Alberto d'Onofrio

Summary

Affiliation: European Institute of Oncology
Country: Italy

Publications

  1. doi request reprint Information-related changes in contact patterns may trigger oscillations in the endemic prevalence of infectious diseases
    Alberto d'Onofrio
    Division of Epidemiology and Biostatistics, European Institute of Oncology, Via Ripamonti 435, 20141 Milano, Italy
    J Theor Biol 256:473-8. 2009
  2. doi request reprint A family of models of angiogenesis and anti-angiogenesis anti-cancer therapy
    Alberto d'Onofrio
    Epidemiology and Biostatistics Division, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Math Med Biol 26:63-95. 2009
  3. doi request reprint Fatal SIR diseases and rational exemption to vaccination
    Alberto d'Onofrio
    Division of Epidemiology and Biostatistics, European Institute of Oncology, Milano, Italy
    Math Med Biol 25:337-57. 2008
  4. ncbi request reprint Rapidly acting antitumoral antiangiogenic therapies
    Alberto d'Onofrio
    European Institute of Oncology, Division of Epidemiology and Biostatistics, Via Ripamonti 435, I20141 Milano, Italy
    Phys Rev E Stat Nonlin Soft Matter Phys 76:031920. 2007
  5. ncbi request reprint Vaccinating behaviour, information, and the dynamics of SIR vaccine preventable diseases
    Alberto d'Onofrio
    Division of Epidemiology and Biostatistics, European Institute of Oncology, Via Ripamonti 435, 20141 Milano, Italy
    Theor Popul Biol 71:301-17. 2007
  6. doi request reprint Vaccine demand driven by vaccine side effects: dynamic implications for SIR diseases
    Alberto d'Onofrio
    Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milano, Italy
    J Theor Biol 264:237-52. 2010
  7. pmc The interplay of public intervention and private choices in determining the outcome of vaccination programmes
    Alberto d'Onofrio
    Department of Experimental Oncology, European Institute of Oncology, Milano, Italy
    PLoS ONE 7:e45653. 2012
  8. ncbi request reprint Tumour eradication by antiangiogenic therapy: analysis and extensions of the model by Hahnfeldt et al. (1999)
    Alberto d'Onofrio
    Department of Epidemiology and Biostatistics, European Institute of Oncology, Via Ripamonti 435, 20141 Milano, Italy
    Math Biosci 191:159-84. 2004
  9. doi request reprint Chemotherapy of vascularised tumours: role of vessel density and the effect of vascular "pruning"
    Alberto d'Onofrio
    Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milano, Italy
    J Theor Biol 264:253-65. 2010
  10. ncbi request reprint Analysis of mandibular dose distribution in radiotherapy for oropharyngeal cancer: dosimetric and clinical results in 18 patients
    Barbara A Jereczek-Fossa
    Division of Radiation Oncology, European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy
    Radiother Oncol 66:49-56. 2003

Detail Information

Publications24

  1. doi request reprint Information-related changes in contact patterns may trigger oscillations in the endemic prevalence of infectious diseases
    Alberto d'Onofrio
    Division of Epidemiology and Biostatistics, European Institute of Oncology, Via Ripamonti 435, 20141 Milano, Italy
    J Theor Biol 256:473-8. 2009
    ..This indicates that human behavior might be a critical explaining factor of oscillations in time-series of endemic diseases. Finally, we briefly show how the inclusion of seasonal variations in contacts may imply chaos...
  2. doi request reprint A family of models of angiogenesis and anti-angiogenesis anti-cancer therapy
    Alberto d'Onofrio
    Epidemiology and Biostatistics Division, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Math Med Biol 26:63-95. 2009
    ..The destabilizing effect of delays on achieving the tumour eradication is also investigated. Finally, global conditions for stability and eradication in the presence of delays are given for some particular cases...
  3. doi request reprint Fatal SIR diseases and rational exemption to vaccination
    Alberto d'Onofrio
    Division of Epidemiology and Biostatistics, European Institute of Oncology, Milano, Italy
    Math Med Biol 25:337-57. 2008
    ..In particular, we illustrate the onset of the long cycles caused by rational exemption when vaccination decisions are based on delayed informations...
  4. ncbi request reprint Rapidly acting antitumoral antiangiogenic therapies
    Alberto d'Onofrio
    European Institute of Oncology, Division of Epidemiology and Biostatistics, Via Ripamonti 435, I20141 Milano, Italy
    Phys Rev E Stat Nonlin Soft Matter Phys 76:031920. 2007
    ..These results might be of interest in better understanding the causes underlying the contradictory literature on the clinical trials of antiangiogenic therapies...
  5. ncbi request reprint Vaccinating behaviour, information, and the dynamics of SIR vaccine preventable diseases
    Alberto d'Onofrio
    Division of Epidemiology and Biostatistics, European Institute of Oncology, Via Ripamonti 435, 20141 Milano, Italy
    Theor Popul Biol 71:301-17. 2007
    ..Moreover, we show that rational exemption may also become responsible for the onset of sustained oscillations when the decision to vaccinate also depends on the past history of the disease...
  6. doi request reprint Vaccine demand driven by vaccine side effects: dynamic implications for SIR diseases
    Alberto d'Onofrio
    Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milano, Italy
    J Theor Biol 264:237-52. 2010
    ..We finally report some unexpected scenarios caused by trends in vaccine side effects...
  7. pmc The interplay of public intervention and private choices in determining the outcome of vaccination programmes
    Alberto d'Onofrio
    Department of Experimental Oncology, European Institute of Oncology, Milano, Italy
    PLoS ONE 7:e45653. 2012
    ....
  8. ncbi request reprint Tumour eradication by antiangiogenic therapy: analysis and extensions of the model by Hahnfeldt et al. (1999)
    Alberto d'Onofrio
    Department of Epidemiology and Biostatistics, European Institute of Oncology, Via Ripamonti 435, 20141 Milano, Italy
    Math Biosci 191:159-84. 2004
    ....
  9. doi request reprint Chemotherapy of vascularised tumours: role of vessel density and the effect of vascular "pruning"
    Alberto d'Onofrio
    Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milano, Italy
    J Theor Biol 264:253-65. 2010
    ....
  10. ncbi request reprint Analysis of mandibular dose distribution in radiotherapy for oropharyngeal cancer: dosimetric and clinical results in 18 patients
    Barbara A Jereczek-Fossa
    Division of Radiation Oncology, European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy
    Radiother Oncol 66:49-56. 2003
    ..The aim of our study was to analyze the mandibular dose distribution in the patients administered curative radiotherapy for squamous cell carcinoma of the oropharynx. Moreover, the clinical results have been analyzed...
  11. doi request reprint Multifaceted kinetics of immuno-evasion from tumor dormancy
    Alberto d'Onofrio
    Department of Experimental Oncology, European Institute of Oncology, Milano, Italy
    Adv Exp Med Biol 734:111-43. 2013
    ..In addition, we discuss the ideas that population level tumor dormancy may not be a quiescence phenomenon and that dormant tumors can, at least if modulated by the immune system, live a very active and noisy life!..
  12. doi request reprint A generalization of Gompertz law compatible with the Gyllenberg-Webb theory for tumour growth
    Alberto d'Onofrio
    Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, Milano, Italy
    Math Biosci 230:45-54. 2011
    ..Compatibility with the model proposed in [17] is also investigated. Comparisons with some experimental data confirm the practical applicability of the model. Numerical simulations about the method performance are presented...
  13. ncbi request reprint Resistance to antitumor chemotherapy due to bounded-noise-induced transitions
    Alberto d'Onofrio
    Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, I20141 Milano, Italy
    Phys Rev E Stat Nonlin Soft Matter Phys 82:061901. 2010
    ..Finally, we propose to interpret the above phenomena as an unexpected non-genetic kind of resistance to chemotherapy...
  14. doi request reprint The impact of vaccine side effects on the natural history of immunization programmes: an imitation-game approach
    Alberto d'Onofrio
    Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, Milano, Italy
    J Theor Biol 273:63-71. 2011
    ..This disproportion is further increased in highly industrialised countries. Such considerations represent serious challenges for future vaccination programmes...
  15. doi request reprint Anti-VEGF and beyond: shaping a new generation of anti-angiogenic therapies for cancer
    Francesco Bertolini
    Laboratory of Hematology Oncology and Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy
    Drug Discov Today 16:1052-60. 2011
    ....
  16. doi request reprint On optimal delivery of combination therapy for tumors
    Alberto d'Onofrio
    Department of Experimental Oncology, European Institute of Oncology, 20139 Milan, Italy
    Math Biosci 222:13-26. 2009
    ..Then the optimal scheduling of a vessel disruptive agent in combination with a cytotoxic drug is considered as an optimal control problem. Both theoretical and numerical results on the structure of optimal controls are presented...
  17. ncbi request reprint Bounded-noise-induced transitions in a tumor-immune system interplay
    Alberto d'Onofrio
    Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, I20141 Milano, Italy
    Phys Rev E Stat Nonlin Soft Matter Phys 81:021923. 2010
    ..Namely, the transitions are from unimodal density centered at low values of tumor burden to bimodal densities that have a second maximum centered at higher values. However, those transitions depend on the distribution of the noise...
  18. ncbi request reprint Simple biophysical model of tumor evasion from immune system control
    Alberto d'Onofrio
    European Institute of Oncology, Department of Experimental Oncology, Via Ripamonti 435, I 20141 Milano, Italy
    Phys Rev E Stat Nonlin Soft Matter Phys 84:031910. 2011
    ..Numerical simulations of transitory phases complement the theoretical analysis. Implications of the interplay between the above mechanisms and the delivery of immunotherapies are also illustrated...
  19. doi request reprint On the interaction between the immune system and an exponentially replicating pathogen
    Alberto d'Onofrio
    European Institute of Oncology, Department of Experimental Oncology, Via Ripamonti 435, 20141 Milano, Italy
    Math Biosci Eng 7:579-602. 2010
    ..After shortly studying some pathological cases of interest, we include in our model distributed and constant delays and we show that also delays may unstabilize the equilibria...
  20. ncbi request reprint Stability properties of pulse vaccination strategy in SEIR epidemic model
    Alberto d'Onofrio
    Epidemiology and Biostatistics Division, European Institute of Oncology, Via G Ripamonti 435, I 20141, Milan, Italy
    Math Biosci 179:57-72. 2002
    ..Analytically, the GAS of the eradication solutions is studied and it is demonstrated that the above criteria for the LAS guarantee also the GAS...
  21. doi request reprint From the guest editors
    Alberto d'Onofrio
    Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, I 20141 Milan, Italy ieo campus it
    Math Biosci Eng 10:i-ii. 2013
    ..Mathematics, theoretical biophysics and computer sciences are needed to qualitatively and quantitatively interpret experimental and clinical results, in order to make realistic predictions...
  22. doi request reprint Spatiotemporal effects of a possible chemorepulsion of tumor cells by immune system effectors
    Alberto d'Onofrio
    Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, Milano I 20141, Italy
    J Theor Biol 296:41-8. 2012
    ..Med. Biol., 2004]. Our simulations suggest that this mechanism might allow a faster expansion of tumors, and in the concluding remarks we envisage a new possible route of immunoevasion...
  23. doi request reprint Three-dimensional conformal postoperative radiotherapy in patients with parotid tumors: 10 years' experience at the European Institute of Oncology
    Daniela Alterio
    Division of Radiation Oncology, European Institute of Oncology, Milan, Italy
    Tumori 97:328-34. 2011
    ..Salivary gland malignancies are rare. The aim of our study was to investigate radiotherapy-related toxicity and clinical outcome in patients treated at our division with postoperative radiotherapy (pRT) for parotid tumors...
  24. ncbi request reprint A nonlinear mathematical model of cell turnover, differentiation and tumorigenesis in the intestinal crypt
    Alberto d'Onofrio
    Division of Epidemiology and Biostatistics, European Institute of Oncology, Via Ripamonti 435, Milano, Italy I 20141
    J Theor Biol 244:367-74. 2007
    ....