Elisabetta Dejana

Summary

Affiliation: European Institute of Oncology
Country: Italy

Publications

  1. ncbi Women in cell science. Elisabetta Dejana. Interview by Fiona Watt
    Elisabetta Dejana
    J Cell Sci 118:2789-90. 2005
  2. ncbi Epac1 regulates integrity of endothelial cell junctions through VE-cadherin
    Matthijs R H Kooistra
    Department of Physiological Chemistry, Centre for Biomedical Genetics, University Medical Center, Utrecht, The Netherlands
    FEBS Lett 579:4966-72. 2005
  3. pmc Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments
    Maria Grazia Lampugnani
    IFOM, Fondazione Italiana per la Ricerca sul Cancro Institute of Molecular Oncology, University of Milan, 20139 Milan, Italy
    J Cell Biol 174:593-604. 2006
  4. ncbi The control of endothelial cell functions by adherens junctions
    Maria Grazia Lampugnani
    IFOM, FIRC Institute of Molecular Oncology, Milan, Italy
    Novartis Found Symp 283:4-13; discussion 13-7, 238-41. 2007
  5. ncbi Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5
    Andrea Taddei
    FIRC Institute of Molecular Oncology, 20139 Milan, Italy
    Nat Cell Biol 10:923-34. 2008
  6. pmc Abrogation of junctional adhesion molecule-A expression induces cell apoptosis and reduces breast cancer progression
    Masato Murakami
    IFOM, Foundation FIRC Institute of Molecular Oncology, Milan, Italy
    PLoS ONE 6:e21242. 2011
  7. pmc Stable vascular connections and remodeling require full expression of VE-cadherin in zebrafish embryos
    Mercedes Montero-Balaguer
    FIRC Institute of Molecular Oncology, Milan, Italy
    PLoS ONE 4:e5772. 2009
  8. pmc Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo
    Fabrizio Orsenigo
    FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy
    Nat Commun 3:1208. 2012
  9. ncbi The role of adherens junctions and VE-cadherin in the control of vascular permeability
    Elisabetta Dejana
    FIRC Institute of Molecular Oncology, Via Adamello 16, 20139, Italy
    J Cell Sci 121:2115-22. 2008
  10. doi Organization and signaling of endothelial cell-to-cell junctions in various regions of the blood and lymphatic vascular trees
    Elisabetta Dejana
    IFOM, FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy
    Cell Tissue Res 335:17-25. 2009

Detail Information

Publications70

  1. ncbi Women in cell science. Elisabetta Dejana. Interview by Fiona Watt
    Elisabetta Dejana
    J Cell Sci 118:2789-90. 2005
  2. ncbi Epac1 regulates integrity of endothelial cell junctions through VE-cadherin
    Matthijs R H Kooistra
    Department of Physiological Chemistry, Centre for Biomedical Genetics, University Medical Center, Utrecht, The Netherlands
    FEBS Lett 579:4966-72. 2005
    ..From these results we conclude that in human umbilical vein endothelial cells Epac1 controls VE-cadherin-mediated cell junction formation and induces reorganization of the actin cytoskeleton...
  3. pmc Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments
    Maria Grazia Lampugnani
    IFOM, Fondazione Italiana per la Ricerca sul Cancro Institute of Molecular Oncology, University of Milan, 20139 Milan, Italy
    J Cell Biol 174:593-604. 2006
    ..Thus, VEC limits cell proliferation by retaining VEGFR-2 at the membrane and preventing its internalization into signaling compartments...
  4. ncbi The control of endothelial cell functions by adherens junctions
    Maria Grazia Lampugnani
    IFOM, FIRC Institute of Molecular Oncology, Milan, Italy
    Novartis Found Symp 283:4-13; discussion 13-7, 238-41. 2007
    ....
  5. ncbi Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5
    Andrea Taddei
    FIRC Institute of Molecular Oncology, 20139 Milan, Italy
    Nat Cell Biol 10:923-34. 2008
    ..These results offer a molecular basis for the link between AJs and TJs and explain why VE-cadherin inhibition may cause a marked increase in permeability...
  6. pmc Abrogation of junctional adhesion molecule-A expression induces cell apoptosis and reduces breast cancer progression
    Masato Murakami
    IFOM, Foundation FIRC Institute of Molecular Oncology, Milan, Italy
    PLoS ONE 6:e21242. 2011
    ..We conclude that down regulation of JAM-A reduces tumor aggressive behavior by increasing cell susceptibility to apoptosis. JAM-A may be considered a negative prognostic factor and a potential therapeutic target...
  7. pmc Stable vascular connections and remodeling require full expression of VE-cadherin in zebrafish embryos
    Mercedes Montero-Balaguer
    FIRC Institute of Molecular Oncology, Milan, Italy
    PLoS ONE 4:e5772. 2009
    ..However, the mechanism of action of VE-cadherin is complex and, in the mouse embryo, it is difficult to define the specific steps of vascular development in which this protein is involved...
  8. pmc Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo
    Fabrizio Orsenigo
    FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy
    Nat Commun 3:1208. 2012
    ..Thus, phosphorylation of vascular endothelial cadherin contributes to a dynamic state of adherens junctions, but is not sufficient to increase vascular permeability in the absence of inflammatory agents...
  9. ncbi The role of adherens junctions and VE-cadherin in the control of vascular permeability
    Elisabetta Dejana
    FIRC Institute of Molecular Oncology, Via Adamello 16, 20139, Italy
    J Cell Sci 121:2115-22. 2008
    ..We discuss the possible use of inhibitors of SRC and other kinases, of agents that increase cAMP levels, and of inhibitors of lytic enzymes as pharmacological tools for decreasing endothelial permeability...
  10. doi Organization and signaling of endothelial cell-to-cell junctions in various regions of the blood and lymphatic vascular trees
    Elisabetta Dejana
    IFOM, FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy
    Cell Tissue Res 335:17-25. 2009
    ..We emphasize the way that these structures regulate endothelial cell homeostasis by transferring specific intracellular signals and by modulating activation and signaling of growth factor receptors...
  11. ncbi Foxs and Ets in the transcriptional regulation of endothelial cell differentiation and angiogenesis
    Elisabetta Dejana
    IFOM, FIRC Institute of Molecular Oncology, Milan, Italy
    Biochim Biophys Acta 1775:298-312. 2007
    ....
  12. doi The role of wnt signaling in physiological and pathological angiogenesis
    Elisabetta Dejana
    IFOM, Via Adamello 16, 20139 Milano, Italy
    Circ Res 107:943-52. 2010
    ..Continued progress in this field holds the potential to identify novel therapeutics for the treatment of these diseases...
  13. pmc Wnt/beta-catenin signaling controls development of the blood-brain barrier
    Stefan Liebner
    Institute of Neurology Edinger Institute, Johann Wolfgang Goethe University, 60325 Frankfurt, Germany
    J Cell Biol 183:409-17. 2008
    ..These findings may open new therapeutic avenues to modulate endothelial barrier function and to limit the devastating effects of BBB breakdown...
  14. doi The control of vascular integrity by endothelial cell junctions: molecular basis and pathological implications
    Elisabetta Dejana
    IFOM, The FIRC Institute of Molecular Oncology, Milan, Italy
    Dev Cell 16:209-21. 2009
    ..In this review we discuss recent findings derived from these approaches and their possible integration in a common picture...
  15. doi The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling
    Monica Corada
    IFOM, The FIRC Institute of Molecular Oncology Foundation, 20139 Milan, Italy
    Dev Cell 18:938-49. 2010
    ..We propose that early and sustained beta-catenin signaling prevents correct endothelial cell differentiation, altering vascular remodeling and arteriovenous specification...
  16. pmc Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148
    Maria Grazia Lampugnani
    FIRC Institute of Molecular Oncology, 20139 Milan, Italy
    J Cell Biol 161:793-804. 2003
    ..In sparse cells or in VE-cadherin-null cells, this phenomenon cannot occur and the receptor is fully activated by the growth factor...
  17. pmc VE-cadherin is a critical endothelial regulator of TGF-beta signalling
    Noemi Rudini
    Vascular Biology Unit, FIRC Institute of Molecular Oncology, Milan, Italy
    EMBO J 27:993-1004. 2008
    ..This suggests that reduction or inactivation of VE-cadherin may contribute to progression of diseases where TGF-beta signalling is impaired...
  18. pmc The conditional inactivation of the beta-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility
    Anna Cattelino
    FIRC Institute of Molecular Oncology, 16 20139, Milan, Italy
    J Cell Biol 162:1111-22. 2003
    ..This may become more marked when the vessels are exposed to high or turbulent flow, such as at bifurcations or in the beating heart, leading to fluid leakage or hemorrhages...
  19. doi CCM1 regulates vascular-lumen organization by inducing endothelial polarity
    Maria Grazia Lampugnani
    IFOM, FIRC Institute of Molecular Oncology Foundation, 20139 Milan, Italy
    J Cell Sci 123:1073-80. 2010
    ..We propose that VEC, CCM1 and Rap1 form a signaling complex. In the absence of any of these proteins, AJs are dismantled, cell polarity is lost and vascular lumenal structure is severely altered...
  20. pmc VE-cadherin expression and clustering maintain low levels of survivin in endothelial cells
    Monica Iurlaro
    Italian Foundation for Cancer Research, Institute of Molecular Oncology, Milan, Italy
    Am J Pathol 165:181-9. 2004
    ..Consistently, in epidermal and pancreatic cell lines or ovarian tumors, epithelial-cadherin (E-cadherin) and survivin expression is inversely related, suggesting a non-cell-specific role of cadherins in reducing survivin synthesis...
  21. doi JAM-A promotes neutrophil chemotaxis by controlling integrin internalization and recycling
    Maria Rosaria Cera
    FIRC Institute of Molecular Oncology, Milan, Italy
    J Cell Sci 122:268-77. 2009
    ....
  22. doi Overlapping and divergent signaling pathways of N-cadherin and VE-cadherin in endothelial cells
    Costanza Giampietro
    FIRC Institute of Molecular Oncology, University of Milan, Milan, Italy
    Blood 119:2159-70. 2012
    ..We conclude that VE and N-cadherin have both additive and divergent effects on ECs. Differences in signaling are due, in part, to cadherin association with growth factor receptors and modulation of their downstream signaling...
  23. ncbi Sox18 and Sox7 play redundant roles in vascular development
    Solei Cermenati
    Dipartimento di Scienze Biomolecolari e Biotecnologie, Universita degli Studi di Milano, Via Celoria 26, Milan, Italy
    Blood 111:2657-66. 2008
    ..Our data suggest that a defect in arteriovenous identity could be responsible for the formation of telangiectases in patients with HLT...
  24. pmc Beta-catenin is required for endothelial-mesenchymal transformation during heart cushion development in the mouse
    Stefan Liebner
    FIRC Institute of Molecular Oncology, University of Milan, Italy
    J Cell Biol 166:359-67. 2004
    ....
  25. ncbi A monoclonal antibody to vascular endothelial-cadherin inhibits tumor angiogenesis without side effects on endothelial permeability
    Monica Corada
    FIRC Institute of Molecular Oncology, Milan, Italy
    Blood 100:905-11. 2002
    ..In contrast, in growing vessels, where endothelial cells are migrating and junctions are weaker, antibody binding to EC4 may be sufficient to disrupt cell-to-cell adhesion and inhibit assembly of new vascular structures...
  26. doi Inactivation of junctional adhesion molecule-A enhances antitumoral immune response by promoting dendritic cell and T lymphocyte infiltration
    Masato Murakami
    FIRC Institute of Molecular Oncology, Milan, Italy
    Cancer Res 70:1759-65. 2010
    ..These findings support the idea that, in the Rip1Tag2 tumor model, abrogation of JAM-A reduces cancer development by increasing antitumor immune response...
  27. ncbi Downregulation of vascular endothelial-cadherin expression is associated with an increase in vascular tumor growth and hemorrhagic complications
    Lucia Zanetta
    FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy
    Thromb Haemost 93:1041-6. 2005
    ..Overall, these data strongly suggest that downregulation of VE-cadherin in endothelial tumors may have important consequences for tumor growth and bleeding complications...
  28. ncbi Vascular endothelial growth factor induces SHC association with vascular endothelial cadherin: a potential feedback mechanism to control vascular endothelial growth factor receptor-2 signaling
    Adriana Zanetti
    Mario Negri Institute of Pharmacological Research, Milan, Italy
    Arterioscler Thromb Vasc Biol 22:617-22. 2002
    ..These data suggest that VE-cadherin expression exerts a negative effect on Shc phosphorylation by VEGFR-2. We speculate that VE-cadherin binding to Shc promotes its dephosphorylation through associated phosphatases...
  29. ncbi Gas1 is induced by VE-cadherin and vascular endothelial growth factor and inhibits endothelial cell apoptosis
    Raffaella Spagnuolo
    Italian Foundation for Cancer Research FIRC Institute of Molecular Oncology, Milan, Italy
    Blood 103:3005-12. 2004
    ..Gas1 expression positively correlates with inhibition of endothelial cell apoptosis and may contribute to the integrity of resting endothelium...
  30. doi Unique role of junctional adhesion molecule-a in maintaining mucosal homeostasis in inflammatory bowel disease
    Stefania Vetrano
    Division of Gastroenterology, Istituto di Ricerca e Cura a Carattere Scientifico Istituto Clinico Humanitas, University of Milan, Rozzano, Italy
    Gastroenterology 135:173-84. 2008
    ..Junctional adhesion molecule-A (JAM-A) is localized at the tight junctions and controls leukocyte migration into the tissues. However, its functional role in inflammatory bowel disease (IBD) is unexplored...
  31. pmc Junctional adhesion molecule-A-deficient polymorphonuclear cells show reduced diapedesis in peritonitis and heart ischemia-reperfusion injury
    Monica Corada
    Fondazione Italiana per la Ricerca sul Cancro, Institute of Molecular Oncology, 20139 Milan, Italy
    Proc Natl Acad Sci U S A 102:10634-9. 2005
    ..This paper describes a nonredundant role of JAM-A in controlling PMN diapedesis through the vessel wall...
  32. ncbi EndMT contributes to the onset and progression of cerebral cavernous malformations
    Luigi Maddaluno
    IFOM Fondazione, FIRC Institute of Molecular Oncology, 20139 Milan, Italy
    Nature 498:492-6. 2013
    ..These studies offer novel therapeutic opportunities for this severe, and so far incurable, pathology. ..
  33. pmc Wnt activation of immortalized brain endothelial cells as a tool for generating a standardized model of the blood brain barrier in vitro
    Roberta Paolinelli
    IFOM FIRC Institute of Molecular Oncology Foundation, Milan, Italy
    PLoS ONE 8:e70233. 2013
    ..This model may be thus suitable to test the BBB permeability to chemicals or large molecular weight proteins, transmigration of inflammatory cells, treatments with cytokines, and genetic manipulation. ..
  34. pmc Ve-ptp modulates vascular integrity by promoting adherens junction maturation
    Silvia Carra
    Dipartimento di Biologia, Universitàdegli Studi di Milano, Milan, Italy
    PLoS ONE 7:e51245. 2012
    ..Ve-ptp (Vascular Endothelial-Protein Tyrosine Phosphatase) is a transmembrane protein present at endothelial adherens junctions (AJs)...
  35. ncbi Adherens junctions in endothelial cells regulate vessel maintenance and angiogenesis
    Maria Grazia Lampugnani
    IFOM, FIRC Institute of Molecular Oncology, Mario Negri Institute for Pharmacological Research, Milano, Italy
    Thromb Res 120:S1-6. 2007
    ....
  36. doi Endothelial adherens junctions at a glance
    Elisabetta Dejana
    IFOM, Foundation FIRC Institute of Molecular Oncology, Milan, Italy
    J Cell Sci 126:2545-9. 2013
    ..It will be important to achieve a better understanding of the relationship between vascular fragility, malformations and junctional integrity in order to develop more effective therapies. ..
  37. pmc Deciphering the functional role of endothelial junctions by using in vivo models
    Daniel Nyqvist
    IFOM, FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy
    EMBO Rep 9:742-7. 2008
    ..By contrast, the data available suggest that tight-junction proteins are not essential for vascular development but are necessary for endothelial barrier function...
  38. pmc Increased DC trafficking to lymph nodes and contact hypersensitivity in junctional adhesion molecule-A-deficient mice
    Maria Rosaria Cera
    Department of Vascular Biology, Italian Foundation for Cancer Research FIRC Institute of Molecular Oncology, Milan, Italy
    J Clin Invest 114:729-38. 2004
    ..Thus, we identified here a novel, non-redundant role of JAM-A in controlling DC motility, trafficking to lymph nodes, and activation of specific immunity...
  39. ncbi Generation and characterization of a mouse lymphatic endothelial cell line
    Marina Sironi
    Department of Immunology and Cell Biology, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Cell Tissue Res 325:91-100. 2006
    ..Whole genome transcriptional profiling identified a set of 150 known genes differentially expressed in MELC versus vascular endothelial cells. Thus, the MELC line may represent an invaluable source of lymphatic endothelium...
  40. ncbi Mesoangioblasts, vessel-associated multipotent stem cells, repair the infarcted heart by multiple cellular mechanisms: a comparison with bone marrow progenitors, fibroblasts, and endothelial cells
    Daniela Galli
    Stem Cell Research Institute, DIBIT, H San Raffaele, Milan, Italy
    Arterioscler Thromb Vasc Biol 25:692-7. 2005
    ....
  41. doi Adhesion molecule signalling: not always a sticky business
    Ugo Cavallaro
    Cell Adhesion and Signalling, FIRC Institute of Molecular Oncology IFOM, Via Adamello 16, 20139 Milan, Italy
    Nat Rev Mol Cell Biol 12:189-97. 2011
    ..The ability of CAMs to activate signal transduction cascades in the absence of cell adhesion significantly extends their range of biological activities...
  42. doi VE-cadherin and endothelial adherens junctions: active guardians of vascular integrity
    Monica Giannotta
    FIRC Institute of Molecular Oncology, 20129 Milan, Italy
    Dev Cell 26:441-54. 2013
    ..Here we review some of the most important pathways through which VE-cadherin modulates vascular homeostasis and discuss the emerging concepts in the overall biological role of this protein. ..
  43. ncbi Vascular endothelial-cadherin and vascular stability
    Elisabetta Dejana
    IFOM, FIRC Institute of Molecular Oncology, Milan, Italy
    Curr Opin Hematol 19:218-23. 2012
    ..Here, we discuss the current knowledge on the role of endothelial cell-to-cell adherens junctions in maintaining vascular integrity...
  44. pmc Targeting endothelial junctional adhesion molecule-A/ EPAC/ Rap-1 axis as a novel strategy to increase stem cell engraftment in dystrophic muscles
    Monica Giannotta
    FIRC Institute of Molecular Oncology Foundation IFOM, Milan, Italy
    EMBO Mol Med 6:239-58. 2014
    ..Notably, pharmacological inhibition of Rap-1 increases MAB engraftment in dystrophic muscle, which results into a significant improvement of muscle function offering a novel strategy for stem cell-based therapies. ..
  45. doi The molecular basis of the blood brain barrier differentiation and maintenance. Is it still a mystery?
    Roberta Paolinelli
    IFOM, FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy
    Pharmacol Res 63:165-71. 2011
    ..In this review we describe the specific features of the BBB and we discuss recent data on the role of Wnt as a mediator of brain angiogenesis and BBB differentiation...
  46. ncbi VE-cadherin at a glance
    Luca Bravi
    FIRC Institute of Molecular Oncology IFOM Fondazione, Via Adamello 16, 20139, Milan, Italy
    Cell Tissue Res 355:515-22. 2014
    ..This delineates a complex network of molecular and functional interactions that can be altered in pathologies. ..
  47. doi The role of VE-cadherin in vascular morphogenesis and permeability control
    Elisabetta Dejana
    IFOM, FIRC Institute of Molecular Oncology, University of Milan, Milan, Italy
    Prog Mol Biol Transl Sci 116:119-44. 2013
    ..In addition, the current knowledge about how VE-cadhern participates in the regulation of the endothelial barrier in the adult organism is discussed...
  48. ncbi News from the brain: the GPR124 orphan receptor directs brain-specific angiogenesis
    Elisabetta Dejana
    Milan University, Department of Biomolecular Sciences and Biotechnologies, Milan, Italy
    Sci Transl Med 2:58ps53. 2010
    ..These findings add to our knowledge of brain vascularization and may open up possibilities for new therapeutic regimes to treat several diseases, including stroke, brain tumors, and vascular malformations...
  49. ncbi Immune regulation by microvascular endothelial cells: directing innate and adaptive immunity, coagulation, and inflammation
    Silvio Danese
    Instituto di Ricerca e Cura a Carattere Scientifico Istituto Clinico Humanitas, Milan, Italy
    J Immunol 178:6017-22. 2007
    ....
  50. ncbi Endothelial cadherins and tumor angiogenesis
    Ugo Cavallaro
    IFOM FIRC Institute of Molecular Oncology, Italy
    Exp Cell Res 312:659-67. 2006
    ..T cadherin, R-cadherin and VE-cadherin 2 were found in specific regions of the vascular tree but their role in vascular development or angiogenesis is still unclear...
  51. ncbi Selective targeting of angiogenic tumor vasculature by vascular endothelial-cadherin antibody inhibits tumor growth without affecting vascular permeability
    Fang Liao
    ImClone Systems Incorporated, New York, NY 10014, USA
    Cancer Res 62:2567-75. 2002
    ..Our data also suggest that antibody E4G10 recognizes VE-cadherin epitopes that are only accessible on endothelial cells forming new adherens junctions, such as in angiogenic tumor vasculature...
  52. ncbi Skeletal myogenic progenitors in the endothelium of lung and yolk sac
    Maria Gabriella Cusella De Angelis
    Department of Experimental Medicine, University of Pavia, Pavia, Italy
    Exp Cell Res 290:207-16. 2003
    ..The number (or potency to generate skeletal muscle) of these vessels associated cells decreases rapidly with age and is very low in mature animals, possibly correlating with reduced regenerative capacity of adult mammalian tissues...
  53. ncbi The transcellular railway: insights into leukocyte diapedesis
    Elisabetta Dejana
    Nat Cell Biol 8:105-7. 2006
  54. ncbi Opposite effects of tumor necrosis factor and soluble fibronectin on junctional adhesion molecule-A in endothelial cells
    Ofelia M Martinez-Estrada
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I 20157 Milan, Italy
    Am J Physiol Lung Cell Mol Physiol 288:L1081-8. 2005
    ..We found that fibronectin reduces the effect of TNF on the disassembly of JAM-A, but not on its dispersal, thus further stressing that disassembly and dispersal can be functionally dissociated...
  55. ncbi Junctional adhesion molecule-A deficiency increases hepatic ischemia-reperfusion injury despite reduction of neutrophil transendothelial migration
    Andrej Khandoga
    Institute for Surgical Research, Ludwig Maximilians University of Munich, Marchioninistr 27, D 81377 Munich, Germany
    Blood 106:725-33. 2005
    ..JAM-A deficiency does not reduce I/R-induced microvascular and hepatocellular necrotic injury, but increases hepatocyte apoptosis, despite attenuation of neutrophil infiltration...
  56. ncbi VE-cadherin is not required for the formation of nascent blood vessels but acts to prevent their disassembly
    Christopher V Crosby
    Cardiovascular Developmental Biology Center, Department of Cell Biology, Medical University of South Carolina, 173 Ashley Ave, Charleston, SC 29425, USA
    Blood 105:2771-6. 2005
    ....
  57. ncbi Contribution of JAM-1 to epithelial differentiation and tight-junction biogenesis in the mouse preimplantation embryo
    Fay C Thomas
    School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, SO16 7PX, UK
    J Cell Sci 117:5599-608. 2004
    ....
  58. ncbi Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis
    Gianfranco Bazzoni
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I 20157 Milan, Italy
    Physiol Rev 84:869-901. 2004
    ..Finally, we analyze in vivo studies and highlight information that specifically relates to the role of junctions in vascular endothelial cells...
  59. ncbi Endothelial cell-cell junctions: happy together
    Elisabetta Dejana
    Department of Biomolecular and Biotechnological Sciences, School of Sciences, Milan University, Italy
    Nat Rev Mol Cell Biol 5:261-70. 2004
  60. pmc Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall
    Per Lindblom
    Department of Medical Biochemistry, Goteborg University, Göteborg SE 405 30, Sweden
    Genes Dev 17:1835-40. 2003
    ..We conclude that retention of PDGF-B in microvessels is essential for proper recruitment and organization of pericytes and for renal and retinal function in adult mice...
  61. pmc VEGF receptor 2 and the adherens junction as a mechanical transducer in vascular endothelial cells
    Ayelet Shay-Salit
    Department of Anatomy and Cell Biology, Bruce Rappaport Research Institute and the Rappaport Faculty of Medicine, Technion, Haifa 31096, Israel
    Proc Natl Acad Sci U S A 99:9462-7. 2002
    ..These results suggest that VEGF receptor 2 and the adherens junction act as shear-stress cotransducers, mediating the transduction of shear-stress signals into vascular endothelial cells...
  62. ncbi Endoglin null endothelial cells proliferate faster and are more responsive to transforming growth factor beta1 with higher affinity receptors and an activated Alk1 pathway
    Nadia Pece-Barbara
    Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    J Biol Chem 280:27800-8. 2005
    ..Thus an altered balance in TGFbeta receptors and downstream Smad pathways may underlie defects in vascular development and homeostasis...
  63. pmc Histone deacetylase activity is essential for the expression of HoxA9 and for endothelial commitment of progenitor cells
    Lothar Rossig
    Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, 60590 Frankfurt am Main, Germany
    J Exp Med 201:1825-35. 2005
    ..Thus, HoxA9 is regulated by HDACs and is critical for postnatal neovascularization...
  64. pmc Transcription factor Erg regulates angiogenesis and endothelial apoptosis through VE-cadherin
    Graeme M Birdsey
    National Heart and Lung Institute Cardiovascular Sciences Unit, Hammersmith Hospital, Imperial College London, UK
    Blood 111:3498-506. 2008
    ..These results identify a new pathway regulating angiogenesis and endothelial survival, via the transcription factor Erg and the adhesion molecule VE-cadherin...
  65. pmc Phosphorylation of vascular endothelial cadherin controls lymphocyte emigration
    Patric Turowski
    Division of Cell Biology, Institute of Ophthalmology, University College London, 11 43 Bath Street, London, EC1V 9EL, UK
    J Cell Sci 121:29-37. 2008
    ..Taken together, these results demonstrate that phosphorylation of adherens junctions constitutes a molecular endpoint of lymphocyte-induced vascular EC signaling and may be exploited as a new target of anti-inflammatory therapies...
  66. pmc SIRT1 controls endothelial angiogenic functions during vascular growth
    Michael Potente
    Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, 60590 Frankfurt, Germany
    Genes Dev 21:2644-58. 2007
    ..These findings uncover a novel and unexpected role for SIRT1 as a critical modulator of endothelial gene expression governing postnatal vascular growth...
  67. ncbi The role of junctional adhesion molecules in vascular inflammation
    Christian Weber
    Institute for Molecular Cardiovascular Research, RWTH University Hospital, 52074 Aachen, Germany
    Nat Rev Immunol 7:467-77. 2007
    ..This Review summarizes recent progress and future directions in understanding the role of JAMs as 'gate keepers' in inflammation and vascular pathology...
  68. ncbi Hepatocyte-conditioned medium sustains endothelial differentiation of human hematopoietic-endothelial progenitors
    Veronica Bordoni
    National Institute for Infectious Diseases L Spallanzani, IRCCS, Rome, Italy
    Hepatology 45:1218-28. 2007
    ....
  69. ncbi Increase in vascular permeability and vasodilation are critical for proangiogenic effects of stem cell therapy
    Dong You
    Cardiovascular Research Center, INSERM U689, Hopital Lariboisiere, 41 Boulevard de la Chapelle, 75475 Paris Cedex 10, France
    Circulation 114:328-38. 2006
    ..However, mechanisms leading to the beneficial effects of BMCs and EPCs remain unclear...
  70. pmc VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of Tiam
    Maria Grazia Lampugnani
    Mario Negri Institute for Pharmacological Research, 20157 Milan, Italy
    Mol Biol Cell 13:1175-89. 2002
    ..Through this mechanism VEC may influence the constitutive organization of the actin cytoskeleton...