S Cinti

Summary

Country: Italy

Publications

  1. doi request reprint Between brown and white: novel aspects of adipocyte differentiation
    Saverio Cinti
    Department of Molecular Pathology and Innovative Therapies, Faculty of Medicine, University of Ancona Politecnica delle Marche, Ancona, Italy
    Ann Med 43:104-15. 2011
  2. ncbi request reprint The adipose organ
    S Cinti
    University of Ancona, Italy, European Union
    Prostaglandins Leukot Essent Fatty Acids 73:9-15. 2005
  3. doi request reprint Reversible physiological transdifferentiation in the adipose organ
    Saverio Cinti
    Department of Molecular Pathology and Innovative Therapies, University of Ancona Politecnica delle Marche, 60020 Ancona, Italy
    Proc Nutr Soc 68:340-9. 2009
  4. pmc Endothelial cells of adipose tissues: A niche of adipogenesis
    Andrea Frontini
    Department of Experimental and Clinical Medicine University of Ancona Politecnica delle Marche Ancona, Italy
    Cell Cycle 11:2765-6. 2012
  5. pmc The adipose organ at a glance
    Saverio Cinti
    Department of Experimental and Clinical Medicine, Azienda Ospedali Riuniti University of Ancona Politecnica delle Marche, 60020 Ancona, Italy
    Dis Model Mech 5:588-94. 2012
  6. ncbi request reprint The role of brown adipose tissue in human obesity
    Saverio Cinti
    Institute of Normal Human Morphology, University of Ancona, Via Tronto 10 A, 60020 Ancona, Italy
    Nutr Metab Cardiovasc Dis 16:569-74. 2006
  7. doi request reprint Transdifferentiation properties of adipocytes in the adipose organ
    Saverio Cinti
    Faculty of Medicine, Univ of Ancona Politecnica delle Marche Via Tronto 10a, 60020 Ancona, Italy
    Am J Physiol Endocrinol Metab 297:E977-86. 2009
  8. doi request reprint The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation
    G Barbatelli
    Department of Molecular Pathology and Innovative Therapies, Faculty of Medicine, University of Ancona Politecnica delle Marche, Ancona, Italy
    Am J Physiol Endocrinol Metab 298:E1244-53. 2010
  9. ncbi request reprint Adipose tissues and obesity
    S Cinti
    Institute of Normal Human Morphology Anatomy, School of Medicine, University of Ancona, Italy
    Ital J Anat Embryol 104:37-51. 1999
  10. pmc The adipose organ of obesity-prone C57BL/6J mice is composed of mixed white and brown adipocytes
    A Vitali
    Department of Experimental and Clinical Medicine, University of Ancona, Politecnica delle Marche, 60020 Ancona, Italy
    J Lipid Res 53:619-29. 2012

Collaborators

Detail Information

Publications63

  1. doi request reprint Between brown and white: novel aspects of adipocyte differentiation
    Saverio Cinti
    Department of Molecular Pathology and Innovative Therapies, Faculty of Medicine, University of Ancona Politecnica delle Marche, Ancona, Italy
    Ann Med 43:104-15. 2011
    ..The critical death size of visceral adipocytes is smaller than that of subcutaneous adipocytes, likely accounting for the greater morbidity related to visceral fat...
  2. ncbi request reprint The adipose organ
    S Cinti
    University of Ancona, Italy, European Union
    Prostaglandins Leukot Essent Fatty Acids 73:9-15. 2005
    ..All together these experiments strongly suggest the possibility to modulate the plasticity of the adipose organ with therapeutic implications for obesity and related disorders...
  3. doi request reprint Reversible physiological transdifferentiation in the adipose organ
    Saverio Cinti
    Department of Molecular Pathology and Innovative Therapies, University of Ancona Politecnica delle Marche, 60020 Ancona, Italy
    Proc Nutr Soc 68:340-9. 2009
    ..These findings, if confirmed, seem to suggest new windows into the cell biology frontiers of adipocytes...
  4. pmc Endothelial cells of adipose tissues: A niche of adipogenesis
    Andrea Frontini
    Department of Experimental and Clinical Medicine University of Ancona Politecnica delle Marche Ancona, Italy
    Cell Cycle 11:2765-6. 2012
    ..Comment on: Tran KV, et al. Cell Metab 2012; 15:222-9...
  5. pmc The adipose organ at a glance
    Saverio Cinti
    Department of Experimental and Clinical Medicine, Azienda Ospedali Riuniti University of Ancona Politecnica delle Marche, 60020 Ancona, Italy
    Dis Model Mech 5:588-94. 2012
    ....
  6. ncbi request reprint The role of brown adipose tissue in human obesity
    Saverio Cinti
    Institute of Normal Human Morphology, University of Ancona, Via Tronto 10 A, 60020 Ancona, Italy
    Nutr Metab Cardiovasc Dis 16:569-74. 2006
    ..In this paper these new concepts will be explained together with a review of available scientific data on human BAT...
  7. doi request reprint Transdifferentiation properties of adipocytes in the adipose organ
    Saverio Cinti
    Faculty of Medicine, Univ of Ancona Politecnica delle Marche Via Tronto 10a, 60020 Ancona, Italy
    Am J Physiol Endocrinol Metab 297:E977-86. 2009
    ....
  8. doi request reprint The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation
    G Barbatelli
    Department of Molecular Pathology and Innovative Therapies, Faculty of Medicine, University of Ancona Politecnica delle Marche, Ancona, Italy
    Am J Physiol Endocrinol Metab 298:E1244-53. 2010
    ..Overall, our data strongly suggest that the cold-induced emergence of brown adipocytes in WAT predominantly reflects beta(3)-adrenoceptor-mediated transdifferentiation...
  9. ncbi request reprint Adipose tissues and obesity
    S Cinti
    Institute of Normal Human Morphology Anatomy, School of Medicine, University of Ancona, Italy
    Ital J Anat Embryol 104:37-51. 1999
    ..These basic mechanisms should be taken into account when addressing the physiopathology of obesity and its treatment...
  10. pmc The adipose organ of obesity-prone C57BL/6J mice is composed of mixed white and brown adipocytes
    A Vitali
    Department of Experimental and Clinical Medicine, University of Ancona, Politecnica delle Marche, 60020 Ancona, Italy
    J Lipid Res 53:619-29. 2012
    ..However, the greater C57BL/6J browning capacity can hopefully be harnessed to curb obesity and type 2 diabetes in patients with constitutively low amounts of brown adipose tissue...
  11. ncbi request reprint The adipose organ: morphological perspectives of adipose tissues
    S Cinti
    Institute of Normal Human Morphology Anatomy, Faculty of Medicine, University of Ancona, Via Tronto, Italy
    Proc Nutr Soc 60:319-28. 2001
    ..These basic mechanisms should be taken into account when addressing the physiopathology of obesity and its treatment...
  12. pmc Noradrenergic parenchymal nerve fiber branching after cold acclimatisation correlates with brown adipocyte density in mouse adipose organ
    I Murano
    Institute of Normal Human Morphology, University of Ancona Politecnica delle Marche, Ancona, Italy
    J Anat 214:171-8. 2009
    ..Taken together, these data suggest that cold acclimatisation induces noradrenergic fiber branching in the adipose organ of adult mice, and that such changes may be a precondition for its plastic transformation into a brown phenotype...
  13. doi request reprint The adipose organ: white-brown adipocyte plasticity and metabolic inflammation
    A Smorlesi
    Department of Experimental and Clinical Medicine, University of Ancona Politecnica delle Marche, Via Tronto 10 A, Ancona, Italy
    Obes Rev 13:83-96. 2012
    ..Thus, a better understanding of the molecular mechanisms at the basis of white-brown transdifferentiation can be extremely useful to exploit new therapeutic strategies to combat the increasing incidence of metabolic diseases...
  14. pmc Time course of histomorphological changes in adipose tissue upon acute lipoatrophy
    I Murano
    Dpt Experimental and Clinical Medicine, University of Ancona, Politecnica delle Marche, Electron Microscopy Unit Azienda Ospedali Riuniti, Ancona, Italy
    Nutr Metab Cardiovasc Dis 23:723-31. 2013
    ..In this "FAT ATTAC" model, apoptosis is induced through forced dimerization of a caspase-8 fusion protein...
  15. ncbi request reprint Expression and distribution of heme oxygenase-1 and -2 in rat brown adipose tissue: the modulatory role of the noradrenergic system
    A Giordano
    Institute of Normal Human Morphology Anatomy, Faculty of Medicine, University of Ancona, Italy
    FEBS Lett 487:171-5. 2000
    ....
  16. ncbi request reprint Sema3a is produced by brown adipocytes and its secretion is reduced following cold acclimation
    A Giordano
    Institute of Normal Human Morphology-Anatomy, Faculty of Medicine, University of Ancona, Via Tronto 10/A, 60020 Ancona, Italy
    J Neurocytol 30:5-10. 2001
    ..Thus, Sema3a could play a role in the plastic adjustment of BAT innervation observed in different conditions of functional demand...
  17. ncbi request reprint Unusual ultrastructural features in microvillous inclusion disease: A report of two cases
    Manrico Morroni
    Institute of Normal Human Morphology, Faculty of Medicine, Polytechnic University of Marche, Ancona, Italy
    Virchows Arch 448:805-10. 2006
    ..In one MID specimen, immature gc were also identified in the absorptive compartment. Only mature gc were observed in the controls. The significance of the latter finding requires further studies...
  18. pmc Brush cells in the human duodenojejunal junction: an ultrastructural study
    Manrico Morroni
    Institute of Normal Human Morphology, School of Medicine, Polytechnic University of Marche, Ancona, Italy
    J Anat 211:125-31. 2007
    ..The observation of nerve fibres closely associated with brush cells, never previously described in humans, lends support to the hypothesis of a receptor role for these cells...
  19. pmc Increased density of inhibitory noradrenergic parenchymal nerve fibers in hypertrophic islets of Langerhans of obese mice
    I Giannulis
    Dpt of Experimental and Clinical Medicine, Obesity Center, University of Ancona Politecnica delle Marche and Azienda Ospedali Riuniti, 60020 Ancona, Italy
    Nutr Metab Cardiovasc Dis 24:384-92. 2014
    ..We analyzed genetically obese ob/ob and db/db mice at different ages (6- and 15-week-old), corresponding to different compensatory stages in the course of beta cell dysfunction. 15 week-old HFD mice were also studied...
  20. ncbi request reprint Adipocyte differentiation and transdifferentiation: plasticity of the adipose organ
    S Cinti
    Institute of Normal Human Morphology, Faculty of Medicine, University of Ancona, Ancona, Italy
    J Endocrinol Invest 25:823-35. 2002
    ..The ability of the adipose organ to interconvert its main cytotypes in order to meet changing metabolic needs is highly pertinent to the physiopathology of obesity and related to therapeutic strategies...
  21. doi request reprint Morphological and immunohistochemical features of brown adipocytes and preadipocytes in a case of human hibernoma
    M Manieri
    Department of Molecular Pathology and Innovative Therapies, School of Medicine, University of Ancona, Politecnica delle Marche, Via Tronto 10 A, 60020 Ancona, Italy
    Nutr Metab Cardiovasc Dis 20:567-74. 2010
    ..The role of brown adipose tissue physiology and pathology in humans is debated. A greater knowledge of its developmental aspects could play a pivotal role in devising treatments for obesity and diabetes...
  22. ncbi request reprint Sibutramine-dependent brown fat activation in rats: an immunohistochemical study
    A Giordano
    Institute of Normal Human Morphology Anatomy, Faculty of Medicine, University of Ancona, Ancona, Italy
    Int J Obes Relat Metab Disord 26:354-60. 2002
    ....
  23. ncbi request reprint Secretory granules of endocrine and chief cells of human stomach mucosa contain leptin
    S Cinti
    Institute of Normal Human Morphology Anatomy, University of Ancona, 60020 Ancona, Italy
    Int J Obes Relat Metab Disord 24:789-93. 2000
    ..In humans, leptin is produced by adipocytes, placental cells and secretory cells of the mammary epithelium. Recently, it has been reported that stomach glands produce leptin in rats...
  24. pmc In vivo leptin expression in cartilage and bone cells of growing rats and adult humans
    M Morroni
    Istituto di Morfologia Umana Normale, Universita Politecnica delle Marche, Ancona, Italy
    J Anat 205:291-6. 2004
    ....
  25. ncbi request reprint Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice
    I Murano
    Institute of Normal Human Morphology, University of Ancona Politecnica delle Marche, Ancona, Italy
    J Lipid Res 49:1562-8. 2008
    ..Visceral fat CLS density was 3.4-fold greater in db/db than in ob/ob animals, which at the age at which our experimental strain was used are more prone to glucose metabolic disorders...
  26. ncbi request reprint Immunohistochemical identification of the beta(3)-adrenoceptor in intact human adipocytes and ventricular myocardium: effect of obesity and treatment with ephedrine and caffeine
    R De Matteis
    Institute of Normal Human Morphology Anatomy, University of Ancona, Ancona, Italy
    Int J Obes Relat Metab Disord 26:1442-50. 2002
    ....
  27. pmc Reversible transdifferentiation of secretory epithelial cells into adipocytes in the mammary gland
    Manrico Morroni
    Institute of Anatomy, School of Medicine, University of Ancona, Via Tronto 10 A, 60020 Ancona, Italy
    Proc Natl Acad Sci U S A 101:16801-6. 2004
    ..We conclude that reversible adipocyte-to-epithelium and epithelium-to-adipocyte transdifferentiation occurs in the mammary gland of adult mice during pregnancy and lactation...
  28. doi request reprint In vivo physiological transdifferentiation of adult adipose cells
    Rita De Matteis
    Department of Molecular Pathology and Innovative Therapies, Faculty of Medicine, University of Ancona Politecnica delle Marche, 60020 Ancona, Italy
    Stem Cells 27:2761-8. 2009
    ....
  29. pmc Low FasL levels promote proliferation of human bone marrow-derived mesenchymal stem cells, higher levels inhibit their differentiation into adipocytes
    M R Rippo
    Laboratory of Experimental Pathology, Department of Clinical and Molecular Sciences, Universita Politecnica delle Marche, Ancona, Italy
    Cell Death Dis 4:e594. 2013
    ....
  30. ncbi request reprint Hairy cell leukemia: an ultrastructural study of hairy cells before and after interferon therapy
    M Morroni
    Institute of Normal Human Morphology, Faculty of Medicine, University of Ancona - U.S.L. 12, Italy
    Tumori 81:249-55. 1995
    ....
  31. pmc Intralobular ducts of human major salivary glands contain leptin and its receptor
    R De Matteis
    Institute of Normal Human Morphology Anatomy, University of Ancona, Italy
    J Anat 201:363-70. 2002
    ..Co-localization for leptin, leptin receptor and glucocorticoid receptor in the same cell type suggested a functional relationship between glucocorticoid hormone and leptin secretion also at the level of the salivary glands...
  32. doi request reprint The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue
    Maria Cristina Zingaretti
    Department of Molecular Pathology and Innovative Therapies, Faculty of Medicine, Ospedali Riuniti Ancona, University of Ancona Politecnica delle Marche, Ancona, Italy
    FASEB J 23:3113-20. 2009
    ....
  33. ncbi request reprint CL316,243 and cold stress induce heterogeneous expression of UCP1 mRNA and protein in rodent brown adipocytes
    Saverio Cinti
    Institute of Normal Human Morphology, Faculty of Medicine, University of Ancona, Italy
    J Histochem Cytochem 50:21-31. 2002
    ..Of note, the heat shock protein heme oxygenase 1 (HO1) is heterogeneously expressed in adrenergically stimulated brown adipose tissue and, specifically, cells expressing strong immunoreactivity for UCP1 also strongly express HO1...
  34. ncbi request reprint Thymus uncoupling protein 1 is exclusive to typical brown adipocytes and is not found in thymocytes
    Andrea Frontini
    Institute of Normal Human Morphology, Marche Polytechnic University, Via Tronto, 10 A, 60020 Ancona, Italy
    J Histochem Cytochem 55:183-9. 2007
    ..Whether brown adipocytes adjacent to thymic lobes play a role in thymus physiology remains to be investigated...
  35. ncbi request reprint Evidence for a functional nitric oxide synthase system in brown adipocyte nucleus
    Antonio Giordano
    Institute of Normal Human Morphology, Faculty of Medicine, University of Ancona, Ancona, Italy
    FEBS Lett 514:135-40. 2002
    ..These data suggest the existence of a noradrenaline-modulated functional NOS system in the nucleus of brown adipocytes...
  36. doi request reprint Distribution and development of brown adipocytes in the murine and human adipose organ
    Andrea Frontini
    Department of Molecular Pathology and Innovative Therapies, University of Ancona Politecnica delle Marche, IT 60020 Ancona, Italy
    Cell Metab 11:253-6. 2010
    ..Many of the anatomo-physiological features of murine fat depots apply to humans...
  37. ncbi request reprint Sema3A and neuropilin-1 expression and distribution in rat white adipose tissue
    Antonio Giordano
    Institute of Normal Human Morphology, Marche Polytechnic University, Ancona, Italy
    J Neurocytol 32:345-52. 2003
    ..Finally, the presence of neuropilin-1 in some white adipocytes raises the interesting possibility that Sema3A also exerts an autocrine-paracrine role on these cells...
  38. doi request reprint Adipose organ nerves revealed by immunohistochemistry
    Antonio Giordano
    Institute of Normal Human Morphology, School of Medicine, Marche Polytechnic University, Via Tronto, 10 A, 60020 Ancona, Italy
    Methods Mol Biol 456:83-95. 2008
    ..With these techniques, the presence, distribution, and colocalization of autonomic and sensory nerves can be effectively investigated in subcutaneous and visceral adipose depots of normal and obese animals...
  39. doi request reprint Leptin-dependent STAT3 phosphorylation in postnatal mouse hypothalamus
    Andrea Frontini
    Institute of Normal Human Morphology, Marche Polytechnic University, Via Tronto 10 A, 60020 Ancona, Italy
    Brain Res 1215:105-15. 2008
    ..These cells did not express mature or immature neuronal or glial markers. Their ultrastructural appearance, though suggestive of differentiating cells, was not conclusive for a specific phenotype...
  40. ncbi request reprint Regional-dependent increase of sympathetic innervation in rat white adipose tissue during prolonged fasting
    Antonio Giordano
    Institute of Normal Human Morphology, Marche Polytechnic University, Via Tronto, 10 A, 60020 Ancona, Italy
    J Histochem Cytochem 53:679-87. 2005
    ....
  41. ncbi request reprint Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
    Saverio Cinti
    Institute of Normal Human Morphology, University of Ancona, Ancona, Italy
    J Lipid Res 46:2347-55. 2005
    ..These results provide a novel framework for understanding macrophage recruitment, function, and persistence in WAT of obese individuals...
  42. ncbi request reprint Morphology of ferret subcutaneous adipose tissue after 6-month daily supplementation with oral beta-carotene
    Incoronata Murano
    Istituto di Morfologia Umana Normale, University of Ancona, Ancona, Italy
    Biochim Biophys Acta 1740:305-12. 2005
    ..We also found focally evident liver steatosis in the ferrets treated with the higher dose of beta-carotene. The other gastrointestinal tract organs studied were not significantly different from those of control animals...
  43. ncbi request reprint Remodeling of white adipose tissue after retinoic acid administration in mice
    Josep Mercader
    Laboratory of Molecular Biology, Nutrition and Biotechnology, University of the Balearic Islands, 07122 Palma de Mallorca, Spain
    Endocrinology 147:5325-32. 2006
    ..Understanding the mechanisms and effectors involved in the remodeling of WAT can contribute to new avenues of prevention and treatment of obesity and type 2 diabetes...
  44. pmc Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation
    Jacob B Hansen
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK 5230 Odense M, Denmark
    Proc Natl Acad Sci U S A 101:4112-7. 2004
    ..We propose that pRB acts as a molecular switch determining white vs. brown adipogenesis, suggesting a previously uncharacterized function of this key cell cycle regulator in adipocyte lineage commitment and differentiation...
  45. ncbi request reprint Expression of the uncoupling protein 1 from the aP2 gene promoter stimulates mitochondrial biogenesis in unilocular adipocytes in vivo
    Martin Rossmeisl
    Department of Adipose Tissue Biology and Center for Integrated Genomics, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Eur J Biochem 269:19-28. 2002
    ..Our results indicate that respiratory uncoupling in unilocular adipocytes of white fat is capable of both inducing mitochondrial biogenesis and reducing development of obesity...
  46. ncbi request reprint Decreased brown adipocyte recruitment and thermogenic capacity in mice with impaired peroxisome proliferator-activated receptor (P465L PPARgamma) function
    Sarah L Gray
    Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QR, United Kingdom
    Endocrinology 147:5708-14. 2006
    ....
  47. ncbi request reprint Mitochondrial proton leak in obesity-resistant and obesity-prone mice
    Brian D Fink
    University of Iowa, Iowa City Veterans Affairs Medical Center, Iowa City, IA 52242, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1773-80. 2007
    ..But, this is only achieved only at a higher body mass and, therefore, may be adaptive rather than preventative. Neither obesity-prone nor resistant mice respond to HF feeding by expressing more UCP1 in ectopic BAT within muscle tissue...
  48. ncbi request reprint Obesity modulates the expression of haptoglobin in the white adipose tissue via TNFalpha
    Chiara Chiellini
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    J Cell Physiol 190:251-8. 2002
    ..These results demonstrate that haptoglobin expression in WAT is increased in obesity in rodents and TNFalpha is an important signal for this regulation...
  49. ncbi request reprint Beta 3-adrenoceptor knockout in C57BL/6J mice depresses the occurrence of brown adipocytes in white fat
    Maria Jimenez
    D├ępartement de Biochimie M├ędicaleet Physiologie, Centre Medical Universitaire, Geneva, Switzerland
    Eur J Biochem 270:699-705. 2003
    ..These results indicate that beta 3-adrenoceptors play a major role in the appearance of brown adipocytes in white fat and suggest that the brown adipocytes present in white fat differ from those in brown fat...
  50. ncbi request reprint betaAR signaling required for diet-induced thermogenesis and obesity resistance
    Eric S Bachman
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
    Science 297:843-5. 2002
    ..These findings establish that betaARs are necessary for diet-induced thermogenesis and that this efferent pathway plays a critical role in the body's defense against diet-induced obesity...
  51. ncbi request reprint Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss
    Raffaella Cancello
    INSERM Avenir, Paris 6 University EA3502 and Human Research Center on Nutrition CRNH, Hotel Dieu Hospital, AP HP, Paris, France
    Diabetes 54:2277-86. 2005
    ..We show that improvement of the inflammatory profile after weight loss is related to a reduced number of macrophages in scWAT. MCP-1, PLAUR, CSF-3, and HIF-1alpha may play roles in the attraction of macrophages in scWAT...
  52. ncbi request reprint The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform
    Gema Medina-Gomez
    Department of Clinical Biochemistry, University of Cambridge Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QR, UK
    Diabetes 54:1706-16. 2005
    ....
  53. ncbi request reprint In vivo phenotyping of the ob/ob mouse by magnetic resonance imaging and 1H-magnetic resonance spectroscopy
    Laura Calderan
    Department of Morphological Biomedical Sciences, Human Anatomy and Histology Section, Medical Faculty, University of Verona, Strada Le Grazie 8, 37134, Verona, Italy
    Obesity (Silver Spring) 14:405-14. 2006
    ..We studied ob/ob and wild-type (WT) mice to characterize the adipose tissues depots and other visceral organs and to establish an experimental paradigm for in vivo phenotyping...
  54. ncbi request reprint Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-gamma
    David B Savage
    Department of Medicine, Addenbrooke s Hospital, Cambridge, UK
    Diabetes 52:910-7. 2003
    ..Although the condition is rare, the study of humans with dominant-negative mutations in PPAR-gamma can provide important insight into the roles of this nuclear receptor in human metabolism...
  55. pmc Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance
    Claudia R Vianna
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Cell Metab 4:453-64. 2006
    ..Importantly, these abnormalities do not cause insulin resistance in skeletal muscle but cause substantially reduced insulin action in the liver...
  56. pmc Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice
    Katrine Almind
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 104:2366-71. 2007
    ..Thus, ectopic deposits of brown adipose tissue in intermuscular depots with regulatable expression of UCP1 provide a genetically based mechanism of protection from weight gain and metabolic syndrome between strains of mice...
  57. ncbi request reprint Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice
    Jiandie Lin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 119:121-35. 2004
    ..These data illustrate a central role for PGC-1alpha in the control of energy metabolism but also reveal novel systemic compensatory mechanisms and pathogenic effects of impaired energy homeostasis...
  58. ncbi request reprint The imprinted signaling protein XL alpha s is required for postnatal adaptation to feeding
    Antonius Plagge
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, CB2 4AT, UK
    Nat Genet 36:818-26. 2004
    ..The opposing effects of maternally and paternally expressed products of the Gnas locus provide tangible molecular support for the parental-conflict hypothesis of imprinting...
  59. ncbi request reprint Leptin deficiency unmasks the deleterious effects of impaired peroxisome proliferator-activated receptor gamma function (P465L PPARgamma) in mice
    Sarah L Gray
    Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QR, UK
    Diabetes 55:2669-77. 2006
    ..Thus, adipose tissue expandability is identified as an important factor for the development of insulin resistance in the context of positive energy balance...
  60. ncbi request reprint Presence and distribution of cholinergic nerves in rat mediastinal brown adipose tissue
    Antonio Giordano
    Institute of Normal Human Morphology, Faculty of Medicine, Via Tronto, 10 A, 60020 Ancona, Italy
    J Histochem Cytochem 52:923-30. 2004
    ....
  61. pmc Zinc-alpha2-glycoprotein, a lipid mobilizing factor, is expressed in adipocytes and is up-regulated in mice with cancer cachexia
    Chen Bing
    Neuroendocrine and Obesity Biology Unit, Department of Medicine, University Clinical Departments, University of Liverpool, Liverpool L69 3GA, UK
    Proc Natl Acad Sci U S A 101:2500-5. 2004
    ..Overexpression in WAT of tumor-bearing mice suggests a local role for adipocyte-derived ZAG in the substantial reduction of adiposity of cancer cachexia...
  62. pmc Mosaic analysis of insulin receptor function
    Tadahiro Kitamura
    Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    J Clin Invest 113:209-19. 2004
    ..These findings indicate that insulin regulates growth independently of metabolism and that the number of insulin receptors is an important determinant of the specificity of insulin action...
  63. ncbi request reprint Sensory or sympathetic white adipose tissue denervation differentially affects depot growth and cellularity
    Haifei Shi
    Department Biology, Neurobiology and Behavior Program, Center for Behavioral Neuroscience, Georgia State University, 24 Peachtree Center Ave NE, Atlanta, GA 30302 4010, USA
    Am J Physiol Regul Integr Comp Physiol 288:R1028-37. 2005
    ....