Michele Spina

Summary

Affiliation: Centro di Riferimento Oncologico
Country: Italy

Publications

  1. doi request reprint Phase 2 study of intrathecal, long-acting liposomal cytarabine in the prophylaxis of lymphomatous meningitis in human immunodeficiency virus-related non-Hodgkin lymphoma
    Michele Spina
    Division of Medical Oncology A, National Cancer Institute, Via Franco Gallini 2, 33081 Aviano PN Italy
    Cancer 116:1495-501. 2010
  2. pmc Modulated chemotherapy according to modified comprehensive geriatric assessment in 100 consecutive elderly patients with diffuse large B-cell lymphoma
    Michele Spina
    Division of Medical Oncology A, National Cancer Institute, Via Franco Gallini 2, Aviano, PN, Italy
    Oncologist 17:838-46. 2012
  3. ncbi request reprint Virological efficacy in HIV-infected patients affected by non-Hodgkin lymphoma, treated with antiblastic chemotherapy and highly active antiretroviral therapy
    Cecilia Simonelli
    Divisione di Oncologia Medica A, Istituto Nazionale Tumori, Aviano, Italy
    Scand J Infect Dis Suppl 106:49-53. 2003
  4. ncbi request reprint Characterization of immunologic and virological parameters in HIV-infected patients with primary effusion lymphoma during antiblastic therapy and highly active antiretroviral therapy
    Cecilia Simonelli
    Division of Medical Oncology A, National Cancer Institute, Aviano, Italy
    Clin Infect Dis 40:1022-7. 2005
  5. ncbi request reprint Rituximab plus infusional cyclophosphamide, doxorubicin, and etoposide in HIV-associated non-Hodgkin lymphoma: pooled results from 3 phase 2 trials
    Michele Spina
    Division of Medical Oncology A, National Cancer Institute, Via Pedemontana Occidentale 12, 33081, Aviano PN Italy
    Blood 105:1891-7. 2005
  6. ncbi request reprint Oxaliplatin based chemotherapy and concomitant highly active antiretroviral therapy in the treatment of 24 patients with colorectal cancer and HIV infection
    Massimiliano Berretta
    Department of Medical Oncology, National Cancer Institute Centro di Riferimento Oncologico, IRCCS, 33081 Aviano PN, Italy
    Curr HIV Res 8:218-22. 2010
  7. ncbi request reprint Clinical features and outcome of primary effusion lymphoma in HIV-infected patients: a single-institution study
    Cecelia Simonelli
    Division of Medical Oncology A, National Cancer Institute, Aviano, Italy
    J Clin Oncol 21:3948-54. 2003
  8. ncbi request reprint Outcome in patients with non-hodgkin lymphoma and with or without human immunodeficiency virus infection
    Michele Spina
    Division of Medical Oncology A, National Cancer Institute, Aviano, Italy
    Clin Infect Dis 38:142-4. 2004
  9. ncbi request reprint The impact of tobacco smoking and alcohol drinking on survival of patients with non-Hodgkin lymphoma
    Renato Talamini
    Unit of Epidemiology and Biostatistics, National Cancer Institute, Aviano, Italy
    Int J Cancer 122:1624-9. 2008
  10. doi request reprint Can the caregiver replace his/her elderly cancer patient in the physician-patient line of communication?
    Annalisa Giacalone
    Division of Medical Oncology A, National Cancer Institute, Via Franco Gallini 2, 33081, Aviano PN, Italy
    Support Care Cancer 16:1157-62. 2008

Collaborators

Detail Information

Publications30

  1. doi request reprint Phase 2 study of intrathecal, long-acting liposomal cytarabine in the prophylaxis of lymphomatous meningitis in human immunodeficiency virus-related non-Hodgkin lymphoma
    Michele Spina
    Division of Medical Oncology A, National Cancer Institute, Via Franco Gallini 2, 33081 Aviano PN Italy
    Cancer 116:1495-501. 2010
    ..Patients with human immunodeficiency virus (HIV)-NHL often develop CNS progression despite the use of prophylaxis. Liposomal cytarabine (DepoCyte) has shown activity in lymphomatous meningitis, but there are limited data for prophylaxis...
  2. pmc Modulated chemotherapy according to modified comprehensive geriatric assessment in 100 consecutive elderly patients with diffuse large B-cell lymphoma
    Michele Spina
    Division of Medical Oncology A, National Cancer Institute, Via Franco Gallini 2, Aviano, PN, Italy
    Oncologist 17:838-46. 2012
    ..Wide use of this CGA-driven treatment may result in better cure rates, especially in fit and unfit patients...
  3. ncbi request reprint Virological efficacy in HIV-infected patients affected by non-Hodgkin lymphoma, treated with antiblastic chemotherapy and highly active antiretroviral therapy
    Cecilia Simonelli
    Divisione di Oncologia Medica A, Istituto Nazionale Tumori, Aviano, Italy
    Scand J Infect Dis Suppl 106:49-53. 2003
    ..The data show that a combination therapy consisting of CT and HAART is feasible and that the virological response can be maintained in the majority of such patients...
  4. ncbi request reprint Characterization of immunologic and virological parameters in HIV-infected patients with primary effusion lymphoma during antiblastic therapy and highly active antiretroviral therapy
    Cecilia Simonelli
    Division of Medical Oncology A, National Cancer Institute, Aviano, Italy
    Clin Infect Dis 40:1022-7. 2005
    ..The aim of the present study was to evaluate the immunologic and virological parameters, including HHV-8 viremia, of 5 HIV-infected patients with PEL whose disease was diagnosed and treated at our institute...
  5. ncbi request reprint Rituximab plus infusional cyclophosphamide, doxorubicin, and etoposide in HIV-associated non-Hodgkin lymphoma: pooled results from 3 phase 2 trials
    Michele Spina
    Division of Medical Oncology A, National Cancer Institute, Via Pedemontana Occidentale 12, 33081, Aviano PN Italy
    Blood 105:1891-7. 2005
    ..Further studies evaluating rituximab in combination with infusional chemotherapy are warranted, but caution is advised...
  6. ncbi request reprint Oxaliplatin based chemotherapy and concomitant highly active antiretroviral therapy in the treatment of 24 patients with colorectal cancer and HIV infection
    Massimiliano Berretta
    Department of Medical Oncology, National Cancer Institute Centro di Riferimento Oncologico, IRCCS, 33081 Aviano PN, Italy
    Curr HIV Res 8:218-22. 2010
    ..The results were analyzed to evaluate feasibility and activity of FOLFOX4 plus highly active antiretroviral therapy (HAART) in metastatic CRC (mCRC) HIV-seropositive patients...
  7. ncbi request reprint Clinical features and outcome of primary effusion lymphoma in HIV-infected patients: a single-institution study
    Cecelia Simonelli
    Division of Medical Oncology A, National Cancer Institute, Aviano, Italy
    J Clin Oncol 21:3948-54. 2003
    ..To describe the clinical features and outcome of HIV-associated primary effusion lymphoma (PEL) and to compare them with those of the other HIV-associated non-Hodgkin's lymphomas (NHLs)...
  8. ncbi request reprint Outcome in patients with non-hodgkin lymphoma and with or without human immunodeficiency virus infection
    Michele Spina
    Division of Medical Oncology A, National Cancer Institute, Aviano, Italy
    Clin Infect Dis 38:142-4. 2004
    ..4 for HIV-infected patients vs. 1 for HIV-negative patients; P=.24). Therefore, the achievement of complete remission should be the main goal in the treatment of patients with HIV-NHL...
  9. ncbi request reprint The impact of tobacco smoking and alcohol drinking on survival of patients with non-Hodgkin lymphoma
    Renato Talamini
    Unit of Epidemiology and Biostatistics, National Cancer Institute, Aviano, Italy
    Int J Cancer 122:1624-9. 2008
    ..Our findings strongly encourage physicians to advice NHL patients to stop smoking and diminish alcohol consumption to obtain improvements in the course of NHL...
  10. doi request reprint Can the caregiver replace his/her elderly cancer patient in the physician-patient line of communication?
    Annalisa Giacalone
    Division of Medical Oncology A, National Cancer Institute, Via Franco Gallini 2, 33081, Aviano PN, Italy
    Support Care Cancer 16:1157-62. 2008
    ..GOALS OF WORKS: Only few studies have focussed on the information needs of senior cancer patients. The aim of this study was to evaluate to what extent caregivers perceive their elderly cancer patients' informational needs...
  11. ncbi request reprint Therapeutic approaches to AIDS-related malignancies
    Massimiliano Berretta
    Division of Medical Oncology A, Centro di Riferimento Oncologico, National Cancer Institute, via Pedemontana Occ le 12, Aviano PN 33081, Italy
    Oncogene 22:6646-59. 2003
    ....
  12. ncbi request reprint Improvement of systemic human immunodeficiency virus-related non-Hodgkin lymphoma outcome in the era of highly active antiretroviral therapy
    Emanuela Vaccher
    Division of Medical Oncology A, National Cancer Institute, Aviano, Italy
    Clin Infect Dis 37:1556-64. 2003
    ..42-40.25), 9.11 (95% CI, 3.71-22.32), and 8.54 (95% CI, 1.19-61.11), respectively. Our study suggests that the long-term use of HAART may favorably change the outcome for patients with systemic HIV-NHL...
  13. ncbi request reprint Impact of concomitant antiblastic chemotherapy and highly active antiretroviral therapy on human immunodeficiency virus (HIV) viremia and genotyping in HIV-infected patients with non-Hodgkin lymphoma
    Cecilia Simonelli
    Division of Medical Oncology A, National Cancer Institute, Aviano, Italy
    Clin Infect Dis 37:820-7. 2003
    ..Our data show that combination therapy consisting of CT and HAART is feasible and that the virological response can be maintained in the majority of patients receiving this treatment...
  14. doi request reprint Immune recovery after autologous stem cell transplantation is not different for HIV-infected versus HIV-uninfected patients with relapsed or refractory lymphoma
    Cecilia Simonelli
    Division of Medical Oncology A, National Cancer Institute, Aviano, Italy
    Clin Infect Dis 50:1672-9. 2010
    ..The aims of our study were to assess the impact of conventional chemotherapy before salvage treatment was administered, in this population, and to evaluate immune reconstitution dynamics during ASCT...
  15. ncbi request reprint Dietary folate, alcohol consumption, and risk of non-Hodgkin lymphoma
    Jerry Polesel
    Unita di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Aviano, Italy
    Nutr Cancer 57:146-50. 2007
    ..However, the lack of an overall effect for one-carbon nutrients and the small sample size suggested caution in interpreting our results...
  16. doi request reprint Cancer in the elderly: the caregivers' perception of senior patients' informational needs
    Annalisa Giacalone
    Division of Medical Oncology A, National Cancer Institute, Centro di Riferimento Oncologico, Via Franco Gallini 2, 33081 Aviano, PN, Italy
    Arch Gerontol Geriatr 49:e121-5. 2009
    ..Interventions, both to help senior patients express their needs and to improve the patient-to-doctor-to-caregiver communication about cancer diseases, are necessary...
  17. ncbi request reprint Stanford V regimen and concomitant HAART in 59 patients with Hodgkin disease and HIV infection
    Michele Spina
    Division of Medical Oncology A, National Cancer Institute, Via Pedemontana Occidentale 12, 33081 Aviano PN, Italy
    Blood 100:1984-8. 2002
    ..Our data confirm that the Stanford V regimen with concomitant HAART is feasible and active in an HIV setting. However, a more intensive approach should be considered in patients with high IPSs...
  18. ncbi request reprint Rituximab for HIV-associated lymphoma: weighing the benefits and risks
    Michele Spina
    Division of Medical Oncology A, National Cancer Institute, Via Pedemontana Occidentale 12, 33081 Aviano, PN, Italy
    Curr Opin Oncol 17:462-5. 2005
    ..This review discusses the potential benefits and risks of using the anti-CD20 monoclonal antibody rituximab for the treatment of HIV-associated B-cell non-Hodgkin's lymphoma...
  19. doi request reprint FOLFOX-4 regimen with concomitant highly active antiretroviral therapy in metastatic colorectal cancer HIV-infected patients: a report of five cases and review of the literature
    Massimiliano Berretta
    Division of Medical Oncology A, National Cancer Institute, Aviano, Italy
    Cancer Invest 26:610-4. 2008
    ..Moreover, the concomitant use of HAART does not seem to increase the toxicity of the FOLFOX-4 regimen...
  20. ncbi request reprint Non-Hodgkin's lymphoma and hepatitis C virus: a case-control study from northern and southern Italy
    Renato Talamini
    Servizio di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Aviano, Pordenone, Italy
    Int J Cancer 110:380-5. 2004
    ..In conclusion, HCV infection was associated with an increase in NHL risk, and the fraction of NHL cases attributable to HCV was 12.4% (range 6.3-18.5%)...
  21. doi request reprint Management of immunocompetent patients with primary central nervous system lymphoma
    Emanuela Chimienti
    Division of Medical Oncology, National Cancer Institute, Aviano, Italy
    Clin Lymphoma Myeloma 9:353-64. 2009
    ..Combined-modality therapy has improved survival, but relapse is still common, and late neurologic toxicity is a significant complication, especially in older patients, who represent the majority of immunocompetent patients with PCNSL...
  22. ncbi request reprint Aggressive forms of non-Hodgkin's lymphoma in two patients bearing coinfection of Epstein-Barr and hepatitis C viruses
    Massimo Libra
    Division of Experimental Oncology 1, Centro di Riferimento Oncologico Aviano, Istituto Nazionale Tumori, IRCCS, Via Pedemontana Occidentale 12, I 33081 Aviano, PN, Italy
    Int J Oncol 26:945-50. 2005
    ..Together, these data suggest that EBV infection may cooperate with HCV infection during progression of B-cell NHL in immunocompetent individuals. Such an interaction may accelerate the course of disease in B-cell NHL patients...
  23. ncbi request reprint Hodgkin's disease in HIV
    Michele Spina
    Division of Medical Oncology A, National Cancer Institute, via Pedemontana Occ le 12, 33081 Aviano PN, Italy
    Hematol Oncol Clin North Am 17:843-58. 2003
    ....
  24. doi request reprint Recent prognostic factors in diffuse large B-cell lymphoma indicate NF-kappaB pathway as a target for new therapeutic strategies
    Alessandro Pavan
    Department of Experimental and Clinical Pharmacology, Centro di Riferimento Oncologico, IRCCS, National Cancer Institute, Aviano, Italy
    Leuk Lymphoma 49:2048-58. 2008
    ..In this review, the NF-kappaB pathway is suggested as a target for new chemotherapy strategies based on the association of CHOP with molecules more effective than rituximab in this pathway inhibition...
  25. doi request reprint Classical Hodgkin's lymphoma arising in different host's conditions: pathobiology parameters, therapeutic options, and outcome
    Antonino Carbone
    Division of Pathology, Centro di Riferimento Oncologico Aviano, Istituto Nazionale Tumori, Aviano, Italy
    Am J Hematol 86:170-9. 2011
    ..Refractory CHL, a clinical condition that may occur throughout the entire spectrum of CHL, is discussed separately...
  26. doi request reprint Massive myocardial infiltration by HIV-related non-Hodgkin lymphoma: echocardiographic aspects at diagnosis and at follow-up
    Chiara Lestuzzi
    Cardiology Unit, National Cancer Institute, Via Gallini 2, Aviano PN, Italy
    J Cardiovasc Med (Hagerstown) 13:836-8. 2012
    ..In the HAART era patients with HIV-related lymphoma and even massive involvement of the heart may receive aggressive treatment with curative intent. Echocardiography is useful in early assessment of the response to therapy...
  27. doi request reprint IGKV3 proteins as candidate "off-the-shelf" vaccines for kappa-light chain-restricted B-cell non-Hodgkin lymphomas
    Debora Martorelli
    Cancer Bio Immunotherapy Unit, IRCCS National Cancer Institute, Aviano, Italy
    Clin Cancer Res 18:4080-91. 2012
    ..An increasing set of B-cell non-Hodgkin lymphomas (B-NHL) show a biased usage of IGKV3-20 and IGKV3-15 immunoglobulin genes, a feature that could be exploited for the development of ready-to-use, broadly applicable cancer vaccines...
  28. ncbi request reprint Protein expression profile of celiac disease patient with aberrant T cell by two-dimensional difference gel electrophoresis
    Valli De Re
    Experimental and Clinical Farmacology Unit, DOMERT Department, Centro di Riferimento Oncologico, IRCCS, National Cancer Institute, Aviano PN, Italy
    Ann N Y Acad Sci 1109:429-40. 2007
    ..Results also emphasize the possible association of apolipoprotein with aberrant T cell proliferation...
  29. ncbi request reprint AIDS-related tumors: integrating antiviral and anticancer therapy
    Umberto Tirelli
    Division of Medical Oncology A, National Cancer Institute, via Pedemontana Occ le 12, Aviano PN 33081, Italy
    Crit Rev Oncol Hematol 41:299-315. 2002
    ....
  30. doi request reprint Distinct functional significance of Akt and mTOR constitutive activation in mantle cell lymphoma
    Jessica Dal Col
    Cancer Bio Immunotherapy Unit, Department of Medical Oncology, Centro di Riferimento Oncologico CRO, Istituto di Ricovero e Cura a Caratiere Scientifico IRCCS National Cancer Institute, Aviano, Italy
    Blood 111:5142-51. 2008
    ..These results indicate that Akt and mTOR activation have distinct functional relevance in MCL and suggest that targeting Akt may result in more effective therapeutic effects compared with mTOR inhibition...