F I Wolf

Summary

Affiliation: Catholic University
Country: Italy

Publications

  1. ncbi Magnesium in cell proliferation and differentiation
    F I Wolf
    Institute of General Pathology and Giovanni XXIII Cancer Research Center, Catholic University of Sacred Heart, Faculty of Medicine, L go F Vito, 1, 00168 Roma, Italy
    Front Biosci 4:D607-17. 1999
  2. ncbi DNA oxidative damage during differentiation of HL-60 human promyelocytic leukemia cells
    V Covacci
    Institute of General Pathology and Giovanni XXIII Cancer Research Center, Faculty of Medicine, Catholic University of Sacred Heart, Rome, Italy
    Chem Res Toxicol 14:1492-7. 2001
  3. ncbi Expression of vascular endothelial growth factor and its receptors in the cochlea of various experimental animals
    Pasqualina M Picciotti
    Institute of Otorhinolaryngology, School of Medicine, Catholic University of the Sacred Heart, L go A Gemelli 8, 00168 Rome, Italy
    Acta Otolaryngol 125:1152-7. 2005
  4. doi Magnesium and its transporters in cancer: a novel paradigm in tumour development
    Federica I Wolf
    Istituto di Patologia Generale, Facoltà di Medicina e Chirurgia A Gemelli, Universita Cattolica del Sacro Cuore, Largo F Vito 1, 00168 Rome, Italy
    Clin Sci (Lond) 123:417-27. 2012
  5. ncbi Regulation of magnesium content during proliferation of mammary epithelial cells (HC-11)
    Federica I Wolf
    Institute of General Pathology and Giovanni XXIII Cancer Research Centre, Catholic University of Sacred Heart, Faculty of Medicine, L go F Vito, 1 00168 Rome, Italy
    Front Biosci 9:2056-62. 2004
  6. ncbi Peripheral lymphocyte 8-OHdG levels correlate with age-associated increase of tissue oxidative DNA damage in Sprague-Dawley rats. Protective effects of caloric restriction
    Federica I Wolf
    Institute of General Pathology and Giovanni XXIII Cancer Research Center, School of Medicine, Catholic University of Sacred Heart, L go F Vito, 1 Rome, Italy
    Exp Gerontol 40:181-8. 2005
  7. ncbi 50-Hz extremely low frequency electromagnetic fields enhance cell proliferation and DNA damage: possible involvement of a redox mechanism
    Federica I Wolf
    Institute of General Pathology and Giovanni XXIII Cancer Research Center, L go F Vito, 1 00168 Rome, Italy
    Biochim Biophys Acta 1743:120-9. 2005
  8. ncbi Magnesium and neoplasia: from carcinogenesis to tumor growth and progression or treatment
    F I Wolf
    Istituto di Patologia Generale, e Centro di Ricerche Oncologiche Giovanni XXIII, Facolta di Medicina, Universita Cattolica del Sacro Cuore, Largo F Vito, 100168 Rome, Italy
    Arch Biochem Biophys 458:24-32. 2007
  9. ncbi Cell (patho)physiology of magnesium
    Federica I Wolf
    Istituto di Patologia generale e Centro di Ricerche Oncologiche Giovanni XXIII, Facolta di Medicina, Universita Cattolica del Sacro Cuore, Largo F Vito 1, 00168 Roma, Italy
    Clin Sci (Lond) 114:27-35. 2008
  10. ncbi Magnesium and the control of cell proliferation: looking for a needle in a haystack
    Federica I Wolf
    Istituto di Patologia generale e Centro di Ricerche Oncologiche Giovanni XXIII, Universita Cattolica del Sacro Cuore, Facolta di Medicina A Gemelli, 00168 Roma, Italy
    Magnes Res 21:83-91. 2008

Detail Information

Publications35

  1. ncbi Magnesium in cell proliferation and differentiation
    F I Wolf
    Institute of General Pathology and Giovanni XXIII Cancer Research Center, Catholic University of Sacred Heart, Faculty of Medicine, L go F Vito, 1, 00168 Roma, Italy
    Front Biosci 4:D607-17. 1999
    ..On their whole, these data strongly suggest that regulation of intracellular Mg availability parallels the molecular control of cell proliferation, and maybe also cell differentiation and death...
  2. ncbi DNA oxidative damage during differentiation of HL-60 human promyelocytic leukemia cells
    V Covacci
    Institute of General Pathology and Giovanni XXIII Cancer Research Center, Faculty of Medicine, Catholic University of Sacred Heart, Rome, Italy
    Chem Res Toxicol 14:1492-7. 2001
    ..These results illustrate correlations between the oxidant/antioxidant balance and DNA damage and suggest that the capability of a cell population to withstand oxidative stress and DNA damage may depend on its degree of differentiation...
  3. ncbi Expression of vascular endothelial growth factor and its receptors in the cochlea of various experimental animals
    Pasqualina M Picciotti
    Institute of Otorhinolaryngology, School of Medicine, Catholic University of the Sacred Heart, L go A Gemelli 8, 00168 Rome, Italy
    Acta Otolaryngol 125:1152-7. 2005
    ....
  4. doi Magnesium and its transporters in cancer: a novel paradigm in tumour development
    Federica I Wolf
    Istituto di Patologia Generale, Facoltà di Medicina e Chirurgia A Gemelli, Universita Cattolica del Sacro Cuore, Largo F Vito 1, 00168 Rome, Italy
    Clin Sci (Lond) 123:417-27. 2012
    ....
  5. ncbi Regulation of magnesium content during proliferation of mammary epithelial cells (HC-11)
    Federica I Wolf
    Institute of General Pathology and Giovanni XXIII Cancer Research Centre, Catholic University of Sacred Heart, Faculty of Medicine, L go F Vito, 1 00168 Rome, Italy
    Front Biosci 9:2056-62. 2004
    ....
  6. ncbi Peripheral lymphocyte 8-OHdG levels correlate with age-associated increase of tissue oxidative DNA damage in Sprague-Dawley rats. Protective effects of caloric restriction
    Federica I Wolf
    Institute of General Pathology and Giovanni XXIII Cancer Research Center, School of Medicine, Catholic University of Sacred Heart, L go F Vito, 1 Rome, Italy
    Exp Gerontol 40:181-8. 2005
    ..Immunohistochemistry might be exploited as a rapid and simple techniques for measuring lymphocytes oxidative DNA damage in large scale studies...
  7. ncbi 50-Hz extremely low frequency electromagnetic fields enhance cell proliferation and DNA damage: possible involvement of a redox mechanism
    Federica I Wolf
    Institute of General Pathology and Giovanni XXIII Cancer Research Center, L go F Vito, 1 00168 Rome, Italy
    Biochim Biophys Acta 1743:120-9. 2005
    ..This information may be of value for appraising the pathophysiologic consequences of an exposure to ELF-EMF...
  8. ncbi Magnesium and neoplasia: from carcinogenesis to tumor growth and progression or treatment
    F I Wolf
    Istituto di Patologia Generale, e Centro di Ricerche Oncologiche Giovanni XXIII, Facolta di Medicina, Universita Cattolica del Sacro Cuore, Largo F Vito, 100168 Rome, Italy
    Arch Biochem Biophys 458:24-32. 2007
    ....
  9. ncbi Cell (patho)physiology of magnesium
    Federica I Wolf
    Istituto di Patologia generale e Centro di Ricerche Oncologiche Giovanni XXIII, Facolta di Medicina, Universita Cattolica del Sacro Cuore, Largo F Vito 1, 00168 Roma, Italy
    Clin Sci (Lond) 114:27-35. 2008
    ..The latest findings pave the road towards a new and deeper appreciation of magnesium homoeostasis and its role in the regulation of essential cell functions...
  10. ncbi Magnesium and the control of cell proliferation: looking for a needle in a haystack
    Federica I Wolf
    Istituto di Patologia generale e Centro di Ricerche Oncologiche Giovanni XXIII, Universita Cattolica del Sacro Cuore, Facolta di Medicina A Gemelli, 00168 Roma, Italy
    Magnes Res 21:83-91. 2008
    ..New and deeper appreciation of magnesium homeostasis will help in delineating the key role of this cation in the regulation of normal or pathologic cell proliferation...
  11. doi Magnesium deficiency affects mammary epithelial cell proliferation: involvement of oxidative stress
    Federica I Wolf
    Istituto di Patologia Generale, e Centro di Ricerche Oncologiche Giovanni XXIII, Facolta di Medicina, Universita Cattolica del Sacro Cuore, Rome, Italy
    Nutr Cancer 61:131-6. 2009
    ..Of note, GST has been shown to modulate cell growth; therefore, we suggest that in low-Mg cells, GST upregulation might have a dual role in protecting against oxidative stress and in modulating cell proliferation...
  12. doi Magnesium and tumors: ally or foe?
    Federica I Wolf
    Universita Cattolica del Sacro Cuore, Istituto di Patologia generale e Centro di Ricerche Oncologiche Giovanni XXIII, Facolta di Medicina A Gemelli, Roma, Italy
    Cancer Treat Rev 35:378-82. 2009
    ..Inflammatory responses to hypomagnesaemia should also be considered. Translating biology into clinical facts will therefore require a deeper understanding of such a complexity...
  13. ncbi Hypomagnesaemia in oncologic patients: to treat or not to treat?
    Federica I Wolf
    Universita Cattolica del Sacro Cuore, Istituto di Patologia generale e Centro di Ricerche Oncologiche Giovanni XXIII, Facolta di Medicina A Gemelli, Roma, Italy
    Magnes Res 22:5-9. 2009
    ..Translating these results into clinical settings may help in designing suitable studies to better evaluate the consequences of hypomagnesaemia in cancer patients...
  14. doi Modulation of TRPM6 and Na(+)/Mg(2+) exchange in mammary epithelial cells in response to variations of magnesium availability
    Federica I Wolf
    Istituto di Patologia Generale e Centro di Ricerche Giovanni XXIII, Facolta di Medicina A Gemelli, Universita Cattolica del Sacro Cuore, Roma, Italy
    J Cell Physiol 222:374-81. 2010
    ..These results show, for the first time, that TRPM6 contributes to regulating magnesium influx in mammary epithelial cells, similar to what is known for intestine and kidney...
  15. doi MagT1: a highly specific magnesium channel with important roles beyond cellular magnesium homeostasis
    Federica I Wolf
    Istituto di Patologia generale e Centro di Ricerche Oncologiche Giovanni XXIII, Facoltà di Medicina e Chirurgia A Gemelli, Universita Cattolica del Sacro Cuore, Rome, Italy
    Magnes Res 24:S86-91. 2011
    ..As our knowledge of magnesium advances, it becomes increasingly clear that a deeper understanding of magnesium homeostasis is the key for a deeper insight into relevant pathophysiological conditions, and their treatment...
  16. ncbi TRPM7: channeling the future of cellular magnesium homeostasis?
    Federica I Wolf
    Institute of General Pathology and Giovanni XXIII Cancer Research Centre, Faculty of Medicine, Catholic University of the Sacred Heart, Rome, Italy
    Sci STKE 2004:pe23. 2004
    ..Likewise, these findings will offer guidelines for research on disease states that are characterized by Mg imbalance...
  17. ncbi Oxidative DNA damage as a marker of aging in WI-38 human fibroblasts
    Federica I Wolf
    School of Medicine, Institute of General Pathology and Giovanni XXIII Cancer Research Center, Catholic University of Sacred Heart, L go F Vito 1, 00168 Rome, Italy
    Exp Gerontol 37:647-56. 2002
    ..Measurements of oxidative DNA damage might therefore be exploited as reliable marker of cellular aging...
  18. ncbi Chemistry and biochemistry of magnesium
    Federica I Wolf
    Institute of General Pathology and Giovanni XXIII Cancer Research Centre, School of Medicine, Catholic University of Sacred Heart, L go F Vito, 100168, Rome, Italy
    Mol Aspects Med 24:3-9. 2003
  19. ncbi Cell physiology of magnesium
    Federica I Wolf
    Giovanni XXIII Cancer Research Centre and Institute of General Pathology, Catholic University School of Medicine, L go F Vito, 1, 00168, Roma, Italy
    Mol Aspects Med 24:11-26. 2003
  20. ncbi Resveratrol, a natural phenolic compound, inhibits cell proliferation and prevents oxidative DNA damage
    A Sgambato
    Centro di Ricerche Oncologiche Giovanni XXIII, Istituto di Patologia Generale, Catholic University, Largo Francesco Vito 1, 00168, Rome, Italy
    Mutat Res 496:171-80. 2001
    ..Taken together our results suggest that resveratrol can act as an antimutagenic/anticarcinogenic agent by preventing oxidative DNA damage which plays a pivotal role in the carcinogenic activity of many genotoxic agents...
  21. ncbi Isolation of normal epithelial cells adapted to grow at nonphysiological concentration of magnesium
    A Sgambato
    Centro di Ricerche Oncologiche Giovanni XXIII, Istituto di Patologia Generale, Universita Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168 Rome, Italy
    Biochem Biophys Res Commun 286:752-7. 2001
    ....
  22. ncbi Magnesium depletion causes growth inhibition, reduced expression of cyclin D1, and increased expression of P27Kip1 in normal but not in transformed mammary epithelial cells
    A Sgambato
    Centro di Ricerche Oncologiche Giovanni XXIII, Istituto di Patologia Generale, Universita Cattolica del Sacro Cuore, Rome, Italy
    J Cell Physiol 180:245-54. 1999
    ..These data suggest that normal but not transformed mammary epithelial cells are inhibited by extracellular Mg2+ restriction and that this effect might be mediated by changes in the levels of expression of both cyclin D1 and p27Kip1...
  23. ncbi Differentiation of HL-60 promyelocytic leukemia cells is accompanied by a modification of magnesium homeostasis
    F I Wolf
    Institute of General Pathology and Giovanni XXIII Cancer Research Center, Catholic University of Sacred Heart, Roma, Italy
    J Cell Biochem 71:441-8. 1998
    ..Stimulation of magnesium efflux is paralleled by an increase of [Mg2+]i which reflects a release of magnesium from the bound cation pool...
  24. ncbi Age-dependent modifications of expression level of VEGF and its receptors in the inner ear
    Pasqualina Picciotti
    Institute of Otolaryngology, A Gemelli University Hospital, Università Cattolica del Sacro Cuore School of Medicine, Rome, Italy
    Exp Gerontol 39:1253-8. 2004
    ....
  25. ncbi Beta-carotene regulates NF-kappaB DNA-binding activity by a redox mechanism in human leukemia and colon adenocarcinoma cells
    Paola Palozza
    Institute of General Pathology, Catholic University, Rome, Italy
    J Nutr 133:381-8. 2003
    ..These data suggest that the redox regulation of NF-kappaB induced by beta-carotene is involved in the growth-inhibitory and proapoptotic effects of the carotenoid in tumor cells...
  26. ncbi Regulation of cell cycle progression and apoptosis by beta-carotene in undifferentiated and differentiated HL-60 leukemia cells: possible involvement of a redox mechanism
    Paola Palozza
    Institute of General Pathology, Catholic University, Rome, Italy
    Int J Cancer 97:593-600. 2002
    ..They also suggest that differentiated cells may be less susceptible to the carotenoid than highly neoplastic undifferentiated cells...
  27. ncbi beta-Carotene exacerbates DNA oxidative damage and modifies p53-related pathways of cell proliferation and apoptosis in cultured cells exposed to tobacco smoke condensate
    Paola Palozza
    Institute of General Pathology, Catholic University, Rome, Italy
    Carcinogenesis 25:1315-25. 2004
    ..This study supports the evidence for potential detrimental effects of an association between beta-carotene and cigarette smoke condensate...
  28. ncbi Mechanism of activation of caspase cascade during beta-carotene-induced apoptosis in human tumor cells
    Paola Palozza
    Institute of General Pathology, Catholic University, Largo F Vito 1, 00168 Rome, Italy
    Nutr Cancer 47:76-87. 2003
    ..These results support a pharmacological role for beta-Carotene as a candidate antitumor agent and show a possible sequence of molecular events by which this molecule may induce apoptosis in tumor cells...
  29. ncbi DNA damage and apoptosis induction by the pesticide Mancozeb in rat cells: involvement of the oxidative mechanism
    Gabriella Calviello
    Institute of General Pathology, Catholic University L go F Vito, 1 00168 Rome, Italy
    Toxicol Appl Pharmacol 211:87-96. 2006
    ..On the other hand, the proapoptotic effect of Mancozeb suggests its possible relevance in the pathogenesis of neurodegenerative diseases, often related to the exposition of pesticides...
  30. ncbi Magnesium deficiency and endothelial dysfunction: is oxidative stress involved?
    Federica I Wolf
    Istituto di Patologia Generale, e Centro di Ricerche Oncologiche Giovanni XXIII, Facolta di Medicina, Universita Cattolica del Sacro Cuore, Roma, Italy
    Magnes Res 21:58-64. 2008
    ..We conclude that low Mg transiently leads to pro-oxidant effects. We suggest that different molecules, including pro-inflammatory cytokines, might be involved in promoting endothelial dysfunction...
  31. doi Intracellular magnesium detection: imaging a brighter future
    Valentina Trapani
    Istituto di Patologia generale e Centro di Ricerche Oncologiche Giovanni XXIII, Facoltà di Medicina e Chirurgia A Gemelli, Universita Cattolica del Sacro Cuore, Rome, Italy
    Analyst 135:1855-66. 2010
    ..We highlight the advantages of last-generation fluorescent indicators and discuss a number of challenges and opportunities that the development of novel and better sensors for magnesium still faces...
  32. ncbi Magnesium deficiency inhibits primary tumor growth but favors metastasis in mice
    Anna Nasulewicz
    Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 R Weigl Street, 53 114 Wrocław, Poland
    Biochim Biophys Acta 1739:26-32. 2004
    ..In conclusion, our results demonstrate a direct role of magnesium in tumor growth and also point at deleterious effect of low magnesium status on tumor metastasis...
  33. ncbi Evaluation of magnesium fluxes in rat erythrocytes using a stable isotope of magnesium
    Aurelie Chanson
    CRNH dAuvergne, Unite Maladies Metaboliques et Micronutriments, INRA, Clermont Ferrand, France
    Front Biosci 10:1720-6. 2005
    ....
  34. ncbi 8-hydroxyquinoline derivatives as fluorescent sensors for magnesium in living cells
    Giovanna Farruggia
    Dipartimento di Biochimica G Moruzzi, Via Irnerio 48, Universita degli Studi di Bologna, 40126 Bologna, Italy
    J Am Chem Soc 128:344-50. 2006
    ..These findings suggest that DCHQ derivatives may serve as new tools for the study of Mg(2+) regulation, allowing sensitive and straightforward detection of both static and dynamic signals...
  35. ncbi Insights into the mechanisms involved in magnesium-dependent inhibition of primary tumor growth
    Jeanette A M Maier
    Dipartimento di Scienze Precliniche LITA Vialba, Universita di Milano, Milano, Italy
    Nutr Cancer 59:192-8. 2007
    ..Our results suggest that Mg has multiple and complex roles in tumor development...