Research Topics
| Gaetano Di ChiaraSummaryCountry: Italy Publications
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Detail Information
Publications
Drug addiction as dopamine-dependent associative learning disorderG Di Chiara
Department of Toxicology and CNR Center for Neuropharmacology, University of Cagliari, Italy
Eur J Pharmacol 375:13-30. 1999....- Role of dopamine in the behavioural actions of nicotine related to addictionG Di Chiara
Department of Toxicology and CNR Center of Neuropharmacology, University of Cagliari, Viale Diaz 182, 09100 Cagliari, Italy
Eur J Pharmacol 393:295-314. 2000..Unavailability of tobacco disrupts the automatic, implicit modality of abnormal habit responding switching responding into the explicit, conscious modality of incentive drug-seeking and craving... - From rats to humans and return: testing addiction hypotheses by combined PET imaging and self-reported measures of psychostimulant effects. Commentary on Volkow et al. 'Role of dopamine in drug reinforcement and addiction in humans: results from imaging sG Di Chiara
Department of Toxicology, University of Cagliari, V.Ospedale 42, 09124 Cagliari, Italy
Behav Pharmacol 13:371-7. 2002 - Nucleus accumbens shell and core dopamine: differential role in behavior and addictionGaetano Di Chiara
Department of Toxicology, Center of Excellence for Studies on Dependence CESID and CNR Neuroscience Institute, University of Cagliari, Via Ospedale, 72 I 09124, Cagliari, Italy
Behav Brain Res 137:75-114. 2002.... - Differential neurochemical and behavioral adaptation to cocaine after response contingent and noncontingent exposure in the ratDaniele Lecca
Department of Toxicology, University of Cagliari, Via Ospedale 72, 09124, Cagliari, Italy
Psychopharmacology (Berl) 191:653-67. 2007..Repeated exposure to the same drugs results in behavioral and biochemical sensitization characterized by stereotyped activity and reduction of the shell/core DA response ratio... - Dopamine and drug addiction: the nucleus accumbens shell connectionGaetano Di Chiara
Department of Toxicology, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy
Neuropharmacology 47:227-41. 2004..It is speculated that drug addiction results from the impact exerted on behavior by the abnormal DA stimulant properties acquired by drug-conditioned stimuli as a result of their association with addictive drugs... - Differential impact of pavlovian drug conditioned stimuli on in vivo dopamine transmission in the rat accumbens shell and core and in the prefrontal cortexValentina Bassareo
Department of Toxicology and Center of Excellence for Studies on Dependence, University of Cagliari, Cagliari, Italy
Psychopharmacology (Berl) 191:689-703. 2007..Conditioned stimuli (CSs) by pavlovian association with reinforcing drugs (US) are thought to play an important role in the acquisition, maintenance and relapse of drug dependence... 
Nicotine differentially affects dopamine transmission in the nucleus accumbens shell and core of Lewis and Fischer 344 ratsCristina Cadoni
CNR Institute of Neuroscience, Section of Cagliari, Cagliari, Italy
Neuropharmacology 57:496-501. 2009..These results suggest that strain-related differences in the sensitivity of mesolimbic dopamine transmission to nicotine might be involved in the reported differences in the reinforcing effect of nicotine in Lewis and Fischer 344 rats...- Differential adaptive properties of accumbens shell dopamine responses to ethanol as a drug and as a motivational stimulusValentina Bassareo
Department of Toxicology and Consiglio Nazionale delle Ricerche, Center for Neuropharmacology, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy
Eur J Neurosci 17:1465-72. 2003..These differences, in turn, are consistent with a role of nucleus accumbens shell dopamine in the mechanism of the behavioural effects of addictive drugs... - Morphine-conditioned single-trial place preference: role of nucleus accumbens shell dopamine receptors in acquisition, but not expressionSandro Fenu
Department of Toxicology, University of Cagliari, Via Ospedale 72, Cagliari 09124, Italy
Psychopharmacology (Berl) 187:143-53. 2006..CONCLUSION: These results indicate that DA D1 and D2 receptors in the NAc shell are involved in the acquisition of morphine-induced CPP... - Differences in dopamine responsiveness to drugs of abuse in the nucleus accumbens shell and core of Lewis and Fischer 344 ratsCristina Cadoni
CNR Institute of Neuroscience, Section of Cagliari, Cagliari, Italy
J Neurochem 103:487-99. 2007..0 mg/kg), to the highest dose of amphetamine (1.0 mg/kg) and to all doses of cocaine. These differences might be the basis for the different behavioral responses of these strains to drugs of abuse... - Role of dopamine D(1) receptors in caffeine-mediated ERK phosphorylation in the rat brainElio Acquas
Department of Toxicology, University of Cagliari, I 09124 Cagliari, Italy
Synapse 64:341-9. 2010.... - Influence of morphine sensitization on the responsiveness of mesolimbic and mesocortical dopamine transmission to appetitive and aversive gustatory stimuliMaria Antonietta De Luca
Department of Toxicology, University of Cagliari, Via Ospedale 72, Cagliari, Italy
Psychopharmacology (Berl) 216:345-53. 2011..Repeated treatment with morphine has been shown to sensitize rats to its stimulant effects on motor activity and mesolimbic dopamine (DA) transmission... - Monitoring extracellular dopamine in the rat nucleus accumbens shell and core during acquisition and maintenance of intravenous WIN 55,212-2 self-administrationDaniele Lecca
Department of Toxicology, University of Cagliari, Via Ospedale 72, 09124, Cagliari, Italy
Psychopharmacology (Berl) 188:63-74. 2006..Increase in NAc DA is strictly related to WIN 55,212-2 actions because it is not observed during extinction despite active responding... - Differential effects of intravenous R,S-(+/-)-3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) and its S(+)- and R(-)-enantiomers on dopamine transmission and extracellular signal regulated kinase phosphorylation (pERK) in the rat nucleus accumbens shellElio Acquas
Department of Toxicology, University of Cagliari, Cagliari, Italy
J Neurochem 102:121-32. 2007.... - Reciprocal effects of response contingent and noncontingent intravenous heroin on in vivo nucleus accumbens shell versus core dopamine in the rat: a repeated sampling microdialysis studyDaniele Lecca
Department of Toxicology, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy
Psychopharmacology (Berl) 194:103-16. 2007..Although passive administration of heroin to drug-naive rats increases extracellular dopamine (DA) in the nucleus accumbens (NAc), its ability to do so also after active drug exposure (self-administration) is debated... - Differential involvement of dopamine D1 receptors in morphine- and lithium-conditioned saccharin avoidanceSandro Fenu
Department of Toxicology, University of Cagliari, Cagliari, Italy
Physiol Behav 96:73-7. 2009.... - Reciprocal responsiveness of nucleus accumbens shell and core dopamine to food- and drug-conditioned stimuliValentina Bassareo
Department of Toxicology, CNR Institute of Neuroscience, Section of Cagliari, National Institute of Neuroscience, University of Cagliari, Via Ospedale 72, 09124, Cagliari, Italy
Psychopharmacology (Berl) 214:687-97. 2011..Drugs of abuse and palatable food share the ability to stimulate dopamine (DA) transmission in the nucleus accumbens shell. However, while the stimulation of shell DA by food undergoes habituation, that by drugs of abuse does not... - Nicotine-conditioned single-trial place preference: selective role of nucleus accumbens shell dopamine D1 receptors in acquisitionLiliana Spina
Department of Toxicology, Centre of Excellence for Studies on the Neurobiology of Addiction, University of Cagliari and Institute of Neuroscience, Consiglio Nazionale delle Ricerche, Cagliari, Italy
Psychopharmacology (Berl) 184:447-55. 2006..CONCLUSIONS: The results indicate that dopamine D1 but not D2 receptors of the NAc shell are specifically involved in the acquisition of nicotine-induced CPP... - Conditioned saccharin avoidance and sensitization to drugs of abuseSandro Fenu
Department of Toxicology, University of Cagliari, Via Ospedale 72 09124 Cagliari, Italy
Behav Brain Res 214:248-53. 2010..The results are consistent with the hypothesis that NAc shell DA is a substrate of the appetitive properties of drugs of abuse... - Preferential increase of extracellular dopamine in the rat nucleus accumbens shell as compared to that in the core during acquisition and maintenance of intravenous nicotine self-administrationDaniele Lecca
Department of Toxicology, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy
Psychopharmacology (Berl) 184:435-46. 2006..Increase in NAc DA is strictly related to nicotine action since is not observed during extinction in spite of active responding... - Differential effects of caffeine on dopamine and acetylcholine transmission in brain areas of drug-naive and caffeine-pretreated ratsElio Acquas
Department of Toxicology, University of Cagliari, and Centre for Neuropharmacology - CNR, Via Ospedale72, I-09124, Cagliari, Italy
Neuropsychopharmacology 27:182-93. 2002.... - Behavioral sensitization to delta 9-tetrahydrocannabinol and cross-sensitization with morphine: differential changes in accumbal shell and core dopamine transmissionCristina Cadoni
C N R Institute of Neuroscience, Cagliari, Italy
J Neurochem 106:1586-93. 2008.... - Effect of 3,4-methylendioxymethamphetamine (MDMA, "ecstasy") on dopamine transmission in the nucleus accumbens shell and coreCristina Cadoni
CNR Istitute of Neuroscience, Section of Cagliari, Cagliari, Italy
Brain Res 1055:143-8. 2005..2 mg/kg was not significantly different in the shell compared to the core of nucleus accumbens. This study extends to MDMA the property of other drugs of abuse to increase preferentially nucleus accumbens shell dopamine... - Reward system and addiction: what dopamine does and doesn't doGaetano Di Chiara
Department of Toxicology, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy
Curr Opin Pharmacol 7:69-76. 2007.... - Cumulative effect of norepinephrine and dopamine carrier blockade on extracellular dopamine increase in the nucleus accumbens shell, bed nucleus of stria terminalis and prefrontal cortexEzio Carboni
Department of Toxicology and Centre of Excellence on Neurobiology of Addiction, University of Cagliari, Cagliari, Italy
J Neurochem 96:473-81. 2006..This phenomenon may have relevance in psychostimulant dependence as well as in antidepressant pharmacology... - Effect of amphetamine, cocaine and depolarization by high potassium on extracellular dopamine in the nucleus accumbens shell of SHR rats. An in vivo microdyalisis studyEzio Carboni
Department of Toxicology, Centro di Eccellenza sulla Neurobiologia delle Dipendenze, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy
Neurosci Biobehav Rev 27:653-9. 2003.... - Facilitation of conditioned taste aversion learning by systemic amphetamine: role of nucleus accumbens shell dopamine D1 receptorsSandro Fenu
Department of Toxicology, Centre of Excellence on Neurobiology of Addiction, University of Cagliari and Institute of Neuroscience Consiglio Nazionale delle Ricerche, Via Ospedale 72, 09124 Cagliari, Italy
Eur J Neurosci 18:2025-30. 2003..It is concluded that amphetamine facilitates CTA learning by strengthening the consolidation of gustatory short-term memory via D1 receptors of the NAc shell... - Dopamine in disturbances of food and drug motivated behavior: a case of homology?Gaetano Di Chiara
Department of Toxicology, University of Cagliari, Italy
Physiol Behav 86:9-10. 2005..It is speculated that disturbances of feeding behavior are related to loss of adaptive regulation of food-stimulated release of dopamine in the shell of the accumbens... - Selective psychostimulant sensitization by food restriction: differential changes in accumbens shell and core dopamineCristina Cadoni
Department of Toxicology, University of Cagliari and Centre of Excellence for Neurobiology of Addiction, Via Ospedale 72, 09124 Cagliari, Italy
Eur J Neurosci 18:2326-34. 2003..The present results indicate that a sensitized dopamine response in the nucleus accumbens core is a general feature of the expression of behavioural sensitization... - Differential influence of morphine sensitization on accumbens shell and core dopamine responses to morphine- and food-conditioned stimuliValentina Bassareo
Department of Biomedical Sciences, National Institute of Neuroscience, University of Cagliari, Via Ospedale 72, Cagliari, Italy
Psychopharmacology (Berl) 225:697-706. 2013..Sensitization of the incentive and dopamine (DA) stimulant properties of drug-conditioned stimuli (CSs) by repeated exposure to drugs of abuse has been assigned an important role in the genesis of drug addiction... - Lesion of medial prefrontal dopamine terminals abolishes habituation of accumbens shell dopamine responsiveness to taste stimuliZisis Bimpisidis
Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy
Eur J Neurosci 37:613-22. 2013..Moreover, habituation of DA responsiveness in the NAc shell is dependent upon an intact DA input to the mPFC... - Differential Expression of Motivational Stimulus Properties by Dopamine in Nucleus Accumbens Shell versus Core and Prefrontal CortexValentina Bassareo
Department of Toxicology and Consiglio Nazionale delle Ricerche, Center for Neuropharmacology, University of Cagliari, 09124 Cagliari, Italy
J Neurosci 22:4709-19. 2002..These observations indicate that DA responsiveness is an integrated function of the motivational valence and novelty of stimuli in the NAc shell and an expression of generic motivational value in the NAc core and PFCX... - Long-term increase in GAD67 mRNA expression in the central amygdala of rats sensitized by drugs and stressAnna R Carta
Department of Toxicology, University of Cagliari, Cagliari, Italy
Eur J Neurosci 27:1220-30. 2008....