Research Topics
| M De MartinoSummaryCountry: Italy Publications
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Publications
Highly active antiretroviral therapy restores in vitro mitogen and antigen-specific T-lymphocyte responses in HIV-1 perinatally infected children despite virological failureM Peruzzi
Laboratory of Immunology, Department of Paediatrics, University of Florence, Italy
Clin Exp Immunol 128:365-71. 2002..It implies that a direct mechanism might be involved in the overall immune recovery under HAART...
Sweat testing in newborns positive to neonatal screening for cystic fibrosisG Taccetti
Meyer Pediatric Hospital, University of Florence, Via L Giordano 13, Florence 50132, Italy
Arch Dis Child Fetal Neonatal Ed 89:F463-4. 2004..There are no significant correlations between age at sweat testing and sweat chloride concentration or quantity of sweat collected...
Epidemiology of hospital admissions for chickenpox in children: an Italian multicentre study in the pre-vaccine eraS Marchetto
Department of Paediatrics, University of Florence, Florence, Italy
Acta Paediatr 96:1490-3. 2007..To describe the chickenpox complications in children in Italy...
Eyelash length in children with vernal keratoconjunctivitis: effect of treatment with cyclosporine eye dropsN Pucci
Allergy and Clinical Immunology Unit, Department of Pediatrics, University of Florence, Florence, Italy
Int J Immunopathol Pharmacol 20:595-9. 2007....
Loss of efficacy during long-term infliximab therapy for sight-threatening childhood uveitisG Simonini
Department of Paediatrics, Rheumatology Unit, Anna Meyer Children s Hospital and University of Florence, Italy
Rheumatology (Oxford) 47:1510-4. 2008..To describe efficacy and safety of infliximab in the treatment of childhood chronic uveitis during a long-term follow-up...
Interleukin-6 release by cultured peripheral blood mononuclear cells inversely correlates with height velocity, bone age, insulin-like growth factor-I, and insulin-like growth factor binding protein-3 serum levels in children with perinatal HIV-1 infectioM De Martino
Department of Pediatrics, University of Florence, Florence, I 50132, Italy
Clin Immunol 94:212-8. 2000..Growth-promoting strategies, including targeted anticytokine treatments, could be devised for such children...
Viral load and CD69 molecule expression on freshly isolated and cultured mitogen-stimulated lymphocytes of children with perinatal HIV-1 infectionM De Martino
Department of Medicine, Section of Paediatrics, University of Chieti, Chieti, Italy
Clin Exp Immunol 117:513-6. 1999..CD8+CD69+ (but not CD4+CD69+) lymphocyte proportion correlated with virologic course, and an impaired ability of CD8+ lymphocytes to express CD69 upon PHA stimulation preceded a virologic worsening...
TT virus infection in human immunodeficiency virus type 1 infected mothers and their infantsM De Martino
Department of Paediatrics, University of Florence, Florence, Italy
J Med Virol 61:347-51. 2000..TTV infection in HIV 1 infected women is prevalently related to intravenous drug user. The findings suggest that infants may acquire TTV at birth. Infection may persist without evident liver disease...
Reduction in mortality with availability of antiretroviral therapy for children with perinatal HIV-1 infection. Italian Register for HIV Infection in Children and the Italian National AIDS RegistryM De Martino
Department of Pediatrics, University of Florence, Via Luca Giordano 13, I 50132 Florence, Italy
JAMA 284:190-7. 2000..However, little information is available outside the setting of controlled trials on survival of perinatally HIV-infected children treated with antiretroviral therapy...
Allergen specific nasal challenge to latex in children with latex allergy: clinical and immunological evaluationR Bernardini
Pediatric Allergy and Pulmonology Center, Department of Pediatrics, University of Florence, Anna Meyer Children s Hospital, Via Luca Giordano 13, Florence, Italy
Int J Immunopathol Pharmacol 21:333-41. 2008..MFNS premedication before an ASNCL may prevent some immunological responses induced by ASNCL without clinical allergic modifications...
Onset of clinical signs in children with HIV-1 perinatal infection. Italian Register for HIV Infection in ChildrenL Galli
Department of Paediatrics, University of Florence, Italy
AIDS 9:455-61. 1995..Infection is shown to progress faster than in adults and in a different manner. Low birthweight, early decreased CD4+ cell counts, and early onset of signs are predictive of rapid progression...
Cost of varicella-related hospitalisations in an Italian paediatric hospital: comparison with possible vaccination expensesC Azzari
Paediatric Immunology Unit, Anna Meyer Children s Hospital and University of Florence, Florence, Italy
Curr Med Res Opin 23:2945-54. 2007....
Puberty in perinatal HIV-1 infection: a multicentre longitudinal study of 212 childrenM De Martino
Department of Paediatrics, University of Florence, Florence, Italy
AIDS 15:1527-34. 2001..Intervention could save much psychological distress, since associated linear growth failure can exacerbate adolescents' feelings of being different and unwell...
Restored antioxidant capacity parallels the immunologic and virologic improvement in children with perinatal human immunodeficiency virus infection receiving highly active antiretroviral therapyM De Martino
Department of Pediatrics, University of Florence, Florence, Italy
Clin Immunol 100:82-6. 2001..A positive feedback may be triggered since restored antioxidant capacity counterbalances the oxidative stress, which enhances lymphocyte apoptosis and HIV replication...
Macrophage migration inhibitory factor -173 polymorphism and risk of coronary alterations in children with Kawasaki diseaseG Simonini
Department of Paediatrics, Rheumatology Unit, A Meyer Children s Hospital, Florence, Italy
Clin Exp Rheumatol 27:1026-30. 2009..To investigate the possible relationship between MIF -173 polymorphism and susceptibility to, and severity of, Kawasaki disease (KD) in a cohort of Italian patients...
Vertical hepatitis C virus transmission is not related to mother-child class-1 HLA concordanceC Azzari
Department of Paediatrics, University of Florence, Anna Meyer Children s Hospital, Florence, Italy
Int J Immunopathol Pharmacol 20:827-31. 2007..30) and when only A and B alleles were evaluated (p=0.59). Mother-infant HLA concordance does not affect HCV vertical transmission...
Interferon-γ release assays for the diagnosis of Mycobacterium tuberculosis infection in children: a systematic review and meta-analysisE Chiappini
Department of Sciences for Woman and Child s Health, Anna Meyer Children s University Hospital Florence, University of Florence, Italy
Int J Immunopathol Pharmacol 25:557-64. 2012..95 (95% CI:0.93- 0.97) and 0.96 (95% CI:0.93-1.00), respectively. Pooled TST specificity was significantly lower 0.83 (95% CI:0.74-0.92). IGRA performance in children showed no better sensitivity than TST, but higher specificity...
SEN virus co-infection among HCV-RNA-positive mothers, risk of transmission to the offspring and outcome of child infection during a 1-year follow-upM Moriondo
Department of Paediatrics, University of Florence, Italy and Paediatric Hospital Anna Meyer, Florence, Italy
J Viral Hepat 14:355-9. 2007..Persistence of SENV infection was demonstrated in 100% of infected children after 1-year follow-up, but none had clinical evidence of liver disease...
Immune recovery following antineoplastic chemotherapy and highly active antiretroviral therapy (HAART) in a child with HIV-1 infection previously unresponsive to HAARTL Galli
Division of Paediatric Infectious Diseases, University of Florence, Anna Meyer Children's Hospital, Florence, Italy
Int J Immunopathol Pharmacol 19:919-22. 2006....
Different kinetics of immunologic recovery using nelfinavir or lopinavir/ritonavir-based regimens in children with perinatal HIV-1 infectionM De Luca
Department of Paediatrics, University of Florence, Florence, Italy
Int J Immunopathol Pharmacol 18:729-35. 2005....
Thyroid function in children with perinatal human immunodeficiency virus type 1 infectionF Chiarelli
Department of Medicine, University of Chieti, Italy
Thyroid 10:499-505. 2000..To study thyroid function in children with perinatal HIV-1 infection retrospectively and determine whether thyroid abnormalities are correlated with clinical condition, disease progression, immunological impairment, and viral load...
Hospitalization rates for complicated and uncomplicated chickenpox in a poorly vaccined pediatric populationF Bonsignori
Department of Paediatrics, University of Florence, Anna Meyer Children s Hospital, Via Luca Giordano, 13, I 50132, Florence, Italy
Infection 35:444-50. 2007..A retrospective study was conducted to provide epidemiological data on hospitalization for complicated and uncomplicated chickenpox in a pediatric population...
Pertussis immunization in HIV-1-infected infants: a model to assess the effects of repeated T cell-dependent antigen administrations on HIV-1 progression. Italian Register for HIV infection in childrenP A Tovo
Department of Pediatrics, University of Turin, Italy
Vaccine 18:1203-9. 2000..The lack of a significant impact on clinical and immunological deterioration by the repeated administrations of a T cell-dependent vaccine endorses the current recommendations for routine immunizations in HIV-1-infected children...
Systemic treatment of rhinosinusitis in childrenE Novembre
Allergy and Clinical Immunology Unit, Anna Meyer Children s Hospital, Department of Pediatrics, University of Florence, Italy
Pediatr Allergy Immunol 18:56-61. 2007..To date, there is no good evidence from randomized controlled studies to support the use of any of these agents in the treatment of this disease in either children or adults...
Diagnostic value of three different latex extractsR Bernardini
Pediatric Allergy and Pulmonology Center, Department of Pediatrics, Anna Meyer Children Hospital, University of Florence, Italy
Int J Immunopathol Pharmacol 20:393-400. 2007..This study showed that SL extract is able to express the best in vitro and in vivo diagnostic potential. Thus, its use should be preferred for the diagnosis of patients affected by latex allergy...
Birth weight for gestational age centiles for Italian neonatesF Festini
Regional Cystic Fibrosis Center of Tuscany, Division of Paediatric Infectious Diseases, Meyer Pediatric Hospital, Department of Pediatrics, University of Florence, Via Luca Giordano 12, 50132 Florence, Italy
J Matern Fetal Neonatal Med 15:411-7. 2004..CONCLUSIONS: The large size of the examined population allows us to provide up-to-date, reliable BW for GA centiles for Italian newborns, especially for lower GAs...
Autoimmunity: basic mechanisms and implications in endocrine diseases. Part IIS Ballotti
Department of Paediatrics, Anna Meyer Children's Hospital, University of Florence, Florence, Italy
Horm Res 66:142-52. 2006..In addition, autoimmunity does not always have pathological consequences, but may exert a protective function, as suggested by several observations on the beneficial role of autoreactive T cells in central nervous system injury...
The infections of the upper respiratory tract in childrenF Bonsignori
Department of Paediatrics, University of Florence, Anna Meyer University Children s Hospital, Florence, Italy
Int J Immunopathol Pharmacol 23:16-9. 2010..The first choice treatment in European countries still remains amoxicillin or amoxicillin/clavulanate...
CD4+CD25+Foxp3+ T regulatory cells are not involved in oral desensitizationF Mori
Allergy and Clinical Immunological Unit, A Meyer Children Hospital, Department of Pediatrics, University of Florence, Italy
Int J Immunopathol Pharmacol 23:359-61. 2010....
Respiratory impedance and bronchodilator response in healthy Italian preschool childrenC Calogero
Section of Respiratory Medicine, Department of Paediatrics, University of Florence, Anna Meyer University Hospital for Children, Florence, Italy
Pediatr Pulmonol 45:1086-94. 2010..To define normal values for respiratory resistance (R(rs)) and reactance (X(rs)) and bronchodilator response (BDR) in a population of healthy Italian preschool children using a commercially available forced oscillation device...
Neonatal suppurative parotitis: a study of five casesG Sabatino
Neonatal Intensive Care Unit, University of Chieti, Italy
Eur J Pediatr 158:312-4. 1999..Antimicrobial therapy was effective in all cases; surgery was not required. CONCLUSION: Although neonatal suppurative parotitis is now uncommon in the newborn, it cannot be considered a "vanishing disease"...
Cytokine expression in CD3+ cells in an infant with food protein-induced enterocolitis syndrome (FPIES): case reportF Mori
Allergy and Clinical Immunology Unit, Department of Pediatrics, Meyer Children Hospital, University of Florence, 50122 Florence, Italy
Clin Dev Immunol 2009:679381. 2009..On the other hand, T cell-derived IL-10 may play a role in the acquisition of immunotolerance by regulating the Th1 and Th2 responses...
Approaches to quality of control in diabetes careF Chiarelli
Department of Pediatrics, University of Chieti, Italy
Horm Res 50:41-7. 1998....
Interferon-gamma release assays for the diagnosis of Mycobacterium tuberculosis infection in children: a literature reviewE Chiappini
Department of Science for Woman and Childs Health, University of Florence, Italy
Int J Immunopathol Pharmacol 25:335-43. 2012..Combined use of TST/IGRA may increase diagnostic sensitivity but interpretation of discordant results remains a challenging issue...
Intracardiac left atrial tuberculoma in an eleven-month-old infant: case reportM Cantinotti
Department of Sciences for Woman and Child s Health, University of Florence, Anna Meyer Children s University Hospital, Florence, Italy
BMC Infect Dis 11:359. 2011..Involvement of other part of the heart is unusual and descriptions in the pediatric literature are confined to few case reports regarding mainly myocardial tuberculosis...
Recurrent respiratory infections: why not talking about it any more?E Nencioni
Department of Pediatrics, University of Florence, Italy
Minerva Pediatr 60:1411-6. 2008..Use of anti-cough syrups should be avoided. Nasal lavage with saline serum and the blowing are the only justified interventions. Adenoidectomy and tonsillectomy should be planned only in conditions included in validated guidelines...
Inhibition of natural killer cell cytotoxicity and interferon gamma production by the envelope protein of HIV and prevention by vasoactive intestinal peptideM Peruzzi
Department of Pediatrics, University of Florence, Italy
AIDS Res Hum Retroviruses 16:1067-73. 2000....
Therapeutic management of bacterial meningitis in children: a systematic review and comparison of published guidelines from a European perspectiveM De Gaudio
Department of Pediatrics, University of Florence, Florence, Italy
J Chemother 22:226-37. 2010..further studies and expert consensus are required to establish the best management of bacterial meningitis in the european setting based on the most recent epidemiological data on resistance rates...
Natural killer cell deficiencies in a consecutive series of children with herpetic encephalitisF Almerigogna
Department of Internal Medicine, University of Florence, Italy
Int J Immunopathol Pharmacol 24:231-8. 2011..These findings suggest a role for NK cell deficiencies as a predisposing factor for increased susceptibility and severe course of disease in these patients...
Increased Na+/Li+ countertransport activity may help to identify type 1 diabetic adolescents and young adults at risk for developing persistent microalbuminuriaF Chiarelli
Department of Medicine, University of Chieti, Italy
Diabetes Care 22:1158-64. 1999....
The child with recurrent respiratory infections: normal or not?M De Martino
Department of Paediatrics, University of Florence, Anna Meyer Children s Hospital, Florence, Italy
Pediatr Allergy Immunol 18:13-8. 2007..When RRI diagnosis has been formulated, removal of environmental risk factors (i.e. precocious day-care attendance, smoking in the household) must first be suggested...
Comparison between pulse oximetry and transthoracic impedance alarm traces during home monitoringN Nassi
Department of Pediatrics, University of Florence, Anna Meyer Children s University Hospital, Florence, Italy
Arch Dis Child 93:126-32. 2008..To compare transthoracic impedance (TTI/ECG) and pulse oximetry alarm traces detected during home monitoring in infants at risk of apnoea, bradycardia and hypoxaemia...
Antimicrobial susceptibility and synergistic activity of meropenem against Gram-negative non-fermentative bacteria isolated from cystic fibrosis patientsS Campana
Department of Pediatrics, Anna Meyer Children s Hospital, University of Florence, Florence, Italy
J Chemother 15:551-4. 2003..Therefore in vitro methods for testing double antibiotic combinations are mandatory...
Molecular epidemiology of meticillin-resistant Staphylococcus aureus in Italian cystic fibrosis patients: a national overviewP Cocchi
Department of Sciences for Woman and Child s Health, University of Florence, Florence, Italy
J Cyst Fibros 10:407-11. 2011..The aim of this multicentre study was to analyse MRSA strains isolated from CF patients attending nine Italian CF care centres during a two-year period (2004-2005). All CF patients infected by MRSA were included...
Cross-reactivity between IgE-binding proteins from Anisakis simplex and Dermatophagoides pteronyssinusR Bernardini
Pediatric Allergy and Pulmonary Center, Anna Meyer Children s Hospital, Department of Pediatrics, University of Florence, Italy
Int J Immunopathol Pharmacol 18:671-5. 2005..The results show that 1) cross-reactive components between Dp and As are some proteins with a mw ranging approximately from 35 to 50 kD and with a mw > than 100 kD, and 2) tr is not involved in cross-reactivity between As and Dp...
Sex ratio at birth among Chinese babies born in Italy is lower than in ChinaF Festini
Cystic Fibrosis Centre, Meyer Paediatric Hospital, University of Florence, Italy
J Epidemiol Community Health 57:967-8. 2003
Autoimmunity: basic mechanisms and implications in endocrine diseases. Part IS Ballotti
Department of Paediatrics, Anna Meyer Children's Hospital, University of Florence, Florence, Italy
Horm Res 66:132-41. 2006..These events may be involved in the pathogenesis of endocrine diseases at several levels...
Macroangiopathy in adults and children with diabetes: risk factors (part 2)D Di Marzio
Department of Pediatrics, University of Chieti, Italy
Horm Metab Res 38:706-20. 2006....
[Incidence of nosocomial rotavirus infections in a pediatric hospital over a 3-year period]K P Biermann
Azienda Ospedaliero Universitaria Meyer, Florence, Italy
Minerva Pediatr 58:477-82. 2006..Infection prevention activities should involve mothers and families of hospitalized children, as they perform on them a great deal of basic care and hygiene activities which are at risk for hospital cross-infections...
