A Carbone

Summary

Affiliation: Centro di Riferimento Oncologico
Country: Italy

Publications

  1. ncbi request reprint Diffuse large B cell lymphoma: using pathologic and molecular biomarkers to define subgroups for novel therapy
    Antonino Carbone
    Department of Pathology, Centro di Riferimento Oncologico CRO Aviano, Istituto Nazionale Tumori, IRCCS, Via F Gallini 2, 33081, Aviano, Italy
    Ann Hematol 93:1263-77. 2014
  2. ncbi request reprint The role of inflammation in lymphoma
    Antonino Carbone
    Department of Pathology, Centro di Riferimento Oncologico Aviano, Istituto Nazionale Tumori, IRCCS, Via Franco Gallini, 2, 33081, Aviano, Italy
    Adv Exp Med Biol 816:315-33. 2014
  3. pmc A different immunologic profile characterizes patients with HER-2-overexpressing and HER-2-negative locally advanced breast cancer: implications for immune-based therapies
    Elena Muraro
    Cancer Bio Immunotherapy Unit, Centro di Riferimento Oncologico, IRCCS National Cancer Institute, Via Franco Gallini 2, Aviano PN, 33081, Italy
    Breast Cancer Res 13:R117. 2011
  4. doi request reprint "Intrafollicular neoplasia" of nodular lymphocyte predominant Hodgkin lymphoma: description of a hypothetic early step of the disease
    Antonino Carbone
    Division of Pathology, Centro di Riferimento Oncologico Aviano, Istituto Nazionale Tumori, IRCCS, 33081 Aviano, Italy
    Hum Pathol 43:619-28. 2012
  5. doi request reprint In situ follicular lymphoma associated with nonlymphoid malignancies
    Antonino Carbone
    Division of Pathology, Centro di Riferimento Oncologico Aviano, Istituto Nazionale Tumori, IRCCS, Aviano, Italy
    Leuk Lymphoma 53:603-8. 2012
  6. doi request reprint In situ follicular lymphoma: pathologic characteristics and diagnostic features
    Antonino Carbone
    Division of Pathology, Centro di Riferimento Oncologico Aviano, Istituto Nazionale Tumori, IRCCS, Aviano, Italy
    Hematol Oncol 30:1-7. 2012
  7. pmc Epstein-Barr virus infection and chronic lymphocytic leukemia: a possible progression factor?
    Riccardo Dolcetti
    Cancer Bio Immunotherapy Unit, CRO IRCCS, National Cancer Institute, Via Franco Gallini 2, 33081 Aviano, Italy
    Infect Agent Cancer 5:22. 2010
  8. pmc Drug sensitivity patterns of HHV8 carrying body cavity lymphoma cell lines
    Rita Otvos
    Department of Microbiology, Tumor and Cell Biology MTC and Center for Integrative Recognition in the Immune System IRIS, Karolinska Institute, Box 280 SE 17177 Stockholm, Sweden
    BMC Cancer 11:441. 2011
  9. doi request reprint In situ follicular lymphoma associated with overt B- or T-cell lymphomas in the same lymph node
    Antonino Carbone
    Division of Pathology, Centro di Riferimento Oncologico Aviano, Istituto Nazionale Tumori IRCCS, Aviano, Italy
    Am J Hematol 86:E66-70. 2011
  10. ncbi request reprint New biotechnologies: spin-off on health and society
    A Carbone
    Division of Pathology, Istituto Nazionale Tumori, IRCCS, Aviano PN, Italy
    Int J Biol Markers 17:1-4. 2002

Detail Information

Publications136 found, 100 shown here

  1. ncbi request reprint Diffuse large B cell lymphoma: using pathologic and molecular biomarkers to define subgroups for novel therapy
    Antonino Carbone
    Department of Pathology, Centro di Riferimento Oncologico CRO Aviano, Istituto Nazionale Tumori, IRCCS, Via F Gallini 2, 33081, Aviano, Italy
    Ann Hematol 93:1263-77. 2014
    ..Immunohistochemistry for detecting the expression of these biomarkers is a practical technique that could provide a rational for clinical trial design. ..
  2. ncbi request reprint The role of inflammation in lymphoma
    Antonino Carbone
    Department of Pathology, Centro di Riferimento Oncologico Aviano, Istituto Nazionale Tumori, IRCCS, Via Franco Gallini, 2, 33081, Aviano, Italy
    Adv Exp Med Biol 816:315-33. 2014
    ....
  3. pmc A different immunologic profile characterizes patients with HER-2-overexpressing and HER-2-negative locally advanced breast cancer: implications for immune-based therapies
    Elena Muraro
    Cancer Bio Immunotherapy Unit, Centro di Riferimento Oncologico, IRCCS National Cancer Institute, Via Franco Gallini 2, Aviano PN, 33081, Italy
    Breast Cancer Res 13:R117. 2011
    ..On these grounds, a careful analysis of basal immune profile may be capital to dissect the heterogeneity of clinical responses to these drugs in patients with locally advanced breast cancer undergoing neoadjuvant chemotherapy...
  4. doi request reprint "Intrafollicular neoplasia" of nodular lymphocyte predominant Hodgkin lymphoma: description of a hypothetic early step of the disease
    Antonino Carbone
    Division of Pathology, Centro di Riferimento Oncologico Aviano, Istituto Nazionale Tumori, IRCCS, 33081 Aviano, Italy
    Hum Pathol 43:619-28. 2012
    ..An appropriate immunohistochemical characterization for diagnosis should include lymphocyte predominant (BCL6 and CD20) and microenvironmental (CD23, immunoglobulin D, and PD1) cell markers...
  5. doi request reprint In situ follicular lymphoma associated with nonlymphoid malignancies
    Antonino Carbone
    Division of Pathology, Centro di Riferimento Oncologico Aviano, Istituto Nazionale Tumori, IRCCS, Aviano, Italy
    Leuk Lymphoma 53:603-8. 2012
    ..include: (1) how to approach these patients who have a risk of progression to overt lymphoma; (2) is the association of in situ FL with concurrent nonlymphoid neoplasia incidental, related to immunosuppression or to previous treatment?..
  6. doi request reprint In situ follicular lymphoma: pathologic characteristics and diagnostic features
    Antonino Carbone
    Division of Pathology, Centro di Riferimento Oncologico Aviano, Istituto Nazionale Tumori, IRCCS, Aviano, Italy
    Hematol Oncol 30:1-7. 2012
    ..Other open questions remain on the frequency with which in situ FLs occur and the frequency of concomitant systemic disease...
  7. pmc Epstein-Barr virus infection and chronic lymphocytic leukemia: a possible progression factor?
    Riccardo Dolcetti
    Cancer Bio Immunotherapy Unit, CRO IRCCS, National Cancer Institute, Via Franco Gallini 2, 33081 Aviano, Italy
    Infect Agent Cancer 5:22. 2010
    ..We herein review available data suggesting a possible role of EBV as a direct or micro-environmental progression factor in a subset of CLL...
  8. pmc Drug sensitivity patterns of HHV8 carrying body cavity lymphoma cell lines
    Rita Otvos
    Department of Microbiology, Tumor and Cell Biology MTC and Center for Integrative Recognition in the Immune System IRIS, Karolinska Institute, Box 280 SE 17177 Stockholm, Sweden
    BMC Cancer 11:441. 2011
    ....
  9. doi request reprint In situ follicular lymphoma associated with overt B- or T-cell lymphomas in the same lymph node
    Antonino Carbone
    Division of Pathology, Centro di Riferimento Oncologico Aviano, Istituto Nazionale Tumori IRCCS, Aviano, Italy
    Am J Hematol 86:E66-70. 2011
    ..In conclusion,the association of in situ FL with PTCL expands the spectrum of lymphoproliferations that may coexist with in situ FL and suggests that in situ FL may not behave like a simple precursor for overt FL...
  10. ncbi request reprint New biotechnologies: spin-off on health and society
    A Carbone
    Division of Pathology, Istituto Nazionale Tumori, IRCCS, Aviano PN, Italy
    Int J Biol Markers 17:1-4. 2002
    ..Comprehensive views and careful considerations are therefore needed in order that this new biology may have a positive impact on health, being respectful of the social and ethical principles of human beings...
  11. ncbi request reprint Genetic pathways and histogenetic models of AIDS-related lymphomas
    A Carbone
    Division of Pathology, Centro di Riferimento Oncologico, IRCCS, Istituto Nazionale Tumori, Via Pedemontana Occidentale, I 33081, Aviano, Italy
    Eur J Cancer 37:1270-5. 2001
    ....
  12. doi request reprint Does "in situ lymphoma" occur as a distinct step in the development of nodular lymphocyte-predominant Hodgkin lymphoma?
    Antonino Carbone
    Division of Pathology, Oncology Referral Center Aviano, National Cancer Institute, Aviano, Italy
    Cancer 118:15-6. 2012
    ..Like "in situ FL," this is likely to be an in situ step that potentially leads to overt lymphoma...
  13. doi request reprint Classical Hodgkin's lymphoma arising in different host's conditions: pathobiology parameters, therapeutic options, and outcome
    Antonino Carbone
    Division of Pathology, Centro di Riferimento Oncologico Aviano, Istituto Nazionale Tumori, Aviano, Italy
    Am J Hematol 86:170-9. 2011
    ..Refractory CHL, a clinical condition that may occur throughout the entire spectrum of CHL, is discussed separately...
  14. ncbi request reprint Genomics and proteomics meet diagnostic hematopathology
    A Carbone
    Division of Pathology, Istituto Nazionale Tumori, IRCCS, Aviano PN, Italy
    Int J Biol Markers 17:71-2. 2002
  15. ncbi request reprint Expression pattern of MUM1/IRF4 in the spectrum of pathology of Hodgkin's disease
    Antonino Carbone
    Division of Pathology, Centro di Riferimento Oncologico, IRCCS, Istituto Nazionale Tumori, via Pedemontali Occidentale, Aviano I 33081, Italy
    Br J Haematol 117:366-72. 2002
    ....
  16. ncbi request reprint Acquired immunodeficiency syndrome-related cancer. A study model for the mechanisms contributing to the genesis of cancer
    A Carbone
    Division of Pathology and Scientific Direction, Centro di Riferimento Oncologico, IRCCS, Istituto Nazionale Tumori, Via Pedemontana Occidentale, I 33081, Aviano, Italy
    Eur J Cancer 37:1184-7. 2001
    ....
  17. doi request reprint How I treat: diagnosing and managing "in situ" lymphoma
    Antonino Carbone
    Division of Pathology, Centro di Riferimento Oncologico Aviano, Istituto Nazionale Tumori, Istituto di Ricovero e Cura a Carattere Scientifico, Aviano, Italy
    Blood 117:3954-60. 2011
    ..For patients with concomitant overt lymphoma, staging and treatment procedures must be done according to malignant counterpart...
  18. pmc Kaposi's sarcoma-associated herpesvirus/human herpesvirus type 8-positive solid lymphomas: a tissue-based variant of primary effusion lymphoma
    Antonino Carbone
    Division of Pathology, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, IRCCS, Via Pedemontana Occidentale, Aviano I 33081, Italy
    J Mol Diagn 7:17-27. 2005
    ....
  19. ncbi request reprint Expression status of BCL-6 and syndecan-1 identifies distinct histogenetic subtypes of Hodgkin's disease
    A Carbone
    Division of Pathology, Centro di Riferimento Oncologico, IRCCS, Istituto Nazionale Tumori, Aviano, Italy
    Blood 92:2220-8. 1998
    ..These data indicate that tumor cells of NLPHD uniformly display a GC B-cell phenotype, whereas the phenotype of tumor cells of CHD appears to be modulated by the surrounding cellular background, particularly CD40L+ reactive T cells...
  20. ncbi request reprint Human immunodeficiency virus-associated Hodgkin's disease derives from post-germinal center B cells
    A Carbone
    Division of Pathology and the AIDS Program, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Aviano, Italy
    Blood 93:2319-26. 1999
    ..Conversely, RS cells of virtually all HIV-HD express the EBV-encoded latent membrane protein 1 (LMP1), which, being functionally homologous to CD40, may contribute, at least in part, to the modulation of the HIV-HD phenotype...
  21. ncbi request reprint Characteristics of EBV-infected cells in HIV-related lymphadenopathy: implications for the pathogenesis of EBV-associated and EBV-unrelated lymphomas of HIV-seropositive individuals
    R Dolcetti
    Division of Experimental Oncology 1, INRCCS, Aviano PN, Italy
    Int J Cancer 63:652-9. 1995
    ....
  22. ncbi request reprint Reed-Sternberg cells of classical Hodgkin's disease react with the plasma cell-specific monoclonal antibody B-B4 and express human syndecan-1
    A Carbone
    Division of Pathology, Centro di Riferimento Oncologico, Istituto Nazionale di Ricovero e Cura a Carattere Scientifico, Aviano, Italy
    Blood 89:3787-94. 1997
    ....
  23. doi request reprint Plasma HHV-8 viral load in HHV-8-related lymphoproliferative disorders associated with HIV infection
    C Simonelli
    Division of Medical Oncology A, National Cancer Institute, Aviano, Italy
    J Med Virol 81:888-96. 2009
    ..Multivariate analysis confirmed the diagnosis of lymphoma as an independent predictor of shorter survival...
  24. ncbi request reprint The relevance of VDJ PCR protocols in detecting B-cell clonal expansion in lymphomas and other lymphoproliferative disorders
    V De Re
    Division of Experimental Oncology I, Centro di Riferimento Oncologico, Aviano, Italy
    Tumori 81:405-9. 1995
    ....
  25. ncbi request reprint Can Reed-Sternberg cells of classic Hodgkin's disease be considered B-cells?
    A Carbone
    Division of Pathology, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, Aviano, 33081, Italy
    Adv Clin Path 3:3-9. 1999
    ..This review deals with histological features of HD and summarizes recent results from molecular and immunohistochemical studies focusing on the origin and the stage of differentiation of RS cells...
  26. ncbi request reprint Establishment of HHV-8-positive and HHV-8-negative lymphoma cell lines from primary lymphomatous effusions
    A Carbone
    Division of Pathology, Centro di Riferimento Oncologico, Istituto Nazionale di Ricovero e Cura a Carattere Scientifico, Aviano, Italy
    Int J Cancer 73:562-9. 1997
    ..CRO-AP/1 and CRO-AP/2 may be valuable for the biologic characterization of primary lymphomatous effusions, particularly since the number of available cell lines derived from such lymphomatous effusions is extremely limited...
  27. ncbi request reprint Immunoglobulin and T cell receptor gene rearrangements and in situ immunophenotyping in lymphoproliferative disorders
    A Carbone
    Division of Pathology, Centro di Riferimento Oncologico, Aviano, Italy
    Virchows Arch A Pathol Anat Histopathol 414:223-30. 1989
    ..The significance of clonal B cell expansions found in two AIDS-related lymphadenopathies should be interpreted with caution...
  28. pmc Proliferation in HHV-8-positive primary effusion lymphomas is associated with expression of HHV-8 cyclin but independent of p27(kip1)
    A Carbone
    Division of Pathology, Centro di Riferimento Oncologico, Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale Tumori, Aviano, Italy
    Am J Pathol 156:1209-15. 2000
    ..The fact that HHV-8 v-cyclin is resistant to p27(Kip1)-modulated inhibition, whereas cellular cyclin D1 is sensitive, may explain, at least in part, the co-existence of p27(Kip1) expression and high proliferative index observed in PEL...
  29. ncbi request reprint Combination chemotherapy specifically devised for elderly patients with unfavorable non-Hodgkin's lymphoma
    V Zagonel
    Division of Medical Oncology, Pathology, Centro di Riferimento Oncologico, Aviano, Italy
    Cancer Invest 8:577-82. 1990
    ..We suggest that a combination regimen E + P, suitable for oral administration, may be safely employed in elderly patients with unfavorable NHL...
  30. ncbi request reprint Persistent generalized lymphadenopathy syndrome vs "AIDS"--unrelated malignant lymphoma: comparison of presenting clinical and laboratory findings in 88 patients. AIDS and Related Syndromes Study Group
    U Tirelli
    Division of Medical Oncology, Centro di Riferimento Oncologico, Aviano, Italy
    Tumori 75:222-5. 1989
    ..If not already performed, HIV antibody detection should be carried out in this setting...
  31. ncbi request reprint Human herpesvirus 6 in human immunodeficiency virus-infected individuals: association with early histologic phases of lymphadenopathy syndrome but not with malignant lymphoproliferative disorders
    R Dolcetti
    Department of Experimental Oncology, INRCCS, Aviano PN, Italy
    J Med Virol 48:344-53. 1996
    ....
  32. ncbi request reprint Early gastric cancer: diagnosis, surgical treatment and follow-up of 45 cases
    R Sigon
    Division of Surgical Oncology, University of Modena Centro di Riferimento Oncologico, IRCCS, Aviano, Italy
    Tumori 84:547-51. 1998
    ..The present study, based on 45 EGCs, is aimed at a critical evaluation of the diagnostic procedures and surgical options...
  33. ncbi request reprint A prospective study of a new combination chemotherapy regimen in patients older than 70 years with unfavorable non-Hodgkin's lymphoma
    U Tirelli
    Division of Medical Oncology, Centro di Riferimento Oncologico, INRCCS, Aviano, Italy
    J Clin Oncol 10:228-36. 1992
    ..A prospective trial with a new combination of etoposide, mitoxantrone, and prednimustine (VMP), specifically devised for elderly patients with non-Hodgkin's lymphoma (NHL), was undertaken...
  34. doi request reprint Functional coexpression of Interleukin (IL)-7 and its receptor (IL-7R) on Hodgkin and Reed-Sternberg cells: Involvement of IL-7 in tumor cell growth and microenvironmental interactions of Hodgkin's lymphoma
    Lara Cattaruzza
    Centro di Riferimento Oncologico, IRCCS National Cancer Institute, Aviano, PN, Italy
    Int J Cancer 125:1092-101. 2009
    ....
  35. ncbi request reprint Expression of MUM1/IRF4 selectively clusters with primary effusion lymphoma among lymphomatous effusions: implications for disease histogenesis and pathogenesis
    A Carbone
    Division of Pathology, Centro di Riferimento Oncologico, IRCCS, Istituto Nazionale Tumori, Aviano, Italy
    Br J Haematol 111:247-57. 2000
    ..Finally, MUM1/IRF4 may interact with HHV-8/KSHV-encoded interferon regulatory factors (IRFs) and thus contribute to PEL escape from interferon-mediated control of viral infection...
  36. ncbi request reprint Non-Hodgkin's lymphomas in the elderly: prospective studies with specifically devised chemotherapy regimens in 66 patients
    U Tirelli
    Division of Medical Oncology, Centro di Riferimento Oncologico, Aviano, Italy
    Eur J Cancer Clin Oncol 23:535-40. 1987
    ..We suggest that a combination regimen like E + P, suitable for oral administration, may be safely employed in a large fraction of pts with NHL...
  37. ncbi request reprint Primary effusion lymphoma cell lines harbouring human herpesvirus type-8
    A Carbone
    Division of Pathology, Centro di Riferimento Oncologico, IRCCS, Istituto Nazionale Tumori, Aviano, Italy
    Leuk Lymphoma 36:447-56. 2000
    ....
  38. ncbi request reprint Enzyme and immunohistochemistry of follicular hyperplasia in AIDS-related lymphadenopathy
    A Carbone
    Divisione di Anatomia Patologica, Centro di Riferimento Oncologico, Aviano, Italy
    Int J Biol Markers 2:87-94. 1987
    ..abstract truncated at 250 words)..
  39. ncbi request reprint Expression of the c-kit receptor in human lymphomas is restricted to Hodgkin's disease and CD30+ anaplastic large cell lymphomas
    A Pinto
    Leukemia Unit, Centro di Riferimento Oncologico, INRCCS, Aviano, Italy
    Blood 83:785-92. 1994
    ..The highly restricted expression of the c-kit product among human lymphomas to HD and ALCL provides a further biologic link between these two closely related lymphoma entities...
  40. ncbi request reprint KP1 (CD68)-positive large cell lymphomas: a histopathologic and immunophenotypic characterization of 12 cases
    A Carbone
    Division of Pathology, Istituto Nazionale di Ricovero e Cura a Carattere Scientifico, Aviano, Italy
    Hum Pathol 24:886-96. 1993
    ....
  41. ncbi request reprint Pathogenetic and histogenetic features of HIV-associated Hodgkin's disease
    R Dolcetti
    Division of Experimental Oncology 1, Centro di Riferimento Oncologico, IRCCS, National Cancer Institute, Via Pedemontana Occidentale 12, 33081 (PN, Aviano, Italy
    Eur J Cancer 37:1276-87. 2001
    ....
  42. ncbi request reprint Discordant HHV8 detection in a young HIV-negative patient with Kaposi's sarcoma and sarcoidosis
    G Di Gennaro
    Division of Medical Oncology A, National Cancer Institute, Aviano, Italy
    Clin Infect Dis 32:1100-2. 2001
    ..HHV8 sequences were detected with PCR only on KS lesions, whereas sarcoid tissues did not harbor HHV8 DNA. Immune dysfunction related to sarcoidosis may have facilitated the oncogenic role of HHV8 and the development of KS...
  43. ncbi request reprint [The pathology spectrum of AIDS-related non-Hodgkin's lymphoma]
    A Carbone
    Divisione di Anatomia Patologica e Citopatologia Diagnostica e di Screening, Istituto Nazionale Tumori, Aviano
    Pathologica 90:763-70. 1998
    ..However, despite their pathologic and molecular heterogeneity, AIDS-NHL have a common B-cell origin, although the precise stage of B-cell differentiation reflected by the different tumor types has not been clarified yet...
  44. ncbi request reprint Pathogenesis of human reactive-appearing "non-monomorphous" malignant lymphoproliferative disorders: a hypothesis
    M Boiocchi
    Division of Experimental Oncology 1, Centro di Riferimento Oncologico, Aviano, Italy
    Tumori 78:221-7. 1992
    ....
  45. ncbi request reprint Is the Epstein-Barr virus involved in Hodgkin's disease?
    M Boiocchi
    Division of Experimental Oncology 1, Aviano, Italy
    Tumori 75:345-50. 1989
    ..In light of this finding we are attempting to reconsider the abundant literature on this lymphoproliferative disorder, and suggest a reevaluation of the possibility that EBV could be etiologically involved in HD...
  46. ncbi request reprint Management of hematologic malignancies in the elderly: 15-year experience at the Aviano Cancer Center, Italy
    V Zagonel
    Medical Oncology Department, Centro di Riberimento Oncologico, IRCCS, Aviano, Italy
    Crit Rev Oncol Hematol 39:289-305. 2001
    ..Elaboration of a 'consensus' view will represent the challenge for all the investigators involved in such an important field of research...
  47. ncbi request reprint Total body irradiation and prednimustine in chronic lymphocytic leukemia and low grade non-Hodgkin's lymphomas. A 9-year experience at a single institution
    M Roncadin
    Radiotherapy Division, Centro di Riferimento Oncologico, Aviano, Italy
    Cancer 74:978-84. 1994
    ..The efficacy and toxicity of total body irradiation (TBI) in patients with chronic lymphocytic leukemia (CLL) and low grade non-Hodgkin's lymphomas (NHL) were evaluated...
  48. doi request reprint HIV-associated Hodgkin lymphoma
    Antonino Carbone
    Department of Pathology, Fondazione IRCCS, Istituto Nazionale Tumori, Milan, Italy
    Curr Opin HIV AIDS 4:3-10. 2009
    ..The focus of this review is on the current knowledge on epidemiology, pathology and treatment of HIV-associated Hodgkin lymphoma (HIV-HL)...
  49. ncbi request reprint Gastric cancer with bone marrow invasion at presentation: case-report and review of the literature
    D Crivellari
    Division of Medical Oncology, Centro di Riferimento Oncologico, Aviano, Italy
    Tumori 81:74-6. 1995
    ..Due to the disappearance of bone marrow infiltration, the patient was considered for curative resection of the primary gastric cancer. After 27 months the patient is alive and in clinical complete remission...
  50. ncbi request reprint Study of AIDS-related lymphadenopathy in the intraparotid and perisubmaxillary gland lymph nodes
    A Poletti
    Division of Pathology, Cancer Centre, Aviano, Italy
    J Oral Pathol 17:164-7. 1988
    ....
  51. ncbi request reprint Frequency of bcl-2/IgH translocation in patients with non-Hodgkin's lymphoma and chronic hepatitis C virus infection
    M Libra
    Division of Experimental Oncology 1, Centro di Riferimento Oncologico Aviano, Italy
    Minerva Gastroenterol Dietol 51:165-70. 2005
    ....
  52. pmc KSHV/HHV-8 associated lymph node based lymphomas in HIV seronegative subjects. Report of two cases with anaplastic large cell morphology and plasmablastic immunophenotype
    A Carbone
    Department of Pathology, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, IRCCS, Via Venezian 1, Milano I 20133, Italy
    J Clin Pathol 58:1039-45. 2005
    ..Interestingly, KSHV/HHV-8 associated lymphomas that present as solid or extracavitary based lesions in HIV seropositive patients without serous effusions have been reported recently...
  53. ncbi request reprint Type II mixed cryoglobulinaemia as an oligo rather than a mono B-cell disorder: evidence from GeneScan and MALDI-TOF analyses
    V De Re
    Division of Experimental Oncology I, Centro di Riferimento Oncologico Via Pedemontana Occidentale 12, 33081 Aviano PN, Italy
    Rheumatology (Oxford) 45:685-93. 2006
    ..To identify and characterize rheumatoid factor (RF)-producing B-cells and cryoprecipitate immunoglobulin (Ig) M in hepatitis C virus (HCV)-positive patients...
  54. doi request reprint IRF4 is modulated by CD40L and by apoptotic and anti-proliferative signals in Hodgkin lymphoma
    Donatella Aldinucci
    Experimental Oncology 2, Centro di Riferimento Oncologico, IRCCS National Cancer Institute, Aviano PN, Italy
    Br J Haematol 148:115-8. 2010
    ..These results demonstrated, for the first time, that IRF4 was up-modulated by CD40 engagement, and down-modulated by apoptotic and anti-proliferative signals, suggesting an involvement of IRF4 also in HL pathobiology...
  55. ncbi request reprint The classical Hodgkin's lymphoma microenvironment and its role in promoting tumour growth and immune escape
    Donatella Aldinucci
    Department of Experimental Oncology 2, Centro di Riferimento Oncologico, IRCCS National Cancer Institute, Aviano, PN, Italy
    J Pathol 221:248-63. 2010
    ....
  56. ncbi request reprint Expression of CCR5 receptors on Reed-Sternberg cells and Hodgkin lymphoma cell lines: involvement of CCL5/Rantes in tumor cell growth and microenvironmental interactions
    Donatella Aldinucci
    Experimental Oncology 2, Centro di Riferimento Oncologico, I R C C S, Aviano PN, Italy
    Int J Cancer 122:769-76. 2008
    ..Taken together, our results indicate a possible involvement of the CCR5/CCR5-ligands signaling in the regulation of H-RS cells growth and in the formation/maintenance of the typical tissue microenvironment of HL...
  57. ncbi request reprint Comparison of ultrasonography, hysteroscopy, and biopsy in the diagnosis of endometrial lesions in postmenopausal tamoxifen-treated patients
    Giorgio Giorda
    Division of Gynecologic Oncology, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, Aviano, Italy
    Acta Obstet Gynecol Scand 81:975-80. 2002
    ..At present, no proven recommendations can be made for the surveillance of tamoxifen-treated women. The aim of the present study was to evaluate ultrasonography and hysteroscopy in this setting...
  58. doi request reprint IRF4 silencing inhibits Hodgkin lymphoma cell proliferation, survival and CCL5 secretion
    Donatella Aldinucci
    Centro di Riferimento Oncologico, IRCCS National Cancer Institute, Aviano, Italy
    Br J Haematol 152:182-90. 2011
    ....
  59. ncbi request reprint Hodgkin and Reed-Sternberg cells express functional c-kit receptors and interact with primary fibroblasts from Hodgkin's disease-involved lymph nodes through soluble and membrane-bound stem cell factor
    Donatella Aldinucci
    Clinical and Experimental Haematology Research Unit, Centro di Riferimento Oncologico, I R C C S, Istituto Nazionale Tumori, Aviano, Italy
    Br J Haematol 118:1055-64. 2002
    ..Taken together, our data indicated the expression of functional c-kit receptor by H-RS cells and suggests a role of SCF in the pathobiology of cHD...
  60. ncbi request reprint Interobserver agreement of the dermoscopic diagnosis of 129 small melanocytic skin lesions
    Maria Antonietta Pizzichetta
    Division of Medical Oncology C and Oncology Prevention, Centro di Riferimento Oncologico, Via Pedemontana Occidentale 12, 33081 Aviano, PN, Italy
    Tumori 88:234-8. 2002
    ..The aim of the study was to investigate the interobserver agreement of standard dermoscopic criteria between two observers and the diagnostic validity of dermoscopic diagnosis by pattern analysis and by the ABCD rule...
  61. ncbi request reprint The role of interleukin-3 in classical Hodgkin's disease
    Donatella Aldinucci
    Clinical and Experimental Hematology Research Unit, Centro di Riferimento Oncologico, IRCCS, Aviano PN, Italy
    Leuk Lymphoma 46:303-11. 2005
    ..This review will outline the biological activity of IL-3 and summarize the evidence indicating IL-3 as a growth and anti-apoptotic factor for H-RS cells in classical HD...
  62. ncbi request reprint Nutrient intake and ovarian cancer: an Italian case-control study
    Ettore Bidoli
    Epidemiology Unit, Centro di Riferimento Oncologico, Aviano, Italy
    Cancer Causes Control 13:255-61. 2002
    ..The role of selected macronutrients, cholesterol, and fatty acids in the etiology of epithelial ovarian cancer was analyzed using data from a case-control study carried out in five Italian areas between January 1992 and December 1999...
  63. doi request reprint HCV inhibits antigen processing and presentation and induces oxidative stress response in gastric mucosa
    Valli De Re
    Experimental and Clinical Pharmacology, CRO Centro di Riferimento Oncologico, IRCCS National Cancer Institute, Aviano, Italy
    Proteomics Clin Appl 2:1290-9. 2008
    ..Both these processes facilitate immune escape and cell survival and probably contribute to HCV chronicization...
  64. ncbi request reprint Efficacy of CT-guided percutaneous needle biopsy in the diagnosis of malignant lymphoma at first presentation
    Luca Balestreri
    Department of Radiology, Centro di Riferimento Oncologico IRCCS, via Pedemontana Occ le 12, Aviano 33081, Italy
    Clin Imaging 29:123-7. 2005
    ....
  65. pmc Expression of functional interleukin-3 receptors on Hodgkin and Reed-Sternberg cells
    Donatella Aldinucci
    Clinical and Experimental Hematology Research Unit, Centro di Riferimento Oncologico, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Istituto Nazionale Tumori, Via Pedemontana Occidentale 12, Aviano I 33081, Italy
    Am J Pathol 160:585-96. 2002
    ..This data suggests an involvement of IL-3/IL-3R interactions in the cellular growth of HD through paracrine mechanisms...
  66. ncbi request reprint Characterization of immunologic and virological parameters in HIV-infected patients with primary effusion lymphoma during antiblastic therapy and highly active antiretroviral therapy
    Cecilia Simonelli
    Division of Medical Oncology A, National Cancer Institute, Aviano, Italy
    Clin Infect Dis 40:1022-7. 2005
    ..The aim of the present study was to evaluate the immunologic and virological parameters, including HHV-8 viremia, of 5 HIV-infected patients with PEL whose disease was diagnosed and treated at our institute...
  67. ncbi request reprint Expression of the monomeric 67-kd laminin-binding protein in human lymphomas as defined by MLuC5 monoclonal antibody and paraffin section immunohistochemistry
    A Carbone
    Division of Pathology, Istituto Nazionale di Ricovero e Cura a Carattere Scientifico, Aviano, Italy
    Hum Pathol 26:541-6. 1995
    ..Whether the detection of the 67 LR expression in these lymphoma subsets may be related to the aggressiveness of the disease remains to be ascertained...
  68. ncbi request reprint Micronutrients and ovarian cancer: an Italian case-control study
    E Bidoli
    Servizio di Epidemiologia, Centro di Riferimento Oncologico, Via Pedemontana Occ, 33081 Aviano, Italy
    IARC Sci Publ 156:357-60. 2002
  69. ncbi request reprint Dermoscopic criteria for melanoma in situ are similar to those for early invasive melanoma
    M A Pizzichetta
    Division of Preventive Oncology, Centro di Riferimento Oncologico-Aviano, Aviano, Italy
    Cancer 91:992-7. 2001
    ..Dermoscopic criteria appeared to be independent of CMIS lesions size...
  70. ncbi request reprint Hodgkin's disease: a disorder of dysregulated cellular cross-talk
    A Pinto
    The Leukemia Unit, I R C C S, Aviano, Italy
    Biotherapy 10:309-20. 1998
    ..Innovative therapeutic strategies aimed at blocking the pathways of dysregulated cellular cross-talk among H-RS cells and bystander reactive cell populations might be beneficial in the treatment of HD patients...
  71. ncbi request reprint Secondary cytoreductive surgery for patients with recurrent epithelial ovarian carcinoma
    C Scarabelli
    Division of Gynecologic Oncology, Centro di Riferimento Oncologico di Aviano, Istituto Nazionale di Ricovero e Cura a Carattere Scientifico, Via Pedemontana Occidentale No. 12, Aviano (PN, 33081, Italy
    Gynecol Oncol 83:504-12. 2001
    ..CONCLUSIONS: Patients who have documented gross disease preoperatively should be selected for a secondary debulking operation; the entity of surgical effort would be modulated in relation to previous treatment...
  72. ncbi request reprint Chronic hepatitis C in HIV infection: feasibility and sustained efficacy of therapy with interferon alfa-2b and tribavirin
    G Nasti
    Division of Oncological Medicine A, National Cancer Institute, Aviano, Pordenone, Italy
    AIDS 15:1783-7. 2001
    ..The sustained response achieved with the drug combination does not seem to be any better than that achieved with 12 months of monotherapy with interferon alfa-2b...
  73. doi request reprint The Germinal centre-derived lymphomas seen through their cellular microenvironment
    Antonino Carbone
    Department of Pathology and Laboratory and Transfusion Medicine, Istituto Nazionale Tumori, Milano, Italy
    Br J Haematol 145:468-80. 2009
    ....
  74. ncbi request reprint AIDS-related lymphomas: from pathogenesis to pathology
    Antonino Carbone
    Department of Pathology, Istituto Nazionale Tumori, Milano, Italy
    Br J Haematol 130:662-70. 2005
    ....
  75. ncbi request reprint Outcome in patients with non-hodgkin lymphoma and with or without human immunodeficiency virus infection
    Michele Spina
    Division of Medical Oncology A, National Cancer Institute, Aviano, Italy
    Clin Infect Dis 38:142-4. 2004
    ..4 for HIV-infected patients vs. 1 for HIV-negative patients; P=.24). Therefore, the achievement of complete remission should be the main goal in the treatment of patients with HIV-NHL...
  76. pmc Expression of cyclin-dependent kinase inhibitor p27(Kip1) in AIDS-related diffuse large-cell lymphomas is associated with Epstein-Barr virus-encoded latent membrane protein 1
    Annunziata Gloghini
    Division of Pathology, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, IRCCS, Aviano, Italy
    Am J Pathol 161:163-71. 2002
    ....
  77. ncbi request reprint Differential expression of cell adhesion molecules CD54/CD11a and CD58/CD2 by human melanoma cells and functional role in their interaction with cytotoxic cells
    M Altomonte
    Advanced Immunotherapeutics Unit, C R O, Aviano, Italy
    Cancer Res 53:3343-8. 1993
    ....
  78. ncbi request reprint Non-Hodgkin's lymphoma in the elderly: a retrospective evaluation of toxicity related to aggressive vs. conservative treatments
    U Tirelli
    Divisione di Oncologia Medica, Centro di Riferimento Oncologico, Aviano, Italia
    Tumori 74:433-8. 1988
    ..Prospective randomized trials with AM vs CM are clearly needed in elderly patients with advanced unfavorable NHL...
  79. ncbi request reprint Methylenetetrahydrofolate reductase genotype in diffuse large B-cell lymphomas with and without hypermethylation of the DNA repair gene O6-methylguanine DNA methyltransferase
    G Toffoli
    Unit of Experimental and Clinical Pharmacology, CRO National Cancer Institute, Aviano PN, Italy
    Int J Biol Markers 18:218-21. 2003
    ..These results indicate that MTHFR variants are not related to DLBCL development and MGMT hypermethylation...
  80. ncbi request reprint Aggressive forms of non-Hodgkin's lymphoma in two patients bearing coinfection of Epstein-Barr and hepatitis C viruses
    Massimo Libra
    Division of Experimental Oncology 1, Centro di Riferimento Oncologico Aviano, Istituto Nazionale Tumori, IRCCS, Via Pedemontana Occidentale 12, I 33081 Aviano, PN, Italy
    Int J Oncol 26:945-50. 2005
    ..Together, these data suggest that EBV infection may cooperate with HCV infection during progression of B-cell NHL in immunocompetent individuals. Such an interaction may accelerate the course of disease in B-cell NHL patients...
  81. ncbi request reprint Emerging pathways in the development of AIDS-related lymphomas
    Antonino Carbone
    Centro di Riferimento Oncologico IRCCS, Aviano, Italy
    Lancet Oncol 4:22-9. 2003
    ..New molecular and virological evidence of such pathways and a greater knowledge of other biological features of AIDS-related NHLs may lead to new targets for pathogenetically and biologically oriented therapies...
  82. doi request reprint Undifferentiated nasopharyngeal carcinoma from a nonendemic area: protective role of HLA allele products presenting conserved EBV epitopes
    Elisa Pasini
    Cancer Bioimmunotherapy Unit, IRCCS National Cancer Institute, Aviano PN, Italy
    Int J Cancer 125:1358-64. 2009
    ..These results have practical implications for the immunotherapy of UNPC...
  83. ncbi request reprint Non-Hodgkin's lymphoma and hepatitis C virus: a case-control study from northern and southern Italy
    Renato Talamini
    Servizio di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Aviano, Pordenone, Italy
    Int J Cancer 110:380-5. 2004
    ..In conclusion, HCV infection was associated with an increase in NHL risk, and the fraction of NHL cases attributable to HCV was 12.4% (range 6.3-18.5%)...
  84. ncbi request reprint Differentiating germinal center-derived lymphomas through their cellular microenvironment
    Antonino Carbone
    Department of Pathology and Laboratory and Transfusion Medicine, Istituto Nazionale Tumori, Milano, Italy
    Am J Hematol 84:435-8. 2009
    ..Am. J. Hematol., 2009. (c) 2009 Wiley-Liss, Inc...
  85. pmc Latent membrane protein 1 deletion mutants accumulate in reed-sternberg cells of human immunodeficiency virus-related Hodgkin's lymphoma
    Massimo Guidoboni
    Immunovirology and Biotherapy Unit, Department of Pre Clinical and Epidemiological Research, Centro di Riferimento Oncologico, IRCCS, National Cancer Institute, Via Pedemontana Occidentale 12, 33081 Aviano PN Italy
    J Virol 79:2643-9. 2005
    ....
  86. doi request reprint Spontaneous T cell responses to Epstein-Barr virus-encoded BARF1 protein and derived peptides in patients with nasopharyngeal carcinoma: bases for improved immunotherapy
    Debora Martorelli
    Cancer Bioimmunotherapy Unit, Centro di Riferimento Oncologico, IRCCS National Cancer Institute, Aviano, PN, Italy
    Int J Cancer 123:1100-7. 2008
    ....
  87. ncbi request reprint Will the "new biology" affect the future of histopathology?
    A Carbone
    Division of Pathology, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, IRCCS, Aviano, Italy
    Int J Biol Markers 16:1-4. 2001
    ..Moreover, as therapies are starting to be modelled after the distinctive molecular characteristics of a specific tumor, the availability of molecular tests to all patients will become a matter of great importance...
  88. ncbi request reprint Pathologic assessment of computerized tomography accuracy for the evaluation of the laryngeal cartilaginous framework in laryngopharyngeal carcinomas
    S Sulfaro
    Division of Pathology, Centro di Riferimento Oncologico, Aviano, Italy
    Tumori 75:156-62. 1989
    ..Moreover, false-positive cases were mainly due to proximity of the tumor to the cartilage. Clinical implications of these results are discussed...
  89. ncbi request reprint Prognostic factors in soft tissue sarcomas: a study of 395 patients
    P D Stefanovski
    Division of Medical Oncology, Centro di Riferimento Oncologico, Aviano, Italy
    Eur J Surg Oncol 28:153-64. 2002
    ..The aim of this study was to report prognostic factors, end-points of local recurrence, distant recurrence, post-metastasis survival, and overall survival in a cohort of patients with soft tissue sarcomas...
  90. ncbi request reprint Sentinel and nonsentinel node status in stage IB and II melanoma patients: two-step prognostic indicators of survival
    Natale Cascinelli
    Nuclear Medicine Unit, Istituto Nazionale Tumori, Milan, Italy
    J Clin Oncol 24:4464-71. 2006
    ..To evaluate the prognostic significance of sentinel node biopsy in the management of stage IB and II melanoma patients, and to evaluate the status of nonsentinel nodes as a "second step key factor" to assess the prognosis of these patients...
  91. doi request reprint Multiple gene expression analyses in human lymphoid tissues by taqman low-density array using amplified rna isolated from paraffin-embedded samples
    Annunziata Gloghini
    Department of Pathology, Fondazione IRCCS, Istituto Nazionale Tumori, Milano, Italy
    Diagn Mol Pathol 18:156-64. 2009
    ..Consequently, TaqMan low-density array technology could be used successfully for the analysis of archival fixed and paraffin-embedded lymphoid tissue...
  92. doi request reprint PEL and HHV8-unrelated effusion lymphomas: classification and diagnosis
    Antonino Carbone
    Department of Pathology, Istituto Nazionale Tumori, Milano, Italy
    Cancer 114:225-7. 2008
  93. ncbi request reprint A spindle cell variant of diffuse large B-cell lymphoma possesses genotypic and phenotypic markers characteristic of a germinal center B-cell origin
    Antonino Carbone
    Department of Pathology, Istituto Nazionale Tumori, Milano, Italy
    Mod Pathol 19:299-306. 2006
    ..The germinal center phenotype, with restricted expression of BCL-6, was associated with the presence of a primary extranodal origin, normal lactate dehydrogenase levels, and good response to treatment...
  94. doi request reprint Anticancer cell therapy with TRAIL-armed CD34+ progenitor cells
    Carmelo Carlo-Stella
    University of Milano, Istituto Nazionale Tumori, Department of Medical Oncology, Milano, Italy
    Adv Exp Med Biol 610:100-11. 2008
  95. ncbi request reprint Is diversified clinical presentation of Kaposi sarcoma-associated herpesvirus/human herpesvirus-8-associated lymphoma related to the host's changed conditions?
    Antonino Carbone
    Department of Pathology, Istituto Nazionale Tumori, Milan, Italy
    Clin Lymphoma Myeloma 6:153-5. 2005
  96. ncbi request reprint Salivary gland B cell lymphoproliferative disorders in Sjögren's syndrome present a restricted use of antigen receptor gene segments similar to those used by hepatitis C virus-associated non-Hodgkins's lymphomas
    Valli De Re
    Division of Experimental Oncology 1, Centro di Riferimento Oncologico, IRCS, Aviano, Italy
    Eur J Immunol 32:903-10. 2002
    ....
  97. ncbi request reprint Analysis of aberrant somatic hypermutation (SHM) in non-Hodgkin's lymphomas of patients with chronic HCV infection
    Massimo Libra
    Experimental Oncology 1, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, Istituto di Ricovero e Cura a Carattere Scientifico, Aviano, Italy
    J Pathol 206:87-91. 2005
    ..This indicates that, unlike B-cell lymphomas from HCV-negative patients, aberrant SHM may not contribute significantly to malignant transformation in HCV-associated B-cell lymphomas...
  98. ncbi request reprint Retinoic acid inhibits the proliferative response induced by CD40 activation and interleukin-4 in mantle cell lymphoma
    Massimo Guidoboni
    Immunovirology and Biotherapy Unit, Department of Pre Clinical and Epidemiological Research, IRCCS National Cancer Institute, Aviano PN, Italy
    Cancer Res 65:587-95. 2005
    ....
  99. ncbi request reprint Transcription deregulation at the 15q25 locus in association with lung adenocarcinoma risk
    Felicia S Falvella
    Fondazione IRCCS, Istituto Nazionale Tumori, Milan, Italy
    Clin Cancer Res 15:1837-42. 2009
    ....
  100. ncbi request reprint KSHV/HHV8-associated lymphomas
    Antonino Carbone
    Department of Pathology, Istituto Nazionale Tumori, Milan, Italy
    Br J Haematol 140:13-24. 2008
    ..These include the addition of antiviral therapy as well as inhibition of specific cellular targets...
  101. doi request reprint Human CD34+ cells engineered to express membrane-bound tumor necrosis factor-related apoptosis-inducing ligand target both tumor cells and tumor vasculature
    Cristiana Lavazza
    Medical Oncology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale Tumori, Milano, Italy
    Blood 115:2231-40. 2010
    ..These results demonstrate that tumor homing of CD34-TRAIL+ cells induces early vascular disruption, resulting in hemorrhagic necrosis and tumor destruction...