Research Topics
Species | Vito Di MarcoSummaryCountry: Italy Publications
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Publications
HBV-DNA suppression and disease course in HBV cirrhosis patients on long-term lamivudine therapyVito Di Marco
Cattedra e Unità Operativa Complessa di Gastroenterologia ed Epatologia, University of Palermo, Palermo, Italy
Antivir Ther 10:431-9. 2005..Profound and maintained HBV-DNA suppression correlates with a better outcome. Early identification of LAM resistance mutations allows switching to other antivirals before liver decompensation or hepatocellular carcinoma development...- Virological profiles in patients with chronic hepatitis C and overt or occult HBV infectionGiovanni Squadrito
Dipartimento di Medicina Interna, , Italy
Am J Gastroenterol 97:1518-23. 2002..CONCLUSION: A wide spectrum of HCV and HBV virological patterns may occur in a case of coinfection. HCV core variability is not related to HBV activity "in vivo.".. - HCV clearance among hemophiliacs and beta-thalassemicsVito Di Marco
Gastroenterology 132:1634. 2007 
IL28B polymorphisms influence stage of fibrosis and spontaneous or interferon-induced viral clearance in thalassemia patients with hepatitis C virus infectionVito Di Marco
Sezione di Gastroenterologia ed Epatologia, DiBiMIS, University of Palermo, Piazza delle Cliniche 2, 90127 Palermo, Italy
Haematologica 97:679-86. 2012..Polymorphisms in the interleukin-28B are important determinants in the spontaneous and drug-induced control of hepatitis C virus infection...- High-dose prolonged combination therapy in non-responders to interferon monotherapy for chronic hepatitis CV Di Marco
Cattedra e Divisione di Gastroenterologia, University of Palermo, Italy
Aliment Pharmacol Ther 15:953-8. 2001..Therapy of chronic hepatitis C non- responders to interferon monotherapy with standard doses of interferon plus ribavirin is usually ineffective... - Peg-interferon alone or combined with ribavirin in HCV cirrhosis with portal hypertension: a randomized controlled trialVito Di Marco
Cattedra di Gastroenterologia and Unità Operativa Complessa di Gastroenterologia ed Epatologia, Di Bi M I S, Piazza delle Cliniche 2, 90127 Palermo, Italy
J Hepatol 47:484-91. 2007..Risks and benefits of antiviral therapy in HCV cirrhosis with portal hypertension are poorly known... - Clinical outcome of HBeAg-negative chronic hepatitis B in relation to virological response to lamivudineVito Di Marco
Cattedra e U O C di Gastroenterologia, Clinica Medica, Universita di Palermo, Palermo, Italy
Hepatology 40:883-91. 2004..After 4 years of therapy, 39% of patients maintain a virological and biochemical response. Loss of virological response may lead to clinical deterioration in patients with cirrhosis... 
Chronic hepatitis B: who to treat and which choice of treatment?Vito Di Marco
Dipartimento Biomedico di Medicina Interna e Specialistica, Gastroenterology and Hepatology Unit, University of Palermo, Palermo, Italy
Expert Rev Anti Infect Ther 7:281-91. 2009..Patients with compensated or decompensated cirrhosis should be treated, even if alanine aminotransferase levels are normal and/or serum HBV DNA levels are low, in order to prevent disease flare and to improve liver function...- Liver disease in chelated transfusion-dependent thalassemics: the role of iron overload and chronic hepatitis CVito Di Marco
Dipartimento Biomedico di Medicina Interna e Specialistica, DiBiMIS, University of Palermo, Piazza delle Cliniche 2, 90127 Palermo, Italy
Haematologica 93:1243-6. 2008..Adequate chelation therapy usually prevents the development of liver fibrosis in thalassemics free of hepatitis virus C-infection and reduces the risk of developing severe fibrosis in thalassemics with chronic hepatitis C... - Early viral clearance and sustained response in chronic hepatitis C: a controlled trial of interferon and ribavirin after high-dose interferon inductionV Di Marco
Cattedra di Gastroenterologia, Clinica Medica, University of Palermo, Palermo, Italy
J Viral Hepat 9:354-9. 2002..The rate of sustained response is a function of the time to HCV-RNA clearance. In patients not responding to induction therapy addition of ribavirin does not obtain a sustained virological response... - Management of chronic viral hepatitis in patients with thalassemia: recommendations from an international panelVito Di Marco
Italian Society for the Study of Thalassemia and Haemoglobinopathies, Rome, Italy
Blood 116:2875-83. 2010.... - Noninvasive assessment of liver fibrosis in thalassaemia major patients by transient elastography (TE) - lack of interference by iron depositionVito Di Marco
Dipartimento Biomedico di Medicina Interna e Specialistica Di Bi M I S, Unità Complessa di Gastroenterologia ed Epatologia, University of Palermo, Palermo, Italy
Br J Haematol 148:476-9. 2010..0-100.0) and 95% specificity (95% CI: 84.2-99.3). Transient elastography is a reliable non-invasive tool for diagnosing advanced liver fibrosis in homozygous-beta-thalassaemics, regardless of the degree of iron overload... - Insulin resistance and diabetes increase fibrosis in the liver of patients with genotype 1 HCV infectionSalvatore Petta
Cattedra ed Unità Operativa di Gastroenterologia, University of Palermo, Palermo, Italy
Am J Gastroenterol 103:1136-44. 2008..We aimed to assess whether increasing degrees of IR, up to overt diabetes, are linked to steatosis and higher stages of fibrosis in patients with CHC resulting from genotype 1 HCV (G1-HCV)... - Time course of insulin resistance during antiviral therapy in non-diabetic, non-cirrhotic patients with genotype 1 HCV infectionSalvatore Petta
Cattedra ed Unità Operativa di Gastroenterologia, Universita di Palermo, Palermo, Italy
Antivir Ther 14:631-9. 2009..We aimed to evaluate the time course of IR in response to antiviral therapy in non-diabetic, non-cirrhotic G1 HCV patients and to assess the effect of metabolic factors on sustained virological response (SVR)... - Vitamin D levels and IL28B polymorphisms are related to rapid virological response to standard of care in genotype 1 chronic hepatitis CSalvatore Petta
Sezione di Gastroenterologia, DiBiMIS, University of Palermo, Palermo, Italy
Antivir Ther 17:823-31. 2012..We assessed whether 25-hydroxyvitamin D (25[OH]D) serum levels are linked to RVR and can be used together with IL28B to construct a pretreatment model to predict RVR... - Visceral adiposity index is associated with histological findings and high viral load in patients with chronic hepatitis C due to genotype 1Salvatore Petta
Dipartimento Biomedico di Medicina Interna e Specialistica, Cattedra di Gastroenterologia, DiBiMIS, Palermo, Italy
Hepatology 52:1543-52. 2010..CONCLUSION: In G1 CHC patients, higher VAI score is independently associated with both steatosis and necroinflammatory activity and has a direct correlation with viral load... - Hepatic steatosis and insulin resistance are associated with severe fibrosis in patients with chronic hepatitis caused by HBV or HCV infectionSalvatore Petta
Sezione di Gastroenterologia, University of Palermo, Palermo, Italy
Liver Int 31:507-15. 2011..We aimed to assess the prevalence and the factors related to steatosis and IR in CHB patients, compared with CHC subjects, and to evaluate the potential association between these features and fibrosis severity... - HVR-1 quasispecies modifications occur early and are correlated to initial but not sustained response in HCV-infected patients treated with pegylated- or standard-interferon and ribavirinIsabella Abbate
Department of Virology, National Institute for Infectious Diseases L. Spallanzani, Rome, Italy
J Hepatol 40:831-6. 2004..Viral quasispecies surviving early therapeutic pressure are most likely able to give rise to either virus rebound or persistence at T18... - Different doses of consensus interferon plus ribavirin in patients with hepatitis C virus genotype 1 relapsed after interferon monotherapy: a randomized controlled trialGiuseppe Alaimo
Cattedra di Gastroenterologia, University of Palermo, Piazza delle Cliniche 2, Palermo 90127, Italy
World J Gastroenterol 12:6861-4. 2006..This may be due to its scarce tolerability... - IL28B and PNPLA3 polymorphisms affect histological liver damage in patients with non-alcoholic fatty liver diseaseSalvatore Petta
Sezione di Gastroenterologia, DiBiMIS, University of Palermo, Italy
J Hepatol 56:1356-62. 2012..The main outcomes of the study were to assess whether IL28B rs12979860 and rs8099917 polymorphisms, together with PNPLA3 rs738409 C>G polymorphism, are associated with lobular inflammation and fibrosis, in NAFLD patients... - Carotid atherosclerosis and chronic hepatitis C: a prospective study of risk associationsSalvatore Petta
Sezione di Gastroenterologia, Di Bi M I S, Universita di Palermo, Italia
Hepatology 55:1317-23. 2012..1% versus 22/43, 51.1%; P = 0.51). CONCLUSION: Severe hepatic fibrosis is associated with a high risk of early carotid atherosclerosis in G1 CHC patients... - Insulin resistance is associated with steatosis in nondiabetic patients with genotype 1 chronic hepatitis CCalogero Cammà
Unità Operativa di Gastroenterologia, University of Palermo, Italy
Hepatology 43:64-71. 2006..IR is a risk factor for moderate/severe steatosis, especially in men. Moderate/severe steatosis has clinical relevance, being associated with advanced fibrosis and hyporesponsiveness to antiviral therapy... - Intrahepatic IgG/IgM plasma cells ratio helps in classifying autoimmune liver diseasesDaniela Cabibi
Dipartimento di Patologia Umana, University of Palermo, Italy
Dig Liver Dis 42:585-92. 2010.... - Insulin resistance is a risk factor for esophageal varices in hepatitis C virus cirrhosisCalogero Cammà
Cattedra and Unità Operativa di Gastroenterologia, Di Bi M I S, University of Palermo, Italy
Hepatology 49:195-203. 2009.... - Low vitamin D serum level is related to severe fibrosis and low responsiveness to interferon-based therapy in genotype 1 chronic hepatitis CSalvatore Petta
Cattedra ed Unità Operativa di Gastroenterologia, DiBiMIS, University of Palermo, Italy
Hepatology 51:1158-67. 2010..Conclusion: G1 CHC patients had low 25(OH)D serum levels, possibly because of reduced CYP27A1 expression. Low vitamin D is linked to severe fibrosis and low SVR on interferon (IFN)-based therapy... - High liver RBP4 protein content is associated with histological features in patients with genotype 1 chronic hepatitis C and with nonalcoholic steatohepatitisSalvatore Petta
Sezione di Gastroenterologia, DiBiMIS, University of Palermo, Italy
Dig Liver Dis 43:404-10. 2011..To investigate the hepatic expression of retinol-binding protein-4 (RBP4) in chronic hepatitis C (CHC) and nonalcoholic steatohepatitis (NASH) patients, and its association with biochemical and histological patterns of liver damage... - Retinol-binding protein 4: a new marker of virus-induced steatosis in patients infected with hepatitis c virus genotype 1Salvatore Petta
Cattedra ed Unità Operativa di Gastroenterologia, University of Palermo, Palermo, Italy
Hepatology 48:28-37. 2008..095; 95% confidence interval, 1.007 to 1.192; P = 0.03). CONCLUSION: In nondiabetic, nonobese patients with genotype 1 CHC, serum RBP4 levels might be the expression of a virus-linked pathway to steatosis, largely unrelated to IR... - Evaluating the risk of hepatitis B reactivation in patients with haematological malignancies: is the serum hepatitis B virus profile reliable?Donatella Ferraro
Cattedra di Virologia, Dipartimento di Scienze per la Promozione della Salute G D Alessandro, University of Palermo, Sicily, Italy
Liver Int 29:1171-7. 2009.... - Endogenous levels of mRNA for IFNs and IFN-related genes in hepatic biopsies of chronic HCV-infected and non-alcoholic steatohepatitis patientsIsabella Abbate
Microbiology and Virology Service, S. Pertini Hospital, Rome, Italy
J Med Virol 70:581-7. 2003.... - ISDR pattern and evolution in patients with chronic hepatitis C treated with standard or PEG-IFN plus ribavirinGiuseppina Cappiello
National Institute for Infectious Diseases L Spallanzani, Rome, Italy
Antivir Ther 8:105-10. 2003..Thus, in our patients the baseline pattern of ISDR was unrelated to treatment outcome. Selection towards a dominant IFN-resistant strain did not occur under standard or PEG-IFN plus RBV... - Changing aetiological factors of hepatocellular carcinoma and their potential impact on the effectiveness of surveillanceTommaso Stroffolini
Dipartimento Malattie Infettive e Tropicali, Policlinico Umberto I, Rome, Italy
Dig Liver Dis 43:875-80. 2011..The aetiological factors of hepatocellular carcinoma may vary over time... - Anti-tissue transglutaminase antibodies in patients with abnormal liver tests: is it always coeliac disease?Oreste Lo Iacono
University of Palermo, Gastroenterology and Hepatology Unit, Palermo, Italy
Am J Gastroenterol 100:2472-7. 2005..In this population the efficacy of screening for CD by anti-tissue transglutaminase (anti-tTG) may be impaired by the high rate of positive anti-tTG found in chronic liver disease... - Hyperferritinemia is a risk factor for steatosis in chronic liver diseaseAnna Licata
Gastroenterology and Hepatology Unit, Department of Internal Medicine, University of Palermo, 90127 Palermo, Italy
World J Gastroenterol 15:2132-8. 2009..To investigate the relationship between ferritin and steatosis in patients with chronically abnormal liver function tests (LFTs) and high ferritin level... - Peginterferon alfa-2b plus ribavirin for naïve patients with genotype 1 chronic hepatitis C: a randomized controlled trialSavino Bruno
Clinica Medica, Ospedale San Paolo and Liver Unit, Ospedale Fatebenefratelli e Oftalmico, Milano, Italy
J Hepatol 41:474-81. 2004..In patients aged less than 50 years with mild fibrosis this schedule achieves a very high rate of SVR... - Serum γ-glutamyl transferase levels, insulin resistance and liver fibrosis in patients with chronic liver diseasesSalvatore Petta
Sezione di Gastroenterologia, DiBiMIS, University of Palermo, Palermo, Italy
PLoS ONE 7:e51165. 2012.... - Natural history of untreatable hepatocellular carcinoma: A retrospective cohort studyGiuseppe Cabibbo
Giuseppe Cabibbo, Marcello Maida, Chiara Genco, Pietro Parisi, Marco Peralta, Michela Antonucci, Giuseppe Brancatelli, Calogero Cammà, Antonio Craxì, Vito Di Marco, Section of Gastroenterology, Department of Internal Medicine and Biomedical Specialist, University of Palermo, Palermo 90127, Italy
World J Hepatol 4:256-61. 2012..To investigate the clinical course of untreatable hepatocellular carcinoma (HCC) identified at any stage and to identify factors associated with mortality... - Cost-effectiveness of boceprevir or telaprevir for untreated patients with genotype 1 chronic hepatitis CCalogero Cammà
Sezione di Gastroenterologia, Di Bi M I S, University of Palermo, Italy
Hepatology 56:850-60. 2012..Multiple strategies to reduce costs and improve effectiveness include RVR or genotype-guided treatment... - Evolving clinical landscape of chronic hepatitis B: A multicenter Italian studyTommaso Stroffolini
Department of Infectious and Tropical Diseases, University La Sapienza, Rome, Italy
J Med Virol 81:1999-2006. 2009.... - Treatment of hepatocellular carcinoma in compensated cirrhosis with radio-frequency thermal ablation (RFTA): a prospective studyCalogero Cammà
Cattedra e Unità Operativa di Gastroenterologia, University of Palermo, Palermo, Italy
J Hepatol 42:535-40. 2005..To assess the effectiveness and the safety of radio-frequency thermal ablation (RFTA) in patients with hepatocellular carcinoma (HCC) < or = 5 cm in compensated cirrhosis... - Halitosis: could it be more than mere bad breath?Giuseppina Campisi
Sector of Oral Medicine, Department of Oral Sciences, University of Palermo, Via del Vespro 129, 90127, Palermo, Italy
Intern Emerg Med 6:315-9. 2011..Extra-oral disorders can be the cause in up to 15% of cases... - Congenital hepatic fibrosis: a very uncommon cause of pancytopenia in childrenAntonino Trizzino
Onco Ematologia Pediatrica, Ospedale dei Bambini G Di Cristina, Palermo, Italy
J Pediatr Hematol Oncol 27:567-8. 2005..The authors report an unusual case of ARPKD presenting with hepatosplenomegaly and cytopenia mimicking acute leukemia... - Combination therapy with amantadine and interferon in naïve patients with chronic hepatitis C: meta-analysis of individual patient data from six clinical trialsAlessandra Mangia
Division of Gastroenterology, Ospedale Casa Sollievo Sofferenza, IRCCS, San Giovanni Rotondo 71013, Italy
J Hepatol 40:478-83. 2004..CONCLUSIONS: In chronic hepatitis C, therapy with AMA and INF is effective and may be an alternative to INF and ribavirin in patients who cannot tolerate ribavirin... - Adefovir for lamivudine resistant HBV: more than meets the eyeVito Di Marco
J Hepatol 47:618-9; author reply 619-20. 2007 - [Radiofrequency thermoablation in the treatment of primary and secondary liver tumours]Luigi Sandonato
, la Diagnosi ed il Trattamento delle Neoplasie Epatiche,
Chir Ital 56:117-26. 2004.... - [Iron overload disease: recent findings]Anna Licata
Istituto di Clinica Medica I, Universita degli Studi di Palermo
Ann Ital Med Int 19:145-54. 2004....