Giuseppe Derosa

Summary

Country: Italy

Publications

  1. ncbi request reprint Comparison of glycaemic control and cardiovascular risk profile in patients with type 2 diabetes during treatment with either repaglinide or metformin
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, IRCCS Policlinico S Matteo, P le C Golgi 2, 27100 Pavia, Italy
    Diabetes Res Clin Pract 60:161-9. 2003
  2. doi request reprint Comparison of orlistat treatment and placebo in obese type 2 diabetic patients
    Giuseppe Derosa
    University of Pavia, Department of Internal Medicine and Therapeutics, 27100 Pavia, Italy
    Expert Opin Pharmacother 11:1971-82. 2010
  3. ncbi request reprint Telmisartan and irbesartan therapy in type 2 diabetic patients treated with rosiglitazone: effects on insulin-resistance, leptin and tumor necrosis factor-alpha
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Hypertens Res 29:849-56. 2006
  4. ncbi request reprint Metalloproteinase-2 and -9 in diabetic and nondiabetic subjects during acute coronary syndromes
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico S Matteo, Pavia, Italy
    Endothelium 14:45-51. 2007
  5. doi request reprint Candesartan effect on inflammation in hypertension
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico S Matteo, Pavia, Italy
    Hypertens Res 33:209-13. 2010
  6. ncbi request reprint Metabolic and antihypertensive effects of moxonidine and moxonidine plus irbesartan in patients with type 2 diabetes mellitus and mild hypertension: a sequential, randomized, double-blind clinical trial
    Giuseppe Derosa
    Department o f Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico S Matteo, Pavia, Italy
    Clin Ther 29:602-10. 2007
  7. ncbi request reprint Long-term effects of glimepiride or rosiglitazone in combination with metformin on blood pressure control in type 2 diabetic patients affected by the metabolic syndrome: a 12-month, double-blind, randomized clinical trial
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Clin Ther 27:1383-91. 2005
  8. ncbi request reprint Effects of amlodipine-atorvastatin combination on inflammation markers and insulin sensitivity in normocholesterolemic obese hypertensive patients
    Roberto Fogari
    Department of Internal Medicine and Therapeutics, Clinica Medica II, IRCCS Policlinico S Matteo, University of Pavia, Piazzale Golgi 19, 27100, Pavia, Italy
    Eur J Clin Pharmacol 62:817-22. 2006
  9. doi request reprint Differential effects of candesartan and olmesartan on adipose tissue activity biomarkers in type II diabetic hypertensive patients
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Hypertens Res 33:790-5. 2010
  10. ncbi request reprint Pioglitazone metabolic effect in metformin-intolerant obese patients treated with sibutramine
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico S Matteo, Pavia, Italy
    Intern Med 48:265-71. 2009

Detail Information

Publications99

  1. ncbi request reprint Comparison of glycaemic control and cardiovascular risk profile in patients with type 2 diabetes during treatment with either repaglinide or metformin
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, IRCCS Policlinico S Matteo, P le C Golgi 2, 27100 Pavia, Italy
    Diabetes Res Clin Pract 60:161-9. 2003
    ..To compare glycaemic control and cardiovascular risk profile in patients with type 2 diabetes following 12 months' treatment with either repaglinide or metformin...
  2. doi request reprint Comparison of orlistat treatment and placebo in obese type 2 diabetic patients
    Giuseppe Derosa
    University of Pavia, Department of Internal Medicine and Therapeutics, 27100 Pavia, Italy
    Expert Opin Pharmacother 11:1971-82. 2010
    ..To evaluate the effects of 1-year treatment with orlistat compared with placebo on different inflammatory parameters in type 2 obese diabetic patients...
  3. ncbi request reprint Telmisartan and irbesartan therapy in type 2 diabetic patients treated with rosiglitazone: effects on insulin-resistance, leptin and tumor necrosis factor-alpha
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Hypertens Res 29:849-56. 2006
    ..These observed metabolic effects of different angiotensin type 1 receptor blockers could be relevant when choosing a therapy to correct metabolic derangement of patients affected by metabolic syndrome and diabetes...
  4. ncbi request reprint Metalloproteinase-2 and -9 in diabetic and nondiabetic subjects during acute coronary syndromes
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico S Matteo, Pavia, Italy
    Endothelium 14:45-51. 2007
    ..MMP-9, TIMP-1, and TIMP-2 plasma levels were increased in diabetic patients with ACSs, which may reflect abnormal extracellular matrix metabolism in diabetes during acute event...
  5. doi request reprint Candesartan effect on inflammation in hypertension
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico S Matteo, Pavia, Italy
    Hypertens Res 33:209-13. 2010
    ..We observed that candesartan treatment attenuated the inflammatory answer in both groups of patients, even if more efficiently in nondiabetic ones...
  6. ncbi request reprint Metabolic and antihypertensive effects of moxonidine and moxonidine plus irbesartan in patients with type 2 diabetes mellitus and mild hypertension: a sequential, randomized, double-blind clinical trial
    Giuseppe Derosa
    Department o f Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico S Matteo, Pavia, Italy
    Clin Ther 29:602-10. 2007
    ..The autonomic nervous system plays an important part in the homeostasis of blood pressure (BP), and sympathetic overactivity may contribute to metabolic conditions such as glycemic intolerance or insulin resistance...
  7. ncbi request reprint Long-term effects of glimepiride or rosiglitazone in combination with metformin on blood pressure control in type 2 diabetic patients affected by the metabolic syndrome: a 12-month, double-blind, randomized clinical trial
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Clin Ther 27:1383-91. 2005
    ..Based on a literature search, few direct comparisons of different antihyperglycemic treatments on blood pressure have been reported...
  8. ncbi request reprint Effects of amlodipine-atorvastatin combination on inflammation markers and insulin sensitivity in normocholesterolemic obese hypertensive patients
    Roberto Fogari
    Department of Internal Medicine and Therapeutics, Clinica Medica II, IRCCS Policlinico S Matteo, University of Pavia, Piazzale Golgi 19, 27100, Pavia, Italy
    Eur J Clin Pharmacol 62:817-22. 2006
    ..The objective of this study was to assess the effect of amlodipine-atorvastatin combination on plasma interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and insulin sensitivity in normocholesterolemic obese hypertensive patients...
  9. doi request reprint Differential effects of candesartan and olmesartan on adipose tissue activity biomarkers in type II diabetic hypertensive patients
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Hypertens Res 33:790-5. 2010
    ..Both treatments resulted in a similar reduction in Hs-CRP. Although both therapies resulted in similar reductions in blood pressure, candesartan therapy was more effective than olmesartan therapy in improving insulin sensitivity...
  10. ncbi request reprint Pioglitazone metabolic effect in metformin-intolerant obese patients treated with sibutramine
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico S Matteo, Pavia, Italy
    Intern Med 48:265-71. 2009
    ..We aimed to comparatively test the efficacy and tolerability of pioglitazone and sibutramine in metformin-intolerant obese type 2 diabetic patients treated with sibutramine...
  11. ncbi request reprint Blood pressure control and inflammatory markers in type 2 diabetic patients treated with pioglitazone or rosiglitazone and metformin
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico S Matteo, Pavia, Italy
    Hypertens Res 30:387-94. 2007
    ....
  12. doi request reprint Sibutramine effect on metabolic control of obese patients with type 2 diabetes mellitus treated with pioglitazone
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, 19 27100 Pavia, Italy
    Metabolism 57:1552-7. 2008
    ..Sibutramine appears to be a tolerable and efficacious drug when added to pioglitazone for the global management of obese diabetic patients...
  13. doi request reprint Comparison between orlistat plus l-carnitine and orlistat alone on inflammation parameters in obese diabetic patients
    Giuseppe Derosa
    Fondazione IRCCS Policlinico S Matteo, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, P le C Golgi, 2 27100 Pavia, Italy
    Fundam Clin Pharmacol 25:642-51. 2011
    ....
  14. doi request reprint Role of angiotensin II in plasma PAI-1 changes induced by imidapril or candesartan in hypertensive patients with metabolic syndrome
    Roberto Fogari
    Department of Internal Medicine and Therapeutics, Centro Ipertensione e Fisiopatologia Cardiovascolare, University of Pavia, Pavia, Italy
    Hypertens Res 34:1321-6. 2011
    ..This suggests that the different effect of angiotensin-converting enzyme inhibitors and Ang II blockers on Ang II production has a role in their different influence on fibrinolysis...
  15. ncbi request reprint Effects of 1 year of treatment with pioglitazone or rosiglitazone added to glimepiride on lipoprotein (a) and homocysteine concentrations in patients with type 2 diabetes mellitus and metabolic syndrome: a multicenter, randomized, double-blind, controlled
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Clin Ther 28:679-88. 2006
    ....
  16. doi request reprint Effects of manidipine/delapril versus olmesartan/hydrochlorothiazide combination therapy in elderly hypertensive patients with type 2 diabetes mellitus
    Roberto Fogari
    Department of Internal Medicine and Therapeutics, Clinica Medica II Fondazione IRCCS Policlinico S Matteo, University of Pavia, Italy
    Hypertens Res 31:43-50. 2008
    ..However, manidipine/delapril offered some advantages in terms of the less-pronounced BP orthostatic changes and absence of metabolic adverse effects...
  17. doi request reprint Modulation of adipokines and vascular remodelling markers during OGTT with acarbose or pioglitazone treatment
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico S Matteo, P le C Golgi 2, 27100 Pavia, Italy
    Biomed Pharmacother 63:723-33. 2009
    ..Pioglitazone improves glucose metabolism and insulin-resistance compared to acarbose in type 2 diabetic patients already treated with metformin and sulphonilureas...
  18. ncbi request reprint Evaluation of metalloproteinase 2 and 9 levels and their inhibitors in combined dyslipidemia
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Clin Invest Med 32:E124-32. 2009
    ..To evaluate the distribution of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), and their specific inhibitors in a sample of patients affected by mild dyslipidemia but not yet treated with antihyperlipidemic drugs...
  19. doi request reprint A randomized, double-blind, comparative therapy evaluating sitagliptin versus glibenclamide in type 2 diabetes patients already treated with pioglitazone and metformin: a 3-year study
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Diabetes Technol Ther 15:214-22. 2013
    ..Furthermore, we also compared a triple metformin+pioglitazone+glibenclamide combination with a metformin+pioglitazone+sitagliptin one...
  20. doi request reprint Vildagliptin added to metformin on β-cell function after a euglycemic hyperinsulinemic and hyperglycemic clamp in type 2 diabetes patients
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Diabetes Technol Ther 14:475-84. 2012
    ..This study evaluated the effect of vildagliptin + metformin on glycemic control and β-cell function in type 2 diabetes patients...
  21. doi request reprint Effects of losartan and amlodipine alone or combined with simvastatin in hypertensive patients with nonalcoholic hepatic steatosis
    Roberto Fogari
    Department of Internal Medicine and Therapeutics, Centro Ipertensione e Fisiopatologia Cardiovascolare, University of Pavia, Pavia, Italy
    Eur J Gastroenterol Hepatol 24:164-71. 2012
    ....
  22. doi request reprint Direct comparison among oral hypoglycemic agents and their association with insulin resistance evaluated by euglycemic hyperinsulinemic clamp: the 60's study
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico S Matteo, 2 27100 Pavia, Italy
    Metabolism 58:1059-66. 2009
    ..Pioglitazone-metformin-based therapeutic control is associated with the most quantitatively relevant improvement in insulin resistance-related parameters, whereas the sulfonylurea-metformin-including protocol has less relevant effects...
  23. doi request reprint Effects of a standardized oral fat load on vascular remodelling markers in healthy subjects
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
    Microvasc Res 80:110-5. 2010
    ..We observed that nitrites/nitrates and ADP significantly decreased and MMP-2 and MMP-9 significantly increased after a standardized OFL. Other studies need to confirm the direct acute effects of post-prandial lipemia on vascular damage...
  24. doi request reprint Effects of sitagliptin or metformin added to pioglitazone monotherapy in poorly controlled type 2 diabetes mellitus patients
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Metabolism 59:887-95. 2010
    ....
  25. ncbi request reprint A comparison of the effects of pioglitazone and rosiglitazone combined with glimepiride on prothrombotic state in type 2 diabetic patients with the metabolic syndrome
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, P le C Golgi, 2 27100 Pavia, Italy
    Diabetes Res Clin Pract 69:5-13. 2005
    ..To compare the effects of glimepiride plus pioglitazone or plus rosiglitazone in diabetic patients with the metabolic syndrome on coagulation and fibrinolysis parameters...
  26. doi request reprint Different actions of losartan and ramipril on adipose tissue activity and vascular remodeling biomarkers in hypertensive patients
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico S Matteo, Pavia, Italy
    Hypertens Res 34:145-51. 2011
    ....
  27. doi request reprint Effects of combination of sibutramine and L-carnitine compared with sibutramine monotherapy on inflammatory parameters in diabetic patients
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, 27100 Pavia, Italy
    Metabolism 60:421-9. 2011
    ..Sibutramine plus L-carnitine gave a better and faster improvement of all the analyzed parameters compared with sibutramine alone without giving any severe adverse effect...
  28. doi request reprint Effects of a combination of sitagliptin plus metformin vs metformin monotherapy on glycemic control, β-cell function and insulin resistance in type 2 diabetic patients
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Diabetes Res Clin Pract 98:51-60. 2012
    ..To evaluate the impact on glycemic control, insulin resistance, and insulin secretion of sitagliptin+metformin compared to metformin in type 2 diabetic patients...
  29. doi request reprint Effects of n-3 PUFAs on postprandial variation of metalloproteinases, and inflammatory and insulin resistance parameters in dyslipidemic patients: evaluation with euglycemic clamp and oral fat load
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    J Clin Lipidol 6:553-64. 2012
    ..The oral fat load (OFL) is considered as one of the most accurate models of postprandial lipoprotein metabolism and it has been widely used to evaluate the postprandial fat load effect on single markers of inflammation...
  30. ncbi request reprint Effect of telmisartan-amlodipine combination at different doses on urinary albumin excretion in hypertensive diabetic patients with microalbuminuria
    Roberto Fogari
    Department of Internal Medicine and Therapeutics, Clinica Medica II IRCCS Policlinico S Matteo, University of Pavia, Pavia, Italy
    Am J Hypertens 20:417-22. 2007
    ..Aim of this study was to evaluate the effect of the telmisartan-amlodipine combination at different doses on urinary albumin excretion rate (UAER) in hypertensive diabetic patients with microalbuminuria...
  31. ncbi request reprint Effect of delapril/manidipine vs olmesartan/ hydrochlorothiazide combination on insulin sensitivity and fibrinogen in obese hypertensive patients
    Roberto Fogari
    Department of Internal Medicine and Therapeutics, Centro per l Ipertensione e la Fisiopatologia Cardiovascolare, University of Pavia, Italy
    Intern Med 47:361-6. 2008
    ..To compare the effect of delapril/manidipine vs olmesartan/hydrochlorothiazide (HCTZ) combination on insulin sensitivity and plasma fibrinogen in obese hypertensive patients...
  32. ncbi request reprint Antithrombotic effects of rosiglitazone-metformin versus glimepiride-metformin combination therapy in patients with type 2 diabetes mellitus and metabolic syndrome
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Italy
    Pharmacotherapy 25:637-45. 2005
    ....
  33. doi request reprint Rosiglitazone therapy improves insulin resistance parameters in overweight and obese diabetic patients intolerant to metformin
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Arch Med Res 39:412-9. 2008
    ....
  34. ncbi request reprint Comparison of the effects of telmisartan and nifedipine gastrointestinal therapeutic system on blood pressure control, glucose metabolism, and the lipid profile in patients with type 2 diabetes mellitus and mild hypertension: a 12-month, randomized, doubl
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Clin Ther 26:1228-36. 2004
    ..Angiotensin receptor blockers (ARBs) provide effective blood pressure control. Whereas none of the ARBs appear to affect glucose homeostasis, some ARBs have been associated with a decrease in cholesterolemia...
  35. doi request reprint Time course of antiproteinuric effect of aliskiren in arterial hypertension associated with type 2 diabetes and microalbuminuria
    Roberto Fogari
    University of Pavia, Clinica Medica II, Centro Ipertensione e Fisiopatologia Cardiovascolare, Department of Internal Medicine and Therapeutics, Piazzale Golgi 19, 27100 Pavia, Italy
    Expert Opin Pharmacother 14:371-84. 2013
    ..The aim was to compare the antiproteinuric effect of aliskiren and ramipril in hypertensive patients with type 2 diabetes and microalbuminuria...
  36. doi request reprint Effect of valsartan or olmesartan addition to amlodipine on ankle edema in hypertensive patients
    Roberto Fogari
    Clinica Medica II, Centro Ipertensione e Fisiopatologia Cardiovascolare, Department of Internal Medicine and Therapeutics, University of Pavia, Italy
    Adv Ther 27:48-55. 2010
    ..The objective of this study was to compare the effect on ankle edema of adding valsartan (V) or olmesartan (O) to amlodipine (A) in the treatment of hypertension...
  37. doi request reprint Effect of valsartan and ramipril on atrial fibrillation recurrence and P-wave dispersion in hypertensive patients with recurrent symptomatic lone atrial fibrillation
    Roberto Fogari
    Department of Internal Medicine and Therapeutics, Centro per l Ipertensione e la Fisiopatologia Cardiovascolare, University of Pavia, Pavia, Italy
    Am J Hypertens 21:1034-9. 2008
    ..This study compared the effect of antihypertensive treatment with valsartan or ramipril on atrial fibrillation (AF) recurrence, on P-wave dispersion, (PWD) and on serum procollagen type I carboxy terminal peptide (PIP)...
  38. doi request reprint Oral fat load effects on inflammation and endothelial stress markers in healthy subjects
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS, Policlinico San Matteo, P C Golgi 2, 27100 Pavia, Italy
    Heart Vessels 24:204-10. 2009
    ..05 vs 0), and +28.57% at 12 h. We observed that the OFL induces a complex and massive systemic inflammatory response that includes IL-6, TNF-alpha, hsCRP, and cell adhesion molecules, even before Tg significantly rises...
  39. doi request reprint Acarbose actions on insulin resistance and inflammatory parameters during an oral fat load
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Eur J Pharmacol 651:240-50. 2011
    ..Acarbose was more effective than acarbose in reducing the post-OFL peaks of the various parameters included the inflammatory markers, after 7months of therapy...
  40. ncbi request reprint Effects of one year treatment of sibutramine on insulin resistance parameters in type 2 diabetic patients
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, P le C Golgi, 2 27100 Pavia, Italy
    J Pharm Pharm Sci 13:378-90. 2010
    ..Comparison of the effects of one year treatment with sibutramine compared to placebo on insulin resistance parameters, body weight, glycemic control, and lipid profile, in type 2 diabetic patients...
  41. ncbi request reprint Effects of insulin therapy with continuous subcutaneous insulin infusion (CSII) in diabetic patients: comparison with multi-daily insulin injections therapy (MDI)
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Endocr J 56:571-8. 2009
    ..CSII therapy allows a faster and better achievement of the therapeutic target and also gives an improvement of the lipid profile...
  42. ncbi request reprint Synergistic effect of doxazosin and acarbose in improving metabolic control in patients with impaired glucose tolerance
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Clin Drug Investig 26:529-39. 2006
    ..The aim of this study was to evaluate if the expected improvement in glucose and lipid metabolism obtainable with doxazosin is or is not synergistic with standard antihyperglycaemic treatment using the alpha-glucosidase inhibitor acarbose...
  43. doi request reprint Variation of some inflammatory markers in hypertensive patients after 1 year of olmesartan/amlodipine single-pill combination compared with olmesartan or amlodipine monotherapies
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Italy
    J Am Soc Hypertens 7:32-9. 2013
    ..The olmesartan/amlodipine combination is effective and safe in reducing blood pressure and has some additive effects not shown by single drugs, such as an improvement of IL-7...
  44. doi request reprint Effects of valsartan versus olmesartan addition to amlodipine/hydrochlorothiazide combination in treating stage 2 hypertensive patients
    Roberto Fogari
    Clinica Medica II, Centro Ipertensione e Fisiopatologia Cardiovascolare, Department of Internal Medicine and Therapeutics, University of Pavia, Piazzale Golgi 19, 27100 Pavia, Italy
    Expert Opin Pharmacother 13:629-36. 2012
    ..The objective of this study was to assess the effects of valsartan or olmesartan addition to dual therapy with amlodipine + hydrochlorothiazide (HCTZ) in the treatment of stage 2 hypertension...
  45. doi request reprint Comparative evaluation of effect of valsartan/amlodipine and atenolol/amlodipine combinations on atrial fibrillation recurrence in hypertensive patients with type 2 diabetes mellitus
    Roberto Fogari
    Department of Internal Medicine and Therapeutics, Centro per l Ipertensione e la Fisiopatologia Cardiovascolare, University of Pavia, Pavia, Italy
    J Cardiovasc Pharmacol 51:217-22. 2008
    ..Despite similar BP reduction, valsartan/amlodipine combination was more effective in patients treated with amiodarone or propafenone than atenolol/amlodipine in preventing new episodes of AF in hypertensive diabetic patients...
  46. doi request reprint Modification of vascular and inflammation biomarkers after OGTT in overweight healthy and diabetic subjects
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico S Matteo, Pavia, P le C Golgi, 2 27100 Pavia, Italy
    Microvasc Res 79:144-9. 2010
    ..MMP-9 levels were higher in D group than in H group during OGTT. Postprandial glycemia induces an acute increase in biomarkers of vascular remodelling...
  47. ncbi request reprint Thiazolidinedione effects on blood pressure in diabetic patients with metabolic syndrome treated with glimepiride
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Italy
    Hypertens Res 28:917-24. 2005
    ....
  48. ncbi request reprint Orlistat and L-carnitine compared to orlistat alone on insulin resistance in obese diabetic patients
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Endocr J 57:777-86. 2010
    ....
  49. doi request reprint Effect of aliskiren addition to amlodipine on ankle edema in hypertensive patients: a three-way crossover study
    Roberto Fogari
    Clinica Medica II, University of Pavia, Centro Ipertensione e Fisiopatologia Cardiovascolare, Department of Internal Medicine and Therapeutics, Pavia, Italy
    Expert Opin Pharmacother 12:1351-8. 2011
    ..The aim of this study was to assess the effect of aliskiren and amlopidine on ankle-foot volume (AFV) and pretibial subcutaneous tissue pressure (PSTP)...
  50. doi request reprint Fibrinolysis and insulin sensitivity in imidapril and candesartan (FISIC study) recipients with hypertension
    Roberto Fogari
    Department of Internal Medicine and Therapeutics, Clinica Medica II, Centro Ipertensione e Fisiopatologia Cardiovascolare, University of Pavia, Pavia, Italy
    Hypertens Res 34:509-15. 2011
    ....
  51. ncbi request reprint Metabolic effect of repaglinide or acarbose when added to a double oral antidiabetic treatment with sulphonylureas and metformin: a double-blind, cross-over, clinical trial
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Curr Med Res Opin 25:607-15. 2009
    ..The second endpoint was to evaluate which of these two treatment is more efficacious in the global management of glucose homeostasis in the enrolled patients...
  52. ncbi request reprint Matrix metalloproteinase-2, -9, and tissue inhibitor of metalloproteinase-1 in patients with hypertension
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Endothelium 13:227-31. 2006
    ..0001) and for TIMP-1 (p < .0001) in hypertensive patients. Plasma levels and activities of MMP-2, MMP-9, and TIMP-1 are increased in hypertensive patients, which may reflect abnormal ECM metabolism...
  53. doi request reprint Evaluation of the positive effects on insulin-resistance and β-cell measurements of vildagliptin in addition to metformin in type 2 diabetic patients
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Pharmacol Res 73:20-6. 2013
    ..Vildagliptin, in addition to metformin, proved to be effective in improving β-cell function and in reducing insulin resistance measurements...
  54. doi request reprint Effects of valsartan or ramipril addition to amlodipine/hydrochlorothiazide combination on left ventricular mass in diabetic hypertensive patients with left ventricular hypertrophy
    Roberto Fogari
    University of Pavia, Clinica Medica II, Centro Ipertensione e Fisiopatologia Cardiovascolare, Department of Internal Medicine and Therapeutics, Fondazione IRCC Policlinico S Matteo, Piazzale Golgi 19, 27100 Pavia, Italy
    Expert Opin Pharmacother 13:1091-9. 2012
    ..The objective of this study was to compare valsartan or ramipril addition to amlodipine + hydrochlorothiazide (HCTZ) on blood pressure (BP) and left ventricular hypertrophy (LVH) in hypertensive diabetic patients with LVH...
  55. doi request reprint Effect of telmisartan and ramipril on atrial fibrillation recurrence and severity in hypertensive patients with metabolic syndrome and recurrent symptomatic paroxysmal and persistent atrial fibrillation
    Roberto Fogari
    Department of Internal Medicine and Therapeutics, Centro per l Ipertensione e la Fisiopatologia Cardiovascolare, University of Pavia, Pavia, Italy
    J Cardiovasc Pharmacol Ther 17:34-43. 2012
    ..This could be related to a specific effect of telmisartan on atrial electric remodeling...
  56. doi request reprint Effect of telmisartan on paroxysmal atrial fibrillation recurrence in hypertensive patients with normal or increased left atrial size
    Roberto Fogari
    Department of Internal Medicine and Therapeutics, Center for Hypertension and Cardiovascular Physiopathology, University of Pavia, Pavia, Italy
    Clin Cardiol 35:359-64. 2012
    ....
  57. doi request reprint Effect of telmisartan addition to amlodipine on ankle edema development in treating hypertensive patients
    Roberto Fogari
    University of Pavia, Clinica Medica II, Centro Ipertensione e Fisiopatologia Cardiovascolare, Department of Internal Medicine and Therapeutics, Piazzale Golgi 19, 27100 Pavia, Italy
    Expert Opin Pharmacother 12:2441-8. 2011
    ..The objective of this research was to evaluate the effect of telmisartan addition to amlodipine, on peripheral edema in hypertensive patients...
  58. ncbi request reprint Metalloproteinases in diabetics and nondiabetics during acute coronary syndromes and after 3 months
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Endothelium 14:175-83. 2007
    ..MMPs and TIMP-1 and -2 plasma levels were alterated in nondiabetic and diabetic patients during ACS and after 3 months, which may reflect abnormal extracellular matrix metabolism in diabetes during and after acute event...
  59. ncbi request reprint Effect of valsartan addition to amlodipine on insulin sensitivity in overweight-obese hypertensive patients
    Roberto Fogari
    Department of Internal Medicine and Therapeutics, Centro per l Ipertensione e la Fisiopatologia Cardiovascolare, University of Pavia, Italy
    Intern Med 47:1851-7. 2008
    ..The aim of the study was to evaluate the effect of valsartan/amlodipine combination on insulin sensitivity in overweight-obese hypertensive patients...
  60. doi request reprint Acarbose on insulin resistance after an oral fat load: a double-blind, placebo controlled study
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Pavia, Italy
    J Diabetes Complications 25:258-66. 2011
    ..We evaluated the effects of acarbose on insulin resistance parameters in diabetic patients before and after a standardized oral fat load (OFL)...
  61. doi request reprint Efficacy and safety of two treatment combinations of hypertension in very elderly patients
    Roberto Fogari
    Department of Internal Medicine and Therapeutics, Centro per l Ipertensione e la Fisiopatologia Cardiovascolare, University of Pavia, Piazzale Golgi 19, I 27100 Pavia, Italy
    Arch Gerontol Geriatr 48:401-5. 2009
    ..However, valsartan/amlodipine offered some advantages in terms of less pronounced BP orthostatic changes and absence of metabolic adverse effects...
  62. ncbi request reprint Sibutramine and L-carnitine compared to sibutramine alone on insulin resistance in diabetic patients
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Intern Med 49:1717-25. 2010
    ..To evaluate the effects of one year of treatment with sibutramine plus L-carnitine compared to sibutramine on body weight, glycemic control, and insulin resistance state in type 2 diabetic patients...
  63. doi request reprint Effect of body weight loss and normalization on blood pressure in overweight non-obese patients with stage 1 hypertension
    Roberto Fogari
    Department of Internal Medicine and Therapeutics, Centro Ipertensione e Fisiopatologia Cardiovascolare, University of Pavia, Pavia, Italy
    Hypertens Res 33:236-42. 2010
    ..Half of the patients who had normalized BMI also had normalized BP, which could indicate that these patients essentially did not have a form of hypertension but that these effects were instead secondary to being overweight...
  64. doi request reprint Effects of amlodipine plus atorvastatin association in hypertensive hypercholesterolemic patients
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico S Matteo, Pavia, Italy
    Expert Rev Cardiovasc Ther 8:835-43. 2010
    ..For these reasons, the combination of amlodipine plus atorvastatin could be the treatment of choice in hypertensive and hypercholesterolemic patients...
  65. doi request reprint Time to achieve blood pressure goal with a combination versus a conventional monotherapy approach in hypertensive patients with metabolic syndrome
    Roberto Fogari
    Department of Internal Medicine and Therapeutics, Centro Ipertensione e Fisiopatologia Cardiovascolare, University of Pavia, Pavia, Italy
    Clin Exp Hypertens 32:245-50. 2010
    ..3%, ns). These results suggest that initial therapy with a V/A combination approach may be more quickly effective than a conventional sequential monotherapy approach in achieving target BP in hypertensive patients with metabolic syndrome...
  66. ncbi request reprint Comparison of the effects of valsartan and felodipine on plasma leptin and insulin sensitivity in hypertensive obese patients
    Roberto Fogari
    Department of Internal Medicine and Therapeutics, IRCCS Policlinico S Matteo, University of Pavia, Pavia, Italy
    Hypertens Res 28:209-14. 2005
    ..These results suggest that in hypertensive obese subjects, treatment with valsartan might offer an advantage over treatment with felodipine, since valsartan may help to improve obesity-related disorders in addition to lowering BP...
  67. doi request reprint Fenofibrate, simvastatin and their combination in the management of dyslipidaemia in type 2 diabetic patients
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico S Matteo, 2 27100 Pavia, Italy
    Curr Med Res Opin 25:1973-83. 2009
    ..We evaluated lipids, glycaemic, haemostatic, and inflammatory variables at baseline, and after 6 and 12 months...
  68. ncbi request reprint Effects of nateglinide and glibenclamide on prothrombotic factors in naïve type 2 diabetic patients treated with metformin: a 1-year, double-blind, randomized clinical trial
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Italy
    Intern Med 46:1837-46. 2007
    ..To evaluate the effect on coagulation and fibrinolysis parameters and on non-conventional cardiovascular risk factors of metformin plus nateglinide or glibenclamide in naïve type 2 diabetes patients...
  69. ncbi request reprint Efficacy and tolerability of candesartan cilexetil/hydrochlorothiazide and amlodipine in patients with poorly controlled mild-to-moderate essential hypertension
    Roberto Fogari
    Department of Internal Medicine and Therapeutics, Centro per l Ipertensione e la Fisiopatologia Cardiovascolare, University of Pavia, Pavia
    J Renin Angiotensin Aldosterone Syst 8:139-44. 2007
    ..Tolerance is an important clinical consideration in the chronic treatment of an asymptomatic disease...
  70. ncbi request reprint Effect of amlodipine-atorvastatin combination on fibrinolysis in hypertensive hypercholesterolemic patients with insulin resistance
    Roberto Fogari
    Department of Internal Medicine and Therapeutics, Clinica Medica II IRCCS Policlinico S Matteo, University of Pavia, Pavia, Italy
    Am J Hypertens 17:823-7. 2004
    ....
  71. ncbi request reprint A randomized, double-blind, controlled, parallel-group comparison of perindopril and candesartan in hypertensive patients with type 2 diabetes mellitus
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, IRCCS Policlinico S Matteo, Pavia, Italy
    Clin Ther 25:2006-21. 2003
    ....
  72. doi request reprint Exenatide or glimepiride added to metformin on metabolic control and on insulin resistance in type 2 diabetic patients
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Eur J Pharmacol 666:251-6. 2011
    ..Furthermore, adiponectin increase, and tumor necrosis factor-α reduction seem to be related to weight loss obtained with exenatide...
  73. ncbi request reprint Effects of amlodipine fosinopril combination on microalbuminuria in hypertensive type 2 diabetic patients
    Roberto Fogari
    Department of Internal Medicine and Therapeutics, Clinica Medica IRCCS Policlinico S Matteo, University of Pavia, Pavia, Italy
    Am J Hypertens 15:1042-9. 2002
    ..The aim of this study is to compare the long-term effect of amlodipine and fosinopril in monotherapy or in combination on urinary albumin excretion (UAE) in hypertensive diabetic patients...
  74. ncbi request reprint Comparison of fluvastatin + fenofibrate combination therapy and fluvastatin monotherapy in the treatment of combined hyperlipidemia, type 2 diabetes mellitus, and coronary heart disease: a 12-month, randomized, double-blind, controlled trial
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, P le C Golgi, 2 27100 Pavia, Italy
    Clin Ther 26:1599-607. 2004
    ..Diabetes risk is often complicated by a mixed hyperlipoproteinemia not sufficiently controlled by a single antihyperlipidemic drug; however, there are some concerns about the safety of combined statin and fibrate treatments...
  75. ncbi request reprint Effect of doxazosin on C-reactive protein plasma levels and on nitric oxide in patients with hypertension
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    J Cardiovasc Pharmacol 47:508-12. 2006
    ..05) in hypertensive patients after antihypertensive treatment. These results suggest that doxazosin treatment exerts anti-inflammatory effects in addition to its antihypertensive properties in hypertensive patients...
  76. pmc Valsartan addition to amlodipine is more effective than losartan addition in hypertensive patients inadequately controlled by amlodipine
    Roberto Fogari
    Department of Internal Medicine and Therapeutics, Centro Ipertensione e Fisiopatologia Cardiovascolare, University of Pavia, Pavia, Italy
    Vasc Health Risk Manag 6:87-93. 2010
    ..This study evaluated the effects on blood pressure (BP) of valsartan 160 mg or losartan 100 mg addition to amlodipine 5 mg in hypertensive patients...
  77. ncbi request reprint Comparison between repaglinide and glimepiride in patients with type 2 diabetes mellitus: a one-year, randomized, double-blind assessment of metabolic parameters and cardiovascular risk factors
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Clin Ther 25:472-84. 2003
    ..Repaglinide and glimepiride are relatively new oral hypoglycemic agents. Few data are available concerning their effects on metabolic parameters other than measures of glycemic control...
  78. ncbi request reprint Losartan and perindopril effects on plasma plasminogen activator inhibitor-1 and fibrinogen in hypertensive type 2 diabetic patients
    Roberto Fogari
    Department of Internal Medicine and Therapeutics, IRCCS Policlinico S Matteo, University of Pavia, Italy
    Am J Hypertens 15:316-20. 2002
    ..This study compared the effects of losartan and perindopril on plasma plasminogen activator inhibitor-1 (PAI-1) and fibrinogen in hypertensive type 2 diabetic patients...
  79. doi request reprint Effects of thiazolidinediones and sulfonylureas in patients with diabetes
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico S Matteo, Pavia, Italy
    Diabetes Technol Ther 12:491-501. 2010
    ..We also evaluated the effects of these two drugs on beta-cell function, insulin resistance, and inflammatory markers, also recording the frequency of adverse events such as edema and heart failure...
  80. ncbi request reprint Pioglitazone and rosiglitazone: effects of treatment with a thiazolidinedione on lipids and non conventional cardiovascular risk factors
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Piazzale C Golgi 2, Pavia, Italy
    Curr Clin Pharmacol 3:77-84. 2008
    ....
  81. ncbi request reprint Irbesartan and hydrochlorothiazide association in the treatment of hypertension
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
    Curr Vasc Pharmacol 7:120-36. 2009
    ..Ongoing trials about irbesartan and its combination with diuretics may provide necessary data to interpret the value of this association among others...
  82. ncbi request reprint Effects of telmisartan compared with eprosartan on blood pressure control, glucose metabolism and lipid profile in hypertensive, type 2 diabetic patients: a randomized, double-blind, placebo-controlled 12-month study
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Italy
    Hypertens Res 27:457-64. 2004
    ....
  83. ncbi request reprint Metabolic effects of pioglitazone and rosiglitazone in patients with diabetes and metabolic syndrome treated with glimepiride: a twelve-month, multicenter, double-blind, randomized, controlled, parallel-group trial
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Piazzale C Golgi 2, 27100 Pavia, Italy
    Clin Ther 26:744-54. 2004
    ..Glimepiride is approved as monotherapy and in combination with metformin or with insulin, whereas the combination of glimepiride with other antihyperglycemic drugs is under investigation...
  84. ncbi request reprint The effect of L-carnitine on plasma lipoprotein(a) levels in hypercholesterolemic patients with type 2 diabetes mellitus
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Clin Ther 25:1429-39. 2003
    ..A previous study has demonstrated that L-carnitine reduces plasma lipoprotein(a) (Lp[a]) levels in patients with hypercholesterolemia...
  85. ncbi request reprint Randomized, double-blind, placebo-controlled comparison of the action of orlistat, fluvastatin, or both an anthropometric measurements, blood pressure, and lipid profile in obese patients with hypercholesterolemia prescribed a standardized diet
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Clin Ther 25:1107-22. 2003
    ....
  86. ncbi request reprint Recommendations for the treatment of hypertension in patients with DM: critical evaluation based on clinical trials
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Curr Clin Pharmacol 1:21-33. 2006
    ....
  87. ncbi request reprint Effect of antihypertensive treatment with valsartan or atenolol on sexual activity and plasma testosterone in hypertensive men
    Roberto Fogari
    Department of Internal Medicine and Therapeutics, Clinica Medica IRCCS Policlinico S Matteo, University of Pavia, Piazzale Golgi 2, 27100 Pavia, Italy
    Eur J Clin Pharmacol 58:177-80. 2002
    ..To compare the effects of valsartan and atenolol on sexual activity and plasma testosterone in newly diagnosed, previously untreated, essential hypertensive male subjects...
  88. ncbi request reprint Effects of doxazosin and irbesartan on blood pressure and metabolic control in patients with type 2 diabetes and hypertension
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    J Cardiovasc Pharmacol 45:599-604. 2005
    ..In conclusion, both doxazosin and irbesartan reduced BP during long-term treatment, but not to recommended levels, and doxazosin had the more beneficial effect on glucose metabolism and lipid profile...
  89. ncbi request reprint Matrix metalloproteinase 2 may be a marker of microangiopathy in children and adolescents with type 1 diabetes mellitus
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, P le C Golgi 2, 27100 Pavia, Italy
    Diabetes Res Clin Pract 70:119-25. 2005
    ..It is well known that MMP-9 is an index of the severity and stability of macroangiopathy while our results allow us to postulate that MMP-2 may be a marker of microangiopathy...
  90. ncbi request reprint Association between low-molecular weight apolipoprotein(a) isoforms and obesity in Italian women
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, Section of Internal Medicine, Vascular and Metabolic Diseases, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, University of Pavia, P le C Golgi, Italy
    Obes Res 12:1322-6. 2004
    ..The hypothesis of this study was to assess whether there are differences in the distribution of apo(a) phenotypes between obese patients and healthy controls...
  91. pmc Optimizing combination treatment in the management of type 2 diabetes
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Vasc Health Risk Manag 3:665-71. 2007
    ..The possible adverse effects derived from the association of different drug classes are also considered...
  92. ncbi request reprint Vascular remodeling and prothrombotic markers in subjects affected by familial combined hyperlipidemia and/or metabolic syndrome in primary prevention for cardiovascular disease
    Arrigo F G Cicero
    GC Descovich Atherosclerosis and Metabolic Disease Research Unit, D Campanacci Clinical Medicine and Applied Biotechnology Department, Alma Mater Studiorum University of Bologna, Bologna, Italy
    Endothelium 14:193-8. 2007
    ..However, the superposition of MS on FCH further increases the plasma level of these parameters. The prognostic value of this observation has to be evaluated...
  93. ncbi request reprint Different effect of psyllium and guar dietary supplementation on blood pressure control in hypertensive overweight patients: a six-month, randomized clinical trial
    Arrigo F G Cicero
    GC Descovich Atherosclerosis Research Centre, D Campanacci Clinical Medicine and Applied Biotechnology Dept, University of Bologna, Italy
    Clin Exp Hypertens 29:383-94. 2007
    ..In our study, six-month supplementation with psyllium fiber, but not with guar fiber nor standard diet, appears to significantly reduce both SBP and DBP in hypertensive overweight subjects...
  94. ncbi request reprint Prospects for the development of novel anti-hyperlipidemic drugs
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Italy
    Curr Opin Investig Drugs 7:826-33. 2006
    ....
  95. ncbi request reprint Matrix metalloproteinase 2 may be a marker of microangiopathy in children and adolescents with type 1 diabetes
    Giuseppe Derosa
    Diabetes Care 27:273-4. 2004
  96. ncbi request reprint Differential effects of lercanidipine and nifedipine GITS on plasma norepinephrine in chronic treatment of hypertension
    Roberto Fogari
    Centro Ipertensione e Fisiopatologia Cardiovascolare, Dipartimento di Medicina Interna e Terapia Medica, Clinica Medica II Università di Pavia, Pavia, Italy
    Am J Hypertens 16:596-9. 2003
    ....
  97. ncbi request reprint Comparison between metalloproteinases-2 and -9 in healthy subjects, diabetics, and subjects with acute coronary syndrome
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico S Matteo, Pavia, Italy
    Heart Vessels 22:361-70. 2007
    ..In conclusion, MMP-2, MMP-9, TIMP-1, and TIMP-2 plasma levels were higher in diabetic, ACS, and DACS patients, which may reflect abnormal extracellular matrix metabolism in diabetes and in acute coronary syndrome...
  98. ncbi request reprint Effect of oral chronic isoflavones supplementation on male rat sexual performances and sexual hormone plasma levels
    Arrigo F G Cicero
    Biomedical Sciences Department, Pharmacology Section, University of Modena and Reggio nell emilia, Modena, Italy
    Phytother Res 18:849-52. 2004
    ..No significant difference has been observed as regards FSH, progesterone, androstenedione plasma levels, either between groups or between baseline and study end. Slight differences were found regards LH and testosterone plasma level...
  99. ncbi request reprint Two-year statin therapy does not alter the progression of intima-media thickness in patients with type 2 diabetes without manifest cardio-vascular disease: response to Beishuizen et al
    Arrigo F G Cicero
    Diabetes Care 28:1262-3; author reply 1263-4. 2005