A Ghezzi

Summary

Affiliation: Centro Studi Sclerosi Multipla
Country: Italy

Publications

  1. doi request reprint Chronic cerebro-spinal venous insufficiency (CCSVI) and multiple sclerosis
    A Ghezzi
    Centro Studi Sclerosi Multipla, Ospedale di Gallarate, Coordinator of Multiple Sclerosis Study Group, Italian Society of Neurology, Gallarate, Italy
    Neurol Sci 32:17-21. 2011
  2. doi request reprint Current recommendations for multiple sclerosis treatment in pregnancy and puerperium
    Angelo Ghezzi
    UO Neurologia 2 Centro Studi Sclerosi Multipla, Ospedale di Gallarate, Via Pastori 4, 21013 Gallarate, Italy
    Expert Rev Clin Immunol 9:683-91; quiz 692. 2013
  3. ncbi request reprint Endovascular treatment of CCSVI in patients with multiple sclerosis: clinical outcome of 462 cases
    A Ghezzi
    Centro Studi Sclerosi Multipla, Ospedale di Gallarate, Gallarate, Italy
    Neurol Sci 34:1633-7. 2013
  4. pmc Epidural analgesia and cesarean delivery in multiple sclerosis post-partum relapses: the Italian cohort study
    Luisa Pastò
    Department of Neurology, University of Florence, Viale Morgagni 85, 50134, Florence, Italy
    BMC Neurol 12:165. 2012
  5. pmc Pregnancy and fetal outcomes after Glatiramer Acetate exposure in patients with multiple sclerosis: a prospective observational multicentric study
    Marta Giannini
    Department of Neurology, University of Florence, Florence, Italy
    BMC Neurol 12:124. 2012
  6. doi request reprint Natalizumab in pediatric multiple sclerosis: results of a cohort of 55 cases
    A Ghezzi
    Multiple Sclerosis Study Center, Hospital of Gallarate, Italy
    Mult Scler 19:1106-12. 2013
  7. doi request reprint Adverse events after endovascular treatment of chronic cerebro-spinal venous insufficiency (CCSVI) in patients with multiple sclerosis
    A Ghezzi
    Centro Studi Sclerosi Multipla, Ospedale di Gallarate, Italy
    Mult Scler 19:961-3. 2013
  8. ncbi request reprint Treatment of early-onset multiple sclerosis with intramuscular interferonbeta-1a: long-term results
    A Ghezzi
    Centro Studi Sclerosi Multipla, Ospedale di Gallarate, Via Pastori 4, I 20013, Gallarate, Italy
    Neurol Sci 28:127-32. 2007
  9. doi request reprint Cognitive impairment in pediatric multiple sclerosis
    A Ghezzi
    Centro Studi Sclerosi Multipla, Azienda ospedaliera S Antonio Abate di Gallarate, Gallarate, Italy
    Neurol Sci 31:S215-8. 2010
  10. doi request reprint Recommendations for the management of urinary disorders in multiple sclerosis: a consensus of the Italian Multiple Sclerosis Study Group
    A Ghezzi
    Neurology II Department, Multiple Sclerosis Study Centre, Gallarate Hospital, 21013 Gallarate, Italy
    Neurol Sci 32:1223-31. 2011

Detail Information

Publications46

  1. doi request reprint Chronic cerebro-spinal venous insufficiency (CCSVI) and multiple sclerosis
    A Ghezzi
    Centro Studi Sclerosi Multipla, Ospedale di Gallarate, Coordinator of Multiple Sclerosis Study Group, Italian Society of Neurology, Gallarate, Italy
    Neurol Sci 32:17-21. 2011
    ..It is urgent to perform appropriate epidemiological studies to define the possible relationship between CCSVI and MS...
  2. doi request reprint Current recommendations for multiple sclerosis treatment in pregnancy and puerperium
    Angelo Ghezzi
    UO Neurologia 2 Centro Studi Sclerosi Multipla, Ospedale di Gallarate, Via Pastori 4, 21013 Gallarate, Italy
    Expert Rev Clin Immunol 9:683-91; quiz 692. 2013
    ..However, if their preventive withdrawal exposes patients to a high risk of disease activity, these medications could be continued until proven conception. Little information is available on the effect of natalizumab and fingolimod...
  3. ncbi request reprint Endovascular treatment of CCSVI in patients with multiple sclerosis: clinical outcome of 462 cases
    A Ghezzi
    Centro Studi Sclerosi Multipla, Ospedale di Gallarate, Gallarate, Italy
    Neurol Sci 34:1633-7. 2013
    ..Fifteen severe adverse events were recorded in 3.2 % of cases. Given the risk of severe adverse events and the lack of objective beneficial effects, our findings confirm that at present ET should not be recommended to patients with MS...
  4. pmc Epidural analgesia and cesarean delivery in multiple sclerosis post-partum relapses: the Italian cohort study
    Luisa Pastò
    Department of Neurology, University of Florence, Viale Morgagni 85, 50134, Florence, Italy
    BMC Neurol 12:165. 2012
    ..The objective of this study was to assess the impact of epidural analgesia (EA) and caesarean delivery (CD) on the risk of post-partum relapses and disability in women with MS...
  5. pmc Pregnancy and fetal outcomes after Glatiramer Acetate exposure in patients with multiple sclerosis: a prospective observational multicentric study
    Marta Giannini
    Department of Neurology, University of Florence, Florence, Italy
    BMC Neurol 12:124. 2012
    ....
  6. doi request reprint Natalizumab in pediatric multiple sclerosis: results of a cohort of 55 cases
    A Ghezzi
    Multiple Sclerosis Study Center, Hospital of Gallarate, Italy
    Mult Scler 19:1106-12. 2013
    ..Limited information is available on the use of natalizumab (NA) in pediatric multiple sclerosis (ped-MS) patients...
  7. doi request reprint Adverse events after endovascular treatment of chronic cerebro-spinal venous insufficiency (CCSVI) in patients with multiple sclerosis
    A Ghezzi
    Centro Studi Sclerosi Multipla, Ospedale di Gallarate, Italy
    Mult Scler 19:961-3. 2013
    ..One patient died because of myocardial infarction 10 weeks after ET. The risk of severe AEs related to ET for CCSVI must be carefully considered...
  8. ncbi request reprint Treatment of early-onset multiple sclerosis with intramuscular interferonbeta-1a: long-term results
    A Ghezzi
    Centro Studi Sclerosi Multipla, Ospedale di Gallarate, Via Pastori 4, I 20013, Gallarate, Italy
    Neurol Sci 28:127-32. 2007
    ..IM IFNbeta-1a was effective and well tolerated in these paediatric patients with MS...
  9. doi request reprint Cognitive impairment in pediatric multiple sclerosis
    A Ghezzi
    Centro Studi Sclerosi Multipla, Azienda ospedaliera S Antonio Abate di Gallarate, Gallarate, Italy
    Neurol Sci 31:S215-8. 2010
    ..The frequency and severity of cognitive impairment increase with time. Cognitive impairment has a negative impact on patient's life limiting social, academic and recreational activities...
  10. doi request reprint Recommendations for the management of urinary disorders in multiple sclerosis: a consensus of the Italian Multiple Sclerosis Study Group
    A Ghezzi
    Neurology II Department, Multiple Sclerosis Study Centre, Gallarate Hospital, 21013 Gallarate, Italy
    Neurol Sci 32:1223-31. 2011
    ..A diagnostic-therapeutic algorithm is proposed, that can be applied in Italian clinical centres...
  11. doi request reprint Natalizumab therapy of multiple sclerosis: recommendations of the Multiple Sclerosis Study Group--Italian Neurological Society
    A Ghezzi
    U O Neurologia II, Centro Studi Sclerosi Multipla, Ospedale di Gallarate, Gallarate, Italy
    Neurol Sci 32:351-8. 2011
    ..This article summarizes the MS-SIN Study Group recommendations on the use of NA in MS, with particular reference to the appropriate selection and monitoring of patients as well as to the management of adverse events...
  12. doi request reprint Safety and efficacy of natalizumab in children with multiple sclerosis
    A Ghezzi
    Centro Studi Sclerosi Multipla, Via Pastori 4, Ospedale di Gallarate, Gallarate, Italy
    Neurology 75:912-7. 2010
    ..To describe the effect of natalizumab in the treatment of subjects with active multiple sclerosis (MS) treated before the age of 18 years...
  13. doi request reprint Long-term results of immunomodulatory treatment in children and adolescents with multiple sclerosis: the Italian experience
    Angelo Ghezzi
    Centro Studi Sclerosi Multipla, Ospedale di Gallarate, Via Pastori 4, 20013, Gallarate, Italy
    Neurol Sci 30:193-9. 2009
    ..The frequency of clinical and laboratory adverse events was similar to that observed in adult patients. To conclude, IMAs were effective and well tolerated in paediatric patients with MS...
  14. ncbi request reprint Disease-modifying drugs in childhood-juvenile multiple sclerosis: results of an Italian co-operative study
    A Ghezzi
    Centro Studi Sclerosi Multipla, Ospedale di Gallarate, Gallarate, Italy
    Mult Scler 11:420-4. 2005
    ..The aim of this study was to evaluate the impact of IFNbeta and GA in MS patients treated before 16 years of age...
  15. ncbi request reprint Immunomodulatory treatment of early onset multiple sclerosis: results of an Italian Co-operative Study
    A Ghezzi
    Centro Studi Sclerosi Multipla, Ospedale S Antonio Abate, Via Pastori 4, I 21013, Gallarate, Italy
    Neurol Sci 26:S183-6. 2005
    ..The treatment was generally well tolerated. It reduced the relapse rate and the progression of the disease in most cases...
  16. ncbi request reprint Italian studies on early-onset multiple sclerosis: the present and the future
    A Ghezzi
    Centro Studi Sclerosi Multipla, Ospedale di Gallarate, Via Pastori 4, I 21013 Gallarate, Italy
    Neurol Sci 25:S346-9. 2004
  17. ncbi request reprint Prospective study of multiple sclerosis with early onset
    A Ghezzi
    Centro Studi Sclerosi Multipla, Ospedale di Gallarate, Universita di Milano, Milan, Italy
    Mult Scler 8:115-8. 2002
    ..008). There was a tendency to a worse prognosis in relation to the number of relapses in the first 2 years (p=0.08). The outcome was not influenced by the characteristics of symptoms at onset age and gender...
  18. ncbi request reprint Cranial nerve, brainstem and cerebellar syndromes in the differential diagnosis of multiple sclerosis
    M Zaffaroni
    Multiple Sclerosis Study Center, Department of Neurology, Gallarate Hospital, Italy
    Neurol Sci 22:S74-8. 2001
    ..The main alternative causes of symptoms that may suggest a clinical onset of MS are reviewed here, grouped in principal clinical syndromes, with particular attention to some rare, recently recognised conditions...
  19. ncbi request reprint Longitudinal survey of T-lymphocytes and viral antibodies in MS patients
    D Caputo
    Centro Studi Sclerosi Multipla, Gallarate
    Ital J Neurol Sci . 1987
    ..These results are discussed with special reference to the correlation between OKT8+ lymphocyte percentages and anti-HTLV-1 antibodies, since this last virus has recently been claimed to be of pathogenetic importance in MS...
  20. ncbi request reprint Intensive immunosuppression in multiple sclerosis
    M Zaffaroni
    Centro Studi Sclerosi Multipla, Az Osp S Antonio Abate, Via Pastori 4, I 21013 Gallarate VA, Italy
    Neurol Sci 27:S13-7. 2006
    ..Although immunosuppressants are best effective in induction therapy, their use is limited by toxicity and potential long-term risk...
  21. ncbi request reprint Clinical characteristics of multiple sclerosis with early onset
    A Ghezzi
    Centro Studi Sclerosi Multipla, Ospedale di Gallarate Via Pastori 4, 1 21013 Gallarate, Italy
    Neurol Sci 25:S336-9. 2004
    ..Negative prognostic factors are: a short inter-attack interval, a high relapse rate, a relapsing-progressive course or the shift to the secondary progressive phase, and early accumulation of disability...
  22. ncbi request reprint Neurological manifestations of gastrointestinal disorders, with particular reference to the differential diagnosis of multiple sclerosis
    A Ghezzi
    Centro Studi Sclerosi Multipla, Ospedale di Gallarate, , Gallarate, Varese, Italy
    Neurol Sci 22:S117-22. 2001
    ..Neurological manifestations can be the consequence of vitamin B1, nicotinamide, vitamin B12, vitamin D, or vitamin E deficiency and from nutritional deficiency states following gastric surgery...
  23. ncbi request reprint Devic's neuromyelitis optica and mitochondrial DNA mutation: a case report
    A Ghezzi
    Centro Studi Sclerosi Multipla, Ospedale di Gallarate, Via Pastori 4, I 21013 Gallarate, Italy
    Neurol Sci 25:S380-2. 2004
    ..We describe a case of a young woman with Devic's neuromyelitis optica and 3460 homoplasmic mitochondrial DNA mutation...
  24. ncbi request reprint Adhesion of mononuclear cells from multiple sclerosis patients to cerebral vessels in cryostat sections of normal human brain
    M Zaffaroni
    Centro Studi Sclerosi Multipla, University of Milan, Hospital of Gallarate, Via Pastori 4, 21013 Gallarate, Gallarate, Italy
    Eur J Neurol 6:579-84. 1999
    ..We confirm that PBM from MS patients show an increased potential of binding to cerebral vessels. The frozen-section assay provides a unique tool to study in situ the molecular interactions of leukocytes with brain vascular structures...
  25. ncbi request reprint Differential diagnosis of acute myelopathies
    A Ghezzi
    Multiple Sclerosis Study Center, Department of Neurology, Gallarate Hospital, Italy
    Neurol Sci 22:S60-4. 2001
    ....
  26. ncbi request reprint Effect of glatiramer acetate on MS lesions enhancing at different gadolinium doses
    M Rovaris
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 59:1429-32. 2002
    ..GA is effective in reducing MS activity, independent of the severity of the MRI-detectable inflammatory process...
  27. ncbi request reprint Autoantibodies in multiple sclerosis patients before and during IFN-beta 1b treatment: are they correlated with the occurrence of autoimmune diseases?
    E Verdun
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Torino, Torino, Italy
    J Interferon Cytokine Res 22:245-55. 2002
    ..Our study indicates that IFN-beta treatment is a safe treatment for MS patients, free of risk of autoimmunity and of associated liver or thyroid function alteration...
  28. ncbi request reprint Devic's neuromyelitis optica: clinical features and prognostic factors
    R Bergamaschi
    Neurological Institute C Mondino, Via Ferrata 6, I 27100 Pavia, Italy
    Neurol Sci 25:S364-7. 2004
    ..In summary, relapsing NMO patients tend to have a poor prognosis, requiring more effective immunosuppressive treatments...
  29. doi request reprint Evidence of thalamic gray matter loss in pediatric multiple sclerosis
    S Mesaros
    Neuroimaging Research Unit, Scientific Institute and University Hospital San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neurology 70:1107-12. 2008
    ....
  30. ncbi request reprint MRI activity and neutralising antibody as predictors of response to interferon beta treatment in multiple sclerosis
    L Durelli
    Dipartimento di Scienze Cliniche e Biologiche, Universita di Torino, Ospedale San Luigi Gonzaga, Regione Gonzole, 10, I 10043 Orbassano, Torino, Italy
    J Neurol Neurosurg Psychiatry 79:646-51. 2008
    ..To prospectively validate MRI activity and neutralising anti-interferon antibody (NAb) during the first 6 months of interferon beta treatment as response indicators in multiple sclerosis (MS)...
  31. pmc Extracorporeal photopheresis affects co-stimulatory molecule expression and interleukin-10 production by dendritic cells in graft-versus-host disease patients
    M Di Renzo
    Azienda Ospedaliera Universitaria Senese, University of Siena, Siena, Italy
    Clin Exp Immunol 151:407-13. 2008
    ....
  32. ncbi request reprint Grading cervical cord damage in neuromyelitis optica and MS by diffusion tensor MRI
    B Benedetti
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 67:161-3. 2006
    ..008) and average fractional anisotropy (p = 0.04). There was a correlation between the Expanded Standard Disability Status Scale score and cord average mean diffusivity (r = 0.52, p = 0.02)...
  33. ncbi request reprint Evidence for widespread movement-associated functional MRI changes in patients with PPMS
    M A Rocca
    Neuroimaging Research, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Italy
    Neurology 58:866-72. 2002
    ..Previous work has suggested that functional reorganization of cortical motor areas might have a role in limiting the motor deficits in patients with MS...
  34. ncbi request reprint In vivo assessment of cervical cord damage in MS patients: a longitudinal diffusion tensor MRI study
    F Agosta
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Brain 130:2211-9. 2007
    ..MS cord pathology also seems to be independent of concomitant brain changes, to develop at different rates according to disease phenotype, and to be associated to medium-term disability accrual...
  35. ncbi request reprint Evidence for widespread axonal damage at the earliest clinical stage of multiple sclerosis
    M Filippi
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Brain 126:433-7. 2003
    ..This finding lessens the validity of the current concept that the axonal pathology of multiple sclerosis is the end-stage result of repeated inflammatory events, and argues strongly in favour of early neuroprotective intervention...
  36. ncbi request reprint Axonal injury in early multiple sclerosis is irreversible and independent of the short-term disease evolution
    M Rovaris
    Neuroimaging Research Unit, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 65:1626-30. 2005
    ..To define the nature and the temporal evolution of neuronal/axonal injury in patients at the earliest clinical stage of multiple sclerosis (MS), using whole brain N-acetylaspartate (WBNAA) proton MR spectroscopy (1H-MRS)...
  37. ncbi request reprint Evidence of early cortical atrophy in MS: relevance to white matter changes and disability
    N De Stefano
    Institute of Neurological Sciences, University of Siena, Italy
    Neurology 60:1157-62. 2003
    ....
  38. ncbi request reprint Italian version of the Chicago multiscale depression inventory: translation, adaptation and testing in people with multiple sclerosis
    A Solari
    Laboratory of Epidemiology, C Besta National Neurological Institute, Via Celoria 11, I 20133, Milan, Italy
    Neurol Sci 24:375-83. 2004
    ..The Italian CMDI is characterized by good acceptability, internal consistency, and test-retest reliability. These findings support the use of the CMDI in Italian subjects with MS to screen for and follow depressive symptoms...
  39. ncbi request reprint An MT MRI study of the cervical cord in clinically isolated syndromes suggestive of MS
    M Rovaris
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Neurology 63:584-5. 2004
    ..These findings suggest the absence of intrinsic structural damage of the cervical cord soon after the onset of CIS suggestive of MS, even in those patients with an early evolution to MS...
  40. ncbi request reprint The prevalence of pain in multiple sclerosis: a multicenter cross-sectional study
    C Solaro
    Department of Neurology, P A Micone Hospital, Genova, Italy
    Neurology 63:919-21. 2004
    ..This study underlines the relevance of pain in the clinical history of MS...
  41. ncbi request reprint Multiple sclerosis and celiac disease: is there an increased risk?
    S Salvatore
    Clinica Pediatrica, Universita dell Insubria, Varese, Italy
    Mult Scler 10:711-2. 2004
    ..No patients showed pathological values. Different immune and genetic basis between the two diseases may represent crucial insights to explain our results...
  42. doi request reprint Cognitive impairment and structural brain damage in benign multiple sclerosis
    M Rovaris
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 71:1521-6. 2008
    ..Against this background, we investigated the extent of structural brain damage underlying cognitive dysfunction in BMS, with the ultimate aim to move a first step toward a more reliable definition of this disease phenotype...
  43. doi request reprint Absence of diffuse cervical cord tissue damage in early, non-disabling relapsing-remitting MS: a preliminary study
    M Rovaris
    Neuroimaging Research Unit, San Raffaele Scientific Institute, Milan, Italy
    Mult Scler 14:853-6. 2008
    ..MT MRI-derived measures of cord damage are correlated with the severity of disease-related locomotor disability...
  44. doi request reprint Cognitive and psychosocial features of childhood and juvenile MS
    M P Amato
    Department of Neurology, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    Neurology 70:1891-7. 2008
    ..To assess the impact of multiple sclerosis (MS) on cognitive and psychosocial functioning in childhood and juvenile cases...
  45. ncbi request reprint Subgroups of the BENEFIT study: risk of developing MS and treatment effect of interferon beta-1b
    Chris Polman
    Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    J Neurol 255:480-7. 2008
    ..The BENEFIT study examined interferon beta (IFNB)-1b treatment in patients with clinically isolated syndrome (CIS) and > or = 2 clinically silent brain MRI lesions...
  46. ncbi request reprint MRI quantification of gray and white matter damage in patients with early-onset multiple sclerosis
    P Tortorella
    Neuroimaging Research Unit Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132, Milan, Italy
    J Neurol 253:903-7. 2006
    ..Our objective was to evaluate the presence and extent of tissue damage in the brain normalappearing white matter (NAWM) and gray matter (GM) from a larger population of patients with earlyonset MS...