Affiliation: CPO Piemonte
Fiano V, Trevisan M, Fasanelli F, Grasso C, Marabese F, da Graça Bicalho M, et al
. Methylation in host and viral genes as marker of aggressiveness in cervical lesions: Analysis in 543 unscreened women. Gynecol Oncol. 2018;151:319-326 pubmed publisher
..001). Our results, empowered by a wide cervical sample series with a large number of hgCIN, supported the role of methylation as marker of aggressiveness. ..
Gillio Tos A, Fiano V, Zugna D, Vizzini L, Pearce N, Delsedime L, et al
. DNA methyltransferase 3b (DNMT3b), tumor tissue DNA methylation, Gleason score, and prostate cancer mortality: investigating causal relationships. Cancer Causes Control. 2012;23:1549-55 pubmed publisher
..93 if adjusted for Gleason score. These findings provide clues on the role of a DNMT3b SNP in prostate cancer progression and illustrate the importance of considering possible causal relationships in the analyses. ..
Gillio Tos A, Bicalho M, Fiano V, Grasso C, Tarallo V, De Marco L, et al
. Case-control study of HLA-G promoter methylation status, HPV infection and cervical neoplasia in Curitiba, Brazil: a pilot analysis. BMC Cancer. 2012;12:618 pubmed publisher
..96, 1.07). This study did not support the hypothesis that spontaneous de-methylation events in the HLA-G promoter play a primary role in promoting escape from immunosurveillance in the development of precancerous cervical lesions. ..
Carozzi F, De Marco L, Gillio Tos A, Del Mistro A, Girlando S, Baboci L, et al
. Age and geographic variability of human papillomavirus high-risk genotype distribution in a large unvaccinated population and of vaccination impact on HPV prevalence. J Clin Virol. 2014;60:257-63 pubmed publisher
..Results suggest that the higher proportion of HPV16/18 related high grade CIN in younger women could be the result of faster progression and not of earlier infection by these types. ..