Research Topics
| A RomanoSummaryAffiliation: Complesso Integrato Columbus Country: Italy Publications
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Detail Information
Publications
Delayed hypersensitivity to cefazolin: report on a case involving lymphocyte transformation studies with different cephalosporinsA Romano
Department of Internal Medicine and Geriatrics, UCSC, Columbus, Rome, Italy
Ann Allergy Asthma Immunol 87:238-42. 2001..A cell-mediated immunopathogenic mechanism has been demonstrated in only a few cases of cutaneous reactions to systemically administered cephalosporins...
Anaphylaxis to streptomycinA Romano
, Complesso Integrato Columbus, Via G. Moscati 31, 00168 Rome, Italy
Allergy 57:1087-8. 2002
Diagnosing nonimmediate reactions to penicillins by in vivo testsAntonio Romano
Department of Internal Medicine and Geriatrics, UCSC Allergy Unit, Complesso Integrato Columbus, Rome, Italy
Int Arch Allergy Immunol 129:169-74. 2002....
Food-dependent exercise-induced anaphylaxis: clinical and laboratory findings in 54 subjectsA Romano
Department of Internal Medicine and Geriatrics, UCSC Allergy Unit, Complesso Integrato Columbus, Rome, Italy
Int Arch Allergy Immunol 125:264-72. 2001..Others suffer from anaphylaxis after all meals followed by exercise, regardless of the food eaten (nonspecific FDEIAn). We sought to identify the culprit foods with a diagnostic protocol...
Effective prophylactic protocol in delayed hypersensitivity to contrast media: report of a case involving lymphocyte transformation studies with different compoundsAntonino Romano
Department of Internal Medicine and Geriatrics, Universita Cattolica del Sacro Cuore, Allergy Unit, Complesso Integrato Columbus, via G Moscati 31, 00168 Rome, Italy
Radiology 225:466-70. 2002..The patient received 6-alpha-methylprednisolone and cyclosporine 1 week before and 2 weeks after four angiograms were obtained with the use of iobitridol, which was well tolerated...
Immediate allergic reactions to beta-lactams: diagnosis and therapyA Romano
Department of Internal Medicine and Geriatrics, UCSC Allergy Unit, C I Columbus, Rome, Italy
Int J Immunopathol Pharmacol 16:19-23. 2003..In addition to adrenaline, corticosteroids and antihistamines should be administered. Histamine H(1) receptor antagonists are the mainstay of the treatment of immediate allergic reactions such as urticaria, rhinitis and conjunctivitis...
Recognising antibacterial hypersensitivity in childrenA Romano
Department of Internal Medicine and Geriatrics, UCSC, CI Columbus, Rome, Italy
Paediatr Drugs 2:101-12. 2000..Unfortunately, there are few in vitro tests for evaluating other reactions, and most are not fully validated. In selected cases, provocation tests should be performed...
Delayed hypersensitivity to piperacillinA Romano
Department of Internal Medicine and Geriatrics, UCSC. Allergy Unit C.I. Columbus. Rome, Italy
Allergy 57:459. 2002
Lipid transfer proteins: the most frequent sensitizer in Italian subjects with food-dependent exercise-induced anaphylaxisA Romano
Allergy Unit, Complesso Integrato Columbus, Rome, Italy
Clin Exp Allergy 42:1643-53. 2012..Non-specific FDEIAn (NS-FDEIAn) is a syndrome provoked by exercise performed after ingesting any food...
Delayed hypersensitivity to acylureidopenicillins: a case reportF Gaeta
, Complesso Integrato Columbus, Via G. Moscati, 3100168 Rome, Italy
Allergy 63:787-9. 2008
Allergic reactions to antibiotics, mainly betalactams: facts and controversiesM Viola
Department of Internal Medicine, UCSC, Allergy Unit, Complesso Integrato Columbus, Rome, Italy
Allerg Immunol (Paris) 37:223-9. 2005..In selected cases, provocation tests should be performed...
Benzylpenicillin skin testing is still important in diagnosing immediate hypersensitivity reactions to penicillinsA Romano
Department of Internal Medicine and Geriatrics, UCSC Allergy Unit, Complesso Integrato Columbus, Rome, Italy
Allergy 64:249-53. 2009....
The very limited usefulness of skin testing with penicilloyl-polylysine and the minor determinant mixture in evaluating nonimmediate reactions to penicillinsA Romano
Allergy Unit, Complesso Integrato Columbus, Rome, Italy
Allergy 65:1104-7. 2010....
A comparison of the performance of two penicillin reagent kits in the diagnosis of beta-lactam hypersensitivityA Romano
Department of Internal Medicine and Geriatrics, UCSC Allergy Unit, Complesso Integrato Columbus, Rome, Italy
Allergy 62:53-8. 2007..Therefore, we decided to compare PPL and MDM from Allergopharma (Allergopen) with those from Diater (DAP)...
Selective hypersensitivity to nimesulideM Viola
, Complesso Integrato Columbus, Via G. Moscati 3100168 Rome, Italy
Allergy 63:624-6. 2008
Prevalence of sensitization to Cupressus sempervirens: a 4-year retrospective studyG Papa
Department of Internal Medicine and Geriatrics, UCSC-Allergy Unit, C.I. Columbus, Rome, Italy
Sci Total Environ 270:83-7. 2001..Our study suggests that sensitivity to C. sempervirens is responsible for respiratory symptoms in an increasing percentage of subjects. Further studies are needed to determine its frequency at the national level...
Diagnosing immediate reactions to cephalosporinsA Romano
Department of Internal Medicine and Geriatrics, UCSC Allergy Unit, Complesso Integrato Columbus, via G Moscati 31, 00168 Rome, Italy
Clin Exp Allergy 35:1234-42. 2005..The development of diagnostic tests has been delayed, however, because the cephalosporin allergenic determinants have not been properly identified...
Clinical applications of dynamic susceptibility contrast perfusion-weighted MR imaging in brain tumoursA Romano
NESMOS Department, Neuroradiology Faculty, Sant Andrea Hospital, La Sapienza University, Via di Grottarossa 1035, 00189, Rome, Italy
Radiol Med 117:445-60. 2012..The aim of this review was to analyse the application of perfusion MRI in the study of brain tumours by summarising our personal experience and the main results reported in the literature...
Assessing potential determinants of positive provocation tests in subjects with NSAID hypersensitivityM Viola
Allergy Unit, Complesso Integrato Columbus, Rome, Italy
Clin Exp Allergy 41:96-103. 2011..However, only a few studies have evaluated the potential determinants of positive responses to PTs...
Diagnosis of nonimmediate reactions to beta-lactam antibioticsA Romano
Oasi Maria SS, Troina, and C. I. Columbus, Rome, Italy
Allergy 59:1153-60. 2004....
Heterogeneity of atopic dermatitis defined by the immune response to inhalant and food allergensG Fabrizi
Department of Dermatology, Catholic University of the Sacred Heart, Largo A Gemelli, 8, 00168, Rome, Italy
Eur J Dermatol 9:380-4. 1999..In the present article we hypothesize and argue that the imbalance of the immune system is a consequence of the still unknown etiopathogenetic mechanism of AD, but perhaps not the cause of AD...
Allergy to peanut lipid transfer protein (LTP): frequency and cross-reactivity between peanut and peach LTPA Romano
Department of Internal Medicine and Geriatrics, UCSC Allergy Unit, Complesso Integrato Columbus, Rome, Italy
Eur Ann Allergy Clin Immunol 41:106-11. 2009..Although peanut allergy is frequently reported by LTP-allergic patients, the evidence of the presence of an allergen homologous to LTP in peanuts is limited...
Selective immediate hypersensitivity to cefodizimeA Romano
IRCCS Oasi Maria S.S, Troina, Italy
Allergy 60:1545-6. 2005
Efficacy and tolerability of antibiotics in patients undergoing H. pylori eradicationS Danese
Internal Medicine Department, Gemelli Hospital, Catholic University, Rome, Italy
Hepatogastroenterology 48:465-7. 2001..Quadruple therapy, which appear highly efficacious as a second line therapy, is associated with a significantly higher incidence of side effects when compared to first-line treatment...
Pre-surgical planning and MR-tractography utility in brain tumour resectionA Romano
Department of Neuroradiology, S Andrea Hospital, University Sapienza, Rome, Italy
Eur Radiol 19:2798-808. 2009..In 27 cases, the symptoms had not changed. MR-tractography provides the neurosurgeon with a new anatomical view that has an impact on the surgical resection planning for brain neoplasms...
Headache and visual symptoms in two patients with MRI alterations in posterior cerebral artery territoryM Beccia
Stroke Unit, S Andrea Hospital II Faculty of Medicine, University of Rome Sapienza, Via di Grottarossa 1035, Rome, Italy
Clin Ter 160:125-7. 2009..Normal DWI-MR may help distinguish these patients from those affected by non-reversible ischemic attacks...
Cerebral embolization in patients undergoing protected carotid-artery stenting and carotid surgeryV Faraglia
Department of Vascular Surgery, Sant Andrea Hospital, La Sapienza University of Rome, Second Medical School, Rome, Italy
J Cardiovasc Surg (Torino) 48:683-8. 2007..We evaluated cerebral embolism with diffusion-weighted magnetic resonance imaging (DW-MRI) and transcranial Doppler monitoring during CAS and CEA...
Drug hypersensitivity: insights into pathomechanismsE Martin
Allergy Service, Research Unit for Allergic Diseases, Carlos Haya Hospital, Malaga Spain
Allerg Immunol (Paris) 37:207-12. 2005....
Importance of skin testing with major and minor determinants of benzylpenicillin in the diagnosis of allergy to betalactams. Statement from the European Network for Drug Allergy concerning AllergoPen withdrawalM J Torres
Allergy Service, Carlos Haya Hospital, , Spain
Allergy 61:910-1. 2006
Immediate hypersensitivity reactions to penicillins and other betalactamsC Antunez
Research Unit for Allergic Diseases, Carlos Haya Hospital, Malaga, Spain
Curr Pharm Des 12:3327-33. 2006..These are relevant for the appropriate selection of antimicrobial drugs in patients who have immediate hypersensitivity to betalactams...
Relevance of the determination of serum-specific IgE antibodies in the diagnosis of immediate beta-lactam allergyC Fontaine
Exploration des allergies Maladies Respiratoires and INSERM U454 IFR3, Hopital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier Cedex 5, France
Allergy 62:47-52. 2007..They can be explored by in vivo and/or in vitro tests. The measurement of serum-specific immunoglobulin E (IgE) presents several advantages: safety, simplicity, and availability to nonallergologist physicians...
Differential cytokine and transcription factor expression in patients with allergic reactions to drugsJ A Cornejo Garcia
Research Laboratory for Allergic Diseases, Carlos Haya Hospital Fundacion IMABIS, Malaga, Spain
Allergy 62:1429-38. 2007..We studied the extension of this polarization in DR and IR by examining the cytokine and transcription factor profile in T-cell subpopulations during the acute phase of an ADR...
Non-immediate reactions to beta-lactams: diagnostic value of skin testing and drug provocation testA Padial
Clinica Norsalud, Madrid, Spain
Clin Exp Allergy 38:822-8. 2008..The time between drug intake and the reaction appearance is generally 24-48 h. Because the mechanisms involved are not completely understood, diagnostic tests for these reactions have still to be fully validated...
Monitoring non-immediate allergic reactions to iodine contrast mediaM J Torres
Allergy Service, Carlos Haya Hospital, Malaga, Spain
Clin Exp Immunol 152:233-8. 2008..Moreover, the positive results in skin tests and lymphocyte proliferation tests indicated that an important cross-reactivity exists...
Continued need of appropriate betalactam-derived skin test reagents for the management of allergy to betalactamsM Blanca
Allergy Service, Carlos Haya Hospital, Malaga, Spain
Clin Exp Allergy 37:166-73. 2007..Furthermore, skin tests are the most readily available form of allergy testing for physicians. This paper reviews the results of skin tests in BL allergy and provides evidence for their continued need...
Nonimmediate reactions to systemic corticosteroids suggest an immunological mechanismA Padial
Servicio de Alergologia, Hospital Universitario La Paz, Madrid, Spain
Allergy 60:665-70. 2005..The response to closely related CS was especially marked between betamethasone and dexamethasone, whereas hydrocortisone and deflazacort were well tolerated...
The diagnostic interpretation of basophil activation test in immediate allergic reactions to betalactamsM J Torres
Research Unit for Allergic Diseases, Allergy Service, Carlos Haya Hospital, Malaga, Spain
Clin Exp Allergy 34:1768-75. 2004..Basophil activation by allergens, including drugs, has been used to determine sensitivity and to study IgE recognition and cross-reactivity...
[Hypersensitivity reactions to beta-lactam antibiotics in childhood]M Blanca
Allergol Immunopathol (Madr) 31:103-9. 2003
Immediate hypersensitivity to cephalosporinsAntonino Romano
Department of Internal Medicine and Geriatrics, UCSC-Allergy Unit, Cl Columbus, I-00168 Rome, Italy
Allergy 57:52-7. 2002
Diagnosis of immediate allergic reactions to beta-lactam antibioticsM J Torres
Allergy Service, Carlos Haya Hospital, Malaga, Spain
Allergy 58:961-72. 2003
Disagreement and concerns regarding the article recently published by Macy and Burchette in Allergy 2002;57:1151M Blanca
Allergy 59:111-2; author reply 113. 2004
IgE antibodies to penicillin in skin test negative patientsM J Torres
Servicio de Alergia, Hospital Universitario La Paz, Paseo de La Castellana 2612, 8046 Madrid, Spain
Allergy 57:965. 2002
General considerations for skin test procedures in the diagnosis of drug hypersensitivityK Brockow
, Muenchen, Germany
Allergy 57:45-51. 2002
Controlled administration of penicillin to patients with a positive history but negative skin and specific serum IgE testsM J Torres
Research Unit for Allergic Diseases, Carlos Haya Hospital, Malaga, Spain
Clin Exp Allergy 32:270-6. 2002..This suggests that new diagnostic tests are required so as to limit the use of controlled administration...
Diagnostic evaluation of a large group of patients with immediate allergy to penicillins: the role of skin testingM J Torres
Research Unit for Allergic Diseases, Carlos Haya Hospital, Malaga, Spain
Allergy 56:850-6. 2001..The incorporation of additional reagents and the development of new tests are required, and these will probably change as the patterns of consumption vary...
Clinical evaluation of Pharmacia CAP System RAST FEIA amoxicilloyl and benzylpenicilloyl in patients with penicillin allergyM Blanca
Research Unit for Allergic Diseases, Carlos Haya Hospital, Malaga, Spain
Allergy 56:862-70. 2001..The combination of in vivo and in vitro tests for estimating IgE antibodies to penicillins is important because of the existence of patients with a positive history but negative skin test...
Skin test evaluation in nonimmediate allergic reactions to penicillinsM-J Torres
Research Unit for Allergic Diseases, Carlos Haya Hospital, , Spain
Allergy 59:219-24. 2004..The vehicle (saline or petrolatum) had no influence on the response, although in the former the concentration was critical. The immunohistochemical analysis showed skin infiltrates compatible with a T-cell drug reaction...
T cell assessment in allergic drug reactions during the acute phase according to the time of occurrenceM J Torres
Allergy Service, Carlos Haya Hospital, 29009 Malaga, Spain
Int J Immunopathol Pharmacol 19:119-30. 2006..In delayed reactions there is a parallelism between results found in skin and peripheral blood with a higher participation of CD4+ cells the more severe the reaction...
In vitro T-cell responses to beta-lactam drugs in immediate and nonimmediate allergic reactionsI Luque
Research Unit for Allergic Diseases, Carlos Haya Hospital, , Spain
Allergy 56:611-8. 2001..Interestingly, positive T-cell proliferative responses can be observed 10 or more years after the occurrence of the reaction without further exposure to the drug...
Rapid release of Ole e 1 from olive pollen using different solventsJ Carnes
C B F LETI, S A, Research and Development Department, Tres Cantos, Madrid, Spain
Allergy 57:798-804. 2002..Solubility is an important characteristic of allergenic molecules. The aim of this study was to investigate the solubility of Ole e 1, a major allergen of Olea europaea, using different solvents...
Cytokine and chemokine expression in the skin from patients with maculopapular exanthema to drugsT D Fernandez
Research Laboratory for Allergic Diseases, Carlos Haya Hospital Fundacion IMABIS, Malaga, Spain
Allergy 63:712-9. 2008..We assessed the role of cytokines and chemokines and their receptors in the pathogenesis of MPE...
Side-chain-specific reactions to betalactams: 14 years laterM Blanca
Allergy Service, University Hospital La Paz, Paseo de la Castellana no. 261, 28046 Madrid, Spain
Clin Exp Allergy 32:192-7. 2002
Monoclonal antibodies to amoxicillin express different idiotypes determined by anti-idiotype antibodies productionC Mayorga
Reaearch Unit for Allergic Diseases, Carlos Haya Hospital, , Spain
Allergy 57:45-51. 2002..We conclude that such a small molecule as amoxicillin can present several antigenic determinants that induce a panel of antibody specificities especially directed against the side chain...
Adverse drug reactions with an immunological basis: from clinical practice to basic researchE Sanchez
Allergy Service, University Hospital La Paz, Paseo de la Castellana no 261, E 28046 Madrid, Spain
Allergy 57:41-4. 2002
Pigeon Fancier's Lung after low exposureM Rosal-Sanchez
Hospital Universitario La Paz, Paseo de la Castellana 261, 28046 Madrid, Spain
Allergy 57:649. 2002
Differences in the immunological responses in drug- and virus-induced cutaneous reactions in childrenM J Torres
Research Laboratory for Allergic Diseases, Carlos Haya Hospital, Malaga, Spain
Blood Cells Mol Dis 30:124-31. 2003....
Different lymphocyte markers and cytokine expression in peripheral blood mononuclear cells in children with acute atopic dermatitisC Antunez
Research Unit for Allergic Diseases, Allergy Service, Carlos Haya Hospital, Malaga, Spain
Allergol Immunopathol (Madr) 32:252-8. 2004..AD is characterized by the presence of clinical symptoms of both IgE antibody-mediated immediate hypersensitivity and specific T lymphocyte-mediated delayed hypersensitivity...
Different cytokine production and activation marker profiles in circulating cutaneous-lymphocyte-associated antigen T cells from patients with acute or chronic atopic dermatitisC Antunez
Research Unit for Allergic Diseases, Allergy Service, Carlos Haya Hospital, Malaga, Spain
Clin Exp Allergy 34:559-66. 2004..Atopic dermatitis (AD) is an inflammatory skin disease whose lesions can have two stages: acute and chronic. In skin biopsies a biphasic pattern of cytokine expression has been shown, Th2 in acute lesions and Th1 in chronic AD lesions...
Decrease of selective immunoglobulin E response to amoxicillin despite repeated administration of benzylpenicillin and penicillin VT Fernandez
Research Laboratory for Allergic Diseases, Carlos Haya Hospital, Malaga, Spain
Clin Exp Allergy 35:1645-50. 2005..CONCLUSION: Subjects with selective IgE responses to side-chain-specific determinants seem to become negative, with no influence from subsequent administration of a closely related penicillin...
Memory to the hapten in non-immediate cutaneous allergic reactions to betalactams resides in a lymphocyte subpopulation expressing both CD45RO and CLA markersM Blanca
Research Unit for Allergic Diseases, Carlos Haya Hospital, Malaga, Spain
Blood Cells Mol Dis 31:75-9. 2003..These findings may have relevance to understanding the involvement of T cells in allergic reactions to penicillins...
Anaphylactic reaction following ingestion of fresh heart of palm (Chamaerops humilis L.)M Mayoral
, Hospital Civil, , , Malaga, Spain
Allergy 61:785-6. 2006
Acute generalized exanthematous pustulosis associated with pseudoephedrineM A Padial
Department of Allergy, Hospital Universitario La Paz, P degrees Castellana 261, 28046 Madrid, Spain
Br J Dermatol 150:139-42. 2004..Reverse transcription-polymerase chain reaction revealed an increased expression of IL-8 in AGEP-affected skin...
IgE antibodies to betalactams: relationship between the triggering hapten and the specificity of the immune responseC Antunez
Research Laboratory, Carlos Haya Hospital, Malaga, Spain
Allergy 61:940-6. 2006..After an allergic episode, there is an increase in IgE that decreases over time. We analysed the response of patients allergic to BL after penicillin administration, with emphasis on IgE cross-reactivity...
Skin testing for immediate hypersensitivity to betalactams: comparison between two commercial kitsJ L RodrÃguez-Bada
Research Unit for Allergic Diseases, Allergy Service, Carlos Haya Hospital, Malaga, Spain
Allergy 61:947-51. 2006..The withdrawal of these products from the market has set us back to the early days, before the introduction of reagents for in vivo testing...
Anti-oxidant enzyme activities and expression and oxidative damage in patients with non-immediate reactions to drugsJ A Cornejo-Garcia
Research Laboratory for Allergic Diseases, Carlos Haya Hospital, , Spain
Clin Exp Immunol 145:287-95. 2006..Our observations indicate that oxidative damage occurs in non-immediate reactions. Carbonyl stress and the inadequacy of the anti-oxidant defences are probable causes...
Drug provocation testing in the diagnosis of drug hypersensitivity reactions: general considerationsW Aberer
Department of Environmental Dermatology, University of Graz, Auenbruggerplatz 8, A-8036 Graz, Austria
Allergy 58:854-63. 2003
Penicillin allergyM J Torres
Clin Exp Allergy 33:714. 2003
Diagnostic tests based on human basophils: more potentials and perspectives than pitfalls. II. Technical issuesA L De Week
University of Navarra, Pamplona, Spain
J Investig Allergol Clin Immunol 18:143-55. 2008....
