G Ciprandi

Summary

Country: Italy

Publications

  1. doi request reprint Bronchodilation test in patients with allergic rhinitis
    G Ciprandi
    Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, Italy
    Allergy 66:694-8. 2011
  2. ncbi request reprint Comparison of serum specific IgE and skin prick test in polysensitized children
    Giorgio Ciprandi
    Department of Ilnternal Medicine, Azienda Ospedaliera Universitaria San Martino University of Geno, Genoa, Italy
    Clin Lab 57:83-5. 2011
  3. doi request reprint Serum neopterin levels in spontaneous urticaria and atopic dermatitis
    G Ciprandi
    Department of Internal Medicine, University Hospital San Martino, University of Genoa, Genoa, Italy
    Clin Exp Dermatol 36:85-7. 2011
  4. doi request reprint Serum leptin levels depend on allergen exposure in patients with seasonal allergic rhinitis
    Giorgio Ciprandi
    Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, University of Genoa, Genoa, Italy
    Immunol Invest 38:681-9. 2009
  5. doi request reprint Clinical assessment of a nasal decongestion test by visual analog scale in allergic rhinitis
    Giorgio Ciprandi
    Azienda Ospedaliera Universitaria San Martino, Genoa, Italy
    Am J Rhinol 22:502-5. 2008
  6. pmc Clinical utility and patient adherence with ebastine for allergic rhinitis
    Giorgio Ciprandi
    Department of Internal Medicine, San Martino Hospital, Genoa, Italy
    Patient Prefer Adherence 4:389-95. 2010
  7. pmc Recent developments in United airways disease
    Giorgio Ciprandi
    IRCCS University Hospital San Martino, Genoa, Italy
    Allergy Asthma Immunol Res 4:171-7. 2012
  8. pmc The Age Impact on Serum Total and Allergen-Specific IgE
    Mara De Amici
    Allergy Lab, IRCCS San Matteo Fundation, Pavia, Italy
    Allergy Asthma Immunol Res 5:170-4. 2013
  9. ncbi request reprint Methacholine bronchial challenge effects on nasal symptoms and function in patients with allergic rhinitis
    I Cirillo
    Eur Ann Allergy Clin Immunol 45:123-9. 2013
  10. doi request reprint CD64 expression on monocytes in children with adenoid hypertrophy
    Fabio Pagella
    Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
    Asian Pac J Allergy Immunol 31:132-7. 2013

Detail Information

Publications138 found, 100 shown here

  1. doi request reprint Bronchodilation test in patients with allergic rhinitis
    G Ciprandi
    Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, Italy
    Allergy 66:694-8. 2011
    ..The aim of this study was to evaluate a large group of adult AR patients to investigate the frequency of response to bronchodilation test and FEF₂₅₋₇₅ values...
  2. ncbi request reprint Comparison of serum specific IgE and skin prick test in polysensitized children
    Giorgio Ciprandi
    Department of Ilnternal Medicine, Azienda Ospedaliera Universitaria San Martino University of Geno, Genoa, Italy
    Clin Lab 57:83-5. 2011
    ..The aim of this study was to evaluate serum specific-IgE in a large group of polysensitized patients with the same SPT result (such as ++++) comparing the two diagnostic methods...
  3. doi request reprint Serum neopterin levels in spontaneous urticaria and atopic dermatitis
    G Ciprandi
    Department of Internal Medicine, University Hospital San Martino, University of Genoa, Genoa, Italy
    Clin Exp Dermatol 36:85-7. 2011
    ..This preliminary study demonstrates that serum neopterin could be a biomarker of immune activation in patients with SU or AD...
  4. doi request reprint Serum leptin levels depend on allergen exposure in patients with seasonal allergic rhinitis
    Giorgio Ciprandi
    Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, University of Genoa, Genoa, Italy
    Immunol Invest 38:681-9. 2009
    ..0004 and 0.0031 respectively), symptomatic female patients showed significantly higher levels than normal females (p = 0.0002). This study provides the evidence that leptin serum levels depend on allergen exposure in SAR patients...
  5. doi request reprint Clinical assessment of a nasal decongestion test by visual analog scale in allergic rhinitis
    Giorgio Ciprandi
    Azienda Ospedaliera Universitaria San Martino, Genoa, Italy
    Am J Rhinol 22:502-5. 2008
    ..The aim of this study was to verify the suitability of the use of the visual analog scales (VASs) as a surrogate for rhinomanometry in the decongestion test assessment in patients with persistent allergic rhinitis...
  6. pmc Clinical utility and patient adherence with ebastine for allergic rhinitis
    Giorgio Ciprandi
    Department of Internal Medicine, San Martino Hospital, Genoa, Italy
    Patient Prefer Adherence 4:389-95. 2010
    ..In conclusion, ebastine is an effective and well tolerated antihistamine that may be prescribed for the treatment of AR. The fast-dissolving tablet formulation provides a new option which may be particularly convenient for the patient...
  7. pmc Recent developments in United airways disease
    Giorgio Ciprandi
    IRCCS University Hospital San Martino, Genoa, Italy
    Allergy Asthma Immunol Res 4:171-7. 2012
    ..Physicians should always keep these notions in mind, and evaluate and treat respiratory diseases taking into account the unity of the respiratory tract...
  8. pmc The Age Impact on Serum Total and Allergen-Specific IgE
    Mara De Amici
    Allergy Lab, IRCCS San Matteo Fundation, Pavia, Italy
    Allergy Asthma Immunol Res 5:170-4. 2013
    ..0001), with a specific trend pattern for each allergen. Total IgE increased with age, but allergen-specific IgE levels significantly decreased with age, with a trend specific for each allergen tested...
  9. ncbi request reprint Methacholine bronchial challenge effects on nasal symptoms and function in patients with allergic rhinitis
    I Cirillo
    Eur Ann Allergy Clin Immunol 45:123-9. 2013
    ..However, severity of nasal obstruction perception might predict BHR. ..
  10. doi request reprint CD64 expression on monocytes in children with adenoid hypertrophy
    Fabio Pagella
    Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
    Asian Pac J Allergy Immunol 31:132-7. 2013
    ..Adenoids with obstructive hypertrophy (AH) are considered to be one of the most ancient and common problems in Paediatrics. This study aimed at investigating the expression of CD 64 on monocytes in children who had to undergo adenoidectomy...
  11. ncbi request reprint Tetanus toxoid IgE may be useful in predicting allergy during childhood
    G Ciprandi
    Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, Genoa, Italy
    J Biol Regul Homeost Agents 26:S119-23. 2012
    ..Total IgE summed with tetanus specific IgE were significantly associated with allergy at 12 years. In conclusion, this study demonstrates that serum total IgE and tetanus specific IgE may be predictive of subsequent allergy onset...
  12. ncbi request reprint Patients with oral allergic syndrome to apple have intense proliferative response to BET V 1
    G Ciprandi
    Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, Genoa, Italy
    J Biol Regul Homeost Agents 26:S113-7. 2012
    ..Thus, this study confirms the previous report and underlines the relevance of measuring recombinant birch allergen as higher values may suggest a reliable prediction of OAS...
  13. ncbi request reprint Impaired spirometry may suggest sensitization
    G Ciprandi
    Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, Genoa, Italy
    J Biol Regul Homeost Agents 26:S15-7. 2012
    ..Therefore, when spirometry is abnormal, mainly concerning FEF25-75, sensitization should be suspected...
  14. doi request reprint Serum IL-23 strongly and inversely correlates with FEV1 in asthmatic children
    Giorgio Ciprandi
    Azienda Ospedaliera Universitaria San Martino, IRCCS, Genoa, Italy
    Int Arch Allergy Immunol 159:183-6. 2012
    ..IL-23 is a cytokine that may be implicated in modulating Th17 response. This study aimed at evaluating IL-23 and relating it to lung function in asthmatic children...
  15. ncbi request reprint Relationships between allergic inflammation and nasal airflow in children with seasonal allergic rhinitis
    Giorgio Ciprandi
    Ospedale San Martino, Genoa, Italy
    Ann Allergy Asthma Immunol 94:258-61. 2005
    ..Allergic rhinitis is characterized by a T(H)2-dependent inflammation. Nasal obstruction is a typical symptom of allergic rhinitis...
  16. ncbi request reprint Allergen-specific Ig classes in non-allergic individuals
    G Ciprandi
    Department of Internal Medicine, University of Genoa, Genoa, Italy
    J Biol Regul Homeost Agents 24:335-40. 2010
    ..In addition, this study is the first that quantitatively evaluates the Ig classes...
  17. doi request reprint Serum adiponectin levels in patients with pollen-induced allergic rhinitis
    Giorgio Ciprandi
    Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino University of Genoa Genoa, Italy
    Int Immunopharmacol 8:945-9. 2008
    ..Several studies have outlined a possible relationship between an increased body mass index and respiratory allergic diseases, such as asthma and rhinitis...
  18. ncbi request reprint Emerging anti-inflammatory agents for allergic rhinitis
    Giorgio Ciprandi
    Dipartimento Patologie Testa Collo, Azienda Ospedaliera Universitaria San Martino, Allergologia U O ORL, Largo R Benzi 10, 16132 Genoa, Italy
    Expert Opin Emerg Drugs 10:689-705. 2005
    ..Finally, one of the major goals is to modify the TH2-biased immune response by improving the characteristics and modes of action of allergen immunotherapy...
  19. ncbi request reprint Serum IL-4 as a marker of immunological response to sublingual immunotherapy
    G Ciprandi
    Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, Genoa University, Genoa, Italy
    J Biol Regul Homeost Agents 22:117-23. 2008
    ..In conclusion, these results may be considered clinically relevant proof that SLIT treatment induces a quick reduction in Th2 polarization. Serum IL-4 appears to be an early marker of immunological response to SLIT...
  20. ncbi request reprint Sublingual immunotherapy in polysensitized allergic patients with rhinitis and/or asthma: allergist choices and treatment efficacy
    G Ciprandi
    Department of Internal Medicine, University Hospital San Martino, Genoa
    J Biol Regul Homeost Agents 23:165-71. 2009
    ..In conclusion, these findings provide preliminary evidence that SIT is effective and safe in polysensitized patients after 1 year of treatment also using single extracts, and thus does not represent an obstacle for prescribing SIT...
  21. doi request reprint Visual analog scale (VAS) and nasal obstruction in persistent allergic rhinitis
    Giorgio Ciprandi
    Department of Internal Medicine, Genoa University, Genoa, Italy
    Otolaryngol Head Neck Surg 141:527-9. 2009
    ..The aim of this study was to verify the suitability of the use of visual analog scales (VAS) as a surrogate for rhinomanometry in quantifying nasal obstruction in patients with persistent allergic rhinitis...
  22. doi request reprint Serum adipsin levels in patients with seasonal allergic rhinitis: preliminary data
    Giorgio Ciprandi
    Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino University of Genoa, Genoa, Italy
    Int Immunopharmacol 9:1460-3. 2009
    ..Several studies have outlined a possible relationship between adipokines and respiratory allergic diseases. However, there are no data about a role for adipsin in allergic rhinitis...
  23. ncbi request reprint Persistent allergic rhinitis includes different pathophysiologic types
    Giorgio Ciprandi
    Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, Genoa, Italy
    Laryngoscope 118:385-8. 2008
    ..However, it has been previously reported that each single allergen may induce different clinical and pathophysiologic features...
  24. doi request reprint Relationship between rhinitis duration and response to nasal decongestion test
    Giorgio Ciprandi
    Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, Genoa, Italy
    Laryngoscope 118:1139-41. 2008
    ..The purpose of the study was to evaluate the impact of the duration of rhinitis on the response to nasal decongestion test in a cohort of patients with PER...
  25. doi request reprint Forced expiratory flow between 25 and 75% of vital capacity might be a predictive factor for bronchial hyperreactivity in children with allergic rhinitis, asthma, or both
    Giorgio Ciprandi
    Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, Genoa, Italy
    Allergy Asthma Proc 32:e22-8. 2011
    ..9). In conclusion, this pediatric study confirmed that impaired FEF(25-75) values might predict severe BHR in children, mainly in those with allergic rhinitis. Therefore, low FEF(25-75) values could suggest BHR in children...
  26. ncbi request reprint Nasal obstruction is the key symptom in hay fever patients
    Giorgio Ciprandi
    Cirillo and Vizzaccaro Ospedale Marina Militare, Genoa, Italy
    Otolaryngol Head Neck Surg 133:429-35. 2005
    ..Allergic rhinitis is characterized by a Th2-dependent inflammation. Nasal obstruction largely depends on allergic inflammation...
  27. doi request reprint Visual analogue scale assessment of nasal obstruction might define patients candidates to spirometry
    G Ciprandi
    Department of Internal Medicine, San Martino Hospital, Genoa, Italy
    Rhinology 49:292-6. 2011
    ..Bronchial obstruction is a characteristic of asthma and spirometry is a cardinal step in asthma diagnosis. However, spirometry is rarely suitable in medical office. Visual Analogue Scales (VAS) is frequently used in common practice...
  28. ncbi request reprint Airway function and nasal inflammation in seasonal allergic rhinitis and asthma
    G Ciprandi
    Ospedale San Martino, Genoa, Italy
    Clin Exp Allergy 34:891-6. 2004
    ..Allergic rhinitis (AR) and asthma are frequently associated and characterized by a Th2-dependent inflammation. Nasal and bronchial obstruction may be objectively measured...
  29. ncbi request reprint Onset of oral allergic syndrome during birch sublingual immunotherapy
    G Ciprandi
    Allergy and Respiratory Diseases Clinic IRCCS Azienda Ospedaliera Universitaria San Martino, Genoa, Italy
    Eur Ann Allergy Clin Immunol 44:170-1. 2012
    ..Some studies reported a possible positive effect exerted by allergen-specific immunotherapy on OAS course, while others did not. A case of OAS case onset after starting sublingual immunotherapy is reported...
  30. pmc Allergen specificity is relevant for immunotherapy prescription in polysensitised children
    Giorgio Ciprandi
    IRCCS Azienda Ospedaliera Universitaria San Martino di Genova, Viale Benedetto XV 6, 16132, Genoa, Italy
    Ital J Pediatr 38:50. 2012
    ..There are allergens that are frequent, but not prescribed. This issue should be matter of adequate debate for Italian paediatricians...
  31. doi request reprint Monosensitization and polysensitization in allergic rhinitis
    Giorgio Ciprandi
    Department of Internal Medicine, University of Genoa, Genoa, Italy
    Eur J Intern Med 22:e75-9. 2011
    ..Polysensitization is common in patients with allergic rhinitis (AR) and may affect clinical feature. However, there are patients who remain monosensitized...
  32. doi request reprint Nitric oxide metabolites in allergic rhinitis: The effect of pollen allergen exposure
    G Ciprandi
    Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino University of Genoa, Genoa, Italy
    Allergol Immunopathol (Madr) 39:326-9. 2011
    ..Seasonal allergic rhinitis (SAR) is characterised by an inflammation consequent to allergen exposure. Nitric oxide may be involved in allergic inflammation...
  33. doi request reprint Sublingual immunotherapy reduces soluble HLA-G and HLA-A,-B,-C serum levels in patients with allergic rhinitis
    Giorgio Ciprandi
    DIMI, University of Genoa, Genoa, Italy
    Int Immunopharmacol 9:253-7. 2009
    ..Therefore, the clinical implication of this study is that these soluble molecules might be interpreted as biomarker of response to SLIT...
  34. doi request reprint Tryptophan metabolism in allergic rhinitis: the effect of pollen allergen exposure
    Giorgio Ciprandi
    Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, University of Genoa, Genoa, Italy
    Hum Immunol 71:911-5. 2010
    ..In conclusion, this preliminary study demonstrates that serum tryptophan metabolism could serve as a biomarker in patients with AR...
  35. ncbi request reprint Immunoglobulin production pattern is allergen-specific in polysensitized patients
    G Ciprandi
    Department of Internal Medicine, University of Genoa, Genoa, Italy
    Int J Immunopathol Pharmacol 22:809-17. 2009
    ..In conclusion, the present study provides the first evidence that immunoglobulin production pattern depends on the specificity of the allergenic response...
  36. ncbi request reprint Body mass index is related with bronchial function and reversibility in children with allergic rhinitis and asthma
    G Ciprandi
    Department of Internal Medicine, IRCCS Azienda Ospedaliera Universitaria San Martino, Genoa, Italy
    Int J Immunopathol Pharmacol 24:21-4. 2011
    ..As reversibility is related with bronchial inflammation, this finding might underline a link between overweight and allergic inflammation...
  37. doi request reprint Impact of allergic rhinitis on asthma: effects on bronchodilation testing
    Giorgio Ciprandi
    Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, Genoa, Italy
    Ann Allergy Asthma Immunol 101:42-6. 2008
    ..A remarkable relationship exists between the upper and lower airways. Bronchial obstruction is a paramount feature of asthma, and its reversibility is considered a main step in asthma diagnosis...
  38. doi request reprint TGF-beta and IL-17 serum levels and specific immunotherapy
    Giorgio Ciprandi
    Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, University of Genoa, Genoa, Italy
    Int Immunopharmacol 9:1247-9. 2009
    ..Therefore, this study provides clinically relevant evidence that two pre-seasonal SLIT courses may significantly affect serum TGF-beta levels...
  39. doi request reprint Carry-over effect on IFN-gamma production induced by allergen-specific immunotherapy
    Giorgio Ciprandi
    Department of Internal Medicine CEBR, University of Genoa, Genoa, Italy
    Int Immunopharmacol 8:1622-5. 2008
    ..Allergic rhinitis is characterized by Th2 polarization and defective IFN-gamma production. Specific immunotherapy determines an allergen-specific clinical improvement...
  40. ncbi request reprint Soluble HLA-G molecule in patients with perennial allergic rhinitis
    Giorgio Ciprandi
    Department of Internal Medicine, University of Genoa, Genoa, Italy
    Int Arch Allergy Immunol 150:278-81. 2009
    ..Allergic rhinitis (AR) is characterized by T helper 2 polarized immune response. The soluble HLA-G (sHLA-G) molecule has an immunomodulatory activity. However, so far, no study has investigated this activity in perennial AR (PAR)...
  41. doi request reprint Spirometric abnormalities in patients with allergic rhinitis: Indicator of an "asthma march"?
    Giorgio Ciprandi
    Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, Genoa, Italy
    Am J Rhinol Allergy 25:e181-5. 2011
    ..The aim of this study was to assess forced expiratory flow at 25-75% (FEF(25-75)), forced expiratory volume at 1 second (FEV(1)), and response to bronchodilation test in a large group of AR patients...
  42. ncbi request reprint Soluble serum HLA-G and HLA-A, -B, -C molecules in patients with seasonal allergic rhinitis exposed to pollens
    Giorgio Ciprandi
    Department of Internal Medicine, University of Genoa, Italy
    Int Immunopharmacol 9:1058-62. 2009
    ..To date, however, no study has investigated there in AR patients during the pollen season...
  43. doi request reprint Body mass index, respiratory function and bronchial hyperreactivity in allergic rhinitis and asthma
    Giorgio Ciprandi
    Department of Internal Medicine, University of Genoa, Genoa, Italy
    Respir Med 103:289-95. 2009
    ....
  44. ncbi request reprint Sublingual immunotherapy provides an early increase of interferon-gamma production
    G Ciprandi
    Azienda Ospedaliera Universitaria San Martino and DIMI CEBR, University of Genoa, Genoa, Italy
    J Biol Regul Homeost Agents 22:169-73. 2008
    ..001) and medication use (p<0.01). In conclusion, these results may be considered clinically relevant as SLIT treatment may induce a quick IFN- gamma response that is related to clinical improvement...
  45. ncbi request reprint Relationship between severity of rhinitis symptoms and nasal airflow
    Giorgio Ciprandi
    Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, Genoa, Italy
    Rhinology 46:209-12. 2008
    ..Allergic rhinitis (AR) is characterized by inflammatory events that lead to the onset of typical nasal symptoms, including itching, sneezing, rhinorrhea and obstruction...
  46. ncbi request reprint Sublingual immunotherapy in polysensitized patients: effect on quality of life
    G Ciprandi
    Department of Internal Medicine, University of Genoa, Genoa, Italy
    J Investig Allergol Clin Immunol 20:274-9. 2010
    ..However, there are no data concerning QOL after sublingual immunotherapy (SLIT) in polysensitized patients...
  47. doi request reprint Peripheral Th-17 cells in allergic rhinitis: New evidence
    Giorgio Ciprandi
    Department of Internal Medicine C E B R, University of Genoa, Azienda Ospedaliera Universitaria San Martino, Genoa, Italy
    Int Immunopharmacol 10:226-9. 2010
    ..Th17 is a subset of T helper lymphocytes exerting inflammatory activities. Recently, it has been reported that serum IL-17 levels are high in patients with severe birch allergy...
  48. doi request reprint Serum transforming growth factor-beta levels depend on allergen exposure in allergic rhinitis
    Giorgio Ciprandi
    Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, University of Genoa, Genoa, Italy
    Int Arch Allergy Immunol 152:66-70. 2010
    ..Patients were evaluated either outside the pollen season and after 1 preseasonal sublingual immunotherapy (SLIT) course (38 subjects) or during the pollen season (57 subjects)...
  49. ncbi request reprint Sublingual immunotherapy mechanisms of action: the role of Th1 response
    G Ciprandi
    Semeiotica e Metodologia Medica I, Dipartimento di Medicina Interna, University Hospital San Martino, Genoa, Italy
    Int J Immunopathol Pharmacol 22:9-12. 2009
    ..Therefore, also SLIT is able of exerting the effects on immune response as well as the subcutaneous route...
  50. doi request reprint Serum IL-9 levels depend on allergen exposure: preliminary study
    Giorgio Ciprandi
    Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, University of Genoa, Genoa, Italy
    Int Arch Allergy Immunol 154:246-8. 2011
    ..Serum IL-9 levels are related to symptom severity in patients with allergic rhinitis (AR). This study aimed at investigating whether IL-9 may depend on allergen exposure...
  51. doi request reprint Sublingual immunotherapy may affect serum neopterin: preliminary findings
    Giorgio Ciprandi
    Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, University of Genoa, Genoa, Italy
    Int Immunopharmacol 10:1474-6. 2010
    ..However, there are few studies in allergic rhinitis (AR). This study evaluated the serum neopterin levels in patients with pollen-induced AR or treated with sublingual immunotherapy (SLIT) and in healthy subjects...
  52. ncbi request reprint Assessment of the bronchodilation test by visual analog scale in the selection of patients with rhinitis for screening spirometry
    G Ciprandi
    Dipartimento di Medicina Interna, Università di Genova Azienda Ospedaliera Universitaria San Martino di Genova, Genova, Italy
    J Investig Allergol Clin Immunol 20:419-24. 2010
    ..However, reversibility testing requires a spirometer, which is rarely available in the doctor's office. Visual analog scales (VAS) are frequently used in daily practice...
  53. doi request reprint Exhaled nitric oxide in children with allergic rhinitis and/or asthma: a relationship with bronchial hyperreactivity
    Giorgio Ciprandi
    Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino University of Genoa, Genoa, Italy
    J Asthma 47:1142-7. 2010
    ..The aim of this study was to evaluate whether FeNO measurement is predictable for bronchial hyperreactivity (BHR) in children with allergic rhinitis, asthma, or both...
  54. doi request reprint Comparison between symptoms and endoscopy in children with nasal obstruction
    Giorgio Ciprandi
    Department of Internal Medicine, Genoa University, Italy
    Int J Pediatr Otorhinolaryngol 74:1405-8. 2010
    ..The aim of the study was to compare the use of both a Face Related Scale (FRS), recorded by children and their parents, and a simplified Visual Analogue Scales (sVAS) with nasal endoscopy in children complaining nasal obstruction...
  55. ncbi request reprint Nasal obstruction in patients with seasonal allergic rhinitis: relationships between allergic inflammation and nasal airflow
    Giorgio Ciprandi
    Ospedale San Martino, Genoa, Italy
    Int Arch Allergy Immunol 134:34-40. 2004
    ..The aim of this study was to evaluate the possible relationships between allergic inflammation, including inflammatory cells and cytokine pattern, and nasal airflow in patients with nasal obstruction due to seasonal allergic rhinitis...
  56. doi request reprint Impact of allergic rhinitis on bronchi: an 8-year follow-up study
    Giorgio Ciprandi
    Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino University of Genoa, Italy
    Am J Rhinol Allergy 25:e72-6. 2011
    ..The aim of this study was to follow up a group of patients with allergic rhinitis to investigate the onset of possible spirometric abnormalities and/or bronchial hyperreactivity (BHR)...
  57. ncbi request reprint Adipokines and their role in allergies
    G Ciprandi
    Department of Internal Medicine, IRCCS Azienda Ospedaliera Universitaria San Martino, Genoa, Italy
    Int J Immunopathol Pharmacol 24:13-6. 2011
    ..Several studies have been published on the role of different adipokines on allergic diseases. We focus our review on the role of adipokines on asthma and allergic rhinitis...
  58. ncbi request reprint FEF(25-75) might be a predictive factor for bronchial inflammation and bronchial hyperreactivity in adolescents with allergic rhinitis
    G Ciprandi
    Department of Internal Medicine, IRCCS Azienda Ospedaliera Universitaria San Martino, Genoa, Italy
    Int J Immunopathol Pharmacol 24:17-20. 2011
    ..Conclusion This study provides evidence that impaired FEF25-75 values might predict severe BHR and BHR is related with FeNO in adolescents. Therefore, BHR should be suspected in adolescents with low FEF25-75 values...
  59. doi request reprint Association of childhood perennial allergic rhinitis with subclinical airflow limitation
    G Ciprandi
    Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, University of Genoa, Genoa, Italy
    Clin Exp Allergy 40:398-402. 2010
    ..Recently, it has been evidenced that the duration of AR and mite allergy represent high risks for spirometric impairment in allergic adults...
  60. ncbi request reprint Sublingual immunotherapy affects specific antibody and TGF-beta serum levels in patients with allergic rhinitis
    G Ciprandi
    Semeiotica e Metodologia Medica I, DIMI, University of Genoa, Azienda Ospedaliera Universitaria San Martino, Genoa, Italy
    Int J Immunopathol Pharmacol 22:1089-96. 2009
    ..Moreover, this is the first study that measured Ig classes by using a quantitative method...
  61. doi request reprint Serum resistin in persistent allergic rhinitis: preliminary data in adults
    Giorgio Ciprandi
    Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, University of Genoa, Genoa, Italy
    Int Immunopharmacol 10:371-2. 2010
    ..However, that study was conducted in children. Therefore, the present study aimed at confirming these findings also in adult patients with persistent allergic rhinitis (PER)...
  62. doi request reprint Serum adiponectin levels in patients with seasonal allergic rhinitis
    Giorgio Ciprandi
    Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino University of Genoa, Genoa, Italy
    Int Immunopharmacol 10:635-8. 2010
    ..A single study reported that males with seasonal allergic rhinitis (SAR), evaluated outside the pollen season, had increased serum adiponectin levels...
  63. ncbi request reprint Peripheral TH-17 cells in children with allergic rhinitis: preliminary report
    G Ciprandi
    Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino and University of Genoa, Genoa, Italy
    Int J Immunopathol Pharmacol 23:379-82. 2010
    ..In particular, there is a subset co-expressing IL-17 and IFN-gamma both for CD4+ and CD8+ cells. In conclusion, this preliminary study suggests a possible role of Th-17 cells in the response to allergens in children...
  64. ncbi request reprint Rupatadine improves nasal symptoms, airflow and inflammation in patients with persistent allergic rhinitis: a pilot study
    Giorgio Ciprandi
    Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, University of Genoa, Genoa, Italy
    J Biol Regul Homeost Agents 24:177-83. 2010
    ..These positive results could explain the effectiveness of rupatadine in the treatment of persistent allergic rhinitis, as reported in a previous study Further controlled studies need to be conducted to confirm these preliminary findings...
  65. doi request reprint Lower airways may also be affected in asymptomatic patients with recent onset of allergic rhinitis
    Giorgio Ciprandi
    Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino University of Genoa, Genoa, Italy
    Laryngoscope 120:1288-91. 2010
    ..The aim of this study was to investigate the presence of possible spirometric abnormalities and bronchial hyperreactivity (BHR) in a large group of patients with recent onset of AR...
  66. doi request reprint Sublingual immunotherapy in children with allergic polysensitization
    Giorgio Ciprandi
    Dipartimento Medicina Interna, Az Osp Universitaria San Martino, Genoa, Italy
    Allergy Asthma Proc 31:227-31. 2010
    ..This open study provides evidence that polysensitization is not an obstacle for prescribing SLIT in polysensitized children. Indeed, SLIT efficacy on clinical parameters is significant after 1 year and the therapy is safe...
  67. doi request reprint Serum vascular endothelial growth factor and sublingual immunotherapy
    G Ciprandi
    Ospedale San Martino, Largo R Benzi 10, 16132 Genoa, Italy
    Allergy 63:945-6. 2008
  68. ncbi request reprint Nasal airflow recovery after decongestion test is associated with bronchial hyperreactivity in patients with allergic rhinitis
    Giorgio Ciprandi
    Azienda Ospedaliera Universitaria San Martino, Genoa, Italy
    Otolaryngol Head Neck Surg 134:255-9. 2006
    ..The decongestion test involves spraying an intranasal vasoconstrictor drug to evaluate the recovery of nasal airflow...
  69. ncbi request reprint Association between response to decongestion testing and sensitizations and allergic inflammation
    Giorgio Ciprandi
    Dipartimento Patologie Testa Collo, Padiglione Specialità piano terzo, Azienda Ospedale Università San Martino, Genoa, Italy
    Ann Allergy Asthma Immunol 96:431-6. 2006
    ..Rhinomanometry is used to measure nasal airflow, which is frequently impaired in allergic rhinitis (AR). Decongestion testing consists of spraying an intranasal vasoconstrictor drug to evaluate recovery of nasal airflow...
  70. ncbi request reprint Sublingual immunotherapy-induced IL-10 production is associated with changed response to the decongestion test: preliminary results
    Giorgio Ciprandi
    A O U San Martino, Genoa, Italy
    Allergy Asthma Proc 28:574-7. 2007
    ..0016 and p = 0.00294, respectively). This preliminary study provides the first evidence of a changed response to decongestion testing after SLIT that is associated with IL-10 production in patients with PAR...
  71. ncbi request reprint Allergen-specific immunotherapy: an update on immunological mechanisms of action
    G Ciprandi
    Dipartimento Patologie Testa Collo, Azienda Ospedaliera Universitaria San Martino, Genova, Italy
    Monaldi Arch Chest Dis 65:34-7. 2006
    ..SIT is able of inducing a specific Treg response. Sublingual immunotherapy is an alternative route of administration for SIT. Recent evidence shows that SLIT is also able of inducing a Treg response as detected by IL-10 production...
  72. ncbi request reprint Ebastine improves nasal symptoms and airflow and affects response to decongestion test in patients with persistent allergic rhinitis: a pilot study
    Giorgio Ciprandi
    Azienda Ospedaliera Universitaria San Martino, Genoa, Italy
    Allergy Asthma Proc 28:578-81. 2007
    ..However, this pilot study was not suitable in assessing the effectiveness of ebastine on nasal symptoms. Additional controlled studies need to be conducted to confirm these findings...
  73. ncbi request reprint Quality of life in allergic rhinitis: relationship with clinical, immunological, and functional aspects
    G Ciprandi
    Dipartimento di Medicina Interna, Azienda Ospedaliera Universitaria San Martino, Genoa, Italy
    Clin Exp Allergy 37:1528-35. 2007
    ..Moreover, quality of life (QoL) has been widely evaluated in AR and its evaluation is considered in numerous trials...
  74. ncbi request reprint Nasal eosinophils and reversibility to the decongestion test in patients with perennial allergic rhinitis
    Giorgio Ciprandi
    Azienda Ospedaliera Universitaria San Martino, Genoa, Italy
    Allergy Asthma Proc 28:292-5. 2007
    ..338). This study provides evidence of a significant association between nasal eosinophils and the reversibility to the decongestion test in patients with PAR...
  75. ncbi request reprint Sublingual immunotherapy: an update on immunologic and functional effects
    Giorgio Ciprandi
    University Hospital San Martino, Genoa, Italy
    Allergy Asthma Proc 28:40-3. 2007
    ..SLIT should be able to induce a specific T-reg. response. SLIT is an alternative route of administration for SIT. Recent evidence shows that SLIT is also able to induce a T-reg. response as detected by IL-10 production...
  76. ncbi request reprint Role of FEF25-75 as an early marker of bronchial impairment in patients with seasonal allergic rhinitis
    Giorgio Ciprandi
    Azienda Ospedaliera Universitaria San Martino, Genoa, Italy
    Am J Rhinol 20:641-7. 2006
    ..The aim of this study was to evaluate whether patients with seasonal allergic rhinitis (SAR) without symptoms of asthma might, nevertheless, have airways obstruction both in and out of the pollen season...
  77. ncbi request reprint The lower airway pathology of rhinitis
    Giorgio Ciprandi
    Azienda Ospedaliera Universitaria San Martino, Genoa, Italy
    J Allergy Clin Immunol 118:1105-9. 2006
    ..Taking these facts into consideration, a new diagnostic approach should be considered in managing patients with AR: a possible bronchial involvement must be sought in each patient...
  78. ncbi request reprint Sublingual immunotherapy induces spirometric improvement associated with IL-10 production: preliminary reports
    Giorgio Ciprandi
    Azienda Ospedaleria Universitaria San Martino, Largo R Benzi 10, 16132 Genoa, Italy
    Int Immunopharmacol 6:1370-3. 2006
    ..Forced expiratory flow between 25% and 75% of the vital capacity (FEF(25-75)) may be considered a good marker of early bronchial involvement in patients with pure allergic rhinitis...
  79. ncbi request reprint Early bronchial airflow impairment in patients with persistent allergic rhinitis and bronchial hyperreactivity
    Giorgio Ciprandi
    Head Neck Dpt, San Martino Hospital, Genoa, Italy
    Respir Med 99:1606-12. 2005
    ..Allergic rhinitis and its impact on asthma (ARIA) document underlines the link between upper and lower airways. Patients suffering from allergic rhinitis frequently (up to 80%) show bronchial hyperreactivity (BHR)...
  80. doi request reprint Relationship between rhinitis duration and worsening of nasal function
    Giorgio Ciprandi
    Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, Genoa, Italy
    Otolaryngol Head Neck Surg 138:725-9. 2008
    ..While it is well known that asthma is characterized by airway remodeling, few studies instead have investigated this issue in patients with allergic rhinitis (AR)...
  81. ncbi request reprint Serum vascular endothelial growth factor in allergic rhinitis and systemic lupus erythematosus
    Giorgio Ciprandi
    Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, University of Genoa, Genoa, Italy
    Hum Immunol 69:510-2. 2008
    ..The relevance of this phenomenon is further apparent, as it is also observed in patients with inactive disease...
  82. ncbi request reprint Bronchial hyperreactivity and spirometric impairment in patients with perennial allergic rhinitis
    Giorgio Ciprandi
    Allergy, Head and Neck Department, San Martino Hospital, Genoa, Italy
    Int Arch Allergy Immunol 133:14-8. 2004
    ..Smaller airways may also be impaired in mild asthma. This study aimed at evaluating a group of subjects suffering from perennial allergic rhinitis alone to investigate the presence of BHR and spirometric impairment...
  83. ncbi request reprint The effect of budesonide on the cytokine pattern in patients with perennial allergic rhinitis
    Giorgio Ciprandi
    Allergologia U O ORL, Dipartimento Regionale Testa Collo, Padiglione Specialità piano terzo, Ospedale San Martino, Genoa, Italy
    Ann Allergy Asthma Immunol 91:467-71. 2003
    ..A T(H)2-polarized cytokine pattern has been demonstrated in allergic rhinitis. Budesonide represents an effective topical corticosteroid in the management of allergic rhinitis...
  84. ncbi request reprint Levocetirizine improves nasal obstruction and modulates cytokine pattern in patients with seasonal allergic rhinitis: a pilot study
    G Ciprandi
    Allergologia, Ospedale San Martino, Genoa, Italy
    Clin Exp Allergy 34:958-64. 2004
    ..Allergic rhinitis is characterized by an IgE-dependent inflammation. Nasal obstruction is related to allergic inflammation. Some antihistamines have been demonstrated to be capable of improving this nasal symptom...
  85. ncbi request reprint Bronchial hyperreactivity and spirometric impairment in patients with seasonal allergic rhinitis
    Giorgio Ciprandi
    Dipartimento Regionale Testa Collo, Padiglione Specialità piano terzo, Ospedale San Martino, Largo R Benzi 10, Genoa 16132, Italy
    Respir Med 98:826-31. 2004
    ..Thus, the present study aimed at evaluating a group of subjects suffering from seasonal allergic rhinitis alone to investigate the presence of spirometric impairment and BHR both during and outside the pollen season...
  86. ncbi request reprint Sublingual immunotherapy and regulatory T cells
    G Ciprandi
    Dipartimento Patologie Testa Collo, Padiglione Specialità piano terzo, Ospedale San Martino, Largo R Benzi 10, 16132 Genoa, Italy
    Allergy 61:511-3. 2006
  87. ncbi request reprint Correlation of nasal inflammation and nasal airflow with forced expiratory volume in 1 second in patients with perennial allergic rhinitis and asthma
    Giorgio Ciprandi
    Head Neck Department, Ospedale San Martino, Genoa, Italy
    Ann Allergy Asthma Immunol 93:575-80. 2004
    ..Allergic rhinitis and asthma are frequently associated and are characterized by TH2-dependent inflammation. Nasal and bronchial obstruction largely depend on allergic inflammation...
  88. ncbi request reprint Bacillus clausii effects in children with allergic rhinitis
    G Ciprandi
    Allergologia U O ORL, Padiglione Specialità piano terzo, Ospedale San Martino, Largo R Benzi 10, 16132 Genoa, Italy
    Allergy 60:702-3. 2005
  89. ncbi request reprint Induction of interleukin 10 by sublingual immunotherapy for house dust mites: a preliminary report
    Giorgio Ciprandi
    Dipartimento Regionale Testa Collo, Azienda Ospedale Università San Martino, Genoa, Italy
    Ann Allergy Asthma Immunol 95:38-44. 2005
    ..Interleukin 10 (IL-10) plays a crucial role in inducing allergen-specific tolerance; however, no previous studies have examined IL-10 production after sublingual immunotherapy (SLIT)...
  90. ncbi request reprint Allergic children have more numerous and severe respiratory infections than non-allergic children
    Giorgio Ciprandi
    Azienda Ospedaliera Universitaria San Martino, Genova, Italy
    Pediatr Allergy Immunol 17:389-91. 2006
    ..94 +/- 1.37 and 4.85 days) (p = 0.0001 and p = 0.009, respectively). In conclusion, this study provides the evidence that allergic children have more numerous and severe RI than non-allergic children...
  91. doi request reprint Relationship between bronchial hyperreactivity and bronchodilation in patients with allergic rhinitis
    Giorgio Ciprandi
    Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, Genoa, Italy
    Ann Allergy Asthma Immunol 106:460-6. 2011
    ..Moreover, bronchial hyperreactivity (BHR) is frequently detected in AR patients...
  92. ncbi request reprint Cetirizine reduces cytokines and inflammatory cells in children with perennial allergic rhinitis
    G Ciprandi
    Allergy and ENT Division, Head Neck Dpt, San Martino Hospital, Genoa
    Eur Ann Allergy Clin Immunol 36:237-40. 2004
    ..007). This study shows the cetirizine effectiveness in exerting anti-inflammatory activity by modulating cytokine pattern and by reducing inflammatory infiltration in children with perennial allergic rhinitis...
  93. ncbi request reprint Intranasal mometasone furoate reduces late-phase inflammation after allergen challenge
    G Ciprandi
    Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Italy
    Ann Allergy Asthma Immunol 86:433-8. 2001
    ..Topical corticosteroids have been accepted as a highly effective anti-inflammatory therapy for allergic rhinitis...
  94. ncbi request reprint Sublingual specific immunotherapy reduces PBMC proliferations
    D Fenoglio
    DIMI CEBR, Universita di Genova, Genoa, Italy
    Eur Ann Allergy Clin Immunol 37:147-51. 2005
    ..Subcutaneous specific immunotherapy has been demonstrated capable of inducing T regulatory response. There is few evidence concerning immunological changes induced by sublingual immunotherapy...
  95. ncbi request reprint Characteristics of patients with allergic polysensitization: the POLISMAIL study
    G Ciprandi
    Dipartimento Medicina Interna, Az Osp Universitaria San Martino, Genoa, Italy
    Eur Ann Allergy Clin Immunol 40:77-83. 2008
    ..The polysensitization phenomenon starts since childhood and is rare to find monosensitized adult patients. However, there are few studies investigating the characteristics of polysensitized patients...
  96. ncbi request reprint Nasal eosinophils correlate with FEV1 in patients with perennial allergic rhinitis associated to asthma
    G Ciprandi
    Allergologia, UO ORL, Dipartimento Testa Collo, Ospedale San Martino, Genova, Italy
    Eur Ann Allergy Clin Immunol 36:363-5. 2004
    ..Our aim was to evaluate whether nasal inflammation correlates with lung function in patients with perennial allergic rhinitis associated with asthma...
  97. ncbi request reprint Levocetirizine improves nasal symptoms and airflow in patients with persistent allergic rhinitis: a pilot study
    G Ciprandi
    Ospedale San Martino, Genoa, Italy
    Eur Ann Allergy Clin Immunol 37:25-9. 2005
    ..The aim of this pilot study was to evaluate nasal symptoms, nasal airflow, and decongestent activity in patients with persistent allergic rhinitis, before and after treatment with levocetirizine or placebo...
  98. pmc Allergy and the lung
    G Passalacqua
    Allergy and Respiratory Diseases, Department of Internatl Medicine, San Martino Hospital, Padigliano Maragliano, Italy
    Clin Exp Immunol 153:12-6. 2008
    ..The recent introduction of biological treatments (monoclonal antibodies) has allowed elucidation of some of the pathogenic features of allergic asthma...