Fabrizio d'Adda di Fagagna

Summary

Affiliation: European Institute of Oncology
Country: Italy

Publications

  1. doi request reprint Living on a break: cellular senescence as a DNA-damage response
    Fabrizio d'Adda di Fagagna
    IFOM Foundation, FIRC Institute of Molecular Oncology Foundation, Via Adamello 16, 20139 Milan, Italy
    Nat Rev Cancer 8:512-22. 2008
  2. doi request reprint SASPense and DDRama in cancer and ageing
    Marzia Fumagalli
    Marzia Fumagalli and Fabrizio d Adda di Fagagna are at the IFOM Foundation FIRC Institute of Molecular Oncology Foundation, Via Adamello 16, 20139 Milan, Italy
    Nat Cell Biol 11:921-3. 2009
  3. ncbi request reprint Functional links between telomeres and proteins of the DNA-damage response
    Fabrizio d'Adda di Fagagna
    IFOM Foundation The FIRC Institute of Molecular Oncology Foundation, 20139 Milan, Italy
    Genes Dev 18:1781-99. 2004
  4. pmc Site-specific DICER and DROSHA RNA products control the DNA-damage response
    Sofia Francia
    IFOM Foundation FIRC Institute of Molecular Oncology Foundation, Via Adamello 16, 20139 Milan, Italy
    Nature 488:231-5. 2012
  5. pmc Never-ageing cellular senescence
    Müge Oğrünç
    IFOM Foundation, FIRC Institute of Molecular Oncology Foundation, Milan, Italy
    Eur J Cancer 47:1616-22. 2011
  6. ncbi request reprint A DNA damage checkpoint response in telomere-initiated senescence
    Fabrizio d'Adda di Fagagna
    1 The Wellcome Trust Cancer Research UK Institute of Cancer and Developmental Biology, University of Cambridge, Cambridge CB2 1QR, UK 2 Present address IFOM FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy
    Nature 426:194-8. 2003
  7. ncbi request reprint Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
    Raffaella Di Micco
    IFOM Foundation FIRC Institute of Molecular Oncology Foundation, 20139 Milan, Italy
    Nature 444:638-42. 2006
  8. doi request reprint Is cellular senescence an example of antagonistic pleiotropy?
    Stefano Giaimo
    IFOM Foundation The FIRC Institute of Molecular Oncology Foundation via Adamello 16, 20139 Milan, Italy
    Aging Cell 11:378-83. 2012

Collaborators

Detail Information

Publications8

  1. doi request reprint Living on a break: cellular senescence as a DNA-damage response
    Fabrizio d'Adda di Fagagna
    IFOM Foundation, FIRC Institute of Molecular Oncology Foundation, Via Adamello 16, 20139 Milan, Italy
    Nat Rev Cancer 8:512-22. 2008
    ....
  2. doi request reprint SASPense and DDRama in cancer and ageing
    Marzia Fumagalli
    Marzia Fumagalli and Fabrizio d Adda di Fagagna are at the IFOM Foundation FIRC Institute of Molecular Oncology Foundation, Via Adamello 16, 20139 Milan, Italy
    Nat Cell Biol 11:921-3. 2009
    ..Upstream elements of the DDR cascade are necessary for full blown SASP, and additional crosstalk occurs between the DDR and cytokine secretion...
  3. ncbi request reprint Functional links between telomeres and proteins of the DNA-damage response
    Fabrizio d'Adda di Fagagna
    IFOM Foundation The FIRC Institute of Molecular Oncology Foundation, 20139 Milan, Italy
    Genes Dev 18:1781-99. 2004
    ..In this review, we discuss the current knowledge of both the telomere and the DDR, and then propose an integrated model for the events associated with the metabolism of DNA ends in these two distinct physiological contexts...
  4. pmc Site-specific DICER and DROSHA RNA products control the DNA-damage response
    Sofia Francia
    IFOM Foundation FIRC Institute of Molecular Oncology Foundation, Via Adamello 16, 20139 Milan, Italy
    Nature 488:231-5. 2012
    ..Our results describe an unanticipated direct role of a novel class of ncRNAs in the control of DDR activation at sites of DNA damage...
  5. pmc Never-ageing cellular senescence
    Müge Oğrünç
    IFOM Foundation, FIRC Institute of Molecular Oncology Foundation, Milan, Italy
    Eur J Cancer 47:1616-22. 2011
    ..In this short review, we summarise the many cellular pathways leading to cellular senescence and we discuss the latest experimental evidence and the questions emerging in the field...
  6. ncbi request reprint A DNA damage checkpoint response in telomere-initiated senescence
    Fabrizio d'Adda di Fagagna
    1 The Wellcome Trust Cancer Research UK Institute of Cancer and Developmental Biology, University of Cambridge, Cambridge CB2 1QR, UK 2 Present address IFOM FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy
    Nature 426:194-8. 2003
    ..Thus, we propose that telomere-initiated senescence reflects a DNA damage checkpoint response that is activated with a direct contribution from dysfunctional telomeres...
  7. ncbi request reprint Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
    Raffaella Di Micco
    IFOM Foundation FIRC Institute of Molecular Oncology Foundation, 20139 Milan, Italy
    Nature 444:638-42. 2006
    ..Last, we show that oncogene activation is associated with DDR activation in a mouse model in vivo. We propose that OIS results from the enforcement of a DDR triggered by oncogene-induced DNA hyper-replication...
  8. doi request reprint Is cellular senescence an example of antagonistic pleiotropy?
    Stefano Giaimo
    IFOM Foundation The FIRC Institute of Molecular Oncology Foundation via Adamello 16, 20139 Milan, Italy
    Aging Cell 11:378-83. 2012
    ....