2. ncbi request reprint Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation
    S Minucci
    European Institute of Oncology, Department of Experimental Oncology, Milan, Italy
    Mol Cell 5:811-20. 2000
  3. pmc Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO
    V Gelmetti
    Department of Experimental Oncology, European Institute of Oncology, Milan 20141, Italy
    Mol Cell Biol 18:7185-91. 1998
  4. ncbi request reprint Common themes in the pathogenesis of acute myeloid leukemia
    M Alcalay
    Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy
    Oncogene 20:5680-94. 2001
  5. ncbi request reprint PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
    M Pearson
    European Institute of Oncology, Department of Experimental Oncology, Milan, Italy
    Nature 406:207-10. 2000
  6. ncbi request reprint A redundant oncogenic potential of the retinoic receptor (RAR) alpha, beta and gamma isoforms in acute promyelocytic leukemia
    A Marinelli
    Department of Biomolecular Sciences and Biotechnology, University of Milan, Milan, Italy
    Leukemia 21:647-50. 2007
  7. doi request reprint The self-association coiled-coil domain of PML is sufficient for the oncogenic conversion of the retinoic acid receptor (RAR) alpha
    M Occhionorelli
    Department of Experimental Oncology, IFOM IEO Campus, Milan, Italy
    Leukemia 25:814-20. 2011
  8. ncbi request reprint Histone deacetylases: a common molecular target for differentiation treatment of acute myeloid leukemias?
    S Minucci
    European Institute of Oncology, Department of Experimental Oncology, 20141 Milan, Italy
    Oncogene 20:3110-5. 2001
  9. ncbi request reprint Retinoid receptors in health and disease: co-regulators and the chromatin connection
    S Minucci
    Department of Experimental Oncology, European Institute of Oncology, Milan, 20141, Italy
    Semin Cell Dev Biol 10:215-25. 1999
  10. doi request reprint Blood orange juice inhibits fat accumulation in mice
    L Titta
    Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
    Int J Obes (Lond) 34:578-88. 2010

Collaborators

Detail Information

Publications23

  1. ncbi request reprint PML-RAR induces promyelocytic leukemias with high efficiency following retroviral gene transfer into purified murine hematopoietic progenitors
    Saverio Minucci
    European Institute of Oncology, Department of Experimental Oncology, Milan, Italy
    Blood 100:2989-95. 2002
    ..This model system faithfully reproduces the main characteristics of human APL and represents a versatile tool for the in vitro and in vivo study of mechanisms of leukemogenesis and the design of protocols for differentiation treatment...
  2. ncbi request reprint Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation
    S Minucci
    European Institute of Oncology, Department of Experimental Oncology, Milan, Italy
    Mol Cell 5:811-20. 2000
    ..These results show that oligomerization of a transcription factor, imposing an altered interaction with transcriptional coregulators, represents a novel mechanism of oncogenic activation...
  3. pmc Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO
    V Gelmetti
    Department of Experimental Oncology, European Institute of Oncology, Milan 20141, Italy
    Mol Cell Biol 18:7185-91. 1998
    ....
  4. ncbi request reprint Common themes in the pathogenesis of acute myeloid leukemia
    M Alcalay
    Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy
    Oncogene 20:5680-94. 2001
    ....
  5. ncbi request reprint PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
    M Pearson
    European Institute of Oncology, Department of Experimental Oncology, Milan, Italy
    Nature 406:207-10. 2000
    ..Our data establish a link between PML and p53 and indicate that integrity of the PML bodies is required for p53 acetylation and senescence upon oncogene expression...
  6. ncbi request reprint A redundant oncogenic potential of the retinoic receptor (RAR) alpha, beta and gamma isoforms in acute promyelocytic leukemia
    A Marinelli
    Department of Biomolecular Sciences and Biotechnology, University of Milan, Milan, Italy
    Leukemia 21:647-50. 2007
    ....
  7. doi request reprint The self-association coiled-coil domain of PML is sufficient for the oncogenic conversion of the retinoic acid receptor (RAR) alpha
    M Occhionorelli
    Department of Experimental Oncology, IFOM IEO Campus, Milan, Italy
    Leukemia 25:814-20. 2011
    ..Indeed, in vivo only the CC-RARα chimera induces efficiently APL in a murine transplantation model. Thus, the PML CC domain represents the minimal structural determinant indispensable to transform RARα into an oncogenic protein...
  8. ncbi request reprint Histone deacetylases: a common molecular target for differentiation treatment of acute myeloid leukemias?
    S Minucci
    European Institute of Oncology, Department of Experimental Oncology, 20141 Milan, Italy
    Oncogene 20:3110-5. 2001
    ..Thus, activation of the RA signaling pathway and inhibition of HDAC activity might represent a general strategy for the differentiation treatment of myeloid leukemias...
  9. ncbi request reprint Retinoid receptors in health and disease: co-regulators and the chromatin connection
    S Minucci
    Department of Experimental Oncology, European Institute of Oncology, Milan, 20141, Italy
    Semin Cell Dev Biol 10:215-25. 1999
    ..These results point to a crucial role for control of transcription factor coregulator interactions in the regulation of cellular processes, and suggest new molecular targets for cancer therapy...
  10. doi request reprint Blood orange juice inhibits fat accumulation in mice
    L Titta
    Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
    Int J Obes (Lond) 34:578-88. 2010
    ..To analyze the effect of the juice obtained from two varieties of sweet orange (Citrus sinensis L. Osbeck), Moro (a blood orange) and Navelina (a blond orange), on fat accumulation in mice fed a standard or a high-fat diet (HFD)...
  11. pmc A phase I-II study of the histone deacetylase inhibitor valproic acid plus chemoimmunotherapy in patients with advanced melanoma
    A Rocca
    Department of Medicine, European Institute of Oncology, Via Ripamonti 435, Milan 20141, Italy
    Br J Cancer 100:28-36. 2009
    ....
  12. pmc The tripartite motif family identifies cell compartments
    A Reymond
    Telethon Institute of Genetics and Medicine TIGEM, San Raffaele Biomedical Science Park, Milan, Italy
    EMBO J 20:2140-51. 2001
    ..A total of 37 TRIM genes/proteins were studied, 21 of which were novel. The results demonstrate that TRIM proteins share a common function: by means of homo-multimerization they identify specific cell compartments...
  13. ncbi request reprint Histone deacetylase-targeted treatment restores retinoic acid signaling and differentiation in acute myeloid leukemia
    F F Ferrara
    Department of Histology and Medical Embryology, University of Rome La Sapienza, Italy
    Cancer Res 61:2-7. 2001
    ..These findings relate alteration of the RA pathway to myeloid leukemogenesis and underscore the potential of transcriptional/differentiation therapy in AML...
  14. pmc Oligomerization of ETO is obligatory for corepressor interaction
    J Zhang
    Division of Endocrinology, Diabetes, and Metabolism, Departments of Medicine and Genetics, and The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 21:156-63. 2001
    ..As nuclear receptors also interact with corepressors as dimers, oligomerization may be a common mechanism regulating corepressor interactions...
  15. ncbi request reprint PML4 induces differentiation by Myc destabilization
    M Buschbeck
    Centre de Regulació Genòmica CRG PRBB and Universitat Pompeu Fabra, Barcelona, Spain
    Oncogene 26:3415-22. 2007
    ....
  16. doi request reprint Cortical spreading depression induces the expression of iNOS, HIF-1alpha, and LDH-A
    E Viggiano
    Department of Experimental Medicine, Section of Human Physiology, Second University of Naples, Via Costantinopoli 16, 80138 Napoli, Italy
    Neuroscience 153:182-8. 2008
    ..These data suggest that CSD promotes the expression of iNOS, HIF-1alpha, and LDH-A in nervous cells giving a neuroprotective effect...
  17. ncbi request reprint RAR and RXR selective ligands cooperatively induce apoptosis and neuronal differentiation in P19 embryonal carcinoma cells
    V Horn
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    FASEB J 10:1071-7. 1996
    ..Together, our results indicate that retinoid-induced apoptosis and neuronal differentiation are closely coupled, and that both RAR and RXR play a role in these processes as active receptors for their respective ligands...
  18. ncbi request reprint G1 cell-cycle arrest and apoptosis by histone deacetylase inhibition in MLL-AF9 acute myeloid leukemia cells is p21 dependent and MLL-AF9 independent
    R Tonelli
    Leukemia 20:1307-10. 2006
  19. ncbi request reprint Modulation of pro- and anti-apoptotic factors in human melanoma cells exposed to histone deacetylase inhibitors
    F Facchetti
    Department of Biomolecular Sciences and Biotechnology, University of Milan, 20133 Milan, Italy
    Apoptosis 9:573-82. 2004
    ..In the latter, since activation of caspase 8 was documented, a receptor-mediated apoptosis was suggested. Taken together, our results suggest that HDAC inhibitors may represent a promising therapeutic strategy to treat melanoma...
  20. ncbi request reprint Epigenetic gene silencing in acute promyelocytic leukemia
    R Villa
    Center for Genomic Regulation, Passeig Maritim 37 49, 08003 Barcelona, Spain
    Biochem Pharmacol 68:1247-54. 2004
    ..These observations suggest that epigenetic alterations could actively contribute to the development of APL and other hyperproliferative diseases...
  21. ncbi request reprint Involvement of heparanase in tumor progression and normal differentiation
    I Vlodavsky
    Technion, Haifa, Israel
    Pathophysiol Haemost Thromb 33:59-61. 2003
  22. ncbi request reprint Activation of Rac1 and the p38 mitogen-activated protein kinase pathway in response to all-trans-retinoic acid
    Y Alsayed
    Section of Hematology-Oncology, Department of Medicine, University of Illinois and West Side Veterans Affairs Medical Center, Chicago, Illinois 60607, USA
    J Biol Chem 276:4012-9. 2001
    ..Altogether, our findings demonstrate that the Rac1/p38 MAP kinase pathway is activated in a RA-dependent manner and exhibits negative regulatory effects on the induction of differentiation...
  23. ncbi request reprint Differential 9-cis-retinoic acid-dependent transcriptional activation by murine retinoid X receptor alpha (RXR alpha) and RXR beta. Role of cell type and RXR domains
    P L Hallenbeck
    Genetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 271:10503-7. 1996
    ..These results stress the importance of functional links between different RXR domains and suggest an RXR subtype and cell type-dependent specificity in the control of the 9cRA response...