Mario Di Napoli

Summary

Country: Italy

Publications

  1. pmc Neuroinflammation and cerebrovascular disease in old age: a translational medicine perspective
    Mario Di Napoli
    Neurological Service, San Camillo de Lellis General Hospital, 02100 Rieti, Italy
    J Aging Res 2011:857484. 2011
  2. doi request reprint C-reactive protein in intracerebral hemorrhage: time course, tissue localization, and prognosis
    Mario Di Napoli
    Neurological Service, San Camillo de Lellis General Hospital, Rieti, Italy
    Neurology 79:690-9. 2012
  3. ncbi request reprint Prognostic influence of increased C-reactive protein and fibrinogen levels in ischemic stroke
    M Di Napoli
    Department of Neurology and Neurorehabilitation, Villa Pini d Abruzzo Care Center, Chieti, Italy
    Stroke 32:133-8. 2001
  4. ncbi request reprint Inflammation, blood pressure, and stroke: an opportunity to target primary prevention?
    Mario Di Napoli
    SMDN Center for Cardiovascular Medicine and Cerebrovascular Disease Prevention, Neurological Section, Via Trento, 41, I 67039 Sulmona AQ Italy
    Curr Hypertens Rep 7:44-51. 2005
  5. ncbi request reprint Clinical application of C-reactive protein in stroke prevention: bright and dark sides of the moon
    Mario Di Napoli
    SMDN Center for Cardiovascular Medicine and Cerebrovascular Disease Prevention, Via Trento, 41, 67039 Sulmona AQ, Italy
    Expert Rev Neurother 4:613-22. 2004
  6. ncbi request reprint Evaluation of C-reactive protein measurement for assessing the risk and prognosis in ischemic stroke: a statement for health care professionals from the CRP Pooling Project members
    Mario Di Napoli
    San Camillo de Lellis General Hospital, Rieti, Italy
    Stroke 36:1316-29. 2005
  7. pmc The ubiquitin-proteasome system as a drug target in cerebrovascular disease: therapeutic potential of proteasome inhibitors
    Mario Di Napoli
    Neurological Section, SMDN Center for Cardiovascular Medicine and Cerebrovascular Disease Prevention, Via Trento, 41 67039 Sulmona AQ, Italy
    Curr Opin Investig Drugs 6:686-99. 2005
  8. ncbi request reprint Systemic inflammation, blood pressure, and stroke outcome
    Mario Di Napoli
    Neurological Service, San Camillo de Lellis General Hospital, Rieti, Italy
    J Clin Hypertens (Greenwich) 8:187-94. 2006
  9. ncbi request reprint [Present insights in the cerebral small vessel disease physiopathology: the role of C-reactive protein]
    Mario Di Napoli
    Servizio di Neurologia, Ospedale Generale Provinciale San Camillo de Lellis, Rieti
    Recenti Prog Med 97:246-56. 2006
  10. ncbi request reprint Molecular pathways and genetic aspects of Parkinson's disease: from bench to bedside
    Mario Di Napoli
    Neurological Service, San Camillo de Lellis General Hospital, I 2100 Rieti, Italy
    Expert Rev Neurother 7:1693-729. 2007

Detail Information

Publications35

  1. pmc Neuroinflammation and cerebrovascular disease in old age: a translational medicine perspective
    Mario Di Napoli
    Neurological Service, San Camillo de Lellis General Hospital, 02100 Rieti, Italy
    J Aging Res 2011:857484. 2011
    ..This paper will discuss these molecular aspects of acute stroke and senescence from a bench-to-bedside research perspective...
  2. doi request reprint C-reactive protein in intracerebral hemorrhage: time course, tissue localization, and prognosis
    Mario Di Napoli
    Neurological Service, San Camillo de Lellis General Hospital, Rieti, Italy
    Neurology 79:690-9. 2012
    ..We examined the C-reactive protein (CRP) response after spontaneous intracerebral hemorrhage (sICH) and its relationship to outcome. We additionally characterized early brain localization of CRP...
  3. ncbi request reprint Prognostic influence of increased C-reactive protein and fibrinogen levels in ischemic stroke
    M Di Napoli
    Department of Neurology and Neurorehabilitation, Villa Pini d Abruzzo Care Center, Chieti, Italy
    Stroke 32:133-8. 2001
    ..The aim of this study was to investigate and compare the 1-year prognostic influences of fibrinogen and CRP levels on outcome in ischemic stroke...
  4. ncbi request reprint Inflammation, blood pressure, and stroke: an opportunity to target primary prevention?
    Mario Di Napoli
    SMDN Center for Cardiovascular Medicine and Cerebrovascular Disease Prevention, Neurological Section, Via Trento, 41, I 67039 Sulmona AQ Italy
    Curr Hypertens Rep 7:44-51. 2005
    ..Whether these targets will be useful in the development of risk prediction strategies or therapies for the treatment of stroke in humans is far from clear...
  5. ncbi request reprint Clinical application of C-reactive protein in stroke prevention: bright and dark sides of the moon
    Mario Di Napoli
    SMDN Center for Cardiovascular Medicine and Cerebrovascular Disease Prevention, Via Trento, 41, 67039 Sulmona AQ, Italy
    Expert Rev Neurother 4:613-22. 2004
    ..High-sensitivity C-reactive protein assays as a screening test, only provide inadequate evidence to be considered as an effective cerebrovascular screening test, especially in the elderly...
  6. ncbi request reprint Evaluation of C-reactive protein measurement for assessing the risk and prognosis in ischemic stroke: a statement for health care professionals from the CRP Pooling Project members
    Mario Di Napoli
    San Camillo de Lellis General Hospital, Rieti, Italy
    Stroke 36:1316-29. 2005
    ..The aim of this review is to summarize the evidence for CRP as an independent predictor of cerebrovascular events in at-risk individuals and ischemic stroke patients and to consider its usefulness in evaluating prognosis after stroke...
  7. pmc The ubiquitin-proteasome system as a drug target in cerebrovascular disease: therapeutic potential of proteasome inhibitors
    Mario Di Napoli
    Neurological Section, SMDN Center for Cardiovascular Medicine and Cerebrovascular Disease Prevention, Via Trento, 41 67039 Sulmona AQ, Italy
    Curr Opin Investig Drugs 6:686-99. 2005
    ..Studies in animal models indicate that the use of specific proteasome inhibitors may be beneficial in treating a host of acute neurological disorders, including ischemic stroke...
  8. ncbi request reprint Systemic inflammation, blood pressure, and stroke outcome
    Mario Di Napoli
    Neurological Service, San Camillo de Lellis General Hospital, Rieti, Italy
    J Clin Hypertens (Greenwich) 8:187-94. 2006
    ..Whether this target will be useful in the development of risk prediction strategies or therapies for the treatment of stroke in humans is far from clear...
  9. ncbi request reprint [Present insights in the cerebral small vessel disease physiopathology: the role of C-reactive protein]
    Mario Di Napoli
    Servizio di Neurologia, Ospedale Generale Provinciale San Camillo de Lellis, Rieti
    Recenti Prog Med 97:246-56. 2006
    ..It may be that adding evaluation of inflammatory markers, such as C-reactive protein, to conventional risk factors will allow more appropriate preventive and therapeutic interventions...
  10. ncbi request reprint Molecular pathways and genetic aspects of Parkinson's disease: from bench to bedside
    Mario Di Napoli
    Neurological Service, San Camillo de Lellis General Hospital, I 2100 Rieti, Italy
    Expert Rev Neurother 7:1693-729. 2007
    ..This article reviews important molecular mechanisms and genetic causes implicated in the pathogenesis of PD, which has led to new areas of therapeutic drug research...
  11. ncbi request reprint New molecular avenues in Parkinson's disease therapy
    Mario Di Napoli
    Neurological Service, San Camillo de Lellis General Hospital, I0 2100 Rieti, Italy
    Curr Top Med Chem 9:913-48. 2009
    ..This review examines how these genetic findings provided us with suitable animal models and how the gained insights will contribute to better therapies for PD...
  12. doi request reprint C-reactive protein level measurement improves mortality prediction when added to the spontaneous intracerebral hemorrhage score
    Mario Di Napoli
    Neurological Service, San Camillo de Lellis General Hospital, Rieti, Italy
    Stroke 42:1230-6. 2011
    ..We sought to determine whether elevation of white blood cell count (WBC), C-reactive protein (CRP), and blood glucose (BG) concentration at presentation prognosticate poor outcome in sICH patients...
  13. doi request reprint Role of C-reactive protein in cerebrovascular disease: a critical review
    Mario Di Napoli
    Neurological Service, San Camillo de Lellis General Hospital, Rieti, Italy
    Expert Rev Cardiovasc Ther 9:1565-84. 2011
    ....
  14. ncbi request reprint M-40403 Metaphore Pharmaceuticals
    Mario Di Napoli
    Neurological Section, SMDN Center for Cardiovascular Medicine and Cerebrovascular Disease Prevention, Via Trento 41, I 67039 Sulmona AQ, Italy
    IDrugs 8:67-76. 2005
    ..The company is also investigating the compound for its potential in the treatment for the side effects associated with chemotherapy and radiation therapy...
  15. ncbi request reprint Inflammation, hemostatic markers, and antithrombotic agents in relation to long-term risk of new cardiovascular events in first-ever ischemic stroke patients
    Mario Di Napoli
    Department of Neurology and Neurorehabilitation, Casa di Cura Villa Pini d Abruzzo, Chieti, Italy
    Stroke 33:1763-71. 2002
    ..We evaluated the usefulness of these markers as predictors of cardiovascular events in ischemic stroke patients...
  16. ncbi request reprint Benefits of statins in cerebrovascular disease
    Mario Di Napoli
    Neurological Section, SMDN Center for Cardiovascular Medicine and Cerebrovascular, Disease Prevention, 41 Via Trento, I 67039 Sulmona, AQ, Italy
    Curr Opin Investig Drugs 5:295-305. 2004
    ..Statins offer potential benefits for reducing the incidence and improving the prognosis of stroke...
  17. ncbi request reprint The proteasome system and proteasome inhibitors in stroke: controlling the inflammatory response
    Mario Di Napoli
    Neurological Section, SMDN Center for Cardiovascular Medicine and Cerebrovascular, Disease Prevention, Via Trento 41, I 67039 Sulmona, L Aquila, Italy
    Curr Opin Investig Drugs 4:1333-42. 2003
    ..Promising results from preclinical studies in animal models indicate that the use of specific proteasome inhibitors to manipulate UPP may prove valuable in treating such conditions as ischemic stroke...
  18. ncbi request reprint C-reactive protein in ischemic stroke: an independent prognostic factor
    M Di Napoli
    Department of Neurology and Neurorehabilitation, Casa di Cura Villa Pini d Abruzzo, Chieti, Italy
    Stroke 32:917-24. 2001
    ..Therefore, we assessed the prognostic values of CRP in ischemic stroke. We also compared the relation of CRP at admission and discharge with 1-year outcome...
  19. ncbi request reprint Angiotensin-converting enzyme inhibitor use is associated with reduced plasma concentration of C-reactive protein in patients with first-ever ischemic stroke
    Mario Di Napoli
    Neurological Section, SMDN Center for Cardiovascular Medicine and Cerebrovascular Disease Prevention, Sulmona, L Aquila, Italy
    Stroke 34:2922-9. 2003
    ..Data evaluating this hypothesis are limited in ischemic stroke...
  20. ncbi request reprint Association between blood pressure and C-reactive protein levels in acute ischemic stroke
    Mario Di Napoli
    Neurological Section, SMDN Center for Cardiovascular Medicine and Cerebrovascular Disease Prevention, Via Trento, 41, 67039, Sulmona, L Aquila, Italy
    Hypertension 42:1117-23. 2003
    ..These findings support a possible role of acute hypertension after stroke as an inflammatory stimulus contributing to ischemic brain inflammation...
  21. ncbi request reprint MLN-519. Millennium/PAION
    Mario Di Napoli
    Neurological Section, SMDN Center for Cardiovascular Medicine, 41 Via Trento, I 67039 Sulmona, AQ, Italy
    Curr Opin Investig Drugs 4:333-41. 2003
    ..MLN-519 is currently undergoing phase I clinical trials in acute stroke and myocardial infarction, and is poised to enter phase II trials...
  22. ncbi request reprint NCX-4016 NicOx
    Mario Di Napoli
    Neurological Section, SMDN Center for Cardiovascular Medicine and Cerebrovascular Disease Prevention, 41 Via Trento, I 67039 Sulmona, AQ, Italy
    Curr Opin Investig Drugs 4:1126-39. 2003
    ....
  23. doi request reprint C-reactive protein predicts hematoma growth in intracerebral hemorrhage
    Mario Di Napoli
    From the Neurological Service, San Camillo de Lellis General Hospital, Rieti, Italy M D N Neurological Section, SMDN Center for Cardiovascular Medicine and Cerebrovascular Disease Prevention, Sulmona, L Aquila, Italy M D N, F P Vascular and Stroke Centre, Manchester Academic Health Science Centre, Salford Royal NHS Foundation Trust, Salford, United Kingdom A R P J, C J S, S J H SBCHS, Manchester Metropolitan University, Manchester, United Kingdom M S Institut Català de Ciències Cardiovasculars Hospital de la Santa Creu i Sant Pau, Pavelló del Convent Sant Antoni Maria Claret, Barcelona, Spain M S Department of Internal Medicine, Cecina Hospital, Cecina, Italy L M Central Laboratory, Sanatorio Pasteur, Catamarca, Argentina V C Molecular Genetics Laboratory, Department of Human Genetics, Punjabi University, Patiala, India P S Research Center for Microscopic Morphology and Immunology and Chair of Biochemistry, University of Medicine and Pharmacy of Craiova, Craiova, Romania A P W Molecular Psychiatry, Department of Psychiatry, Medical University Rostock, Philadelphia
    Stroke 45:59-65. 2014
    ..The main aim of this study was to investigate the potential of plasma C-reactive protein (CRP) for predicting EHG after acute spontaneous intracerebral hemorrhage...
  24. doi request reprint The practical management of intracerebral hemorrhage associated with oral anticoagulant therapy
    Luca Masotti
    Internal Medicine, Cecina Hospital, Cecina, Italy Neurological Service, San Camillo de Lellis General Hospital, Rieti, Italy
    Int J Stroke 6:228-40. 2011
    ..On the basis of the available knowledge, inappropriate adherence to current consensus-based guidelines for coagulopathy reversal may expose the physician to medico-legal implications...
  25. ncbi request reprint The ubiquitin-proteasome system and proteasome inhibitors in central nervous system diseases
    Imtiaz M Shah
    Neurological Section, SMDN Center for Cardiovascular Medicine and Cerebrovascular Disease Prevention, I 67039 Sulmona AQ, Italy
    Cardiovasc Hematol Disord Drug Targets 7:250-73. 2007
    ....
  26. ncbi request reprint Clinical use of C-reactive protein for prognostic stratification in ischemic stroke: has the time come for including it in the patient risk profile?
    Mario Di Napoli
    Stroke 34:375-6; author reply 375-6. 2003
  27. ncbi request reprint C-reactive protein and blood pressure in the acute phase after an ischemic stroke
    Mario Di Napoli
    Stroke 34:839. 2003
  28. ncbi request reprint Editorial comment--C-reactive protein and vascular risk in stroke patients: potential use for the future
    Mario Di Napoli
    Stroke 34:2468-70. 2003
  29. ncbi request reprint C-reactive protein and cerebral small-vessel disease: an opportunity to reassess small-vessel disease physiopathology?
    Mario Di Napoli
    Circulation 112:781-5. 2005
  30. ncbi request reprint Ubiquitin-proteasome system and proteasome inhibition: new strategies in stroke therapy
    Cezary Wojcik
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Stroke 35:1506-18. 2004
    ..There are now overwhelming data suggesting that the UPS contributes to cerebral ischemic injury...
  31. ncbi request reprint Editorial comment--How to search for the role of genetic polymorphisms in stroke: theory versus practice
    Mario Di Napoli
    Stroke 34:1869-70. 2003
  32. ncbi request reprint Clinical grading scales in spontaneous intracerebral hemorrhage
    Mario Di Napoli
    Stroke 38:e133-5; author reply e136. 2007
  33. ncbi request reprint Should neurologists measure fibrinogen concentrations?
    Mario Di Napoli
    J Neurol Sci 246:5-9. 2006
  34. ncbi request reprint Predicting mortality in spontaneous intracerebral hemorrhage: can modification to original score improve the prediction?
    Daniel Agustin Godoy
    Neurointensive Care Unit, Sanatorio Pasteur, Catamarca, Argentina
    Stroke 37:1038-44. 2006
    ....
  35. ncbi request reprint POEMS syndrome, fibrinogen, and ischemic stroke: a critical point of view
    Mario Di Napoli
    Arch Neurol 61:155; author reply 155-6. 2004