A Ricci

Summary

Affiliation: Chieti-Pescara University
Country: Italy

Publications

  1. ncbi request reprint [Treatment of severe intermittent claudication: ORACLE-PGE1 short term study. A randomised 40-week study. Evaluation of efficacy and costs]
    M R Cesarone
    Dipartimento di Scienze Biomediche, Vascular Lab, Universita di Chieti, Progetto Vascolare San Valentino Pe, ISVI Italian Society for Vascular Investigation, Italy
    Minerva Cardioangiol 50:683-90. 2002
  2. ncbi request reprint Control of edema in hypertensive subjects treated with calcium antagonist (nifedipine) or angiotensin-converting enzyme inhibitors with Pycnogenol
    Gianni Belcaro
    Department of Biomedical Sciences, Irvine2 Vasc Lab, G D Annunzio University
    Clin Appl Thromb Hemost 12:440-4. 2006
  3. doi request reprint O-(beta-hydroxyethyl)-rutosides systemic and local treatment in chronic venous disease and microangiopathy: an independent prospective comparative study
    Gianni Belcaro
    Department of Biomedical Sciences, Chieti Pescara University, and the San Valentino Vascular Screening Project, Italy
    Angiology 59:7S-13S. 2008
  4. doi request reprint 5-Year control and treatment of edema and increased capillary filtration in venous hypertension and diabetic microangiopathy using O-(beta-hydroxyethyl)-rutosides: a prospective comparative clinical registry
    Gianni Belcaro
    Department of Biomedical Sciences, Chieti Pescara University, and the San Valentino Vascular Screening Project, Italy
    Angiology 59:14S-20S. 2008
  5. ncbi request reprint Investigation of Pycnogenol® in combination with coenzymeQ10 in heart failure patients (NYHA II/III)
    G Belcaro
    Irvine3 Labs, Department Biomedical Sciences, Chieti Pescara University, Pescara, Italy
    Panminerva Med 52:21-5. 2010
  6. ncbi request reprint Improvement in signs and symptoms in psoriasis patients with Pycnogenol® supplementation
    G Belcaro
    Irvine 3 Circulation Vascular Labs, Department of Biomedical Sciences, CH PE University, Pescara, Italy
    Panminerva Med 56:41-8. 2014
  7. ncbi request reprint Improved management of primary chronic fatigue syndrome with the supplement French oak wood extract (Robuvit®): a pilot, registry evaluation
    G Belcaro
    Irvine3 Circulation Vascular Labs and San Val Epidemiology Department of Biomedical Sciences, Chieti Pescara University, Pescara, Italy
    Panminerva Med 56:63-72. 2014
  8. ncbi request reprint Robuvit® (French oak wood extract) in the management of functional, temporary hepatic damage. A registry, pilot study
    G Belcaro
    Department of Biomedical Sciences, Irvine3 Labs, Chieti Pescara University, Spoltore, Pescara, Italy
    Minerva Med 105:41-50. 2014
  9. ncbi request reprint Pycnogenol® in postpartum symptomatic hemorrhoids
    G Belcaro
    Irvine3 Circulation Vascular Labs, Nicolaides Lab Department of Biomedical Sciences, Chieti Pescara University, Pescara, Italy
    Minerva Ginecol 66:77-84. 2014
  10. ncbi request reprint Pycnogenol® and Centella Asiatica for asymptomatic atherosclerosis progression
    G Belcaro
    Irvine3 Circulation Sciences, Department of Biomedical Sciences, G D Annunzio University, Pescara, Italy
    Int Angiol 33:20-6. 2014

Collaborators

Detail Information

Publications93

  1. ncbi request reprint [Treatment of severe intermittent claudication: ORACLE-PGE1 short term study. A randomised 40-week study. Evaluation of efficacy and costs]
    M R Cesarone
    Dipartimento di Scienze Biomediche, Vascular Lab, Universita di Chieti, Progetto Vascolare San Valentino Pe, ISVI Italian Society for Vascular Investigation, Italy
    Minerva Cardioangiol 50:683-90. 2002
    ..The efficacy and cost of prostaglandin E1 (PGE1) in severe intermittent claudication was studied comparing a long-term protocol (LTP) with a short-term protocol (STP) in a randomised 40-week study...
  2. ncbi request reprint Control of edema in hypertensive subjects treated with calcium antagonist (nifedipine) or angiotensin-converting enzyme inhibitors with Pycnogenol
    Gianni Belcaro
    Department of Biomedical Sciences, Irvine2 Vasc Lab, G D Annunzio University
    Clin Appl Thromb Hemost 12:440-4. 2006
    ..Pycnogenol controls this type of edema, it helps to prevent and limit long-term damage in the microcirculation in hypertensive patients, and allows the dose of anti-hypertensive drugs to be reduced in most patients...
  3. doi request reprint O-(beta-hydroxyethyl)-rutosides systemic and local treatment in chronic venous disease and microangiopathy: an independent prospective comparative study
    Gianni Belcaro
    Department of Biomedical Sciences, Chieti Pescara University, and the San Valentino Vascular Screening Project, Italy
    Angiology 59:7S-13S. 2008
    ..05). No adverse effects, tolerability problems, or compliance issues are noted. These results indicate an important role of HR in the treatment and control of CVI and venous microangiopathy...
  4. doi request reprint 5-Year control and treatment of edema and increased capillary filtration in venous hypertension and diabetic microangiopathy using O-(beta-hydroxyethyl)-rutosides: a prospective comparative clinical registry
    Gianni Belcaro
    Department of Biomedical Sciences, Chieti Pescara University, and the San Valentino Vascular Screening Project, Italy
    Angiology 59:14S-20S. 2008
    ..The prevention of ulcerations with HR is another important observation. The effects of HR seem to be partially dose related, and tolerability and compliance are good...
  5. ncbi request reprint Investigation of Pycnogenol® in combination with coenzymeQ10 in heart failure patients (NYHA II/III)
    G Belcaro
    Irvine3 Labs, Department Biomedical Sciences, Chieti Pescara University, Pescara, Italy
    Panminerva Med 52:21-5. 2010
    ..The aim of this single-blinded, 12-week observational study was to provide functional parameters such as exercise capacity, ejection fraction and distal edema...
  6. ncbi request reprint Improvement in signs and symptoms in psoriasis patients with Pycnogenol® supplementation
    G Belcaro
    Irvine 3 Circulation Vascular Labs, Department of Biomedical Sciences, CH PE University, Pescara, Italy
    Panminerva Med 56:41-8. 2014
    ..Further studies may indicate the possible systemic or local use of Pycnogenol and its role in controlling side effects and costs of standard management. ..
  7. ncbi request reprint Improved management of primary chronic fatigue syndrome with the supplement French oak wood extract (Robuvit®): a pilot, registry evaluation
    G Belcaro
    Irvine3 Circulation Vascular Labs and San Val Epidemiology Department of Biomedical Sciences, Chieti Pescara University, Pescara, Italy
    Panminerva Med 56:63-72. 2014
    ..Conclusion: This promising pilot supplement registry study indicates a new opportunity of management for these difficult and often neglected patients. Correlation between oxidative stress and CFS have to be better explored. ..
  8. ncbi request reprint Robuvit® (French oak wood extract) in the management of functional, temporary hepatic damage. A registry, pilot study
    G Belcaro
    Department of Biomedical Sciences, Irvine3 Labs, Chieti Pescara University, Spoltore, Pescara, Italy
    Minerva Med 105:41-50. 2014
    ..The activity of Robuvit® seems to be mediated by its anti-inflammatory activity. ..
  9. ncbi request reprint Pycnogenol® in postpartum symptomatic hemorrhoids
    G Belcaro
    Irvine3 Circulation Vascular Labs, Nicolaides Lab Department of Biomedical Sciences, Chieti Pescara University, Pescara, Italy
    Minerva Ginecol 66:77-84. 2014
    ..No significant side effects were observed. Conclusion: Pycnogenol appears to positively affect hemorrhoid signs and symptoms in the months after pregnancy. ..
  10. ncbi request reprint Pycnogenol® and Centella Asiatica for asymptomatic atherosclerosis progression
    G Belcaro
    Irvine3 Circulation Sciences, Department of Biomedical Sciences, G D Annunzio University, Pescara, Italy
    Int Angiol 33:20-6. 2014
    ....
  11. ncbi request reprint Evaluation of the effects of supplementation with Pycnogenol® on fitness in normal subjects with the Army Physical Fitness Test and in performances of athletes in the 100-minute triathlon
    G Vinciguerra
    Irvine 3 International Circulation Vascular Labs and San Val Epidemiology Department of Biomedical Sciences Chieti Pescara University, Pescara, Italy
    J Sports Med Phys Fitness 53:644-54. 2013
    ....
  12. ncbi request reprint Lady Prelox® improves sexual function in generally healthy women of reproductive age
    A Bottari
    Irvine 3 Circulation, Vascular Labs Department of Biomedical Sciences Chieti Pescara University, SS 16 bis 94 A, Spoltore, Pescara, Italy
    Minerva Ginecol 65:435-44. 2013
    ....
  13. ncbi request reprint A controlled study shows daily intake of 50 mg of French Pine Bark Extract (Pycnogenol®) lowers plasma reactive oxygen metabolites in healthy smokers
    G Belcaro
    Irvine 3 Circulation Vascular Labs, Chieti Pescara University, Spoltore, Pescara, Italy
    Minerva Med 104:439-46. 2013
    ..We investigated a low daily dosage of 50 mg of the antioxidant Pycnogenol for lowering oxidative stress in cigarette smokers who presented with good health...
  14. ncbi request reprint Product evaluation of Ureadin Rx Db (ISDIN) for prevention and treatment of mild-to-moderate xerosis of the foot in diabetic patients. Prevention of skin lesions due to microangiopathy
    G Ciammaichella
    Irvine3 Circulation Vascular Labs, Department of Biomedical Sciences, Chieti Pescara University, Pescara, Italy
    Panminerva Med 54:35-42. 2012
    ..Skin breaks, ulcerations, infection, investigator and patients' questionnaire, microcirculatory measurements, skin thickness (ultrasound), laser Doppler flux and other parameters were observed and evaluated at inclusion and 4 weeks...
  15. ncbi request reprint Meriva®, a lecithinized curcumin delivery system, in diabetic microangiopathy and retinopathy
    R Steigerwalt
    Dipartimento di Scienze Oftalmiche, Uniroma1, Rome, Italy
    Panminerva Med 54:11-6. 2012
    ..In the present study, the improvement of diabetic microangiopathy and retinopathy was evaluated in 38 diabetic patients treated with a novel curcumin phospholipids delivery form (Meriva®)...
  16. ncbi request reprint Thyroid cysts treatment with the sclerosing agent Atossiclerol. Long-term (5 to 15 years) follow-up
    G Belcaro
    Irvine3 Circulation Vascular Labs, Department of Biomedical Sciences, Chieti Pescara University, Pescara, Italy
    Panminerva Med 54:73-6. 2012
    ..The aim of this study was to evaluate the long-term efficacy of the sclerosing agent Atossisclerol in the treatment of benign, ecolucent, thyroid cysts...
  17. ncbi request reprint Meriva®, a lecithinized curcumin delivery system, in the control of benign prostatic hyperplasia: a pilot, product evaluation registry study
    A Ledda
    Irvine3 Circulation Vascular Labs, Department of Biomedical Sciences, Chieti Pescara University, Pescara, Italy
    Panminerva Med 54:17-22. 2012
    ..No other drugs or food supplement were used during the study...
  18. ncbi request reprint Deep vein thrombosis and pulmonary embolism in a patient affected by uterine fibroids: clinical case
    E Ippolito
    Department of Biomedical Surgery and Odontological Sciences, University of Milan, Milan, Italy
    Panminerva Med 54:97-9. 2012
    ..The patients was sent home in good clinical conditions, with anticoagulant therapy; later the uterine fibroma was treated with hysterectomy...
  19. ncbi request reprint Venous and diabetic ulcerations: management with topical multivalent silver oxide ointment
    G Belcaro
    Irvine3 Labs, Department of Biomedical Sciences, Chieti Pescara University, Pescara, Italy
    Panminerva Med 52:37-42. 2010
    ..The goal of this pilot registry study is to evaluate the efficacy and safety of a uniquely designed ointment containing multivalent silver oxide (Ag4O4) in the healing of difficult diabetic or venous ulcerations...
  20. ncbi request reprint MF Afragil® in the treatment of 34 menopause symptoms: a pilot study
    G Belcaro
    Irvine3 Labs, Department of Biomedical Sciences, Chieti Pescara University, Pescara, Italy
    Panminerva Med 52:49-54. 2010
    ..A combination of calcium, vitamin D3, lycopene , astaxantin and Citrus bioflavoid (MF Afragil®) was administered for a period of 8 weeks to 65 women to determine its effects in reducing signs/symptoms of climacteric status...
  21. ncbi request reprint Pycnogenol may alleviate adverse effects in oncologic treatment
    G Belcaro
    Vascular Labs and Physiology, Department of Biomedical Sciences, Gabriele d Annunzio University, Chieti Pescara, Chieti, Italy
    Panminerva Med 50:227-34. 2008
    ..The aim of this study was to explore in a pilot trial whether supplementation with French maritime pine bark extract Pycnogenol could alleviate side effects and improve patient's quality of life...
  22. doi request reprint Lymphatic tissue transplant in lymphedema--a minimally invasive, outpatient, surgical method: a 10-year follow-up pilot study
    Gianni Belcaro
    Irvine2 Vascular Lab, Department of Biomedical Sciences, Chieti Pescara University, San Valentino, Italy
    Angiology 59:77-83. 2008
    ..Thus, this early report proposes a new, minimally invasive method to improve lymphedema. Studies in progress will indicate the role of lymphatic transplant in the management of lymphedema and the best indications for this method...
  23. ncbi request reprint Cramps and muscular pain: prevention with pycnogenol in normal subjects, venous patients, athletes, claudicants and in diabetic microangiopathy
    G Vinciguerra
    Irvine 2 Vascular Laboratory and Physiology Department of Biomedical Sciences, G D Annunzio University, Chieti, Italy
    Angiology 57:331-9. 2006
    ....
  24. ncbi request reprint Improvement of microcirculation and healing of venous hypertension and ulcers with Crystacide: evaluation with a microcirculatory model, including free radicals, laser doppler flux, and PO2/PCO2 measurements
    Gianni Belcaro
    Irvine Vascular Laboratory and Physiology, Department of Biomedical Sciences, Chieti University, San Valentino Vascular Screening Project, PE, Italy
    Angiology 58:323-8. 2007
    ..In conclusion, in chronic venous insufficiency and venous ulcerations, local treatment with Crystacide (10 days) improves the microcirculation and decreases skin free radicals, thus improving healing...
  25. ncbi request reprint Superficial vein thrombosis (SVT), diffusion of thrombotic diseases, and increased global thrombogenicity: SVT as an important spy disease indicating environmental contamination by estrogens. Introduction
    Gianni Belcaro
    Department of Biomedical Science, G D Annunzio University, Pescara, Italy
    Angiology 58:5S-6S. 2007
  26. ncbi request reprint Prevention of flu episodes with colostrum and Bifivir compared with vaccination: an epidemiological, registry study
    G Belcaro
    Department of Biomedical Sciences, Irvine3 Circulation Vascular Labs and San Valentino Vascular Screening Project, G D Annunzio University, Chieti, Pescara, Italy
    Panminerva Med 52:269-75. 2010
    ..Compliance was very good. In conclusion, the administration of immunomodulators is very cost effective and appears to be more effective than vaccination to prevent flu...
  27. ncbi request reprint Topical formulation of heparin is effective in reducing the symptoms of superficial venous thrombosis: a monocenter, observer-blind, placebo-controlled randomized study
    G Belcaro
    Irvine3 Labs, Department of Biomedical Sciences, Chieti Pescara University, Pescara, Italy
    Panminerva Med 53:3-11. 2011
    ..400 IU/g heparin spraygel) in patients with superficial vein thrombosis (SVT) of the lower limbs...
  28. ncbi request reprint Silver oxide ointment wound dressing in venous ulcerations: home, self-management
    G Belcaro
    Irvine3 Labs, Department of Biomedical Sciences Chieti Pescara University, Pescara, Italy
    Panminerva Med 53:29-33. 2011
    ..This pilot product evaluation registry study has evaluated the efficacy and safety of an antimicrobial silver oxide wound dressing ointment ("Silver Oxide Ointment") as part of the treatment of 'difficult' venous ulcerations...
  29. ncbi request reprint Vascular screening in andropause: non-invasive investigations in vascular disease screening
    G Belcaro
    Irvine Laboratory, St Mary s Hospital at Imperial College, London
    Curr Med Res Opin 16:s68-71. 2000
    ..Penile fibrosis contributes to the pathogenesis of ED. Whether this change is associated with hypertension needs to be established by further studies...
  30. ncbi request reprint Microcirculatory studies in erectile disorders
    G Belcaro
    Irvine Laboratory, St Mary s Hospital at Imperial College, London
    Curr Med Res Opin 16:s72-5. 2000
    ..g. after intracavernosal PGE1). These techniques remain non-diagnostic in individual patients. However, in groups of patients they may produce useful information (e.g. to assess treatments for ED)...
  31. ncbi request reprint Potential role of curcumin phytosome (Meriva) in controlling the evolution of diabetic microangiopathy. A pilot study
    G Appendino
    Department of Chemical, Food, Pharmaceutical and Pharmacological Sciences, University of Piemonte Orientale, Novara, Italy
    Panminerva Med 53:43-9. 2011
    ..The aim of the present study was to evaluate the improvement of diabetic microangiopathy in patients suffering from this condition since at least five years, and whose disease was managed without insulin...
  32. ncbi request reprint TECA (Titrated Extract of Centella Asiatica): new microcirculatory, biomolecular, and vascular application in preventive and clinical medicine. A status paper
    G Belcaro
    Irvine3 Labs, Department of Biomedical Sciences Chieti Pescara University, Pescara, Italy
    Panminerva Med 53:105-18. 2011
    ....
  33. ncbi request reprint Improvement in cochlear flow in patients with tinnitus with the complex supplement Acustop: a product evaluation
    M G Grossi
    Irvine3 Labs, Department of Biomedical Sciences Chieti Pescara University, Pescara, Italy
    Panminerva Med 53:89-93. 2011
    ..The aim was to improve cochlear flow decreasing the level of tinnitus...
  34. ncbi request reprint Pycnogenol® supplementation improves cognitive function, attention and mental performance in students
    R Luzzi
    Irvine3 Labs, Department of Biomedical Sciences Chieti Pescara University, Pescara, Italy
    Panminerva Med 53:75-82. 2011
    ..Pycnogenol® was used in healthy students; the supplement was used with the aim of enhancing "normal" mental performances...
  35. ncbi request reprint Supplementation with Pycnogenol® improves signs and symptoms of menopausal transition
    S Errichi
    Irvine3 Labs, Department of Biomedical Sciences Chieti Pescara University, Pescara, Italy
    Panminerva Med 53:65-70. 2011
    ..The aim of this study was to evaluate the efficacy of Pycnogenol® standardized pine bark extract for alleviation of signs and symptoms associated with menopausal transition...
  36. ncbi request reprint Pycnogenol® improvements in asthma management
    G Belcaro
    Irvine3 Labs, Department of Biomedical Sciences Chieti Pescara University, Pescara, Italy
    Panminerva Med 53:57-64. 2011
    ..Pycnogenol® anti-inflammatory activities may be supportive when taken in addition to inhalation corticosteroid (ICS), putatively allowing for a reduction in dosage and frequency of ICS administration...
  37. ncbi request reprint Aescin: microcirculatory activity. Effects of accessory components on clinical and microcirculatory efficacy
    R Luzzi
    Irvine3 Labs, Department of Biomedical Sciences, Chieti Pescara University, Pescara, Italy
    Panminerva Med 53:51-5. 2011
    ..They do not have - at the dosage used - a specific or independent action. An open, registry study of patients - a group with chronic venous insufficiency (CVI) and a group of patients with diabetic microangiopathy were completed...
  38. ncbi request reprint Gore external valve support for superficial saphenous vein incompetence: a 10-year, follow-up registry
    G Belcaro
    Irvine3 Labs, Department of Biomedical Sciences, Chieti Pescara University, Pescara, Italy
    Panminerva Med 53:35-41. 2011
    ....
  39. ncbi request reprint HR, 0-(beta-hydroxyethyl)-rutosides, in comparison with diosmin+hesperidin in chronic venous insufficiency and venous microangiopathy: an independent, prospective, comparative registry study
    M R Cesarone
    Irvine2 Vasc Lab and Physiology, Department of Biomedical Sciences, Chieti University, San Valentino Vascular Screening Project, Italy
    Angiology 56:1-8. 2005
    ..The comparison with D+H indicates that HR is comparatively more effective both on microcirculatory parameters and on signs/symptoms of CVI...
  40. doi request reprint Improvement of signs and symptoms of chronic venous insufficiency and microangiopathy with Pycnogenol: a prospective, controlled study
    M R Cesarone
    Department of Biomedical Sciences, G D Annunzio, Chieti Pescara University, Faculty of Motory Sciences, L Aquila University, Italy
    Phytomedicine 17:835-9. 2010
    ..05). No side-effects were observed; compliance and tolerability were very good. This study corroborates a significant clinical role for Pycnogenol in the management, treatment and control of CVI also in combination with compression...
  41. ncbi request reprint Prevention of edema and flight microangiopathy with Venoruton (HR), (0-[beta-hydroxyethyl]-rutosides) in patients with varicose veins
    M R Cesarone
    Vascular Laboratory and San Valentino Vascular Screening Project, Department of Biomedical Sciences, G D Annunzio University, Chieti Pescara and Faculty of Motor Sciences, Italy
    Angiology 56:289-93. 2005
    ..The higher level of flux and VAR and the reduction in edema indicate a positive effect of HR on the microcirculation. This study confirms that HR prophylaxis is effective to control flight microangiopathy associated with edema...
  42. ncbi request reprint Rapid relief of signs/symptoms in chronic venous microangiopathy with pycnogenol: a prospective, controlled study
    M R Cesarone
    Irvine2 Vascular Lab and Physiology, Department of Biomedical Sciences, G Annunzio, Chieti Pescara University, San Valentino Vascular Screening Project, Faculty of Motory Sciences, L Aquila University, Italy
    Angiology 57:569-76. 2006
    ..The treatment may be also useful to prevent ulcerations by controlling the level of venous microangiopathy...
  43. ncbi request reprint Venoruton vs Daflon: evaluation of effects on quality of life in chronic venous insufficiency
    M R Cesarone
    Irvine2 Vascular Laboratory and Physiology, Department of Biomedical Sciences, Chieti University, San Valentino Vascular Screening Project, Italy
    Angiology 57:131-8. 2006
    ..The comparison with D+H indicates that oxerutins is comparatively more effective on Ve-QOL and on signs/symptoms of CVI...
  44. ncbi request reprint Prevention of venous thrombosis in long-haul flights with Flite Tabs: the LONFLIT-FLITE randomized, controlled trial
    M R Cesarone
    Department of Biomedical Sciences, Irvine2 Vascular Lab, G D Annunzio University, San Valentino Vascular Screening Project Pe, Pescara, Italy
    Angiology 54:531-9. 2003
    ..4%) in the treatment group (p < 0.05). Events were asymptomatic. In conclusion, Flite Tabs were effective in reducing thrombotic events and in controlling edema in high-risk subjects in long flights...
  45. ncbi request reprint Improvement of microcirculation and healing of venous hypertension and ulcers with Crystacide. Evaluation of free radicals, laser Doppler flux and PO2. A prospective-randomized-controlled study
    G Belcaro
    Irvine2 Vascular Laboratory and Physiology, Department of Biomedical Sciences, Chieti University, San Valentino Vascular Screening Project, Italy
    Angiology 54:325-30. 2003
    ..05). In conclusion, in venous ulcerations, local treatment with Crystacide (10 days) improves the microcirculation and decreases skin free radicals improving healing...
  46. ncbi request reprint HR, 0-(beta-hydroxyethyl)-rutosides; (Venoruton): rapid relief of signs/symptoms in chronic venous insufficiency and microangiopathy: a prospective, controlled study
    M R Cesarone
    Irvine2 Vascular Lab and Physiology, Department of Biomedical Sciences, G D Annunzio, Chieti Pescara University, San Valentino Vascular Screening Project, San Valentino, Italy
    Angiology 56:165-72. 2005
    ..Venous microangiopathy and edema were improved by the treatment with HR within a few days. The effects were visible with both dosages, in both severity groups...
  47. ncbi request reprint PGE(1) treatment of severe intermittent claudication (short-term versus long-term, associated with exercise)--efficacy and costs in a 20-week, randomized trial
    G Belcaro
    San Valentino PAP PEA Project, Pescara, Italy
    Angiology 51:S15-26. 2000
    ..With STP less time is spent in infusion and more in the exercise program. STP reduces costs, speeds rehabilitation, and may be easily used in a larger number of nonspecialized units...
  48. ncbi request reprint Prevention of edema in long flights with Pycnogenol
    M R Cesarone
    Department of Biomedical Sciences, Irvine2 Vascular Lab, G D Annunzio University and San Valentino Vascular Screening Project Pe, Faculty of Motory Sciences, L Aquila University, Italy
    Clin Appl Thromb Hemost 11:289-94. 2005
    ..05). These results indicate a positive effect of Pycnogenol on edema during long flights when considering subjective and objective data. No unwanted effects were observed...
  49. ncbi request reprint Treatment of ankle sprain in patients with vascular diseases of the lower limbs
    M R Cesarone
    Irvine3 Vascular Laboratory and Physiology, Department of Biomedical Sciences, Pescara, Italy
    Minerva Cardioangiol 56:39-46. 2008
    ..The observed clinical outcomes of the patients included in this small, pilot study indicated that locally applied ketoprofen 10% spray gel is effective in relieving the pain and other symptoms of ankle sprain in vascular patients...
  50. ncbi request reprint Venoruton®: post thrombotic syndrome. Clinical improvement in venous insufficiency (signs and symptoms) with Venoruton®. A five-year, open-registry, efficacy study
    E Ippolito
    Irvine3 Labs, Department of Biomedical Sciences Chieti Pescara University, Pescara, Italy
    Panminerva Med 53:13-9. 2011
    ..The study evaluated: 1) variations in peripheral edema with an analogue scoring system; 2) ankle circumference at the PTS limb in comparison with the normal contralateral limb...
  51. ncbi request reprint Prevention of post thrombotic syndrome with Pycnogenol® in a twelve month study
    B M Errichi
    Irvine3 Labs, Department of Biomedical Sciences Chieti Pescara University, Pescara, Italy
    Panminerva Med 53:21-7. 2011
    ....
  52. ncbi request reprint Flight microangiopathy on long-haul flights: prevention of edema and microcirculation alterations with Venoruton
    M R Cesarone
    Irvine2 Vascular Laboratory, Department of Biomedical Sciences, Chieti University, Italy
    Clin Appl Thromb Hemost 9:109-14. 2003
    ..In conclusion, HR is useful for reducing the increased capillary filtration and in controlling edema in patients with chronic venous disease in long-haul flights. HR is effective to control flight microangiopathy associated with edema...
  53. ncbi request reprint Improvement of diabetic microangiopathy with pycnogenol: A prospective, controlled study
    M R Cesarone
    Irvine2 Vascular Lab and Physiology, Department of Biomedical Sciences, G D Annunzio, Chieti Pescara University, San Valentino Vascular Screening Project, Faculty of Motory Sciences, L Aquila University, Italy
    Angiology 57:431-6. 2006
    ..The study indicates the clinical role of Pycnogenol in the management, treatment, and control of this common clinical problem. The treatment may be also useful to prevent diabetic ulcerations by controlling the level of microangiopathy...
  54. ncbi request reprint Venous ulcers: microcirculatory improvement and faster healing with local use of Pycnogenol
    G Belcaro
    Department of Biomedical Sciences, Chieti Pescara University, Italy
    Angiology 56:699-705. 2005
    ..According to this pilot study Pycnogenol appears to have an important role in local treatment of venous ulcers improving healing and signs/symptoms...
  55. ncbi request reprint Comparison of Pycnogenol and Daflon in treating chronic venous insufficiency: a prospective, controlled study
    M R Cesarone
    Irvine2 Vascular Lab and Physiology, Department of Biomedical Sciences, G D Annunzio, Chieti Pescara University, San Valentino Vascular Screening Project, Faculty of Motory Sciences, L Aquila University, Italy
    Clin Appl Thromb Hemost 12:205-12. 2006
    ....
  56. ncbi request reprint LINFAVENIX: improvement of signs and symptoms of chronic venous insufficiency and microangiopathy
    M R Cesarone
    Irvine3 Vasc Lab and Physiology, Dept of Biomedical Sciences, Chieti Pescara University, Chieti Pescara, Italy
    Minerva Cardioangiol 56:55-61. 2008
    ..In conclusion venous microangiopathy and edema were improved by the treatment with Linfavenix (better in comparison with compression) in a few days...
  57. ncbi request reprint Variations in plasma free radicals with topical aescin + essential phospholipids gel in venous hypertension: new clinical data
    A Ricci
    Irvine2 Vascular Laboratory, Department of Biomedical Sciences, G D Annunzio University, Italy
    Angiology 55:S11-4. 2004
    ..The evaluation of PFR is an important new physiologic parameter that can be associated with other noninvasive tests to study the microcirculation and its evolution and improvement with systemic or topical medical treatment...
  58. ncbi request reprint Evaluation of the local effects of vitamin E (E-Mousse) on free radicals in diabetic microangiopathy: a randomized, controlled trial
    I Ruffini
    Irvine Vascular Laboratory and Physiology, London, UK
    Angiology 54:415-21. 2003
    ..02). Their tolerability was good. In conclusion local treatment with E-mousse for 3 weeks in diabetic microangiopathy improves skin microcirculation and the metabolic condition as shown by the decrease in FR...
  59. ncbi request reprint Lady Prelox® improves sexual function in post-menopausal women
    A Bottari
    Irvine3 Circulation Vascular Labs, Department of Biomedical Sciences, Chieti Pescara University, Pescara, Italy
    Panminerva Med 54:3-9. 2012
    ..The aim of this pilot, single-blinded study was to evaluate the efficacy of a proprietary, dietary supplement Lady Prelox® for supporting and improving sexual function in generally healthy, post-menopausal women...
  60. ncbi request reprint Osteoporosis of the jaw. Product evaluation: mf Odontovis Calcium®
    R Luzzi
    Irvine3 Labs, Department of Biomedical Sciences Chieti Pescara University, Pescara, Italy
    Panminerva Med 53:83-7. 2011
    ..The upper jaw density was tested with an ultrasound method, evaluating the grey scale median of the images (GSM)...
  61. ncbi request reprint A plaster combining diclofenac and heparin: microcirculatory evaluation in 2 models of high-perfusion microangiopathy
    G Belcaro
    Department of Biomedical Sciences, Chieti Pescara University, Italy
    Angiology 56:707-13. 2005
    ..It should be interesting to investigate the product in comparable clinical conditions in which it may be useful to act pharmacologically both on inflammation and microcirculatory disturbances that delay the recovery of patients...
  62. ncbi request reprint [Severe intermittent claudication: PGE1 treatment. A 40-week registry, efficacy and costs]
    R Luzzi
    Department of Biomedical Sciences, Chieti Pescara University, Italy
    Minerva Cardioangiol 60:405-13. 2012
    ..Treatment with PGE1 has been successfully used to manage IC patients. This registry has evaluated safety and costs of PGE1 in the management of IC...
  63. ncbi request reprint Four-week treatment with Essaven gel in diabetic microangiopathy--a placebo-controlled, randomized study
    M T De Sanctis
    Irvine2 Vascular Laboratory, Department of Biomedical Sciences, Chieti University and San Valentino Vascular Screening Project, Italy
    Angiology 52:S49-55. 2001
    ..In conclusion local treatment for 4 weeks with standardized application of EG improves the microcirculation in subjects with DM. The changes are detectable even 1 week after the end of the treatment period...
  64. ncbi request reprint Nomograms used to define the short-term treatment with PGE(1) in patients with intermittent claudication and critical ischemia. The ORACL.E (Occlusion Revascularization in the Atherosclerotic Critical Limb) Study Group. The European Study
    G Belcaro
    San Valentino PAP PEA Project, Pescara, Italy
    Angiology 51:S3-13; discussion S14. 2000
    ..The data are being collected in the ORACL.E database and will be analyzed within 12 months after the publication of this report...
  65. ncbi request reprint Clinical improvement in chronic venous insufficiency signs and symptoms with Venoruton® (HR): an 8-month, open-registry, cost-efficacy study
    M R Cesarone
    Irvine3 Labs, Department of Biomedical Sciences, Chieti Pescara Univeristy, Pescara, Italy
    Panminerva Med 52:43-8. 2010
    ..This study evaluated the clinical efficacy of Venoruton (O-(beta-hydroxyethyl)-rutosides) (HR) (Novartis Consumer Healthcare) in subjects with severe chronic venous insufficiency (CVI)...
  66. ncbi request reprint Prevention of venous thrombosis and thrombophlebitis in long-haul flights with pycnogenol
    G Belcaro
    Department of Biomedical Sciences, Irvine2 Vascular Lab, G D Annunzio University and San Valentino Vascular Screening Project Pe, Faculty of Motory Sciences, L Aquila University, Italy
    Clin Appl Thromb Hemost 10:373-7. 2004
    ..025). No unwanted effects were observed. In conclusion, this study indicates that Pycnogenol treatment was effective in decreasing the number of thrombotic events (DVT and SVT) in moderate-to-high risk subjects, during long-haul flights...
  67. ncbi request reprint Efficacy of topical treatment with aescin + essential phospholipids gel on capillary fragility
    M R Cesarone
    Irvine2 Vascular Laboratory, Department of Biomedical Sciences, G D Annunzio University, Italy
    Angiology 55:S23-5. 2004
    ..The tests were repeated in steps of two tests on different days. Between the two tests, with the VSC applied in different skin areas of the perimalleolar region, an interval of at least 30 minutes was observed...
  68. ncbi request reprint Treatment of superficial vein thrombosis: clinical evaluation of Essaven gel--a placebo-controlled, 8-week, randomized study
    L Incandela
    Irvine2 Vascular Laboratory, Department of Biomedical Sciences, Chieti University and San Valentino Vascular Screening Project, Italy
    Angiology 52:S69-72. 2001
    ..In conclusion local treatment with EG in SVT improves signs/symptoms much faster than placebo. This study confirms earlier observation on the effective, local use of EG in SVT...
  69. ncbi request reprint Prevention of recurrent deep venous thrombosis with sulodexide: the SanVal registry
    B M Errichi
    General Surgery Osp Guardiagrele Ch, University of Milan, Italy
    Angiology 55:243-9. 2004
    ..In this analysis the incidence of DVT in controls was 2.07 times higher than in the treatment group subjects. In conclusion sulodexide was effective in reducing recurrent thrombotic events in high-risk subjects...
  70. ncbi request reprint Two-week topical treatment with Essaven gel in patients with diabetic microangiopathy--a placebo-controlled, randomized study
    M R Cesarone
    Irvine2 Vascular Laboratory, Department of Biomedical Sciences, Chieti University and San Valentino Vascular Screening Project, Italy
    Angiology 52:S43-8. 2001
    ..In conclusion, local treatment for 2 weeks with standardized application of EG acutely improves the microcirculation in subjects with DM and small ulceration...
  71. ncbi request reprint Topical heparin: new observations
    M R Cesarone
    Irvine2 Vascular Lab and Physiology, Department of Biomedical Sciences, Chieti Pescara University, Faculty of Motory Sciences, L Aquila University, San Valentino, Italy
    Angiology 58:16S-20S. 2007
    ..Results from new studies and observations presented in this issue of Angiology could be a window for suggesting new significant clinical applications and therapeutic solutions...
  72. ncbi request reprint Diabetic ulcers: microcirculatory improvement and faster healing with pycnogenol
    G Belcaro
    Irvine2 Vasc Lab, Department of Biomedical Sciences, Chieti pescara University and San Valentino Vascular Screening Project, Westfalische Wilhelms Universitat Munster, Germany
    Clin Appl Thromb Hemost 12:318-23. 2006
    ..Combined local and systemic application of Pycnogenol may offer a new treatment of diabetic ulcers. Local treatment also speeds ulcer healing...
  73. ncbi request reprint Microcirculatory efficacy of topical treatment with aescin + essential phospholipids gel on transcutaneous PO2 in venous insufficiency
    M R Cesarone
    Irvine2 Vascular Laboratory, Department of Biomedical Sciences, G D Annunzio University, Italy
    Angiology 55:S7-10. 2004
    ..Considering transcutaneous skin PO(2), treatment with AEPL in areas of venous microangiopathy is beneficial in the prevention of ulceration and improves skin healing...
  74. ncbi request reprint Induction and recovery phases of methacholine-induced bronchoconstriction using FEV1 according to the degree of bronchial hyperresponsiveness
    F Mannino
    Dipartimento di Scienze Cardiovascolari e Respiratorie, Sezione Malattie Respiratorie, , Rome, Italy
    Lung 179:137-45. 2001
    ....
  75. doi request reprint Treatment of osteoarthritis with Pycnogenol. The SVOS (San Valentino Osteo-arthrosis Study). Evaluation of signs, symptoms, physical performance and vascular aspects
    G Belcaro
    Irvine2 Vascular Laboratory, Department of Biomedical Sciences, Chieti pescara University and San Valentino Vascular Screening Project, San Valentino, PE, Italy
    Phytother Res 22:518-23. 2008
    ..After 3 months edema decreased in 79% of Pycnogenol patients (p < 0.05) vs 1% in controls. In conclusion, Pycnogenol offers an option for reduction of treatment costs and side effects by sparing antiinflammatory drugs...
  76. ncbi request reprint External femoral vein valvuloplasty with limited anterior plication (LAP): a 10-year randomized, follow-up study
    G Belcaro
    Irvine Laboratory, St Mary s Hospital at Imperial College, London, UK
    Angiology 50:531-6. 1999
    ..In conclusion, in selected subjects, with moderate deep venous incompetence, functional cusps, or incompetence mainly due to relative enlargement of the femoral vein, LAP may be an effective alternative to external valvuloplasty...
  77. ncbi request reprint Effects of shock waves on microcirculation, perfusion, and pain management in critical limb ischemia
    G Belcaro
    Irvine2 Vascular Laboratory, Department of Biomedical Sciences, Chieti Pescara University, San Valentino Vascular Screening Center, San Valentino, Italy
    Angiology 56:403-7. 2005
    ..These results are very interesting, confirming previous observations, and opening new treatment options in CLI. The skin flow improvement did not relate to an increase in pressure...
  78. ncbi request reprint Faster healing of venous ulcers with crystacide: a clinical and microcirculatory 8-week registry study
    M R Cesarone
    Irvine3 Labs, Department Biomedical Sciences, Chieti Pescara University, Pescara, Italy
    Panminerva Med 52:11-4. 2010
    ..After briefing, one group used Crystacide and standard management for ulcers, including compression. A comparable group that did not use Crystacide was also evaluated...
  79. ncbi request reprint Expanded polytetrafluoroethylene in external valvuloplasty for superficial or deep vein incompetence
    G Belcaro
    Cardiovascular Institute, Chieti University, Pescara, Italy
    Angiology 51:S27-32. 2000
    ..Therefore, in this observational study, ePTFE implants used to treat or correct venous incompetence were well tolerated on a long-term basis...
  80. ncbi request reprint Prevention of venous thrombosis with elastic stockings during long-haul flights: the LONFLIT 5 JAP study
    G Belcaro
    Department of Biomedical Sciences, Irvine2 Vascular Lab, G D Annunzio University, San Valentino Vascular Screening Project, PE, Italy
    Clin Appl Thromb Hemost 9:197-201. 2003
    ..All events were asymptomatic. Considering these observations, Scholl Flight Socks are effective in reducing the incidence of DVT in high-risk subjects...
  81. ncbi request reprint Antilip®: treatment of subjects with high total cholesterol tolerability and efficacy in a short-term registry study
    M R Cesarone
    Irvine3 Labs, Department Biomedical Sciences, Chieti Pescara University, Pescara, Italy
    Panminerva Med 52:15-9. 2010
    ..The aim of the paper was to describe a new formula (Antilip®) consisting of very low dosages of polyglucosamine, phytosterols and Monascus purpureus. It was given to subjects affected by high cholesterol levels...
  82. ncbi request reprint Management of superficial vein thrombosis and thrombophlebitis: status and expert opinion document
    M R Cesarone
    Vascular Lab, Department of Biomedical Science, G D Annunzio University, Pescara San Valentino Vascular Screening Project, Italy
    Angiology 58:7S-14S; discussion 14S-15S. 2007
    ..Prevention of superficial vein thrombosis should be considered on the basis of patient's history and clinical evaluation...
  83. ncbi request reprint Endovascular sclerotherapy, surgery, and surgery plus sclerotherapy in superficial venous incompetence: a randomized, 10-year follow-up trial--final results
    G Belcaro
    PAP PEA Institute, San Valentino, Pescara, Italy
    Angiology 51:529-34. 2000
    ..2 cm after ES). The cost of ES was 68% of surgery while the cost of surgery and sclerotherapy was 122% of surgery only. Endovascular sclerotherapy is an effective, cheaper treatment option, but surgery after 10 years is superior...
  84. ncbi request reprint HR (Venoruton1000, Paroven, 0-[beta-hydroxyethyl]-rutosides) vs. Daflon 500 in chronic venous disease and microangiopathy: an independent prospective, controlled, randomized trial
    G Belcaro
    Irvine2 Vascular Laboratory and Physiology, Department of Biomedical Sciences, Chieti University, San Valentino Vascular Screening Project, Italy
    J Cardiovasc Pharmacol Ther 7:139-45. 2002
    ....
  85. ncbi request reprint The LONFLIT4--Concorde Deep Venous Thrombosis and Edema Study: prevention with travel stockings
    Maria Rosaria Cesarone
    A San Valentino Vascular Screening Project, Department of Biomedical Sciences, Irvine2 Vascular Laboratory, G D Annunzio University, Chieti, Italy
    Angiology 54:143-54. 2003
    ..Stockings are effective in controlling edema during flights even in subjects with microangiopathy and edema. Compression was well tolerated in normal subjects and in patients...
  86. ncbi request reprint Microcirculatory effects of Viatromb spray gel heparin in chronic venous insufficiency: evaluation of TcPO2 and PCO2--a product evaluation study
    Maria Rosaria Cesarone
    Irvine2 Vascular Lab and Physiology, Department of Biomedical Sciences, G D Annunzio, Chieti Pescara University
    Angiology 58:21S-26S. 2007
    ..There was a good effect for compression only. These differences are significant, as they can be observed even in small groups (10-15 patients). No treatment side effects were observed, and compliance and tolerability were very good...
  87. ncbi request reprint Foam-sclerotherapy, surgery, sclerotherapy, and combined treatment for varicose veins: a 10-year, prospective, randomized, controlled, trial (VEDICO trial)
    G Belcaro
    Irvine 2 Vascular Laboratory, Department Biomedical Sciences, and San Valentino Vascular Screening Project, Chieti University, Pescara, Italy
    Angiology 54:307-15. 2003
    ..Standard," low-dose sclerotherapy appears to be less effective than high-dose sclero and foam-sclerotherapy which may obtain, in selected subjects, results comparable to surgery...
  88. ncbi request reprint The LONFLIT4-VENORUTON study: a randomized trial prophylaxis of flight-edema in normal subjects
    Gianni Belcaro
    Department of Biomedical Sciences, Irvine2 Vascular Lab, Chieti University, Italy
    Clin Appl Thromb Hemost 9:19-23. 2003
    ..The combined evaluation of the edema score is significantly favorable for subjects under prophylaxis with Venoruton...
  89. ncbi request reprint The LONFLIT4-Concorde--Sigvaris Traveno Stockings in Long Flights (EcoTraS) Study: a randomized trial
    Maria Rosaria Cesarone
    Department of Biomedical Sciences, Irvine Vascular Laboratory, Chieti University, San Valentino Vascular Screening Project Pe, Italy
    Angiology 54:1-9. 2003
    ..The tolerability of the stockings was very good and there were no complaints or side effects. In conclusion Sigvaris Traveno stockings are very effective in controlling edema in long-haul flights...
  90. doi request reprint Pycnogenol improves microcirculation, retinal edema, and visual acuity in early diabetic retinopathy
    Robert Steigerwalt
    Irvine2 Vascular Labs and Microcirculation, Physiology, Department of Biomedical Sciences, G D Annunzio University, General Surgery, Guardiagrele Ch Ortona Pe Pescara, San Valentino Vascular Screening Project, San Valentino, Italy
    J Ocul Pharmacol Ther 25:537-40. 2009
    ..The aim of our study was to show protective effects of Pycnogenol in early stages of retinopathy, characterized by mild to moderate retinal edema in the absence of hemorrhages or hard exudates in the macula center...
  91. ncbi request reprint The LONFLIT4-Venoruton Study: a randomized trial--prophylaxis of flight-edema in venous patients
    Maria Rosaria Cesarone
    Department of Biomedical Sciences, Irvine2 Vascular Laboratory, Chieti University, and San Valentino Vascular Screening Project, PE, Italy
    Angiology 54:137-42. 2003
    ..The combined evaluation of the edema score is significantly favorable for patients treated with Venoruton. No deep vein thrombosis or superficial vein thrombosis was observed in this study...
  92. ncbi request reprint Circulating endothelial cells in venous blood as a marker of endothelial damage in chronic venous insufficiency: improvement with venoruton
    Maria Rosaria Cesarone
    Irvine2 Vascular Lab and Physiology, Department of Biomedical Sciences, G D Annunzio, University, Chieti Pescara, Italy
    J Cardiovasc Pharmacol Ther 11:93-8. 2006
    ..This suggests an important role of this compound in protecting the endothelium and offers new potentially important therapeutic options that are not limited only to venous disease...
  93. doi request reprint Pycnogenol treatment of acute hemorrhoidal episodes
    Gianni Belcaro
    Irvine2 Vascular Labs and Microcirculation, Physiology, Department of Biomedical Sciences, G D Annunzio University, General Surgery, Guardiagrele Ch Ortona Pe Pescara, San Valentino Vascular Screening Project, Italy
    Phytother Res 24:438-44. 2010
    ..The application of Pycnogenol eases the management of acute hemorrhoidal attacks and help avoid bleedings...