Research Topics
Genomes and GenesSpecies | P MaisonneuveSummaryAffiliation: European Institute of Oncology Country: Italy Publications
| Collaborators
|
Detail Information
Publications
Impact of smoking on patients with idiopathic chronic pancreatitisPatrick Maisonneuve
Epidemiology Unit, European Institute of Oncology, Milan, Italy
Pancreas 33:163-8. 2006..We studied the impact of smoking on progression of disease as measured by the appearance of calcification and diabetes using Cox regression models...
Cancer risk in cystic fibrosis: a 20-year nationwide study from the United StatesPatrick Maisonneuve
Eng, Division of Epidemiology and Biostatistics, European Institute of Oncology, Via Ripamonti 435, I 20141 Milan, Italy
J Natl Cancer Inst 105:122-9. 2013..Many patients with cystic fibrosis (CF) now reach adulthood, at which time the risk of cancer is increased. The aim of this study was to determine cancer risks in nontransplanted and transplanted CF patients...
Determinants of polyp size in patients undergoing screening colonoscopyAlbert B Lowenfels
Department of Surgery, New York Medical College, Valhalla, USA
BMC Gastroenterol 11:101. 2011..We aim to determine factors associated with polyp size in different age groups...
Cigarette smoking accelerates progression of alcoholic chronic pancreatitisP Maisonneuve
Epidemiology Unit, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
Gut 54:510-4. 2005..Smoking is a recognised risk factor for pancreatic cancer and has been associated with chronic pancreatitis and also with type II diabetes...
Epidemiology of pancreatic cancer: an updatePatrick Maisonneuve
Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy
Dig Dis 28:645-56. 2010..While many risk factors for pancreatic cancer are not modifiable, adopting a healthy lifestyle could substantially reduce pancreatic cancer risk...
Pancreatitis in hispanic patients with cystic fibrosis carrying the R334W mutationPatrick Maisonneuve
Epidemiology Unit, European Institute of Oncology, Milan, Italy
Clin Gastroenterol Hepatol 2:504-9. 2004..The aim of this study is to determine which specific genotypes lead to the development of pancreatitis in patients with CF...
Lung cancer risk prediction to select smokers for screening CT--a model based on the Italian COSMOS trialPatrick Maisonneuve
Division of Epidemiology and Biostatistics, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
Cancer Prev Res (Phila) 4:1778-89. 2011..The Bach model incorporating CT findings at baseline screening could help defining the time interval to subsequent screening in individual participants. Further studies are necessary to validate these models...
Chronic pancreatitis and pancreatic cancerPatrick Maisonneuve
Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy
Dig Dis 20:32-7. 2002..Smoking, which appears to further accelerate the carcinogenic transformation, remains the strongest risk factor amenable to preventive intervention...
Distribution of primary renal diseases leading to end-stage renal failure in the United States, Europe, and Australia/New Zealand: results from an international comparative studyP Maisonneuve
Division of Epidemiology, European Institute of Oncology, Milan, Italy
Am J Kidney Dis 35:157-65. 2000....
Role of endocrine responsiveness and HER2/neu overexpression in inflammatory breast cancer treated with multimodality preoperative therapyClaudia D'Alessandro
Research Unit in Medical Senology, European Institute of Oncology, Milan, Italy
Breast J 14:435-41. 2008..91; 95% CI 1.69-20.7; p = 0.005), in particular if HER2/neu overexpression was detected (HR: 16.5; 95% CI 4.24-64.5; p < 0.0001). New multimodality and targeted strategies should be explored in endocrine nonresponsive breast cancer...
Cancer in patients on dialysis for end-stage renal disease: an international collaborative studyP Maisonneuve
Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy
Lancet 354:93-9. 1999..The aim of this study was to examine the risk of cancer in a large cohort of patients treated by dialysis but not transplantation...
Minimal axillary lymph node involvement in breast cancer has different prognostic implications according to the staging procedureE Montagna
Research Unit in Medical Senology, Department of Medicine, European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy
Breast Cancer Res Treat 118:385-94. 2009..Treatment recommendations for systemic therapy should not take into account the presence of a single micrometastatic lymph node identified during complete serial sectioning of sentinel node(s)...
Role of endocrine responsiveness and adjuvant therapy in very young women (below 35 years) with operable breast cancer and node negative diseaseM Colleoni
Research Unit in Medical Senology, Department of Medicine, Instituto Europeo di Oncologia, Milan, Italy
Ann Oncol 17:1497-503. 2006..There is limited knowledge about prognosis, and treatment effects in young women with node-negative disease...
Cigarette smoking and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (Panc4)C Bosetti
Department of Epidemiology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
Ann Oncol 23:1880-8. 2012..To evaluate the dose-response relationship between cigarette smoking and pancreatic cancer and to examine the effects of temporal variables...
Prognostic role of the extent of peritumoral vascular invasion in operable breast cancerM Colleoni
Research Unit in Medical Senology at the Department of Medicine, Istituto Europeo di Oncologia, Milan, Italy
Ann Oncol 18:1632-40. 2007..4%), focal (368, 14.1%), moderate (51, 2.0%) and extensive (170, 6.5%)...
Histologic detection and clinical implications of micrometastases in axillary sentinel lymph nodes for patients with breast carcinomaG Viale
Division of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
Cancer 92:1378-84. 2001....
Prognosis and adjuvant treatment effects in selected breast cancer subtypes of very young women (<35 years) with operable breast cancerG Cancello
Research Unit in Medical Senology, Department of Medicine, European Institute of Oncology, Milan, Italy
Ann Oncol 21:1974-81. 2010..There is limited knowledge about prognosis of selected breast cancer subtypes among very young women...
Outcome of special types of luminal breast cancerM Colleoni
Department of Medicine, European Institute of Oncology, Milan, Italy
Ann Oncol 23:1428-36. 2012..The identification of special types of breast cancer might be of value in assessing prognosis and predicting response to therapy...
Italian randomized trial among women with hysterectomy: tamoxifen and hormone-dependent breast cancer in high-risk womenUmberto Veronesi
European Institute of Oncology, Milan, Italy
J Natl Cancer Inst 95:160-5. 2003..Such a strategy would greatly reduce the numbers of women who would need to take tamoxifen to obtain the same absolute reduction in breast cancer. These findings are exploratory and need to be confirmed in other randomized trials...
Gestational trophoblastic diseasesH Y Ngan
FIGO Annual Report Editorial Office, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
Int J Gynaecol Obstet 83:167-74. 2003
Carcinoma of the ovaryA P Heintz
FIGO Annual Report Editorial Office, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
Int J Gynaecol Obstet 83:135-66. 2003
Carcinoma of the vaginaU Beller
FIGO Annual Report Editorial Office, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
Int J Gynaecol Obstet 83:27-39. 2003
Carcinoma of the cervix uteriJ L Benedet
FIGO Annual Report Editorial Office, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
Int J Gynaecol Obstet 83:41-78. 2003
Carcinoma of the corpus uteriW T Creasman
FIGO Annual Report Editorial Office, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
Int J Gynaecol Obstet 83:79-118. 2003
Carcinoma of the Fallopian tubeA P Heintz
FIGO Annual Report Editorial Office, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
Int J Gynaecol Obstet 83:119-33. 2003
Nipple sparing mastectomy: can we predict the factors predisposing to necrosis?Z K Algaithy
Division of Plastic Surgery, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
Eur J Surg Oncol 38:125-9. 2012..This study aimed to analyze the factors that may lead to skin necrosis after NSM...
Alcohol consumption and pancreatic cancer: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4)E Lucenteforte
Department of Epidemiology, Istituto di Ricerche Farmacologiche Mario Negri Milan, Milan, Italy
Ann Oncol 23:374-82. 2012..Heavy alcohol drinking has been related to pancreatic cancer, but the issue is still unsolved...
Prognosis in women with small (T1mic,T1a,T1b) node-negative operable breast cancer by immunohistochemically selected subtypesG Cancello
Unit of Research in Medical Senology, Division of Medical Oncology, Department of Medicine, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
Breast Cancer Res Treat 127:713-20. 2011..In conclusion, women with small size, node-negative, breast cancer are at higher risk of relapse if with HER2-positive endocrine receptor absent or Triple Negative disease...
Progesterone receptor loss identifies Luminal B breast cancer subgroups at higher risk of relapseG Cancello
Research Unit in Medical Senology, Department of Medicine, European Institute of Oncology, Milan
Ann Oncol 24:661-8. 2013..Conclusions PgR loss identifies Luminal B breast cancer subgroups at higher risk of relapse and death, both with HER-2-positive and HER-2-negative disease...
Methylenetetrahydrofolate reductase (MTHFR) and breast cancer risk: a nested-case-control study and a pooled meta-analysisDebora Macis
Division of Chemoprevention, European Institute of Oncology, Milan, Italy
Breast Cancer Res Treat 106:263-71. 2007..A reduced activity of methylenetetrahydrofolate reductase (MTHFR) due to frequent C677T polymorphism affects DNA synthesis, repair and methylation and may be implicated in breast cancer risk...
Dual role of RASSF1 as a tumor suppressor and an oncogene in neuroendocrine tumors of the lungGiuseppe Pelosi
Division of Pathology and Laboratory MedicineEuropean Institute of Oncology and National Cancer Institute, Milan, Italy
Anticancer Res 30:4269-81. 2010..Little is known about the dual role of RAS-association domain family 1 (RASSF1) gene at 3p21.3 in neuroendocrine tumors (NET) of the lung...
Immunoreactivity for thyroid transcription factor-1 in stage I non-small cell carcinomas of the lungG Pelosi
Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
Am J Surg Pathol 25:363-72. 2001..Our findings suggest that TTF-1 could be involved in the development of small pulmonary adenocarcinomas, but it has not prognostic implications in patients with stage I NSCLC...
Oral contraceptive use and breast or ovarian cancer risk in BRCA1/2 carriers: a meta-analysisS Iodice
Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy
Eur J Cancer 46:2275-84. 2010..The association between oral contraceptive and BRCA1 or BRCA2 gene mutations carriers is unclear...
Reverse transcription-polymerase chain reaction assay for multiple mRNA markers in the detection of breast cancer metastases in sentinel lymph nodesM Manzotti
Department of Pathology, European Institute of Oncology, Via Ripmaonti 435, I-20141 Milan, Italy
Int J Cancer 95:307-12. 2001..4% and 84.6%, respectively). The high prevalence of positive reverse transcription-polymerase chain reaction assays in histologically uninvolved SLNs, however, may hamper extensive application of these techniques in the clinical setting...
Timing of breast cancer surgery in relation to the menstrual cycle: an update of developmentsS Zurrida
Senology Department, European Institute of Oncology, Milan, Italy
Crit Rev Oncol Hematol 38:223-30. 2001..It is too early to assess the significance of this finding...
Effect of tamoxifen and transdermal hormone replacement therapy on cardiovascular risk factors in a prevention trial. Italian Chemoprevention GroupA Decensi
FIRC Chemoprovention Unit, European Institute of Oncology, Milan, Italy
Br J Cancer 78:572-8. 1998..Whereas a trial of tamoxifen in women already on transdermal HRT is warranted, prescription of HRT during tamoxifen may attenuate its activity...
Predicting mortality risk in patients with compensated HCV-induced cirrhosis: a long-term prospective studySavino Bruno
Department of Internal Medicine, AO Fatebenefratelli e Oftalmico, Milan, Italy
Am J Gastroenterol 104:1147-58. 2009..The identification of prognostic factors associated with mortality is crucial in any clinical setting...
Cancer risk in nontransplanted and transplanted cystic fibrosis patients: a 10-year studyPatrick Maisonneuve
Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy
J Natl Cancer Inst 95:381-7. 2003..This increased risk appeared to be more pronounced in patients who had had an organ transplantation...
Early onset pancreatic cancer: evidence of a major role for smoking and genetic factorsSara Raimondi
Division of Epidemiology and Biostatistics, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
Cancer Epidemiol Biomarkers Prev 16:1894-7. 2007..Smoking and genetic mutations are the major identified risk factors and seem to be even more important for EOPC than for PC in older age groups...
A subset of high-grade pulmonary neuroendocrine carcinomas shows up-regulation of matrix metalloproteinase-7 associated with nuclear beta-catenin immunoreactivity, independent of EGFR and HER-2 gene amplification or expressionGiuseppe Pelosi
Division of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
Virchows Arch 447:969-77. 2005..A minor subset of these tumors shows beta-catenin nuclear accumulation in association with increased expression of MMP-7, but not of cyclin D1, independent of EGFR and HER-2 gene amplification or expression...
Venous thromboembolic events and organ-specific occult cancers: a review and meta-analysisS Iodice
European Institute of Oncology, Milan, Italy
J Thromb Haemost 6:781-8. 2008..Despite a recognized association between venous thromboembolic events (VTE) and cancer, little is known about the strength and the features of this association. We performed a meta-analysis in order to clarify this issue...
Circulating endothelial-cell kinetics and viability predict survival in breast cancer patients receiving metronomic chemotherapyPatrizia Mancuso
Division of Hematology-Oncology, Department of Medicine, European Institute of Oncology, Milan, Italy
Blood 108:452-9. 2006..005). Preclinical models indicated that the source of apoptotic CECs was most likely the tumor vasculature. CEC kinetics and viability are very promising as predictors of clinical response in patients undergoing metronomic chemotherapy...
Avoiding axillary dissection in breast cancer surgery: a randomized trial to assess the role of axillary radiotherapyU Veronesi
Division of Senology, European Institute of Oncology, Via G Ripamonti 435, 20141 Milan, Italy
Ann Oncol 16:383-8. 2005..The aim of the study was to assess the role of axillary radiotherapy (RT) in reducing axillary metastases in patients with early breast cancer who did not receive axillary dissection...
Long-term oncological results of breast conservative treatment with oncoplastic surgeryM Rietjens
Department of Plastic and Reconstructive Surgery, European Institute of Oncology, Milan, Italy
Breast 16:387-95. 2007..53%). Patients with tumours larger than 2 cm were at greater risk of local recurrences and distant metastasis. Long-term oncologic results of BCT with oncoplastic surgery are comparable with the results of BCT randomized trials...
Genomic characterization of asymptomatic CT-detected lung cancersE Belloni
Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
Oncogene 30:1117-26. 2011....
Measuring progress against cancer in Europe: has the 15% decline targeted for 2000 come about?P Boyle
European Institute of Oncology, Milan, Italy
Ann Oncol 14:1312-25. 2003..A programme of activities and research, focussing on three major themes [prevention (particularly tobacco control), screening, and education and training], was developed together with the European Code Against Cancer...
Rationale for a study adding tamoxifen to HRTN Rotmensz
European Institute of Oncology, Milan, Italy
Eur J Cancer 38:S22-3. 2002
Evolution of lung nodules < or =5 mm detected with low-dose CT in asymptomatic smokersM Bellomi
School of Medicine, University of Milano, 7 Via Festa del Perdono, 20122 Milan, Italy
Br J Radiol 80:708-12. 2007..7% did not change, 2.5% grew to > 5 mm and were followed yearly In conclusion, prevalent and incident nodules < or =5 mm detected by low-dose CT screening for lung cancer can be safely checked at 1 year intervals...
Lung cancer screening with low-dose computed tomography: a non-invasive diagnostic protocol for baseline lung nodulesGiulia Veronesi
Department of Thoracic Surgery, European Institute of Oncology, Milan, Italy
Lung Cancer 61:340-9. 2008..We assessed the diagnostic utility of a non-invasive work-up protocol for nodules detected at baseline in volunteers enrolled in our single-centre screening trial, and followed for at least 1 year...
MC1R variants, melanoma and red hair color phenotype: a meta-analysisSara Raimondi
Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy
Int J Cancer 122:2753-60. 2008..These results suggest that MC1R variants could play a role in melanoma development both via pigmentary and non-pigmentary pathways...
Tobacco smoking and cancer: a meta-analysisSara Gandini
Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy
Int J Cancer 122:155-64. 2008..The analysis of heterogeneity showed that study type, gender and adjustment for confounding factors significantly influence the RRs estimates and the reliability of the studies...
Pathologic and molecular features of screening low-dose computed tomography (LDCT)-detected lung cancer: a baseline and 2-year repeat studyGiuseppe Pelosi
Division of Pathology and Laboratory Medicine, European Institute of Oncology, Milan, Italy
Lung Cancer 62:202-14. 2008..Repeat cancers are potentially aggressive tumors. K-ras mutation analysis supports the impression that multifocal tumors at baseline are separate synchronous primaries...
Glycemic index, glycemic load, and cancer risk: a meta-analysisPatrizia Gnagnarella
Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy
Am J Clin Nutr 87:1793-801. 2008..Factors linked to glucose metabolism play an important role in the development of cancers, and both glycemic index (GI) and glycemic load (GL) have been investigated as potential etiologic factors...
Comparative evaluation of an extensive histopathologic examination and a real-time reverse-transcription-polymerase chain reaction assay for mammaglobin and cytokeratin 19 on axillary sentinel lymph nodes of breast carcinoma patientsGiuseppe Viale
Department of Pathology and Laboratory Medicine, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
Ann Surg 247:136-42. 2008....
Nonpalpable breast carcinomas: long-term evaluation of 1,258 casesUmberto Veronesi
IEO European Institute of Oncology, Milan, Italy
Oncologist 15:1248-52. 2010..At present in our institution some 20% of the cases are treated when nonpalpable. The aim of the present study is to analyze the characteristics and prognosis of such tumors treated in a single institution...
Role of positron emission tomography scanning in the management of lung nodules detected at baseline computed tomography screeningGiulia Veronesi
Department of Thoracic Surgery, European Institute of Oncology, Milan, Italy
Ann Thorac Surg 84:959-65; discussion 965-6. 2007..We present results using positron tomography scanning (CT-PET) to evaluate LD-CT-detected lung nodules during the first year of the Continuing Observation of Smoking Subjects (COSMOS) early detection trial for lung cancer...
Cigarette smoking and adenomatous polyps: a meta-analysisEdoardo Botteri
Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy
Gastroenterology 134:388-95. 2008..We performed a meta-analysis to provide a quantitative pooled risk estimate of the association, focusing on the different characteristics of the study populations, study designs, and clinical feature of the polyps...
Prognostic implications of neuroendocrine differentiation and hormone production in patients with Stage I nonsmall cell lung carcinomaGiuseppe Pelosi
Division of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
Cancer 97:2487-97. 2003..However, little is known regarding the prevalence and clinical implications of NE differentiation in patients with Stage I NSCLC...
Sentinel lymph node biopsy in breast cancer: ten-year results of a randomized controlled studyUmberto Veronesi
European Institute of Oncology, Milan, Italy
Ann Surg 251:595-600. 2010..We present 10-year follow-up of our single-institute trial designed to compare outcomes in patients who received no axillary dissection if the sentinel node was negative, with patients who received complete axillary dissection...
Past medical history and pancreatic cancer risk: Results from a multicenter case-control studyPatrick Maisonneuve
European Institute of Oncology, Milan, Italy
Ann Epidemiol 20:92-8. 2010..To investigate risk factors that may be linked to pancreatic cancer...
A critical appraisal of the adjuvant chemotherapy guidelines for patients with completely resected T3N0 non-small-cell lung cancerTommaso De Pas
New Drugs Development and Clinical Pharmacology Unit, Department of Medicine, European Institute of Oncology, Milan, Italy
Acta Oncol 49:480-4. 2010..However, these two tumor subgroups should be considered as different entities. While the efficacy of adjuvant chemotherapy has been established in patients with T1-2N1 NSCLC, its benefit in patients with T3N0 tumor remains questionable...
Four-arm robotic lobectomy for the treatment of early-stage lung cancerGiulia Veronesi
Division of Thoracic Surgery, European Institute of Oncology, Milan, Italy
J Thorac Cardiovasc Surg 140:19-25. 2010..We investigated the feasibility and safety of four-arm robotic lung lobectomy in patients with lung cancer and described the robotic lobectomy technique with mediastinal lymph node dissection...
Epidemiology of pancreatic cancer: an overviewSara Raimondi
Division of Epidemiology and Biostatistics, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
Nat Rev Gastroenterol Hepatol 6:699-708. 2009..Rising prevalence of smoking in developing countries, improved diagnosis and increasing population longevity are all likely to increase the global burden of pancreatic cancer in the coming decades...
Evolution of emphysema in relation to smokingMassimo Bellomi
Department of Radiology, European Institute of Oncology, Via Ripamonti 435, Milan, Italy
Eur Radiol 20:286-92. 2010..The study was approved by our Ethics Committee and all participants provided written informed consent...
Gene-smoking interaction on colorectal adenoma and cancer risk: review and meta-analysisSara Raimondi
Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy
Mutat Res 670:6-14. 2009..None of the other common genetic polymorphisms involved in tobacco carcinogens metabolism seemed to modify the smoking-related risk of colorectal adenoma or cancer...
Pancreatic cancer in chronic pancreatitis; aetiology, incidence, and early detectionSara Raimondi
European Institute of Oncology, Milan, Italy
Best Pract Res Clin Gastroenterol 24:349-58. 2010..Until the development of more sophisticated screening procedures, screening is not recommended for patients with chronic pancreatitis...
Review and meta-analysis on vitamin D receptor polymorphisms and cancer riskSara Raimondi
Division of Epidemiology and Biostatistics, European Institute of Oncology, Via Ripamonti 435, Milan, Italy
Carcinogenesis 30:1170-80. 2009..In conclusion, this meta-analysis showed that VDR FokI and BsmI polymorphisms might modulate the risk of cancer of breast, skin and prostate and possibly affect cancer risk at any site in Caucasians...
Hepatitis C virus genotype 1b as a risk factor for hepatocellular carcinoma development: a meta-analysisSara Raimondi
Division of Epidemiology and Biostatistics, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
J Hepatol 50:1142-54. 2009..We performed a meta-analysis to clarify whether the genotype 1b is associated with a higher risk of HCC than other genotypes...
Smoking and colorectal cancer: a meta-analysisEdoardo Botteri
Division of Epidemiology and Biostatistics, European Institute of Oncology, Via Ripamonti 435, 20141, Milano, Italy
JAMA 300:2765-78. 2008..Colorectal cancer is the third most common form of cancer and the fourth most frequent cause of cancer deaths worldwide. The association between cigarette smoking and colorectal cancer has been inconsistent among studies...
Sentinel-lymph-node biopsy as a staging procedure in breast cancer: update of a randomised controlled studyUmberto Veronesi
Scientific Direction, European Institute of Oncology, Milan, Italy
Lancet Oncol 7:983-90. 2006..Results of our previous trial showed that SLNB accurately screens the ALN for metastasis in breast cancers of diameter 2 mm or less. We aimed to update this trial with results from longer follow-up...
Invasive ductal carcinoma of the breast with the "triple-negative" phenotype: prognostic implications of EGFR immunoreactivityGiuseppe Viale
Division of Pathology, European Institute of Oncology, Milan, Italy
Breast Cancer Res Treat 116:317-28. 2009..EGFR immunoreactivity significantly correlates with worse prognosis in patients with triple-negative IDC, supporting further studies on the correlation between the degree of EGFR expression and outcome of triple negative breast cancer...
Difficulties encountered managing nodules detected during a computed tomography lung cancer screening programGiulia Veronesi
Department of Thoracic Surgery, European Institute of Oncology, Milan, Italy
J Thorac Cardiovasc Surg 136:611-7. 2008..We evaluated the pitfalls, difficulties, and sources of mistakes in the management of lung nodules detected in volunteers in the Cosmos single-center screening trial...
Intraoperative radiotherapy during breast conserving surgery: a study on 1,822 cases treated with electronsUmberto Veronesi
European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
Breast Cancer Res Treat 124:141-51. 2010..4 and 89.7%. ELIOT appears a promising feature in early breast cancer treated with breast conserving surgery, reducing the exposure of normal tissues to radiations and shortening the radiation course from 6 weeks to one single session...
Lack of prognostic significance of "classic" lobular breast carcinoma: a matched, single institution seriesGiuseppe Viale
European Institute of Oncology, University of Milan, Italy
Breast Cancer Res Treat 117:211-4. 2009..Classical lobular histology is not an independent factor in the prognosis of early breast cancer...
Diet diversity and the risk of oral and pharyngeal cancerWerner Garavello
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
Eur J Nutr 47:280-4. 2008..Diet diversity has been recommended to achieve a healthy diet and prevent cancer...
Predicting the status of axillary sentinel lymph nodes in 4351 patients with invasive breast carcinoma treated in a single institutionGiuseppe Viale
Department of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan, Milan, Italy
Cancer 103:492-500. 2005....
A randomized comparison of sentinel-node biopsy with routine axillary dissection in breast cancerUmberto Veronesi
Division of Senology, European Institute of Oncology, Milan, Italy
N Engl J Med 349:546-53. 2003..Although numerous studies have shown that the status of the sentinel node is an accurate predictor of the status of the axillary nodes in breast cancer, the efficacy and safety of sentinel-node biopsy require validation...
Comparison of the Digene HC2 assay and the Roche AMPLICOR human papillomavirus (HPV) test for detection of high-risk HPV genotypes in cervical samplesMaria T Sandri
Laboratory Medicine Unit, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
J Clin Microbiol 44:2141-6. 2006..In conclusion, this study shows that the HC2 assay and the AMPLICOR HPV test give comparable results, with both being suitable for routine use. The differences noted in some cases may suggest a different optimal clinical use...
Radiological features and pathological-biological correlations in 348 women with breast cancer under 35 years oldBrunella Di Nubila
Breast Imaging Unit, European Institute of Oncology, 435, Ripamonti Street, 20141 Milan, Italy
Breast 15:744-53. 2006..Histological and biological profiles may be correlated with imaging sensitivity...
Pleomorphic carcinomas of the lung show a selective distribution of gene products involved in cell differentiation, cell cycle control, tumor growth, and tumor cell motility: a clinicopathologic and immunohistochemical study of 31 casesGiuseppe Pelosi
Department of Pathology and Laboratory Medicine, Institute of European Oncology and University of Milan School of Medicine, Italy
Am J Surg Pathol 27:1203-15. 2003....
Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesisSalvatore Pece
Istituto Europeo di Oncologia, 20141 Milan, Italy
J Cell Biol 167:215-21. 2004..Thus, the Numb/Notch biological antagonism is relevant to the homeostasis of the normal mammary parenchyma and its subversion contributes to human mammary carcinogenesis...
Size of breast cancer metastases in axillary lymph nodes: clinical relevance of minimal lymph node involvementMarco Colleoni
Division of Medical Oncology, Department of Medicine, Istituto Europeo di Oncologia, Via Ripamonti 435, 20141, Milan, Italy
J Clin Oncol 23:1379-89. 2005....
Alteration of the E-cadherin/beta-catenin cell adhesion system is common in pulmonary neuroendocrine tumors and is an independent predictor of lymph node metastasis in atypical carcinoidsGiuseppe Pelosi
Division of Pathology and Laboratory Medicine, European Institute of Oncology, University of Milan School of Medicine, Milan, Italy
Cancer 103:1154-64. 2005..To the authors' knowledge, little is known regarding the role of E-cadherin/beta-catenin system dysregulation in pulmonary neuroendocrine tumors...
Effect of tamoxifen on venous thromboembolic events in a breast cancer prevention trialAndrea Decensi
Divisions of Chemoprevention, European Institute of Oncology, Milan, Italy
Circulation 111:650-6. 2005..Atherosclerosis may induce VTE, or the 2 conditions may share common risk factors. We assessed the effect of tamoxifen on VTE in a breast cancer prevention trial and studied its association with risk factors for VTE...
Cyclin D3 immunoreactivity is an independent predictor of survival in laryngeal squamous cell carcinomaGiancarlo Pruneri
Division of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
Clin Cancer Res 11:242-8. 2005..To analyze the prevalence and clinical relevance of cyclin D3 abnormalities in laryngeal squamous cell carcinoma (LSCC)...
Vitamin D and skin cancer: a meta-analysisSara Gandini
Division of Epidemiology and Biostatistics, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
Eur J Cancer 45:634-41. 2009..The association with Vitamin D intake is less clear and further studies could be useful to clarify the role of diet...
Predicting the risk for additional axillary metastases in patients with breast carcinoma and positive sentinel lymph node biopsyGiuseppe Viale
Department of Pathology and Laboratory Medicine, European Institute of Oncology, University of Milan School of Medicine, Milan, Italy
Ann Surg 241:319-25. 2005..To assess whether the risk for nonsentinel node metastases may be predicted, thus sparing a subgroup of patients with breast carcinoma and a positive sentinel lymph node (SLN) biopsy completion axillary lymph node dissection (ALND)...
Lack of prognostic implications of HER-2/neu abnormalities in 345 stage I non-small cell carcinomas (NSCLC) and 207 stage I-III neuroendocrine tumours (NET) of the lungGiuseppe Pelosi
Division of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
Int J Cancer 113:101-8. 2005..Among neuroendocrine tumours, LCNEC show a slightly higher prevalence of either HER-2/neu gene amplification or protein overexpression...
Metaplastic carcinoma of the breast, an unusual disease with worse prognosis: the experience of the European Institute of Oncology and review of the literatureAlberto Luini
Division of Breast Surgery, European Institute of Oncology, Milan, Italy
Breast Cancer Res Treat 101:349-53. 2007..The purpose of the present study was to compare the clinical course, and prognosis, between this type of tumor and poorly differentiated ductal carcinoma...
Independent value of fascin immunoreactivity for predicting lymph node metastases in typical and atypical pulmonary carcinoidsGiuseppe Pelosi
Department of Pathology and Laboratory Medicine, European Institute of Oncology, University of Milan School of Medicine, Via G Ripamonti, 435, I 20141 Milan, Italy
Lung Cancer 42:203-13. 2003..Targeting the fascin pathway could be a novel therapeutic strategy of pulmonary carcinoids...
Tamoxifen for the prevention of breast cancer: late results of the Italian Randomized Tamoxifen Prevention Trial among women with hysterectomyUmberto Veronesi
Scientific Directorate, European Institute of Oncology, Milan, Italy
J Natl Cancer Inst 99:727-37. 2007..Here we present an extended follow-up of the Italian trial...
p63 immunoreactivity in lung cancer: yet another player in the development of squamous cell carcinomas?Giuseppe Pelosi
Department of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
J Pathol 198:100-9. 2002..Although p63 is likely to be involved in the development of pulmonary squamous cell carcinoma, it does not carry any prognostic implication for NSCLC patients...
Serum EGFR and serum HER-2/neu are useful predictive and prognostic markers in metastatic breast cancer patients treated with metronomic chemotherapyMaria Teresa Sandri
Unit of Laboratory Medicine, European Institute of Oncology, Milan, Italy
Cancer 110:509-17. 2007..The aim of the study was to evaluate the prognostic and predictive role of serum HER-2/neu and serum EGFR in breast cancer patients treated with low-dose chemotherapy...
A randomized phase II trial comparing preoperative plus perioperative chemotherapy with preoperative chemotherapy in patients with locally advanced breast cancerAndrea Rocca
Unit of Research in Medical Senology, Department of Medicine, Division of Pathology, University of Milan School of Medicine, Italy
Anticancer Drugs 17:1201-9. 2006..Perioperative chemotherapy failed to show an increase in the pathological complete remission rate. A biological effect on Ki-67 expression was demonstrated...
K-ras gene mutational analysis supports a monoclonal origin of biphasic pleomorphic carcinoma of the lungGiuseppe Pelosi
Department of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
Mod Pathol 17:538-46. 2004....
3q26 Amplification and polysomy of chromosome 3 in squamous cell lesions of the lung: a fluorescence in situ hybridization studyGiuseppe Pelosi
Division of Pathology and Laboratory Medicine, European Institute of Oncology, University of Milan School of Medicine and Cancer Genetic Unit, IFOM Foundation FIRC Institute of Molecular Oncology Foundation, Milan, Italy
Clin Cancer Res 13:1995-2004. 2007....
Metronomic low-dose oral cyclophosphamide and methotrexate plus or minus thalidomide in metastatic breast cancer: antitumor activity and biological effectsM Colleoni
Division of Medical Oncology, University of Milan School of Medicine, European Institute of Oncology, Milan, Italy
Ann Oncol 17:232-8. 2006..We previously demonstrated efficacy and impact on serum vascular endothelial growth factor (VEGF) for metronomic cyclophosphamide (C) and methotrexate (M) in patients with breast cancer. New metronomic schedules were investigated...
Cancer control in women. Update 2003P Boyle
Dept of Epidemiology and Biostatistics, European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy
Int J Gynaecol Obstet 83:179-202. 2003..Although more work is needed, it is becoming clear that there could be an important role of HPV testing to further enhance cervix cancer screening...
Is colonoscopy a suitable investigation in the preoperative staging of ovarian cancer patients?D Ravizza
European Institute of Oncology, Via Ripamonti 435, Milan 20141, Italy
Dig Liver Dis 37:57-61. 2005..During ovarian cancer surgery, colorectal resection may be required. In our institution, preoperative colonoscopy is performed in order to assess visceral involvement...
Tobacco and the risk of pancreatic cancer: a review and meta-analysisSimona Iodice
Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy
Langenbecks Arch Surg 393:535-45. 2008....
European Code Against Cancer and scientific justification: third version (2003)P Boyle
Department of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy
Ann Oncol 14:973-1005. 2003
