Research Topics
| Manuela ColafigliSummaryCountry: Italy Publications
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Detail Information
Publications
Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010M Colafigli
Institute of Clinical Infectious Diseases, Catholic University of S Heart, Rome, Italy
Clin Microbiol Infect 18:E299-304. 2012..TDR significantly declined overall and for the single drug classes. Older age independently predicted increased odds of TDR, whereas a more recent GRT, a higher HIV-RNA and C vs. B subtype predicted lower odds of TDR...
Long-term follow-up of nevirapine-treated patients in a single-centre cohortManuela Colafigli
Institute of Clinical Infectious Diseases, Catholic University of the Sacred Heart, Rome, Italy
HIV Med 10:461-9. 2009..We reviewed the safety and efficacy of nevirapine (NVP)-based therapy in all patients initiating NVP-containing combined antiretroviral therapy [cART (>or=3 drugs)] in our clinic since 1994...
Cardiovascular risk score change in HIV-1-infected patients switched to an atazanavir-based combination antiretroviral regimenM Colafigli
Institute of Clinical Infectious Diseases, Catholic University of Sacred Heart, Rome, Italy
HIV Med 9:172-9. 2008....
Virological suppression reduces clinical progression in patients with multiclass-resistant HIV type 1Laura Bracciale
Institute of Clinical of Infectious Disease, Catholic University of Sacred Heart, Rome, Italy
AIDS Res Hum Retroviruses 25:261-7. 2009..The achievement of virological suppression is a strong predictor of reduced clinical progression...
Declining prevalence of HIV-1 drug resistance in treatment-failing patients: a clinical cohort studySimona Di Giambenedetto
Institute of Clinical Infectious Diseases, Catholic University, Rome, Italy
Antivir Ther 12:835-9. 2007..We explored the evolution of genotypic drug resistance prevalence in treatment-failing patients from 1999 to 2005 in a clinical cohort...
Improved interpretation of genotypic changes in the HIV-1 reverse transcriptase coding region that determine the virological response to didanosineAndrea De Luca
Institute of Clinical Infectious Diseases, Catholic University, Roma, 00168, Italy
J Infect Dis 196:1645-53. 2007..Consensus on the interpretation of mutations in the human immunodeficiency virus (HIV)-1 reverse transcriptase (RT) gene that predict the response to didanosine treatment is needed...
Genotypic resistance to lopinavir and fosamprenavir with or without ritonavir of clinical isolates from patients failing protease inhibitors-containing HAART regimens: prevalence and predictorsSimona Di Giambenedetto
Institute of Clinical Infectious DiseasesCatholic University, Rome, Italy
Scand J Infect Dis 39:813-8. 2007..In patients failing PIs, the interpretation of genotypic resistance to fosamprenavir may change considerably according to the different algorithms and in respect to the effect of pharmacokinetic boosting with ritonavir...
Comparative determination of HIV-1 co-receptor tropism by Enhanced Sensitivity Trofile, gp120 V3-loop RNA and DNA genotypingMattia C F Prosperi
Infectious Diseases Clinic, Catholic University of Sacred Heart, Rome, Italy
Retrovirology 7:56. 2010..7% false positive rate cutoff were evaluated using viral DNA and RNA samples, compared against each other and ESTA, using Cohen's kappa, phylogenetic analysis, and area under the receiver operating characteristic (AUROC)...
Predictors of first-line antiretroviral therapy discontinuation due to drug-related adverse events in HIV-infected patients: a retrospective cohort studyMattia C F Prosperi
Viral Immunodeficiency Unit, National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
BMC Infect Dis 12:296. 2012..However, its determinants are not fully understood. Aim of this study was to investigate predictors of first-line antiretroviral therapy discontinuation due to adverse events and their evolution in recent years...
The effect of polymorphisms in candidate genes on the long-term risk of lipodystrophy and dyslipidemia in HIV-infected white patients starting antiretroviral therapyAngela Marzocchetti
Institute of Clinical Infectious Diseases, Catholic University of Sacred Heart, Rome, Italy
AIDS Res Hum Retroviruses 27:1299-309. 2011..10; p=0.04). Knowledge of the effect of genetic determinants on dyslipidemia and lipodystrophy may prompt the investigation of potential pathogenetic mechanisms and might eventually be used for guiding individualized treatment decisions...
Revised central nervous system neuropenetration-effectiveness score is associated with cognitive disorders in HIV-infected patients with controlled plasma viraemiaNicoletta Ciccarelli
Institute of Clinical Infectious Diseases, Catholic University of the Sacred Heart, Rome, Italy
Antivir Ther 18:153-60. 2013..The objective of our study was to compare two different central nervous system penetration-effectiveness (CPE) scores for the prediction of cognitive dysfunction in HIV-infected patients...
Interpretation systems for genotypic drug resistance of HIV-1Andrea De Luca
Istituto di Clinica delle Malattie Infettive, , Rome, Italy
Scand J Infect Dis Suppl 35:29-34. 2003..Importantly, only 8 systems were intended for clinical use and 5 of these had at least partially undergone clinical validation...
