Claudio De Felice

Summary

Country: Italy

Publications

  1. ncbi request reprint Predictive value of skin color for illness severity in the high-risk newborn
    Claudio De Felice
    Department of Pediatrics, Obstetrics and Reproduction, University of Siena, Italy
    Pediatr Res 51:100-5. 2002
  2. pmc Abnormal oral mucosal light reflectance: a new clinical marker of high risk for colorectal cancer
    C De Felice
    Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Policlinico Le Scotte, Viale M Bracci, 16 I 53100 Siena, Italy
    Gut 55:1436-9. 2006
  3. ncbi request reprint Oral mucosal microvascular abnormalities: an early marker of bronchopulmonary dysplasia
    Claudio De Felice
    Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, University of Siena, I 53100 Siena, Italy
    Pediatr Res 56:927-31. 2004
  4. doi request reprint Recurrent otitis media with effusion in preterm infants with histologic chorioamnionitis--a 3 years follow-up study
    Claudio De Felice
    Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese Siena, Italy
    Early Hum Dev 84:667-71. 2008
  5. doi request reprint Maternal pulse oximetry perfusion index as a predictor of early adverse respiratory neonatal outcome after elective cesarean delivery
    Claudio De Felice
    Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Policlinico Le Scotte, Siena, Italy
    Pediatr Crit Care Med 9:203-8. 2008
  6. doi request reprint Early activation of the hypothalamic-pituitary-adrenal-axis in very-low-birth-weight infants with small thymus at birth
    C De Felice
    Neonatal Intensive Care Unit, Italy
    J Matern Fetal Neonatal Med 21:251-4. 2008
  7. ncbi request reprint Subclinical chorioamnionitis: an unrecognised risk factor for severe pulmonary haemorrhage in extremely low birth weight infants
    Claudio De Felice
    Division of Neonatology, Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Le Scotte General Hospital, Viale M Bracci 16, 53100 Siena, Italy
    Eur J Pediatr 164:111-2. 2005
  8. ncbi request reprint Histologic chorioamnionitis and severity of illness in very low birth weight newborns
    Claudio De Felice
    Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Policlinico Le Scotte, Viale M Bracci 16, I 53100 Siena, Italy
    Pediatr Crit Care Med 6:298-302. 2005
  9. pmc Fordyce granules and hereditary non-polyposis colorectal cancer syndrome
    C De Felice
    Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Policlinico Le Scotte, Viale M Bracci, 16 I 53100 Siena, Italy
    Gut 54:1279-82. 2005
  10. ncbi request reprint A new phenotypical variant of intrauterine growth restriction?
    Claudio DeFelice
    Neonatal Intensive Care Unit, Division of Neonatology, Azienda Ospedaliera Universitaria Senese Le Scotte Hospital, Viale M Bracci 16, 53100 Siena, Italy
    Pediatrics 119:e983-90. 2007

Collaborators

Detail Information

Publications76

  1. ncbi request reprint Predictive value of skin color for illness severity in the high-risk newborn
    Claudio De Felice
    Department of Pediatrics, Obstetrics and Reproduction, University of Siena, Italy
    Pediatr Res 51:100-5. 2002
    ..7; 95% confidence interval, 6.4 to 33.8). Our findings indicate that skin color reflects clinical severity in the newborn and that skin colorimetry can accurately identify higher risk infants...
  2. pmc Abnormal oral mucosal light reflectance: a new clinical marker of high risk for colorectal cancer
    C De Felice
    Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Policlinico Le Scotte, Viale M Bracci, 16 I 53100 Siena, Italy
    Gut 55:1436-9. 2006
    ..In the present study, the value of oral mucosal light reflectance in identifying hereditary non-polyposis colorectal cancer (HNPCC) carriers was investigated...
  3. ncbi request reprint Oral mucosal microvascular abnormalities: an early marker of bronchopulmonary dysplasia
    Claudio De Felice
    Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, University of Siena, I 53100 Siena, Italy
    Pediatr Res 56:927-31. 2004
    ..0001). Our findings provide a new early clinical sign in BPD and stress the importance of an early disorder in the oral mucosal vascularization process in the disease pathogenesis...
  4. doi request reprint Recurrent otitis media with effusion in preterm infants with histologic chorioamnionitis--a 3 years follow-up study
    Claudio De Felice
    Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese Siena, Italy
    Early Hum Dev 84:667-71. 2008
    ..Here, we tested the hypothesis of an association between recurrent OME during the first 3 years of life and HCA in very low birth weight (VLBW) infants...
  5. doi request reprint Maternal pulse oximetry perfusion index as a predictor of early adverse respiratory neonatal outcome after elective cesarean delivery
    Claudio De Felice
    Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Policlinico Le Scotte, Siena, Italy
    Pediatr Crit Care Med 9:203-8. 2008
    ..Here, we prospectively tested the hypothesis that a low maternal perfusion index at the baseline phase (i.e., preanesthesia) of the elective cesarean section is a predictor of early adverse neonatal respiratory outcome...
  6. doi request reprint Early activation of the hypothalamic-pituitary-adrenal-axis in very-low-birth-weight infants with small thymus at birth
    C De Felice
    Neonatal Intensive Care Unit, Italy
    J Matern Fetal Neonatal Med 21:251-4. 2008
    ..However, the mechanisms of thymic involution remain to be clarified. Here, we tested the hypothesis that an activation of the hypothalamic-pituitary-adrenal (HPA) axis occurs in VLBW infants with acute thymic involution at birth...
  7. ncbi request reprint Subclinical chorioamnionitis: an unrecognised risk factor for severe pulmonary haemorrhage in extremely low birth weight infants
    Claudio De Felice
    Division of Neonatology, Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Le Scotte General Hospital, Viale M Bracci 16, 53100 Siena, Italy
    Eur J Pediatr 164:111-2. 2005
  8. ncbi request reprint Histologic chorioamnionitis and severity of illness in very low birth weight newborns
    Claudio De Felice
    Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Policlinico Le Scotte, Viale M Bracci 16, I 53100 Siena, Italy
    Pediatr Crit Care Med 6:298-302. 2005
    ..In this study, the relationships among HCA, initial illness severity, and neonatal outcomes were analyzed in very low birth weight (VLBW) newborns admitted to the neonatal intensive care unit...
  9. pmc Fordyce granules and hereditary non-polyposis colorectal cancer syndrome
    C De Felice
    Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Policlinico Le Scotte, Viale M Bracci, 16 I 53100 Siena, Italy
    Gut 54:1279-82. 2005
    ..Early identification of gene carriers is essential to reduce cancer incidence and overall mortality...
  10. ncbi request reprint A new phenotypical variant of intrauterine growth restriction?
    Claudio DeFelice
    Neonatal Intensive Care Unit, Division of Neonatology, Azienda Ospedaliera Universitaria Senese Le Scotte Hospital, Viale M Bracci 16, 53100 Siena, Italy
    Pediatrics 119:e983-90. 2007
    ..A link between intrauterine growth restriction and major adult-onset diseases has been reported. In this study we observed a series of hitherto-unrecognized clinical features in a population of children with intrauterine growth restriction...
  11. ncbi request reprint Skin reflectance changes in preterm infants with patent ductus arteriosus
    Claudio De Felice
    Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Policlinico Le Scotte, Viale M Bracci 16, Siena I 53100, Italy
    Early Hum Dev 78:45-51. 2004
    ..Patent ductus arteriosus (PDA) is a common complication in preterm infants. While two-dimensional echocardiography is the method of choice for diagnosing a PDA, clinical signs are known to be of limited value...
  12. ncbi request reprint Small thymus at birth: a predictive radiographic sign of bronchopulmonary dysplasia
    Claudio De Felice
    Department of Pediatrics, Obstetrics and Reproduction, University of Siena, Italy
    Pediatrics 110:386-8. 2002
    ..We tested the hypothesis that a small thymus detected at birth on the routine chest radiograph is a predictor of BPD in VLBW infants...
  13. pmc Abnormal vascular network complexity: a new phenotypic marker in hereditary non-polyposis colorectal cancer syndrome
    C De Felice
    Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Siena, Italy
    Gut 52:1764-7. 2003
    ..HNPCC results from dominantly inherited germline mutations in mismatch repair (MMR) genes, leading to genomic instability and cancer. No predictive physical signs of HNPCC are available to date...
  14. ncbi request reprint The pulse oximeter perfusion index as a predictor for high illness severity in neonates
    Claudio De Felice
    Dipartimento di Pediatria Ostetricia e Medicina della Riproduzione, Azienda Ospedaliera Senese, Viale M Bracci 16, 53100 Siena, Italy
    Eur J Pediatr 161:561-2. 2002
  15. ncbi request reprint Abnormal oral mucosal light reflectance in bronchopulmonary dysplasia
    Claudio De Felice
    Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Siena, Italy
    Early Hum Dev 82:273-8. 2006
    ..Here, we aimed to assess the potential value of light reflectance on the oral mucosa in detecting infants who will develop BPD...
  16. pmc Isoprostanes and 4-hydroxy-2-nonenal: markers or mediators of disease? Focus on Rett syndrome as a model of autism spectrum disorder
    Cinzia Signorini
    Department of Molecular and Developmental Medicine, University of Siena, I 53100 Siena, Italy
    Oxid Med Cell Longev 2013:343824. 2013
    ..In our experience, Rett syndrome offers a unique setting for physicians, biologists, and chemists to explore the borders of the lipid mediators concept. ..
  17. doi request reprint Subclinical myocardial dysfunction in Rett syndrome
    Claudio De Felice
    Neonatal Intensive Care Unit, University General Hospital, Azienda Ospedaliera Universitaria Senese, Viale M Bracci 16, Siena, Italy
    Eur Heart J Cardiovasc Imaging 13:339-45. 2012
    ..Besides, increased oxidative stress markers (OS) have been found in RTT. We hypothesized that (i) RTT patients present a subclinical biventricular dysfunction and (ii) the myocardial dysfunction correlate with OS...
  18. doi request reprint Morphological changes and oxidative damage in Rett Syndrome erythrocytes
    Lucia Ciccoli
    Department of Pathophysiology, Experimental Medicine and Public Health, University of Siena, Siena, Italy
    Biochim Biophys Acta 1820:511-20. 2012
    ..Here, RBCs shape was evaluated in RTT patients and healthy subjects as a function of OS markers, blood oxygenation, pulmonary gas exchange, and cardio-respiratory parameters...
  19. ncbi request reprint Abnormal oral mucosal light reflectance in achondroplasia
    Claudio De Felice
    Hospital based Neonatologist and Clinical Researcher, Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Italy
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:748-52. 2006
    ..4% specificity. These findings indicate the presence of previously unrecognized oral mucosal reflectance abnormalities in unaffected ACH parents of ACH children...
  20. doi request reprint F₄-neuroprostanes mediate neurological severity in Rett syndrome
    Cinzia Signorini
    Department of Pathophysiology, Experimental Medicine and Public Health, University of Siena, Siena, Italy
    Clin Chim Acta 412:1399-406. 2011
    ..In addition, we investigate on the impact of ω-3 polyunsaturated fatty acids (ω-3 PUFAs) supplementation on F₄-NeuroPs levels...
  21. doi request reprint Oxidative stress in Rett syndrome: natural history, genotype, and variants
    Silvia Leoncini
    Department of Pathophysiology, Experimental Medicine and Public Health, University of Siena, and Neonatal Intensive Care Unit, University Hospital, Azienda Ospedaliera Senese, Siena, Italy
    Redox Rep 16:145-53. 2011
    ....
  22. doi request reprint Non-protein-bound iron and 4-hydroxynonenal protein adducts in classic autism
    Alessandra Pecorelli
    Department of Pathophysiology, Experimental Medicine and Public Health, University of Siena, Viale M Bracci 16, Siena, Italy
    Brain Dev 35:146-54. 2013
    ..Increased levels of NPBI could contribute to lipid peroxidation and, consequently, to increased plasma and erythrocyte membranes 4-HNE PAs thus amplifying the oxidative damage, potentially contributing to the autistic phenotype...
  23. ncbi request reprint Early dynamic changes in pulse oximetry signals in preterm newborns with histologic chorioamnionitis
    Claudio De Felice
    Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Policlinico Le Scotte, Siena, Italy
    Pediatr Crit Care Med 7:138-42. 2006
    ..Increasing evidence indicates myocardial dysfunctions in affected fetuses and newborns. We sought to assess the value of nonlinear dynamics from pulse oximetry signals in identifying affected newborns...
  24. ncbi request reprint Abnormal oral mucosal light reflectance in infantile hypertrophic pyloric stenosis
    Stefano Parrini
    Department of Odontostomatologic Sciences, University of Siena, Siena, Italy
    J Pediatr Gastroenterol Nutr 39:53-5. 2004
    ..Phenotypical markers of IHPS, such as hypoplasia or agenesis of the inferior labial frenulum, have been described. The authors tested the hypothesis that IHPS is associated with abnormal reflectance of the oral mucosa...
  25. ncbi request reprint Oral mucosa spectrophotometric changes in healthy parents of patients with Down syndrome
    Giuseppe Latini
    Division of Neonatology, Ospedale Perrino, Brindisi, Italy
    Prenat Diagn 24:685-7. 2004
    ..To date, no phenotypical markers in the parents of DS offspring are known. Here, we tested the value of oral mucosal reflectance spectrophotometry in identifying unaffected parents of DS patients (free trisomy 21)...
  26. doi request reprint Unrecognized lung disease in classic Rett syndrome: a physiologic and high-resolution CT imaging study
    Claudio De Felice
    Neonatal Intensive Care Unit, University Hospital, Azienda Ospedaliera Universitaria Senese of Siena, Siena, Italy
    Chest 138:386-92. 2010
    ..The aim of the present study was to determine if there are RS-associated pulmonary abnormalities...
  27. doi request reprint Subclinical inflammatory status in Rett syndrome
    Alessio Cortelazzo
    Child Neuropsychiatry Unit, University Hospital Azienda Ospedaliera Universitaria Senese AOUS, Viale M Bracci 16, 53100 Siena, Italy Department of Medical Biotechnologies, University of Siena, Via A Moro 2, 53100 Siena, Italy
    Mediators Inflamm 2014:480980. 2014
    ..Our findings reveal for the first time the presence of a subclinical chronic inflammatory status related to the "pseudo-autistic" phase of RTT, which is related to the severity carried by the MECP2 gene mutation. ..
  28. doi request reprint Survival rate and prevalence of bronchopulmonary dysplasia in extremely low birth weight infants
    Giuseppe Latini
    Division of Neonatology, Perrino Hospital, Brindisi, Italy Clinical Physiology Institute IFC CNR, National Research Council of Italy, Lecce Section, Italy
    Early Hum Dev 89:S69-73. 2013
    ..The increasing prevalence of BPD over the decades has been suggested to be related to the increased survival of extremely low birthweight infants...
  29. doi request reprint The role of oxidative stress in Rett syndrome: an overview
    Claudio De Felice
    Neonatal Intensive Care Unit University Hospital, Azienda Ospedaliera Universitaria Senese of Siena, Siena, Italy
    Ann N Y Acad Sci 1259:121-35. 2012
    ..Further efforts in the near future are needed for investigating the yet unexplored "black box" between the MeCP2 gene mutation and subsequent OS derangement...
  30. pmc Partial rescue of Rett syndrome by ω-3 polyunsaturated fatty acids (PUFAs) oil
    Claudio De Felice
    Neonatal Intensive Care Unit, University Hospital Azienda Ospedaliera Universitaria Senese AOUS of Siena, S M Le Scotte General Hospital, Viale M Bracci, 16, 53100, Siena, Italy
    Genes Nutr 7:447-58. 2012
    ..For the first time, these findings strongly suggest that a dietary intervention in this genetic disease at an early stage of its natural history can lead to a partial clinical and biochemical rescue...
  31. pmc F2-dihomo-isoprostanes as potential early biomarkers of lipid oxidative damage in Rett syndrome
    Claudio De Felice
    Neonatal Intensive Care Unit, University Hospital, Azienda Ospedaliera Universitaria Senese, Siena, Italy
    J Lipid Res 52:2287-97. 2011
    ....
  32. ncbi request reprint Universal neonatal hearing screening: the Siena (Italy) experience on 19,700 newborns
    Bruno De Capua
    U O S Audiologia Clinica, Neonatal Intensive Care Unit, D A I Materno Infantile, Azienda Ospedaliera Universitaria Senese, Policlinico Santa Maria alle Scotte, Viale M Bracci 16, I 53100 Siena, Italy
    Early Hum Dev 83:601-6. 2007
    ..As 33-50% of all congenital HLs cannot be detected in a selective hearing risk, use of universal neonatal hearing screening (UNHS) programs is expanding...
  33. ncbi request reprint Abnormal oral vascular network pattern geometry: a new clinical sign of down syndrome
    Giuseppe Latini
    Division of Neonatology, Perrino Hospital, Brindisi, Clinical Physiology Institute, National Research Council of Italy IFC CNR, Lecce Section, Italy
    J Pediatr 148:132-7. 2006
    ..0006) for the oral vascular networks of patients (n = 14) and their unaffected parents. This newly recognized sign may provide a useful phenotypical marker for identifying couples potentially at risk for offspring with Down syndrome...
  34. ncbi request reprint Early postnatal skin colour changes in term newborns with subclinical histological chorioamnionitis
    Claudio De Felice
    Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Siena, Italy
    Eur J Pediatr 163:550-4. 2004
    ..012), Neonatal Acute Physiology-Perinatal Extension (P<0.0001) and Neonatal Therapeutic Intervention Scoring System (P<0.0001) scores than the chorioamnionitis-negative infants...
  35. ncbi request reprint Prolonged fetal bradycardia as the presenting clinical sign in Streptococcus agalactiae chorioamnionitis
    Giuseppe Presta
    Division of Neonatology, Perrino Hospital, Brindisi, Italy
    J Perinat Med 32:535-7. 2004
    ..We report a case of a 37 weeks' gestation infant with severe birth asphyxia, status epilepticus and GBS chorioamnionitis, in which a prolonged fetal bradycardia was the only prenatal clinical sign...
  36. doi request reprint Effects of ω-3 PUFAs supplementation on myocardial function and oxidative stress markers in typical Rett syndrome
    Silvia Maffei
    Department of Cardiology, University Hospital Azienda Ospedaliera Universitaria Senese AOUS, Viale M Bracci 16, 53100 Siena, Italy
    Mediators Inflamm 2014:983178. 2014
    ..Our data indicate that ω-3 PUFAs are able to improve the biventricular myocardial systolic function in RTT and that this functional gain is partially mediated through a regulation of the redox balance...
  37. doi request reprint Erythrocyte shape abnormalities, membrane oxidative damage, and β-actin alterations: an unrecognized triad in classical autism
    Lucia Ciccoli
    Department of Molecular and Developmental Medicine, University of Siena, Via A Moro 2, 53100 Siena, Italy
    Mediators Inflamm 2013:432616. 2013
    ....
  38. doi request reprint Beta-actin deficiency with oxidative posttranslational modifications in rett syndrome erythrocytes: insights into an altered cytoskeletal organization
    Alessio Cortelazzo
    Department of Medical Biotechnologies, University of Siena, Siena, Italy Child Neuropsychiatry Unit, University Hospital, Azienda Ospedaliera Universitaria Senese AOUS, Siena, Italy
    PLoS ONE 9:e93181. 2014
    ..Our findings demonstrate, for the first time, a beta-actin down-regulation and oxidative PTMs for RBCs of RTT patients, thus indicating an altered cytoskeletal organization. ..
  39. pmc Revealing the complexity of a monogenic disease: rett syndrome exome sequencing
    Elisa Grillo
    Medical Genetics, University of Siena, Siena, Italy
    PLoS ONE 8:e56599. 2013
    ..Most importantly, we demonstrated that monogenic diseases may be more complex than previously thought...
  40. doi request reprint F2-Isoprostanes in soft oral tissues and degree of oral disability after mandibular third molar surgery
    Stefano Parrini
    Tuscan School of Dental Medicine, University of Siena, Policlinico Le Scotte Viale M, Bracci, 16, I 53100 Siena, Italy
    Oral Surg Oral Med Oral Pathol Oral Radiol 114:344-9. 2012
    ..The aim of this study was to test the value of F(2)-isoprostane (F(2)-IsoP) levels in the pericoronal gingiva as a potential predictor of oral disability after mandibular third molar (M3M) surgery...
  41. ncbi request reprint Abnormal oral vascular network geometric complexity in Ehlers-Danlos syndrome
    Claudio De Felice
    Hospital based Neonatologist and Clinical Researcher, Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Siena, Italy
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 98:429-34. 2004
    ..0001) than controls. These findings indicate the presence of a previously unrecognized microvascular network abnormality on the oral mucosa in EDS patients, and provide an additional phenotypical marker for the condition...
  42. doi request reprint Increased levels of 4HNE-protein plasma adducts in Rett syndrome
    Alessandra Pecorelli
    Department of Pathophysiology, Experimental Medicine and Public Health, University of Siena, Siena, Via Aldo Moro 2, 53100 Siena, Italy
    Clin Biochem 44:368-71. 2011
    ..Increased oxidative stress (OS) has been documented in MeCP2-RTT patients. Here, we evaluated the levels of 4-hydroxynonenal plasma protein adducts (4HNE-PAs) in MeCP2-, CDKL5-, and FOXG1-RTT and in their clinical variants...
  43. doi request reprint Di-(2-ethylhexyl)phthalate leakage and color changes in endotracheal tubes after application in high-risk newborns
    Giuseppe Latini
    Division of Neonatology, A Perrino Hospital, Brindisi, Italy
    Neonatology 95:317-23. 2009
    ..Polyvinylchloride (PVC) is often adopted for making medical devices...
  44. doi request reprint Lactational exposure to phthalates in Southern Italy
    Giuseppe Latini
    Division of Neonatology, Perrino Hospital, Brindisi, Italy
    Environ Int 35:236-9. 2009
    ..Infants are considered to represent a population at increased risk, as they are exposed early in life to several different sources of exposure to phthalates...
  45. ncbi request reprint Abnormal oral mucosal light reflectance: a new clinical sign of Ehlers-Danlos syndrome
    Stefano Parrini
    Department of Odontostomatological Sciences, University of Siena, Italy
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97:335-8. 2004
    ..51% at the 400 nm wavelength identified the EDS patients with 100% sensitivity and 100% specificity. These findings indicate that an abnormal oral mucosal reflectance is a previously unrecognized clinical marker of EDS...
  46. ncbi request reprint Transient hypothyroxinemia of prematurity and histological chorioamnionitis
    Claudio De Felice
    Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Italy
    J Perinat Med 33:514-8. 2005
    ..Transient hypothyroxinaemia of prematurity (THOP) is a common condition of preterm infants whose causes remain unclear. We tested the hypothesis that THOP is associated with histological chorioamnionitis (HCA)...
  47. doi request reprint Genes related to mitochondrial functions, protein degradation, and chromatin folding are differentially expressed in lymphomonocytes of Rett syndrome patients
    Alessandra Pecorelli
    Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy Child Neuropsychiatry Unit, University Hospital, Azienda Ospedaliera Universitaria Senese, 53100 Siena, Italy
    Mediators Inflamm 2013:137629. 2013
    ..In conclusion, these findings suggest that mitochondrial-ATP-proteasome functions are likely to be involved in RTT clinical features. ..
  48. pmc Effects of ω -3 Polyunsaturated Fatty Acids on Plasma Proteome in Rett Syndrome
    Claudio De Felice
    Neonatal Intensive Care Unit, University Hospital Azienda Ospedaliera Universitaria Senese AOUS, Viale M Bracci 16, 53100 Siena, Italy
    Mediators Inflamm 2013:723269. 2013
    ..3 PUFAs have a major impact on the modulation of the APR in RTT, thus providing new insights into the role of inflammation in autistic disorders and paving the way for novel therapeutic strategies. ..
  49. doi request reprint First day of life reference values for pleth variability index in spontaneously breathing term newborns
    Giuseppe Latini
    Division of Neonatology, A Perrino Hospital, Brindisi, Italy
    Neonatology 101:179-82. 2012
    ..The plethysmographic variability index (PVI) is a measure of the dynamic change in PI occurring during a complete respiratory cycle...
  50. doi request reprint Determinants of nosocomial infection in 6 neonatal intensive care units: an Italian multicenter prospective cohort study
    Cinzia Auriti
    Neonatal Intensive Care Unit, Bambino Gesu Children s Hospital, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Rome, Italy
    Infect Control Hosp Epidemiol 31:926-33. 2010
    ..Nosocomial infections are still a major cause of morbidity and mortality among neonates admitted to neonatal intensive care units (NICUs)...
  51. ncbi request reprint Plasticizers, infant nutrition and reproductive health
    Giuseppe Latini
    Division of Neonatology, Ospedale A Perrino, s s 7 per Mesagne, 72100 Brindisi, Italy
    Reprod Toxicol 19:27-33. 2004
    ..Here, we report a review on dietary phthalate exposure in babies...
  52. ncbi request reprint Evaluating illness severity for very low birth weight infants: CRIB or CRIB-II?
    Claudio De Felice
    Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Siena, Italy
    J Matern Fetal Neonatal Med 17:257-60. 2005
    ..Aim. The accuracy values of CRIB and CRIB-II scores in predicting in-hospital mortality were compared in a tertiary level, minimal intubation policy NICU setting...
  53. doi request reprint Systematic underestimation of oxygen delivery in ventilated preterm infants
    Claudio De Felice
    Neonatal Intensive Care Unit, Policlinico S Maria alle Scotte, Azienda Ospedaliera Universitaria Senese, Siena, Italy claudiodefelix hotmail it
    Neonatology 98:18-22. 2010
    ..To date, the equivalence between set and delivered oxygen (O(2)) in ventilated preterm infants has not been rigorously studied...
  54. ncbi request reprint Persistent pulmonary hypertension of the newborn: therapeutical approach
    Giuseppe Latini
    Division of Neonatology, Perrino Hospital, s s 7 per Mesagne, 72100 Brindisi, Italy
    Mini Rev Med Chem 8:1507-13. 2008
    ..In particular, recent studies seem to show that sildenafil, a phosphodiesterase inhibitor type 5 that selectively reduces pulmonary vascular resistance may be a useful therapeutic adjunct to critically ill neonates with PPHN...
  55. ncbi request reprint In utero exposure to phthalates and fetal development
    Giuseppe Latini
    Division of Neonatology, Ospedale A Perrino, s s 7 per Mesagne, 72100 Brindisi, Italy
    Curr Med Chem 13:2527-34. 2006
    ..Here, we analyze the existing evidence on the link between antenatal phthalate exposure and abnormal fetal development, as well as on possible therapeutic tools to fight the adverse effect of this exposure...
  56. doi request reprint A plasma proteomic approach in Rett syndrome: classical versus preserved speech variant
    Alessio Cortelazzo
    Department of Medical Biotechnologies, University of Siena, Via A Moro 2, 53100 Siena, Italy Child Neuropsychiatry Unit, University Hospital Azienda Ospedaliera Universitaria Senese AOUS, Viale M Bracci 16, 53100 Siena, Italy
    Mediators Inflamm 2013:438653. 2013
    ..Therefore, the examined RTT siblings pairs proved to be an important benchmark model to test the molecular basis of phenotypical expression variability and to identify potential therapeutic targets of the disease. ..
  57. ncbi request reprint Indications and limitations for a neonatal pulse oximetry screening of critical congenital heart disease
    Enrico Rosati
    Division of Neonatology, Perrino Hospital, Brindisi, Italy
    J Perinat Med 33:455-7. 2005
    ..An oximetry screening has been previously proposed. Our aim was to verify the usefulness and consistency of a pulse oximetry screening for early detection of CCVMs in a small size nursery...
  58. ncbi request reprint Low serum concentrations of di-(2-ethylhexyl)phthalate in women with uterine fibromatosis
    Stefano Luisi
    Obstetrics and Gynecology, Department of Pediatrics, Obstetrics, and Reproductive Medicine, University of Siena, Siena, Italy
    Gynecol Endocrinol 22:92-5. 2006
    ..In conclusion, the present findings indicate for the first time that serum DEHP and MEHP concentration are lower in women with uterine fibromatosis, suggesting a possible correlation between phthalate esters and fibromatosis pathology...
  59. ncbi request reprint Congenital oral mucosal abnormalities in true umbilical cord knots
    Claudio De Felice
    Neonatal Intensive Care Unit, Azienda Ospedaliera Universitaria Senese, Siena, Italy
    Biol Neonate 86:34-8. 2004
    ..The pathogenesis and clinical significance of true umbilical cord knots remain controversial. Here, we tested the hypothesis of the presence of congenital oral mucosal changes in newborns with true umbilical cord knots...
  60. ncbi request reprint Phthalate exposure and male infertility
    Giuseppe Latini
    Division of Neonatology, A Perrino Hospital, s s 7 per Mesagne, 72100 Brindisi, Italy
    Toxicology 226:90-8. 2006
    ..Here we review the data that support or discounts the evidence existing to date linking phthalate exposure and the decline of human male fertility, especially in developed countries...
  61. pmc In utero exposure to di-(2-ethylhexyl)phthalate and duration of human pregnancy
    Giuseppe Latini
    Neonatal Intensive Care Unit, Division of Paediatrics, Perrino Hospital, Brindisi, Italy
    Environ Health Perspect 111:1783-5. 2003
    ..50, 95% CI, 1.013-2.21; p = 0.043). These findings confirm that human exposure to DEHP can begin in utero and suggest that phthalate exposure is significantly associated with a shorter pregnancy duration...
  62. ncbi request reprint Inhaled nitric oxide and oral nifedipine in a preterm infant with bronchopulmonary dysplasia and pulmonary hypertension
    Enrico Rosati
    Division of Neonatology, Perrino Hospital, s s 7 per Mesagne, 72100 Brindisi, Italy
    Eur J Pediatr 166:737-8. 2007
  63. ncbi request reprint Placental stress factors and maternal-fetal adaptive response: the corticotropin-releasing factor family
    Pasquale Florio
    Chair of Obstetrics and Gynecology, Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy
    Endocrine 19:91-102. 2002
    ....
  64. doi request reprint Silent increase of urinary ethylmalonic acid is an indicator of nonspecific brain dysfunction
    Raffaella Zannolli
    Azienda Ospedaliera Universitaria Senese, Policlinico Le Scotte, Siena, Italy
    NMR Biomed 23:353-8. 2010
    ..6% sensitivity). These observations are of importance, as we found that subtle increases in urinary EMA levels are frequent in patients with non-specific CNS impairment. The reasons for this association remain unknown...
  65. ncbi request reprint DI-2-ethylhexyl phthalate and endocrine disruption: a review
    Giuseppe Latini
    Division of Pediatrics, Ospedale Perrino, Brindisi, University of Chieti, and 4Neonatal Intensive Care Unit, Azienda Ospedaliera Senese, Siena, Italy
    Curr Drug Targets Immune Endocr Metabol Disord 4:37-40. 2004
    ..In particular, certain members of this chemical class, such as di-[2-ethylhexyl]-phthalate (DEHP), have been shown to cause reproductive and developmental toxicity and are suspected to be endocrine disruptors...
  66. pmc Peroxisome proliferator-activated receptors as mediators of phthalate-induced effects in the male and female reproductive tract: epidemiological and experimental evidence
    Giuseppe Latini
    Division of Neonatology, Perrino Hospital, 72100 Brindisi, Italy
    PPAR Res 2008:359267. 2008
    ..Here, we analyze the epidemiological and experimental evidence linking phthalate exposure to both PPAR activation and adverse effects on male and female reproductive health...
  67. doi request reprint Systemic oxidative stress in classic Rett syndrome
    Claudio De Felice
    Neonatal Intensive Care Unit, University Hospital AOUS of Siena, I 53100 Siena, Italy
    Free Radic Biol Med 47:440-8. 2009
    ..These data identify hypoxia-induced oxidative stress as a key factor in the pathogenesis of classic RS and suggest new therapeutic approaches based on oxidative stress modulation...
  68. doi request reprint EEG features and epilepsy in MECP2-mutated patients with the Zappella variant of Rett syndrome
    Sabrina Buoni
    Department of Pediatrics, Obstetrics and Reproductive Medicine, Section of Child Neurology and Psychiatry Pediatrics, Azienda Ospedaliera Universitaria Senese, S Maria alle Scotte Hospital, Siena, Italy
    Clin Neurophysiol 121:652-7. 2010
    ..To assess the presence/absence of peculiar EEG features and epilepsy in MECP2-mutated Rett patients with the Zappella-Rett variant (Z-RTT) also known as preserved speech variant...
  69. ncbi request reprint Spleen depletion in neonatal sepsis and chorioamnionitis
    Paolo Toti
    Department of Human Pathology and Oncology, Siena University Hospital, University of Siena, Siena, Italy
    Am J Clin Pathol 122:765-71. 2004
    ....
  70. ncbi request reprint Identification of activin A and follistatin in human milk
    Stefano Luisi
    Chair of Obstetrics and Gynecology, Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Policlinico Le Scotte, Viale Bracci, 53100 Siena, Italy
    Growth Factors 20:147-50. 2002
    ..01). Activin A and follistatin are present in human milk in high concentrations in the first week of lactation, while decrease after a month suggesting a possible role as growth factors in human milk...
  71. ncbi request reprint Polyhydramnios: a predictor of severe growth impairment in achondroplasia
    Giuseppe Latini
    Division of Pediatrics, Perrino Hospital, Azienda Ospedaliera A Di Summa, Clinical Physiology Institute IFC CNR, National Research Council of Italy, Lecce Section, Brindisi, Italy
    J Pediatr 141:274-6. 2002
    ..A history of polyhydramnios (9 of 20 cases) was associated with a lower height (SD) (P <.05), more severe shortening of the lower segment and upper limbs (P =.0001), and higher frequency of left-handedness (P =.0081)...
  72. ncbi request reprint Small thymus at birth and gestational age
    Claudio De Felice
    Eur J Pediatr 161:362-3. 2002
  73. ncbi request reprint Small thymus at birth and neonatal outcome in very-low-birth-weight infants
    Claudio De Felice
    Eur J Pediatr 162:204-6. 2003
  74. ncbi request reprint Cerebro-fronto-facial syndrome (Dandy-Walker Variant and frontofacial dysmorphisms): report of the first case identified by increased nuchal translucency beyond 13(+6) weeks
    Gabriele Tonni
    Division of Obstetrics and Gynecology, Guastalla Provincial Hospital, AUSL Reggio Emilia, Italy
    Congenit Anom (Kyoto) 47:68-71. 2007
    ..Careful ultrasonographic follow-up is mandatory in all cases of increased first trimester nuchal translucency with normal karyotype in order to identify associated anomalies...
  75. ncbi request reprint Nephrogenic rests: their frequency and their fate
    Vito Antonio Caiulo
    Division of Pediatrics, Perrino Hospital, Brindisi, and The Italian Study Group on Neonatal Nephrology of the Italian Society of Neonatology, Pediatric Department, School of Medicine, Catholic University of Roma, Italy
    J Pediatr Hematol Oncol 29:361-3. 2007
    ..Our observations indicate that our policy of "wait and see" is appropriate when NRs are identified incidentally during ultrasonographic screening done for whatever purpose...
  76. ncbi request reprint Birth characteristics and hepatoblastoma risk in young children
    Giuseppe Latini
    Cancer 101:210. 2004