M Zappa

Summary

Affiliation: Centro per lo Studio e la Prevenzione Oncologica
Country: Italy

Publications

  1. ncbi Practice of opportunistic PSA screening in the Florence District
    M Zappa
    Descriptive and Epidemiological Unit, Center for Study and Prevention of Cancer CSPO, Via di San Salvi, 12, 50135, Florence, Italy
    Eur J Cancer Prev 12:201-4. 2003
  2. ncbi Mammography screening in elderly women: efficacy and cost-effectiveness
    Marco Zappa
    Descriptive and Epidemiological Unit, Center for Study and Prevention of Cancer CSPO, Scientific Institute of Tuscany Region, Via di San Salvi, 12, 50135, Florence, Italy
    Crit Rev Oncol Hematol 46:235-9. 2003
  3. pmc Lower protection of cytological screening for adenocarcinomas and shorter protection for younger women: the results of a case-control study in Florence
    M Zappa
    Clinical and Descriptive Epidemiological Unit, CSPO Centro per lo Studio e la Prevenzione Oncologica, Via di San Salvi 12, Florence 50135, Italy
    Br J Cancer 90:1784-6. 2004
  4. ncbi Gastric cancer after positive screening faecal occult blood testing and negative assessment
    M Zappa
    Center for Study and Prevention of Cancer CSPO, Via di San Salvi, 12, 50135 Florence, Italy
    Dig Liver Dis 39:321-6. 2007
  5. ncbi [Evaluation of the impact of HPV vaccination]
    Marco Zappa
    UO Valutazione screening, Dipartimento di Epidemiologia, CSPO Firenze Istituto scientifico della Regione Toscana
    Epidemiol Prev 31:81-5. 2007
  6. ncbi Measuring interval cancers in population-based screening using different assays of fecal occult blood testing: the District of Florence experience
    M Zappa
    Center for the Study and Prevention of Cancer CSPO A O Careggi, Florence, Italy
    Int J Cancer 92:151-4. 2001
  7. pmc Immunochemical faecal occult blood test: number of samples and positivity cutoff. What is the best strategy for colorectal cancer screening?
    G Grazzini
    Department of Screening, ISPO Cancer Prevention and Research Institute Florence, Viale Volta 171, Florence, Italy
    Br J Cancer 100:259-65. 2009
  8. ncbi Predicting prostate biopsy outcome by findings at digital rectal examination, transrectal ultrasonography, PSA, PSA density and free-to-total PSA ratio in a population-based screening setting
    S Ciatto
    Centro per lo Studio e la Prevenzione Oncologica, Florence, Italy
    Int J Biol Markers 16:179-82. 2001
  9. ncbi A feasibility study of screening for endometrial carcinoma in postmenopausal women by ultrasonography
    S Ciatto
    Centro per lo Studio e la Prevenzione Oncologica, Florence, Italy
    Tumori 81:334-7. 1995
  10. ncbi Effect of faecal occult blood testing on colorectal mortality: results of a population-based case-control study in the district of Florence, Italy
    M Zappa
    Centre for the Study and Prevention of Cancer CSPO, Florence, Italy
    Int J Cancer 73:208-10. 1997

Detail Information

Publications100

  1. ncbi Practice of opportunistic PSA screening in the Florence District
    M Zappa
    Descriptive and Epidemiological Unit, Center for Study and Prevention of Cancer CSPO, Via di San Salvi, 12, 50135, Florence, Italy
    Eur J Cancer Prev 12:201-4. 2003
    ..The aim of the present study was to evaluate the frequency of opportunistic screening by PSA in the District of Florence in the general population...
  2. ncbi Mammography screening in elderly women: efficacy and cost-effectiveness
    Marco Zappa
    Descriptive and Epidemiological Unit, Center for Study and Prevention of Cancer CSPO, Scientific Institute of Tuscany Region, Via di San Salvi, 12, 50135, Florence, Italy
    Crit Rev Oncol Hematol 46:235-9. 2003
    ..Over the age of 74 years, encouraging individualized decisions may be more appropriate and may indicate further screening for those subjects for whom the potential benefit outweighs the potential negative effects...
  3. pmc Lower protection of cytological screening for adenocarcinomas and shorter protection for younger women: the results of a case-control study in Florence
    M Zappa
    Clinical and Descriptive Epidemiological Unit, CSPO Centro per lo Studio e la Prevenzione Oncologica, Via di San Salvi 12, Florence 50135, Italy
    Br J Cancer 90:1784-6. 2004
    ..65 (95% confidence interval (CI) 0.26-1.64) and 0.15 (95% CI 0.07-0.31), for adenocarcinoma and squamous cancer, respectively. The duration of the protective effect was shorter in women below the age of 40 years than in older women...
  4. ncbi Gastric cancer after positive screening faecal occult blood testing and negative assessment
    M Zappa
    Center for Study and Prevention of Cancer CSPO, Via di San Salvi, 12, 50135 Florence, Italy
    Dig Liver Dis 39:321-6. 2007
    ..Gastric cancer may be suspected with otherwise unexplained positive faecal occult blood testing...
  5. ncbi [Evaluation of the impact of HPV vaccination]
    Marco Zappa
    UO Valutazione screening, Dipartimento di Epidemiologia, CSPO Firenze Istituto scientifico della Regione Toscana
    Epidemiol Prev 31:81-5. 2007
  6. ncbi Measuring interval cancers in population-based screening using different assays of fecal occult blood testing: the District of Florence experience
    M Zappa
    Center for the Study and Prevention of Cancer CSPO A O Careggi, Florence, Italy
    Int J Cancer 92:151-4. 2001
    ..The assumption that FOBT screening for CRC has to be based on a guaiac test should be reconsidered, and RPHA should be recommended as the standard FOBT for screening purposes...
  7. pmc Immunochemical faecal occult blood test: number of samples and positivity cutoff. What is the best strategy for colorectal cancer screening?
    G Grazzini
    Department of Screening, ISPO Cancer Prevention and Research Institute Florence, Viale Volta 171, Florence, Italy
    Br J Cancer 100:259-65. 2009
    ..Different strategies seem to have a greater impact on adenomas rather than on cancer detection rate. The study provides information when deciding screening protocols and to adapt them to local resources...
  8. ncbi Predicting prostate biopsy outcome by findings at digital rectal examination, transrectal ultrasonography, PSA, PSA density and free-to-total PSA ratio in a population-based screening setting
    S Ciatto
    Centro per lo Studio e la Prevenzione Oncologica, Florence, Italy
    Int J Biol Markers 16:179-82. 2001
    ..7-1.8). None of the possible variable combinations was clinically useful: the highest PPV (83.3%) was obtained with a combination of suspicious DRE/TRUS, PSAD >0.20 and F/T <0.15, which nevertheless missed 20 of 52 cancers...
  9. ncbi A feasibility study of screening for endometrial carcinoma in postmenopausal women by ultrasonography
    S Ciatto
    Centro per lo Studio e la Prevenzione Oncologica, Florence, Italy
    Tumori 81:334-7. 1995
    ..Studies of screening for other carcinomas may be considered of higher priority...
  10. ncbi Effect of faecal occult blood testing on colorectal mortality: results of a population-based case-control study in the district of Florence, Italy
    M Zappa
    Centre for the Study and Prevention of Cancer CSPO, Florence, Italy
    Int J Cancer 73:208-10. 1997
    ..54; 95% CI, 0.3-0.9) and increased towards unity subsequently. Our results suggest that screening for CRC by biennial faecal occult blood testing can reduce mortality from the disease...
  11. ncbi Screening for colorectal cancer by faecal occult blood test: comparison of immunochemical tests
    G Castiglione
    Presidio per la Prevenzione Oncologica, Azienda Ospedaliera Careggi, Florence, Italy
    J Med Screen 7:35-7. 2000
    ..To compare two immunochemical faecal occult blood tests based on reversed passive haemagglutination (RPHA) or latex agglutination (Hdia) in a population based screening setting...
  12. pmc Quantification of the effect of mammographic screening on fatal breast cancers: The Florence Programme 1990-96
    E Paci
    Unit of Epidemiology, CSPO, Florence, Italy
    Br J Cancer 87:65-9. 2002
    ..58, 95% CI : 0.45-0.74). This study confirmed that new treatments and the first rounds of the screening programme contributed to reducing mortality from breast cancer...
  13. ncbi Colorectal cancer screening by fecal occult blood testing: results of a population-based experience
    G Grazzini
    CSPO Presidio per la Prevenzione Oncologica, Azienda Ospedaliera Careggi, Florence, Italy
    Tumori 86:384-8. 2000
    ..The study evaluated the results of an experimental screening protocol for colorectal cancer by fecal occult blood testing in a municipality of the Province of Florence...
  14. ncbi Risk of endometrial cancer in breast cancer patients under long-term adjuvant treatment with tamoxifen
    S Cecchini
    Centro per lo Studio e la Prevenzione Oncologica, Florence, Italy
    Tumori 84:21-3. 1998
    ..Surveillance based on endometrial ultrasonography was poorly sensitive, but the favorable stage at diagnosis of screen-detected or interval endometrial cancers does not support a more aggressive screening approach...
  15. ncbi Predictors of random sextant biopsy outcome in screened men with PSA > 4 ng/mL and a negative sextant biopsy at previous screening. Experience in a population-based screening program in Florence
    S Ciatto
    Centro per lo Studio e la Prevenzione Oncologica, Florence, Italy
    Int J Biol Markers 19:89-92. 2004
    ..2%) of the benign biopsies while decreasing the sensitivity by 7.6% (1/13), and is thus suggested as a possible criterion for the indication of repeat random biopsy for persistent PSA elevation...
  16. ncbi Colposcopy as a primary screening test for cervical cancer
    S Cecchini
    Centro per lo Studio e la Prevenzione Oncologica, Florence, Italy
    Tumori 83:810-3. 1997
    ..At least in those settings where access to cytopathology may be difficult, screening by colposcopy should be considered as a possible alternative...
  17. ncbi Comparing two modalities of screening for prostate cancer: digital rectal examination + transrectal ultrasonography vs. prostate-specific antigen
    S Ciatto
    Centro per lo Studio e la Prevenzione Oncologica, Florence, Italy
    Tumori 81:225-9. 1995
    ..PSA seems the ideal test to be used in prospective controlled studies aimed at demonstrating screening efficacy...
  18. pmc Immunochemical vs guaiac faecal occult blood tests in a population-based screening programme for colorectal cancer
    G Castiglione
    Centro per lo Studio e la Prevenzione Oncologica, Florence, Italy
    Br J Cancer 74:141-4. 1996
    ..Further evaluation of Hemeselect cost-effectiveness and sensitivity is needed in order to assess the optimal threshold of positivity and screening frequency...
  19. ncbi Evaluation of diagnostic accuracy of screening by fecal occult blood testing (FOBT). Comparison of FOB Gold and OC Sensor assays in a consecutive prospective screening series
    T Rubeca
    Centro per lo Studio e la Prevenzione Oncologica, Florence, Italy
    Int J Biol Markers 21:157-61. 2006
    ....
  20. ncbi Detection of false-negative Pap smears using the PAPNET system
    G M Troni
    Department of Cytopathology, Center for Cancer Study and Prevention, Florence, Italy
    Tumori 86:455-7. 2000
    ..CONCLUSIONS: The present study provides further evidence that PAPNET-assisted screening may allow the detection of a few extra cases of CIN2+ lesions with respect to conventional reading, though at a very high cost...
  21. doi CT colonography before colonoscopy in subjects with positive faecal occult blood test. Preliminary experience
    L Sali
    Radiodiagnostic Section Department of Clinical Physiopathology, University of Florence, Viale G B Morgagni 85, Florence, Italy
    Radiol Med 115:1267-78. 2010
    ....
  22. ncbi Measurement of the cost of screening for cervical cancer in the district of Florence, Italy
    M Zappa
    Centre for the Study and Prevention of Cancer (CSPO, Florence, Italy
    Tumori 84:631-5. 1998
    ..Different approaches and longer interval screening tests are discussed...
  23. doi Does an organised screening programme reduce the inequalities in breast cancer survival?
    D Puliti
    Clinical and Descriptive Epidemiology Unit, ISPO Cancer Prevention and Research Institute, Florence, Italy
    Ann Oncol 23:319-23. 2012
    ..The aim of the present study was to examine whether the implementation of an organised mammographic screening programme in Florence has been successful in reducing socioeconomic inequalities in breast cancer survival...
  24. ncbi Trends in the prevalence of cervical intraepithelial neoplasia grade 3 in the district of Florence, Italy
    S Cecchini
    Centro per lo Studio e la Prevenzione Oncologica (CSPO, Florence, Italy
    Tumori 81:330-3. 1995
    ..An increase in frequency of precancerous lesions for cervical cancer in more recent birth cohorts supports the need to keep screening coverage and efficiency as high as possible...
  25. ncbi Puberty in perinatal HIV-1 infection: a multicentre longitudinal study of 212 children
    M De Martino
    Department of Paediatrics, University of Florence, Florence, Italy
    AIDS 15:1527-34. 2001
    ..Intervention could save much psychological distress, since associated linear growth failure can exacerbate adolescents' feelings of being different and unwell...
  26. ncbi Time trends in cancer incidence and mortality in central Italy
    E Crocetti
    U O Epidemiologia Clinica e Descrittiva, Centro per lo Studio e la Prevenzione Oncologica, Via di San Salvi 12, 50135 Florence, Italy
    Eur J Cancer Prev 11:387-95. 2002
    ....
  27. pmc Effectiveness of service screening: a case-control study to assess breast cancer mortality reduction
    D Puliti
    Clinical and Descriptive Epidemiology Unit, CSPO, Research Institute of the Tuscany Region, via San Salvi 12, Florence 50135, Italy
    Br J Cancer 99:423-7. 2008
    ..85). The introduction of breast cancer screening programmes in Italy is associated with a reduction in breast cancer mortality attributable to the additional impact of service screening over and above the background access to mammography...
  28. pmc The detectability of breast cancer by screening mammography
    S Ciatto
    Centro per lo Studio e la Prevenzione Oncologica, Florence, Italy
    Br J Cancer 71:337-9. 1995
    ..As diagnostic assessment of minimal lesions is far from being 100% accurate, this policy would also considerably increase the frequency of unnecessary benign biopsies. All these negative effects might turn out to be unacceptable...
  29. ncbi Analysis of PSA velocity in 1666 healthy subjects undergoing total PSA determination at two consecutive screening rounds
    S Ciatto
    Centro per lo Studio e la Prevenzione Oncologica, Florence, Italy
    Int J Biol Markers 17:79-83. 2002
    ..PSAV is widely variable over time, particularly at low PSA values. PSAV might be of value as an indicator for diagnostic assessment and random sextant biopsy in a screening setting...
  30. ncbi Transperineal sonography guided biopsy of the prostate: critical review of 1107 cases
    S Ciatto
    Centro per lo Studio e la Prevenzione Oncologica, Florence, Italy
    Radiol Med 103:219-24. 2002
    ..To assess the predictive value for a positive biopsy of different indicators (rectal examination, transrectal ultrasonography, total PSA, PSA density)...
  31. ncbi An application of the two-source capture-recapture method to estimate the completeness of the Tuscany Cancer Registry, Italy
    E Crocetti
    UO Epidemiologia Clinica e Descrittiva, CSPO, Via di San Salvi 12, 50135 Florence, Italy
    Eur J Cancer Prev 10:417-23. 2001
    ..7% for female breast and 99.6% for lung cancer. With the limit of multiple strong dependence between sources, the two-way capture-recapture method seems a simple and useful tool for estimating the completeness of cancer registration...
  32. ncbi Assessment of the early impact of the population-based breast cancer screening programme in Florence (Italy) using mortality and surrogate measures
    E Paci
    Unit of Evaluative and Clinical Epidemiology, CSPO, Center for Study and Prevention of Cancer, Scientific Institute of the Tuscany Region, 12 Via di S Salvi, 50135, Florence, Italy
    Eur J Cancer 38:568-73. 2002
    ....
  33. ncbi Long-term sequelae of breast cancer surgery
    E Paci
    Centro per lo Studio e la Prevenzione Oncologica, Epidemiological Unit, Florence, Italy
    Tumori 82:321-4. 1996
    ..The impact of these functional problems in terms of quality of life should also be assessed, but it is our impression that there is need for much greater attention to the issue of long-term survivor sequelae...
  34. ncbi Contamination by opportunistic screening in the European Randomized Study of Prostate Cancer Screening
    S Ciatto
    Department Diagnostic Medical Imaging, Centro per lo Studio e la Prevenzione Oncologica, Florence, Italy
    BJU Int 92:97-100. 2003
  35. ncbi Colorectal cancer screening programme by faecal occult blood test in Tuscany: first round results
    G Grazzini
    Secondary Prevention Screening Unit, Regional Reference Centre, Centre for Study and Prevention of Cancer CSPO, Viale Alessandro Volta 171, 50131 Florence, Italy
    Eur J Cancer Prev 13:19-26. 2004
    ..Further efforts are necessary to implement screening extension and to improve data collection...
  36. pmc Comparison of standard and double reading and computer-aided detection (CAD) of interval cancers at prior negative screening mammograms: blind review
    S Ciatto
    Centro per lo Studio e la Prevenzione Oncologica, Viale A Volta 171, I 50131 Florence, Italy
    Br J Cancer 89:1645-9. 2003
    ..9%. The use of CAD as a possible surrogate to conventional DOUBLE needs to be confirmed by further studies, which should include a cost-effective analysis...
  37. pmc Breast density as a determinant of interval cancer at mammographic screening
    S Ciatto
    Centro per lo Studio e la Prevenzione Oncologica, Viale Volta 171, 50131 Firenze, Italy
    Br J Cancer 90:393-6. 2004
    ..Special screening protocols (shorter rescreening interval, routine use of ultrasonography) might be suggested for these subjects in order to improve screening sensitivity and efficacy...
  38. doi Evaluation of service mammography screening impact in Italy. The contribution of hazard analysis
    Eugenio Paci
    Clinical and Descriptive Epidemiology Unit, CSPO, Research Institute of the Tuscany Region, Firenze, Italy
    Eur J Cancer 44:858-65. 2008
    ..96 in the [5-10] year time window, suggesting minimal or any length bias. Consistent with the results of randomised trials, these analyses of service screening data document a mortality reduction of 36% at 5-10 years after diagnosis...
  39. pmc Breast cancer mortality trends in two areas of the province of Florence, Italy, where screening programmes started in the 1970s and 1990s
    G Gorini
    Unit of Occupational and Environmental Epidemiology, Centre for Study and Prevention of Cancer CSPO, Via di S Salvi, Florence 12 50135, Italy
    Br J Cancer 90:1780-3. 2004
    ..The slight decrease in mortality in the LS area (11%) could be mainly due to better care. A reduction of about 30% is attributable to screening in the ES area over the period 1985-2000...
  40. ncbi Basic variables at different positivity thresholds of a quantitative immunochemical test for faecal occult blood
    G Castiglione
    Centro per lo Studio e la Prevenzione Oncologica, Istituto scientifico della Regione Toscana, Viale A Volta 171, I 50131 Firenze, Italy
    J Med Screen 9:99-103. 2002
    ..The latex agglutination test (LAT) has the advantage of being a fully automated, quantitative test. The aim of this study is to interpret the overall experience with LAT according to different positivity thresholds...
  41. ncbi Specific features of the Italian section of the ERSPC
    S Ciatto
    Centro per lo Studio e lo Prevenzione Oncologica, Firenze, Italy
    BJU Int 92:30-2. 2003
  42. pmc Sensitivity of latex agglutination faecal occult blood test in the Florence District population-based colorectal cancer screening programme
    G Castiglione
    Diagnostic Imaging Unit, CSPO, Viale A, Volta 171, Florence 50131, Italy
    Br J Cancer 96:1750-4. 2007
    ..Increasing screening sensitivity might be achieved if the detection rate of advanced adenomas could be increased without unacceptable loss in specificity...
  43. ncbi Effectiveness of influenza vaccination in the elderly in a community in Italy
    E Crocetti
    U O Epidemiologia, Presidio per la Prevenzione Oncologica, Azienda Ospedaliera Careggi, Firenze, Italy
    Eur J Epidemiol 17:163-8. 2001
    ..Estimate the hospitalization fraction preventable by extending the vaccination program...
  44. pmc Surveillance for endometrial cancer with transvaginal ultrasonography of breast cancer patients under tamoxifen treatment
    S Ciatto
    Centro per lo Studio e la Prevenzione Oncologica, Firenze, Italy
    Br J Cancer 88:1175-9. 2003
    ..100, 81.6 or 91.6%; spec.=22.8, 40.4, or 56.7%). Breast cancer patients under tamoxifen might be selected for further invasive assessment on the basis of AUB and endometrial thickness assessed at TVUS...
  45. pmc Association of FOBT-assessed faecal Hb content with colonic lesions detected in the Florence screening programme
    S Ciatto
    Centro per lo Studio e la Prevenzione Oncologica, Viale Volta 171, 50131 Firenze, Italy
    Br J Cancer 96:218-21. 2007
    ..7%) and a high positive predictive value (41.5%). Faecal Hb content is significantly higher for those lesions (cancer and high-risk adenomas) screening is aimed at detecting...
  46. ncbi Clinical impact (cost-effectiveness) of qualifying atypical squamous cells of undeterminate significance (ASCUS) in cases favoring a reactive or dysplastic process
    F M Carozzi
    Analytical and Biomolecular Cytology Unit, Centro per lo Studio e la Prevenzione Oncologica, Florence, Italy
    Diagn Cytopathol 29:4-7. 2003
    ..The evidence that ASCUS detection option implies a higher detection rate of CIN2> and subsequently a lower cost per CIN2> detection must be considered with caution and deserves confirmation by other comparative studies...
  47. doi Use of p16-INK4A overexpression to increase the specificity of human papillomavirus testing: a nested substudy of the NTCC randomised controlled trial
    Francesca Carozzi
    Centre for Cancer Study and Prevention, Florence, Italy
    Lancet Oncol 9:937-45. 2008
    ..We assessed whether HPV testing with triage by p16-INK4A overexpression can increase specificity while maintaining sensitivity...
  48. ncbi Interlaboratory reproducibility of the immunocytochemical assessment of oestrogen and progesterone receptors and proliferative activity in fine needle aspiration of breast cancer
    M Confortini
    Cytopathology Unit, Centro per lo Studio e la Prevenzione Oncologica, Florence, Italy
    Cytopathology 13:92-100. 2002
    ..For Mib1 the results showed some discrepancies. In addition to adequate standardization of procedures, these data confirm that the reliability of the immunocytochemistry is strictly linked to accurate analysis of the results...
  49. ncbi Carbon monoxide, cigarettes and family doctors
    G Invernizzi
    SIMG, Florence, Italy
    Tumori 87:117-9. 2001
    ..The study was aimed to investigate the awareness of a sample of Italian family doctors as regards tobacco epidemiology and smoking cessation strategies...
  50. ncbi Different kinetics of immunologic recovery using nelfinavir or lopinavir/ritonavir-based regimens in children with perinatal HIV-1 infection
    M De Luca
    Department of Paediatrics, University of Florence, Florence, Italy
    Int J Immunopathol Pharmacol 18:729-35. 2005
    ....
  51. ncbi Prognostic impact of the early detection of metachronous contralateral breast cancer
    Stefano Ciatto
    Centro per lo Studio e la Prevenzione Oncologica, Viale A Volta 171, 50131 Florence, Italy
    Eur J Cancer 40:1496-501. 2004
    ..Although length bias may have occurred (symptomatic MCBC had a shorter free interval from the first cancer), the present evidence supports the practice of active follow-up aimed at the early detection of asymptomatic MCBC...
  52. ncbi Comparing attendance and detection rate of colonoscopy with sigmoidoscopy and FIT for colorectal cancer screening
    Nereo Segnan
    CPO Piemonte, Torino, Italy
    Gastroenterology 132:2304-12. 2007
    ..We conducted a study to estimate population coverage and detection rate (DR) achievable through different strategies of colorectal cancer (CRC) screening...
  53. ncbi Screening for colorectal cancer in Italy: 2006 survey
    Manuel Zorzi
    Registro Tumori Veneto, Istituto Oncologico Veneto IRCCS, Padova
    Epidemiol Prev 32:55-68. 2008
    ..However, reported experiences showed good results in terms of attendance and DR, although some critical aspects need to be carefully addressed when planning and implementing screening activity...
  54. ncbi The New Technologies for Cervical Cancer Screening randomised controlled trial. An overview of results during the first phase of recruitment
    Guglielmo Ronco
    Centro per la Prevenzione Oncologica CPO, Torino, Italy
    Gynecol Oncol 107:S230-2. 2007
    ..To study the impact of different cervical cancer screening strategies including HPV testing...
  55. ncbi PSA use and incidence of prostate biopsy in the Tuscany region: is opportunistic screening discounting biopsy in subjects with PSA elevation?
    Stefano Ciatto
    CSPO, Istituto Scientifico per la Prevenzione Oncologica, Florence, Italy
    Tumori 94:518-22. 2008
    ..To assess PSA use in the general population and estimate biopsy rate subsequent to opportunistic screening...
  56. pmc Agreement between the AMPLICOR Human Papillomavirus Test and the Hybrid Capture 2 assay in detection of high-risk human papillomavirus and diagnosis of biopsy-confirmed high-grade cervical disease
    Francesca Carozzi
    Centro per lo Studio e la Prevenzione Oncologica, Unità Operativa Citologia Analitica e Molecolare, Via Cosimo il Vecchio 2, 50127 Firenze, Italy
    J Clin Microbiol 45:364-9. 2007
    ..7% of cases, while 21% of cases were negative. In conclusion, AMP provides a viable alternative to HC2, with good agreement for samples with high-grade cytology and similar sensitivity in detecting CIN2+ lesions...
  57. ncbi "Does fecal occult blood testing really reduce mortality? A reanalysis of systematic review data." by Moayyedi P and Achkar E
    Marco Zappa
    Am J Gastroenterol 101:2433; author reply 2433-4. 2006
  58. ncbi Extension of organised cervical cancer screening programmes in Italy and their process indicators
    Guglielmo Ronco
    CPO Piemonte, Torino
    Epidemiol Prev 31:33-47. 2007
    ..The unadjusted detection rate ofhistologically confirmed CIN2 or more severe was 2.7 per 1000 screened women (3.0 per 1000, standardised on the Italian population, truncated 25-64)...
  59. ncbi [Recommendations of a national Italian consensus conference on the opportunity of extending screening service by mammography to 40-49 and 70-74 years of age women]
    Vito Distante
    SOD Chirurgia generale II, AO universitaria, Careggi, Firenze
    Epidemiol Prev 31:15-22. 2007
    ....
  60. ncbi The impact of new technologies in cervical cancer screening: results of the recruitment phase of a large randomised controlled trial from a public health perspective
    Paolo Giorgi-Rossi
    Agency for Public Health, Lazio Region, Rome, Italy
    Int J Cancer 121:2729-34. 2007
    ..If HPV testing is applied with cytology-triage, a single HPV test may cost 20-30% more than a conventional Pap to result in the same overall cost per CIN2+ detected...
  61. ncbi Mammography screening in Italy: 2005 survey and 2006 preliminary data
    Daniela Giorgi
    UO Epidemiologia, ASL 2 Lucca, Istituto Tumori Toscano
    Epidemiol Prev 32:7-22. 2008
    ....
  62. ncbi Mammography screening in Italy: 2004 survey and 2005 preliminary data
    Daniela Giorgi
    UO Epidemiologia, ASL 2 Lucca
    Epidemiol Prev 31:7-20. 2007
    ..3% received an invitation to have a mammography. Imbalance in coverage still exists between Northern and Central Italy and the South: figures are 92.4%, 98.6%, and 39.3%. The national crude attendance rate was 5 7.8%...
  63. ncbi National Centre for Screening Monitoring. Sixth report. Introduction
    Marco Zappa
    National Centre for Screening Monitoring
    Epidemiol Prev 32:5-6. 2008
  64. ncbi Breast cancer diagnostic methods: screen-detected and clinical cases. An Italian survey of women's experiences
    Paolo Giorgi Rossi
    Agency for Public Health, Lazio Region, Rome, Italy
    Tumori 93:452-60. 2007
    ....
  65. doi Results at recruitment from a randomized controlled trial comparing human papillomavirus testing alone with conventional cytology as the primary cervical cancer screening test
    Guglielmo Ronco
    Unit of Cancer Epidemiology, Centro per la Prevenzione Oncologica, Turin, Italy
    J Natl Cancer Inst 100:492-501. 2008
    ..HPV-positive women were directly referred to colposcopy if aged 35 or older; if younger, they were retested after 1 year...
  66. ncbi The cytological screening turned out effective also for adenocarcinoma: a population-based case-control study in Trento, Italy
    Emanuele Crocetti
    Clinical and Descriptive Epidemiology Unit, Centre for the Study and Prevention of Cancer, Scientific Institute of the Tuscan Region, Florence, Italy
    Eur J Cancer Prev 16:564-7. 2007
    ..Our study confirms that Pap-test screening, particularly in middle-aged and older women, is an effective public health intervention with encouraging results also for the prevention of cervical adenocarcinoma...
  67. ncbi [Interval cancers as indicators of performance in screening programmes]
    Stefano Ciatto
    Epidemiol Prev 32:93-8. 2008
    ....
  68. ncbi Activity level and process indicators of organised programmes for cervical cancer screening in Italy
    Guglielmo Ronco
    Centro Prevenzione Oncologica, Torino
    Epidemiol Prev 30:27-40. 2006
    ..Despite this rise, quality indicators were stable. However, in a few programmes, the use of excessively broad criteria in the interpretation of cytology decides an excessively high rate of referrals to colposcopy...
  69. ncbi Determining overdiagnosis by screening with DRE/TRUS or PSA (Florence pilot studies, 1991-1994)
    Stefano Ciatto
    Centro per lo Studio e la Prevenzione Oncologica, Viale A Volta 171, 50131 Florence, Italy
    Eur J Cancer 41:411-5. 2005
    ..23 in subjects excluded from invitation due to previous cancer or major illness (95%CI=0.8-1.5). A 66% excess incidence rate was observed in the screened subjects over a 9-year period, confirming previous estimates of overdiagnosis...
  70. ncbi Exposure to benzene and risk of leukemia among shoe factory workers
    Adele Seniori Costantini
    Unit of Occupational Environmental Epidemiology, Centro per lo Studio e la Prevenzione Oncologica, Florence, Italy
    Scand J Work Environ Health 29:51-9. 2003
    ....
  71. ncbi Triage with human papillomavirus testing of women with cytologic abnormalities prompting referral for colposcopy assessment
    Francesca Maria Carozzi
    Analytical and Biomolecular Cytology Unit, Centro per lo Studio e la Prevenzionc Oncologica, Florence, Italy
    Cancer 105:2-7. 2005
    ..The current study was conducted to evaluate the cost-effectiveness of triaging for colposcopy using human papillomavirus (HPV) testing...
  72. ncbi Association of endometrial thickness assessed at trans-vaginal ultrasonography to endometrial cancer in postmenopausal women asymptomatic or with abnormal uterine bleeding
    Stefano Ciatto
    Centro per lo Studio e la Prevenzione Oncologica, Ferrara, Italy
    Radiol Med 104:437-42. 2002
    ..To define the normal cut off of endometrial thickness as measured at transvaginal ultrasonography (TVUS) in order to define postmenopausal women without symptoms or with abnormal uterine bleeding (AUB) at risk of endometrial carcinoma (EC)...
  73. ncbi Persistent human papilloma virus infection as an indicator of risk of recurrence of high-grade cervical intraepithelial neoplasia treated by the loop electrosurgical excision procedure
    Silvia Cecchini
    Centro per lo Studio e la Prevenzione Oncologica, Florence, Italy
    Tumori 90:225-8. 2004
    ..To evaluate the recurrence rate of high-grade cervical intraepithelial neoplasia (CIN) treated by the loop electrosurgical excision procedure (LEEP) according to the persistence of human papilloma virus (HPV) infection...
  74. ncbi Recurrence after treatment by loop electrosurgical excision procedure (LEEP) of high-grade cervical intraepithelial neoplasia
    Silvia Cecchini
    Centro per lo Studio e la Prevenzione Oncologica, Florence, Italy
    Tumori 88:478-80. 2002
    ..To evaluate the recurrence rate of high-grade CIN treated by loop electrosurgical excision procedure (LEEP) and the optimal follow-up schedule...
  75. ncbi Determining the sensitivity of transrectal ultrasonography on a consecutive series of prostate cancers in a clinical and screening setting
    Stefano Ciatto
    Tumori 88:281-3. 2002
    ..To evaluate the sensitivity at transrectal ultrasonography (TRUS) for prostate cancer...
  76. ncbi Comparison of standard reading and computer aided diagnosis (CAD) on a proficiency test of screening mammography
    Stefano Ciatto
    Centro per lo Studio e la Prevenzione Oncologica, Firenze, Italy
    Radiol Med 106:59-65. 2003
    ..To evaluate the role of computer aided diagnosis (CAD) to improve screening mammograms interpretation...
  77. ncbi A feasibility study of the use of the AutoPap screening system as a primary screening and location-guided rescreening device
    Massimo Confortini
    Cytology Unit, Centro per lo Studio e la Prevenzione Oncologica, Florence, Italy
    Cancer 99:129-34. 2003
    ..Burlington, NC) is an automated device that was designed to screen conventionally prepared cervical smears and, more recently, thin-layer slide preparations. The system has been tested in large clinical trials...
  78. ncbi Randomized trial of different screening strategies for colorectal cancer: patient response and detection rates
    Nereo Segnan
    Centro Prevenzione Oncologica Regione Piemonte and Azienda Sanitaria Ospedaliera S Giovanni Battista, Torino, Italy
    J Natl Cancer Inst 97:347-57. 2005
    ..We compared the participation and detection rates achievable through different strategies of colorectal cancer screening...
  79. ncbi [Lecture on the evaluation of technologies, but with what kind of teaching?]
    Eugenio Paci
    Unita operativa di epidemiologia clinica e descrittiva, CSPO Firenze
    Epidemiol Prev 26:276-7. 2002
  80. ncbi Incidence trends of adenocarcinoma of the cervix in 13 European countries
    Freddie Bray
    Cancer Registry of Norway, Montebello, Oslo
    Cancer Epidemiol Biomarkers Prev 14:2191-9. 2005
    ..Screening may have had at least some impact in reducing cervical adenocarcinoma incidence in several countries during the 1990s...
  81. ncbi Prostate cancer specific mortality in the Florence screening pilot study cohort 1992-1993
    Stefano Ciatto
    Centro per lo Studio e la Prevenzione Oncologica, Viale A Volta 171, 50131 Firenze, Italy
    Eur J Cancer 42:1858-62. 2006
    ..99; 95% CI=0.69-1.37). This finding might suggest a screening effect, but might also be ascribed to an healthy screening effect, and cannot be assumed as a reliable evidence of screening efficacy...
  82. ncbi Human papillomavirus testing and liquid-based cytology: results at recruitment from the new technologies for cervical cancer randomized controlled trial
    Guglielmo Ronco
    Unit of Cancer Epidemiology, Centro per la Prevenzione Oncologica Piemonte, 10123 Turin, Italy
    J Natl Cancer Inst 98:765-74. 2006
    ....
  83. ncbi [Estimates of cancer incidence in Tuscany, year 2000. Between method accuracy and communication appropriateness]
    Guido Miccinesi
    Centro per lo Studio e la Prevenzione Oncologica, Via di San Salvi 12, 50135 Firenze
    Epidemiol Prev 26:176-82. 2002
    ....
  84. ncbi Baseline findings of the Italian multicenter randomized controlled trial of "once-only sigmoidoscopy"--SCORE
    Nereo Segnan
    Unit of Epidemiology, Centro per la Prevenzione Oncologica Piemonte, Azienda Sanitaria Ospedaliero S Giovanni Batista, Via S Francesco da Paola 31, Piemonte, 10123 Turin, Italy
    J Natl Cancer Inst 94:1763-72. 2002
    ..We present the baseline screening outcomes...
  85. ncbi Increasing trends of cervical adenocarcinoma incidence in Central Italy despite Extensive Screening Programme, 1985-2000
    Carmen B Visioli
    Descriptive and Epidemiological Unit, Center for Study and Prevention of Cancer CSPO, Via di San Salvi, 12, 50135 Florence, Italy
    Cancer Detect Prev 28:461-4. 2004
    ..The burden of cervical cancers might increase in the future if no specific preventive strategies for adenocarcinoma are implemented...
  86. ncbi Re: Role of detection method in predicting breast cancer survival: analysis of randomized screening trials
    Eugenio Paci
    J Natl Cancer Inst 97:1853-4; author reply 1854. 2005
  87. ncbi Re: Efficacy of breast cancer screening in the community according to risk level
    Eugenio Paci
    J Natl Cancer Inst 97:1704; author reply 1704-5. 2005
  88. ncbi Early diagnosis, not differential treatment, explains better survival in service screening
    Eugenio Paci
    Unit of Clinical and Descriptive Epidemiology, Centre for Study and Prevention of Cancer, Research Institute of Tuscany Region, Via di San Salvi 12, 50125 Firenze, Florence, Italy
    Eur J Cancer 41:2728-34. 2005
    ..The survival analysis by specific subgroups did not support the hypothesis that the difference in prognosis was attributable to differential treatment...
  89. pmc Are breast cancer screening programmes increasing rates of mastectomy? Observational study
    Eugenio Paci
    Unit of Epidemiology, Centre for the Study and Prevention of Cancer CSPO, Via di S Salvi 12, 50135 Florence, Italy
    BMJ 325:418. 2002
  90. ncbi Risk-benefit analysis of X-ray exposure associated with lung cancer screening in the Italung-CT trial
    Mario Mascalchi
    Sezione di Radiodiagnostica, Dipartimento di Fisiopatologia Clinica, Universita di Firenze, Viale Morgagni 85, 50134 Firenze, Italia
    AJR Am J Roentgenol 187:421-9. 2006
    ....
  91. ncbi Comparison of the conventional cervical smear and liquid-based cytology: results of a controlled, prospective study in the Abruzzo Region of Italy
    Vincenzo Maccallini
    Pathology Unit, Annunziata Hospital, Cervical Cancer Screening Program, Abruzzo Region, Sulmona
    Acta Cytol 52:568-74. 2008
    ..To compare conventional cervical testing (CCT) and liquid-based cytology (LBC) within a randomized trial performed during 2001-2002 in the Abruzzo Region of Italy, including a cost-outcome comparative analysis...
  92. ncbi Extension of organised cervical cancer screening programmes in Italy and their process indicators
    Guglielmo Ronco
    CPO Piemonte, Torino
    Epidemiol Prev 32:37-54. 2008
    ..The unadjusted detection rate of histologically confirmed CIN2 or more severe was 2.7 per 1,000 screened women (2.6 standardised on the Italian population, truncated 25-64)...
  93. ncbi [Some reflexions on ethics in oncological screening]
    Caterina Ferrari
    Centro per lo Studio e la Prevenzione Oncologica, Istituto scientifico della Regione Toscana
    Epidemiol Prev 26:303-6. 2002
  94. ncbi Digital images for interobserver variability comparison in cervicovaginal cytology
    Galliano Tinacci
    Division of Pathology, Hospital Alberti, Arezzo, Italy
    Anal Quant Cytol Histol 25:1-7. 2003
    ..To assess whether digital images can be useful in evaluating interobserver variability in cervical-vaginal cytology...
  95. doi Increased expression and activity of the transcription factor FOXO1 in nonalcoholic steatohepatitis
    Luca Valenti
    Department of Internal Medicine, Ospedale Maggiore Policlinico Mangiagalli Regina Elena IRCCS Istituto di Ricovero e Cura a Carattere Scientifico, University of Milan, Milan, Italy
    Diabetes 57:1355-62. 2008
    ....
  96. ncbi Role of ultrasound-guided fine needle cytology of axillary lymph nodes in breast carcinoma staging
    Beniamino Brancato
    Centro per lo Studio e la Prevenzione Oncologica, Firenze, Italy
    Radiol Med 108:345-55. 2004
    ..To evaluate the efficacy of cytology on axillary lymph node ultrasound-guided aspiration biopsy in the reduction of inappropriate surgery, such as the sentinel node (SN) procedure if positive, or axillary dissection if negative...
  97. ncbi History of negative colorectal endoscopy and risk of rectosigmoid neoplasms at screening flexible sigmoidoscopy
    Luigina Bonelli
    Secondary Prevention and Screening, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Int J Colorectal Dis 21:105-13. 2006
    ....
  98. ncbi Prognostic significance of p53 and Ki-67 antigen expression in surgically treated non-small cell lung cancer: immunocytochemical detection with imprint cytology
    Cristina Maddau
    Cytopathology Unit, Center for Study and Cancer Prevention, Florence, Italy
    Am J Clin Pathol 125:425-31. 2006
    ....
  99. ncbi Mortality among discharged psychiatric patients in Florence, Italy
    Debora Meloni
    Neurological and Psychiatric Sciences Department, University of Florence, Viale Morgagni 85, Florence 50140, Italy
    Psychiatr Serv 57:1474-81. 2006
    ....
  100. ncbi Conventional pap smear and liquid-based cervical cytology smear: comparison from the same patient
    Massimo Confortini
    Cytopathology Unit, Borgo San Lorenzo Hospital, Florence, Italy
    Tumori 88:288-90. 2002
    ..The results of blind reading of smears obtained with liquid-based cytology in patients previously screened by conventional cytology were compared...