Francesco Dituri

Summary

Country: Italy

Publications

  1. pmc PI3K functions in cancer progression, anticancer immunity and immune evasion by tumors
    Francesco Dituri
    Department of Emergency and Organ Transplantation, Section of Internal Medicine, Allergology and Clinical Immunology, University of Bari Medical School, 70124 Bari, Italy
    Clin Dev Immunol 2011:947858. 2011
  2. doi request reprint Tumor-secreted lysophostatidic acid accelerates hepatocellular carcinoma progression by promoting differentiation of peritumoral fibroblasts in myofibroblasts
    Antonio Mazzocca
    Department of Internal Medicine, Immunology, and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    Hepatology 54:920-30. 2011
  3. doi request reprint PI3K class IB controls the cell cycle checkpoint promoting cell proliferation in hepatocellular carcinoma
    Francesco Dituri
    Department of Internal Medicine, Immunology and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    Int J Cancer 130:2505-13. 2012
  4. doi request reprint Hepatic stellate cells stimulate HCC cell migration via laminin-5 production
    Angela Santamato
    Department of Internal Medicine, Immunology and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    Clin Sci (Lond) 121:159-68. 2011
  5. doi request reprint Down-regulation of connective tissue growth factor by inhibition of transforming growth factor beta blocks the tumor-stroma cross-talk and tumor progression in hepatocellular carcinoma
    Antonio Mazzocca
    Department of Internal Medicine, Section of Internal Medicine, Policlinico, Bari, Italy
    Hepatology 51:523-34. 2010
  6. doi request reprint Moving towards personalised therapy in patients with hepatocellular carcinoma: the role of the microenvironment
    Gianluigi Giannelli
    Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari, Italy
    Gut 63:1668-76. 2014
  7. doi request reprint Circulating TGF-β1-related biomarkers in patients with hepatocellular carcinoma and their association with HCC staging scores
    Francesco Dituri
    Department of Biomedical Science and Human Oncology, Piazza G Cesare 11, 70124 Bari, Italy
    Cancer Lett 353:264-71. 2014

Collaborators

Detail Information

Publications7

  1. pmc PI3K functions in cancer progression, anticancer immunity and immune evasion by tumors
    Francesco Dituri
    Department of Emergency and Organ Transplantation, Section of Internal Medicine, Allergology and Clinical Immunology, University of Bari Medical School, 70124 Bari, Italy
    Clin Dev Immunol 2011:947858. 2011
    ..In addition, we discuss, from antitumor immunological point of view, the potential benefits and disadvantages arising from use of anticancer pharmacological agents targeting the PI3K pathway...
  2. doi request reprint Tumor-secreted lysophostatidic acid accelerates hepatocellular carcinoma progression by promoting differentiation of peritumoral fibroblasts in myofibroblasts
    Antonio Mazzocca
    Department of Internal Medicine, Immunology, and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    Hepatology 54:920-30. 2011
    ..Analysis of microdissected tissues indicated that stroma is the main target of the LPA paracrine loop in HCC. As a consequence, α-SMA-positive cells were more widespread in tumoral compared with paired peritumoral stroma...
  3. doi request reprint PI3K class IB controls the cell cycle checkpoint promoting cell proliferation in hepatocellular carcinoma
    Francesco Dituri
    Department of Internal Medicine, Immunology and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    Int J Cancer 130:2505-13. 2012
    ..Our results emphasize the role of p110γ as a promoter of HCC proliferation and unveil an important cell cycle regulation function of this molecule...
  4. doi request reprint Hepatic stellate cells stimulate HCC cell migration via laminin-5 production
    Angela Santamato
    Department of Internal Medicine, Immunology and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    Clin Sci (Lond) 121:159-68. 2011
    ..In human HCC tissues, Ln-5 is mainly distributed along α-SMA (smooth muscle actin)-positive cells, whereas in peritumoural tissues, Ln-5 is absent. HSCs stimulate HCC migration via the production and secretion of Ln-5...
  5. doi request reprint Down-regulation of connective tissue growth factor by inhibition of transforming growth factor beta blocks the tumor-stroma cross-talk and tumor progression in hepatocellular carcinoma
    Antonio Mazzocca
    Department of Internal Medicine, Section of Internal Medicine, Policlinico, Bari, Italy
    Hepatology 51:523-34. 2010
    ..Interestingly, patients with high CTGF expression had poor prognosis, suggesting that treatment aimed at reducing TGF-beta-dependent CTGF expression may offer clinical benefits...
  6. doi request reprint Moving towards personalised therapy in patients with hepatocellular carcinoma: the role of the microenvironment
    Gianluigi Giannelli
    Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari, Italy
    Gut 63:1668-76. 2014
    ..The development of biomarkers will be discussed in the light of new experimental research conducted with the aim of moving towards personalised therapy in patients with HCC. ..
  7. doi request reprint Circulating TGF-β1-related biomarkers in patients with hepatocellular carcinoma and their association with HCC staging scores
    Francesco Dituri
    Department of Biomedical Science and Human Oncology, Piazza G Cesare 11, 70124 Bari, Italy
    Cancer Lett 353:264-71. 2014
    ..In conclusion, TGF-β and E-cadherin are inversely correlated in HCC patients' sera and not related to the BCLC classification nor survival but rather to the biological properties of the tumor. ..