Valli De Re

Summary

Affiliation: Centro di Riferimento Oncologico
Country: Italy

Publications

  1. doi request reprint Genetic diversity of the KIR/HLA system and outcome of patients with metastatic colorectal cancer treated with chemotherapy
    Valli De Re
    Translational Research, CRO National Cancer Institute, IRCCS, Aviano, Pordenone, Italy
    PLoS ONE 9:e84940. 2014
  2. pmc Identification and characterization of CDH1 germline variants in sporadic gastric cancer patients and in individuals at risk of gastric cancer
    Marica Garziera
    Departement of Translational Research, Centro di Riferimento Oncologico CRO, National Cancer Institute, Aviano, Pordenone, Italy
    PLoS ONE 8:e77035. 2013
  3. doi request reprint The versatile role of gliadin peptides in celiac disease
    Valli De Re
    Clinical and Experimental Pharmacology, Centro di Riferimento Oncologico, IRCCS, National Cancer Institute, Aviano, Pordenone, Italy
    Clin Biochem 46:552-60. 2013
  4. pmc Molecular signature in HCV-positive lymphomas
    Valli De Re
    Unit of Clinical and Experimental Pharmacology, IRCCS, Centro di Riferimento Oncologico, National Cancer Institute, 33081 Aviano, Pordenone, Italy
    Clin Dev Immunol 2012:623465. 2012
  5. ncbi request reprint Protein expression profile of celiac disease patient with aberrant T cell by two-dimensional difference gel electrophoresis
    Valli De Re
    Experimental and Clinical Farmacology Unit, DOMERT Department, Centro di Riferimento Oncologico, IRCCS, National Cancer Institute, Aviano PN, Italy
    Ann N Y Acad Sci 1109:429-40. 2007
  6. doi request reprint Proteomic analyses lead to a better understanding of celiac disease: focus on epitope recognition and autoantibodies
    Valli De Re
    Experimental and Clinical Pharmacology Unit, Molecular Oncology and Translational Medicine, DOMERT, Centro di Riferimento Oncologico, IRCCS National Cancer Institute, Via F Gallini 2, Aviano, PN, Italy
    Dig Dis Sci 55:3041-6. 2010
  7. ncbi request reprint Genetic insights into the disease mechanisms of type II mixed cryoglobulinemia induced by hepatitis C virus
    V De Re
    CRO IRCCS, Aviano National Cancer Institute, Pordenone, Italy
    Dig Liver Dis 39:S65-71. 2007
  8. ncbi request reprint Recent patents relating to HCV molecules like putative targets for therapeutic intervention
    Valli De Re
    Centro di Riferimento Oncologico, IRCCS, National Cancer Institute, Aviano, Pordenone, Italy
    Recent Pat DNA Gene Seq 1:186-94. 2007
  9. doi request reprint HLA DR-DQ combination associated with the increased risk of developing human HCV positive non-Hodgkin's lymphoma is related to the type II mixed cryoglobulinemia
    V De Re
    Centro di Riferimento Oncologico, IRCCS, National Cancer Institute, Aviano, Italy
    Tissue Antigens 75:127-35. 2010
  10. doi request reprint Galectin-10, eosinophils, and celiac disease
    Valli De Re
    Experimental and Clinical Pharmacology Unit, Istituto di Ricovero e Cura a Carattere Scientifico, Aviano, Italy
    Ann N Y Acad Sci 1173:357-64. 2009

Collaborators

Detail Information

Publications48

  1. doi request reprint Genetic diversity of the KIR/HLA system and outcome of patients with metastatic colorectal cancer treated with chemotherapy
    Valli De Re
    Translational Research, CRO National Cancer Institute, IRCCS, Aviano, Pordenone, Italy
    PLoS ONE 9:e84940. 2014
    ....
  2. pmc Identification and characterization of CDH1 germline variants in sporadic gastric cancer patients and in individuals at risk of gastric cancer
    Marica Garziera
    Departement of Translational Research, Centro di Riferimento Oncologico CRO, National Cancer Institute, Aviano, Pordenone, Italy
    PLoS ONE 8:e77035. 2013
    ..To screen and characterize germline variants for E-cadherin (CDH1) in non-hereditary gastric cancer (GC) patients and in subjects at risk of GC...
  3. doi request reprint The versatile role of gliadin peptides in celiac disease
    Valli De Re
    Clinical and Experimental Pharmacology, Centro di Riferimento Oncologico, IRCCS, National Cancer Institute, Aviano, Pordenone, Italy
    Clin Biochem 46:552-60. 2013
    ....
  4. pmc Molecular signature in HCV-positive lymphomas
    Valli De Re
    Unit of Clinical and Experimental Pharmacology, IRCCS, Centro di Riferimento Oncologico, National Cancer Institute, 33081 Aviano, Pordenone, Italy
    Clin Dev Immunol 2012:623465. 2012
    ..Even if recent progress on HCV-B-NHL signature has been made, the precise relationship between HCV and lymphoma development and phenotype signature remain to be clarified...
  5. ncbi request reprint Protein expression profile of celiac disease patient with aberrant T cell by two-dimensional difference gel electrophoresis
    Valli De Re
    Experimental and Clinical Farmacology Unit, DOMERT Department, Centro di Riferimento Oncologico, IRCCS, National Cancer Institute, Aviano PN, Italy
    Ann N Y Acad Sci 1109:429-40. 2007
    ..Results also emphasize the possible association of apolipoprotein with aberrant T cell proliferation...
  6. doi request reprint Proteomic analyses lead to a better understanding of celiac disease: focus on epitope recognition and autoantibodies
    Valli De Re
    Experimental and Clinical Pharmacology Unit, Molecular Oncology and Translational Medicine, DOMERT, Centro di Riferimento Oncologico, IRCCS National Cancer Institute, Via F Gallini 2, Aviano, PN, Italy
    Dig Dis Sci 55:3041-6. 2010
    ..A fast technological development of these methods, along with the combination of classic techniques with proteomics, will lead to new discoveries, which will consent a better understanding of the pathogenesis of CD...
  7. ncbi request reprint Genetic insights into the disease mechanisms of type II mixed cryoglobulinemia induced by hepatitis C virus
    V De Re
    CRO IRCCS, Aviano National Cancer Institute, Pordenone, Italy
    Dig Liver Dis 39:S65-71. 2007
    ..The work was performed in accordance with the principles of the 1983 Declaration of Helsinki. There is no conflict of interest...
  8. ncbi request reprint Recent patents relating to HCV molecules like putative targets for therapeutic intervention
    Valli De Re
    Centro di Riferimento Oncologico, IRCCS, National Cancer Institute, Aviano, Pordenone, Italy
    Recent Pat DNA Gene Seq 1:186-94. 2007
    ....
  9. doi request reprint HLA DR-DQ combination associated with the increased risk of developing human HCV positive non-Hodgkin's lymphoma is related to the type II mixed cryoglobulinemia
    V De Re
    Centro di Riferimento Oncologico, IRCCS, National Cancer Institute, Aviano, Italy
    Tissue Antigens 75:127-35. 2010
    ..519). Thus, cryoglobulinemia clinical manifestation was found to be correlated with the preferential use of HLA DR-DQ combination in HCV-associated NHL. These data provide new insight into HCV-associated lymphoproliferative pathogenesis...
  10. doi request reprint Galectin-10, eosinophils, and celiac disease
    Valli De Re
    Experimental and Clinical Pharmacology Unit, Istituto di Ricovero e Cura a Carattere Scientifico, Aviano, Italy
    Ann N Y Acad Sci 1173:357-64. 2009
    ..Moreover, our data provide insights into alterations associated with CD tissue damage and pathogenesis...
  11. ncbi request reprint Role of the HLA class II: HCV-related disorders
    Valli De Re
    CRO IRCCS, Aviano National Cancer Institute, Pordenone, Italy
    Ann N Y Acad Sci 1107:308-18. 2007
    ....
  12. doi request reprint HCV inhibits antigen processing and presentation and induces oxidative stress response in gastric mucosa
    Valli De Re
    Experimental and Clinical Pharmacology, CRO Centro di Riferimento Oncologico, IRCCS National Cancer Institute, Aviano, Italy
    Proteomics Clin Appl 2:1290-9. 2008
    ..Both these processes facilitate immune escape and cell survival and probably contribute to HCV chronicization...
  13. pmc Proteins specifically hyperexpressed in a coeliac disease patient with aberrant T cells
    V De Re
    Farmacologia Sperimentale e Clinica, Centro di Riferimento Oncologico, Aviano PN, Italy
    Clin Exp Immunol 148:402-9. 2007
    ..The results also emphasize the possible association of apolipoprotein with aberrant T cell proliferation...
  14. ncbi request reprint Hepatitis C virus-related hepatocellular carcinoma and B-cell lymphoma patients show a different profile of major histocompatibility complex class II alleles
    V De Re
    Division of Experimental Oncology Centro di Riferimento Oncologico, IRCCS National Cancer Institute, Aviano, Italy
    Hum Immunol 65:1397-404. 2004
    ....
  15. doi request reprint Clonal CD27+ CD19+ B cell expansion through inhibition of FC gammaIIR in HCV(+) cryoglobulinemic patients
    Valli De Re
    Experimental and Clinical Pharmacology Unit, DOMERT, Molecular Oncology and Translational Research Department, Centro di Riferimento Oncologico, IRCCS, National Cancer Institute, Aviano PN, Italy
    Ann N Y Acad Sci 1173:326-33. 2009
    ..This takes the brake off RF(+)CD27(+) B cell proliferation and promotes their selective accumulation, which is otherwise prevented by increased apoptosis susceptibility in persistent HCV infection without II-MC...
  16. ncbi request reprint Type II mixed cryoglobulinaemia as an oligo rather than a mono B-cell disorder: evidence from GeneScan and MALDI-TOF analyses
    V De Re
    Division of Experimental Oncology I, Centro di Riferimento Oncologico Via Pedemontana Occidentale 12, 33081 Aviano PN, Italy
    Rheumatology (Oxford) 45:685-93. 2006
    ..To identify and characterize rheumatoid factor (RF)-producing B-cells and cryoprecipitate immunoglobulin (Ig) M in hepatitis C virus (HCV)-positive patients...
  17. ncbi request reprint HCV-NS3 and IgG-Fc crossreactive IgM in patients with type II mixed cryoglobulinemia and B-cell clonal proliferations
    V De Re
    Division of Experimental Oncology I, Centro di Riferimento Oncologico, IRCCS National Cancer Institute, Aviano, Pordenone, Italy
    Leukemia 20:1145-54. 2006
    ..We suggest that engagement of specific BCRs by NS3 (or NS3-immunocomplex) antigen could explain the prevalence of IgM cryoglobulins in these patients...
  18. ncbi request reprint KIR molecules: recent patents of interest for the diagnosis and treatment of several autoimmune diseases, chronic inflammation, and B-cell malignancies
    Valli De Re
    Laboratory of Experimental and Clinical Pharmacology, Department of Molecular Oncology and Translational Medicine DOMERT, Centro di Riferimento Oncologico, IRCCS, National Cancer Institute, Via F Gallini, 2, 33081 Aviano PN, Italy
    Recent Pat DNA Gene Seq 5:169-74. 2011
    ....
  19. doi request reprint Characterization of antibodies directed against the immunoglobulin light kappa chain variable chain region (VK) of hepatitis C virus-related type-II mixed cryoglobulinemia and B-cell proliferations
    Valli De Re
    Experimental and Clinical Pharmacology Unit, Dipartimento di Oncologia Molecolare e Ricerca Traslazionale, Centro di Riferimento Oncologico, IRCCS, National Cancer Institute, Franco Gallini, 2, 33081 Aviano PN, Italy
    Ann N Y Acad Sci 1173:152-60. 2009
    ....
  20. pmc MTHFR polymorphisms in gastric cancer and in first-degree relatives of patients with gastric cancer
    Valli De Re
    Experimental and Clinical Pharmacology, Centro di Riferimento Oncologico, IRCCS, National Cancer Institute, Aviano, Italy
    Tumour Biol 31:23-32. 2010
    ..In conclusion, overall findings support the hypothesis that folate plays a role in GC risk. GC-relatives evidence a similar 677TT frequency to that found in the general population...
  21. pmc Two-dimensional gel proteome reference map of human small intestine
    Maria Paola Simula
    Experimental and Clinical Pharmacology, CRO Centro di Riferimento Oncologico, IRCCS National Cancer Institute, Via F, Gallini 2, 33081 Aviano, PN, Italy
    Proteome Sci 7:10. 2009
    ..Spots identifications, reported in a database, will be helpful to identify the variability in protein expression levels, in isoforms expression, or in post-translational modifications associated to pathology or to a therapy...
  22. pmc Immune signatures in human PBMCs of idiotypic vaccine for HCV-related lymphoproliferative disorders
    Luigi Buonaguro
    Lab, of Molecular Biology and Viral Oncogenesis and AIDS Reference Center, Istituto Nazionale Tumori Fond, G, Pascale, Naples, Italy
    J Transl Med 8:18. 2010
    ..This objective has been pursued by implementing high-throughput technologies such as multiparameter flow cytometry and multiplex analysis of cytokines and chemokines...
  23. doi request reprint Undifferentiated nasopharyngeal carcinoma from a nonendemic area: protective role of HLA allele products presenting conserved EBV epitopes
    Elisa Pasini
    Cancer Bioimmunotherapy Unit, IRCCS National Cancer Institute, Aviano PN, Italy
    Int J Cancer 125:1358-64. 2009
    ..These results have practical implications for the immunotherapy of UNPC...
  24. ncbi request reprint Aggressive forms of non-Hodgkin's lymphoma in two patients bearing coinfection of Epstein-Barr and hepatitis C viruses
    Massimo Libra
    Division of Experimental Oncology 1, Centro di Riferimento Oncologico Aviano, Istituto Nazionale Tumori, IRCCS, Via Pedemontana Occidentale 12, I 33081 Aviano, PN, Italy
    Int J Oncol 26:945-50. 2005
    ..Together, these data suggest that EBV infection may cooperate with HCV infection during progression of B-cell NHL in immunocompetent individuals. Such an interaction may accelerate the course of disease in B-cell NHL patients...
  25. doi request reprint KIR/HLA combination associated with the risk of complications in celiac disease
    Laura Caggiari
    Experimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico, IRCCS, National Cancer Institute, Aviano Italy
    Int J Biol Markers 26:221-8. 2011
    ..These results suggest that a KIR haplotype and HLA ligands may be involved in the susceptibility to important clinical CD complications such as tumors or refractoriness as a result of a gluten-free diet...
  26. ncbi request reprint Extrasalivary lymphoma development in Sjögren's syndrome: clonal evolution from parotid gland lymphoproliferation and role of local triggering
    Daniela Gasparotto
    Centro di Riferimento Oncologico, Istituto di Ricovero e Cura a Carattere Scientifico, Aviano, Italy
    Arthritis Rheum 48:3181-6. 2003
    ....
  27. ncbi request reprint Salivary gland B cell lymphoproliferative disorders in Sjögren's syndrome present a restricted use of antigen receptor gene segments similar to those used by hepatitis C virus-associated non-Hodgkins's lymphomas
    Valli De Re
    Division of Experimental Oncology 1, Centro di Riferimento Oncologico, IRCS, Aviano, Italy
    Eur J Immunol 32:903-10. 2002
    ....
  28. pmc PPAR signaling pathway and cancer-related proteins are involved in celiac disease-associated tissue damage
    Maria Paola Simula
    Experimental and Clinical Pharmacology Unit, CRO Centro diRiferimento Oncologico, IRCCS National Cancer Institute, Aviano PN, Italy
    Mol Med 16:199-209. 2010
    ....
  29. ncbi request reprint Improving detection of celiac disease patients: a prospective study in iron-deficient blood donors without anemia in north Italy
    Renato Cannizzaro
    aDepartment of Gastroenterology bTranslational Research Department, Stem Cell Unit cDepartment of Translational Research, Faculty of Bioproteomic dDepartment of Pathology, Centro di Riferimento Oncologico, National Cancer Institute, IRCCS, Aviano PN, Italy
    Eur J Gastroenterol Hepatol 26:721-4. 2014
    ..To evaluate the prevalence of celiac disease in asymptomatic iron-deficient blood donors without anemia...
  30. doi request reprint IGKV3 proteins as candidate "off-the-shelf" vaccines for kappa-light chain-restricted B-cell non-Hodgkin lymphomas
    Debora Martorelli
    Cancer Bio Immunotherapy Unit, IRCCS National Cancer Institute, Aviano, Italy
    Clin Cancer Res 18:4080-91. 2012
    ..An increasing set of B-cell non-Hodgkin lymphomas (B-NHL) show a biased usage of IGKV3-20 and IGKV3-15 immunoglobulin genes, a feature that could be exploited for the development of ready-to-use, broadly applicable cancer vaccines...
  31. ncbi request reprint Identification of novel chimpanzee MHC class I and II alleles using an improved sequence-based typing strategy
    Laura Caggiari
    Division of Experimental Oncology I, Department of Pre Clinical and Epidemiological Research, Centro di Riferimento Oncologico, IRCCS National Cancer Institute, Aviano PN Italy
    Hum Immunol 67:63-72. 2006
    ....
  32. doi request reprint A novel CDH1 germline missense mutation in a sporadic gastric cancer patient in north-east of Italy
    Marica Garziera
    Experimental and Clinical Pharmacology Unit, Department of Molecular Oncology and Translational Medicine, DOMERT, IRCCS, National Cancer Institute, Centro di Riferimento Oncologico, Via F Gallini, 2, 33081, Aviano, PN, Italy
    Clin Exp Med 13:149-57. 2013
    ..In conclusion, the pathogenicity of this mutation is unlikely; probably we found a new germline CDH1 missense mutation with potential impact, however, of uncertain significance...
  33. ncbi request reprint Analysis of aberrant somatic hypermutation (SHM) in non-Hodgkin's lymphomas of patients with chronic HCV infection
    Massimo Libra
    Experimental Oncology 1, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, Istituto di Ricovero e Cura a Carattere Scientifico, Aviano, Italy
    J Pathol 206:87-91. 2005
    ..This indicates that, unlike B-cell lymphomas from HCV-negative patients, aberrant SHM may not contribute significantly to malignant transformation in HCV-associated B-cell lymphomas...
  34. ncbi request reprint HCV-related immunocytoma and type II mixed cryoglobulinemia-associated autoantigens
    Maria Paola Simula
    Farmacologia Sperimentale e Clinica DOMERT, Centro di Riferimento Oncologico, IRCCS V F Gallini, 2 33081 Aviano, Pordenone, Italy
    Ann N Y Acad Sci 1110:121-30. 2007
    ..The characterization of antigenic specificity of this antibody may be useful to idengify antigens that can stimulate B cell proliferation in HCV-infected individuals...
  35. doi request reprint Sorafenib for the treatment of unresectable hepatocellular carcinoma in HIV-positive patients
    Massimiliano Berretta
    Department of Medical Oncology, National Cancer Institute IRCCS, Aviano PN, Italy
    Anticancer Drugs 24:212-8. 2013
    ..9%). Most drug-related side effects were low grade and manageable. This retrospective study shows favorable survival data among HIV-u-HCC patients treated with sorafenib together with a reasonable safety profile...
  36. doi request reprint Spontaneous T cell responses to Epstein-Barr virus-encoded BARF1 protein and derived peptides in patients with nasopharyngeal carcinoma: bases for improved immunotherapy
    Debora Martorelli
    Cancer Bioimmunotherapy Unit, Centro di Riferimento Oncologico, IRCCS National Cancer Institute, Aviano, PN, Italy
    Int J Cancer 123:1100-7. 2008
    ....
  37. ncbi request reprint Hepatitis C virus, B-cell proliferation and lymphomas
    Daniela Gasparotto
    Division of Experimental Oncology, Centro di Riferimento Oncologico, Aviano PN, Italy
    Leuk Lymphoma 43:747-51. 2002
    ..The restricted gene repertoire used to assemble the B-cell receptor observed in HCV-associated B-cell NHLs could have important implications as an antigenic target in anti-tumor immunologic therapies...
  38. ncbi request reprint Second primary lymphoma or recurrence: a dilemma solved by VDJ rearrangement analysis
    Massimo Libra
    Division of Experimental Oncology 1, Centro di Riferimento Oncologico, Aviano, Pordenone, Italy
    Leuk Lymphoma 45:1539-43. 2004
    ..Furthermore, this technique has the potential to improve treatment of lymphoma patients because management of recurrent lymphomas differs from that of new lymphomas...
  39. doi request reprint Differential proteomics of Helicobacter pylori associated with autoimmune atrophic gastritis
    Ombretta Repetto
    Facility of Bio Proteomics, Centro di Riferimento Oncologico CRO, Aviano National Cancer Institute, Aviano, Italy
    Mol Med 20:57-71. 2014
    ..Other comparative studies by two-dimensional maps integrated with functional genomics of candidate proteins will undoubtedly contribute to better decipher the biology of AAG-associated HP strains. ..
  40. doi request reprint Recent prognostic factors in diffuse large B-cell lymphoma indicate NF-kappaB pathway as a target for new therapeutic strategies
    Alessandro Pavan
    Department of Experimental and Clinical Pharmacology, Centro di Riferimento Oncologico, IRCCS, National Cancer Institute, Aviano, Italy
    Leuk Lymphoma 49:2048-58. 2008
    ..In this review, the NF-kappaB pathway is suggested as a target for new chemotherapy strategies based on the association of CHOP with molecules more effective than rituximab in this pathway inhibition...
  41. pmc Latent membrane protein 1 deletion mutants accumulate in reed-sternberg cells of human immunodeficiency virus-related Hodgkin's lymphoma
    Massimo Guidoboni
    Immunovirology and Biotherapy Unit, Department of Pre Clinical and Epidemiological Research, Centro di Riferimento Oncologico, IRCCS, National Cancer Institute, Via Pedemontana Occidentale 12, 33081 Aviano PN Italy
    J Virol 79:2643-9. 2005
    ....
  42. pmc Endomicroscopy and cancer: a new approach to the visualization of neoangiogenesis
    Renato Cannizzaro
    Department of Gastroenterology, National Cancer Institute, IRCCS, Via F Gallini 2, 33081 Aviano, Italy
    Gastroenterol Res Pract 2012:537170. 2012
    ....
  43. doi request reprint Human immunodeficiency virus-associated precursor T-lymphoblastic leukemia/lymphoblastic lymphoma: report of a case and review of the literature
    Debora Lorenzon
    Servizio di Onco Ematologia Clinico Sperimentale, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, IRCCS, 33081 Aviano, Italy
    Hum Pathol 40:1045-9. 2009
    ..Only 4 cases of human immunodeficiency virus-associated T-lymphoblastic leukemia/lymphoblastic lymphoma are reported in the current medical literature...
  44. doi request reprint 2-D gel electrophoresis: constructing 2D-gel proteome reference maps
    Maria Paola Simula
    Experimental and Clinical Pharmacology Unit, CRO Centro di Riferimento Oncologico, IRCCS National Cancer Institute, Via F Gallini 2, Aviano PN 33081, Italy
    Methods Mol Biol 815:163-73. 2012
    ..The protocol described in this chapter is based on the 2D-DIGE technology and has been applied to obtain the first 2-DE reference map of the human small intestine...
  45. doi request reprint Hepatitis C virus-induced oxidative stress and mitochondrial dysfunction: a focus on recent advances in proteomics
    Maria Paola Simula
    Experimental and Clinical Pharmacology Unit, CRO Centro di Riferimento Oncologico, IRCCS National Cancer Institute, Aviano PN, Italy
    Proteomics Clin Appl 4:782-93. 2010
    ..This review summarizes current knowledge regarding mechanisms of HCV-induced oxidative stress with its long-term effects in the context of HCV-related diseases, and includes a discussion of recent contributions from proteomics studies...
  46. ncbi request reprint Identification of proteins associated to multi-drug resistance in LoVo human colon cancer cells
    Michele Visentin
    Experimental and Clinical Pharmacology Unit, CRO Centro di Riferimento Oncologico, IRCCS National Cancer Institute, 33081 Aviano PN, Italy
    Int J Oncol 34:1281-9. 2009
    ..In conclusion, the proteomic approach indicates that multiple mechanisms are simultaneously involved in MDR. These might be useful in the search for new forms of interventional therapeutic approaches for MDR reversal...
  47. ncbi request reprint Impact of Immunogenetic IL28B Polymorphism on Natural Outcome of HCV Infection
    Valli De Re
    Bio Proteomics Facility, Department of Translational Research, CRO, National Cancer Institute, 33081 Aviano, Italy
    Biomed Res Int 2014:710642. 2014
    ..Study results confirmed the model of persistent HCV infection as a risk factor for the pathogenesis of both liver and lymphoproliferative disorders. ..