G Ronco

..0%. The unadjusted detection rate of CIN2 or more severe histology was 2.9 per 1,000 screened women (3.1 standardised on the Italian population, truncated 25-64)...

..0%. The unadjusted detection rate of CIN2 or more severe histology was 3.2 per 1,000 screened women (3.5 standardised on the Italian population, truncated 25-64)...

..1% of those with known treatment). However, 0.7% of all CIN2 and 1.7% of all CIN3 had hysterectomy. Among the 151 women with invasive carcinoma, 10.6% plausibly with microinvasive disease, only one treatment LLETZ is reported...

..Overall, the intervention increased diagnostic agreement, but its effect varied with laboratory and by diagnostic class and could be transient. Continued programmes of smear exchange and discussion appear to be advisable...

..Nevertheless, there is a clear need to standardise the cytological and histological classifications used in screening, as well as data registration systems across Europe...

..Research on how to best screen vaccinated women is a priority. This paper proposes an overview of the plausible impact of new technologies in cervical cancer screening in the near future and in the vaccinated cohorts...

..HPV-positive women were directly referred to colposcopy if aged 35 or older; if younger, they were retested after 1 year...

..5% (95%CI 58.3-70.3) at age 35-60. In conclusion, triaging by HPV testing performed better in women aged over 35 years than those younger. For older women, HPV triaging should also be considered for managing those with LSIL cytology...

..To compare the accuracy of conventional cytology with liquid based cytology for primary screening of cervical cancer...

..To study the impact of different cervical cancer screening strategies including HPV testing...

..We aimed to compare conventional screening with an experimental strategy in women aged 25-34 years, and investigate the effect of different criteria of referral to define the best methods of HPV screening...

....

..6% of those with known treatment). However 0.4% of all CIN2 and 3.6% of all CIN3 had hysterectomy. Among the 199 women with invasive carcinoma, 12% plausibly with microinvasive disease had only excisional treatment reported...

..For smears indicated to require further review, the system provides maps (PapMaps) to identify the most abnormal areas of the smear...

..In conclusion, overall, the female population of Turin showed an HPV prevalence that is intermediate compared with worldwide levels...

..25 (95% CI 0.13-0.50) for attenders vs non attenders. An organised screening programme can further reduce cervical cancer incidence in an area where substantial spontaneous activity was previously present...

..2%. The unadjusted detection rate of CIN2 or more severe histology was 3.2 per 1,000 screened women (3.2 standardised on the Italian population, truncated 25-64)...

..We assessed the efficacy of cervical-cancer screening policies that are based on HPV testing...

..01%. A need for improvement in the process of evaluation and for homogenization of criteria of cytology interpretation was identified: work in this regard is on-going...

..The unadjusted detection rate ofhistologically confirmed CIN2 or more severe was 2.7 per 1000 screened women (3.0 per 1000, standardised on the Italian population, truncated 25-64)...

..Efficiency can be ensured through the adoption of overbooking, provided that attendance levels are regularly monitored...

..23, 95% CI: 0.00-0.46). Over 50 years of age, after four tests at least three false-positive cases are diagnosed for every true positive. Benefits arising from cytological screening is uncertain in well-screened older women...

..9% of those with known treatment). However 0.7% of all CIN2 and 3.4% of all CIN3 had hysterectomy. Among the 100 women with invasive carcinoma, 17% (plausibly with microinvasive disease) had only excisional treatment reported...

..HPV16 is the prevalent HR-type worldwide associated to cervical cancer. Integration of viral DNA promotes a selective cell growth advantage, resulting a risk factor for cancer development...

..The identification of prognostic factors in the recurrence of vulvar squamous cell carcinoma is crucial for less invasive treatments...

..New Italian guidelines on adequacy proposed the GISCi are presented and the recommendation is made to eliminate the SBLB category...

..Infection with human papillomavirus (HPV) is a necessary step in the progression to cervical cancer. Many methods for HPV testing are currently available, most developed to detect pools of HPV types...

..The unadjusted detection rate of histologically confirmed CIN2 or more severe was 2.7 per 1,000 screened women (2.6 standardised on the Italian population, truncated 25-64)...

..Our study reviews the randomized controlled trials that are currently being conducted in Europe to establish the performance of HPV testing as a primary cervical cancer screening test...

..If HPV testing is applied with cytology-triage, a single HPV test may cost 20-30% more than a conventional Pap to result in the same overall cost per CIN2+ detected...

..91, 0.60, and 0.69 with PreservCyt and 0.93, 0.87, and 0.90 with STM. Our data showed high reliability and reproducibility with HC2, with values higher for STM than ThinPrep (Cytyc) samples...

..Despite this rise, quality indicators were stable. However, in a few programmes, the use of excessively broad criteria in the interpretation of cytology decides an excessively high rate of referrals to colposcopy...

..Some 0.7% of all CIN2 and 5.1% of all CIN3 had hysterectomy. Some 12% of the 111 invasive carcinoma, plausibly microinvasive, had excisional treatment only...

..6% of those with known treatment). However, 1.5 % of all CIN2 and 5.5 % of all CIN3 had hysterectomy. Among the 140 women with invasive carcinoma 17.8%, plausibly with microinvasive disease, had excisional treatment only reported...

..The fact that HPV is a sexually transmitted infection may lead to anxiety and concerns about sexual relationships and these issues are also discussed. Ongoing HPV studies are identified and briefly reviewed...

..These differences, however, underline that great caution should be used in inferring the natural history of HPV from age-specific prevalences...

....

..015). In screening, a low positive predictive value of the colposcopy-referring test may result in unnecessary treatments...

..However, 0.8% of women with CIN2 and 4.2% of women with CIN3 had hysterectomy. Of the 76 women with invasive carcinoma, 19.8%, plausibly with microinvasive disease, had excisional treatment only reported...