Alejandro Macchia

Summary

Affiliation: Consorzio Mario Negri Sud
Country: Italy

Publications

  1. pmc N-3 polyunsaturated fatty acids to prevent atrial fibrillation: updated systematic review and meta-analysis of randomized controlled trials
    Javier Mariani
    Fundación GESICA Grupo de Estudio de Investigación Clínica en Argentina, Buenos Aires, Argentina
    J Am Heart Assoc 2:e005033. 2013
  2. doi request reprint Omega-3 fatty acids for the prevention of recurrent symptomatic atrial fibrillation: results of the FORWARD (Randomized Trial to Assess Efficacy of PUFA for the Maintenance of Sinus Rhythm in Persistent Atrial Fibrillation) trial
    Alejandro Macchia
    Fundación GESICA Grupo de Estudio de Investigación Clínica en Argentina, Buenos Aires, Argentina
    J Am Coll Cardiol 61:463-8. 2013
  3. pmc Statins but not aspirin reduce thrombotic risk assessed by thrombin generation in diabetic patients without cardiovascular events: the RATIONAL trial
    Alejandro Macchia
    Department of Medicine, Hospital Aleman, Buenos Aires, Argentina
    PLoS ONE 7:e32894. 2012
  4. ncbi request reprint Previous prescription of β-blockers is associated with reduced mortality among patients hospitalized in intensive care units for sepsis
    Alejandro Macchia
    Laboratory of Pharmacoepidemiology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy
    Crit Care Med 40:2768-72. 2012
  5. doi request reprint Temporal trends of the gaps in post-myocardial infarction secondary prevention strategies of co-morbid and elderly populations vs. younger counterparts: an analysis of three successive cohorts between 2003 and 2008
    Alejandro Macchia
    Laboratory of Pharmacoepidemiology, Consorzio Mario Negri Sud, Via Nazionale 8, Santa Maria Imbaro CH, Italy
    Eur Heart J 33:515-22. 2012
  6. doi request reprint Anemia and chronic heart failure: from pathophysiologic mechanisms to clinical trial designs
    Alejandro Macchia
    Fundación GESICA Clinical Investigation Study Group in Argentina, Avenida Rivadavia 2358, 1 piso oficina 4 C1034ACP Buenos Aires, Argentina
    Expert Rev Cardiovasc Ther 7:139-45. 2009
  7. doi request reprint Unrecognised ventricular dysfunction in COPD
    A Macchia
    Epidemiology Section, Dept of Internal Medicine, CEMIC Centro de Educación Médica e Investigaciones Clínicas, Buenos Aires, Argentina
    Eur Respir J 39:51-8. 2012
  8. ncbi request reprint A meta-analysis of trials of pulmonary hypertension: a clinical condition looking for drugs and research methodology
    Alejandro Macchia
    Consorzio Mario Negri Sud, Santa Maria Imbaro, Chieti, Italy
    Am Heart J 153:1037-47. 2007
  9. ncbi request reprint The prognostic influence of chronic obstructive pulmonary disease in patients hospitalised for chronic heart failure
    Alejandro Macchia
    Department of Clinical Pharmacology and Epidemiology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Chieti, Italy
    Eur J Heart Fail 9:942-8. 2007
  10. ncbi request reprint Clinical trials using vasodilators in pulmonary arterial hypertension: where do we go from here?
    Alejandro Macchia
    Epidemiology Section CEMIC Centro de Educación Médica e Investigaciones Clínicas, Buenos Aires, Argentina
    Rev Recent Clin Trials 6:228-34. 2011

Collaborators

Detail Information

Publications25

  1. pmc N-3 polyunsaturated fatty acids to prevent atrial fibrillation: updated systematic review and meta-analysis of randomized controlled trials
    Javier Mariani
    Fundación GESICA Grupo de Estudio de Investigación Clínica en Argentina, Buenos Aires, Argentina
    J Am Heart Assoc 2:e005033. 2013
    ..We aimed to assess the effects of therapy with n-3 PUFAs on the incidence of recurrent AF and on postoperative AF...
  2. doi request reprint Omega-3 fatty acids for the prevention of recurrent symptomatic atrial fibrillation: results of the FORWARD (Randomized Trial to Assess Efficacy of PUFA for the Maintenance of Sinus Rhythm in Persistent Atrial Fibrillation) trial
    Alejandro Macchia
    Fundación GESICA Grupo de Estudio de Investigación Clínica en Argentina, Buenos Aires, Argentina
    J Am Coll Cardiol 61:463-8. 2013
    ..The aim of this study was to evaluate the efficacy of polyunsaturated fatty acids (n-3 PUFA) for the prevention of recurrent atrial fibrillation (AF) in patients with normal sinus rhythm...
  3. pmc Statins but not aspirin reduce thrombotic risk assessed by thrombin generation in diabetic patients without cardiovascular events: the RATIONAL trial
    Alejandro Macchia
    Department of Medicine, Hospital Aleman, Buenos Aires, Argentina
    PLoS ONE 7:e32894. 2012
    ..We sought to assess the effects of aspirin and statins on the thrombotic risk assessed by thrombin generation (TG) among patients with type II diabetes mellitus and no previous cardiovascular events...
  4. ncbi request reprint Previous prescription of β-blockers is associated with reduced mortality among patients hospitalized in intensive care units for sepsis
    Alejandro Macchia
    Laboratory of Pharmacoepidemiology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy
    Crit Care Med 40:2768-72. 2012
    ..We sought to assess whether patients previously prescribed chronic β-blocker therapy had a different mortality rate than those who did not receive treatment...
  5. doi request reprint Temporal trends of the gaps in post-myocardial infarction secondary prevention strategies of co-morbid and elderly populations vs. younger counterparts: an analysis of three successive cohorts between 2003 and 2008
    Alejandro Macchia
    Laboratory of Pharmacoepidemiology, Consorzio Mario Negri Sud, Via Nazionale 8, Santa Maria Imbaro CH, Italy
    Eur Heart J 33:515-22. 2012
    ..Old and co-morbid populations-although representing a substantial proportion of the burden of disease-received significant less attention and barely improved their survival...
  6. doi request reprint Anemia and chronic heart failure: from pathophysiologic mechanisms to clinical trial designs
    Alejandro Macchia
    Fundación GESICA Clinical Investigation Study Group in Argentina, Avenida Rivadavia 2358, 1 piso oficina 4 C1034ACP Buenos Aires, Argentina
    Expert Rev Cardiovasc Ther 7:139-45. 2009
    ..For these reasons future clinical trials must be designed to be able to elucidate the complexity of mechanisms and the implications for treatment strategies...
  7. doi request reprint Unrecognised ventricular dysfunction in COPD
    A Macchia
    Epidemiology Section, Dept of Internal Medicine, CEMIC Centro de Educación Médica e Investigaciones Clínicas, Buenos Aires, Argentina
    Eur Respir J 39:51-8. 2012
    ..Considering the high prevalence and the prognostic implications of ventricular dysfunction, routine assessment with either BNP or echocardiogram should be considered in COPD patients...
  8. ncbi request reprint A meta-analysis of trials of pulmonary hypertension: a clinical condition looking for drugs and research methodology
    Alejandro Macchia
    Consorzio Mario Negri Sud, Santa Maria Imbaro, Chieti, Italy
    Am Heart J 153:1037-47. 2007
    ..Neither their comparative efficacy on surrogate end points nor the overall impact on mortality have been formally reviewed...
  9. ncbi request reprint The prognostic influence of chronic obstructive pulmonary disease in patients hospitalised for chronic heart failure
    Alejandro Macchia
    Department of Clinical Pharmacology and Epidemiology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Chieti, Italy
    Eur J Heart Fail 9:942-8. 2007
    ..To investigate the prevalence and the prognostic impact of chronic obstructive pulmonary disease (COPD), in patients hospitalised with chronic heart failure (CHF)...
  10. ncbi request reprint Clinical trials using vasodilators in pulmonary arterial hypertension: where do we go from here?
    Alejandro Macchia
    Epidemiology Section CEMIC Centro de Educación Médica e Investigaciones Clínicas, Buenos Aires, Argentina
    Rev Recent Clin Trials 6:228-34. 2011
    ..Despite several clinical trials have been carried out in the last 15 years, their primary objective was not to assess mortality but the changes on surrogate end points...
  11. doi request reprint Omega-3 fatty acid supplementation reduces one-year risk of atrial fibrillation in patients hospitalized with myocardial infarction
    Alejandro Macchia
    Department of Clinical Pharmacology and Epidemiology, Santa Maria Imbaro, Chieti, Italy
    Eur J Clin Pharmacol 64:627-34. 2008
    ..Current strategies for avoiding atrial fibrillation (AF) are of limited value. We aim to assess the relationship between omega-3 fatty acids (n-3 PUFA) and AF occurrence in post-myocardial infarction (MI) patients...
  12. doi request reprint Systematic review of trials using vasodilators in pulmonary arterial hypertension: why a new approach is needed
    Alejandro Macchia
    Department of Clinical Pharmacology and Epidemiology, Consorzio Mario Negri Sud, Via Nazionale 8, Santa Maria Imbaro, Chieti, Italy
    Am Heart J 159:245-57. 2010
    ..Since that last review, 10 new clinical trials with about 1,500 patients have been published, which has increased the statistical power of our observations...
  13. doi request reprint The rationale and design of the FORomegaARD Trial: A randomized, double-blind, placebo-controlled, independent study to test the efficacy of n-3 PUFA for the maintenance of normal sinus rhythm in patients with previous atrial fibrillation
    Alejandro Macchia
    Fundación Grupo de Estudio en Investigación Clínica en Argentina, Buenos Aires, Argentina
    Am Heart J 157:423-7. 2009
    ..Thus, the availability of safer and more effective drugs may reduce the burden of disease...
  14. ncbi request reprint Vitamin E increases the risk of developing heart failure after myocardial infarction: Results from the GISSI-Prevenzione trial
    Roberto Marchioli
    Laboratory of Clinical Epidemiology of Cardiovascular Disease, Department of Clinical Pharmacology and Epidemiology, Consorzio Mario Negri Sud, S Maria Imbaro Ch, Italy
    J Cardiovasc Med (Hagerstown) 7:347-50. 2006
    ..Recently, the HOPE trial showed an increment of the incidence of congestive heart failure (CHF) in patients treated with vitamin E...
  15. ncbi request reprint Antithrombotic treatment is strongly underused despite reducing overall mortality among high-risk elderly patients hospitalized with atrial fibrillation
    Simona Monte
    Department of Clinical Pharmacology and Epidemiology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Chieti 66030, Italy
    Eur Heart J 27:2217-23. 2006
    ..To assess the use of antithrombotic treatment (ATT) after hospitalization with atrial fibrillation (AF) and the attributable effectiveness of ATT during follow-up...
  16. ncbi request reprint A clinically practicable diagnostic score for metabolic syndrome improves its predictivity of diabetes mellitus: the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico (GISSI)-Prevenzione scoring
    Alejandro Macchia
    Consorzio Mario Negri Sud, Santa Maria Imbaro, Chieti, Italy
    Am Heart J 151:754.e7-754.e17. 2006
    ..We aimed to generate a diagnostic score for MS (MS-Score), aimed at predicting diabetes by giving appropriate weight to the individual components of MS...
  17. ncbi request reprint [Determinants of late-onset heart failure in myocardial infarction survivors: GISSI Prevenzione trial results]
    Alejandro Macchia
    Departamento de Farmacología Clínica y Epidemiología, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italia
    Rev Esp Cardiol 58:1266-72. 2005
    ..The factors predicting LHF are not well understood. Our aims were to identify the factors predicting LHF and to determine the survival rate in these patients...
  18. ncbi request reprint Left ventricular systolic dysfunction, total mortality, and sudden death in patients with myocardial infarction treated with n-3 polyunsaturated fatty acids
    Alejandro Macchia
    Consorzio Mario Negri Sud, Santa Maria Imbaro, Chieti, Italy
    Eur J Heart Fail 7:904-9. 2005
    ..In GISSI-Prevenzione, treatment with n-3 polyunsaturated fatty acids (PUFA) reduced M and SD in post-MI patients, but their effect in patients with SyD is unknown...
  19. doi request reprint Depression worsens outcomes in elderly patients with heart failure: an analysis of 48,117 patients in a community setting
    Alejandro Macchia
    Consorzio Mario Negri Sud, Santa Maria Imbaro, Chieti, Italy
    Eur J Heart Fail 10:714-21. 2008
    ..To assess the relationship between depression and clinical outcomes among elderly patients with heart failure (HF) in a community setting...
  20. pmc Exploratory analysis on the use of statins with or without n-3 PUFA and major events in patients discharged for acute myocardial infarction: an observational retrospective study
    Alejandro Macchia
    Laboratory of Pharmacoepidemiology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Chieti, Italy
    PLoS ONE 8:e62772. 2013
    ..We aimed to study the prevalence and the results on major outcomes with CT among patients discharged with a MI in Italy...
  21. ncbi request reprint Metabolic syndrome and risk of cardiovascular events after myocardial infarction
    Giacomo Levantesi
    Consorzio Mario Negri Sud, Santa Maria Imbaro, Chieti, Italy
    J Am Coll Cardiol 46:277-83. 2005
    ..We aimed to assess the prevalence and prognostic role of metabolic syndrome (METS) and diabetes in post-myocardial infarction (MI) patients...
  22. doi request reprint Antidepressants and cardiovascular outcomes in patients without known cardiovascular risk
    Simona Monte
    Department of Clinical Pharmacology and Epidemiology, Laboratory of Pharmacoepidemiology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Chieti, Italy
    Eur J Clin Pharmacol 65:1131-8. 2009
    ..To identify a cohort of subjects without treatment for any cardiovascular risk and analyze the potential causative role of treatment for depression on the development of major cardiovascular outcomes during 2 years of follow-up...
  23. doi request reprint Noninvasive ventilation in acute cardiogenic pulmonary edema: a meta-analysis of randomized controlled trials
    Javier Mariani
    Grupo de Estudio, Docencia e Investigación Clínica, Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
    J Card Fail 17:850-9. 2011
    ..The evidence of individual studies in acute cardiogenic pulmonary edema (ACPE) supporting noninvasive ventilation (NIV) is still inconclusive, particularly regarding noninvasive positive pressure ventilation (NIPPV)...
  24. doi request reprint CARMELA: assessment of cardiovascular risk in seven Latin American cities
    Herman Schargrodsky
    Department of Cardiology, Hospital Italiano de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina
    Am J Med 121:58-65. 2008
    ....
  25. ncbi request reprint Assessment of survival benefit after lung transplantation by patient diagnosis
    Alejandro Macchia
    J Heart Lung Transplant 22:705; author reply 705. 2003