Gustavo Baldassarre

Summary

Affiliation: Centro di Riferimento Oncologico
Country: Italy

Publications

  1. pmc FEZ1/LZTS1 is down-regulated in high-grade bladder cancer, and its restoration suppresses tumorigenicity in transitional cell carcinoma cells
    Andrea Vecchione
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Am J Pathol 160:1345-52. 2002
  2. pmc Fez1/Lzts1 a new mitotic regulator implicated in cancer development
    Andrea Vecchione
    Department of Molecular Virology, Immunology and Medical Genetics and Comprehensive Cancer Center, Ohio State University, OH, USA
    Cell Div 2:24. 2007
  3. ncbi request reprint p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion
    Gustavo Baldassarre
    Oncologia Sperimentale 2, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, IRCCS, Aviano 33081, Italy
    Cancer Cell 7:51-63. 2005
  4. ncbi request reprint Linking inflammation to cell cycle progression
    Gustavo Baldassarre
    Divisione di Oncologia Sperimentale 2, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, IRCCS Aviano 33081, Italy
    Curr Pharm Des 10:1653-66. 2004
  5. pmc p27kip1 controls cell morphology and motility by regulating microtubule-dependent lipid raft recycling
    Barbara Belletti
    Division of Experimental Oncology 2, Centro di Riferimento Oncologico, National Cancer Institute, Via Franco Gallini, 2, 33081 Aviano, Italy
    Mol Cell Biol 30:2229-40. 2010
  6. pmc The tumor suppressor functions of p27(kip1) include control of the mesenchymal/amoeboid transition
    Stefania Berton
    Division of Experimental Oncology 2, Centro di Riferimento Oncologico, Aviano, Italy
    Mol Cell Biol 29:5031-45. 2009
  7. pmc Stathmin activity influences sarcoma cell shape, motility, and metastatic potential
    Barbara Belletti
    Division of Experimental Oncology 2, Division of Pathology, and Clinical and Experimental Hematology Research Unit, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, IRCCS Aviano 33081, Italy
    Mol Biol Cell 19:2003-13. 2008
  8. pmc Role of T198 modification in the regulation of p27(Kip1) protein stability and function
    Monica Schiappacassi
    Division of Experimental Oncology 2, Centro di Riferimento Oncologico, National Cancer Institute, Aviano, Italy
    PLoS ONE 6:e17673. 2011
  9. doi request reprint p27Kip1 expression inhibits glioblastoma growth, invasion, and tumor-induced neoangiogenesis
    Monica Schiappacassi
    Division of Experimental Oncology 2, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, IRCCS, Via Franco Gallini, 2 33081 Aviano, Italy
    Mol Cancer Ther 7:1164-75. 2008
  10. pmc Stathmin regulates mutant p53 stability and transcriptional activity in ovarian cancer
    Maura Sonego
    Division of Experimental Oncology 2, Centro di Riferimento Oncologico, National Cancer Institute, Aviano, Italy
    EMBO Mol Med 5:707-22. 2013

Collaborators

Detail Information

Publications22

  1. pmc FEZ1/LZTS1 is down-regulated in high-grade bladder cancer, and its restoration suppresses tumorigenicity in transitional cell carcinoma cells
    Andrea Vecchione
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Am J Pathol 160:1345-52. 2002
    ..These results suggest that FEZ1/LZTS1 gene plays a role in the development of TCC of the urinary bladder by acting as a bona fide tumor suppressor gene both in vitro and in vivo...
  2. pmc Fez1/Lzts1 a new mitotic regulator implicated in cancer development
    Andrea Vecchione
    Department of Molecular Virology, Immunology and Medical Genetics and Comprehensive Cancer Center, Ohio State University, OH, USA
    Cell Div 2:24. 2007
    ..Recently we identified a new player: FEZ1/LZTS1 that contributes to the fine-tuning of the molecular events that determine progression through mitosis, and here will review its role in cancer development and in M phase regulation...
  3. ncbi request reprint p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion
    Gustavo Baldassarre
    Oncologia Sperimentale 2, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, IRCCS, Aviano 33081, Italy
    Cancer Cell 7:51-63. 2005
    ..This study provides a functional link between proliferation and invasion of tumor cells based on diverse activities of p27(kip1) in different subcellular compartments...
  4. ncbi request reprint Linking inflammation to cell cycle progression
    Gustavo Baldassarre
    Divisione di Oncologia Sperimentale 2, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, IRCCS Aviano 33081, Italy
    Curr Pharm Des 10:1653-66. 2004
    ....
  5. pmc p27kip1 controls cell morphology and motility by regulating microtubule-dependent lipid raft recycling
    Barbara Belletti
    Division of Experimental Oncology 2, Centro di Riferimento Oncologico, National Cancer Institute, Via Franco Gallini, 2, 33081 Aviano, Italy
    Mol Cell Biol 30:2229-40. 2010
    ....
  6. pmc The tumor suppressor functions of p27(kip1) include control of the mesenchymal/amoeboid transition
    Stefania Berton
    Division of Experimental Oncology 2, Centro di Riferimento Oncologico, Aviano, Italy
    Mol Cell Biol 29:5031-45. 2009
    ..Thus, we highlight here a new p27 function in driving cell plasticity that is associated with its C-terminal portion and does not depend on the control of cyclin-dependent kinase activity...
  7. pmc Stathmin activity influences sarcoma cell shape, motility, and metastatic potential
    Barbara Belletti
    Division of Experimental Oncology 2, Division of Pathology, and Clinical and Experimental Hematology Research Unit, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, IRCCS Aviano 33081, Italy
    Mol Biol Cell 19:2003-13. 2008
    ..Our results indicate that stathmin plays a significant role in tumor metastasis formation, a finding that could lead to exploitation of stathmin as a target of new antimetastatic drugs...
  8. pmc Role of T198 modification in the regulation of p27(Kip1) protein stability and function
    Monica Schiappacassi
    Division of Experimental Oncology 2, Centro di Riferimento Oncologico, National Cancer Institute, Aviano, Italy
    PLoS ONE 6:e17673. 2011
    ..On the other hand T198 phosphorylation favors p27/stathmin interaction eventually contributing to the regulation of cell motility, supporting the hypothesis that the presence of T198 is fundamental for the regulation of p27 functions...
  9. doi request reprint p27Kip1 expression inhibits glioblastoma growth, invasion, and tumor-induced neoangiogenesis
    Monica Schiappacassi
    Division of Experimental Oncology 2, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, IRCCS, Via Franco Gallini, 2 33081 Aviano, Italy
    Mol Cancer Ther 7:1164-75. 2008
    ....
  10. pmc Stathmin regulates mutant p53 stability and transcriptional activity in ovarian cancer
    Maura Sonego
    Division of Experimental Oncology 2, Centro di Riferimento Oncologico, National Cancer Institute, Aviano, Italy
    EMBO Mol Med 5:707-22. 2013
    ..Overall our data support the hypothesis that the expression of stathmin and p53 could be useful for the identification of high risk patients that will benefit from a therapy specifically acting on mitotic cancer cells...
  11. doi request reprint Stathmin: a protein with many tasks. New biomarker and potential target in cancer
    Barbara Belletti
    National Cancer Institute, Centro di Riferimento Oncologico, Division of Experimental Oncology 2, Via Franco Gallini, 2, 33081 Aviano, Italy
    Expert Opin Ther Targets 15:1249-66. 2011
    ..Accordingly, stathmin is an important target of the main regulator of M phase, cyclin-dependent kinase 1...
  12. doi request reprint Targeted intraoperative radiotherapy impairs the stimulation of breast cancer cell proliferation and invasion caused by surgical wounding
    Barbara Belletti
    Experimental Oncology, Centro di Riferimento Oncologico, Istituto di Ricovero e Cura a Carattere Scientifico, Aviano, Italy
    Clin Cancer Res 14:1325-32. 2008
    ..The proportional reduction of this risk by radiotherapy does not depend on the extent of surgery, suggesting that radiotherapy, in addition to killing tumor cells, may influence the tumor microenvironment...
  13. ncbi request reprint Glial cell line-derived neurotrophic factor induces proliferative inhibition of NT2/D1 cells through RET-mediated up-regulation of the cyclin-dependent kinase inhibitor p27(kip1)
    Gustavo Baldassarre
    Istituto Nazionale Tumori, Via M Semmola, 80131, Naples, Italy
    Oncogene 21:1739-49. 2002
    ..Both DNA synthesis inhibition and SSEA-3 down-regulation are prevented if p27(kip1) expression is blocked by an antisense construct, which demonstrates that RET-triggered effects are mediated by p27(kip1)...
  14. doi request reprint Alteration of G1/S transition regulators influences recurrences in head and neck squamous carcinomas
    Vincenzo Canzonieri
    Division of Pathology, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, IRCCS, Aviano, Italy
    J Cell Physiol 227:233-8. 2012
    ....
  15. ncbi request reprint Take your "M" time
    Gustavo Baldassarre
    Division of Experimental Oncology 2, Centro di Riferimento Oncologico, Aviano, Italy
    Cell Cycle 6:2087-90. 2007
    ..As a consequence, Lzts1 absence in mice results in accelerated mitotic progression, improper chromosome segregation and, eventually, in increased incidence of both spontaneous and carcinogen-induced cancer formation...
  16. ncbi request reprint Reduced E-cadherin expression contributes to the loss of p27kip1-mediated mechanism of contact inhibition in thyroid anaplastic carcinomas
    Maria Letizia Motti
    Dipartimento di Biologia e Patologia Cellulare e Molecolare L Califano Facoltà di Medicina e Chirurgia, Universita Federico II, Via S Pansini 5, 80131, Napoli, Italy
    Carcinogenesis 26:1021-34. 2005
    ..In summary, our data indicate that the altered response to contact inhibition exhibited by thyroid anaplastic cancer cells is due to the failure to upregulate p27(Kip1) in response to cell-cell interactions...
  17. doi request reprint E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer
    Fabio Petrocca
    Department of Molecular Virology, Immunology and Medical Genetics, Human Cancer Genetics Program, Ohio State University, 460 West 12th Avenue, Columbus, OH 43210, USA
    Cancer Cell 13:272-86. 2008
    ..Together, these results suggest that the miR-106b-25 cluster is involved in E2F1 posttranscriptional regulation and may play a key role in the development of TGFbeta resistance in gastric cancer...
  18. pmc Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development
    Andrea Vecchione
    Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    Cancer Cell 11:275-89. 2007
    ..Accordingly, Lzts1 deficiency was associated with an increased incidence of both spontaneous and carcinogen-induced cancers in mice...
  19. ncbi request reprint Familial cancer associated with a polymorphism in ARLTS1
    George Adrian Calin
    Thomas Jefferson University, Philadelphia, USA
    N Engl J Med 352:1667-76. 2005
    ..The finding of hemizygous or homozygous deletions at band 14 on chromosome 13 in a variety of neoplasms suggests the presence of a tumor-suppressor locus telomeric to the RB1 gene...
  20. ncbi request reprint HMGA1 protein expression sensitizes cells to cisplatin-induced cell death
    Gustavo Baldassarre
    Kimmel Cancer Center, Jefferson Medical College, Philadelphia, PA 19107, USA
    Oncogene 24:6809-19. 2005
    ....
  21. ncbi request reprint Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas
    Monica Fedele
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Centro di Endocrinologia ed Oncologia Sperimentale del CNR, Facoltà di Medicina e Chirurgia di Napoli, Federico II Università degli Studi di Napoli, Via Pansini 5, 80131 Naples, Italy
    Oncogene 21:3190-8. 2002
    ..These transgenic mice may represent an important tool for the study of this kind of neoplasia...
  22. ncbi request reprint Haploinsufficiency of the Hmga1 gene causes cardiac hypertrophy and myelo-lymphoproliferative disorders in mice
    Monica Fedele
    Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Italy
    Cancer Res 66:2536-43. 2006
    ..Therefore, the data reported here indicate the critical role of HMGA1 in heart development and growth, and reveal an unsuspected antioncogenic potential for this gene in hematologic malignancies...