Alberto Luini

Summary

Affiliation: European Institute of Oncology
Country: Italy

Publications

  1. ncbi request reprint Development of axillary surgery in breast cancer
    A Luini
    Division of Breast Surgery, European Institute of Oncology, Via G Ripamonti 435, 20141 Milan, Italy
    Ann Oncol 16:259-62. 2005
  2. ncbi request reprint Angiosarcoma of the breast: the experience of the European Institute of Oncology and a review of the literature
    Alberto Luini
    Division of Breast Surgery, European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy
    Breast Cancer Res Treat 105:81-5. 2007
  3. ncbi request reprint Metaplastic carcinoma of the breast, an unusual disease with worse prognosis: the experience of the European Institute of Oncology and review of the literature
    Alberto Luini
    Division of Breast Surgery, European Institute of Oncology, Milan, Italy
    Breast Cancer Res Treat 101:349-53. 2007
  4. ncbi request reprint Male breast cancer in a young patient treated with nipple-sparing mastectomy: case report and review of the literature
    Alberto Luini
    Division of Breast Surgery, European Institute of Oncology, Milan, Italy
    Tumori 93:118-20. 2007
  5. doi request reprint The surgical margin status after breast-conserving surgery: discussion of an open issue
    Alberto Luini
    Senology Division, European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy
    Breast Cancer Res Treat 113:397-402. 2009
  6. ncbi request reprint Sentinel lymph node biopsy performed with local anesthesia in patients with early-stage breast carcinoma
    Alberto Luini
    Senology Division, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Arch Surg 137:1157-60. 2002
  7. ncbi request reprint Conservative treatment of breast cancer: its evolution
    Alberto Luini
    Division of Breast Surgery, European Institute of Oncology, Milan, Italy
    Breast Cancer Res Treat 94:195-8. 2005
  8. ncbi request reprint The pilot trial on intraoperative radiotherapy with electrons (ELIOT): update on the results
    Alberto Luini
    Division of Breast Surgery, University of Milan, Milan, Italy
    Breast Cancer Res Treat 93:55-9. 2005
  9. ncbi request reprint The evolution of the conservative approach to breast cancer
    Alberto Luini
    Division of Breast Surgery, European Institute of Oncology, Via Ripamonti 435, Milan, Italy
    Breast 16:120-9. 2007
  10. ncbi request reprint The sentinel node biopsy after previous breast surgery: preliminary results on 543 patients treated at the European Institute of Oncology
    Alberto Luini
    Division of Breast Surgery, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Breast Cancer Res Treat 89:159-63. 2005

Detail Information

Publications154 found, 100 shown here

  1. ncbi request reprint Development of axillary surgery in breast cancer
    A Luini
    Division of Breast Surgery, European Institute of Oncology, Via G Ripamonti 435, 20141 Milan, Italy
    Ann Oncol 16:259-62. 2005
    ..We discuss the evolution of axillary surgery in breast cancer...
  2. ncbi request reprint Angiosarcoma of the breast: the experience of the European Institute of Oncology and a review of the literature
    Alberto Luini
    Division of Breast Surgery, European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy
    Breast Cancer Res Treat 105:81-5. 2007
    ..We report the experience of the European Institute of Oncology with this unusual disease from January 1996 to January 2006: sixteen patients with angiosarcoma, 9 (56%) of whom had primary AB and 7 (44%), secondary AB, are discussed...
  3. ncbi request reprint Metaplastic carcinoma of the breast, an unusual disease with worse prognosis: the experience of the European Institute of Oncology and review of the literature
    Alberto Luini
    Division of Breast Surgery, European Institute of Oncology, Milan, Italy
    Breast Cancer Res Treat 101:349-53. 2007
    ..The purpose of the present study was to compare the clinical course, and prognosis, between this type of tumor and poorly differentiated ductal carcinoma...
  4. ncbi request reprint Male breast cancer in a young patient treated with nipple-sparing mastectomy: case report and review of the literature
    Alberto Luini
    Division of Breast Surgery, European Institute of Oncology, Milan, Italy
    Tumori 93:118-20. 2007
    ..We here describe a case of male breast carcinoma in a young patient (44 years of age), which is quite unusual in the pattern of breast carcinoma presentation...
  5. doi request reprint The surgical margin status after breast-conserving surgery: discussion of an open issue
    Alberto Luini
    Senology Division, European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy
    Breast Cancer Res Treat 113:397-402. 2009
    ..Radiation therapy could be a good option in the management of these cases, but further evidence is needed to establish the real impact of clear surgical margins on local control of disease and, furthermore, on survival...
  6. ncbi request reprint Sentinel lymph node biopsy performed with local anesthesia in patients with early-stage breast carcinoma
    Alberto Luini
    Senology Division, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Arch Surg 137:1157-60. 2002
    ..This method represents an interesting development in breast-conserving surgery...
  7. ncbi request reprint Conservative treatment of breast cancer: its evolution
    Alberto Luini
    Division of Breast Surgery, European Institute of Oncology, Milan, Italy
    Breast Cancer Res Treat 94:195-8. 2005
    ..From an oncological perspective, outcome was found to be equally effective, and this key observation provided us with significant impetus to investigate the effects of reducing the radiotherapy field...
  8. ncbi request reprint The pilot trial on intraoperative radiotherapy with electrons (ELIOT): update on the results
    Alberto Luini
    Division of Breast Surgery, University of Milan, Milan, Italy
    Breast Cancer Res Treat 93:55-9. 2005
    ..At the European Institute of Oncology we started our study on ELIOT in 1999; the first step has been a phase I-II trial to test feasibility and tolerance of ELIOT in patients candidate to breast conserving surgery...
  9. ncbi request reprint The evolution of the conservative approach to breast cancer
    Alberto Luini
    Division of Breast Surgery, European Institute of Oncology, Via Ripamonti 435, Milan, Italy
    Breast 16:120-9. 2007
    ..For this reason in our Institute we are now evaluating the feasibility of a reduction of the radiation field and the sensibility and sensitivity of new diagnostic approaches for axillary staging...
  10. ncbi request reprint The sentinel node biopsy after previous breast surgery: preliminary results on 543 patients treated at the European Institute of Oncology
    Alberto Luini
    Division of Breast Surgery, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Breast Cancer Res Treat 89:159-63. 2005
    ..A previous breast biopsy has been considered a relative contraindication to SLNB. We examined the accuracy of SLNB by following the axillary relapses after the procedure in patients who had undergone a breast biopsy before SLNB...
  11. ncbi request reprint Occult breast lesion localization plus sentinel node biopsy (SNOLL): experience with 959 patients at the European Institute of Oncology
    Simonetta Monti
    Division of Senology, European Institute of Oncology, Via Ripamonti 435, 20141 Milano, Italy
    Ann Surg Oncol 14:2928-31. 2007
    ..We report our experience using radio-guided occult lesion localization (ROLL) for locating and removing non-palpable breast lesions together with sentinel node biopsy (SNB) to assess axillary status. We call the technique SNOLL...
  12. ncbi request reprint Sentinel-lymph-node biopsy as a staging procedure in breast cancer: update of a randomised controlled study
    Umberto Veronesi
    Scientific Direction, European Institute of Oncology, Milan, Italy
    Lancet Oncol 7:983-90. 2006
    ..Results of our previous trial showed that SLNB accurately screens the ALN for metastasis in breast cancers of diameter 2 mm or less. We aimed to update this trial with results from longer follow-up...
  13. doi request reprint Neoadjuvant pegylated liposomal doxorubicin in combination with cisplatin and infusional fluoruracil (CCF) with and without endocrine therapy in locally advanced primary or recurrent breast cancer
    Rosalba Torrisi
    Research Unit of Medical Senology, European Institute of Oncology, Via Ripamonti 435, Milan, Italy
    Breast 20:34-8. 2011
    ..To explore the activity of pegylated liposomal doxorubicin (PLD) as neoadjuvant therapy of breast cancer...
  14. doi request reprint Invasive ductal carcinoma of the breast with the "triple-negative" phenotype: prognostic implications of EGFR immunoreactivity
    Giuseppe Viale
    Division of Pathology, European Institute of Oncology, Milan, Italy
    Breast Cancer Res Treat 116:317-28. 2009
    ..EGFR immunoreactivity significantly correlates with worse prognosis in patients with triple-negative IDC, supporting further studies on the correlation between the degree of EGFR expression and outcome of triple negative breast cancer...
  15. doi request reprint Axillary metastases in breast cancer patients with negative sentinel nodes: a follow-up of 3548 cases
    Umberto Veronesi
    Scientific Director European Institute of Oncology, Via G Ripamonti 435, I 20141 Milan, Italy
    Eur J Cancer 45:1381-8. 2009
    ..PREMISES: Sentinel node biopsy (SNB) in patients with breast carcinoma accurately predicts the axillary node status. However, in some 4-7% of patients with negative sentinel nodes, the remaining axillary nodes harbour cancer cells...
  16. doi request reprint Pathological complete response after preoperative systemic therapy and outcome: relevance of clinical and biologic baseline features
    Emilia Montagna
    Division of Medical Oncology, Department of Medicine, European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy
    Breast Cancer Res Treat 124:689-99. 2010
    ..A substantial rate of relapse was observed for patients with large tumors and with clinical nodal involvement at baseline. Further improvement in adjuvant treatment might be warranted...
  17. pmc Full-dose intraoperative radiotherapy with electrons during breast-conserving surgery: experience with 590 cases
    Umberto Veronesi
    Istituto Europeo di Oncologia, Division of Radiotherapy, Istituto Europeo di Oncologia, Milan, Italy
    Ann Surg 242:101-6. 2005
    ..The new mobile linear accelerators easily moved close to the operating table to allow the full-dose irradiation during surgery...
  18. doi request reprint Positive axillary sentinel lymph node: is axillary dissection always necessary?
    Viviana Galimberti
    Division ofSenology, European Institute of Oncology, Milan, Italy
    Breast 20:S96-8. 2011
    ..Ancillary analyses of the IBCSG 23-01 and AMAROS trials, still in follow-up, may be able to do this...
  19. doi request reprint Local therapy for breast cancer in malignant lymphoma survivors
    Mattia Intra
    Division of Breast Surgery, European Institute of Oncology, Milan, Italy
    Breast 20:S99-103. 2011
    ..We performed a retrospective review to assess the potential of performing breast conservative surgery and intraoperative radiotherapy with electrons (ELIOT), in these patients...
  20. ncbi request reprint A randomized comparison of sentinel-node biopsy with routine axillary dissection in breast cancer
    Umberto Veronesi
    Division of Senology, European Institute of Oncology, Milan, Italy
    N Engl J Med 349:546-53. 2003
    ..Although numerous studies have shown that the status of the sentinel node is an accurate predictor of the status of the axillary nodes in breast cancer, the efficacy and safety of sentinel-node biopsy require validation...
  21. ncbi request reprint Intraoperative avidination for radionuclide therapy: a prospective new development to accelerate radiotherapy in breast cancer
    Giovanni Paganelli
    Division of Nuclear Medicine, European Institute of Oncology, Milan, Italy
    Clin Cancer Res 13:5646s-5651s. 2007
    ..In a continuous effort to seek for anticancer treatments with minimal side effects, we aim at proving the feasibility of the Intraoperative Avidination for Radionuclide Therapy, a new procedure for partial breast irradiation...
  22. ncbi request reprint Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): a randomised controlled equivalence trial
    Umberto Veronesi
    Scientific Directorate, European Institute of Oncology, Milan, Italy Electronic address
    Lancet Oncol 14:1269-77. 2013
    ..However, its ability to control for recurrence of local disease required confirmation in a randomised controlled trial...
  23. ncbi request reprint Sentinel lymph node biopsy is feasible even after total mastectomy
    Mattia Intra
    Division of Breast Surgery, European Institute of Oncology, Milan, Italy
    J Surg Oncol 95:175-9. 2007
    ..Previous mastectomy is unanimously considered to represent an absolute technical contraindication to sentinel lymph node biopsy (SLNB)...
  24. ncbi request reprint Ipsilateral breast tumor reappearance in patients treated with conservative surgery after primary chemotherapy. The role of surgical margins on outcome
    Oreste Gentilini
    Division of Breast Surgery, European Institute of Oncology, Milan, Italy
    J Surg Oncol 94:375-9. 2006
    ..To evaluate the ipsilateral breast tumor reappearance (IBTR) rate after breast conservative surgery (BCS) following primary chemotherapy (PC) and to assess whether positive margins affects IBTR rate and overall survival (OS)...
  25. doi request reprint Repeating conservative surgery after ipsilateral breast tumor reappearance: criteria for selecting the best candidates
    Oreste Gentilini
    Division of Breast Surgery, European Institute of Oncology, Milan, Italy
    Ann Surg Oncol 19:3771-6. 2012
    ..Mastectomy is still considered the treatment of first choice in patients with ipsilateral breast tumor recurrence (IBTR) after breast-conserving surgery (BCS) and whole-breast radiotherapy...
  26. ncbi request reprint Can we avoid axillary dissection in the micrometastatic sentinel node in breast cancer?
    Viviana Galimberti
    Division of Senology, Unit of Molecular Senology, European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy
    Breast Cancer Res Treat 131:819-25. 2012
    ..Nevertheless, a subset of patients might be at high risk of developing overt axillary disease and efforts should be made to identify such patients by ancillary analyses of the results of ongoing or recently published clinical trials...
  27. ncbi request reprint Nipple-sparing mastectomy in association with intra operative radiotherapy (ELIOT): A new type of mastectomy for breast cancer treatment
    Jean Yves Petit
    Division of Plastic Surgery, European Institute of Oncology, Milan, Italy
    Breast Cancer Res Treat 96:47-51. 2006
    ..In fact, although removal of the NAC greatly increases the patient's sensation of mutilation, and the risk of tumor involvement of the areola is reported as a very variable percentage, NAC excision still remains the standard treatment...
  28. doi request reprint Randomized biomarker trial of anastrozole or low-dose tamoxifen or their combination in subjects with breast intraepithelial neoplasia
    Bernardo Bonanni
    Divisions of Cancer Prevention and Genetics, European Institute of Oncology, Milan, University of Milan School of Medicine, Milan, Italy
    Clin Cancer Res 15:7053-60. 2009
    ..The influence of CYP2D6 genotype on tamoxifen effects was also determined...
  29. ncbi request reprint Tailored preoperative treatment of locally advanced triple negative (hormone receptor negative and HER2 negative) breast cancer with epirubicin, cisplatin, and infusional fluorouracil followed by weekly paclitaxel
    Rosalba Torrisi
    Research Unit of Medical Senology, European Institute of Oncology, Via Ripamonti, 435 20141, Milan, Italy
    Cancer Chemother Pharmacol 62:667-72. 2008
    ..No specific treatment guidelines are available for triple-negative breast cancers, defined by a lack of expression of estrogen (ER), progesterone (PgR), and HER2 receptors...
  30. doi request reprint Pegylated liposomal doxorubicin in combination with low-dose metronomic cyclophosphamide as preoperative treatment for patients with locally advanced breast cancer
    Silvia Dellapasqua
    Medical Senology Research Unit, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Breast 20:319-23. 2011
    ..To evaluate the role of pegylated liposomal doxorubicin with low-dose metronomic cyclophosphamide as primary systemic treatment in locally advanced breast cancer...
  31. ncbi request reprint Sentinel node biopsy in breast cancer: early results in 953 patients with negative sentinel node biopsy and no axillary dissection
    Umberto Veronesi
    European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Eur J Cancer 41:231-7. 2005
    ..The 5 year overall survival rate of the whole series was 98%. Patients with negative sentinel node biopsies not submitted to axillary dissection show during follow-up a rate of overt axillary metastases that is lower than that expected...
  32. ncbi request reprint Can axillary and supraclavicular radiotherapy be avoided after breast-conserving surgery and axillary dissection in women with multiple involved axillary nodes? Experience at the European Institute of Oncology
    Viviana Galimberti
    Department of Senology, European Institute of Oncology, Milan, Italy
    Tumori 94:52-8. 2008
    ..We performed a retrospective analysis of patients with 4 or more axillary nodes involved and sufficient follow-up to provide indications as to whether our current treatment is adequate...
  33. doi request reprint Intraoperative radiotherapy during breast conserving surgery: a study on 1,822 cases treated with electrons
    Umberto Veronesi
    European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Breast Cancer Res Treat 124:141-51. 2010
    ..4 and 89.7%. ELIOT appears a promising feature in early breast cancer treated with breast conserving surgery, reducing the exposure of normal tissues to radiations and shortening the radiation course from 6 weeks to one single session...
  34. doi request reprint Heterogeneity of triple-negative breast cancer: histologic subtyping to inform the outcome
    Emilia Montagna
    Research Unit in Medical Senology, Department of Medicine, European Institute of Oncology, Milan, Italy
    Clin Breast Cancer 13:31-9. 2013
    ..This study assesses outcome in terms of disease-free survival (DFS) and overall survival (OS) of special types of triple-negative breast cancer (TNBC)...
  35. ncbi request reprint Phase II trial of combination of pegylated liposomal doxorubicin, cisplatin, and infusional 5-fluorouracil (CCF) plus trastuzumab as preoperative treatment for locally advanced and inflammatory breast cancer
    Rosalba Torrisi
    Research Unit of Medical Senology, European Institute of Oncology, Milan, Italy
    Clin Breast Cancer 10:483-8. 2010
    ..Given its low cardiotoxicity, the combination of PLD and trastuzumab appears most attractive in the treatment of human epidermal factor receptor 2 (HER2)-positive breast cancer...
  36. doi request reprint Sentinel lymph node biopsy in breast cancer: ten-year results of a randomized controlled study
    Umberto Veronesi
    European Institute of Oncology, Milan, Italy
    Ann Surg 251:595-600. 2010
    ..We present 10-year follow-up of our single-institute trial designed to compare outcomes in patients who received no axillary dissection if the sentinel node was negative, with patients who received complete axillary dissection...
  37. pmc Nonpalpable breast carcinomas: long-term evaluation of 1,258 cases
    Umberto Veronesi
    IEO European Institute of Oncology, Milan, Italy
    Oncologist 15:1248-52. 2010
    ..At present in our institution some 20% of the cases are treated when nonpalpable. The aim of the present study is to analyze the characteristics and prognosis of such tumors treated in a single institution...
  38. doi request reprint Breast-conserving surgery in BRCA1/2 mutation carriers: are we approaching an answer?
    Carlos A Garcia-Etienne
    Breast Surgery Department, European Institute of Oncology, Milan, Italy
    Ann Surg Oncol 16:3380-7. 2009
    ..The optimal local therapy for women with BRCA-associated breast carcinoma remains controversial. We report the outcome of BCS in BRCA mutation carriers followed at a single institution...
  39. doi request reprint Preliminary results of electron intraoperative therapy boost and hypofractionated external beam radiotherapy after breast-conserving surgery in premenopausal women
    Giovanni Battista Ivaldi
    Department of Radiation Oncology, European Institute of Oncology, Milan, Italy
    Int J Radiat Oncol Biol Phys 72:485-93. 2008
    ..To report the acute and preliminary data on late toxicity of a pilot study of boost with electron intraoperative therapy followed by hypofractionated external beam radiotherapy (HEBRT) of the whole breast...
  40. ncbi request reprint Real-time in vivo dosimetry using micro-MOSFET detectors during intraoperative electron beam radiation therapy in early-stage breast cancer
    Mario Ciocca
    Department of Medical Physics, European Institute of Oncology, Milano, Italy
    Radiother Oncol 78:213-6. 2006
    ..In the present study, a further step was made, aiming at the improvement of the effectiveness of in vivo dosimetry, based on a real-time check of the dose...
  41. ncbi request reprint Second biopsy of axillary sentinel lymph node for reappearing breast cancer after previous sentinel lymph node biopsy
    Mattia Intra
    Division of Breast Surgery, European Institute of Oncology, Via Ripamonti, 435, 20141, Milan, Italy
    Ann Surg Oncol 12:895-9. 2005
    ..Although a previous SLNB is often considered a contraindication for a subsequent SLNB, few data support this concern...
  42. doi request reprint Metronomic chemotherapy combined with bevacizumab and erlotinib in patients with metastatic HER2-negative breast cancer: clinical and biological activity
    Emilia Montagna
    Department of Medicine, European Institute of Oncology, Milan, Italy
    Clin Breast Cancer 12:207-14. 2012
    ..The analysis of the results suggests that the metronomic chemotherapy combined with bevacizumab and erlotinib is effective and well tolerated...
  43. doi request reprint Increased mean corpuscular volume of red blood cells predicts response to metronomic capecitabine and cyclophosphamide in combination with bevacizumab
    Silvia Dellapasqua
    Medical Senology Research Unit, Department of Medicine, European Institute of Oncology, Milan, Italy
    Breast 21:309-13. 2012
    ..There is an urgent need for the identification of commonly assessable predictive factors in the treatment of patients with metastatic breast cancer...
  44. doi request reprint Immunohistochemically defined subtypes and outcome in occult breast carcinoma with axillary presentation
    Emilia Montagna
    Division of Medical Oncology, Department of Medicine, Unit Research of Medical Senology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Breast Cancer Res Treat 129:867-75. 2011
    ..The outcome of OBC patients is comparable with that of matched patients with small sized breast cancer. High risk of relapse and death was observed in OBC patients with triple negative tumours and extensive nodal involvement...
  45. doi request reprint Increasing steroid hormone receptors expression defines breast cancer subtypes non responsive to preoperative chemotherapy
    Marco Colleoni
    Department of Medicine, Research Unit in Medical Senology, European Institute of Oncology, Milan, Italy
    Breast Cancer Res Treat 116:359-69. 2009
    ..4, 95% CI 3.5-11.6, for DFS; HR 3.6 95% CI 2.4-5.6 for OS). Response and outcome after PCT are correlated with the degree of expression of steroid hormone receptors. Studies on tailored preoperative therapies are needed...
  46. doi request reprint Letrozole plus GnRH analogue as preoperative and adjuvant therapy in premenopausal women with ER positive locally advanced breast cancer
    Rosalba Torrisi
    Research Unit of Medical Senology at the Department of Medicine, European Institute of Oncology, Milano, Italy
    Breast Cancer Res Treat 126:431-41. 2011
    ....
  47. ncbi request reprint Unnecessary axillary node dissections in the sentinel lymph node era
    Mattia Intra
    Division of Breast Surgery, European Institute of Oncology, Via Ripamonti, 435, 20141 Milan, Italy
    Eur J Cancer 43:2664-8. 2007
    ..As the clinical indications to SNB are progressively extending to encompass most breast cancer patients with non-metastatic disease who were previously excluded, great effort should be made to avoid 'unnecessary ALNDs'...
  48. ncbi request reprint Size of breast cancer metastases in axillary lymph nodes: clinical relevance of minimal lymph node involvement
    Marco Colleoni
    Division of Medical Oncology, Department of Medicine, Istituto Europeo di Oncologia, Via Ripamonti 435, 20141, Milan, Italy
    J Clin Oncol 23:1379-89. 2005
    ....
  49. doi request reprint Breast-conserving surgery in 201 very young patients (<35 years)
    Oreste Gentilini
    Division of Breast Surgery, European Institute of Oncology, Via Ripamonti 435, Milan, Italy
    Breast 19:55-8. 2010
    ..Surgical treatment of breast cancer in very young patients (<35 years) is still a matter of debate, since age is a predictive factor of local recurrence after breast conservation...
  50. ncbi request reprint The sentinel node biopsy under local anesthesia in breast cancer: advantages and problems, how the technique influenced the activity of a breast surgery department; update from the European Institute of Oncology with more than 1000 cases
    Alberto Luini
    Division of Breast Surgery, European Institute of Oncology, Milan, Italy
    Breast 16:527-32. 2007
    ..We are now discussing the impact of the SLNB under local anesthesia on the activity of a breast surgery department. We also present an update of our experience...
  51. doi request reprint Immunohistochemically defined subtypes and outcome of apocrine breast cancer
    Silvia Dellapasqua
    Research Unit in Medical Senology, Department of Medicine, European Institute of Oncology, Milan, Italy
    Clin Breast Cancer 13:95-102. 2013
    ..Conflicting data are available in the literature on the outcome of invasive apocrine carcinoma (IAC), possibly related to a heterogeneous classification of these tumors...
  52. pmc Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23-01): a phase 3 randomised controlled trial
    Viviana Galimberti
    Molecular Senology Unit, Senology Division, European Institute of Oncology, Milan, Italy
    Lancet Oncol 14:297-305. 2013
    ..We designed IBCSG trial 23-01 to determine whether no axillary dissection was non-inferior to axillary dissection in patients with one or more micrometastatic (≤2 mm) sentinel nodes and tumour of maximum 5 cm...
  53. ncbi request reprint Predictors of invasive breast cancer and lymph node involvement in ductal carcinoma in situ initially diagnosed by vacuum-assisted breast biopsy: experience of 733 cases
    Chiara Trentin
    Division of Breast Radiology, European Institute of Oncology, Via Ripamonti 435, Milan, Italy
    Breast 21:635-40. 2012
    ..To predict presence of invasive component and nodal involvement in women diagnosed preoperatively with ductal carcinoma in situ (DCIS) by vacuum-assisted breast biopsy (VABB)...
  54. doi request reprint Paget's disease of the breast: the experience of the European Institute of Oncology and review of the literature
    Mujgan Caliskan
    Division of Breast Surgery, European Institute of Oncology, Milan, Italy
    Breast Cancer Res Treat 112:513-21. 2008
    ..The objective of this study was to retrospectively analyze outcome of patients affected by Paget's breast disease and to define our institutional experience...
  55. ncbi request reprint A nomogram based on the expression of Ki-67, steroid hormone receptors status and number of chemotherapy courses to predict pathological complete remission after preoperative chemotherapy for breast cancer
    Marco Colleoni
    Department of Medicine, Research Unit in Medical Senology, European Institute of Oncology, Milan, Italy
    Eur J Cancer 46:2216-24. 2010
    ..Tools able to predict pathological complete response (pCR) to preoperative chemotherapy might improve treatment outcome...
  56. doi request reprint Ductal intraepithelial neoplasia: postsurgical outcome for 1,267 women cared for in one single institution over 10 years
    Aliana Guerrieri-Gonzaga
    Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy
    Oncologist 14:201-12. 2009
    ..We analyzed risk factors and treatment outcome in a large series of women treated at one institution...
  57. doi request reprint Influence of margin status on outcomes in lobular carcinoma: experience of the European Institute of Oncology
    Viviana Galimberti
    Division of Senology, European Institute of Oncology, University of Milan, Milan, Italy
    Ann Surg 253:580-4. 2011
    ..Our aim was to evaluate the influence of margin status on outcomes with a view assessing the appropriateness of conservative surgery in this breast cancer subtype...
  58. ncbi request reprint When sentinel lymph node is intramammary
    Mattia Intra
    Breast Surgery Department, European Institute of Oncology, Via Ripamonti 435, Milan, MI 20141, Italy
    Ann Surg Oncol 15:1304-8. 2008
    ..Little attention has been placed to the presence of intramammary sentinel lymph nodes (intraMSLNs) on preoperative lymphoscintigraphy...
  59. ncbi request reprint Surgical technique of intraoperative radiotherapy in conservative treatment of limited-stage breast cancer
    Mattia Intra
    Breast Division, University of Milan, Italy
    Arch Surg 137:737-40. 2002
    ..In our experience, IORT for limited-stage breast carcinoma is easy to perform and only briefly prolongs the duration of the surgical procedure...
  60. pmc A new option for early breast cancer patients previously irradiated for Hodgkin's disease: intraoperative radiotherapy with electrons (ELIOT)
    Mattia Intra
    Department of Breast Surgery, European Institute of Oncology, Milan, Italy
    Breast Cancer Res 7:R828-32. 2005
    ..Mastectomy is therefore recommended as the first option treatment in these women...
  61. ncbi request reprint The sentinel lymph node biopsy under local anesthesia in breast carcinoma: experience of the European Institute of Oncology and impact on quality of life
    Alberto Luini
    Senology Division, European Institute of Oncology, Milan, Italy
    Breast Cancer Res Treat 89:69-74. 2005
    ..We previously published our preliminary experience with 115 patients; here we present an update of our experience with particular attention devoted to quality of life...
  62. doi request reprint Preoperative concurrent chemo- and endocrine therapies for women with large operable breast cancer expressing steroid hormone receptors
    Rosalba Torrisi
    Research Unit in Medical Senology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Breast 17:654-60. 2008
    ..Endocrine therapy administered together with new intravenous, containing regimens should be explored in the preoperative treatment of endocrine responsive breast cancer...
  63. ncbi request reprint Surgical technique of intraoperative radiation therapy with electrons (ELIOT) in breast cancer: a lesson learned by over 1000 procedures
    Mattia Intra
    Division of Breast Surgery, European Institute of Oncology, University of Milan, Milan, Italy
    Surgery 140:467-71. 2006
  64. doi request reprint Invasive lobular breast cancer: subtypes and outcome
    Monica Iorfida
    Research Unit in Medical Senology, Department of Medicine, European Institute of Oncology, Milan, Italy
    Breast Cancer Res Treat 133:713-23. 2012
    ..The outcome of ILC significantly correlated with histological and immunohistochemically defined molecular subtypes. New tailored strategies should be explored in these subgroups of patients with poor outcome...
  65. doi request reprint Long-term side effects and cosmetic outcome in a pool of breast cancer patients treated with intraoperative radiotherapy with electrons as sole treatment
    Maria Cristina Leonardi
    Division of Radiation Oncology, European Institute of Oncology, Milan, Italy
    Tumori 98:324-30. 2012
    ..To evaluate late toxicity and cosmetic outcome after intraoperative radiotherapy using electrons (ELIOT) as sole treatment modality in early breast cancer patients...
  66. doi request reprint How do the ASTRO consensus statement guidelines for the application of accelerated partial breast irradiation fit intraoperative radiotherapy? A retrospective analysis of patients treated at the European Institute of Oncology
    Maria Cristina Leonardi
    Division of Radiation Oncology, European Institute of Oncology, Milan, Italy
    Int J Radiat Oncol Biol Phys 83:806-13. 2012
    ....
  67. ncbi request reprint Preoperative therapy with trastuzumab and oral vinorelbine (+/- endocrine therapy) in patients with HER2-positive breast cancer
    Monica Iorfida
    Unit of Research in Medical Senology, European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy
    Breast 19:128-32. 2010
    ..Combined trastuzumab and intravenous vinorelbine yielded high clinical activity as preoperative treatment in patients (pts) with HER 2/neu positive breast cancer...
  68. ncbi request reprint Perioperative serum VEGF and extracellular domains of EGFR and HER2 in early breast cancer
    Andrea Rocca
    Research Unit in Medical Senology, Division of Medical Oncology, European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy
    Anticancer Res 29:5111-9. 2009
    ..The prognostic role of serum levels of molecular biomarkers during the perioperative period in patients with early breast cancer is not clear...
  69. ncbi request reprint IART: intraoperative avidination for radionuclide treatment. A new way of partial breast irradiation
    Giovanni Paganelli
    Division of Nuclear Medicine, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Breast 16:17-26. 2007
    ..7 GBq 90Y-biotin (100mCi). A further large clinical trial facing IART in combination with reduced external-beam radiotherapy is, in our opinion, fully justified...
  70. doi request reprint Sentinel lymph node biopsy in multicentric breast cancer: five-year results in a large series from a single institution
    Oreste Gentilini
    Division of Senology, European Institute of Oncology, Milano, Italy
    Ann Surg Oncol 18:2879-84. 2011
    ..This study was designed to present the 5-year results of patients with multicentric breast cancer who underwent sentinel lymph node biopsy (SLNB) in a single institution...
  71. ncbi request reprint Full-dose intraoperative radiotherapy with electrons during breast-conserving surgery
    Umberto Veronesi
    Office of the Scientific Director, Milan, Italy
    Arch Surg 138:1253-6. 2003
    ..Intraoperative RT delivered with electrons at the total isodose of 2100 rad (21 Gy) could in principle substitute the currently used radiation course of external RT after breast-conserving surgery in selected cases...
  72. ncbi request reprint Clinical experience with axillary presentation breast cancer
    Viviana Galimberti
    Department of Senology, European Institute of Oncology, Milan, Italy
    Breast Cancer Res Treat 88:43-7. 2004
    ..We present guidelines for the work-up of patients presenting with axillary disease...
  73. doi request reprint Conservative surgery in patients with multifocal/multicentric breast cancer
    Oreste Gentilini
    Division of Breast Surgery, European Institute of Oncology, Milan, Italy
    Breast Cancer Res Treat 113:577-83. 2009
    ..We retrospectively evaluate outcome of patients with MF/MC cancers who had breast conservation with specific attention on local control and predictive factors of recurrence...
  74. ncbi request reprint Breast carcinoma in elderly women: features of disease presentation, choice of local and systemic treatments compared with younger postmenopasual patients
    Roberto Gennari
    Department of Surgery, European Institute of Oncology, Milan, Italy
    Cancer 101:1302-10. 2004
    ..The aim of the study was to evaluate the relation between biologic features at first diagnosis of breast carcinoma and treatment choice for postmenopausal women > or = 50 years to optimize treatment in the elderly...
  75. doi request reprint No more axillary dissection in patients with ductal intraepithelial neoplasia (DIN)
    Gabriel Farante
    Division of Senology, European Institute of Oncology, 20141 Milan, Italy
    Eur J Cancer 46:476-8. 2010
    ..Even if the SLNB is positive, AD should not be performed immediately but only in cases where an invasive component is found on definitive pathological examination of the DIN lesions...
  76. ncbi request reprint Intraoperative radiotherapy during breast conserving surgery in patients previously treated with radiotherapy for Hodgkin's disease
    Mattia Intra
    Department of Breast Surgery, University of Milan, Italy
    Tumori 90:13-6. 2004
    ..Mastectomy is therefore recommended as the preferred treatment option in these women...
  77. ncbi request reprint Report on a case of breast sarcoma metastatic to the axillary lymph nodes
    Jack Antonio Diaz Brito
    Division of Breast Surgery, European Institute of Oncology, Milan, Italy
    Tumori 92:188-90. 2006
    ..We report a case of a 65-year-old woman affected by follicular dendritic cell sarcoma of the left breast. Six months after breast surgery she developed an axillary metastasis from the same disease...
  78. doi request reprint Intraoperative avidination for radionuclide treatment as a radiotherapy boost in breast cancer: results of a phase II study with (90)Y-labeled biotin
    Giovanni Paganelli
    European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy
    Eur J Nucl Med Mol Imaging 37:203-11. 2010
    ..Reduced duration EBRT (40 Gy) is given subsequently...
  79. ncbi request reprint Changes in circulating tumor cell detection in patients with localized breast cancer before and after surgery
    Maria T Sandri
    Unit of Laboratory Medicine, European Institute of Oncology, Via Ripamonti 435, Milan, Italy
    Ann Surg Oncol 17:1539-45. 2010
    ..If the presence of CTCs in early breast cancer could predict an increased risk for relapse, it might be an early marker for treatment efficacy and could help in deciding treatment continuation...
  80. ncbi request reprint Stage migration after biopsy of internal mammary chain lymph nodes in breast cancer patients
    Viviana Galimberti
    Divisions of Senology, European Institute of Oncology, Milan, Italy
    Ann Surg Oncol 9:924-8. 2002
    ..Use of lymphoscintigraphy to visualize sentinel nodes reveals that IMNs often receive lymph from the area containing the tumor...
  81. ncbi request reprint Biomarkers for risk assessment and prevention of breast cancer
    Massimiliano Cazzaniga
    Division of Cancer Prevention and Genetics, European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy
    Curr Cancer Drug Targets 9:482-99. 2009
    ....
  82. ncbi request reprint Axillary sentinel lymph node biopsy in patients with pure ductal carcinoma in situ of the breast
    Mattia Intra
    Department of Breast Surgery, European Institute of Oncology, Milan, Italy
    Arch Surg 138:309-13. 2003
    ....
  83. ncbi request reprint Full-dose intraoperative radiotherapy with electrons in breast surgery: broadening the indications
    Mattia Intra
    Division of Breast Surgery, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Arch Surg 140:936-9. 2005
    ....
  84. ncbi request reprint Less aggressive surgery and radiotherapy is the way forward
    Alberto Costa
    Division of Breast Surgery, Fondazione Salvatore Maugeri, Via Ferrata 8, 27100 Pavia, Italy
    Curr Opin Oncol 16:523-8. 2004
    ..The progressive reduction of the extension of surgery in the breast and in the axilla is now accompanied by a reduction of the radiation field. This article provides an update on conservative therapy for breast cancer...
  85. ncbi request reprint Chemotherapy is more effective in patients with breast cancer not expressing steroid hormone receptors: a study of preoperative treatment
    Marco Colleoni
    Department of Medicine, European Institute of Oncology, Milan, Italy
    Clin Cancer Res 10:6622-8. 2004
    ..The purpose of this research was to identify factors predicting response to preoperative chemotherapy...
  86. ncbi request reprint The nipple-sparing mastectomy: early results of a feasibility study of a new application of perioperative radiotherapy (ELIOT) in the treatment of breast cancer when mastectomy is indicated
    Jean Yves Petit
    Plastic Surgery Division, European Institute of Oncology, Milan, Italy
    Tumori 89:288-91. 2003
    ..The nipple-sparing mastectomy is performed leaving 5 mm of glandular tissue behind the nipple areola complex to preserve its blood supply. The reconstruction is immediately performed with a prosthesis or an autologous flap...
  87. doi request reprint Low-dose tamoxifen in the treatment of breast ductal intraepithelial neoplasia: results of a large observational study
    A Guerrieri-Gonzaga
    Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy
    Ann Oncol 21:949-54. 2010
    ..Since low-dose tamoxifen showed a favorable modulation of breast cancer biomarkers in phase II trials, a monoinstitutional cohort of women with DIN treated with low-dose tamoxifen or no systemic treatment was analyzed...
  88. pmc Immunodetection of bone marrow micrometastases in breast carcinoma patients and its correlation with primary tumour prognostic features
    S Menard
    Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Br J Cancer 69:1126-9. 1994
    ..Thus, the presence of immunoreactive cells in bone marrow correlates with the expression in the primary tumour of a marker of the metastatic potential of the tumour, the 67 kDa laminin receptor...
  89. ncbi request reprint Radioguided occult lesion localisation (ROLL) and surgical biopsy in breast cancer. Technical aspects
    C De Cicco
    Nuclear Medicine, Radiology, Senology and Pathology Divisions, European Institute of Oncology, Milan, Italy
    Q J Nucl Med 46:145-51. 2002
    ..In this paper technical aspects of ROLL and results on a large series of patients are reported...
  90. ncbi request reprint Intraoperative radiation therapy for breast cancer: technical notes
    Umberto Veronesi
    Breast Department, European Institute of Oncology, Milan, Italy
    Breast J 9:106-12. 2003
    ..Here we report the two different techniques in use in these trials...
  91. ncbi request reprint Sentinel lymph node biopsy and axillary dissection in breast cancer: results in a large series
    U Veronesi
    Senology Division, Istituto Europeo di Oncologia, Milan, Italy
    J Natl Cancer Inst 91:368-73. 1999
    ....
  92. ncbi request reprint Adenomyoepithelioma of the breast, presenting as a cancer
    Giovanna Gatti
    Senology Division, European Oncology Institute, Milan, Italy
    Tumori 90:337-9. 2004
    ..Adenomyoepithelioma is a rare lesion that can involve the breast tissue. The diagnostic appearance of the lesion can give rise to a difficult differential diagnosis with breast carcinoma...
  93. ncbi request reprint A randomized trial of low-dose tamoxifen on breast cancer proliferation and blood estrogenic biomarkers
    Andrea Decensi
    Division of Chemoprevention, European Institute of Oncology, and University of Milan School of Medicine, Milan, Italy
    J Natl Cancer Inst 95:779-90. 2003
    ....
  94. ncbi request reprint Urinary bladder metastases from breast carcinoma: review of the literature starting from a clinical case
    Giovanna Gatti
    Division of Breast Surgery, European Institute of Oncology, Milan, Italy
    Tumori 91:283-6. 2005
    ..Patients with breast cancer presenting with urinary symptoms should be examined for possible bladder metastases...
  95. ncbi request reprint Dendritic cell sarcoma: an analytic overview of the literature and presentation of original five cases
    Tommaso De Pas
    New Drugs Development and Clinical Pharmacology Unit, Department of Medicine, European Institute of Oncology, Milan, Italy
    Crit Rev Oncol Hematol 65:1-7. 2008
    ..Both the analytic revision of the literature and our data suggest that localized DCS may be effectively treated by radical surgery and do not support the use of adjuvant treatments after radical excision...
  96. ncbi request reprint Report on a case of pure cribriform carcinoma of the breast with internal mammary node metastasis: description of the case and review of the literature
    Giovanna Gatti
    Division of Breast Surgery, European Institute of Oncology, Milan, Italy
    Tumori 92:241-3. 2006
    ..Internal mammary node metastases are not frequently detected when the axillary nodes are negative...
  97. ncbi request reprint Male breast cancer: a special therapeutic problem. Anything new? (Review)
    Roberto Gennari
    Department of Surgery, European Institute of Oncology, 20141 Milano, Italy
    Int J Oncol 24:663-70. 2004
    ....
  98. ncbi request reprint HER2 status in early breast cancer: relevance of cell staining patterns, gene amplification and polysomy 17
    Rosalba Torrisi
    Department of Medicine, European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy
    Eur J Cancer 43:2339-44. 2007
    ..Our results suggest that FISH testing should be considered for tumours with 50% positive stained cells and that polysomy 17 without amplification is not associated with poor prognostic features...
  99. doi request reprint Systemic therapy as a first choice treatment for idiopathic granulomatous mastitis
    Fausto Maffini
    Division of Pathology and Laboratory Medicine, European Institute of Oncology, Milan, Italy
    J Cutan Pathol 36:689-91. 2009
    ....
  100. ncbi request reprint Axillary radiotherapy instead of axillary dissection: a randomized trial. Italian Oncological Senology Group
    Stefano Zurrida
    Department of Senology, European Institute of Oncology, Milan, Italy
    Ann Surg Oncol 9:156-60. 2002
    ..We evaluated disease-free and overall survival in patients with early breast cancer treated by breast-conservation surgery without dissection of axillary lymph nodes, receiving or not receiving axillary radiotherapy (RT)...
  101. ncbi request reprint Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer
    Umberto Veronesi
    Department of Senology, European Institute of Oncology, Milan, Italy
    N Engl J Med 347:1227-32. 2002
    ..We conducted 20 years of follow-up of women enrolled in a randomized trial to compare the efficacy of radical (Halsted) mastectomy with that of breast-conserving surgery...