Gaetano Di Chiara

Summary

Country: Italy

Publications

  1. ncbi request reprint Drug addiction as dopamine-dependent associative learning disorder
    G Di Chiara
    Department of Toxicology and CNR Center for Neuropharmacology, University of Cagliari, Italy
    Eur J Pharmacol 375:13-30. 1999
  2. ncbi request reprint Role of dopamine in the behavioural actions of nicotine related to addiction
    G Di Chiara
    Department of Toxicology and CNR Center of Neuropharmacology, University of Cagliari, Viale Diaz 182, 09100 Cagliari, Italy
    Eur J Pharmacol 393:295-314. 2000
  3. ncbi request reprint From rats to humans and return: testing addiction hypotheses by combined PET imaging and self-reported measures of psychostimulant effects. Commentary on Volkow et al. 'Role of dopamine in drug reinforcement and addiction in humans: results from imaging s
    G Di Chiara
    Department of Toxicology, University of Cagliari, V Ospedale 42, 09124 Cagliari, Italy
    Behav Pharmacol 13:371-7. 2002
  4. ncbi request reprint Nucleus accumbens shell and core dopamine: differential role in behavior and addiction
    Gaetano Di Chiara
    Department of Toxicology, Center of Excellence for Studies on Dependence CESID and CNR Neuroscience Institute, University of Cagliari, Via Ospedale, 72 I 09124, Cagliari, Italy
    Behav Brain Res 137:75-114. 2002
  5. ncbi request reprint Differential neurochemical and behavioral adaptation to cocaine after response contingent and noncontingent exposure in the rat
    Daniele Lecca
    Department of Toxicology, University of Cagliari, Via Ospedale 72, 09124, Cagliari, Italy
    Psychopharmacology (Berl) 191:653-67. 2007
  6. ncbi request reprint Dopamine and drug addiction: the nucleus accumbens shell connection
    Gaetano Di Chiara
    Department of Toxicology, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy
    Neuropharmacology 47:227-41. 2004
  7. ncbi request reprint Differential impact of pavlovian drug conditioned stimuli on in vivo dopamine transmission in the rat accumbens shell and core and in the prefrontal cortex
    Valentina Bassareo
    Department of Toxicology and Center of Excellence for Studies on Dependence, University of Cagliari, Cagliari, Italy
    Psychopharmacology (Berl) 191:689-703. 2007
  8. doi request reprint Nicotine differentially affects dopamine transmission in the nucleus accumbens shell and core of Lewis and Fischer 344 rats
    Cristina Cadoni
    CNR Institute of Neuroscience, Section of Cagliari, Cagliari, Italy
    Neuropharmacology 57:496-501. 2009
  9. ncbi request reprint Differential adaptive properties of accumbens shell dopamine responses to ethanol as a drug and as a motivational stimulus
    Valentina Bassareo
    Department of Toxicology and Consiglio Nazionale delle Ricerche, Center for Neuropharmacology, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy
    Eur J Neurosci 17:1465-72. 2003
  10. ncbi request reprint Morphine-conditioned single-trial place preference: role of nucleus accumbens shell dopamine receptors in acquisition, but not expression
    Sandro Fenu
    Department of Toxicology, University of Cagliari, Via Ospedale 72, Cagliari 09124, Italy
    Psychopharmacology (Berl) 187:143-53. 2006

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Drug addiction as dopamine-dependent associative learning disorder
    G Di Chiara
    Department of Toxicology and CNR Center for Neuropharmacology, University of Cagliari, Italy
    Eur J Pharmacol 375:13-30. 1999
    ....
  2. ncbi request reprint Role of dopamine in the behavioural actions of nicotine related to addiction
    G Di Chiara
    Department of Toxicology and CNR Center of Neuropharmacology, University of Cagliari, Viale Diaz 182, 09100 Cagliari, Italy
    Eur J Pharmacol 393:295-314. 2000
    ..Unavailability of tobacco disrupts the automatic, implicit modality of abnormal habit responding switching responding into the explicit, conscious modality of incentive drug-seeking and craving...
  3. ncbi request reprint From rats to humans and return: testing addiction hypotheses by combined PET imaging and self-reported measures of psychostimulant effects. Commentary on Volkow et al. 'Role of dopamine in drug reinforcement and addiction in humans: results from imaging s
    G Di Chiara
    Department of Toxicology, University of Cagliari, V Ospedale 42, 09124 Cagliari, Italy
    Behav Pharmacol 13:371-7. 2002
  4. ncbi request reprint Nucleus accumbens shell and core dopamine: differential role in behavior and addiction
    Gaetano Di Chiara
    Department of Toxicology, Center of Excellence for Studies on Dependence CESID and CNR Neuroscience Institute, University of Cagliari, Via Ospedale, 72 I 09124, Cagliari, Italy
    Behav Brain Res 137:75-114. 2002
    ....
  5. ncbi request reprint Differential neurochemical and behavioral adaptation to cocaine after response contingent and noncontingent exposure in the rat
    Daniele Lecca
    Department of Toxicology, University of Cagliari, Via Ospedale 72, 09124, Cagliari, Italy
    Psychopharmacology (Berl) 191:653-67. 2007
    ..Repeated exposure to the same drugs results in behavioral and biochemical sensitization characterized by stereotyped activity and reduction of the shell/core DA response ratio...
  6. ncbi request reprint Dopamine and drug addiction: the nucleus accumbens shell connection
    Gaetano Di Chiara
    Department of Toxicology, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy
    Neuropharmacology 47:227-41. 2004
    ..It is speculated that drug addiction results from the impact exerted on behavior by the abnormal DA stimulant properties acquired by drug-conditioned stimuli as a result of their association with addictive drugs...
  7. ncbi request reprint Differential impact of pavlovian drug conditioned stimuli on in vivo dopamine transmission in the rat accumbens shell and core and in the prefrontal cortex
    Valentina Bassareo
    Department of Toxicology and Center of Excellence for Studies on Dependence, University of Cagliari, Cagliari, Italy
    Psychopharmacology (Berl) 191:689-703. 2007
    ..Conditioned stimuli (CSs) by pavlovian association with reinforcing drugs (US) are thought to play an important role in the acquisition, maintenance and relapse of drug dependence...
  8. doi request reprint Nicotine differentially affects dopamine transmission in the nucleus accumbens shell and core of Lewis and Fischer 344 rats
    Cristina Cadoni
    CNR Institute of Neuroscience, Section of Cagliari, Cagliari, Italy
    Neuropharmacology 57:496-501. 2009
    ..These results suggest that strain-related differences in the sensitivity of mesolimbic dopamine transmission to nicotine might be involved in the reported differences in the reinforcing effect of nicotine in Lewis and Fischer 344 rats...
  9. ncbi request reprint Differential adaptive properties of accumbens shell dopamine responses to ethanol as a drug and as a motivational stimulus
    Valentina Bassareo
    Department of Toxicology and Consiglio Nazionale delle Ricerche, Center for Neuropharmacology, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy
    Eur J Neurosci 17:1465-72. 2003
    ..These differences, in turn, are consistent with a role of nucleus accumbens shell dopamine in the mechanism of the behavioural effects of addictive drugs...
  10. ncbi request reprint Morphine-conditioned single-trial place preference: role of nucleus accumbens shell dopamine receptors in acquisition, but not expression
    Sandro Fenu
    Department of Toxicology, University of Cagliari, Via Ospedale 72, Cagliari 09124, Italy
    Psychopharmacology (Berl) 187:143-53. 2006
    ..A large body of evidence indicates an involvement of the mesolimbic dopamine (DA) pathway innervating the ventral striatum in the motivational effects of drug abuse...
  11. ncbi request reprint Differences in dopamine responsiveness to drugs of abuse in the nucleus accumbens shell and core of Lewis and Fischer 344 rats
    Cristina Cadoni
    CNR Institute of Neuroscience, Section of Cagliari, Cagliari, Italy
    J Neurochem 103:487-99. 2007
    ..0 mg/kg), to the highest dose of amphetamine (1.0 mg/kg) and to all doses of cocaine. These differences might be the basis for the different behavioral responses of these strains to drugs of abuse...
  12. doi request reprint Role of dopamine D(1) receptors in caffeine-mediated ERK phosphorylation in the rat brain
    Elio Acquas
    Department of Toxicology, University of Cagliari, I 09124 Cagliari, Italy
    Synapse 64:341-9. 2010
    ....
  13. doi request reprint Influence of morphine sensitization on the responsiveness of mesolimbic and mesocortical dopamine transmission to appetitive and aversive gustatory stimuli
    Maria Antonietta De Luca
    Department of Toxicology, University of Cagliari, Via Ospedale 72, Cagliari, Italy
    Psychopharmacology (Berl) 216:345-53. 2011
    ..Repeated treatment with morphine has been shown to sensitize rats to its stimulant effects on motor activity and mesolimbic dopamine (DA) transmission...
  14. ncbi request reprint Monitoring extracellular dopamine in the rat nucleus accumbens shell and core during acquisition and maintenance of intravenous WIN 55,212-2 self-administration
    Daniele Lecca
    Department of Toxicology, University of Cagliari, Via Ospedale 72, 09124, Cagliari, Italy
    Psychopharmacology (Berl) 188:63-74. 2006
    ....
  15. ncbi request reprint Differential effects of intravenous R,S-(+/-)-3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) and its S(+)- and R(-)-enantiomers on dopamine transmission and extracellular signal regulated kinase phosphorylation (pERK) in the rat nucleus accumbens shell
    Elio Acquas
    Department of Toxicology, University of Cagliari, Cagliari, Italy
    J Neurochem 102:121-32. 2007
    ....
  16. ncbi request reprint Reciprocal effects of response contingent and noncontingent intravenous heroin on in vivo nucleus accumbens shell versus core dopamine in the rat: a repeated sampling microdialysis study
    Daniele Lecca
    Department of Toxicology, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy
    Psychopharmacology (Berl) 194:103-16. 2007
    ..Although passive administration of heroin to drug-naive rats increases extracellular dopamine (DA) in the nucleus accumbens (NAc), its ability to do so also after active drug exposure (self-administration) is debated...
  17. doi request reprint Differential influence of morphine sensitization on accumbens shell and core dopamine responses to morphine- and food-conditioned stimuli
    Valentina Bassareo
    Department of Biomedical Sciences, National Institute of Neuroscience, University of Cagliari, Via Ospedale 72, Cagliari, Italy
    Psychopharmacology (Berl) 225:697-706. 2013
    ..Sensitization of the incentive and dopamine (DA) stimulant properties of drug-conditioned stimuli (CSs) by repeated exposure to drugs of abuse has been assigned an important role in the genesis of drug addiction...
  18. doi request reprint Differential involvement of dopamine D1 receptors in morphine- and lithium-conditioned saccharin avoidance
    Sandro Fenu
    Department of Toxicology, University of Cagliari, Cagliari, Italy
    Physiol Behav 96:73-7. 2009
    ....
  19. doi request reprint Reciprocal responsiveness of nucleus accumbens shell and core dopamine to food- and drug-conditioned stimuli
    Valentina Bassareo
    Department of Toxicology, CNR Institute of Neuroscience, Section of Cagliari, National Institute of Neuroscience, University of Cagliari, Via Ospedale 72, 09124, Cagliari, Italy
    Psychopharmacology (Berl) 214:687-97. 2011
    ..Drugs of abuse and palatable food share the ability to stimulate dopamine (DA) transmission in the nucleus accumbens shell. However, while the stimulation of shell DA by food undergoes habituation, that by drugs of abuse does not...
  20. ncbi request reprint Nicotine-conditioned single-trial place preference: selective role of nucleus accumbens shell dopamine D1 receptors in acquisition
    Liliana Spina
    Department of Toxicology, Centre of Excellence for Studies on the Neurobiology of Addiction, University of Cagliari and Institute of Neuroscience, Consiglio Nazionale delle Ricerche, Cagliari, Italy
    Psychopharmacology (Berl) 184:447-55. 2006
    ..However, the role of DA transmission of the two main subdivisions of the nucleus accumbens (NAc), the shell and the core, in the motivational properties of nicotine is unknown...
  21. doi request reprint Conditioned saccharin avoidance and sensitization to drugs of abuse
    Sandro Fenu
    Department of Toxicology, University of Cagliari, Via Ospedale 72 09124 Cagliari, Italy
    Behav Brain Res 214:248-53. 2010
    ..The results are consistent with the hypothesis that NAc shell DA is a substrate of the appetitive properties of drugs of abuse...
  22. ncbi request reprint Preferential increase of extracellular dopamine in the rat nucleus accumbens shell as compared to that in the core during acquisition and maintenance of intravenous nicotine self-administration
    Daniele Lecca
    Department of Toxicology, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy
    Psychopharmacology (Berl) 184:435-46. 2006
    ..To date, no information is available if this also applies to active, response-contingent nicotine administration...
  23. ncbi request reprint Differential effects of caffeine on dopamine and acetylcholine transmission in brain areas of drug-naive and caffeine-pretreated rats
    Elio Acquas
    Department of Toxicology, University of Cagliari, and Centre for Neuropharmacology CNR, Via Ospedale72, I 09124, Cagliari, Italy
    Neuropsychopharmacology 27:182-93. 2002
    ....
  24. doi request reprint Behavioral sensitization to delta 9-tetrahydrocannabinol and cross-sensitization with morphine: differential changes in accumbal shell and core dopamine transmission
    Cristina Cadoni
    C N R Institute of Neuroscience, Cagliari, Italy
    J Neurochem 106:1586-93. 2008
    ....
  25. ncbi request reprint Effect of 3,4-methylendioxymethamphetamine (MDMA, "ecstasy") on dopamine transmission in the nucleus accumbens shell and core
    Cristina Cadoni
    CNR Istitute of Neuroscience, Section of Cagliari, Cagliari, Italy
    Brain Res 1055:143-8. 2005
    ..2 mg/kg was not significantly different in the shell compared to the core of nucleus accumbens. This study extends to MDMA the property of other drugs of abuse to increase preferentially nucleus accumbens shell dopamine...
  26. ncbi request reprint Reward system and addiction: what dopamine does and doesn't do
    Gaetano Di Chiara
    Department of Toxicology, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy
    Curr Opin Pharmacol 7:69-76. 2007
    ....
  27. ncbi request reprint Cumulative effect of norepinephrine and dopamine carrier blockade on extracellular dopamine increase in the nucleus accumbens shell, bed nucleus of stria terminalis and prefrontal cortex
    Ezio Carboni
    Department of Toxicology and Centre of Excellence on Neurobiology of Addiction, University of Cagliari, Cagliari, Italy
    J Neurochem 96:473-81. 2006
    ..This phenomenon may have relevance in psychostimulant dependence as well as in antidepressant pharmacology...
  28. ncbi request reprint Effect of amphetamine, cocaine and depolarization by high potassium on extracellular dopamine in the nucleus accumbens shell of SHR rats. An in vivo microdyalisis study
    Ezio Carboni
    Department of Toxicology, Centro di Eccellenza sulla Neurobiologia delle Dipendenze, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy
    Neurosci Biobehav Rev 27:653-9. 2003
    ....
  29. ncbi request reprint Facilitation of conditioned taste aversion learning by systemic amphetamine: role of nucleus accumbens shell dopamine D1 receptors
    Sandro Fenu
    Department of Toxicology, Centre of Excellence on Neurobiology of Addiction, University of Cagliari and Institute of Neuroscience Consiglio Nazionale delle Ricerche, Via Ospedale 72, 09124 Cagliari, Italy
    Eur J Neurosci 18:2025-30. 2003
    ..It is concluded that amphetamine facilitates CTA learning by strengthening the consolidation of gustatory short-term memory via D1 receptors of the NAc shell...
  30. ncbi request reprint Dopamine in disturbances of food and drug motivated behavior: a case of homology?
    Gaetano Di Chiara
    Department of Toxicology, University of Cagliari, Italy
    Physiol Behav 86:9-10. 2005
    ..It is speculated that disturbances of feeding behavior are related to loss of adaptive regulation of food-stimulated release of dopamine in the shell of the accumbens...
  31. ncbi request reprint Selective psychostimulant sensitization by food restriction: differential changes in accumbens shell and core dopamine
    Cristina Cadoni
    Department of Toxicology, University of Cagliari and Centre of Excellence for Neurobiology of Addiction, Via Ospedale 72, 09124 Cagliari, Italy
    Eur J Neurosci 18:2326-34. 2003
    ..The present results indicate that a sensitized dopamine response in the nucleus accumbens core is a general feature of the expression of behavioural sensitization...
  32. doi request reprint Lesion of medial prefrontal dopamine terminals abolishes habituation of accumbens shell dopamine responsiveness to taste stimuli
    Zisis Bimpisidis
    Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy
    Eur J Neurosci 37:613-22. 2013
    ..Moreover, habituation of DA responsiveness in the NAc shell is dependent upon an intact DA input to the mPFC...
  33. ncbi request reprint Differential Expression of Motivational Stimulus Properties by Dopamine in Nucleus Accumbens Shell versus Core and Prefrontal Cortex
    Valentina Bassareo
    Department of Toxicology and Consiglio Nazionale delle Ricerche, Center for Neuropharmacology, University of Cagliari, 09124 Cagliari, Italy
    J Neurosci 22:4709-19. 2002
    ..These observations indicate that DA responsiveness is an integrated function of the motivational valence and novelty of stimuli in the NAc shell and an expression of generic motivational value in the NAc core and PFCX...
  34. doi request reprint Long-term increase in GAD67 mRNA expression in the central amygdala of rats sensitized by drugs and stress
    Anna R Carta
    Department of Toxicology, University of Cagliari, Cagliari, Italy
    Eur J Neurosci 27:1220-30. 2008
    ....