Francesco Blasi

Summary

Affiliation: European Institute of Oncology
Country: Italy

Publications

  1. pmc Myb-binding protein 1A (MYBBP1A) is essential for early embryonic development, controls cell cycle and mitosis, and acts as a tumor suppressor
    Silvia Mori
    Universita Vita Salute San Raffaele, Milan, Italy
    PLoS ONE 7:e39723. 2012
  2. pmc Elevated urinary levels of urokinase-type plasminogen activator receptor (uPAR) in pancreatic ductal adenocarcinoma identify a clinically high-risk group
    Claudio Sorio
    Department of Pathology and Diagnostics, University of Verona, Italy
    BMC Cancer 11:448. 2011
  3. doi The urokinase receptor: focused cell surface proteolysis, cell adhesion and signaling
    Francesco Blasi
    Universita Vita Salute San Raffaele, Milano, Italy
    FEBS Lett 584:1923-30. 2010
  4. ncbi The urokinase receptor in hematopoietic stem cells mobilization
    Francesco Blasi
    San Raffaele Scientific Institute, Via Olgettina 60, Milano 20132 Italy
    Curr Pharm Des 17:1911-3. 2011
  5. ncbi Inhibition of HIV replication by the plasminogen activator is dependent on vitronectin-mediated cell adhesion
    Chiara Elia
    DIBIT, AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute, Via Olgettina, 58, 20132, Milan, Italy
    J Leukoc Biol 82:1212-20. 2007
  6. pmc Ligand-engaged urokinase-type plasminogen activator receptor and activation of the CD11b/CD18 integrin inhibit late events of HIV expression in monocytic cells
    Massimo Alfano
    AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute, Milan, Italy
    Blood 113:1699-709. 2009
  7. ncbi Acute tonsillopharyngitis associated with atypical bacterial infection in children: natural history and impact of macrolide therapy
    Susanna Esposito
    Institute of Pediatrics, University of Milan, Milano, Italy
    Clin Infect Dis 43:206-9. 2006
  8. ncbi Domain 2 of the urokinase receptor contains an integrin-interacting epitope with intrinsic signaling activity: generation of a new integrin inhibitor
    Bernard Degryse
    Department of Molecular Biology and Functional Genomics, DIBIT, Universita Vita Salute San Raffaele, Via Olgettina 58, 20132 Milan, Italy
    J Biol Chem 280:24792-803. 2005
  9. ncbi Specific immunofluorimetric assay detecting the chemotactic epitope of the urokinase receptor (uPAR)
    Massimo Resnati
    Laboratory of Molecular Genetics, DIBIT, H San Raffaele and Università Vita Salute San Raffaele, Via Olgettina 58, 20132, Milano, Italy
    J Immunol Methods 308:192-202. 2006
  10. ncbi Purification of the Prep1 interactome identifies novel pathways regulated by Prep1
    Victor M Diaz
    Molecular Genetics Unit, Department of Molecular Biology and Functional Genomics, Università Vita Salute San Raffaele and DIBIT, H San Raffaele, Milan, Italy
    Proteomics 7:2617-23. 2007

Collaborators

Detail Information

Publications65

  1. pmc Myb-binding protein 1A (MYBBP1A) is essential for early embryonic development, controls cell cycle and mitosis, and acts as a tumor suppressor
    Silvia Mori
    Universita Vita Salute San Raffaele, Milan, Italy
    PLoS ONE 7:e39723. 2012
    ..We conclude that MYBBP1A is an essential gene with novel roles at the pre-mitotic level and potential tumor suppressor activity...
  2. pmc Elevated urinary levels of urokinase-type plasminogen activator receptor (uPAR) in pancreatic ductal adenocarcinoma identify a clinically high-risk group
    Claudio Sorio
    Department of Pathology and Diagnostics, University of Verona, Italy
    BMC Cancer 11:448. 2011
    ..It is unknown whether the level of its soluble form (suPAR) in urine may be a diagnostic-prognostic marker in these patients...
  3. doi The urokinase receptor: focused cell surface proteolysis, cell adhesion and signaling
    Francesco Blasi
    Universita Vita Salute San Raffaele, Milano, Italy
    FEBS Lett 584:1923-30. 2010
    ..uPAR regulates the cells-extracellular matrix interactions promoting its degradation and turnover through the plasminogen activation cascade...
  4. ncbi The urokinase receptor in hematopoietic stem cells mobilization
    Francesco Blasi
    San Raffaele Scientific Institute, Via Olgettina 60, Milano 20132 Italy
    Curr Pharm Des 17:1911-3. 2011
    ..Available data suggest that a similar mechanism may take place in humans...
  5. ncbi Inhibition of HIV replication by the plasminogen activator is dependent on vitronectin-mediated cell adhesion
    Chiara Elia
    DIBIT, AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute, Via Olgettina, 58, 20132, Milan, Italy
    J Leukoc Biol 82:1212-20. 2007
    ..In conclusion, uPA inhibits HIV-1 replication in macrophages via up-regulation of cell adhesion to the substrate mediated by VN...
  6. pmc Ligand-engaged urokinase-type plasminogen activator receptor and activation of the CD11b/CD18 integrin inhibit late events of HIV expression in monocytic cells
    Massimo Alfano
    AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute, Milan, Italy
    Blood 113:1699-709. 2009
    ..Thus, either uPA/uPAR interaction, Mac-1 activation, or prevention of its association with uPAR triggers a signaling pathway leading to the inefficient release of HIV from monocytic cells...
  7. ncbi Acute tonsillopharyngitis associated with atypical bacterial infection in children: natural history and impact of macrolide therapy
    Susanna Esposito
    Institute of Pediatrics, University of Milan, Milano, Italy
    Clin Infect Dis 43:206-9. 2006
    ..pneumoniae and C. pneumoniae may have a negative outcome with a high risk of recurrence of respiratory illness...
  8. ncbi Domain 2 of the urokinase receptor contains an integrin-interacting epitope with intrinsic signaling activity: generation of a new integrin inhibitor
    Bernard Degryse
    Department of Molecular Biology and Functional Genomics, DIBIT, Universita Vita Salute San Raffaele, Via Olgettina 58, 20132 Milan, Italy
    J Biol Chem 280:24792-803. 2005
    ..This sequence thus plays a pivotal role in the regulation of uPAR-integrin interactions. Moreover, we describe a novel, very potent inhibitor of integrin-dependent cell migration...
  9. ncbi Specific immunofluorimetric assay detecting the chemotactic epitope of the urokinase receptor (uPAR)
    Massimo Resnati
    Laboratory of Molecular Genetics, DIBIT, H San Raffaele and Università Vita Salute San Raffaele, Via Olgettina 58, 20132, Milano, Italy
    J Immunol Methods 308:192-202. 2006
    ..The immunofluorimetric assay will quantitate uPAR chemotactic fragments in biological samples, including serum and urine, and evaluate their diagnostic or prognostic potential in clinical studies...
  10. ncbi Purification of the Prep1 interactome identifies novel pathways regulated by Prep1
    Victor M Diaz
    Molecular Genetics Unit, Department of Molecular Biology and Functional Genomics, Università Vita Salute San Raffaele and DIBIT, H San Raffaele, Milan, Italy
    Proteomics 7:2617-23. 2007
    ..The Prep1-TAP complex included Pbx1b, Pbx2, and other nonhomeodomain proteins: p160 Myb-binding protein (p160), beta-actin, NMMHCIIA...
  11. ncbi The homeodomain transcription factor Prep1 (pKnox1) is required for hematopoietic stem and progenitor cell activity
    Patrizia Di Rosa
    Laboratory of Molecular Genetics, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milano, Italy
    Dev Biol 311:324-34. 2007
    ..1(+) (KSLA) cells and B-lymphocytes precursors agrees with the observed phenotype. We therefore conclude that Prep1 is required for a correct and complete hematopoiesis...
  12. pmc Cytosolic sequestration of Prep1 influences early stages of T cell development
    Dmitry Penkov
    Molecular Genetics Unit, San Raffaele Scientific Institute and Universita Vita Salute San Raffaele, Milan, Italy
    PLoS ONE 3:e2424. 2008
    ..To further investigate the role of this homeodomain DNA-binding protein in T cell development, we generated transgenic mice expressing the N-terminal fragment of Pbx1 (Pbx1NT) under the control of the Lck proximal promoter...
  13. pmc Severe asthma exacerbation: role of acute Chlamydophila pneumoniae and Mycoplasma pneumoniae infection
    Roberto Cosentini
    Emergency Medicine Department, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Gruppo NIV Policlinico, Milan, Italy
    Respir Res 9:48. 2008
    ..Chlamydophila pneumoniae and Mycoplasma pneumoniae are associated with acute exacerbation of bronchial asthma (AEBA). The aim of this study was to evaluate the correlation between these acute bacterial infections and the severity of AEBA...
  14. doi The absence of Prep1 causes p53-dependent apoptosis of mouse pluripotent epiblast cells
    Luis C Fernandez-Diaz
    IFOM, FIRC Institute of Molecular Oncology Foundation, IFOM IEO Campus, Via Adamello 16, Milan, Italy
    Development 137:3393-403. 2010
    ..Despite this early lethal phenotype, Prep1 is not essential for ES cell establishment. A differential embryonic expression pattern underscores the unique function of Prep1 within the Meis-Prep family...
  15. pmc Down syndrome fibroblasts and mouse Prep1-overexpressing cells display increased sensitivity to genotoxic stress
    Nicola Micali
    Laboratory of Molecular Dynamics of the Nucleus, Division of Genetics and Cell Biology, S Raffaele Scientific Institute, Via Olgettina 60, Milan, Italy
    Nucleic Acids Res 38:3595-604. 2010
    ..Our results provide a rationale for the involvement of PREP1 in the apoptotic phenotype of DS tissues and indicate that differences in Prep1 level can have drastic effects...
  16. ncbi The role of urokinase-type plasminogen activator (uPA)/uPA receptor in HIV-1 infection
    Massimo Alfano
    Department of Immunology and Infectious Disease, Vita Salute University School of Medicine, Milan, Italy
    J Leukoc Biol 74:750-6. 2003
    ..Which signaling coreceptor(s) is(are) responsible for uPA-dependent anti-HIV effect remains currently undefined...
  17. pmc Monomer dimer dynamics and distribution of GPI-anchored uPAR are determined by cell surface protein assemblies
    Valeria R Caiolfa
    Department of Molecular Biology and Functional Genomics, Unit of Molecular Neuroscience, San Raffaele Scientific Institute, 20132 Milano, Italy
    J Cell Biol 179:1067-82. 2007
    ..These results also provide a strong rationale for dynamic studies of GPI-anchored molecules in live cells at steady state and in the absence of cross-linker/clustering agents...
  18. ncbi Expression of the urokinase plasminogen activator and its receptor in HIV-1-associated central nervous system disease
    Nicolai Sidenius
    Molecular Genetics Unit, DIBIT, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    J Neuroimmunol 157:133-9. 2004
    ..Additionally, these findings are consistent with a model in which overexpression of uPAR and overproduction of its soluble form may promote HIV replication via binding and removal of uPA from cell surface...
  19. pmc Prulifloxacin: a brief review of its potential in the treatment of acute exacerbation of chronic bronchitis
    Francesco Blasi
    Institute of Respiratory Diseases, University of Milan, Fondazione IRCCS Policlinico Mangiagalli Regina Elena, Milano, Italy
    Int J Chron Obstruct Pulmon Dis 2:27-31. 2007
    ..This review discusses the most recent data on the new fluoroquinolone prulifloxacin and critically analyses its activity and safety in the management of AECB...
  20. pmc Cytoplasmic Prep1 interacts with 4EHP inhibiting Hoxb4 translation
    J Carlos Villaescusa
    IFOM, FIRC Institute of Molecular Oncology, Milano, Italy
    PLoS ONE 4:e5213. 2009
    ..Interestingly, Prep1 contains a putative binding motif for 4EHP, which may reflect a novel unknown function...
  21. doi Long-term azithromycin use in patients with chronic obstructive pulmonary disease and tracheostomy
    Francesco Blasi
    Dipartimento Toraco polmonare e Cardio circolatorio, University of Milan, IRCCS Fondazione Po Ma Re, Milan, Italy
    Pulm Pharmacol Ther 23:200-7. 2010
    ..Long-term azithromycin treatment seems to be safe and effective in severe COPD outpatients with tracheostomy in reducing exacerbations, hospitalizations, as well as in improving quality of life...
  22. ncbi Pertussis toxin B-oligomer suppresses IL-6 induced HIV-1 and chemokine expression in chronically infected U1 cells via inhibition of activator protein 1
    Chiara Rizzi
    AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute, Milan, Italy
    J Immunol 176:999-1006. 2006
    ..Thus, PTX-B suppression of IL-6 induced expression of HIV and cellular genes in chronically infected promonocytic cells is strongly correlated to inhibition of AP-1...
  23. ncbi uPA binding increases UPAR localization to lipid rafts and modifies the receptor microdomain composition
    Macarena Sahores
    Molecular Genetics Unit, DIBIT, H S Raffaele, Department of Molecular Biology and Functional Genomics, Universita Vita Salute San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Biochim Biophys Acta 1778:250-9. 2008
    ..However, after treatment of cells with uPA or ATF the lipid environment is strongly impoverished of neutral glycosphingolipids...
  24. pmc Reduction of Prep1 levels affects differentiation of normal and malignant B cells and accelerates Myc driven lymphomagenesis
    Giorgio Iotti
    Laboratory of Transcriptional Regulation in Development and Cancer, Fondazione Istituto FIRC di Oncologia Molecolare, Milano, Italy
    PLoS ONE 7:e48353. 2012
    ..Therefore, the tumor-suppressive activity of Prep1 is intertwined with both the interference with Myc-induced apoptosis as well as with natural developmental functions of the protein...
  25. pmc Chlamydophila pneumoniae induces a sustained airway hyperresponsiveness and inflammation in mice
    Francesco Blasi
    Institute of Respiratory Diseases, University of Milan, IRCCS Ospedale Maggiore Fondazione Policlinico Mangiagalli Regina Elena, Milano, Italy
    Respir Res 8:83. 2007
    ..pneumoniae is involved in the initiation and promotion of asthma and chronic obstructive pulmonary diseases (COPD). Surprisingly, the effect of C. pneumoniae on airway function has never been investigated...
  26. ncbi Metalloproteases cleave the urokinase-type plasminogen activator receptor in the D1-D2 linker region and expose epitopes not present in the intact soluble receptor
    Annapaola Andolfo
    Department of Molecular Pathology and Medicine, Molecular Genetics Unit, DIBIT, San Raffaele Scientific Institute, Milan, Italy
    Thromb Haemost 88:298-306. 2002
    ..Using an antibody raised against the human uPAR linker region we show that this region of uPAR, which contains the chemotactic SRSRY epitope, is exposed upon MMP cleavage...
  27. doi uPAR-deficient mouse keratinocytes fail to produce EGFR-dependent laminin-5, affecting migration in vivo and in vitro
    Silvia D'Alessio
    Università Vita Salute San Raffaele and Istituto Scientifico H San Raffaele, Via Olgettina 60, 20132 Milano, Italy
    J Cell Sci 121:3922-32. 2008
    ..These results were confirmed in vivo, with LN5 being upregulated during wound healing in wild-type but not in uPAR-KO epidermis...
  28. pmc Involvement of Prep1 in the alphabeta T-cell receptor T-lymphocytic potential of hematopoietic precursors
    Dmitri Penkov
    Molecular Genetics Unit, Universita Vita Salute San Raffaele, Milan, Italy
    Mol Cell Biol 25:10768-81. 2005
    ..Therefore, the deficient postnatal T-lymphocytic potential of the Prep1 hematopoietic progenitors depends on the combined, not compensated, absence of Prep1 and at least Pbx2...
  29. pmc How air pollution influences clinical management of respiratory diseases. A case-crossover study in Milan
    Pierachille Santus
    Dipartimento di Scienze della Salute, Universita degli Studi di Milano, Respiratory Unit, San Paolo Hospital, Milan, Italy
    Respir Res 13:95. 2012
    ..We investigated the correlation between emergency room admissions (ERAs) of the general population for respiratory diseases and the environmental pollutant levels in Milan, a metropolis in northern Italy...
  30. ncbi Metabolism of tumour-derived urokinase receptor and receptor fragments in cancer patients and xenografted mice
    Cornelis F M Sier
    Department of Molecular Biology and Functional Genomics and FIRC Institute of Molecular Oncology, San Raffaele Scientific Institute and Hospital, Milan, Italy
    Thromb Haemost 91:403-11. 2004
    ..Considering the biological activities that uPAR fragments display, the level and typing of uPAR fragments in urine might therefore be clinically more relevant than the plain serum uPAR content...
  31. pmc Prep1 directly regulates the intrinsic apoptotic pathway by controlling Bcl-XL levels
    Nicola Micali
    Laboratory of Molecular Genetics, DIBIT, S Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    Mol Cell Biol 29:1143-51. 2009
    ..Thus, Prep1 directly controls mitochondrial homeostasis (and the apoptotic potential) by modulating Bcl-x gene expression...
  32. pmc Hoxb1 enhancer and control of rhombomere 4 expression: complex interplay between PREP1-PBX1-HOXB1 binding sites
    Elisabetta Ferretti
    Molecular Genetics Unit, Department of Molecular Biology and Functional Genomics, Istituto Scientifico H San Raffaele, Universita Vita Salute San Raffaele, Via Olgettina 58, 20132 Milan, Italy
    Mol Cell Biol 25:8541-52. 2005
    ....
  33. doi The role of biomarkers in low respiratory tract infections
    Francesco Blasi
    Dipartimento Toraco polmonare e Cardio circolatorio, University of Milan, IRCCS Fondazione Cà Granda Ospedale Maggiore Policlinico, Via F Sforza 35, Milan, Italy
    Eur J Intern Med 23:429-35. 2012
    ....
  34. ncbi The urokinase receptor and the regulation of cell proliferation
    Roberta Mazzieri
    Universita Vita Salute San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Thromb Haemost 93:641-6. 2005
    ..Alteration of such a complex and finely modulated mechanism results in unregulated cell proliferation and altered tissue organization, typically associated with tumor progression...
  35. ncbi The urokinase receptor is overexpressed in the AIDS dementia complex and other neurological manifestations
    Paola Cinque
    Clinic of Infectious Diseases, San Raffaele Scientific Institute, University of Milan, Italy
    Ann Neurol 55:687-94. 2004
    ..The overexpression of uPAR in the CNS of patients with ADC suggests that the uPA/uPAR system may contribute to the tissue injury and neuronal damage in this disease...
  36. pmc Urokinase-urokinase receptor interaction mediates an inhibitory signal for HIV-1 replication
    Massimo Alfano
    AIDS Immunopathogenesis Unit, Department of Immunology and Infectious Diseases, San Raffaele Scientific Institute, Via Olgettina n 58, 20132 Milan, Italy
    Proc Natl Acad Sci U S A 99:8862-7. 2002
    ....
  37. ncbi The soluble D2D3(88-274) fragment of the urokinase receptor inhibits monocyte chemotaxis and integrin-dependent cell adhesion
    Federico Furlan
    Department of Molecular Biology and Functional Genomics, San Raffaele Scientific Institute, Milan, 20132, Italy
    J Cell Sci 117:2909-16. 2004
    ....
  38. doi Bronchodilators modulate inflammation in chronic obstructive pulmonary disease subjects
    Pierachille Santus
    Universita degli Studi di Milano, Dipartimento di Scienze della Salute, Pneumologia riabilitativa, Fondazione Salvatore Maugeri Istituto Scientifico di Milano IRCCS, Via Camaldoli 64, Milano, Italy
    Pharmacol Res 66:343-8. 2012
    ..In conclusion, tiotropium showed a better antiinflammatory activity profile when compared to formoterol in a clinical setting, reducing superoxide and LTB₄ production by peripheral neutrophils obtained from COPD subjects...
  39. ncbi Chlamydia pneumoniae and acute aortic syndrome: a call for a multi-institutional study
    Eduardo Bossone
    Institute of Respiratory Disease, University of Milan, IRCCS Fondazione Policlinico Mangiagalli Regina Elena, Milano, Italy
    Monaldi Arch Chest Dis 70:68-70. 2008
    ..pneumoniae and acute aortic dissection. Well-designed large prospective studies are needed in order to clarify the pathophysiologic role of CP infection in acute and chronic aortic disease...
  40. ncbi MAPK and JNK transduction pathways can phosphorylate Sp1 to activate the uPA minimal promoter element and endogenous gene transcription
    Elisa Benasciutti
    Laboratory of Molecular Genetics, S Raffaele Scientific Institute and Università Vita Salute, Milan, Italy
    Blood 104:256-62. 2004
    ..The results suggest that the stress-activated protein kinase (SAPK)/JNK pathway plays an important role in the phosphorylation of Sp1, which, in turn, leads to basal or activated transcription from the uPA-MP element...
  41. doi Association between time to clinical stability and outcomes after discharge in hospitalized patients with community-acquired pneumonia
    Stefano Aliberti
    Dipartimento Toraco polmonare e Cardio circolatorio, University of Milan, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Milan, Italy
    Chest 140:482-8. 2011
    ..The objective of this study was to assess the association between TCS and outcomes after discharge in hospitalized patients with CAP...
  42. doi Antibiotics as immunomodulant agents in COPD
    Francesco Blasi
    Respiratory Medicine Section, Dipartimento Toraco Polmonare e Cardiocircolatorio, University of Milan, IRCCS Fondazione Cà Granda Ospedale Maggiore, Milan, Italy
    Curr Opin Pharmacol 12:293-9. 2012
    ..New macrolide derivatives devoid of antibacterial activity have been synthetized. This review analyses the relevance of immunomodulatory and anti-inflammatory effects of antibiotics in the management of COPD...
  43. pmc Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition
    Vittoria Matafora
    Division of Genomics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy
    Mol Cell Proteomics 8:2243-55. 2009
    ..The analysis of the nature of the SUMO-1 targets identified in this study strongly indicates that sumoylation, acting in coordination with the ubiquitin-proteasome system, regulates the maintenance of nucleolar integrity...
  44. doi Bronchiectasis: an update
    Maria Pappalettera
    Dipartimento Toraco Polmonare e Cardiovascolare, University of Milan, Istituti di Ricovero e Cura a Carattere Scientifico Fondazione PoMaRe, Milan, Italy
    Clin Respir J 3:126-34. 2009
    ..Bronchiectasis is defined as an abnormal and irreversible dilatation of the bronchi, often associated with chronic productive cough, airway obstruction, and recurrent infections...
  45. pmc Characterization of the regulatory region of the zebrafish Prep1.1 gene: analogies to the promoter of the human PREP1
    Elisa Bernardi
    IFOM FIRC Institute of Molecular Oncology Foundation, Milan, Italy
    PLoS ONE 5:e15047. 2010
    ..Moreover, about 40% of the sequences spread throughout the 5 Kbof the zebrafish promoter are concentrated in the -3 to -5 Kb of the human upstream region...
  46. ncbi The urokinase plasminogen activator system in cancer: recent advances and implication for prognosis and therapy
    Nicolai Sidenius
    Department of Molecular Biology and Functional Genomics, DIBIT, Universita Vita Salute San Raffaele, Via Olgettina 58, 20132 Milan, Italy
    Cancer Metastasis Rev 22:205-22. 2003
    ..This review is focused on recent insight into the cancer related biology of the uPA/uPAR system as well as its implications for clinical cancer diagnosis, prognosis and therapy...
  47. ncbi Urokinase plasminogen activator receptor affects bone homeostasis by regulating osteoblast and osteoclast function
    Federico Furlan
    H San Raffaele Scientific Institute and Università Vita Salute San Raffaele, Department of Molecular Biology and Functional Genomics, Milan, Italy
    J Bone Miner Res 22:1387-96. 2007
    ..We report that uPAR-lacking mice display increased BMD, increased osteogenic potential of osteoblasts, decreased osteoclasts formation, and altered cytoskeletal reorganization in mature osteoclasts...
  48. ncbi The urokinase receptor as an entertainer of signal transduction
    Silvia D'Alessio
    Department of Molecular Biology and Functional Genomics, DIBIT, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Front Biosci (Landmark Ed) 14:4575-87. 2009
    ..This review is focused on the biochemistry of the pathways affected by uPAR and its partners...
  49. ncbi Chlamydia pneumoniae and Mycoplasma pneumoniae
    Francesco Blasi
    Institute of Respiratory Diseases, University of Milan, IRCCS Fondazione Ospedale Maggiore Milano, Milan, Italy
    Semin Respir Crit Care Med 26:617-24. 2005
    ..pneumoniae infection. New macrolides, ketolides, and new fluoroquinolones are other potentially effective drugs...
  50. ncbi A review of guidelines for antibacterial use in acute exacerbations of chronic bronchitis
    Francesco Blasi
    Pad LITTA, IRCCS Ospedale Maggiore Policlinico, Via F Sforza, 35, 20122, University of Milan, Policlinico, Milan, Italy
    Pulm Pharmacol Ther 19:361-9. 2006
    ....
  51. pmc Dimerization controls the lipid raft partitioning of uPAR/CD87 and regulates its biological functions
    Orla Cunningham
    Molecular Genetics Unit, Department of Molecular Biology and Functional Genomics, Universita Vita Salute San Raffaele, Via Olgettina 58, 20132 Milan, Italy
    EMBO J 22:5994-6003. 2003
    ..In contrast to uPA, the binding of Vn occurred preferentially to raft- associated dimeric uPAR and was completely blocked by cholesterol depletion...
  52. ncbi uPAR: a versatile signalling orchestrator
    Francesco Blasi
    Department of Molecular Biology and Functional Genomics, DIBIT, Universita Vita Salute San Raffaele, Via Olgettina 58, 20132 Milano, Italy
    Nat Rev Mol Cell Biol 3:932-43. 2002
    ....
  53. ncbi The deficiency of tumor suppressor prep1 accelerates the onset of meis1- hoxa9 leukemogenesis
    Leila Dardaei
    Fondazione Istituto FIRC di Oncologia Molecolare IFOM, Milan, Italy
    PLoS ONE 9:e96711. 2014
    ..Finally, an important feature contributed by the Prep1i/i background is the post-transcriptional increase in Meis1 protein level. ..
  54. ncbi The role of antibiotics in asthma
    Francesco Blasi
    Institute of Respiratory Diseases, University of Milan, IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Int J Antimicrob Agents 29:485-93. 2007
    ..The ketolide antibiotics may also have similar properties. This paper discusses the role of these antibiotics in the management of asthma...
  55. ncbi Role of atypical bacteria and azithromycin therapy for children with recurrent respiratory tract infections
    Susanna Esposito
    Institute of Pediatrics, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, University of Milan, Milan, Italy
    Pediatr Infect Dis J 24:438-44. 2005
    ....
  56. pmc Cefditoren versus levofloxacin in patients with exacerbations of chronic bronchitis: serum inflammatory biomarkers, clinical efficacy, and microbiological eradication
    Francesco Blasi
    Department of Pathophysiology and Transplantation, University of Milan, IRCCS Fondazione Cà Granda Ospedale Maggiore Policlinico, Milan, Italy
    Ther Clin Risk Manag 9:55-64. 2013
    ....
  57. ncbi Phenotyping community-acquired pneumonia according to the presence of acute respiratory failure and severe sepsis
    Stefano Aliberti
    Department of Pathophysiology and Transplantation, IRCCS Fondazione Cà Granda Ospedale Maggiore Policlinico, University of Milan, Via F, Sforza 35, Milan, Italy
    Respir Res 15:27. 2014
    ..The aim of the study was to evaluate prevalence, characteristics, risk factors and impact on mortality of hospitalized patients with CAP according to the presence of ARF and SS on admission...
  58. ncbi uPA and uPAR in fibrinolysis, immunity and pathology
    Anna Mondino
    Department of Immunology and Infectious Diseases, Cancer Immunotherapy and Gene Therapy Program, San Raffaele Scientific Institute, DIBIT, Via Olgettina 58, 20132 Milan, Italy
    Trends Immunol 25:450-5. 2004
  59. ncbi The clinical and economic impact of exacerbations of chronic obstructive pulmonary disease: a cohort of hospitalized patients
    Francesco Blasi
    Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, IRCCS Fondazione Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy
    PLoS ONE 9:e101228. 2014
    ..This study assesses the burden of COPD in the general population, and the influence of exacerbations (E-COPD) on disease progression and costs...
  60. ncbi Newer antibiotics for the treatment of respiratory tract infections
    Francesco Blasi
    Institute of Respiratory Diseases, University of Milan, IRCCS Ospedale Maggiore di Milano, Milan, Italy
    Curr Opin Pulm Med 10:189-96. 2004
    ..In this review, we highlight some of the developments achieved over the past 2 years in the field of novel antimicrobial compounds...
  61. ncbi Strategic targets of essential host-pathogen interactions
    Francesco Blasi
    Institute of Respiratory Diseases, University of Milan, IRCCS Ospedale Maggiore Milano, Milano, Italy
    Respiration 72:9-25. 2005
    ....
  62. ncbi [Therapeutic experience with levofloxacin in pneumonia and COPD]
    Francesco Blasi
    Dipartimento Toraco Polmonare e Cardiovascolare, Universita degli Studi di Milano, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, IRCCS, Milano, Italy
    Infez Med 17:23-8. 2009
    ..pneumonaie e P. aeruginosa, that might emerge towards this antimicrobial class, although, to date, levofloxacin appears to be only marginally affected, in terms of resistance rates and of clinical significance...
  63. ncbi Anxiety and depression in COPD patients: The roles of gender and disease severity
    Fabiano Di Marco
    Respiratory Medicine Unit, University of Milan, Ospedale San Paolo, Milano, Italy
    Respir Med 100:1767-74. 2006
    ....
  64. doi Incidence, etiology, timing, and risk factors for clinical failure in hospitalized patients with community-acquired pneumonia
    Stefano Aliberti
    Institute of Respiratory Diseases, University of Milan, Milan, Italy
    Chest 134:955-62. 2008
    ..The objective of this study was to define the incidence, etiology, timing, and risk factors associated with clinical failures related to CAP vs those unrelated to CAP...
  65. ncbi Urokinase regulates vitronectin binding by controlling urokinase receptor oligomerization
    Nicolai Sidenius
    Molecular Genetics Unit, DIBIT, Universita Vita Salute San Raffaele, 20132 Milan, Italy
    J Biol Chem 277:27982-90. 2002
    ....